Regenerative Medicine
Establishing new urologic tissue reconstruction models and developing treatment strategies for inflammation-based urologic conditions.
Earl Cheng LabConducting bladder tissue engineering research
Conducting bladder tissue engineering research
Research Description
Dr. Cheng is a national expert in complex reconstructive urology and co-directs a basic science laboratory with Arun Sharma, PhD, that focuses on tissue engineering techniques for the urinary tract, with emphasis on bladder regeneration. He also has a special interest in the medical and surgical management of individuals with sex development conditions that can result in ambiguous genitalia.
Publications
- Faasse MA, Farhat WA, Rosoklija I, Shannon R, Odeh RI, Yoshiba GM, Zu'bi F, Balmert LC, Liu DB, Alyami FA, Beaumont JL, Erickson DL, Gong EM, Johnson EK, Judd S, Kaplan WE, Kaushal G, Koyle MA, Lindgren BW, Maizels M, Marcus CR, McCarter KL, Meyer T, Qureshi T, Saunders M, Thompson T, Yerkes EB, Cheng EY. Randomized trial of prophylactic antibiotics vs. placebo after midshaft-to-distal hypospadias repair: the PROPHY Study. J Pediatr Urol. 2022 Apr;18(2):171-177.
- Tanaka ST, Yerkes EB, Routh JC, Tu DD, Austin JC, Wiener JS, Vasquez E, Joseph DB, Ahn JJ, Wallis MC, Williams T, Rose C, Baum MA, Cheng EY. Urodynamic characteristics of neurogenic bladder in newborns with myelomeningocele and refinement of the definition of bladder hostility: Findings from the UMPIRE multi-center study. J Pediatr Urol. 2021 Oct;17(5):726-732.
- Chan YY, D'Oro A, Yerkes EB, Rosoklija I, Balmert LC, Lindgren BW, Gong EM, Liu DB, Johnson EK, Chu DI, Cheng EY. Challenging proximal hypospadias repairs: An evolution of technique for two stage repairs.J Pediatr Urol. 2021 Apr; 17(2): 225.e1-225.e8.
- Johnson EK, Jacobson DL, Finlayson C, Yerkes EB, Goetsch AL, Leeth EA, Cheng EY. Proximal Hypospadias-Isolated Genital Condition or Marker of More? The Journal of urology. August 2020.
Contact
For contact information, view Dr. Cheng's faculty profile. Edward Gong LabStudying the mechanisms behind pathologic bladder degeneration
Studying the mechanisms behind pathologic bladder degeneration
Research Description
Bladder dysfunction from obstruction or denervation is the cause of kidney failure in many pediatric patients. Dr. Gong leads research to determine mechanisms behind pathologic bladder degeneration. His goal is to develop therapeutic agents that can prevent loss of bladder function and promote regeneration of healthy bladder tissue in children affected by posterior urethral valves or neurogenic bladder.
Publications
- Rague JT, Shannon R, Rosoklija I, Lindgren BW, Gong EM. Robot-assisted laparoscopic urologic surgery in infants weighing ≤10 kg: A weight stratified analysis. J Pediatr Urol. 2021 Dec;17(6):857.e1-857.e7.
- Tassone NM, Li B, Patel MS, Devine MY, Firmiss PR, Gould AD, Kochan KS, Stubbee RA, Bowen DK, Dettman RW, Gong EM. Stem cell antigen/Ly6a protects against bladder fibrosis in mice. American Journal of Physiology - Renal Physiology. December 2019.
- Morrison CD, Shannon R, Rosoklija I, Nettey OS, Superina R, Cheng EY, Gong EM. Ureteral Complications of Pediatric Renal Transplantation. Journal of Urology. April 2019.
- Li B, Liu DB, Gong EM. Robot-assisted laparoscopic transplant-to-native ureteroureterostomy of an intraperitoneal renal allograft. Journal of Pediatric Urology. August 2018.
Contact
Find contact information on Dr. Gong's faculty profile. Arun Sharma LabUrologic regenerative medicine/tissue engineering, nano- and bio-inspired materials
Urologic regenerative medicine/tissue engineering, nano- and bio-inspired materials
Research Description
The primary research focus of the lab is urologic regenerative medicine, specifically tissue engineering utilizing nanomolecules and novel synthetic biomaterials in bladder regeneration models. We study the regenerative applications of combining novel elastomeric scaffolds with an array of stem and progenitor cell populations in order to recapitulate the native bladder environment.
Publications
- Sharma TT, Rabizadeh RR, Prabhakar VS, Bury MI, Sharma AK. Evolving Experimental Platforms to Evaluate Ulcerative Colitis. Adv Biol (Weinh). 2022 Jul 22:e2200018.
- Chan YY, Bury MI, Fuller NJ, Nolan BG, Gerbie EY, Hofer MD, Sharma AK. Effects of Anti-Inflammatory Nanofibers on Urethral Healing. Macromol Biosci. 2021 May; 21(5): e2000410-.
- Bury MI, Fuller NJ, Sturm RM, Rabizadeh RR, Nolan BG, Barac M, Edassery SS, Chan YY, Sharma AK. The effects of bone marrow stem and progenitor cell seeding on urinary bladder tissue regeneration. Sci Rep. 2021 Jan; 11(1): 2322-.
- Chan YY, Bury MI, Yura EM, Hofer MD, Cheng EY, Sharma AK. The current state of tissue engineering in the management of hypospadias. Nature Reviews Urology. March 2020.
- Sharma A. Stem cells to help the heart. Science. March 2020.
- Iannaccone PM, Galat V, Bury MI, Ma YC, Sharma AK. The utility of stem cells in pediatric urinary bladder regeneration. Pediatric Research, January 2018.