Clinical Trials
Feinberg Clinical Trials
Scientists at the medical school are conducting hundreds of clinical trials daily. Learn more about all our work via the Feinberg Office of Research Clinical Trials page, and find specific trials by searching for a disease or condition below.
For more information about the research or participation, please call our office at 312-908-8145.
Trials |
---|
Microbiomes of Pelvic Pain Interstitial cystitis/painful bladder syndrome (IC) is characterized by chronic pelvic pain and voiding
dysfunction. IC remains an enigma within urology, with no known etiology or widely effective
therapies. However, some IC patients suffer bowel co-morbidities, and it … Interstitial cystitis/painful bladder syndrome (IC) is characterized by chronic pelvic pain and voiding
dysfunction. IC remains an enigma within urology, with no known etiology or widely effective
therapies. However, some IC patients suffer bowel co-morbidities, and it is well established that the
GI tract can influence bladder function and sensation via pelvic organ crosstalk.
Like other body sites, the gut harbors a rich microflora. Studies characterizing microbial
diversity and relative abundance at a particular body site, the “microbiome,” reveal that microbiomes
play critical roles in normal cellular and organ function, and thus this importance is emphasized with
the Human Microbiome Project (HMP), an NIH Common Fund initiative. Microbiomes are also
dynamic and subject to skewing, and these changes are increasingly associated with diseases
including Crohn’s disease, ulcerative colitis, and obesity. Antibiotic therapies alter microbiomes, often
causing temporary dysfunction and sometimes
resulting in diseases such as colitis. Since IC patients
often have a history of urinary tract infection (UTI),
they typically receive multiple courses of antibiotics.
This therapeutic history of IC patients may have
adverse consequences for two reasons. First, potential
skewing of the gut microbiome may alter normal
sensory and functional homeostatic mechanisms, contributing to pain and voiding dysfunction.
Second, an altered gut microbiome may foster uropathogen reservoir expansion, and our preliminary
data demonstrate urinary E. coli isolates can induce chronic pelvic pain persisting long after microbial
clearance. Together these lines of reasoning raise the provocative possibility that microbiomes
contribute to IC directly by supplying uropathogens or indirectly through organ crosstalk
dysfunction. Therefore, is an altered gastrointestinal and/or reproductive tract microbiome
associated with IC?
Our team marries core NIH and NIDDK missions, digestive diseases and kidney/urologic, to
address this novel question with synergistic expertise in clinical diagnosis of IC, quantifying GI and
reproductive tract microbiomes, and mechanisms of microbe-induced pelvic pain.
STU00055668 |
The Genetics of Prostate Cancer in Active Surveillance Our study uses saliva samples to detect whether or not active surveillance is the best option for the subject, based on their their genetic makeup and susceptibility to aggressive prostate cancer. 1. Patients diagnosed with prostate cancer 2. Patients with Gleason ≤ 3+3 prostate cancer 3. Patients with fewer than 3 cores involved with cancer. If a patient has 3 or more cores involved with cancer but still meets all pathologic criteria and after discussing risks and benefits does not want definitive treatment, he may still be eligible for active surveillance. 4. Patients with no more than 50% of any 1 core involved with prostate cancer. If a patient has more than 50% of any 1 core involved with prostate cancer but still meets all pathologic criteria and after discussing risks and benefits does not want definitive treatment, he may still be eligible for active surveillance. 5. Patients age > 18. Patients are typically offered AS if they are ≥ 60 years of age. However, if a man meets pathologic criteria and is < 60, he can be entered in AS if, after discussing risks and benefits, does not want definitive treatment. 6. Most patients will have PSA value ≤ 10 ng/ml. However, since PSA is prostate specific and not prostate cancer specific, many patients with elevated PSA levels > 10 ng/ml will not have prostate cancer, and PSA is elevated due to conditions such as BPH or inflammation. If a patient has a PSA value > 10 ng/ml, but still meets all pathologic criteria, he may still be eligible for active surveillance
STU00059221 |
Prostatic Artery Embolization (PAE) for Treatment of Signs and Symptoms of Benign Prostatic Hyperplasia (BPH)
This is an open-labeled, non-randomized feasibility study to evaluate the safety of prostate
artery embolization (PAE) for the treatment of lower urinary tract symptoms a…
This is an open-labeled, non-randomized feasibility study to evaluate the safety of prostate
artery embolization (PAE) for the treatment of lower urinary tract symptoms attributed to
benign prostatic hyperplasia (BPH).
NCT02026908 STU00081296 |
MAST CELLS IN MALE CHRONIC PELVIC PAIN AND LOWER URINARY TRACT DYSFUNCTION The purpose of this study is to figure out if drug treatments using cromolyn sodium and cetirizine hydrochloride lessen painful symptoms in patients suffering from chronic pelvic pain syndrome (CPPS). Men diagnosed with Category IIIB Chronic Pelvic Pain Syndrome reporting pain or discomfort in any of the 8 domains of the NIH Chronic Prostatitis Symptom Index (NIH-CPSI). Symptoms must have been present for the majority of the time during any 3 months in the previous 6 months.
NCT03167216 STU00202831 |
NU 15U06: A Phase 1 Dose-Escalation Study of Intravesical Pembrolizumab and Bacillus Calmette-Guerin (BCG) in Subjects with High Risk and BCG-Refractory Non-Muscle-Invasive Bladder Cancer Purpose
The purpose of this study is to evaluate the efficacy (the effect of drug on tumor) and the tolerabili… Purpose
The purpose of this study is to evaluate the efficacy (the effect of drug on tumor) and the tolerability (the effect of drug on the body) of Pembrolizumab, when given as a single agent in patients with bladder tumors. Another purpose of the study is to see what tumor characteristics are associated with increased efficacy of the Pembrolizumab.
Overview
Pembrolizumab (MK-3475) is an antibody (a human protein that sticks to a part of the tumor and/or immune cells) designed to allow the body‰Ûªs immune system to work against tumor cells. Pembrolizumab is FDA approved for the treatment of advanced melanoma (a type of skin cancer) and some types of lung cancer. It is not yet approved by the USFDA for bladder cancer, hence it is considered an investigational agent for this disease.
Description of Treatment
All study participants will take the same study drug, Pembrolizumab. Pembrolizumab will be given intravesically through urethra. With intravesical therapy, doctor administers the drug directly into the bladder (through a catheter), rather than giving it by mouth or injecting it into a vein. During the first six weeks of therapy, one will also receive treatment with BCG as a standard of care. We expect that one will receive treatment for up to 1 year or until your disease gets worse (whichever occurs first). After completing treatment, the study team will continue to watch you for side effects for at least 30 days. The study team will also continue to check periodically to see how you are doing until your disease returns. Some of the eligibility criteria include: - Participants must have a recurrent, high or low risk non-muscle-invasive bladder carcinoma. - Participants must (be BCG refractory) have received at least one 6-week course of BCG induction plus 1 maintenance dose, OR 2 full 6-week courses of induction BCG treatment. - Participants must be 18 or older. Note: This is only a partial list of eligibility criteria. Please contact the Lurie Cancer Center for complete screening information if you are interested in this clinical trial.
NCT02808143 STU00202754 |
The Molecular Markers of Bladder Cancer Genetic research may discover genes, find out how genes function, or help researchers learn how to use what we know about genes to treat or prevent and treat disease. The purpose is to study whether the results of genetic testing can predict if bladder cancer i… Genetic research may discover genes, find out how genes function, or help researchers learn how to use what we know about genes to treat or prevent and treat disease. The purpose is to study whether the results of genetic testing can predict if bladder cancer is going to recur, progress (get worse), or respond to chemotherapy. Male or female patients ages 40-89 with high-grade T1 bladder cancer or patients with muscle invasive (>T2) bladder cancer undergoing neoadjuvant chemotherapy and radical cystectomy. STU00204352 For more information on this study please contact us: 312 695 8146 |
(xIRB NCI CIRB) SWOG 1602: A Phase III Randomized Trial to Evaluate the Influence of BCG Strain Differences and T Cell Priming with Intradermal BCG Before Intravesical Therapy for BCG-Naïve High-Grade Non-Muscle Invasive Bladder Cancer The purpose of this study is to test two things:• Compare any … The purpose of this study is to test two things:• Compare any good and bad effects of using the Tokyo-172 version of BCG with thecurrently used BCG LIVE (TICE® BCG) version of BCG on people with bladdercancer receiving BCG in the bladder. The study will be considered successful ifapproximately the same number of patients who receive the different treatments arefree from high grade recurrence of their bladder cancer after one year of treatment.• Using the Tokyo-172 version of BCG, compare any good and bad effects of adding aBCG vaccination (given under the skin) in addition to placing BCG in only thebladder. The study will be considered successful if the vaccination results in an 8%improvement in the number of patients who are free from high grade recurrence oftheir bladder cancer after one year of treatment. Some of the eligibility criteria include: - Participants must have high grade bladder cancer thathas not entered the muscle - Participants must be 18 or older - Note: This is only a partial list of eligibility criteria. Please contact the Lurie Cancer Center for complete screening information if you are interested in this clinical trial.
NCT03091660 STU00205010 |
Isolation of peripheral blood mononuclear cells to develop novel therapeutics for cancer and autoimmune diseases The purpose of this study is to collect blood samples to help find new ways to treat diseases.
Our lab develops small particles that have the potential to be useful for the delivery of t… The purpose of this study is to collect blood samples to help find new ways to treat diseases.
Our lab develops small particles that have the potential to be useful for the delivery of therapeutic agents like anticancer drugs to cells or to remove biotoxins from the human body. We would like to test in the laboratory if these particles have any harmful effects on human blood cells. You will not come in contact with these particles, and all experiments will be performed on the blood sample only.
You will be asked to provide a blood sample. About 10mls or approximately 2 tablespoons will be drawn.
|