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Clinical Trials

Trials

PACTG 1026s: PHARMACOKINETIC PROPERTIES OF ANTIRETROVIRAL AND RELATED DRUGS DURING PREGNANCY AND POSTPARTUM

The purpose of this study is to evaluate the pharmacokinetics (PKs) of antiretroviral (ARV) and tuberculosis (TB) medications in pregnant women and their infants. (Pharmacokinetics are the various interactions between a drug and the body.) This study will also evaluate the PKs of certain ARVs in postpartum women before and after starting hormonal contraceptives. The PKs of these drugs will be evaluated by measuring the amount of medicine present in blood and/or vaginal secretions.
This study is closed to accrual and is no longer recruiting subjects.
Jao, JenniferJao, Jennifer
NCT00042289 STU00030724
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NCI 01X1: Breast Cancer Program: Tissue and Specimen Collection Facility

The purpose of this research study is to help advance the scientific understanding of breast cancer. A portion of breast or skin tissue and a sample of blood, along with clinical information, will be collected and stored in a database for research purposes only. Only tissue or fluid in excess …

The purpose of this research study is to help advance the scientific understanding of breast cancer. A portion of breast or skin tissue and a sample of blood, along with clinical information, will be collected and stored in a database for research purposes only.

Only tissue or fluid in excess of that required for clinical diagnosis and/or staging will be collected. Specific clinical data will include: treatment for cancer (surgical procedures, chemo or hormone therapy, radiation), cancer outcome (recurrence, metastases, death due to disease, and death without disease, alive, alive with disease).

You may be eligible for this research study if you are a woman with breast cancer undergoing biopsy or surgical procedures for the diagnosis, treatment, or prevention of your cancer. 
Wei, Jian-JunWei, Jian-Jun
  • Map it 201 E. Huron St.
    Chicago, IL
NCT00898131 STU00023488
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The effect of magnesium on maternal mood, cognitive function, and birth experience

Magnesium is sometimes used to prevent seizures in the setting of hypertensive disorders of pregnancy. The primary aim of this study is to determine if women who receive magnesium are less likely to experience postpartum depression. Other aims include examining the relationship between receiving magnesium and cognitive function and birth experience.
Miller, Emily StinnettMiller, Emily Stinnett
NCT02454322 STU00200388
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Minimally Invasive Burch Colposuspension to Reduce Occult Stress Incontinence

We are conducting this research study because we are seeking a better treatment regimen for patients that have pelvic organ prolapse (POP). Surgical correction of POP can result in development of stress urinary incontinence (SUI) - leakage of urine associated with cough, laugh or sneeze even in patients who have never …
We are conducting this research study because we are seeking a better treatment regimen for patients that have pelvic organ prolapse (POP). Surgical correction of POP can result in development of stress urinary incontinence (SUI) - leakage of urine associated with cough, laugh or sneeze even in patients who have never had these symptoms before. We therefore want to investigate if addition of minimally invasive Burch colposuspension at the time of sacrocolpopexy will help prevent SUI after surgery in women who do not have pre-existing symptoms of SUI. If our hypothesis that minimally invasive Burch colposuspension at the time of minimally invasive sacrocolpopexy will lower rates of SUI after surgery is correct, this could greatly improve upon our current surgical treatment of women with POP. 

You may be eligible for this study if you are a woman over the age of 18 who is planning to have a laparoscopic or robotic sacrocolpopexy, with or without hysterectomy. Participants may be English or Spanish speaking and reading. This study is for women who are stress continent, who do not leak urine with coughing, sneezing, or laughing. To participate in this study you must have completed childbearing.

Exclusion Criteria:

  • Pregnant women or patients desiring future pregnancy
  • Patients undergoing uterine sparing surgery
  • Individuals under age 18
  • Prior procedure for stress urinary incontinence
  • Prior retropubic surgery

Collins, Sarah AbbieCollins, Sarah Abbie
  • Map it 676 N St. Clair Arkes Pavillion Suite 950
    Chicago, IL
NCT03841513 STU00208016
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Randomized trial of Retropubic versus Single-incision Mid-Urethral Sling (Altis™) for Concomitant Management of Stress urinary incontinence during Native Tissue Vaginal Repair

This study is for women who have stress urinary incontinence when their vaginal bulge is returned to its normal position and who have opted for surgical management with a sling that will help support the urethra or the tube that carries urine from the bladder to the outside of the …
This study is for women who have stress urinary incontinence when their vaginal bulge is returned to its normal position and who have opted for surgical management with a sling that will help support the urethra or the tube that carries urine from the bladder to the outside of the body. The purpose of this study is to compare two different types of FDA approved slings used for surgery. Participants will be asked to complete study questionnaires and attend 6 regular care visits. 
You may be eligible for this study if:

  • You are at least 21 years of age
  • You are a woman being considered for a native vaginal repair in any vaginal compartment or colpocleisis
  • You have pelvic organ prolapse stage 2-4 and have vaginal bulge symptoms

Kenton, Kimberly SueKenton, Kimberly Sue
  • Map it 676 N St. Clair Arkes Pavillion Suite 950
    Chicago, IL
NCT03520114 STU00208116
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