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Clinical Trials

Trials
PACTG 1026s: PHARMACOKINETIC PROPERTIES OF ANTIRETROVIRAL AND RELATED DRUGS DURING PREGNANCY AND POSTPARTUM
The purpose of this study is to evaluate the pharmacokinetics (PKs) of antiretroviral (ARV) and tuberculosis (TB) medications in pregnant women and their infants. (Pharmacokineti…
The purpose of this study is to evaluate the pharmacokinetics (PKs) of antiretroviral (ARV) and tuberculosis (TB) medications in pregnant women and their infants. (Pharmacokinetics are the various interactions between a drug and the body.) This study will also evaluate the PKs of certain ARVs in postpartum women before and after starting hormonal contraceptives. The PKs of these drugs will be evaluated by measuring the amount of medicine present in blood and/or vaginal secretions.
This study is closed to accrual and is no longer recruiting subjects.
Jao, JenniferJao, Jennifer
NCT00042289 STU00030724
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NCI 01X1: Breast Cancer Program: Tissue and Specimen Collection Facility

The purpose of this research study is to help advance the scientific understanding of breast cancer. A portion of breast or skin tissue and a sample of blood, along with clinical information, will be collected and stored in a…

The purpose of this research study is to help advance the scientific understanding of breast cancer. A portion of breast or skin tissue and a sample of blood, along with clinical information, will be collected and stored in a database for research purposes only.

Only tissue or fluid in excess of that required for clinical diagnosis and/or staging will be collected. Specific clinical data will include: treatment for cancer (surgical procedures, chemo or hormone therapy, radiation), cancer outcome (recurrence, metastases, death due to disease, and death without disease, alive, alive with disease).

You may be eligible for this research study if you are a woman with breast cancer undergoing biopsy or surgical procedures for the diagnosis, treatment, or prevention of your cancer. 
Wei, Jian-JunWei, Jian-Jun
  • Map it 201 E. Huron St.
    Chicago, IL
STU00023488
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Nulliparous Pregnancy Outcomes Study: Monitoring Mothers to be
Forty percent of pregnant women in the United States are women who have never given birth. As a group, they sometimes have complications with their pregnancy, but there is no information from a previous pregnancy to identify who might ha…
Forty percent of pregnant women in the United States are women who have never given birth. As a group, they sometimes have complications with their pregnancy, but there is no information from a previous pregnancy to identify who might have a problem. Very little research has been done with this group. The Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be (nuMoM2b) is collecting data from a diverse population of about 10,000 women who are having their first baby and are carrying only one baby. The women are enrolled early in pregnancy and undergo research assessments four times during their pregnancies. Data are collected through interviews, self-completed data forms, clinical measurements, ultrasound, and collection and storage of blood samples, urine samples, and fluid from the vagina and cervix. Some information comes from medical records. A subset of women may be asked to participate in substudies collecting information on sleep breathing, sleep patterns and quality, or other areas possibly related to birth outcomes. The goal of the research is to find ways to identify women in this group who might develop a problem with their pregnancy and use this information to improve the health of pregnant women and their babies in the future. The study is focusing on pregnancy problems like high blood pressure, babies that are born much too early and very small babies.
Recruitment closed.
Grobman, William AGrobman, William A
  • Map it 633 N. St. Clair St
    Chicago, IL
NCT01322529 STU00030993
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B-WELL-Mom (Breathe-Wellbeing, Environment, Lifestyle, and Lung Function)
This NIH funded research study is to better understand how the lungs function during pregnancy and how the immune system responds to pregnancy. This study will help us to better understand why some women with asthma experience…
This NIH funded research study is to better understand how the lungs function during pregnancy and how the immune system responds to pregnancy. This study will help us to better understand why some women with asthma experience worsening of their symptoms while others improve. Because pregnancy affects lung function and immune response of all women, we are looking for both women with and without asthma to participate. The study consists of 4 clinic visits (1st, 2nd, and 3rd trimesters of pregnancy and 4 months postpartum), and an at-home diary.
-Pregnant women at least 18 years old.
-Less than 15 weeks pregnant with a single baby.
-Women with and without asthma are eligible to participate. -No diagnosis of Multiple Sclerosis, Lupus, Rheumatoid Arthritis, HIV, or Mixed Connective Tissue Disease.
Grobman, William AGrobman, William A
STU00093038
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Pregnancy as a Window to Future Cardiovascular Health: Adverse Pregnancy Outcomes as Predictors of Increased Risk Factors for Cardiovascular Disease
This study is looking at the relationship between experiences during pregnancy and cardiovascular health 2 to 7 years postpartum. The investigators are …
This study is looking at the relationship between experiences during pregnancy and cardiovascular health 2 to 7 years postpartum. The investigators are recruiting women from the approximately 10,000 women who were enrolled and followed over the course of their first pregnancy in the nuMOM2b Study.
By invitation only. Women who previously participated in the nuMOM2b Study and who are 18+ years old are invited to participate in the nuMOM2b Heart Health Study. These women also consented to be contacted for future research studies and did not previously withdraw from the nuMoM2b cohort.
Grobman, William AGrobman, William A
  • Map it 633 N. St. Clair St
    Chicago, IL
NCT02231398 STU00098233
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The effect of magnesium on maternal mood, cognitive function, and birth experience
Magnesium is sometimes used to prevent seizures in the setting of hypertensive disorders of pregnancy. The primary aim of this study is to determine if women who receive magnesium are less …
Magnesium is sometimes used to prevent seizures in the setting of hypertensive disorders of pregnancy. The primary aim of this study is to determine if women who receive magnesium are less likely to experience postpartum depression. Other aims include examining the relationship between receiving magnesium and cognitive function and birth experience.
Miller, Emily StinnettMiller, Emily Stinnett
NCT02454322 STU00200388
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Optimizing Medication Management for Mothers with Depression (OPTI-MOM)

The purpose of this study is to explore the way the antidepressant concentration (amount of medication) in the

blood changes due to the physiological changes in the body (i.e., increased metabolism, hormones, and body

The purpose of this study is to explore the way the antidepressant concentration (amount of medication) in the

blood changes due to the physiological changes in the body (i.e., increased metabolism, hormones, and body

fluid) during pregnancy and postpartum. Taking the same medication dose when you are pregnant may result in

an amount of drug in your blood that is different than when you are not pregnant. We will also study the impact

of genetic factors on the amount of drug in your blood. Drug metabolism (how medications are broken down,

absorbed, and removed from the body) differs among people because of their unique genetic make-up, which can

cause medications to be metabolized faster or slower. This means that when two people with different genetic

backgrounds take the same dose, the concentration of the medicine in their blood can vary dramatically.

Changes in antidepressant concentrations are important to monitor because a decrease in the blood level of the

drug may result in the antidepressant becoming ineffective and an increase in mood symptoms or recurrence of

depression may occur. An increase in antidepressant concentration may lead to side effects. We aim to better

understand the course of these changes across pregnancy and postpartum and determine how n woman’s genetic

makeup affects these changes. Our overall goal is to develop guidelines to optimize antidepressant treatment of

pregnant women.

Pregnant women ages 18-45 years old less than 18 weeks pregnant with a singleton pregnancy taking sertraline (Zoloft), fluoxetine (Prozac), escitalopram (Lexapro), or citalopram (Celexa) and plan to continue this medication throughout pregnancy and through the first 4 months postpartum. 
Wisner, Katherine LeahWisner, Katherine Leah
  • Map it 676 N. St. Clair St.
    Chicago, IL
STU00201386
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Minimally Invasive Burch Colposuspension to Reduce Occult Stress Incontinence
We are conducting this research study because we are seeking a better treatment regimen for patients that have pelvic organ prolapse (POP). Surgical correction of POP can result in development of stress urinary incontinence…
We are conducting this research study because we are seeking a better treatment regimen for patients that have pelvic organ prolapse (POP). Surgical correction of POP can result in development of stress urinary incontinence (SUI) - leakage of urine associated with cough, laugh or sneeze even in patients who have never had these symptoms before. We therefore want to investigate if addition of minimally invasive Burch colposuspension at the time of sacrocolpopexy will help prevent SUI after surgery in women who do not have pre-existing symptoms of SUI. If our hypothesis that minimally invasive Burch colposuspension at the time of minimally invasive sacrocolpopexy will lower rates of SUI after surgery is correct, this could greatly improve upon our current surgical treatment of women with POP. 

You may be eligible for this study if you are a woman over the age of 18 who is planning to have a laparoscopic or robotic sacrocolpopexy, with or without hysterectomy. Participants may be English or Spanish speaking and reading. This study is for women who are stress continent, who do not leak urine with coughing, sneezing, or laughing. To participate in this study you must have completed childbearing.

Exclusion Criteria:

  • Pregnant women or patients desiring future pregnancy
  • Patients undergoing uterine sparing surgery
  • Individuals under age 18
  • Prior procedure for stress urinary incontinence
  • Prior retropubic surgery

Collins, Sarah AbbieCollins, Sarah Abbie
  • Map it 676 N St. Clair Arkes Pavillion Suite 950
    Chicago, IL
NCT03841513 STU00208016
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Randomized trial of Retropubic versus Single-incision Mid-Urethral Sling (Altis™) for Concomitant Management of Stress urinary incontinence during Native Tissue Vaginal Repair
This study is for women who have stress urinary incontinence when their vaginal bulge is returned to its normal position an…
This study is for women who have stress urinary incontinence when their vaginal bulge is returned to its normal position and who have opted for surgical management with a sling that will help support the urethra or the tube that carries urine from the bladder to the outside of the body. The purpose of this study is to compare two different types of FDA approved slings used for surgery. Participants will be asked to complete study questionnaires and attend 6 regular care visits. 
You may be eligible for this study if:

  • You are at least 21 years of age
  • You are a woman being considered for a native vaginal repair in any vaginal compartment or colpocleisis
  • You have pelvic organ prolapse stage 2-4 and have vaginal bulge symptoms

Kenton, Kimberly SueKenton, Kimberly Sue
  • Map it 676 N St. Clair Arkes Pavillion Suite 950
    Chicago, IL
NCT03520114 STU00208116
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XIRB-Systems Biology of Early Atopy (SUNBEAM)

Food allergy affects approximately 5-10% of young children, with highest incidence in the first year of life. Atopic dermatitis (eczema) is a major risk factor for food allergy and other allergic diseases, and it has a significant impact on child healt…

Food allergy affects approximately 5-10% of young children, with highest incidence in the first year of life. Atopic dermatitis (eczema) is a major risk factor for food allergy and other allergic diseases, and it has a significant impact on child health. We hope to learn more about factors that put very young children at higher risk for food allergies and atopic dermatitis (eczema). This study with Dr. Amy Paller (Department of Dermatology) and Dr. William Grobman (Department of Obstetrics and Gynecology) will focus on risk factors that may be present before, during, and after birth and through the age of 3 years. Identifying early life markers of those at risk could help with implementation of current prevention methods and discovery of new prevention methods.

This study will enroll pregnant women at any stage who are at least 18 years of age and agree to enroll their child at birth.

Paller, AmyPaller, Amy
  • Map it 675 N. St. Clair St.
    Chicago, IL
  • Map it 676 N. St. Clair St.
    Chicago, IL
  • Map it 675 N. Saint Clair St. Fourteenth Floor, Suite 200
    Chicago, IL
NCT04798079 STU00213999
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