Education Publications Contact Information

Dr. Klumpp was appointed to direct Dr. Anthony Schaeffer's laboratory in 1998. Along with his collaborative team of research technologists and physicians, he investigates basic bladder biology and pathogenesis of the urinary tract focusing on host susceptibility to urinary tract infections (UTI).

For more detailed information regarding projects and research currently in progress in Dr. Klumpp's laboratory, visit http://www.klumpplab.org

Education

Undergraduate: University of Iowa, Iowa City, IA
Graduate: PhD, Biochemistry, Molecular and Cell Biology, Northwestern University, Evanston, IL
Post-graduate: Feinberg School of Medicine, Northwestern University, Chicago, IL

Selected Publications
The following publications are selected from a complete CV. For more information on Dr. Klumpp's scholarly productivity, please contact his office.

Journal Articles

1. Chung T, Klumpp DJ, LaPorte DC. Glyoxylate bypass operon of Escherichia coli: cloning and determination of the functional map. J Bacteriol. 170(1):386-92. 1988.
2. Klumpp DJ, Plank DW, Bowdin LJ, Stueland CS, Chung T, LaPorte DC. Nucleotide sequence of aceK, the gene encoding isocitrate dehydrogenase kinase/phosphatase. J Bacteriol. 170(6):2763-9. 1988.
3. Sunnarborg A, Klumpp DJ, Chung T, LaPorte DC. Regulation of the glyoxylate bypass operon: cloning and characterization of iclR. J Bacteriol. 172(5):2642-9. 1990.
4. Klumpp DJ, Farber DB, Bowes C, Song EJ, Pinto LH. The potassium channel MBK1 (Kv1.1) is expressed in the mouse retina. Cell Mol Neurobiol. 11(6):611-22. 1991.
5. Klumpp DJ, Song EJ, Ito S, Sheng MH, Jan LY, Pinto LH. The Shaker-like potassium channels of the mouse rod bipolar cell and their contributions to the membrane current. J Neurosci. 15(7 Pt 1):5004-13. 1995.
6. Klumpp DJ, Song EJ, Pinto LH. Identification and localization of K+ channels in the mouse retina. Vis Neurosci. 12(6):1177-90. 1995.
7. Kyo S, Klumpp DJ, Inoue M, Kanaya T, Laimins LA. Expression of AP1 during cellular differentiation determines HPV E6/E7 expression in stratified epithelial cells. J Gen Virol. 78(Pt 2):401-11. 1997.
8. Klumpp DJ, Stubenrauch F, Laimins LA. Differential effects of the splice acceptor at nucleotide 3295 of human papillomavirus type 31 on stable and transient viral replication. J Virol. 71(11):8186-94. 1997.
9. Pinto LH, Klumpp DJ. Localization of potassium channels in the retina. Prog Retin Eye Res. 17(2):207-30. 1998.
10. Klumpp DJ, Laimins LA. Differentiation-induced changes in promoter usage for transcripts encoding the human papillomavirus type 31 replication protein E1. Virology. 257(1):239-46. 1999.
11. Tamatani T, Hattori K, Nakashiro K, Hayashi Y, Wu S, Klumpp DJ, Reddy JK, Oyasu R. Neoplastic conversion of human urothelial cells in vitro by overexpression of H2O2-generating peroxisomal fatty acyl CoA oxidase. Int J Oncol. 15(4):743-9. 1999.
12. Schoor RA, Anderson BE, Klumpp DJ, Schaeffer AJ. Secretory IgA differentially promotes adherence of type 1-piliated Escherichia coli to immortalized vaginal epithelial cell lines. Urology. 57(3):556-61. 2001.
13. Klumpp DJ, Weiser AC, Sengupta S, Forrestal SG, Batler RA, Schaeffer AJ. Uropathogenic Escherichia coli potentiate type 1 pili-induced apoptosis by suppressing NF-kappaB activation. Infect Immun. 69(11):6689-95. 2001.
14. Batler RA, Sengupta S, Forrestal SG, Schaeffer AJ, Klumpp DJ. Mast cell activation triggers a urothelial inflammatory response mediated by tumor necrosis factor-alpha. J Urol. 168(2):819-25. 2002.
15. Klumpp DJ, Forrestal SG, Karr JE, Mudge CS, Anderson BE, Schaeffer AJ. Epithelial differentiation promotes the adherence of type 1-piliated Escherichia coli to vaginal epithelial cells. J Infect Dis. 186(11):1631-8. 2002.
16. Garcia AF, Chang TH, Benchimol M, Klumpp DJ, Lehker MW, Alderete JF. Iron and contact with host cells induce expression of adhesins on surface of Trichomonas vaginalis.  Mol Microbiol. 47(5):1207-24. 2003.
17. Fehrmann F, Klumpp DJ, Laimins LA. Human papillomavirus type 31 E5 protein supports cell cycle progression and activates late viral functions upon epithelial differentiation. J Virol. 77(5):2819-31. 2003.
18. Mundodi V, Kucknoor AS, Klumpp DJ, Chang TH, Alderete JF. Silencing the ap65 gene reduces adherence to vaginal epithelial cells by Trichomonas vaginalis. Mol Microbiol. 53(4):1099-108. 2004.
19. Klumpp DJ, Forrestal SG Johnson J, Schaeffer AJ. Suppression of the urothelial inflammatory response by commensal and extraintestinal pathogenic Escherichia coli. J Infect Dis. Submitted.
20. Mudge CS, Klumpp DJ.  Induction of the urothelial differentiation program is independent of stromal cues. In preparation.
21. Klumpp DJ, Sengupta S, Rycyk MT, Schaeffer AJ. Type 1 pili of uropathogenic Escherichia coli induce urothelial apoptosis via both stress and death receptor pathways. In preparation.
22. Chen MC, Mudge CS, Blunt LW, Klumpp DJ. Bladder mast cell trafficking to stroma in neurogenic cystitis. In preparation.

Contact Information

Northwestern University, Feinberg School of Medicine
Department of Urology
303 East Chicago Avenue, Tarry 16-703
Chicago, IL 60611-3008
(312) 908-1996
Fax (312) 908-7275
d-klumpp@northwestern.edu

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Department of Urology
Northwestern University, Feinberg School of Medicine
303 East Chicago Avenue, Tarry 16-703
Chicago, IL 60611-3008
(312) 908-8145/ Fax (312) 908-7275 E-mail: m-grant@northwestern.edu