The Laimins Lab investigates how the transcriptional regulation activity of the TopBP1 scaffold protein influences the human papillomaviruses (HPV) life cycle.
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The Laimins Lab investigates how the transcriptional regulation activity of the TopBP1 scaffold protein influences the human papillomaviruses (HPV) life cycle.
The Hauser Lab investigates the population structure of the bacterial pathogen Pseudomonas aeruginosa.
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The Hauser Lab investigates the population structure of the bacterial pathogen Pseudomonas aeruginosa.
The Walsh Lab studies the central strategies used by poxviruses to control both host and viral protein synthesis.
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The Walsh Lab studies the central strategies used by poxviruses to control both host and viral protein synthesis.
The Cianciotto Lab studies the type II secretion system of Legionella pneumophila, the agent of Legionnaires’ disease.
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The Cianciotto Lab studies the type II secretion system of Legionella pneumophila, the agent of Legionnaires’ disease.
The Naghavi and Walsh Labs study how cytoskeletal regulation contributes to the early stages of viral infection, with a primary focus on retroviruses and herpesviruses.
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The Naghavi and Walsh Labs study how cytoskeletal regulation contributes to the early stages of viral infection, with a primary focus on retroviruses and herpesviruses.
The Longnecker Lab identifies ephrin receptor A4 (EphA4) as a new target cell entry receptor for Kaposi’s sarcoma-associated herpesviru (KSHV).
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The Longnecker Lab identifies ephrin receptor A4 (EphA4) as a new target cell entry receptor for Kaposi’s sarcoma-associated herpesviru (KSHV).

Seminars & Events

Dec
10
Department of Microbiology-Immunology: Joseph Sun, PhD
12:00 PM - 1:00 PM
Dec
13
Virology Journal Club - Work from invited speaker Dr. Jan Carette
12:00 PM - 1:00 PM
Dec
17
Department of Microbiology-Immunology: Jan Carette, PhD
12:00 PM - 1:00 PM
Jan
10
Department of Microbiology-Immunology: Edward M. Campbell, PhD
12:00 PM - 1:00 PM
Jan
10
Special dual M-I/Virology Club: Dr. Noam Stern-Ginossar
12:00 PM - 1:00 PM
Feb
13
Virology Club: Dr. Jia Chen
4:00 PM - 5:00 PM

News & Awards

11.25.2019Investigating How Hospital-Acquired Bacteria Cause Severe Infections
10.22.2019New treatment may reverse celiac disease
09.16.2019Vania Vidimar, PhD, to be honored at 2nd Annual Halo Awards
07.23.2019Podcast: Vibri-Oh-No! - Flesh Eating Vibrios with Karla Satchell
04.23.2019Study Explores How Pneumonia Strains Compete

Our Department

We investigate mechanisms of bacterial and viral pathogenesis as well as regulation of the immune system. Our faculty members teach graduate, undergraduate and medical students at Northwestern University and the Feinberg School of Medicine. Learn more about us.

Recent Publications

Structure of Galactarate Dehydratase, a New Fold in an Enolase Involved in Bacterial Fitness after Antibiotic Treatment.
Rosas-Lemus M, Minasov G, Shuvalova L, Wawrzak Z, Kiryukhina O, Mih N, Jaroszewski L, Palsson B, Godzik A, Satchell KJF.
Protein Sci. 2019 Dec 6. doi: 10.1002/pro.3796. [Epub ahead of print]
The Oncogenic Kaposi's Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor-Suppressive miR-15/16 miRNA Family.
Morrison K, Manzano M, Chung K, Schipma MJ, Bartom ET, Gottwein E.
Cell Rep. 2019 Dec 3;29(10):2961-2969.e6. doi: 10.1016/j.celrep.2019.11.005.
The Cyclic AMP Receptor Protein Regulates Quorum Sensing and Global Gene Expression in Yersinia pestis during Planktonic Growth and Growth in Biofilms.
Ritzert JT, Minasov G, Embry R, Schipma MJ, Satchell KJF.
MBio. 2019 Nov 19;10(6). pii: e02613-19. doi: 10.1128/mBio.02613-19.
N-terminal autoprocessing and acetylation of multifunctional-autoprocessing repeats-in-toxins (MARTX) Makes Caterpillars Floppy-like effector is stimulated by adenosine diphosphate (ADP)-Ribosylation Factor 1 in advance of Golgi fragmentation.
Herrera A, Muroski J, Sengupta R, Nguyen HH, Agarwal S, Ogorzalek Loo RR, Mattoo S, Loo JA, Satchell KJF.
Cell Microbiol. 2019 Oct 28:e13133. doi: 10.1111/cmi.13133. [Epub ahead of print]
Epithelial cell infection by Epstein-Barr virus.
Chen J, Longnecker R.
FEMS Microbiol Rev. 2019 Oct 4. pii: fuz023. doi: 10.1093/femsre/fuz023. [Epub ahead of print] No abstract available.
Long-term Persistence of an Extensively Drug Resistant Subclade of Globally Distributed Pseudomonas aeruginosa Clonal Complex 446 in an Academic Medical Center.
Pincus NB, Bachta KER, Ozer EA, Allen JP, Pura ON, Qi C, Rhodes NJ, Marty FM, Pandit A, Mekalanos JJ, Oliver A, …
Clin Infect Dis. 2019 Oct 4. pii: ciz973. doi: 10.1093/cid/ciz973. [Epub ahead of print]
PacBio Amplicon Sequencing Method To Measure Pilin Antigenic Variation Frequencies of Neisseria gonorrhoeae.
Ozer EA, Prister LL, Yin S, Ward BH, Ivanov S, Seifert HS.
mSphere. 2019 Oct 2;4(5). pii: e00562-19. doi: 10.1128/mSphere.00562-19.
The Herpes Simplex Virus 1 Deamidase Enhances Propagation but Is Dispensable for Retrograde Axonal Transport into the Nervous System.
Stults AM, Smith GA.
J Virol. 2019 Oct 29;93(22). pii: e01172-19. doi: 10.1128/JVI.01172-19. Print 2019 Nov 15.
Gammaherpesvirus entry and fusion: A tale how two human pathogenic viruses enter their host cells.
Möhl BS, Chen J, Longnecker R.
Adv Virus Res. 2019;104:313-343. doi: 10.1016/bs.aivir.2019.05.006. Epub 2019 Jul 17.
Type II Secretion Promotes Bacterial Growth within the Legionella-Containing Vacuole in Infected Amoebae.
White RC, Truchan HK, Zheng H, Tyson JY, Cianciotto NP.
Infect Immun. 2019 Oct 18;87(11). pii: e00374-19. doi: 10.1128/IAI.00374-19. Print 2019 Nov.
Transcriptional initiation of a small RNA, not R-loop stability, dictates the frequency of pilin antigenic variation in Neisseria gonorrhoeae.
Prister LL, Ozer EA, Cahoon LA, Seifert HS.
Mol Microbiol. 2019 Oct;112(4):1219-1234. doi: 10.1111/mmi.14356. Epub 2019 Aug 8.
Draft Genome Sequence of Pseudomonas aeruginosa Strain BWH047, a Sequence Type 235 Multidrug-Resistant Clinical Isolate Expressing High Levels of Colistin Resistance.
Bachta KER, Ozer EA, Pandit A, Marty FM, Mekalanos JJ, Hauser AR.
Microbiol Resour Announc. 2019 Jul 18;8(29). pii: e00623-19. doi: 10.1128/MRA.00623-19.
Genome-wide CRISPR screens reveal genetic mediators of cereblon modulator toxicity in primary effusion lymphoma.
Patil A, Manzano M, Gottwein E.
Blood Adv. 2019 Jul 23;3(14):2105-2117. doi: 10.1182/bloodadvances.2019031732.
Stenotrophomonas maltophilia Encodes a VirB/VirD4 Type IV Secretion System That Modulates Apoptosis in Human Cells and Promotes Competition against Heterologous Bacteria, Including Pseudomonas aeruginosa.
Nas MY, White RC, DuMont AL, Lopez AE, Cianciotto NP.
Infect Immun. 2019 Aug 21;87(9). pii: e00457-19. doi: 10.1128/IAI.00457-19. Print 2019 Sep.
The Population Structure of Pseudomonas aeruginosa Is Characterized by Genetic Isolation of exoU+ and exoS+ Lineages.
Ozer EA, Nnah E, Didelot X, Whitaker RJ, Hauser AR.
Genome Biol Evol. 2019 Jul 1;11(1):1780-1796. doi: 10.1093/gbe/evz119.
Assessing the impact, genomics and evolution of type II secretion across a large, medically important genus: the Legionella type II secretion paradigm.
White RC, Cianciotto NP.
Microb Genom. 2019 Jun;5(6). doi: 10.1099/mgen.0.000273. Epub 2019 Jun 5.
Anti-psychotic drugs block meningococcal virulence.
Seifert HS.
Nat Microbiol. 2019 Jun;4(6):906-907. doi: 10.1038/s41564-019-0467-9. No abstract available.
mTOR Dysregulation by Vaccinia Virus F17 Controls Multiple Processes with Varying Roles in Infection.
Meade N, King M, Munger J, Walsh D.
J Virol. 2019 Jul 17;93(15). pii: e00784-19. doi: 10.1128/JVI.00784-19. Print 2019 Aug 1.
RACK1 evolved species-specific multifunctionality in translational control through sequence plasticity within a loop domain.
Rollins MG, Jha S, Bartom ET, Walsh D.
J Cell Sci. 2019 Jun 19;132(12). pii: jcs228908. doi: 10.1242/jcs.228908.

View full list in PubMed

Read a message from the Chair, Laimonis A Laimins, PhD