The Satchell Lab solved the crystal structure of Ras/Rap1-specific endopeptidase (RRSP), revealing the mechanism of action of the bacterial effector.
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The Satchell Lab solved the crystal structure of Ras/Rap1-specific endopeptidase (RRSP), revealing the mechanism of action of the bacterial effector.
The Smith Lab investigates herpesvirus capsid morphogenesis and maturation.
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The Smith Lab investigates herpesvirus capsid morphogenesis and maturation.
The Laimins Lab studies the expression of DNA damage response proteins during the progression of cervical cancer.
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The Laimins Lab studies the expression of DNA damage response proteins during the progression of cervical cancer.
The Gottwein Lab investigates immunomodulatory drug effectors in primary effusion lymphoma cell lines.
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The Gottwein Lab investigates immunomodulatory drug effectors in primary effusion lymphoma cell lines.
The Seifert Lab constructed loss-of-function mutations in Neisseria gonorrhoeae genes to determine their role in bacterial physiology.
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The Seifert Lab constructed loss-of-function mutations in Neisseria gonorrhoeae genes to determine their role in bacterial physiology.
The Thimmapaya Lab studies how the PIMT RNA binding protein functions in cardiac energy metabolism.
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The Thimmapaya Lab studies how the PIMT RNA binding protein functions in cardiac energy metabolism.
The Brown Lab discusses how mast cells and innate lymphoid cells can have either disease-promoting or -protecting effects on MS and other CNS inflammatory diseases.
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The Brown Lab discusses how mast cells and innate lymphoid cells can have either disease-promoting or -protecting effects on MS and other CNS inflammatory diseases.

Seminars & Events

Jan
22
Microbiology-Immunology Department: Madeline Rollins
12:00 PM - 1:00 PM
Jan
25
Virology Journal Club
12:00 PM - 1:00 PM
Jan
29
Microbiology-Immunology Department: Joseph C. Sun, PhD
12:00 PM - 1:00 PM
Feb
5
Microbiology-Immunology Department: Denise Tarnowski
12:00 PM - 1:00 PM
Feb
7
Virology Club: Dr. Tom Hope
3:00 PM - 5:00 PM
Feb
8
Virology Journal Club
12:00 PM - 1:00 PM
Feb
12
Microbiology-Immunoogy Department: James A. Imlay, PhD
12:00 PM - 1:00 PM
Feb
22
Virology Journal Club
11:45 AM - 1:00 PM
Feb
26
Microbiology-Immunology Department:Daniel Perez
12:00 PM - 1:00 PM
Mar
1
Virology Journal Club
12:00 PM - 1:00 PM
Mar
5
Microbiology-Immunology Department: Katherine A. Radek, PhD
12:00 PM - 1:00 PM
Mar
7
Virology Club: Dr. Dean Procter
4:00 PM - 5:00 PM
Mar
8
Virology Journal Club
12:00 PM - 1:00 PM
Mar
12
Microbiology-Immunology Department: Thomas M. Krisite, PhD
12:00 PM - 1:00 PM
Mar
15
Virology Journal Club
12:00 PM - 1:00 PM
Mar
22
Virology Journal Club
12:00 PM - 1:00 PM
Mar
26
Microbiology-Immunology Department: Lubov Grigoryeva
12:00 PM - 1:00 PM
Mar
29
Virology Journal Club
12:00 PM - 1:00 PM
Apr
4
Virology Club: Dr. Gina Pisano
4:00 PM - 5:00 PM
Apr
5
Virology Journal Club
12:00 PM - 1:00 PM
Apr
12
Virology Journal Club
12:00 PM - 1:00 PM
Apr
19
Virology Journal Club
12:00 PM - 1:00 PM

News & Awards

10.11.2018Investigating Sex-Related Differences in Multiple Sclerosis
10.08.2018 Brain Tumor SPORE Drives Rapid Translation
10.05.2018Study Finds Critical Genes for Viral Lymphoma
10.01.2018Human Stem Cell Model Reveals Mechanisms of Herpes Infection
08.22.2018Experimental drug takes aim at cancers associated with Epstein-Barr virus

Our Department

We investigate mechanisms of bacterial and viral pathogenesis as well as regulation of the immune system. Our faculty members teach graduate, undergraduate and medical students at Northwestern University and the Feinberg School of Medicine. Learn more about us.

Recent Publications

Topoisomerase IIβ-binding protein 1 activates expression of E2F1 and p73 in HPV-positive cells for genome amplification upon epithelial differentiation.
Hong S, Xu J, Li Y, Andrade J, Hoover P, Kaminski PJ, Laimins LA.
Oncogene. 2019 Jan 10. doi: 10.1038/s41388-018-0633-1. [Epub ahead of print]
R-loops modulate Trypanosome antigenic variation.
Prister LL, Seifert HS.
PLoS Genet. 2018 Dec 13;14(12):e1007809. doi: 10.1371/journal.pgen.1007809. eCollection 2018 Dec. No abstract available.
Mouse Cardiac Pde1C Is a Direct Transcriptional Target of Pparα.
Shete V, Liu N, Jia Y, Viswakarma N, Reddy JK, Thimmapaya B.
Int J Mol Sci. 2018 Nov 22;19(12). pii: E3704. doi: 10.3390/ijms19123704.
Translational control during poxvirus infection.
Meade N, DiGiuseppe S, Walsh D.
Wiley Interdiscip Rev RNA. 2018 Oct 31:e1515. doi: 10.1002/wrna.1515. [Epub ahead of print] Review.
"APP"reciating the complexity of HIV-induced neurodegenerative diseases.
Naghavi MH.
PLoS Pathog. 2018 Oct 25;14(10):e1007309. doi: 10.1371/journal.ppat.1007309. eCollection 2018 Oct. No abstract available.
Natural Selection of Glycoprotein B Mutations That Rescue the Small-Plaque Phenotype of a Fusion-Impaired Herpes Simplex Virus Mutant.
Fan Q, Kopp SJ, Byskosh NC, Connolly SA, Longnecker R.
MBio. 2018 Oct 16;9(5). pii: e01948-18. doi: 10.1128/mBio.01948-18.
Neisseria gonorrhoeae Exposed to Sublethal Levels of Hydrogen Peroxide Mounts a Complex Transcriptional Response.
Quillin SJ, Hockenberry AJ, Jewett MC, Seifert HS.
mSystems. 2018 Oct 2;3(5). pii: e00156-18. doi: 10.1128/mSystems.00156-18. eCollection 2018 Sep-Oct.
RRSP and RID Effector Domains Dominate Virulence Impact of Vibrio vulnificus MARTX Toxin.
Gavin HE, Satchell KJF.
J Infect Dis. 2018 Oct 5. doi: 10.1093/infdis/jiy590. [Epub ahead of print]
The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves Ras through an atypical mechanism to disrupt Ras-ERK signaling.
Biancucci M, Minasov G, Banerjee A, Herrera A, Woida PJ, Kieffer MB, Bindu L, Abreu-Blanco M, Anderson WF, Gaponenko V, …
Sci Signal. 2018 Oct 2;11(550). pii: eaat8335. doi: 10.1126/scisignal.aat8335.
Analysis of Pilin Antigenic Variation in Neisseria meningitidis by Next-Generation Sequencing.
Xu J, Seifert HS.
J Bacteriol. 2018 Oct 23;200(22). pii: e00465-18. doi: 10.1128/JB.00465-18. Print 2018 Nov 15.
Spleen Tyrosine Kinase Inhibitor TAK-659 Prevents Splenomegaly and Tumor Development in a Murine Model of Epstein-Barr Virus-Associated Lymphoma.
Cen O, Kannan K, Huck Sappal J, Yu J, Zhang M, Arikan M, Ucur A, Ustek D, Cen Y, Gordon L, Longnecker R.
mSphere. 2018 Aug 22;3(4). pii: e00378-18. doi: 10.1128/mSphereDirect.00378-18.
Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma.
Manzano M, Patil A, Waldrop A, Dave SS, Behdad A, Gottwein E.
Nat Commun. 2018 Aug 15;9(1):3263. doi: 10.1038/s41467-018-05506-9.
Engineered Bacteria for Cholera Prophylaxis.
Satchell KJF.
Cell Host Microbe. 2018 Aug 8;24(2):192-194. doi: 10.1016/j.chom.2018.07.013.
Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit.
Meade N, Furey C, Li H, Verma R, Chai Q, Rollins MG, DiGiuseppe S, Naghavi MH, Walsh D.
Cell. 2018 Aug 23;174(5):1143-1157.e17. doi: 10.1016/j.cell.2018.06.053. Epub 2018 Aug 2.
Linking CD1-Restricted T Cells With Autoimmunity and Dyslipidemia: Lipid Levels Matter.
Bagchi S, Genardi S, Wang CR.
Front Immunol. 2018 Jul 16;9:1616. doi: 10.3389/fimmu.2018.01616. eCollection 2018. Review.
Exploitation of Cytoskeletal Networks during Early Viral Infection.
Walsh D, Naghavi MH.
Trends Microbiol. 2019 Jan;27(1):39-50. doi: 10.1016/j.tim.2018.06.008. Epub 2018 Jul 20. Review.
Expression of HPV-induced DNA Damage Repair Factors Correlates With CIN Progression.
Spriggs CC, Blanco LZ, Maniar KP, Laimins LA.
Int J Gynecol Pathol. 2019 Jan;38(1):1-10. doi: 10.1097/PGP.0000000000000477.
The Apical Region of the Herpes Simplex Virus Major Capsid Protein Promotes Capsid Maturation.
Ruhge LL, Huet AGE, Conway JF, Smith GA.
J Virol. 2018 Aug 29;92(18). pii: e00821-18. doi: 10.1128/JVI.00821-18. Print 2018 Sep 15.
ASC acts in a caspase-1-independent manner to worsen acute pneumonia caused by Pseudomonas aeruginosa.
Hughes AJ, Knoten CA, Morris AR, Hauser AR.
J Med Microbiol. 2018 Aug;67(8):1168-1180. doi: 10.1099/jmm.0.000782. Epub 2018 Jun 29.

View full list in PubMed

Read a message from the Chair, Laimonis A Laimins, PhD