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Exploring host-pathogen interactions and immunological mechanisms.

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News and Publications

Recent Publications

Vibrio MARTX toxin processing and degradation of cellular Rab GTPases by the cytotoxic effector Makes Caterpillars Floppy.

Herrera A, Packer MM, Rosas-Lemus M, Minasov G, Chen J, Brumell JH, Satchell KJF.

Proc Natl Acad Sci U S A. 2024 Jun 18;121(25):e2316143121. doi: 10.1073/pnas.2316143121. Epub 2024 Jun 11.

An attenuated lymphocytic choriomeningitis virus vector enhances tumor control in mice partly via IFN-I.

Chung YR, Awakoaiye B, Dangi T, Irani N, Fourati S, Penaloza-MacMaster P.

J Clin Invest. 2024 Jun 11:e178945. doi: 10.1172/JCI178945. Online ahead of print.

The Legionella collagen-like protein employs a distinct binding mechanism for the recognition of host glycosaminoglycans.

Rehman S, Antonovic AK, McIntire IE, Zheng H, Cleaver L, Baczynska M, Adams CO, Portlock T, Richardson K, Shaw R, Oregioni A, Mastroianni G, Whittaker SB, Kelly G, Lorenz CD, Fornili A, Cianciotto NP, Garnett JA.

Nat Commun. 2024 Jun 8;15(1):4912. doi: 10.1038/s41467-024-49255-4.

Bactericidal effectors of the Stenotrophomonas maltophilia type IV secretion system: functional definition of the nuclease TfdA and structural determination of TfcB.

Cobe BL, Dey S, Minasov G, Inniss N, Satchell KJF, Cianciotto NP.

mBio. 2024 Jun 4:e0119824. doi: 10.1128/mbio.01198-24. Online ahead of print.

Therapeutic role of interferon-γ in experimental autoimmune encephalomyelitis is mediated through a tolerogenic subset of splenic CD11b+ myeloid cells.

Arellano G, Acuña E, Loda E, Moore L, Tichauer JE, Castillo C, Vergara F, Burgos PI, Penaloza-MacMaster P, Miller SD, Naves R.

J Neuroinflammation. 2024 May 31;21(1):144. doi: 10.1186/s12974-024-03126-3.

What We Do

Welcome to the Department of Microbiology-Immunology, a basic science department at Northwestern University Feinberg School of Medicine. Our dedicated faculty are experts in the areas of bacteriology, virology and immunology and guide the training of our students and postdoctoral fellows. Learn more below.

Research

We examine pathogen-host cell interactions and dissect the molecular mechanisms involved in regulation of the immune response. 
EXPLORE OUR AREAS OF FOCUS

Education

Our faculty members also teach undergraduate, graduate and medical students at Northwestern University and Feinberg.
SEE TRAINING OPPORTUNITIES

Center for Structural Biology of Infectious Diseases

The Center for Structural Biology of Infectious Diseases (CSBID) is a consortium of laboratories using state-of-the-art, high-throughput structural biology methods to determine the three-dimensional structures of protein targets from pathogens in the NIAID Category A-C priority lists and organisms causing emerging and re-emerging infectious diseases.

VISIT THE CSBID SITE

Basic Science Administration

Our department is supported by the Basic Science Administration group. The team provides assistance related to research and financial administration, professional affairs, facilities and communications.

VISIT BASIC SCIENCE ADMINISTRATION SITE

Research Resources

We offer a wide range of resources, mentorship opportunities and training to help our residents and fellows excel as physician-scientists. Explore all of the resources and hear from housestaff who are making research a major part of their career development plans.

VISIT THE Starzl Academy Site