The Laimins Lab investigates how the transcriptional regulation activity of the TopBP1 scaffold protein influences the human papillomaviruses (HPV) life cycle.
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The Laimins Lab investigates how the transcriptional regulation activity of the TopBP1 scaffold protein influences the human papillomaviruses (HPV) life cycle.
The Walsh Lab studies the central strategies used by poxviruses to control both host and viral protein synthesis.
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The Walsh Lab studies the central strategies used by poxviruses to control both host and viral protein synthesis.
The Satchell Lab examines the contribution of effector domains to the overall virulence of the bacterial pathogen Vibrio vulnificus.
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The Satchell Lab examines the contribution of effector domains to the overall virulence of the bacterial pathogen Vibrio vulnificus.
The Naghavi and Walsh Labs study how cytoskeletal regulation contributes to the early stages of viral infection, with a primary focus on retroviruses and herpesviruses.
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The Naghavi and Walsh Labs study how cytoskeletal regulation contributes to the early stages of viral infection, with a primary focus on retroviruses and herpesviruses.
The Longnecker Lab identifies ephrin receptor A4 (EphA4) as a new target cell entry receptor for Kaposi’s sarcoma-associated herpesviru (KSHV).
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The Longnecker Lab identifies ephrin receptor A4 (EphA4) as a new target cell entry receptor for Kaposi’s sarcoma-associated herpesviru (KSHV).

Seminars & Events

Mar
22
Virology Journal Club: Kennen Hutchison (Smith Lab)
12:00 PM - 1:00 PM
Mar
26
Microbiology-Immunology Department: Catherine Putonti, PhD
12:00 PM - 1:00 PM
Mar
29
Virology Journal Club: Ajinkya Patil (Gottwein Lab) & Daniel Giraldo (Longnecker Lab)
12:00 PM - 1:00 PM
Apr
2
Microbiology-Immunology Department: Nathan Pincus
12:00 PM - 1:00 PM
Apr
4
Virology Club: Dr. Eveline Santos da Silva
4:00 PM - 5:00 PM
Apr
5
CANCELLED: Virology Journal Club: Letonia Copeland-Hardin (Gottwein Lab)
CANCELLED
Apr
12
Virology Journal Club: Colleen Furey (Walsh Lab)
12:00 PM - 1:00 PM
Apr
16
Microbiology-Immunology Department: Dean Rowe-Magnus, PhD
12:00 PM - 1:00 PM
Apr
19
Virology Journal Club: Yanique Thomas (Hope Lab)
12:00 PM - 1:00 PM
Apr
23
Microbiology-Immunology Department: Jackson Campbell
12:00 PM - 1:00 PM
Apr
26
Virology Journal Club: Qing Fan (Longnecker Lab) & Stephen DiGiuseppe (Walsh Lab)
12:00 PM - 1:00 PM
Apr
30
Microbiology-Immunology Department: Lubov Grigoryeva
12:00 PM - 1:00 PM
May
2
Virology Club: Daniel Giraldo
4:00 PM - 5:00 PM
May
3
Virology Journal Club: Nina Calantone (D'Aquila Lab)
12:00 PM - 1:00 PM
May
7
Microbiology-Immunology Department: Aron Lukacher, MD, PhD
12:00 PM - 1:00 PM
May
10
Virology Journal Club: Koree Ahn (Hope Lab)
12:00 PM - 1:00 PM
May
14
Microbiology-Immunology Department: Seo Jin Park
12:00 PM - 1:00 PM
May
17
Virology Journal Club: Kylee Morrison (Gottwein Lab) & Masato Ikeda (Longnecker Lab)
12:00 PM - 1:00 PM
May
21
Microbiology-Immunology Department: Howard Lee Weiner, MD
12:00 PM - 1:00 PM
May
23
Microbiology-Immunology Department: Spear Colloquium
2:00 PM - 3:00 PM
May
24
Virology Journal Club: Sreedhar Pujari (Laimins Lab)
12:00 PM - 1:00 PM
May
30
Microbiology-Immunology Department: Helen Blackwell, PhD
1:30 PM - 2:30 PM
May
31
Virology Journal Club
12:00 PM - 1:00 PM
Jun
6
Virology Club: Dr. Isabelle Clerc
4:00 PM - 5:00 PM

News & Awards

02.12.2019Improving Immunotherapy for Chronic Viral Infections
02.12.2019Therapeutic Toxins
02.07.2019Solving Resistance to Emerging Cancer Immunotherapy
10.11.2018Investigating Sex-Related Differences in Multiple Sclerosis
10.08.2018 Brain Tumor SPORE Drives Rapid Translation

Our Department

We investigate mechanisms of bacterial and viral pathogenesis as well as regulation of the immune system. Our faculty members teach graduate, undergraduate and medical students at Northwestern University and the Feinberg School of Medicine. Learn more about us.

Recent Publications

An Inconvenient Variable: Sex Hormones and Their Impact on T Cell Responses.
Brown MA, Su MA.
J Immunol. 2019 Apr 1;202(7):1927-1933. doi: 10.4049/jimmunol.1801403. Review.
Ephrin Receptor A4 is a New Kaposi's Sarcoma-Associated Herpesvirus Virus Entry Receptor.
Chen J, Zhang X, Schaller S, Jardetzky TS, Longnecker R.
MBio. 2019 Feb 19;10(1). pii: e02892-18. doi: 10.1128/mBio.02892-18.
Natural strain variation reveals diverse biofilm regulation in squid-colonizing Vibrio fischeri.
Rotman ER, Bultman KM, Brooks JF 2nd, Gyllborg MC, Burgos HL, Wollenberg MS, Mandel MJ.
J Bacteriol. 2019 Feb 19. pii: JB.00033-19. doi: 10.1128/JB.00033-19. [Epub ahead of print]
Analysis of Iron Requirements and Siderophore Production.
Burnside DM, Cianciotto NP.
Methods Mol Biol. 2019;1921:3-19. doi: 10.1007/978-1-4939-9048-1_1.
Topoisomerase IIβ-binding protein 1 activates expression of E2F1 and p73 in HPV-positive cells for genome amplification upon epithelial differentiation.
Hong S, Xu J, Li Y, Andrade J, Hoover P, Kaminski PJ, Laimins LA.
Oncogene. 2019 Jan 10. doi: 10.1038/s41388-018-0633-1. [Epub ahead of print]
R-loops modulate Trypanosome antigenic variation.
Prister LL, Seifert HS.
PLoS Genet. 2018 Dec 13;14(12):e1007809. doi: 10.1371/journal.pgen.1007809. eCollection 2018 Dec. No abstract available.
Mouse Cardiac Pde1C Is a Direct Transcriptional Target of Pparα.
Shete V, Liu N, Jia Y, Viswakarma N, Reddy JK, Thimmapaya B.
Int J Mol Sci. 2018 Nov 22;19(12). pii: E3704. doi: 10.3390/ijms19123704.
Translational control during poxvirus infection.
Meade N, DiGiuseppe S, Walsh D.
Wiley Interdiscip Rev RNA. 2019 Mar;10(2):e1515. doi: 10.1002/wrna.1515. Epub 2018 Oct 31. Review.
"APP"reciating the complexity of HIV-induced neurodegenerative diseases.
Naghavi MH.
PLoS Pathog. 2018 Oct 25;14(10):e1007309. doi: 10.1371/journal.ppat.1007309. eCollection 2018 Oct. No abstract available.
Natural Selection of Glycoprotein B Mutations That Rescue the Small-Plaque Phenotype of a Fusion-Impaired Herpes Simplex Virus Mutant.
Fan Q, Kopp SJ, Byskosh NC, Connolly SA, Longnecker R.
MBio. 2018 Oct 16;9(5). pii: e01948-18. doi: 10.1128/mBio.01948-18.
Neisseria gonorrhoeae Exposed to Sublethal Levels of Hydrogen Peroxide Mounts a Complex Transcriptional Response.
Quillin SJ, Hockenberry AJ, Jewett MC, Seifert HS.
mSystems. 2018 Oct 2;3(5). pii: e00156-18. doi: 10.1128/mSystems.00156-18. eCollection 2018 Sep-Oct.
RRSP and RID Effector Domains Dominate the Virulence Impact of Vibrio vulnificus MARTX Toxin.
Gavin HE, Satchell KJF.
J Infect Dis. 2019 Feb 23;219(6):889-897. doi: 10.1093/infdis/jiy590.
The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves Ras through an atypical mechanism to disrupt Ras-ERK signaling.
Biancucci M, Minasov G, Banerjee A, Herrera A, Woida PJ, Kieffer MB, Bindu L, Abreu-Blanco M, Anderson WF, Gaponenko V, …
Sci Signal. 2018 Oct 2;11(550). pii: eaat8335. doi: 10.1126/scisignal.aat8335.
Analysis of Pilin Antigenic Variation in Neisseria meningitidis by Next-Generation Sequencing.
Xu J, Seifert HS.
J Bacteriol. 2018 Oct 23;200(22). pii: e00465-18. doi: 10.1128/JB.00465-18. Print 2018 Nov 15.
Spleen Tyrosine Kinase Inhibitor TAK-659 Prevents Splenomegaly and Tumor Development in a Murine Model of Epstein-Barr Virus-Associated Lymphoma.
Cen O, Kannan K, Huck Sappal J, Yu J, Zhang M, Arikan M, Ucur A, Ustek D, Cen Y, Gordon L, Longnecker R.
mSphere. 2018 Aug 22;3(4). pii: e00378-18. doi: 10.1128/mSphereDirect.00378-18.
Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma.
Manzano M, Patil A, Waldrop A, Dave SS, Behdad A, Gottwein E.
Nat Commun. 2018 Aug 15;9(1):3263. doi: 10.1038/s41467-018-05506-9.
Engineered Bacteria for Cholera Prophylaxis.
Satchell KJF.
Cell Host Microbe. 2018 Aug 8;24(2):192-194. doi: 10.1016/j.chom.2018.07.013.
Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit.
Meade N, Furey C, Li H, Verma R, Chai Q, Rollins MG, DiGiuseppe S, Naghavi MH, Walsh D.
Cell. 2018 Aug 23;174(5):1143-1157.e17. doi: 10.1016/j.cell.2018.06.053. Epub 2018 Aug 2.
Linking CD1-Restricted T Cells With Autoimmunity and Dyslipidemia: Lipid Levels Matter.
Bagchi S, Genardi S, Wang CR.
Front Immunol. 2018 Jul 16;9:1616. doi: 10.3389/fimmu.2018.01616. eCollection 2018. Review.

View full list in PubMed

Read a message from the Chair, Laimonis A Laimins, PhD