The Laimins Lab investigates how the transcriptional regulation activity of the TopBP1 scaffold protein influences the human papillomaviruses (HPV) life cycle.
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The Laimins Lab investigates how the transcriptional regulation activity of the TopBP1 scaffold protein influences the human papillomaviruses (HPV) life cycle.
The Satchell Lab demonstrates how the Vibrio cholerae MARTX toxin simultaneously promote virulence and suppress inflammatory responses.
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The Satchell Lab demonstrates how the Vibrio cholerae MARTX toxin simultaneously promote virulence and suppress inflammatory responses.
The Hauser Lab investigates the population structure of the bacterial pathogen Pseudomonas aeruginosa.
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The Hauser Lab investigates the population structure of the bacterial pathogen Pseudomonas aeruginosa.
The Walsh Lab studies the central strategies used by poxviruses to control both host and viral protein synthesis.
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The Walsh Lab studies the central strategies used by poxviruses to control both host and viral protein synthesis.
The Cianciotto Lab studies the type II secretion system of Legionella pneumophila, the agent of Legionnaires’ disease.
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The Cianciotto Lab studies the type II secretion system of Legionella pneumophila, the agent of Legionnaires’ disease.
The Naghavi and Walsh Labs study how cytoskeletal regulation contributes to the early stages of viral infection, with a primary focus on retroviruses and herpesviruses.
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The Naghavi and Walsh Labs study how cytoskeletal regulation contributes to the early stages of viral infection, with a primary focus on retroviruses and herpesviruses.
The Longnecker Lab identifies ephrin receptor A4 (EphA4) as a new target cell entry receptor for Kaposi’s sarcoma-associated herpesviru (KSHV).
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The Longnecker Lab identifies ephrin receptor A4 (EphA4) as a new target cell entry receptor for Kaposi’s sarcoma-associated herpesviru (KSHV).

Seminars & Events

Mar
31
CANCELLED: Peptidoglycan Fragment Production by the Pathogenic Neisseria - Joseph Dillard, PhD
CANCELLED
Apr
23
Virology Club: Caitlin Pegg
4:00 PM - 5:00 PM
Apr
28
Department of Microbiology-Immunology: David Brooks, PhD
12:00 PM - 1:00 PM
May
5
Department of Microbiology-Immunology: Joseph Bondy-Denomy, PhD
12:00 PM - 1:00 PM
May
12
Department of Microbiology-Immunology: Jorge Alvarez, PhD
12:00 PM - 1:00 PM
May
14
Virology Club: Dr. Stephen DiGiuseppe
4:00 PM - 5:00 PM
May
19
Department of Microbiology-Immunology: Arash Grakoui, PhD
12:00 PM - 1:00 PM
May
26
Department of Microbiology-Immunology: Wilmara Pabon, PhD
12:00 PM - 1:00 PM
Jun
2
Department of Microbiology-Immunology: Helen Zgurskaya, PhD
12:00 PM - 1:00 PM
Jun
9
Department of Microbiology-Immunology: Hao Cell Shen, PhD
12:00 PM - 1:00 PM
Jun
11
Department of Microbiology-Immunology: Patricia A. Spear Colloquium in Virology
2:00 PM - 3:00 PM
Jun
18
Department of Microbiology-Immunology: Gregory Tyson, PhD
10:00 PM - 11:00 PM

News & Awards

03.26.2020Studying Complex Cellular Signaling Pathways
03.26.2020Drugs previously in development for SARS could be effective for COVID-19
03.19.2020New drug target found for COVID-19
03.13.2020Gold-plated Nanocrystals Could Help Fight Multiple Sclerosis
03.10.2020Debunking coronavirus myths: How COVID-19 spreads, virus testing, washing your hands, face masks

Our Department

We investigate mechanisms of bacterial and viral pathogenesis as well as regulation of the immune system. Our faculty members teach graduate, undergraduate and medical students at Northwestern University and the Feinberg School of Medicine. Learn more about us.

Recent Publications

Cellular microbiology: Bacterial toxin interference drives understanding of eukaryotic cell function.
Lemichez E, Popoff MR, Satchell KJF.
Cell Microbiol. 2020 Apr;22(4):e13178. doi: 10.1111/cmi.13178. Review.
A comparative genomics approach identifies contact-dependent growth inhibition as a virulence determinant.
Allen JP, Ozer EA, Minasov G, Shuvalova L, Kiryukhina O, Satchell KJF, Hauser AR.
Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6811-6821. doi: 10.1073/pnas.1919198117. Epub 2020 Mar 10.
Altering the Neisseria gonorrhoeae pilE Guanine Quadruplex Loop Bases Affects Pilin Antigenic Variation.
Prister LL, Yin S, Cahoon LA, Seifert HS.
Biochemistry. 2020 Mar 17;59(10):1104-1112. doi: 10.1021/acs.biochem.9b01038. Epub 2020 Feb 27.
Nanocatalytic activity of clean-surfaced, faceted nanocrystalline gold enhances remyelination in animal models of multiple sclerosis.
Robinson AP, Zhang JZ, Titus HE, Karl M, Merzliakov M, Dorfman AR, Karlik S, Stewart MG, Watt RK, Facer BD, Facer JD, …
Sci Rep. 2020 Feb 11;10(1):1936. doi: 10.1038/s41598-020-58709-w.
Systemic infection facilitates transmission of Pseudomonas aeruginosa in mice.
Bachta KER, Allen JP, Cheung BH, Chiu CH, Hauser AR.
Nat Commun. 2020 Jan 28;11(1):543. doi: 10.1038/s41467-020-14363-4.
Complete Genome Sequence of Klebsiella pneumoniae Strain TK421, a Conjugative Hypervirulent Isolate.
Kochan TJ, Ozer EA, Pincus NB, Fitzpatrick MA, Hauser AR.
Microbiol Resour Announc. 2020 Jan 16;9(3). pii: e01408-19. doi: 10.1128/MRA.01408-19.
The Vibrio cholerae MARTX toxin silences the inflammatory response to cytoskeletal damage before inducing actin cytoskeleton collapse.
Woida PJ, Satchell KJF.
Sci Signal. 2020 Jan 14;13(614). pii: eaaw9447. doi: 10.1126/scisignal.aaw9447.
TACC3 Regulates Microtubule Plus-End Dynamics and Cargo Transport in Interphase Cells.
Furey C, Jovasevic V, Walsh D.
Cell Rep. 2020 Jan 7;30(1):269-283.e6. doi: 10.1016/j.celrep.2019.12.025.
Structure of galactarate dehydratase, a new fold in an enolase involved in bacterial fitness after antibiotic treatment.
Rosas-Lemus M, Minasov G, Shuvalova L, Wawrzak Z, Kiryukhina O, Mih N, Jaroszewski L, Palsson B, Godzik A, Satchell KJF.
Protein Sci. 2020 Mar;29(3):711-722. doi: 10.1002/pro.3796. Epub 2019 Dec 17.
The Oncogenic Kaposi's Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor-Suppressive miR-15/16 miRNA Family.
Morrison K, Manzano M, Chung K, Schipma MJ, Bartom ET, Gottwein E.
Cell Rep. 2019 Dec 3;29(10):2961-2969.e6. doi: 10.1016/j.celrep.2019.11.005.
Direct Cloning Method for Expression of Recombinant Proteins with an Inositol Hexakisphosphate Inducible Self-Cleaving Tag.
Kwon K, Biancucci M, Woida PJ, Satchell KJF.
Methods Mol Biol. 2020;2091:163-179. doi: 10.1007/978-1-0716-0167-9_15.
The Cyclic AMP Receptor Protein Regulates Quorum Sensing and Global Gene Expression in Yersinia pestis during Planktonic Growth and Growth in Biofilms.
Ritzert JT, Minasov G, Embry R, Schipma MJ, Satchell KJF.
mBio. 2019 Nov 19;10(6). pii: e02613-19. doi: 10.1128/mBio.02613-19.
N-terminal autoprocessing and acetylation of multifunctional-autoprocessing repeats-in-toxins (MARTX) Makes Caterpillars Floppy-like effector is stimulated by adenosine diphosphate (ADP)-Ribosylation Factor 1 in advance of Golgi fragmentation.
Herrera A, Muroski J, Sengupta R, Nguyen HH, Agarwal S, Ogorzalek Loo RR, Mattoo S, Loo JA, Satchell KJF.
Cell Microbiol. 2020 Feb;22(2):e13133. doi: 10.1111/cmi.13133. Epub 2019 Nov 15.
Epithelial cell infection by Epstein-Barr virus.
Chen J, Longnecker R.
FEMS Microbiol Rev. 2019 Nov 1;43(6):674-683. doi: 10.1093/femsre/fuz023.
Long-term Persistence of an Extensively Drug Resistant Subclade of Globally Distributed Pseudomonas aeruginosa Clonal Complex 446 in an Academic Medical Center.
Pincus NB, Bachta KER, Ozer EA, Allen JP, Pura ON, Qi C, Rhodes NJ, Marty FM, Pandit A, Mekalanos JJ, Oliver A, …
Clin Infect Dis. 2019 Oct 4. pii: ciz973. doi: 10.1093/cid/ciz973. [Epub ahead of print]
PacBio Amplicon Sequencing Method To Measure Pilin Antigenic Variation Frequencies of Neisseria gonorrhoeae.
Ozer EA, Prister LL, Yin S, Ward BH, Ivanov S, Seifert HS.
mSphere. 2019 Oct 2;4(5). pii: e00562-19. doi: 10.1128/mSphere.00562-19.
The Herpes Simplex Virus 1 Deamidase Enhances Propagation but Is Dispensable for Retrograde Axonal Transport into the Nervous System.
Stults AM, Smith GA.
J Virol. 2019 Oct 29;93(22). pii: e01172-19. doi: 10.1128/JVI.01172-19. Print 2019 Nov 15.
Gammaherpesvirus entry and fusion: A tale how two human pathogenic viruses enter their host cells.
Möhl BS, Chen J, Longnecker R.
Adv Virus Res. 2019;104:313-343. doi: 10.1016/bs.aivir.2019.05.006. Epub 2019 Jul 17.
Type II Secretion Promotes Bacterial Growth within the Legionella-Containing Vacuole in Infected Amoebae.
White RC, Truchan HK, Zheng H, Tyson JY, Cianciotto NP.
Infect Immun. 2019 Oct 18;87(11). pii: e00374-19. doi: 10.1128/IAI.00374-19. Print 2019 Nov.

View full list in PubMed

Read a message from the Chair, Laimonis A Laimins, PhD