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Immunology

Our studies in immunology focus on understanding multiple aspects of the immune system and determining the molecular and cellular mechanisms of immunopathogenesis. Work from our immunology laboratories has led to novel discoveries on basic mechanisms of innate and adaptive immune regulation and on how infectious agents communicate with and influence the host immune system. These efforts have translated to therapeutic advances directed against diseases such as multiple sclerosis.

Labs in This Research Area

 Melissa Brown Lab

Mechanisms underlying sex-related differences in autoimmune disease; meningeal inflammation and how it impacts CNS degenerative disease

Research Description

Mast cells are found in most tissues including the gastrointestinal tract, respiratory tract, pancreas, synovium, brain, spinal cord and the secondary lymphoid organs. Best studied in the context of allergic disease, the widespread location of mast cells, the plethora of inflammatory mediators they produce and their ability to directly interact with T and B cells made them good candidates for exacerbating the inflammation associated with autoimmune diseases such as diabetes, arthritis and multiple sclerosis (MS).

We have utilized KitW/Wv mice, which are mast cell deficient, to study the contribution of these cells in a rodent model of MS, Experimental autoimmune/allergic encephalomyelitis (EAE).  EAE is characterized by the T cell mediated orchestration that damages myelin and myelin producing cells in the CNS leading to severe neurological deficits due to loss of normal nerve conduction. We have shown that mast cells in the meninges are activated early in this disease and promote the opening of the blood brain barrier (BBB), vasculature that is relatively impermeable and normally sequesters the CNS from the entry of inflammatory cells. Our current studies focus on understanding how these mast cells influence these events. In the process, we have established a new paradigm for the mast cell mediated inflammation of the meninges in immunity and believe this information will likely impact the understanding of other CNS diseases.

A second line of research investigates the development of mast cells from early myeloid precursors. Mast cells share a common precursor with a related cell type, basophils. While mast cells are resident in tissues and their numbers remain relatively stable, basophils are induced in high numbers in the blood only in certain infection settings. We have demonstrated the Ikaros, a transcription factor, is essential for proper mast cell development. In Ikaros deficient mice, mast cell development is aberrant and basophils predominate in the absence of inflammatory signals. We are studying the events that underlie mast cell basophil-lineage choice in development by examining the molecular targets of Ikaros and its mode of action under basal and infection conditions.

For lab information and more, see Dr. Brown’s faculty profile and lab website.

Publications

See Dr. Brown's publications on PubMed.

Contact

Contact Dr. Brown at 312-503-0108 or the lab at 312-503-1013.

Lab Staff

Research Faculty

Salida Mirzoeva

Postdoctoral Fellow

Rebecca Weinberg

Graduate Student

Maria Regueiro

Technical Staff

Yuchen Yang, Guiqing Zhao

 Geoff Kansas Lab

T helper cell differentiation and trafficking.

Research Description

My laboratory is interested in signaling mechanisms which control T helper cell differentiation and traffic. We are currently focused on two areas: functions of p38 MAP kinases (MAPK) and the role of a transcription factor KLF2 in these processes. Toward this end, we have produced novel mouse models which will allow us to test the role of the different isoforms of p38 (of which there are 4) in T helper differentiation and expression of key leukocyte adhesion molecules; and to determine the role of KLF2 downregulation in T helper biology generally.

For lab information and more, see Dr. Kansas's faculty profile.

Publications

See Dr. Kansas's publications on PubMed.

Contact

Contact Dr. Kansas at 312-908-3237 or the lab at 312-908-3752.

Lab Staff

Technical Staff

Caroline Patel

 Stephen Miller Lab

Elucidation of mechanisms of pathogenesis and immune regulation of autoimmune disease, allergy and tissue/organ transplantation

Research Description

The laboratory is interested in understanding the mechanisms underlying the pathogenesis and immunoregulation of T cell-mediated autoimmune diseases, allergic disease and rejection of tissue and organ transplants.  In particular, we are studying the therapeutic use of short-term administration of costimulatory molecule agonists/antagonists and specific immune tolerance induced by infusion of antigen-coupled apoptotic cells and PLG nanoparticles for the treatment of animal models of multiple sclerosis and type 1 diabetes, allergic airway disease, as well as using tolerance for specific prevention of rejection of allogeneic and xenogeneic tissue and organ transplants.

For lab information and more, see Dr. Miller's faculty profile.

Publications

See Dr. Miller's publications on PubMed.

Contact

Contact Dr. Miller at 312-503-7674 or the lab at 312-503-1449.

Lab Staff

Research Faculty

Igal IferganJoseph Podojil, Dan Xu

Adjunct Faculty

John Galvin

Postdoctoral Fellows

Gabriel Lorca, Tobias Neef, Haley Titus

Lab Manager

Valerie Eaton

Technical Staff

Sara Beddow, Ming-Yi Chiang, Lindsay Moore

Program Staff

Cynthia Naugles

Visiting Scholars

Daniel Getts

 Booki Min Lab

Regulatory T cells in inflammation

Research Description

The immune system is tightly controlled by multiple mechanisms, and Foxp3+ regulatory T (Treg) cells are prominent active regulators of immunity and tolerance. Defects in Treg cell generation or function result in uncontrolled systemic autoimmune inflammation. Despite extensive investigation in Treg cell biology, our understanding the mechanisms underlying Treg cell development and functions still remains incomplete. There is increasing evidence that Treg cell functions can be compromised under certain conditions, and such dysregulation is thought to be a contributing factor of chronic inflammatory conditions. Our laboratory studies both cellular and molecular factors that control Treg cell functions.

There are three major research projects currently underway in the laboratory.

1. IL-27 and Treg cells: Earlier studies had identified that IL-27, an immune regulatory cytokine produced by activated APCs, plays a non-redundant role in regulating Treg cell function. IL-27 acts on the IL-27 specific receptors (made of IL-27Ra and gp130 subunit) expressed on multiple cell types, primarily lymphocytes. Using various genetic approaches, our research focuses on identifying key source of IL-27 in autoimmune inflammation in the central nervous system and underlying mechanism by which IL-27 controls Treg cell function.

2. Glucocorticoids, miR-342, and Treg cells: We recently reported a novel role of Treg cells during glucocorticoid-induced treatment of chronic inflammation. In this study, we discovered a novel micro-RNA-342 molecule that is induced by steroid treatment in Treg cells and directly controls Treg cell metabolism. We are investigating the underlying mechanism by which this new micro-RNA-342 controls Treg cell function.

3. Lag3 and Treg cells: Lag3 is a new immune checkpoint molecule implicated in negatively regulating T cell functions. We discovered that Lag3 is induced by IL-27 stimulation in Treg cells and that Lag3 expression in Treg cells is critical for their suppressive function. We have generated several new mouse models in which Lag3 function and signaling pathways are targeted in a cell type specific manner. These novel animal models will allow us to dissect underlying mechanism of Lag3 in Treg cells and to identify potential therapeutic strategies not only to inhibit inflammation but also to enhance anti-tumor immunity by targeting Lag3 in Treg cells.

For lab information and more, see Dr. Min’s faculty profile.

Publications

See Dr. Min's publications.

Contact

Contact Dr. Min at 312-503-1805.

Lab Staff

Postdoctoral Fellows

Supinya Iamsawat, Dongkyun Kim

Technical Staff

Sohee Kim

 Pablo Penaloza-MacMaster Lab

Immune regulation and vaccines

Research Description

The immune system can mount a robust adaptive response following encounter with a pathogen or during the emergence of cancer. However, if an infectious microorganism  or a cancer disseminates rapidly, adaptive immune response exhaust, resulting in antigen persistence and the onset of disease. Our laboratory has demonstrated various key aspects of the exhausted immune response, including the concerted role of inhibitory pathways and T regulatory cells. In addition, we have shown the fine line between immune protection and immunopathology and our data highlight the importance of regulating helper CD4 T cell function during antigen persistence.

Overall, our main interests are vaccines and immune regulation during antigen persistence. We utilize various systems to assess immune responses (LCMV, Listeria, vaccinia, adenovirus, tumor challenge models, as well as the humanized mouse model of HIV infection and the SIV infection model in macaques). We hope that our basic immunological research can one day translate into effective treatments against cancers and chronic infections (such as HIV), which affect millions of people worldwide.

For lab information and more, see Dr. Penaloza-MacMaster's faculty profile.

Publications

See Dr. Penaloza-MacMaster's publications on PubMed.

Contact

Contact Dr. Penaloza-MacMaster at 312-503-0357.

Lab Staff

Postdoctoral Fellow

Tanushree Dangi, Juan Loredo Varela

Graduate Student

Young Rock Chung, Nicole Palacio

 Chyung-Ru Wang Lab

Antigen Presentation, T-Cell Development and Regulation, Infectious Diseases and Autoimmune Diseases

Research Description

Our lab focuses on two of the MHC class Ib molecules, H2-M3 and CD1. These molecules have unusual binding specificity for antigens that are conserved in bacteria. H2-M3 presents N-formylated peptides to cytotoxic T cells while CD1 presents lipid antigens to several distinct subsets of T cells. The high degree of conservation of these microbial antigens combined with the limited polymorphism of M3 and CD1 make these two molecules attractive targets for T-cell based vaccines against intracellular pathogens for a genetically diverse population. We have generated several animal models to examine the roles of M3 and CD1 in T cell development, autoimmune diseases and defense against infectious agents, including Listeria monocytogenes and Mycobacterium tuberculosis. Using these model systems, we study the mechanisms that regulate the selection and in vivo function of M3-restricted and CD1-restricted T cells. Additionally, these models are used to characterize novel microbial antigens recognized by MHC class Ib-restricted T cells. Studies on this relatively uncharacterized segment of the mammalian immunologic repertoire may lead to improved methods for vaccination against infectious diseases.

For lab information and more, see Dr. Wang's faculty profile.

Publications

See Dr. Wang's publications on PubMed.

Contact

Contact Dr. Wang at 312-503-9748 or the lab at 312-503-1093.

Lab Staff

Postdoctoral Fellows

Liang Cao, Yongyong Cui, Yen-Lin Lin, Shaobin Shang, Lavanya Visvabharathy

Graduate Students

Samantha Genardi, Eva Morgun

Technical Staff

Ying He, Shon Thomas