Ali Shilatifard, PhD

Recipient of the 2022 National Cancer Institute Outstanding Investigator Award

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Kimberly Querrey, Louis Simpson Trust Give $100 Million to Feinberg

Transformational gift will significantly expand the University’s biomedical research enterprise

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Jennifer Doudna, PhD

CRISPR pioneer receives inaugural Kimberly Prize

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Scientists Discover Novel Cellular Mechanisms Behind Transcription Elongation

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Recent Faculty Promotions

See the latest Biochemistry & Molecular Genetics faculty members to be promoted

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Our Mission

Epigenetic-driven insights are proving to be fundamental to a myriad of diseases including cancer, heart, immunologic and neurological conditions. The mission of the Simpson Querrey Institute for Epigenetics at Northwestern University Feinberg School of Medicine is the investigation of the link between environmental factors in the regulation of the expression of genes packaged within our chromatin. Such studies shall define how the misregulation of epigenetic processes can result in pathological conditions and how we can take advantage of such molecular information for developing treatments through targeted therapeutics.

We will work very hard to develop a deeper molecular understanding of the machinery involved in the regulation of epigenetics with an eye for developing targeted therapeutics for the treatment of diseases due to epigenetic abnormalities. These efforts, we expect, shall lead to more personalized medicine and a better quality of life."

– Ali Shilatifard, PhD, the Robert Francis Furchgott Professor and chair of Biochemistry and Molecular Genetics, Institute Director

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Research

The institute brings together experts in biochemistry, molecular genetics, computational biology, fundamental biology, epidemiology and clinical medicine to develop foundational insights about how environmental conditions – including emotional experiences, chemical exposure, obesity, exercise, diet and drug therapies – impact the human genome using sophisticated molecular, biochemical and computational methods.

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Featured Stories

SQE Membership

<p>Members of Northwestern University’s Simpson Querrey Center for Epigenetics (SQE) receive invitations to join faculty from both campuses in coming together to engage in collaborative discussions at regularly hosted seminars and events. Membership is open to all faculty, clinicians, students and staff.</p><p><a class="button" href="https://forms.feinberg.northwestern.edu/view.php?id=444276">Become a Member</a></p>

Members of Northwestern University’s Simpson Querrey Institute for Epigenetics (SQE) receive invitations to join faculty from both campuses in coming together to engage in collaborative discussions at regularly hosted seminars and events. Membership is open to all faculty, clinicians, students and staff.

Become a Member

Understanding Epigenetics

<p>Watch this original animation, which explains chromatin biology, epigenetics and the regulation of gene activity.</p><p><a class="button" href="https://youtu.be/XelGO582s4U">Watch Video</a></p>

Chromatin Biology

Watch this original animation, which explains chromatin biology, epigenetics and the regulation of gene activity.

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The Simpson Querrey Institute for Epigenetics

We study the effects of environment on the activation and expression of genes.

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About Our Name

Our work is supported by the generosity of university trustees and supporters Kimberly K. Querrey and the late Louis A. Simpson ’58. For more than a decade, Simpson and Querrey have consistently supported Northwestern and made possible many strategic initiatives, including the Louis A. Simpson and Kimberly K. Querrey Biomedical Research Center, a 14-story, 600,000-square-foot building that significantly expanded Feinberg’s biomedical research enterprise.

About the Research Center

Our work is supported by the generosity of University trustees and supporters Louis A. Simpson ’58 and Kimberly K. Querrey. For more than a decade, Simpson and Querrey have consistently supported Northwestern and made possible many strategic initiatives, including the forthcoming <a href="https://www.feinberg.northwestern.edu/sites/simpson-querrey/">Louis A. Simpson and Kimberly K. Querrey Biomedical Research Center</a>, a 14-story, 600,000-square-foot building that will significantly expand Feinberg’s biomedical research enterprise.

Spotlights

Marc Mendill, PhD

Marc Mendillo, PhD

Assistant Professor Marc Mendillo, PhD recieves NIH/NIGMS R01 grant. Title: Regulation and interplay of Heat Shock Factors in growth-associated proteotoxic stresses

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Clara Peek, PhD

Clara Peek, PhD

Assistant Professor Clara Peek, PhD recieves NIH/NIDDK R01 grant. Title: Clock Control of Muscle Glucose Metabolism and HIF Activity

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Lillian Eichner, PhD

Lillian Eichner, PhD

Assistant Professor Lillian Eichner, PhD recieves the NCI Transition Career Development Award (K22)

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L Wang, PhD

Lu Wang, PhD

Assistant Professor Lu Wang, PhD recieves NIGMS Maximizing Investigators’ Research Award (MIRA) (R35)

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Issam Ben-Sahra, PhD

Issam Ben-Sahra, PhD

Assistant Professor Issam Ben-Sahra, PhD recieves NIH/NIGMS R01 grant funding. Title: Regulation of de novo purine synthesis by the MAPK/ERK pathway

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Mara Iwanaszk, PhD

Marta Iwanaszko, PhD

Research Assistant Professor Marta Iwanaszko, PhD recieves NCI R50 funding. Title: Computational Approaches for Studying Transcription Elongation Control in Cancer

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Sephen Lander

Stephen Lander

G3 MD/PhD student receives the NIH Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (Parent F31-Diversity) grant. The title of the project is “Elucidating mechanisms of acetylcholine signaling in bacterial biofilms”. 

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Elizabeh McNally, MD/PhD

Elizabeth McNally, MD/PhD

Elected to the National Academy of Medicine.

Feng Ye, PhD

Feng Yue, PhD

Honored at investiture ceremony for endowed professorship.

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