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Northwestern University Feinberg School of Medicine
Simpson Querrey Center for Epigenetics

Center for Epigenetics

We study the effects of environment on the activation and expression of genes.

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Our Mission

Epigenetic-driven insights are proving to be fundamental to a myriad of diseases including cancer, heart, immunologic and neurological conditions. The mission of the Simpson Querrey Center for Epigenetics at Northwestern University Feinberg School of Medicine is the investigation of the link between environmental factors in the regulation of the expression of genes packaged within our chromatin. Such studies shall define how the misregulation of epigenetic processes can result in pathological conditions and how we can take advantage of such molecular information for developing treatments through targeted therapeutics.

“We will work very hard to develop a deeper molecular understanding of the machinery involved in the regulation of epigenetics with an eye for developing targeted therapeutics for the treatment of diseases due to epigenetic abnormalities. These efforts, we expect, shall lead to more personalized medicine and a better quality of life.”

– Ali Shilatifard, PhD, the Robert Francis Furchgott Professor and chair of Biochemistry and Molecular Genetics, Center Director

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The center brings together experts in biochemistry, molecular genetics, computational biology, fundamental biology, epidemiology and clinical medicine to develop foundational insights about how environmental conditions – including emotional experiences, chemical exposure, obesity, exercise, diet and drug therapies – impact the human genome using sophisticated molecular, biochemical and computational methods.

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Featured Stories

Members of Northwestern University’s Simpson Querrey Center for Epigentics (SQE) receive invitations to join faculty from both campuses in coming together to engage in collaborative discussions at regularly hosted seminars and events. Membership is open to all faculty, clinicians, students and staff.

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Understanding Epigenetics

Chromatin Biology

Watch this original animation, which explains chromatin biology, epigenetics and the regulation of gene activity.

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About Our Name

Our work is supported by the generosity of University trustees and supporters Louis A. Simpson ’58 and Kimberly K. Querrey. For more than a decade, Simpson and Querrey have consistently supported Northwestern and made possible many strategic initiatives, including the forthcoming Louis A. Simpson and Kimberly K. Querrey Biomedical Research Center, a 14-story, 600,000-square-foot building that will significantly expand Feinberg’s biomedical research enterprise.

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