Education & Seminars

Our members are active member of the Feinberg community, speaking at and participating in a number of educational events around campus on a variety of epigentics-related topics.

Use the tabs below to browse listings of upcoming genetics-related seminars and events. For a schedule of additional Northwestern University and Feinberg School of Medicine events, visit the Feinberg Medical School Event Calendar or PlanIt Purple.

Feb

09

SQE Lecture Series: "Epigenetics of Early Development" with Nicola Iovino, PhD

Chicago - 1:30 PM - 2:30 PM

The Simpson Querrey Institute for Epigenetics presents:

Nicola Iovino, PhD

Group Leader, Chromatin Regulation
Max Planck Institute, Freiburg, Germany

"Epigenetics of Early Development"

Fertilization occurs when the two gametes, after epigenetic reprogramming, fuse to produce a totipotent zygote. Although any defects in gametes’ reprogramming can cause infertility, the mechanisms underlying this process remain poorly understood.
My lab focuses on fundamental and translational aspects of chromatin biology in germ cells and early embryogenesis. We combine Drosophila genetics with mouse models to investigate three main lines of research: (i) germline inheritance of chromatin states, (ii) assembly and maturation of chromatin after fertilization (iii) 3D genome reorganization in early embryos. We showed that the H3K27me3 repressive histone mark is retained on post-meiotic oocytes. It is intergenerationally transmitted from the germline to the next generation showing for the first time that epigenetic information is also germline inherited and essential to regulate gene expression in the offspring. We could further show that de novo deposited histone variants and histone acetylation also regulate gene expression in the early embryo, revealing a completely unanticipated role for histone modification-mediated gene regulation at this developmental stage. In the early embryo, the nucleus is also organized de novo in a complex hierarchical folding pattern, including chromatin loops, topologically associating domains (TADs), and compartmental domains. We discovered a novel and fundamental role for HP1a in chromatin reorganization after fertilization. We showed that HP1a i) controls the general folding of chromosome arms, ii) controls the clustering and compaction of heterochromatic pericentromeric regions, and iii) contributes to the formation of the B compartment. In the long run, my lab will dissect the complete network that regulates chromatin remodelling in the early embryo in physiological and stressed conditions. Our investigations will reveal novel insights into the first steps in the formation of life and ultimately advance reproductive and regenerative medicine.


Selected references from my lab:
Zenk F., Zhan Y., et al. (2021) HP1 drives de novo 3D genome reorganization in early Drosophila embryos. Nature 593, 289–293
Ibarra-Morales D., et. Al. (2021) Histone variant H2AZ regulates zygotic genome activation.
Nature Communications 12, Article number: 7002 (2021)
Skvortsova K., et al (2018) Functions and mechanisms of epigenetic inheritance in animals. Nat Rev Mol Cell Biol.19(12):774-790
Zenk F., et al. (2017) Germ line–inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition. Science 6347, 212-216
Iovino N. (2014) Drosophila epigenome reorganization during oocyte differentiation and early embryogenesis. Brief Funct Genomics 13, 246-253.
Iovino N., et al. (2013) PRC2 controls Drosophila oocyte cell fate by repressing cell cycle genes. Dev Cell 26, 431-439.

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Feb

17

SQE Distinguished Lecturer Series: "Deciphering the Mechanisms and Roles of DNA Methylation in Cancer" with Peter A. Jones, PhD

Chicago - 10:00 AM - 11:00 AM

The Simpson Querrey Institute for Epigenetics presents:

Peter Jones, PhD, DSc (hon)

Chief Scientific Officer
Van Andel Institute, Grand Rapids, MI

"Deciphering the Mechanisms and Roles of DNA Methylation in Cancer"

DNA methylation is essential for mammalian embryonic and post-natal development. Mutations in the de novo DNA methyltransferase DNMT3A, which is expressed as two isoforms, DNMT3A1 and DNMT3A2, cause abnormal brain development in children and clonal hematopoiesis in older individuals. Additionally, DNA methylation patterns are profoundly altered in all human cancers in the absence of mutations in the components of the methylation machinery. We have discovered that a large majority of human tumors overexpress the DNMT3A2 isoform and have determined the cryo-EM structure of this isoform together with its non-catalytically active accessory protein, DNMT3B3 bound to a nucleosome. Unexpectedly, the heterotetrameric complex binds to the acidic patch present on all nucleosomes raising questions as to how specificity of methylation is obtained. As part of our work to define how DNA methylation is interpreted by DNA binding proteins, we investigated the influence of hemimethylation of CpG sites altered binding of CTCF. We were very surprised to find that while methylation of the motif strand inhibited binding as predicted, methylation on the opposite strand stimulated binding. The inherent asymmetry of hemimethylation may have consequences for stem cell differentiation. I will also discuss the development of new drugs and combinations to target abnormal methylation in cancer and present results of small clinical trials in patients to test these approaches. 

 

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Feb

17

Simpson Querrey Institute for Epigenetics Forum on Biochemistry, Epigenetics, and Metabolism (BEaM)

Chicago - 1:00 PM - 2:00 PM

Presenter:

Alexander Lee, DGP Graduate Student, Biochemistry and Molecular Genetics, Foltz/Kelleher Labs

Presentation: “ Comprehensive Interactome Profiling of Replication Stress Response and Centromere Instability” 

The BEaM Forum is a data group where Simpson Querrey Institute for Epigenetics members present ongoing work being conducted. It is a great opportunity to get feedback on your work from colleagues, and to make new connections and foster new collaborations within the Institute. 

Our forum will normally be held every other week from 1:00-2:00 p.m. Presenters will give a 20-minute talk with 10 minutes for discussion and questions. We welcome presentation from students, techs, postdocs, and PIs. Presenting work-in-progress is always encouraged!

Pizza and soda provided.

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Feb

28

Simpson Querrey Institute for Epigenetics Lecture Series: Karim-Jean Armache, PhD, NYU Grossman School of Medicine

Chicago - 10:00 AM - 11:00 AM

The Simpson Querrey Institute for Epigenetics presents:

Karim-Jean Armache, PhD

Associate Professor
Department of Biochemistry and Molecular Pharmacology
NYU Grossman School of Medicine, NY

 

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Mar

03

Simpson Querrey Institute for Epigenetics Forum on Biochemistry, Epigenetics, and Metabolism (BEaM)

Chicago - 1:00 PM - 2:00 PM

Presenter:

Sakshi Khurana, DGP Graduate Student, Biochemistry and Molecular Genetics, Foltz Lab

The BEaM Forum is a data group where Simpson Querrey Institute for Epigenetics members present ongoing work being conducted. It is a great opportunity to get feedback on your work from colleagues, and to make new connections and foster new collaborations within the Institute. 

Our forum will normally be held every other week from 1:00-2:00 p.m. Presenters will give a 20-minute talk with 10 minutes for discussion and questions. We welcome presentation from students, techs, postdocs, and PIs. Presenting work-in-progress is always encouraged!

Pizza and soda provided.

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Mar

07

SQE Distinguished Lecturer Series: "Coordinated Control of Coding and Non-Coding Transcription" with Karen Adelman, PhD

Chicago - 10:00 AM - 11:00 AM

The Simpson Querrey Institute for Epigenetics presents:

Karen Adelman, PhD

Professor of Biological Chemistry and Molecular Pharmacology
Blavatnik Institute
Harvard Medical School

"Coordinated Control of Coding and Non-Coding Transcription"

The transition of RNA polymerase II (Pol II) from initiation to productive elongation is a central, regulated step in metazoan gene expression. At many genes, Pol II pauses stably in early elongation, remaining engaged with the 25-60 nucleotide-long nascent RNA for many minutes while awaiting signals for release into the gene body. However, paused Pol II is unstable at a number of genes and a majority of enhancers, suggesting that promoter-proximal Pol II can be actively targeted for premature termination. Notably, such termination of Pol II releases a short, non-productive RNA, effectively short-circuiting the process of gene expression. 

I will discuss our recent work investigating the decision between productive elongation vs. termination of Pol II near gene promoters and how this choice is made differently at enhancers. I will discuss the role of the Integrator complex in premature termination, and how elongation factors modulate Pol II activity.

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Mar

17

Simpson Querrey Institute for Epigenetics Forum on Biochemistry, Epigenetics, and Metabolism (BEaM)

Chicago - 1:00 PM - 2:00 PM

Presenters:

Farzaneh Sharifzad, Postdoctoral Fellow, Urology, Thumbikat Lab

Eunus S. Ali, Postdoctoral Scholar, Biochemistry and Molecular Genetics, Ben-Sahra Lab

The BEaM Forum is a data group where Simpson Querrey Institute for Epigenetics members present ongoing work being conducted. It is a great opportunity to get feedback on your work from colleagues, and to make new connections and foster new collaborations within the Institute. 

Our forum will normally be held every other week from 1:00-2:00 p.m. Presenters will give a 20-minute talk with 10 minutes for discussion and questions. We welcome presentation from students, techs, postdocs, and PIs. Presenting work-in-progress is always encouraged!

Pizza and soda provided.

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Mar

27

SQE Distinguished Lecturer: Benjamin G. Neel, PhD, NYU School of Medicine, NYC

Chicago - 10:00 AM - 11:00 AM

The Simpson Querrey Institute for Epigenetics presents:

Benjamin G. Neel, PhD

Professor of Medicine, NYU School of Medicine
Director, Laura and Isaac Perlmutter Cancer Center, NYC

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Apr

14

Simpson Querrey Institute for Epigenetics Forum on Biochemistry, Epigenetics, and Metabolism (BEaM)

Chicago - 1:00 PM - 2:00 PM

Presenters:

Austin Klein, DGP Graduate Student, Biochemistry and Molecular Genetics, Mendillo Lab

Mushtaq Nengroo, Postdoctoral Fellow, Biochemistry and Molecular Genetics, Mendillo/Ben-Sahra Lab

The BEaM Forum is a data group where Simpson Querrey Institute for Epigenetics members present ongoing work being conducted. It is a great opportunity to get feedback on your work from colleagues, and to make new connections and foster new collaborations within the Institute. 

Our forum will normally be held every other week from 1:00-2:00 p.m. Presenters will give a 20-minute talk with 10 minutes for discussion and questions. We welcome presentation from students, techs, postdocs, and PIs. Presenting work-in-progress is always encouraged!

Pizza and soda provided.

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Apr

17

SQE Distinguished Lecturer: Giacomo Cavalli, PhD, Université de Montpellier, France

Chicago - 10:00 AM - 11:00 AM

The Simpson Querrey Institute for Epigenetics presents:

Giacomo Cavalli, PhD

Director, Chromatin and Cell Biology Lab, Institute of Human Genetics, Université de Montpellier, France

"The Role of 3D Genome Organization and Polycomb Proteins in Cell Differentation and Development"

The eukaryotic genome folds in 3D in a hierarchy of structures, including nucleosomes, chromatin fibers, loops, chromatin nanodomains, topologically associating domains (TADs), compartments and chromosome territories that are highly organized in order to allow for stable memory as well as for regulatory plasticity, depending on intrinsic cues, such as chromatin association of Polycomb proteins, CTCF and cohesion, and on environmental cues. We showed that TADs and chromatin loops can assist gene regulation, both in Drosophila and in mouse cells. However, the physical nature of compartments, TADs and loops remain elusive and single-cell studies are critically required to understand it. We characterized chromatin folding in single cells using super-resolution microscopy, revealing structural features inaccessible to cell-population analysis. TADs range from condensed and globular objects to stretched conformations. Favored interactions within TADs are regulated by cohesin and CTCF through distinct mechanisms. Furthermore, super-resolution imaging revealed that TADs are subdivided into discrete nanodomains. 

We also analyzed loops that depend on chromatin components that regulate the expression of a large number of genes, dubbed as Polycomb group proteins. Originally, these factors were shown to silence gene expression and we found that they induce the formation of chromatin loops. The disruption of one of these loops reduces silencing of a target genes, suggesting that loops may play instructive roles in gene regulation. Surprisingly, Polycomb components are also involves in chromatin loops linked with transcriptional activation. Furthermore, their chromatin organization ability can induce stable epigenetic memory that can be inherited through cell division and across organismal generations. Our progress in these fields will be discussed.

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Apr

25

SQE Distinguished Lecturer: Sankar Ghosh, PhD, Columbia University, NYC

Chicago - 10:00 AM - 11:00 AM

The Simpson Querrey Institute for Epigenetics presents:

Sankar Ghosh, PhD

Silverstein and Hutt Family Professor and Chairman, Department of Microbiology and Immunology, Columbia University, NYC

 

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Apr

28

Simpson Querrey Institute for Epigenetics Forum on Biochemistry, Epigenetics, and Metabolism (BEaM)

Chicago - 1:00 PM - 2:00 PM

Presenters:

Juan Wang, PhD Candidate, Biochemistry and Molecular Genetics, Yue Lab

Pranathi Vadlamani, DGP Graduate Student, Biochemistry and Molecular Genetics, Foltz Lab

The BEaM Forum is a data group where Simpson Querrey Institute for Epigenetics members present ongoing work being conducted. It is a great opportunity to get feedback on your work from colleagues, and to make new connections and foster new collaborations within the Institute. 

Our forum will normally be held every other week from 1:00-2:00 p.m. Presenters will give a 20-minute talk with 10 minutes for discussion and questions. We welcome presentation from students, techs, postdocs, and PIs. Presenting work-in-progress is always encouraged!

Pizza and soda provided.

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May

01

SQE Distinguished Lecturer: Genevieve Almouzni, PhD, Institut Curie, France

Chicago - 10:00 AM - 11:00 AM

The Simpson Querrey Institute for Epigenetics presents:

Genevieve Almounzni, PhD

Team Leader, Chromatin Dynamics
Institut Curie, France

"Histone Variants and Chaperones in Shaping Chromatin and Cell Fate"

Chromatin organization in the nucleus provides a large repertoire of information in addition to that encoded genetically. A major goal for my group involves understanding how histones, the major protein components of chromatin, the bricks, can mark functional regions of the genome through their variants or post-translational modifications, along with non-coding RNA and other chromatin regulators. Errors in the establishment and propagation of these chromatin components, possibly involving imbalance in their deposition pathways, can lead to mis-regulation of genome functions and pathological outcomes, such as cancer. The propagation of chromatin states is central in the study of epigenetic mechanisms. Our work has focused on histone chaperones, as architects of chromatin organization and key chromatin determinants. We will present our latest findings on this topic with a focus on H3 variants and their links with cell fate transitions.”

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May

08

SQE Distinguished Lecturer: Huda Yahya Zoghbi, MD, Baylor College of Medicine

Chicago - 10:00 AM - 11:00 AM

The Simpson Querrey Institute for Epigenetics presents:

Huda Yahya Zoghbi, MD

Investigator, Howard Hughes Medical Institute
Director, Jan and Dan Duncan Neurological Research Institute
Distinguished Service Professor, Baylor College of Medicine

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Feb

09

BMG Seminar: G.R. Scott Budinger, MD, Northwestern University Feinberg School of Medicine

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry & Molecular Genetics presents:

GR Scott Budinger, MD
Chief of Pulmonary and Critical Care in the Department of Medicine
Ernest S. Bazley Professor of Airway Diseases
Professor of Medicine (Pulmonary and Critical Care) and Cell and Developmental Biology
Northwestern University Feinberg School of Medicine

Presentation: 

“Lessons from the pandemic: Distinctive features of SARS-CoV-2 pneumonia”

 

Host: Dr. Ali Shilatifard, Chairman, Department of Biochemistry and Molecular Genetics

 

 

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Feb

10

CANCELLED - BMG Journal Club

Chicago - 1:00 PM - 2:00 PM

The BMG Journal Club is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience.

 

 

 

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Feb

16

BMG Seminar: Danwei Huangfu, PhD, Sloan Kettering Institute, New York, NY

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry & Molecular Genetics presents:

Danwei Huangfu, PhD
Member and Professor, Developmental Biology Program
Sloan Kettering Institute

Presentation:

"A stem cell approach to human development, from reconstitution to deconstruction using CRISPR screens"

Abstract: 

The Huangfu lab interrogates human development and disease mechanisms through combining genome editing tools with stem cell technology. They have led the development of efficient genome editing tools in human pluripotent stem cells (hPSCs), and further implemented these tools to interrogate pancreatic development and diabetes mechanisms through the studies of hPSC-derived pancreatic progenitors and islet-like organoids. They have further spearheaded CRISPR-Cas9 genome-scale knockout screening approach to identify novel genetic regulators of hPSC differentiation, an approach they have extended to the discovery of regulators of DNA methylation.

Host: Dr. Feng Yue, Professor of Biochemistry and Molecular Genetics and Pathology

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Feb

24

BMG Journal Club: Iris Liu, MS and Aileen Szczepanski

Chicago - 1:00 PM - 2:00 PM

Presenters:

Aileen Szczepanski, Research Technologist II, Biochemistry and Molecular Genetics, Wang Lab

and

Iris Liu, MS, DGP Graduate Student, Medicine (Pulmonary and Criticl Care), Singer Lab

Presentation: "SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry"

https://pubmed.ncbi.nlm.nih.gov/36198800/

The BMG Journal Club is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience.

Refreshments will be provided.

 

 

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Mar

02

BMG Seminar: James A. Olzmann, PhD, University of California, Berkeley

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry & Molecular Genetics presents:

James A. Olzmann
Associate Professor
Departments of Molecular & Cell Biology and Nutritional Sciences & Toxicology
University of California, Berkeley 

Presentation:

"Mechanisms of lipid quality control and ferroptosis"
 

Hosts: Dr. Issam Ben-Sahra, Assistant Professor of Biochemistry and Molecular Genetics and Dr. Naveep S. Chandel, Professor of Medicine (Pulmonary and Critical Care) and Biochemistry and Molecular Genetics

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Mar

09

BMG Seminar: Kapil Bhalla, MD, University of Texas MD Anderson Cancer Center, Houston, TX

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry and Molecular Genetics presents:

Kapil Bhalla, MD
Professor, Department of Leukemia, Division of Cancer Medicine and Kelcie Kana Research Chair
University of Texas, MD Anderson Cancer Center

Presentation:

"Improving efficacy and overcoming resistance to Menin inhibitor therapy in AML with MLL1r or NPM1 mutation"

Abstract: In MLL1 rearranged (MLL1r) AML (~10%), N-terminus of MLL1 gene is fused to the C-terminus of a fusion partner, e.g. AF9, AF4, ENL and ELL, creating MLL1 fusion protein (MLL-FP), which increases expression of leukemogenic HOXA9 and its co-factor MEIS1. In AML with mutant (mt) NPM1 (NPM1c), MLL1 is the main driver of HOXA9, MEIS1 and FLT3, promoting self-renewal and growth of AML stem-progenitor cells (LSCs). Treatment with Menin inhibitor (MI), SNDX-50469 or SNDX-5613, disrupts binding of Menin to its binding pocket in MLL1/2 and MLL1-FP, reducing expressions of their targets and inducing differentiation and apoptosis. In the phase I/II AUGMENT-101 clinical trial, SNDX-5613 monotherapy was well tolerated and achieved objective remissions in patients with previously treated relapsed/refractory AML harboring MLL1r or NPM1c. However, majority of patients either fail to respond or eventually relapse. A minority of MLL1r AML (~9%) also exhibit a co-mutation in TP53, which is known to confer therapy resistance and poor outcome in AML. This creates the need to develop MI-based synergistic combinations with superior efficacy against patient-derived (PD) AML cells harboring MLL-FP or NPM1c. In present studies, utilizing, CyTOF analysis of PD MLL1-r and NPM1c AML cells following MI showed decline in protein levels of Menin, MEIS1, MEF2C, PBX3, FLT3, CDK6 and BCL2 in phenotypically characterized AML LSCs expressing CLEC12A, CD123, CD244 and CD99. Notably, in vitro co-treatment with SNDX-50469 in combination with venetoclax, pan-BET inhibitor or abemaciclib (CDK6 inhibitor) induced synergistic loss of viability in AML cell lines and in PD AML cells with MLL-r or NPM1c, as well as in MOLM13 cells with CRISPR-Cas9-mediated knock-in of mutant or allelic loss of TP53, but not in normal CD34+ progenitor cells or AML cells lacking MLL-FP or NPM1c. A CRISPR screen with a validated, domain-specific gRNA library against chromatin regulators revealed BRD4, p300, MOZ and KDM1A as druggable co-dependencies with treatment with MI. Consistent with this, co-treatment with SNDX-50469 and OTX015, or the p300/CBP inhibitor GNE049 was synergistically lethal in vitro in AML cells with MLL1r or NPM1c, either sensitive to MI or tolerant-resistant (induced in vitro) to MI (MITR cells). Co-treatment with SNDX-5613 and venetoclax or OTX015 compared to each drug or vehicle control, administered orally for 3 to 4 weeks to NSG mice engrafted with either MOLM13-GFP/Luciferase xenograft or with PD NPM1c and mtFLT3 AML xenograft, caused significantly greater reduction in AML burden and increased overall survival without weight loss or other toxicities. These preclinical findings highlight novel MI-based combinations exhibiting superior in vitro and in vivo anti-AML efficacy against AML cells harboring MLL1-FP or NPM1c that are sensitive or resistance to MI. 

Host: Dr. Lu Wang, Assistant Professor, Biochemistry and Molecular Genetics

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Mar

10

BMG Journal Club: Ye Hou, PhD and Mushtaq Ahmad Nengroo, PhD

Chicago - 1:00 PM - 2:00 PM

Presenters:

Mushtaq Ahmad Nengroo, PhD, Postdoctoral Fellow, Biochemistry and Molecular Genetics, Ben-Sahra Lab

Ye Hou, PhD, Postdoctoral Fellow, Biochemistry and Molecular Genetics, Yue Lab

The BMG Journal Club is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience.

Refreshments will be provided.

 

 

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Mar

16

BMG Seminar: Gerta Hoxhaj, PhD, UT Southwestern Medical Center, Dallas, TX

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry & Molecular Genetics presents:

Gerta Hoxhaj, Ph.D.
Assistant Professor 
Children’s Research Institute and Department of Biochemistry 
University of Texas Southwestern Medical Center 

Presentation:

"REGULATION AND FUNCTION OF NADPH METABOLISM IN CELL GROWTH"

Abstract:

NADPH is the major reducing currency that drives the synthesis of macromolecules and fuels the antioxidant systems to protect cells from oxidative stress. Dysregulation of NADPH metabolism has been linked to many human pathologies, including cancer, neurodegeneration, and aging, yet regulation of this process remains poorly understood. NADPH levels are determined by NAD kinases (NADKs) - metabolite kinases that phosphorylate NAD+ molecules to make NADP+ (oxidized form of NADPH), a limiting substrate for NADPH generation. Human cells encode two NADKs: cytosolic NADK and mitochondrial NADK2, which provide reducing power in each cell compartment. Using NAD kinases as a tool to modulate specific NADPH pools, our research efforts are focused on understanding how cells and organisms control and regulate compartment-specific NADPH metabolism. Our ultimate goal is to exploit vulnerabilities in NADPH metabolism to treat disease.

Hosts: Dr. Issam Ben-Sahra, Assistant Professor of Biochemistry and Molecular Genetics and Dr. Naveep S. Chandel, Professor of Medicine (Pulmonary and Critical Care) and Biochemistry and Molecular Genetics

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Mar

24

BMG Journal Club: Alexander Lee and Shimaa Soliman, PhD

Chicago - 1:00 PM - 2:00 PM

Presenters:

Alexander Lee, PhD Candidate, Biochemistry and Molecular Genetics, Kelleher and Foltz Labs

Shimaa Soliman, PhD, Postdoctoral Fellow, Biochemistry and Molecular Genetics, Shilatifard Lab

The BMG Journal Club is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience.

Refreshments will be provided.

 

 

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Apr

06

BMG Seminar: Jason Gestwicki, PhD, University of California San Francisco (UCSF)

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry & Molecular Genetics presents:

Jason Gestwicki, PhD
Professor, Department of Pharmaceutical Chemistry
Associate Director of the Institute for Neurodegenerative Diseases
University of California San Francisco (UCSF)

Presentation:

"Targeting Protein-Protein Interactions to Treat Protein Misfolding Diseases"

Abstract:

To maintain protein homeostasis (proteostasis), each cell must carefully balance the decision to retain or degrade a protein. This decision is not always made correctly, as apparent in neurodegenerative diseases, where misfolded proteins accumulate in diseases neurons. Thus, there is interest in better understanding how cells maintain proteostasis, with the goal of finding ways that balance can be therapeutically restored. For each protein, the decision to “degrade” is typically driven by direct, physical protein-protein interactions (PPIs). For example, chaperone binding is used to discern whether the protein is unfolded. Likewise, PPIs between the protein, chaperones and the ubiquitin conjugation machinery are often used to drive turnover. Our goal is to understand and perturb these PPIs using a chemical biology strategy. Here, we focus on an interesting and relatively under explored category of PPIs: those that occur at N- and C-termini. The chemical environment at the ends of a polypeptide is often unique (e.g. pKa values, dynamics) and these regions can be a hotspot for post-translational modifications (PTMs). Thus, new strategies might be required to chemically manipulate terminal PPIs. Here, we will discuss progress on developing methods towards that goal, including high throughput methods for studying terminal PPIs.

Host: Dr. Marc Mendillo, Assistant Professor, Biochemistry and Molecular Genetics

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Apr

07

BMG Journal Club: Yuki Aoi, PhD and Saeid Mohammad Parast, PhD

Chicago - 1:00 PM - 2:00 PM

Presenters:

Yuki Aoi, PhD, Postdoctoral Fellow, Biochemistry and Molecular Genetics, Shilatifard Lab

Saeid Mohammad Parast, PhD, Postdoctoral Fellow, Biochemistry and Molecular Genetics, Shilatifard Lab

The BMG Journal Club is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience.

Refreshments will be provided.

 

 

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Apr

13

BMG Seminar: Joseph Takahashi, PhD, UT Southwestern Medical Center, Dallas, TX

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry & Molecular Genetics presents:

Joseph Takahashi, PhD
Professor and Chair, Department of Neuroscience
Loyd B. Sands Distinguished Chair in Neuroscience
University of Texas Southwestern Medical Center

Host: Dr. Clara Peek, Assistant Professor of Biochemistry and Molecular Genetics

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Apr

20

BMG Seminar: Gary H. Karpen, PhD, University of California, Berkeley

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry & Molecular Genetics presents:

Gary H. Karpen, PhD
Professor, Department of Molecular and Cell Biology
Senior Faculty Scientist, Lawrence Berekley National Lab
University of California Berekley

Presentation:

"New insights into formation, organization and function of heterochromatin condensates"

Abstract: 

The possibility that dynamic biophysical mechanisms, in particular liquid-liquid phase separation (LLPS), regulate formation and function of chromatin domains is exciting, because it can explain previously enigmatic observations about nuclear structure and function.  We previously demonstrated that formation of one important chromatin domain, called heterochromatin, behaves as a condensate in vivo in fruit flies and mammals, and thus is likely initially formed via LLPS.  I will describe recent progress on elucidating the critical components and interactions responsible for heterochromatin condensate formation in vivo. I will then focus on whether condensates and associated properties such as liquidity, are directly required for heterochromatin organization, functions and dynamics. Finally, I will discuss recent progress in understanding the interplay between heterochromatin and nucleoli, two condensates with distinct but linked cellular functions, with respect to their de novo formation and functions in early Drosophila embryos.

Host: Dr. Daniel Foltz, Professor of Biochemistry and Molecular Genetics

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Apr

21

BMG Journal Club: Olivia Vidal-Cruchez, PhD and Pedro A. Avila-Lopez, PhD

Chicago - 1:00 PM - 2:00 PM

Presenters:

Olivia Vidal-Cruchez, PhD, Postdoctoral Fellow, Biochemistry and Molecular Genetics, Ben-Sahra Lab

Pedro A. Avila-Lopez, PhD, Postdoctoral Fellow, Biochemistry and Molecular Genetics, Lauberth Lab

The BMG Journal Club is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience.

Refreshments will be provided.

 

 

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Apr

27

BMG Seminar: Matthew D. Shoulders, PhD, Massachusettes Institute of Technology (MIT), Cambridge, MA

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry & Molecular Genetics presents:

Matthew D. Shoulders, PhD
Professor, Department of Chemistry
Massachusettes Institute of Technology

Host: Dr. Marc Mendillo, Assistant Professor of Biochemistry and Molecular Genetics

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May

04

BMG Seminar: Yin Shen, PhD, University of California San Francisco (UCSF)

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry & Molecular Genetics presents:

Yin Shen, PhD
Associate Professor
Institute for Human Genetics, Department of Neurology
University of California San Francisco (UCSF) 

Presentation:

"Characterize non-coding DNA variants in the human genome"

Abstract:

Advances in genome sequencing have led to the identification of hundreds of millions of genetic variants in the human population, with a fraction conferring risk for common illnesses such as diabetes, neurological disorders, and cancers. A significant barrier to understanding the genetic underpinnings of these complex diseases is the lack of functional annotation for disease-associated sequence variants, primarily because such variants are predominantly located within non-coding regions. However, research on the role of these candidate cis-regulatory elements and variants in disease pathogenesis has been hindered by a lack of knowledge of their biological function in relevant cell types. I will discuss our approaches to functional characterize candidate cis-regulatory elements and demystify how non-coding variants could contribute to human health and disease.

Host: Dr. Feng Yue, Professor of Biochemistry and Molecular Genetics and Pathology

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May

05

BMG Journal Club: Ram Prosad Chakrabarty and Shashank Srivastava, PhD

Chicago - 1:00 PM - 2:00 PM

Presenters:

Shashank Srivastava, PhD, Postdoctoral Fellow, Biochemistry and Molecular Genetics, Foltz Lab

Ram Prosad Chakrabarty, DGP Graduate Student, Biochemistry and Molecular Genetics, Chandel Lab

The BMG Journal Club is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience.

Refreshments will be provided.

 

 

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Feb

08

Fulbright ETA Information Session

Online - 12:00 PM - 1:00 PM

How to apply for a Fulbright English Teaching Assistantship.

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Feb

09

Searle Center Winter Retreat

Evanston - 10:00 AM - 2:30 PM

Graduate students and postdocs with a strong interest in teaching are invited to join the Searle Center for a half-day retreat focused on sparking their own and their students’ curiosity.

Curiosity is a key trait for the successful navigation of new demands during challenging times. Sparking student curiosity is a core goal of many instructors, but how can we do this when we are struggling to engage ourselves? A large body of research from a variety of disciplines highlights the importance of maintaining one’s curiosity, particularly for educators. At the Winter Retreat, participants will examine a variety of ways in which both students and their own curiosity can not only be sparked but nurtured into meaningful learning experiences.

During this event, participants will deeply engage in an interactive session led by Steven Adams, Librarian for Graduate and Postdoctoral Initiatives; workshop teaching materials in small groups with peers, and build community with other graduate students and postdocs invested in teaching. Lunch will be served.

 

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Feb

09

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Feb

10

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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Feb

13

Cancer Research with MRI: Deciphering the Alphabet Soup - Chad R. Haney, PhD

Chicago - 12:00 PM - 1:00 PM

Lurie Cancer Center Core Technologies & Applications Seminar
Sponsored by the Center for Advanced Molecular Imaging

Chad R. Haney, PhD
Research Professor in Chemistry Life Processes Institute
Radiology, and Biomedical Engineering
Managing Director, Center for Advanced Molecular Imaging
Northwestern University Feinberg School of Medicine

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Feb

13

Fulbright ETA Information Session

Online - 12:00 PM - 1:00 PM

How to apply for a Fulbright English Teaching Assistantship.

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Feb

13

Pharmacology Research Works in Progress - Eduardo Guadarrama & Andrew Hoffman

Chicago - 3:00 PM - 4:00 PM

Eduardo Guadarrama
PhD Candidate in the Laboratory of Paul DeCaen, PhD

Andrew Hoffman 
Postdoctoral Scholar in the Laboratory of Huiping Liu, PhD, MD

 

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Feb

14

M-I Dept. Seminar Series / Transcriptional Regulation Through Reorganization of Host Chromatin by Human Cytomegalovirus

Chicago - 12:00 PM - 1:00 PM

Title:

Transcriptional Regulation Through Reorganization of Host Chromatin by Human Cytomegalovirus

Speaker:

Celeste Rosencrance, DGP Progam Graduate Student, Lab of Dr. Derek Walsh

Topic:

Investigation of structure-function relationships drive discovery in all aspects of biology; however, the link between nuclear shape and cellular processes in this adaptable, membrane-bound organelle is not well understood. The genetic information that controls cell function is contained and organized within the nucleus, thus changes in nuclear morphology may affect cell behavior. The nucleus can be shaped by disease, viral infection, and cell migration, yet how these nuclear deformations contribute to transcriptional changes remains a crucial area of research. Human Cytomegalovirus (HCMV) exerts cytoplasmic control on the host nucleus in mid-to-late stages of infection that results in nuclear rotation, polarization of nuclear membrane proteins and repressive chromatin, as well as spatial arrangement of both viral and host genomic material. While polarization may allow viral DNA to replicate in a permissive nuclear compartment, the effect of host DNA polarity and subsequent transcriptional regulation represents an underappreciated feature of HCMV control over host processes. My research focuses on the relationship between HCMV-induced nuclear polarization, altered chromatin structure, and host transcription to support viral infection and spread.

Host: Derek Walsh, Professor, Dept. of Microbiology-Immunology

 

 

 



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Feb

15

CDB Faculty Seminar Presents: Karen Ridge, PhD

Chicago - 12:00 PM - 1:00 PM

CDB Faculty Seminars Presents:

“A missing piece of the puzzle in pulmonary fibrosis: vimentin activates inflammatory signaling pathways"

Karen Ridge, Ph.D.
Ernest S. Bazley Professor of Pulmonary Sciences
Departments of Medicine (Pulmonary and Critical Care) and 
Cell & Developmental Biology

Wednesday, February 15th, 2023
12:00–1:00 PM

Simpson Querrey Auditorium, SQ 1-230

For more information please contact cdb@northwestern.edu
Click here to subscribe to the CDB Seminar Series listserv.

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Feb

16

CDB Faculty Recruitment Event

No Location - 10:30 AM - 11:30 AM

Event is limited to CDB and Northwestern Community

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Feb

16

Fulbright Information Meeting for Study/Research & Arts awards

Online - 12:00 PM - 1:00 PM

Interested in Fulbright Study/Research & Arts Awards? Attend this meeting to learn how Fulbright can transform your life and pursuits.  You will hear about the history of the Fulbright program, understand the core values that animate the Fulbright competition, review various kinds of awards and understand the Northwestern University application process and timeline. Get all your Fulbright questions answered!

 

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Feb

16

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Feb

17

Writing Your Teaching Statement: Tailoring to Specific Contexts

Online - 12:00 PM - 1:30 PM

Drafting a Teaching Statement can be a challenging process, particularly for graduate students and postdoctoral fellows who may have limited teaching experience.

In this workshop, participants will learn about some of the commonly recommended characteristics of teaching statements and practice how to modify an existing teaching statement draft or outline to suit the needs of various specific contexts, such as different institutional settings or working across disciplines.

Participants will leave the workshop with an understanding of where and how they can make small changes to their statements that will meet the requirements of a job or grant application.

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Feb

17

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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Feb

20

Fulbright ETA Information Session

Evanston - 12:00 PM - 1:00 PM

How to apply for a Fulbright English Teaching Assistantship.

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Feb

20

Pharmacology Research Works in Progress - Raikundalia Sweta, PhD & Állan Ferrari, PhD

Chicago - 3:00 PM - 4:00 PM

Raikundalia Sweta, PhD
Postdoctoral Scholar in the Laboratory of Daniel Arango, PhD

Állan Ferrari, PhD
Postdoctoral Scholar in the Laboratory of Gabriel Rocklin, PhD

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Feb

21

Fulbright Information Meeting for Study/Research & Arts awards

Evanston - 12:00 PM - 1:00 PM

Interested in Fulbright Study/Research & Arts Awards? Attend this meeting to learn how Fulbright can transform your life and pursuits.  You will hear about the history of the Fulbright program, understand the core values that animate the Fulbright competition, review various kinds of awards and understand the Northwestern University application process and timeline. Get all your Fulbright questions answered!

 

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Feb

21

M-I Dept. Seminar Series / Exit Strategies: Egress of Herpesviruses from the Nucleus and Beyond

Chicago - 12:00 PM - 1:00 PM

Title:

Exit Strategies: Egress of Herpesviruses from the Nucleus and Beyond

Speaker:  

Richard Roller, PhD,
Professor
Department of Microbiology and Immunology
University of Iowa

Topic:

Herpesviruses are stunningly successful pathogens, with most humans infected with at least two or three different species.  These viruses establish life-long latent infections and periodically reactivate and then spread within and between hosts.  In reactivation, the virus spreads despite the development of a potent adaptive immune response.  Its ability to do so depends in part on the virus pathways for egress from infected cells.  This seminar will focus on the function of pathways that promote both virus egress and spread between epithelial cells.

 

Host: Gregory A. Smith, Professor, Dept. of Microbiology-Immunology

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Feb

21

Shrove Tuesday British Scholarships Tea

Online - 4:00 PM - 5:00 PM

Join Wildcat winners of British Scholarships to discuss their application adventures!

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Feb

22

CDB Trainee Seminar Series Presents: Yanique Thomas, PhD, and Rebecca Southern

Chicago - 3:30 PM - 5:30 PM

CDB Trainee Seminars Presents:

“Title TBD"

Yanique Thomas, Ph.D.
Postdoctoral Fellow, Hope Lab
3:30-4:00pm

“Title TBD"

Rebecca Southern
Graduate Student, Shukla Lab
4:00-4:30pm

Refreshments to follow.
4:30-5:30pm

Wednesday, February 22nd, 2023
*NEW TIME* 3:30-5:30 PM

Simpson Querrey Auditorium, SQ 1-230

For more information please contact cdb@northwestern.edu
Click here to subcribe to the CDB Seminar Series listserv.

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Feb

23

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Feb

24

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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Feb

27

What's On Your Mind with ChatGPT?

Online - 2:00 PM - 3:00 PM

Join educational developers from the Searle Center and Northwestern colleagues for this knowledge-sharing conversation about the possibilities of learning and teaching with ChatGPT. 

Share how you have used or are planning to use ChatGPT and other AI tools in your courses or get ideas of what you might do. Share your concerns and challenges. Explore some of the bigger questions about the future of AI tools in higher education, such as how these tools may advance diversity, equity, and inclusion goals and how these tools could help or hinder students’ achievement of complex learning objectives related to critical thinking and creativity.

The Searle Center is hosting two online sessions:

1. Monday, February 27, 2023 from 2:00-3:00 PM
2. Tuesday, February 28, 2023 from 9:30-10:30 AM

Each session will be tailored to the experiences, questions, and interests of the participants based on your responses to the RSVP form. 

If you have any questions, contact Lauri Dietz (lauridietz@northwestern.edu)

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Feb

27

Pharmacology Research Works in Progress - Bose Banabithi, PhD & Kirill Korshunov, PhD

Chicago - 3:00 PM - 4:00 PM

Bose Banabithi, PhD
Postdoctoral Scholar in the Laboratory of Barbara Stranger, PhD

Kirill Korshunov, PhD
Postdoctoral Scholar in the Laboratory of Murali Prakryia, PhD

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Feb

28

What's On Your Mind with ChatGPT?

Online - 9:30 AM - 10:30 AM

Join educational developers from the Searle Center and Northwestern colleagues for this knowledge-sharing conversation about the possibilities of learning and teaching with ChatGPT. 

Share how you have used or are planning to use ChatGPT and other AI tools in your courses or get ideas of what you might do. Share your concerns and challenges. Explore some of the bigger questions about the future of AI tools in higher education, such as how these tools may advance diversity, equity, and inclusion goals and how these tools could help or hinder students’ achievement of complex learning objectives related to critical thinking and creativity.

The Searle Center is hosting two online sessions:

1. Monday, February 27, 2023 from 2:00-3:00 PM
2. Tuesday, February 28, 2023 from 9:30-10:30 AM

Each session will be tailored to the experiences, questions, and interests of the participants based on your responses to the RSVP form. 

If you have any questions, contact Lauri Dietz (lauridietz@northwestern.edu)

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Feb

28

M-I Seminar Series / Role of TIM Family of Genes in Regulating Anti-Tumor Immunity

Chicago - 12:00 PM - 1:00 PM

Title: 

Role of TIM Family of Genes in Regulating Anti-Tumor Immunity

Speaker:

Vijay Kuchroo, Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston

 

Topic: 

 

T cell Immunoglobulin and Mucin containing molecules 3 (Tim-3), first identified as a molecule expressed on IFN-g producing T cells, is emerging as an important immune-checkpoint molecule whose therapeutic blockade is currently being investigated in multiple human malignancies. While expression of Tim-3 on CD8+ T cells in the tumor microenvironment is considered a cardinal sign of terminal T cell dysfunction, Tim-3 is also expressed on several other immune cells, confounding the interpretation of immunological and clinical results following blockade using anti-Tim-3 monoclonal antibodies.  Using conditional knockouts of Tim-3 together with single-cell RNA-seq, we demonstrate the singular importance of Tim-3 expression in dendritic cells (DCs), whereby loss of Tim-3 on DCs, promotes strong anti-tumor immunity by regulating Inflammasome activation. Another family member Tim-1 has been found to be expressed on a subset of B cells that expand during tumor growth. Selective deletion of Havcr1 (the gene encoding TIM-1) in B cells both dramatically inhibited tumor growth and enhanced effector T cell responses.  Our results demonstrate that besides T cells, TIM -family of proteins may be checkpoint molecules on other cell types as well and manipulation of the Tim-3 and Tim-1 enables the engagement of DCs and B cells to promote anti-tumor immunity and inhibit tumor growth.”

 

Host:

Pablo Penaloza-MacMaster, PhD, Assistant Professor, Dept. Of Microbiology-Immunology

 

 

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Mar

01

CDB Faculty Meeting

No Location - 12:00 PM - 1:00 PM

Cell & Developmental Biology Department Faculty Meeting

Meeting details disseminated via listserv. If you believe you missed an announcement, please email us at cdb@northwestern.edu.

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Mar

01

Fulbright ETA Information Session [copy]

Evanston - 12:00 PM - 1:00 PM

How to apply for a Fulbright English Teaching Assistantship.

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Mar

02

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Mar

03

Writing Your Teaching Statement: Peer Review

Online - 10:00 AM - 12:00 PM

Teaching statements are an important component of many academic job applications, but they can be challenging to write. Receiving feedback from peers can provide you with recommendations on how to clarify and improve your main claims about your teaching. Allowing others to read your writing can also give you critical insight into how your target audience may understand and interpret your claims, which can help further refine your teaching statement.

In this highly interactive workshop, participants will share their teaching statement drafts and engage in guided peer feedback. Please bring a draft of your teaching statement to the workshop to share.

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Mar

03

Neuroscience Seminar Series: Steven Graves Ph.D

Chicago - 12:00 PM - 1:00 PM

Expertise
 

Slice electrophysiology, stereology, immunohistochemistry, two-photon laser scanning microscopy, and behavioral pharmacology

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Mar

03

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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Mar

06

Pharmacology Seminar Series - Richard Miller, PhD

Chicago - 3:00 PM - 4:00 PM

Richard Miller, PhD 
Professor Emeritus, Department of Pharmacology
Northwestern Pharmacology 

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Mar

07

Fulbright Information Meeting for Study/Research & Arts awards

Evanston - 9:00 AM - 10:00 AM

Interested in Fulbright Study/Research & Arts Awards? Attend this meeting to learn how Fulbright can transform your life and pursuits.  You will hear about the history of the Fulbright program, understand the core values that animate the Fulbright competition, review various kinds of awards, and hear about the Northwestern University application process and timeline. Get all your Fulbright questions answered!

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Mar

07

Fulbright ETA Information Session

Evanston - 12:00 PM - 1:00 PM

How to apply for a Fulbright English Teaching Assistantship.

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Mar

08

CDB Seminar Series Presents: Ian Cheeseman, Ph.D., Massachusetts Institute of Technology, Cambridge, MA

Chicago - 12:00 PM - 1:00 PM

CDB "EXPERTS-IN-THE-FIELD" SEMINAR PRESENTATION: 

"Title TBD"

Ian Cheeseman, Ph.D.
Herman and Margaret Sokol Professor of Biology
Core Member, Whitehead Institute
Massachusetts Institute of Technology
Cambridge, Massachusetts

Wednesday, March 8, 2023
12:00–1:00 PM

Simpson Querrey Auditorium, SQ 1-230

Host: Dr. Dileep Varma
Assistant Professor
Department of Cell and Developmental Biology

For more information, please contact cdb@northwestern.edu
To subscribe to the CDB Seminar Series listserv, please visit
https://www.feinberg.northwestern.edu/sites/cdb/about/contact-us/index.html

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Mar

09

Spring Quarter Academic Kickoff Event

Evanston - 9:00 AM - 4:30 PM

The Quarterly Academic Kickoff events provide first-time TAs and grad student and postdoc instructors opportunities to learn about and explore institutional knowledge to get their head in the game for the first day of classes! Participants are invited to attend a variety of interactive sessions throughout the day facilitated by campus partners and experienced graduate student instructors known as Team Captains. Each session is grounded in evidence-based practices and Northwestern’s Principles of Inclusive Teaching. Participants will also have plenty of opportunities to informally socialize during morning coffee, intentional breaks, and a lunch hour.  

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Mar

09

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Mar

09

Scott Lecture Series: "The chromosomal basis of sex differences in health and disease" with David Page, MD | HYBRID EVENT

Chicago - 3:30 PM - 4:30 PM

The Center for Genetic Medicine Presents:

Scott Lecture Series | "The chromosomal basis of sex differences in health and disease"

With Guest Speaker:
David Page, MD
Member, Whitehead Institute
Professor of Biology
Massachusetts Institute of Technology
Investigator, Howard Hughes Medical Institute

A reception will follow the lecture at 4:30 p.m. in the Ryan Family Atrium (in-person only)

**This seminar is offered as a HYBRID event; join us IN-PERSON or ONLINE. There is no cost to attend, but please register and indicate your intended mode of attendance. 

About Dr. Page:
The Page lab studies the genetic differences between males and females and the biological and medical ramifications of these differences.  At the core are the sex chromosomes: females have two X chromosomes, while males have an X and a Y.  The Page Lab has overturned the long-held view that the influence of sex chromosome constitution (XX vs. XY) is restricted to the reproductive tract.  Intrinsic differences between XX and XY cells exist across the body, likely contributing to the pervasive differences that exist between males and females in the incidence, severity, and progression of diseases that collectively affect all organ systems.  A grand opportunity awaits: To understand male-female differences in disease by understanding male-female differences in healthy cells, tissues, and organs, at a molecular level and across the body.  

About the Lecture Series:
This presentation is part of the Scott Lecture Series and is co-sponsored the Driskill Graduate Program in Life Sciences at Northwestern University. 

The series was created as an educational platform to appeal to the medical community. Funded under the generous bequest of alum Richard A. Scott, MD, his wife and family established the lecture series in honor of his lifelong interest in research and learning after his passing.

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Mar

10

FCVRRI Seminar - Brian Black, PhD

Chicago - 11:30 AM - 12:30 PM

Please join us on March 10 for Dr. Black's lecture on Injury Responsive Endothelial Enhancers Promote Heart Regeneration in Zebrafish.

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Mar

10

Neuroscience Seminar Series: Maxime Assous Ph.D

Chicago - 12:00 PM - 1:00 PM

Interests

Basal ganglia circuits, striatum and related behaviors.

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Mar

10

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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Mar

13

Pharmacology Seminar Series - "Impact of regulatory subunit stoichiometry on BK channel function" Christopher Lingle, PhD

Evanston - 3:00 PM - 4:00 PM

"Impact of regulatory subunit stoichiometry on BK channel function"

 

Christopher Lingle, PhD 
Professor of Anesthesiology & Neuroscience
Center for the Investigation of Membrane Excitability Diseases
Institute of Clinical and Translational Sciences
Washington University in St. Louis

Washington University | ResearchGate | PubMed

 

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Mar

14

Fulbright Information Meeting for Study/Research & Arts awards

Evanston - 4:00 PM - 5:00 PM

Interested in Fulbright Study/Research & Arts Awards? Attend this meeting to learn how Fulbright can transform your life and pursuits.  You will hear about the history of the Fulbright program, understand the core values that animate the Fulbright competition, review various kinds of awards, and hear about the Northwestern University application process and timeline. Get all your Fulbright questions answered!

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Mar

15

CDB Trainee Seminar Series Presents: Thatiane Russo, PhD, Jennifer Sheridan, and Aline Grata

Chicago - 3:30 PM - 5:30 PM

CDB Trainee Seminars Presents:

“Title TBD"

Thatiane Russo, Ph.D.
Postdoctoral Fellow, Hope Lab
3:30-4:00pm

“Title TBD"

Jennifer Sheridan and Aline Grata
Research Technologists, Mitchell Lab
4:00-4:30pm

Refreshments to follow
4:30-5:30pm

*NEW DATE* Wednesday, March 15th, 2023
*NEW TIME* 3:30-5:30 PM

Simpson Querrey Auditorium, SQ 1-230

For more information please contact cdb@northwestern.edu
Click here to subcribe to the CDB Seminar Series listserv.

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Mar

16

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Mar

17

Neuroscience Seminar Series: Edwin Chapman Ph.D

Chicago - 12:00 PM - 1:00 PM

CURRENT RESEARCH:

Membrane Trafficking, Fusion, and Synaptic Transmission

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Mar

17

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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Mar

22

CDB Faculty Seminar: Robert Vassar, PhD

Chicago - 12:00 PM - 1:00 PM

CDB Faculty Seminars Presents:

“Title TBD"

Robert Vassar, Ph.D.
Scientific Director of Behavioral Neurology
Davee Professor of Alzheimer Research
Departments of Neurology (Behavioral Neurology) and
Cell and Developmental Biology

Wednesday, March 22nd, 2023
12:00–1:00 PM

Simpson Querrey Auditorium, SQ 1-230

For more information please contact cdb@northwestern.edu
Click here to subcribe to the CDB Seminar Series listserv.

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Mar

23

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Mar

23

CAN SEMINAR SERIES: Weizhe Hong: "Understanding the Social Brain"

Chicago - 2:00 PM - 3:00 PM

Abstract:

Social interactions between individuals and among groups are a hallmark of human society and are critical to the physical and mental health of a wide variety of species including humans. The central goal of our lab is to study the fundamental principles of how social behavior is regulated in the brain. We are particularly interested in prosocial behavior that animals display to benefit other individuals. We study how neural circuits and the underlying computation regulate social behavioral decisions within a single brain as well as how emergent inter-brain neural properties arise from social interactions between individuals.
JPEG headshot?

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Mar

24

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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Mar

24

Chicago Cytoskeleton Meeting

Chicago - 3:00 PM - 6:00 PM

Chicago Cytoskeleton Meeting in person!

 

March 24  3:00 – 6:00 PM  

Simpson Querrey Auditorium, SQ 1 -230

303 E. Superior Street, Chicago, IL 60611

Northwestern, Feinberg School of Medicine

 

The Chicago Cytoskeleton is a forum for cytoskeletal researchers from the greater Chicago area to meet, hear great talks, exchange ideas, and socialize. For additional information, please visit: https://chicagocytoskeleton.net/

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Mar

27

Pharmacology Seminar Series - Elena Oancea, PhD

Chicago - 3:00 PM - 4:00 PM

Elena Oancea, PhD
Assosiate Professor of Medical Science
Department of Molecular Pharmacology, Physiology and Biotechnology
Brown University

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Mar

29

CDB Trainee Seminar Series Presents: Eve Suva and Bella Han

Chicago - 3:30 PM - 5:30 PM

CDB Trainee Seminars Presents:

“Title TBD"

Eve Suva
Graduate Student, Mitchell Lab
3:30-4:00pm

“Title TBD"

Bella Han
Research Technologist, Shukla Lab
4:00-4:30pm

Refreshments to follow
4:30-5:30pm

Wednesday, March 29th, 2023
*NEW TIME* 3:30-5:30 PM

Simpson Querrey Auditorium, SQ 1-230

For more information please contact cdb@northwestern.edu
Click here to subcribe to the CDB Seminar Series listserv.

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Mar

30

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Mar

31

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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Apr

05

CDB Faculty Meeting

No Location - 12:00 PM - 1:00 PM

Cell & Developmental Biology Department Faculty Meeting

Meeting details disseminated via listserv. If you believe you missed an announcement, please email us at cdb@northwestern.edu.

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Apr

06

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Apr

07

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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Apr

12

CDB Seminar Series Presents: Allon Klein, PhD, Harvard Medical School

Chicago - 12:00 PM - 1:00 PM

CDB "EXPERTS-IN-THE-FIELD" SEMINAR PRESENTATION: 

"Title TBD"

Allon Klein, Ph.D.
Associate Professor
Department of Systems Biology
Harvard Medical School
Boston, Massachusetts

Wednesday, April 12, 2023
12:00–1:00 PM

Simpson Querrey Auditorium, SQ 1-230
303 E. Superior St., Chicago

Host: Dr. Yogesh Goyal, Ph.D.
Assistant Professor
Department of Cell & Developmental Biology
Center for Synthetic Biology

For more information, please contact cdb@northwestern.edu 
To subscribe to the CDB Seminar Series listserv, please visit https://www.feinberg.northwestern.edu/sites/cdb/about/contact-us/index.html

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Apr

13

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Apr

14

Neuroscience Seminar Series: Dietmar Plenz Ph.D

Chicago - 12:00 PM - 1:00 PM

Dr. Plenz is Chief of the Section on Critical Brain Dynamics in the Intramural Research Program at the NIMH.  He attended college at the Universities of Mainz and Tuebingen, Germany. Under the supervision of Prof. Valentino Braitenberg and Ad Aertsen, he received his Ph.D. in 1993 at the Max-Planck Institute of Biological Cybernetics/University Tuebingen, where he pioneered the development of in vitro cortex networks to study the emergence of neuronal population dynamics.  During his 3 year postdoctoral fellowship with Stephen T. Kitai at the University of Tennessee, Memphis, he developed advanced cortex-forebrain neuronal cultures that allowed him to identify the mechanisms of distinct activity patterns that characterize normal and abnormal population dynamics in cortex and basal ganglia. Dr. Plenz joined the NIMH as a Tenure-track Investigator in 1999 and was promoted to Senior Investigator with tenure in 2006.  His laboratory combines electrophysiological and imaging techniques and neural modeling to study the self-organization of neuronal networks.

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Apr

14

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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Apr

17

Pharmacology Seminar Series - Yang Yang, PhD

Chicago - 3:00 PM - 4:00 PM

Yang Yang, PhD
Assistant Professor of Medicinal Chemistry and Molecular Pharmacology
Purdue University

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Apr

19

CDB Faculty Seminar: Erica Davis, Ph.D.

Chicago - 12:00 PM - 1:00 PM

CDB Faculty Seminars Presents:

“Title TBD"

Erica Davis, Ph.D.
Associate Professor
Departments of Pediatrics and
Cell & Developmental Biology

Wednesday, April 19th, 2023
12:00–1:00 PM

Simpson Querrey Auditorium, SQ 1-230

For more information please contact cdb@northwestern.edu
Click here to subcribe to the CDB Seminar Series listserv.

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Apr

20

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Apr

21

Neuroscience Seminar Series: Jeremy Day Ph.D

Chicago - 12:00 PM - 1:00 PM

Research Areas:


Neurogenetics, substance use disorders, learning and memory, epigenetics, gene regulation and gene editing.

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Apr

21

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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Apr

21

Chicago Cytoskeleton Meeting

Chicago - 3:00 PM - 6:00 PM

Chicago Cytoskeleton Meeting in person!

 

April 21  3:00 – 6:00 PM  

Simpson Querrey Auditorium, SQ 1 -230

303 E. Superior Street, Chicago, IL 60611

Northwestern, Feinberg School of Medicine

 

The Chicago Cytoskeleton is a forum for cytoskeletal researchers from the greater Chicago area to meet, hear great talks, exchange ideas, and socialize. For additional information, please visit: https://chicagocytoskeleton.net/

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Apr

26

CDB Trainee Seminar Series Presents: Annmarie Dominguez and Jeanne Quinn

Chicago - 3:30 PM - 5:30 PM

CDB Trainee Seminars Presents:

“Title TBD"

Annmarie Dominguez
Graduate Student, Arispe Lab
3:30-4:00pm

“Title TBD"

Jeanne Quinn
Graduate Student, Gottardi Lab
4:00-4:30pm

Refreshments to follow
4:30-5:30pm

Wednesday, April 26th, 2023
*NEW TIME* 3:30-5:30 PM

Simpson Querrey Auditorium, SQ 1-230

For more information please contact cdb@northwestern.edu
Click here to subcribe to the CDB Seminar Series listserv.

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Apr

27

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Apr

27

CAN SEMINAR SERIES: Dr. Craig Powell

Chicago - 2:00 PM - 3:00 PM

Dr. Craig Powell

Professor
Director, Civitan International Research Center
Chair, Department of Neurobiology
Virginia B. Spencer Endowed Chair
Research Areas
Autism, intellectual disability, cognitive dysfunction

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Apr

28

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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May

01

Department of Pharmacology Seminar - Neville Sanjana, Ph.D.

Chicago - 3:00 PM - 4:00 PM

Neville Sanjana, Ph.D.
Assistant Professor, Department of Biology
Center for Genomics and Systems Biology
New York University

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May

03

CDB Faculty Meeting

No Location - 12:00 PM - 1:00 PM

Cell & Developmental Biology Department Faculty Meeting

Meeting details disseminated via listserv. If you believe you missed an announcement, please email us at cdb@northwestern.edu.

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May

04

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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May

05

Neuroscience Seminar Series: Giandomenico Iannetti Ph.D

Chicago - 12:00 PM - 1:00 PM

We investigate fundamental questions about how humans and other animals cope with the world through perception and action. We are particularly interested in understanding the mechanisms that brains have evolved for the detection and the motor reaction to sudden and surprising environmental stimuli.

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May

05

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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May

08

Pharmacology Seminar Series - Yoseph Barash, PhD

Chicago - 3:00 PM - 4:00 PM

Yoseph Barash, PhD
Assistant Professor of Medicinal Chemistry and Molecular Pharmacology
Purdue University

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May

10

CDB Seminar Series Presents: Harmit Singh Malik, Ph.D., Fred Hutchinson Cancer Research Center, Seattle, WA

Chicago - 12:00 PM - 1:00 PM

CDB "EXPERTS-IN-THE-FIELD" SEMINAR PRESENTATION: 

"Title TBD"

Harmit Singh Malik, Ph.D.
Professor and Associate Director
Division of Basic Sciences
HHMI Investigator
Member, US National Academy of Sciences
Fred Hutchinson Cancer Research Center
Seattle, Washington

Wednesday, May 10, 2023
12:00–1:00 PM

Simpson Querrey Auditorium, SQ 1-230
303 E. Superior St., Chicago

Host: Dr. Vipul Shukla
Assistant Professor
Department of Cell and Developmental Biology

For more information, please contact cdb@northwestern.edu
To subscribe to the CDB Seminar Series listserv, please visit https://www.feinberg.northwestern.edu/sites/cdb/about/contact-us/index.html

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May

11

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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May

12

Neuroscience Seminar Series: Sean Escola Ph.D

Chicago - 12:00 PM - 1:00 PM

Research Interests:

Cognitive/Systems Neuroscience, Computational Psychiatry, Computation and Theory, Motor Systems, Theoretical Neuroscience.

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May

12

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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No events found. Please try again later.

Feb

08

Fulbright ETA Information Session

Online - 12:00 PM - 1:00 PM

How to apply for a Fulbright English Teaching Assistantship.

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Feb

09

BMG Seminar: G.R. Scott Budinger, MD, Northwestern University Feinberg School of Medicine

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry & Molecular Genetics presents:

GR Scott Budinger, MD
Chief of Pulmonary and Critical Care in the Department of Medicine
Ernest S. Bazley Professor of Airway Diseases
Professor of Medicine (Pulmonary and Critical Care) and Cell and Developmental Biology
Northwestern University Feinberg School of Medicine

Presentation: 

“Lessons from the pandemic: Distinctive features of SARS-CoV-2 pneumonia”

 

Host: Dr. Ali Shilatifard, Chairman, Department of Biochemistry and Molecular Genetics

 

 

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Feb

09

Searle Center Winter Retreat

Evanston - 10:00 AM - 2:30 PM

Graduate students and postdocs with a strong interest in teaching are invited to join the Searle Center for a half-day retreat focused on sparking their own and their students’ curiosity.

Curiosity is a key trait for the successful navigation of new demands during challenging times. Sparking student curiosity is a core goal of many instructors, but how can we do this when we are struggling to engage ourselves? A large body of research from a variety of disciplines highlights the importance of maintaining one’s curiosity, particularly for educators. At the Winter Retreat, participants will examine a variety of ways in which both students and their own curiosity can not only be sparked but nurtured into meaningful learning experiences.

During this event, participants will deeply engage in an interactive session led by Steven Adams, Librarian for Graduate and Postdoctoral Initiatives; workshop teaching materials in small groups with peers, and build community with other graduate students and postdocs invested in teaching. Lunch will be served.

 

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Feb

09

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Feb

10

CANCELLED - BMG Journal Club

Chicago - 1:00 PM - 2:00 PM

The BMG Journal Club is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience.

 

 

 

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Feb

10

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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Feb

13

Cancer Research with MRI: Deciphering the Alphabet Soup - Chad R. Haney, PhD

Chicago - 12:00 PM - 1:00 PM

Lurie Cancer Center Core Technologies & Applications Seminar
Sponsored by the Center for Advanced Molecular Imaging

Chad R. Haney, PhD
Research Professor in Chemistry Life Processes Institute
Radiology, and Biomedical Engineering
Managing Director, Center for Advanced Molecular Imaging
Northwestern University Feinberg School of Medicine

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Feb

13

Fulbright ETA Information Session

Online - 12:00 PM - 1:00 PM

How to apply for a Fulbright English Teaching Assistantship.

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Feb

13

Pharmacology Research Works in Progress - Eduardo Guadarrama & Andrew Hoffman

Chicago - 3:00 PM - 4:00 PM

Eduardo Guadarrama
PhD Candidate in the Laboratory of Paul DeCaen, PhD

Andrew Hoffman 
Postdoctoral Scholar in the Laboratory of Huiping Liu, PhD, MD

 

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Feb

14

M-I Dept. Seminar Series / Transcriptional Regulation Through Reorganization of Host Chromatin by Human Cytomegalovirus

Chicago - 12:00 PM - 1:00 PM

Title:

Transcriptional Regulation Through Reorganization of Host Chromatin by Human Cytomegalovirus

Speaker:

Celeste Rosencrance, DGP Progam Graduate Student, Lab of Dr. Derek Walsh

Topic:

Investigation of structure-function relationships drive discovery in all aspects of biology; however, the link between nuclear shape and cellular processes in this adaptable, membrane-bound organelle is not well understood. The genetic information that controls cell function is contained and organized within the nucleus, thus changes in nuclear morphology may affect cell behavior. The nucleus can be shaped by disease, viral infection, and cell migration, yet how these nuclear deformations contribute to transcriptional changes remains a crucial area of research. Human Cytomegalovirus (HCMV) exerts cytoplasmic control on the host nucleus in mid-to-late stages of infection that results in nuclear rotation, polarization of nuclear membrane proteins and repressive chromatin, as well as spatial arrangement of both viral and host genomic material. While polarization may allow viral DNA to replicate in a permissive nuclear compartment, the effect of host DNA polarity and subsequent transcriptional regulation represents an underappreciated feature of HCMV control over host processes. My research focuses on the relationship between HCMV-induced nuclear polarization, altered chromatin structure, and host transcription to support viral infection and spread.

Host: Derek Walsh, Professor, Dept. of Microbiology-Immunology

 

 

 



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Feb

15

CDB Faculty Seminar Presents: Karen Ridge, PhD

Chicago - 12:00 PM - 1:00 PM

CDB Faculty Seminars Presents:

“A missing piece of the puzzle in pulmonary fibrosis: vimentin activates inflammatory signaling pathways"

Karen Ridge, Ph.D.
Ernest S. Bazley Professor of Pulmonary Sciences
Departments of Medicine (Pulmonary and Critical Care) and 
Cell & Developmental Biology

Wednesday, February 15th, 2023
12:00–1:00 PM

Simpson Querrey Auditorium, SQ 1-230

For more information please contact cdb@northwestern.edu
Click here to subscribe to the CDB Seminar Series listserv.

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Feb

16

BMG Seminar: Danwei Huangfu, PhD, Sloan Kettering Institute, New York, NY

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry & Molecular Genetics presents:

Danwei Huangfu, PhD
Member and Professor, Developmental Biology Program
Sloan Kettering Institute

Presentation:

"A stem cell approach to human development, from reconstitution to deconstruction using CRISPR screens"

Abstract: 

The Huangfu lab interrogates human development and disease mechanisms through combining genome editing tools with stem cell technology. They have led the development of efficient genome editing tools in human pluripotent stem cells (hPSCs), and further implemented these tools to interrogate pancreatic development and diabetes mechanisms through the studies of hPSC-derived pancreatic progenitors and islet-like organoids. They have further spearheaded CRISPR-Cas9 genome-scale knockout screening approach to identify novel genetic regulators of hPSC differentiation, an approach they have extended to the discovery of regulators of DNA methylation.

Host: Dr. Feng Yue, Professor of Biochemistry and Molecular Genetics and Pathology

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Feb

16

CDB Faculty Recruitment Event

No Location - 10:30 AM - 11:30 AM

Event is limited to CDB and Northwestern Community

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Feb

16

Fulbright Information Meeting for Study/Research & Arts awards

Online - 12:00 PM - 1:00 PM

Interested in Fulbright Study/Research & Arts Awards? Attend this meeting to learn how Fulbright can transform your life and pursuits.  You will hear about the history of the Fulbright program, understand the core values that animate the Fulbright competition, review various kinds of awards and understand the Northwestern University application process and timeline. Get all your Fulbright questions answered!

 

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Feb

16

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Feb

17

Writing Your Teaching Statement: Tailoring to Specific Contexts

Online - 12:00 PM - 1:30 PM

Drafting a Teaching Statement can be a challenging process, particularly for graduate students and postdoctoral fellows who may have limited teaching experience.

In this workshop, participants will learn about some of the commonly recommended characteristics of teaching statements and practice how to modify an existing teaching statement draft or outline to suit the needs of various specific contexts, such as different institutional settings or working across disciplines.

Participants will leave the workshop with an understanding of where and how they can make small changes to their statements that will meet the requirements of a job or grant application.

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Feb

17

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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Feb

20

Fulbright ETA Information Session

Evanston - 12:00 PM - 1:00 PM

How to apply for a Fulbright English Teaching Assistantship.

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Feb

20

Pharmacology Research Works in Progress - Raikundalia Sweta, PhD & Állan Ferrari, PhD

Chicago - 3:00 PM - 4:00 PM

Raikundalia Sweta, PhD
Postdoctoral Scholar in the Laboratory of Daniel Arango, PhD

Állan Ferrari, PhD
Postdoctoral Scholar in the Laboratory of Gabriel Rocklin, PhD

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Feb

21

Fulbright Information Meeting for Study/Research & Arts awards

Evanston - 12:00 PM - 1:00 PM

Interested in Fulbright Study/Research & Arts Awards? Attend this meeting to learn how Fulbright can transform your life and pursuits.  You will hear about the history of the Fulbright program, understand the core values that animate the Fulbright competition, review various kinds of awards and understand the Northwestern University application process and timeline. Get all your Fulbright questions answered!

 

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Feb

21

M-I Dept. Seminar Series / Exit Strategies: Egress of Herpesviruses from the Nucleus and Beyond

Chicago - 12:00 PM - 1:00 PM

Title:

Exit Strategies: Egress of Herpesviruses from the Nucleus and Beyond

Speaker:  

Richard Roller, PhD,
Professor
Department of Microbiology and Immunology
University of Iowa

Topic:

Herpesviruses are stunningly successful pathogens, with most humans infected with at least two or three different species.  These viruses establish life-long latent infections and periodically reactivate and then spread within and between hosts.  In reactivation, the virus spreads despite the development of a potent adaptive immune response.  Its ability to do so depends in part on the virus pathways for egress from infected cells.  This seminar will focus on the function of pathways that promote both virus egress and spread between epithelial cells.

 

Host: Gregory A. Smith, Professor, Dept. of Microbiology-Immunology

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Feb

21

Shrove Tuesday British Scholarships Tea

Online - 4:00 PM - 5:00 PM

Join Wildcat winners of British Scholarships to discuss their application adventures!

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Feb

22

CDB Trainee Seminar Series Presents: Yanique Thomas, PhD, and Rebecca Southern

Chicago - 3:30 PM - 5:30 PM

CDB Trainee Seminars Presents:

“Title TBD"

Yanique Thomas, Ph.D.
Postdoctoral Fellow, Hope Lab
3:30-4:00pm

“Title TBD"

Rebecca Southern
Graduate Student, Shukla Lab
4:00-4:30pm

Refreshments to follow.
4:30-5:30pm

Wednesday, February 22nd, 2023
*NEW TIME* 3:30-5:30 PM

Simpson Querrey Auditorium, SQ 1-230

For more information please contact cdb@northwestern.edu
Click here to subcribe to the CDB Seminar Series listserv.

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Feb

23

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Feb

24

BMG Journal Club: Iris Liu, MS and Aileen Szczepanski

Chicago - 1:00 PM - 2:00 PM

Presenters:

Aileen Szczepanski, Research Technologist II, Biochemistry and Molecular Genetics, Wang Lab

and

Iris Liu, MS, DGP Graduate Student, Medicine (Pulmonary and Criticl Care), Singer Lab

Presentation: "SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry"

https://pubmed.ncbi.nlm.nih.gov/36198800/

The BMG Journal Club is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience.

Refreshments will be provided.

 

 

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Feb

24

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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Feb

27

What's On Your Mind with ChatGPT?

Online - 2:00 PM - 3:00 PM

Join educational developers from the Searle Center and Northwestern colleagues for this knowledge-sharing conversation about the possibilities of learning and teaching with ChatGPT. 

Share how you have used or are planning to use ChatGPT and other AI tools in your courses or get ideas of what you might do. Share your concerns and challenges. Explore some of the bigger questions about the future of AI tools in higher education, such as how these tools may advance diversity, equity, and inclusion goals and how these tools could help or hinder students’ achievement of complex learning objectives related to critical thinking and creativity.

The Searle Center is hosting two online sessions:

1. Monday, February 27, 2023 from 2:00-3:00 PM
2. Tuesday, February 28, 2023 from 9:30-10:30 AM

Each session will be tailored to the experiences, questions, and interests of the participants based on your responses to the RSVP form. 

If you have any questions, contact Lauri Dietz (lauridietz@northwestern.edu)

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Feb

27

Pharmacology Research Works in Progress - Bose Banabithi, PhD & Kirill Korshunov, PhD

Chicago - 3:00 PM - 4:00 PM

Bose Banabithi, PhD
Postdoctoral Scholar in the Laboratory of Barbara Stranger, PhD

Kirill Korshunov, PhD
Postdoctoral Scholar in the Laboratory of Murali Prakryia, PhD

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Feb

28

What's On Your Mind with ChatGPT?

Online - 9:30 AM - 10:30 AM

Join educational developers from the Searle Center and Northwestern colleagues for this knowledge-sharing conversation about the possibilities of learning and teaching with ChatGPT. 

Share how you have used or are planning to use ChatGPT and other AI tools in your courses or get ideas of what you might do. Share your concerns and challenges. Explore some of the bigger questions about the future of AI tools in higher education, such as how these tools may advance diversity, equity, and inclusion goals and how these tools could help or hinder students’ achievement of complex learning objectives related to critical thinking and creativity.

The Searle Center is hosting two online sessions:

1. Monday, February 27, 2023 from 2:00-3:00 PM
2. Tuesday, February 28, 2023 from 9:30-10:30 AM

Each session will be tailored to the experiences, questions, and interests of the participants based on your responses to the RSVP form. 

If you have any questions, contact Lauri Dietz (lauridietz@northwestern.edu)

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Feb

28

M-I Seminar Series / Role of TIM Family of Genes in Regulating Anti-Tumor Immunity

Chicago - 12:00 PM - 1:00 PM

Title: 

Role of TIM Family of Genes in Regulating Anti-Tumor Immunity

Speaker:

Vijay Kuchroo, Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston

 

Topic: 

 

T cell Immunoglobulin and Mucin containing molecules 3 (Tim-3), first identified as a molecule expressed on IFN-g producing T cells, is emerging as an important immune-checkpoint molecule whose therapeutic blockade is currently being investigated in multiple human malignancies. While expression of Tim-3 on CD8+ T cells in the tumor microenvironment is considered a cardinal sign of terminal T cell dysfunction, Tim-3 is also expressed on several other immune cells, confounding the interpretation of immunological and clinical results following blockade using anti-Tim-3 monoclonal antibodies.  Using conditional knockouts of Tim-3 together with single-cell RNA-seq, we demonstrate the singular importance of Tim-3 expression in dendritic cells (DCs), whereby loss of Tim-3 on DCs, promotes strong anti-tumor immunity by regulating Inflammasome activation. Another family member Tim-1 has been found to be expressed on a subset of B cells that expand during tumor growth. Selective deletion of Havcr1 (the gene encoding TIM-1) in B cells both dramatically inhibited tumor growth and enhanced effector T cell responses.  Our results demonstrate that besides T cells, TIM -family of proteins may be checkpoint molecules on other cell types as well and manipulation of the Tim-3 and Tim-1 enables the engagement of DCs and B cells to promote anti-tumor immunity and inhibit tumor growth.”

 

Host:

Pablo Penaloza-MacMaster, PhD, Assistant Professor, Dept. Of Microbiology-Immunology

 

 

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Mar

01

CDB Faculty Meeting

No Location - 12:00 PM - 1:00 PM

Cell & Developmental Biology Department Faculty Meeting

Meeting details disseminated via listserv. If you believe you missed an announcement, please email us at cdb@northwestern.edu.

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Mar

01

Fulbright ETA Information Session [copy]

Evanston - 12:00 PM - 1:00 PM

How to apply for a Fulbright English Teaching Assistantship.

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Mar

02

BMG Seminar: James A. Olzmann, PhD, University of California, Berkeley

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry & Molecular Genetics presents:

James A. Olzmann
Associate Professor
Departments of Molecular & Cell Biology and Nutritional Sciences & Toxicology
University of California, Berkeley 

Presentation:

"Mechanisms of lipid quality control and ferroptosis"
 

Hosts: Dr. Issam Ben-Sahra, Assistant Professor of Biochemistry and Molecular Genetics and Dr. Naveep S. Chandel, Professor of Medicine (Pulmonary and Critical Care) and Biochemistry and Molecular Genetics

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Mar

02

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Mar

03

Writing Your Teaching Statement: Peer Review

Online - 10:00 AM - 12:00 PM

Teaching statements are an important component of many academic job applications, but they can be challenging to write. Receiving feedback from peers can provide you with recommendations on how to clarify and improve your main claims about your teaching. Allowing others to read your writing can also give you critical insight into how your target audience may understand and interpret your claims, which can help further refine your teaching statement.

In this highly interactive workshop, participants will share their teaching statement drafts and engage in guided peer feedback. Please bring a draft of your teaching statement to the workshop to share.

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Mar

03

Neuroscience Seminar Series: Steven Graves Ph.D

Chicago - 12:00 PM - 1:00 PM

Expertise
 

Slice electrophysiology, stereology, immunohistochemistry, two-photon laser scanning microscopy, and behavioral pharmacology

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Mar

03

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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Mar

06

Pharmacology Seminar Series - Richard Miller, PhD

Chicago - 3:00 PM - 4:00 PM

Richard Miller, PhD 
Professor Emeritus, Department of Pharmacology
Northwestern Pharmacology 

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Mar

07

Fulbright Information Meeting for Study/Research & Arts awards

Evanston - 9:00 AM - 10:00 AM

Interested in Fulbright Study/Research & Arts Awards? Attend this meeting to learn how Fulbright can transform your life and pursuits.  You will hear about the history of the Fulbright program, understand the core values that animate the Fulbright competition, review various kinds of awards, and hear about the Northwestern University application process and timeline. Get all your Fulbright questions answered!

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Mar

07

Fulbright ETA Information Session

Evanston - 12:00 PM - 1:00 PM

How to apply for a Fulbright English Teaching Assistantship.

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Mar

08

CDB Seminar Series Presents: Ian Cheeseman, Ph.D., Massachusetts Institute of Technology, Cambridge, MA

Chicago - 12:00 PM - 1:00 PM

CDB "EXPERTS-IN-THE-FIELD" SEMINAR PRESENTATION: 

"Title TBD"

Ian Cheeseman, Ph.D.
Herman and Margaret Sokol Professor of Biology
Core Member, Whitehead Institute
Massachusetts Institute of Technology
Cambridge, Massachusetts

Wednesday, March 8, 2023
12:00–1:00 PM

Simpson Querrey Auditorium, SQ 1-230

Host: Dr. Dileep Varma
Assistant Professor
Department of Cell and Developmental Biology

For more information, please contact cdb@northwestern.edu
To subscribe to the CDB Seminar Series listserv, please visit
https://www.feinberg.northwestern.edu/sites/cdb/about/contact-us/index.html

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Mar

09

Spring Quarter Academic Kickoff Event

Evanston - 9:00 AM - 4:30 PM

The Quarterly Academic Kickoff events provide first-time TAs and grad student and postdoc instructors opportunities to learn about and explore institutional knowledge to get their head in the game for the first day of classes! Participants are invited to attend a variety of interactive sessions throughout the day facilitated by campus partners and experienced graduate student instructors known as Team Captains. Each session is grounded in evidence-based practices and Northwestern’s Principles of Inclusive Teaching. Participants will also have plenty of opportunities to informally socialize during morning coffee, intentional breaks, and a lunch hour.  

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Mar

09

BMG Seminar: Kapil Bhalla, MD, University of Texas MD Anderson Cancer Center, Houston, TX

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry and Molecular Genetics presents:

Kapil Bhalla, MD
Professor, Department of Leukemia, Division of Cancer Medicine and Kelcie Kana Research Chair
University of Texas, MD Anderson Cancer Center

Presentation:

"Improving efficacy and overcoming resistance to Menin inhibitor therapy in AML with MLL1r or NPM1 mutation"

Abstract: In MLL1 rearranged (MLL1r) AML (~10%), N-terminus of MLL1 gene is fused to the C-terminus of a fusion partner, e.g. AF9, AF4, ENL and ELL, creating MLL1 fusion protein (MLL-FP), which increases expression of leukemogenic HOXA9 and its co-factor MEIS1. In AML with mutant (mt) NPM1 (NPM1c), MLL1 is the main driver of HOXA9, MEIS1 and FLT3, promoting self-renewal and growth of AML stem-progenitor cells (LSCs). Treatment with Menin inhibitor (MI), SNDX-50469 or SNDX-5613, disrupts binding of Menin to its binding pocket in MLL1/2 and MLL1-FP, reducing expressions of their targets and inducing differentiation and apoptosis. In the phase I/II AUGMENT-101 clinical trial, SNDX-5613 monotherapy was well tolerated and achieved objective remissions in patients with previously treated relapsed/refractory AML harboring MLL1r or NPM1c. However, majority of patients either fail to respond or eventually relapse. A minority of MLL1r AML (~9%) also exhibit a co-mutation in TP53, which is known to confer therapy resistance and poor outcome in AML. This creates the need to develop MI-based synergistic combinations with superior efficacy against patient-derived (PD) AML cells harboring MLL-FP or NPM1c. In present studies, utilizing, CyTOF analysis of PD MLL1-r and NPM1c AML cells following MI showed decline in protein levels of Menin, MEIS1, MEF2C, PBX3, FLT3, CDK6 and BCL2 in phenotypically characterized AML LSCs expressing CLEC12A, CD123, CD244 and CD99. Notably, in vitro co-treatment with SNDX-50469 in combination with venetoclax, pan-BET inhibitor or abemaciclib (CDK6 inhibitor) induced synergistic loss of viability in AML cell lines and in PD AML cells with MLL-r or NPM1c, as well as in MOLM13 cells with CRISPR-Cas9-mediated knock-in of mutant or allelic loss of TP53, but not in normal CD34+ progenitor cells or AML cells lacking MLL-FP or NPM1c. A CRISPR screen with a validated, domain-specific gRNA library against chromatin regulators revealed BRD4, p300, MOZ and KDM1A as druggable co-dependencies with treatment with MI. Consistent with this, co-treatment with SNDX-50469 and OTX015, or the p300/CBP inhibitor GNE049 was synergistically lethal in vitro in AML cells with MLL1r or NPM1c, either sensitive to MI or tolerant-resistant (induced in vitro) to MI (MITR cells). Co-treatment with SNDX-5613 and venetoclax or OTX015 compared to each drug or vehicle control, administered orally for 3 to 4 weeks to NSG mice engrafted with either MOLM13-GFP/Luciferase xenograft or with PD NPM1c and mtFLT3 AML xenograft, caused significantly greater reduction in AML burden and increased overall survival without weight loss or other toxicities. These preclinical findings highlight novel MI-based combinations exhibiting superior in vitro and in vivo anti-AML efficacy against AML cells harboring MLL1-FP or NPM1c that are sensitive or resistance to MI. 

Host: Dr. Lu Wang, Assistant Professor, Biochemistry and Molecular Genetics

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Mar

09

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Mar

09

Scott Lecture Series: "The chromosomal basis of sex differences in health and disease" with David Page, MD | HYBRID EVENT

Chicago - 3:30 PM - 4:30 PM

The Center for Genetic Medicine Presents:

Scott Lecture Series | "The chromosomal basis of sex differences in health and disease"

With Guest Speaker:
David Page, MD
Member, Whitehead Institute
Professor of Biology
Massachusetts Institute of Technology
Investigator, Howard Hughes Medical Institute

A reception will follow the lecture at 4:30 p.m. in the Ryan Family Atrium (in-person only)

**This seminar is offered as a HYBRID event; join us IN-PERSON or ONLINE. There is no cost to attend, but please register and indicate your intended mode of attendance. 

About Dr. Page:
The Page lab studies the genetic differences between males and females and the biological and medical ramifications of these differences.  At the core are the sex chromosomes: females have two X chromosomes, while males have an X and a Y.  The Page Lab has overturned the long-held view that the influence of sex chromosome constitution (XX vs. XY) is restricted to the reproductive tract.  Intrinsic differences between XX and XY cells exist across the body, likely contributing to the pervasive differences that exist between males and females in the incidence, severity, and progression of diseases that collectively affect all organ systems.  A grand opportunity awaits: To understand male-female differences in disease by understanding male-female differences in healthy cells, tissues, and organs, at a molecular level and across the body.  

About the Lecture Series:
This presentation is part of the Scott Lecture Series and is co-sponsored the Driskill Graduate Program in Life Sciences at Northwestern University. 

The series was created as an educational platform to appeal to the medical community. Funded under the generous bequest of alum Richard A. Scott, MD, his wife and family established the lecture series in honor of his lifelong interest in research and learning after his passing.

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Mar

10

FCVRRI Seminar - Brian Black, PhD

Chicago - 11:30 AM - 12:30 PM

Please join us on March 10 for Dr. Black's lecture on Injury Responsive Endothelial Enhancers Promote Heart Regeneration in Zebrafish.

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Mar

10

Neuroscience Seminar Series: Maxime Assous Ph.D

Chicago - 12:00 PM - 1:00 PM

Interests

Basal ganglia circuits, striatum and related behaviors.

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Mar

10

BMG Journal Club: Ye Hou, PhD and Mushtaq Ahmad Nengroo, PhD

Chicago - 1:00 PM - 2:00 PM

Presenters:

Mushtaq Ahmad Nengroo, PhD, Postdoctoral Fellow, Biochemistry and Molecular Genetics, Ben-Sahra Lab

Ye Hou, PhD, Postdoctoral Fellow, Biochemistry and Molecular Genetics, Yue Lab

The BMG Journal Club is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience.

Refreshments will be provided.

 

 

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Mar

10

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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Mar

13

Pharmacology Seminar Series - "Impact of regulatory subunit stoichiometry on BK channel function" Christopher Lingle, PhD

Evanston - 3:00 PM - 4:00 PM

"Impact of regulatory subunit stoichiometry on BK channel function"

 

Christopher Lingle, PhD 
Professor of Anesthesiology & Neuroscience
Center for the Investigation of Membrane Excitability Diseases
Institute of Clinical and Translational Sciences
Washington University in St. Louis

Washington University | ResearchGate | PubMed

 

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Mar

14

Fulbright Information Meeting for Study/Research & Arts awards

Evanston - 4:00 PM - 5:00 PM

Interested in Fulbright Study/Research & Arts Awards? Attend this meeting to learn how Fulbright can transform your life and pursuits.  You will hear about the history of the Fulbright program, understand the core values that animate the Fulbright competition, review various kinds of awards, and hear about the Northwestern University application process and timeline. Get all your Fulbright questions answered!

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Mar

15

CDB Trainee Seminar Series Presents: Thatiane Russo, PhD, Jennifer Sheridan, and Aline Grata

Chicago - 3:30 PM - 5:30 PM

CDB Trainee Seminars Presents:

“Title TBD"

Thatiane Russo, Ph.D.
Postdoctoral Fellow, Hope Lab
3:30-4:00pm

“Title TBD"

Jennifer Sheridan and Aline Grata
Research Technologists, Mitchell Lab
4:00-4:30pm

Refreshments to follow
4:30-5:30pm

*NEW DATE* Wednesday, March 15th, 2023
*NEW TIME* 3:30-5:30 PM

Simpson Querrey Auditorium, SQ 1-230

For more information please contact cdb@northwestern.edu
Click here to subcribe to the CDB Seminar Series listserv.

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Mar

16

BMG Seminar: Gerta Hoxhaj, PhD, UT Southwestern Medical Center, Dallas, TX

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry & Molecular Genetics presents:

Gerta Hoxhaj, Ph.D.
Assistant Professor 
Children’s Research Institute and Department of Biochemistry 
University of Texas Southwestern Medical Center 

Presentation:

"REGULATION AND FUNCTION OF NADPH METABOLISM IN CELL GROWTH"

Abstract:

NADPH is the major reducing currency that drives the synthesis of macromolecules and fuels the antioxidant systems to protect cells from oxidative stress. Dysregulation of NADPH metabolism has been linked to many human pathologies, including cancer, neurodegeneration, and aging, yet regulation of this process remains poorly understood. NADPH levels are determined by NAD kinases (NADKs) - metabolite kinases that phosphorylate NAD+ molecules to make NADP+ (oxidized form of NADPH), a limiting substrate for NADPH generation. Human cells encode two NADKs: cytosolic NADK and mitochondrial NADK2, which provide reducing power in each cell compartment. Using NAD kinases as a tool to modulate specific NADPH pools, our research efforts are focused on understanding how cells and organisms control and regulate compartment-specific NADPH metabolism. Our ultimate goal is to exploit vulnerabilities in NADPH metabolism to treat disease.

Hosts: Dr. Issam Ben-Sahra, Assistant Professor of Biochemistry and Molecular Genetics and Dr. Naveep S. Chandel, Professor of Medicine (Pulmonary and Critical Care) and Biochemistry and Molecular Genetics

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Mar

16

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Mar

17

Neuroscience Seminar Series: Edwin Chapman Ph.D

Chicago - 12:00 PM - 1:00 PM

CURRENT RESEARCH:

Membrane Trafficking, Fusion, and Synaptic Transmission

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Mar

17

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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Mar

22

CDB Faculty Seminar: Robert Vassar, PhD

Chicago - 12:00 PM - 1:00 PM

CDB Faculty Seminars Presents:

“Title TBD"

Robert Vassar, Ph.D.
Scientific Director of Behavioral Neurology
Davee Professor of Alzheimer Research
Departments of Neurology (Behavioral Neurology) and
Cell and Developmental Biology

Wednesday, March 22nd, 2023
12:00–1:00 PM

Simpson Querrey Auditorium, SQ 1-230

For more information please contact cdb@northwestern.edu
Click here to subcribe to the CDB Seminar Series listserv.

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Mar

23

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Mar

23

CAN SEMINAR SERIES: Weizhe Hong: "Understanding the Social Brain"

Chicago - 2:00 PM - 3:00 PM

Abstract:

Social interactions between individuals and among groups are a hallmark of human society and are critical to the physical and mental health of a wide variety of species including humans. The central goal of our lab is to study the fundamental principles of how social behavior is regulated in the brain. We are particularly interested in prosocial behavior that animals display to benefit other individuals. We study how neural circuits and the underlying computation regulate social behavioral decisions within a single brain as well as how emergent inter-brain neural properties arise from social interactions between individuals.
JPEG headshot?

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Mar

24

BMG Journal Club: Alexander Lee and Shimaa Soliman, PhD

Chicago - 1:00 PM - 2:00 PM

Presenters:

Alexander Lee, PhD Candidate, Biochemistry and Molecular Genetics, Kelleher and Foltz Labs

Shimaa Soliman, PhD, Postdoctoral Fellow, Biochemistry and Molecular Genetics, Shilatifard Lab

The BMG Journal Club is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience.

Refreshments will be provided.

 

 

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Mar

24

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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Mar

24

Chicago Cytoskeleton Meeting

Chicago - 3:00 PM - 6:00 PM

Chicago Cytoskeleton Meeting in person!

 

March 24  3:00 – 6:00 PM  

Simpson Querrey Auditorium, SQ 1 -230

303 E. Superior Street, Chicago, IL 60611

Northwestern, Feinberg School of Medicine

 

The Chicago Cytoskeleton is a forum for cytoskeletal researchers from the greater Chicago area to meet, hear great talks, exchange ideas, and socialize. For additional information, please visit: https://chicagocytoskeleton.net/

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Mar

27

Pharmacology Seminar Series - Elena Oancea, PhD

Chicago - 3:00 PM - 4:00 PM

Elena Oancea, PhD
Assosiate Professor of Medical Science
Department of Molecular Pharmacology, Physiology and Biotechnology
Brown University

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Mar

29

CDB Trainee Seminar Series Presents: Eve Suva and Bella Han

Chicago - 3:30 PM - 5:30 PM

CDB Trainee Seminars Presents:

“Title TBD"

Eve Suva
Graduate Student, Mitchell Lab
3:30-4:00pm

“Title TBD"

Bella Han
Research Technologist, Shukla Lab
4:00-4:30pm

Refreshments to follow
4:30-5:30pm

Wednesday, March 29th, 2023
*NEW TIME* 3:30-5:30 PM

Simpson Querrey Auditorium, SQ 1-230

For more information please contact cdb@northwestern.edu
Click here to subcribe to the CDB Seminar Series listserv.

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Mar

30

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Mar

31

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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Apr

05

CDB Faculty Meeting

No Location - 12:00 PM - 1:00 PM

Cell & Developmental Biology Department Faculty Meeting

Meeting details disseminated via listserv. If you believe you missed an announcement, please email us at cdb@northwestern.edu.

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Apr

06

BMG Seminar: Jason Gestwicki, PhD, University of California San Francisco (UCSF)

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry & Molecular Genetics presents:

Jason Gestwicki, PhD
Professor, Department of Pharmaceutical Chemistry
Associate Director of the Institute for Neurodegenerative Diseases
University of California San Francisco (UCSF)

Presentation:

"Targeting Protein-Protein Interactions to Treat Protein Misfolding Diseases"

Abstract:

To maintain protein homeostasis (proteostasis), each cell must carefully balance the decision to retain or degrade a protein. This decision is not always made correctly, as apparent in neurodegenerative diseases, where misfolded proteins accumulate in diseases neurons. Thus, there is interest in better understanding how cells maintain proteostasis, with the goal of finding ways that balance can be therapeutically restored. For each protein, the decision to “degrade” is typically driven by direct, physical protein-protein interactions (PPIs). For example, chaperone binding is used to discern whether the protein is unfolded. Likewise, PPIs between the protein, chaperones and the ubiquitin conjugation machinery are often used to drive turnover. Our goal is to understand and perturb these PPIs using a chemical biology strategy. Here, we focus on an interesting and relatively under explored category of PPIs: those that occur at N- and C-termini. The chemical environment at the ends of a polypeptide is often unique (e.g. pKa values, dynamics) and these regions can be a hotspot for post-translational modifications (PTMs). Thus, new strategies might be required to chemically manipulate terminal PPIs. Here, we will discuss progress on developing methods towards that goal, including high throughput methods for studying terminal PPIs.

Host: Dr. Marc Mendillo, Assistant Professor, Biochemistry and Molecular Genetics

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Apr

06

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Apr

07

BMG Journal Club: Yuki Aoi, PhD and Saeid Mohammad Parast, PhD

Chicago - 1:00 PM - 2:00 PM

Presenters:

Yuki Aoi, PhD, Postdoctoral Fellow, Biochemistry and Molecular Genetics, Shilatifard Lab

Saeid Mohammad Parast, PhD, Postdoctoral Fellow, Biochemistry and Molecular Genetics, Shilatifard Lab

The BMG Journal Club is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience.

Refreshments will be provided.

 

 

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Apr

07

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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Apr

12

CDB Seminar Series Presents: Allon Klein, PhD, Harvard Medical School

Chicago - 12:00 PM - 1:00 PM

CDB "EXPERTS-IN-THE-FIELD" SEMINAR PRESENTATION: 

"Title TBD"

Allon Klein, Ph.D.
Associate Professor
Department of Systems Biology
Harvard Medical School
Boston, Massachusetts

Wednesday, April 12, 2023
12:00–1:00 PM

Simpson Querrey Auditorium, SQ 1-230
303 E. Superior St., Chicago

Host: Dr. Yogesh Goyal, Ph.D.
Assistant Professor
Department of Cell & Developmental Biology
Center for Synthetic Biology

For more information, please contact cdb@northwestern.edu 
To subscribe to the CDB Seminar Series listserv, please visit https://www.feinberg.northwestern.edu/sites/cdb/about/contact-us/index.html

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Apr

13

BMG Seminar: Joseph Takahashi, PhD, UT Southwestern Medical Center, Dallas, TX

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry & Molecular Genetics presents:

Joseph Takahashi, PhD
Professor and Chair, Department of Neuroscience
Loyd B. Sands Distinguished Chair in Neuroscience
University of Texas Southwestern Medical Center

Host: Dr. Clara Peek, Assistant Professor of Biochemistry and Molecular Genetics

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Apr

13

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Apr

14

Neuroscience Seminar Series: Dietmar Plenz Ph.D

Chicago - 12:00 PM - 1:00 PM

Dr. Plenz is Chief of the Section on Critical Brain Dynamics in the Intramural Research Program at the NIMH.  He attended college at the Universities of Mainz and Tuebingen, Germany. Under the supervision of Prof. Valentino Braitenberg and Ad Aertsen, he received his Ph.D. in 1993 at the Max-Planck Institute of Biological Cybernetics/University Tuebingen, where he pioneered the development of in vitro cortex networks to study the emergence of neuronal population dynamics.  During his 3 year postdoctoral fellowship with Stephen T. Kitai at the University of Tennessee, Memphis, he developed advanced cortex-forebrain neuronal cultures that allowed him to identify the mechanisms of distinct activity patterns that characterize normal and abnormal population dynamics in cortex and basal ganglia. Dr. Plenz joined the NIMH as a Tenure-track Investigator in 1999 and was promoted to Senior Investigator with tenure in 2006.  His laboratory combines electrophysiological and imaging techniques and neural modeling to study the self-organization of neuronal networks.

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Apr

14

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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Apr

17

Pharmacology Seminar Series - Yang Yang, PhD

Chicago - 3:00 PM - 4:00 PM

Yang Yang, PhD
Assistant Professor of Medicinal Chemistry and Molecular Pharmacology
Purdue University

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Apr

19

CDB Faculty Seminar: Erica Davis, Ph.D.

Chicago - 12:00 PM - 1:00 PM

CDB Faculty Seminars Presents:

“Title TBD"

Erica Davis, Ph.D.
Associate Professor
Departments of Pediatrics and
Cell & Developmental Biology

Wednesday, April 19th, 2023
12:00–1:00 PM

Simpson Querrey Auditorium, SQ 1-230

For more information please contact cdb@northwestern.edu
Click here to subcribe to the CDB Seminar Series listserv.

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Apr

20

BMG Seminar: Gary H. Karpen, PhD, University of California, Berkeley

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry & Molecular Genetics presents:

Gary H. Karpen, PhD
Professor, Department of Molecular and Cell Biology
Senior Faculty Scientist, Lawrence Berekley National Lab
University of California Berekley

Presentation:

"New insights into formation, organization and function of heterochromatin condensates"

Abstract: 

The possibility that dynamic biophysical mechanisms, in particular liquid-liquid phase separation (LLPS), regulate formation and function of chromatin domains is exciting, because it can explain previously enigmatic observations about nuclear structure and function.  We previously demonstrated that formation of one important chromatin domain, called heterochromatin, behaves as a condensate in vivo in fruit flies and mammals, and thus is likely initially formed via LLPS.  I will describe recent progress on elucidating the critical components and interactions responsible for heterochromatin condensate formation in vivo. I will then focus on whether condensates and associated properties such as liquidity, are directly required for heterochromatin organization, functions and dynamics. Finally, I will discuss recent progress in understanding the interplay between heterochromatin and nucleoli, two condensates with distinct but linked cellular functions, with respect to their de novo formation and functions in early Drosophila embryos.

Host: Dr. Daniel Foltz, Professor of Biochemistry and Molecular Genetics

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Apr

20

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Apr

21

Neuroscience Seminar Series: Jeremy Day Ph.D

Chicago - 12:00 PM - 1:00 PM

Research Areas:


Neurogenetics, substance use disorders, learning and memory, epigenetics, gene regulation and gene editing.

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Apr

21

BMG Journal Club: Olivia Vidal-Cruchez, PhD and Pedro A. Avila-Lopez, PhD

Chicago - 1:00 PM - 2:00 PM

Presenters:

Olivia Vidal-Cruchez, PhD, Postdoctoral Fellow, Biochemistry and Molecular Genetics, Ben-Sahra Lab

Pedro A. Avila-Lopez, PhD, Postdoctoral Fellow, Biochemistry and Molecular Genetics, Lauberth Lab

The BMG Journal Club is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience.

Refreshments will be provided.

 

 

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Apr

21

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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Apr

21

Chicago Cytoskeleton Meeting

Chicago - 3:00 PM - 6:00 PM

Chicago Cytoskeleton Meeting in person!

 

April 21  3:00 – 6:00 PM  

Simpson Querrey Auditorium, SQ 1 -230

303 E. Superior Street, Chicago, IL 60611

Northwestern, Feinberg School of Medicine

 

The Chicago Cytoskeleton is a forum for cytoskeletal researchers from the greater Chicago area to meet, hear great talks, exchange ideas, and socialize. For additional information, please visit: https://chicagocytoskeleton.net/

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Apr

26

CDB Trainee Seminar Series Presents: Annmarie Dominguez and Jeanne Quinn

Chicago - 3:30 PM - 5:30 PM

CDB Trainee Seminars Presents:

“Title TBD"

Annmarie Dominguez
Graduate Student, Arispe Lab
3:30-4:00pm

“Title TBD"

Jeanne Quinn
Graduate Student, Gottardi Lab
4:00-4:30pm

Refreshments to follow
4:30-5:30pm

Wednesday, April 26th, 2023
*NEW TIME* 3:30-5:30 PM

Simpson Querrey Auditorium, SQ 1-230

For more information please contact cdb@northwestern.edu
Click here to subcribe to the CDB Seminar Series listserv.

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Apr

27

BMG Seminar: Matthew D. Shoulders, PhD, Massachusettes Institute of Technology (MIT), Cambridge, MA

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry & Molecular Genetics presents:

Matthew D. Shoulders, PhD
Professor, Department of Chemistry
Massachusettes Institute of Technology

Host: Dr. Marc Mendillo, Assistant Professor of Biochemistry and Molecular Genetics

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Apr

27

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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Apr

27

CAN SEMINAR SERIES: Dr. Craig Powell

Chicago - 2:00 PM - 3:00 PM

Dr. Craig Powell

Professor
Director, Civitan International Research Center
Chair, Department of Neurobiology
Virginia B. Spencer Endowed Chair
Research Areas
Autism, intellectual disability, cognitive dysfunction

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Apr

28

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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May

01

Department of Pharmacology Seminar - Neville Sanjana, Ph.D.

Chicago - 3:00 PM - 4:00 PM

Neville Sanjana, Ph.D.
Assistant Professor, Department of Biology
Center for Genomics and Systems Biology
New York University

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May

03

CDB Faculty Meeting

No Location - 12:00 PM - 1:00 PM

Cell & Developmental Biology Department Faculty Meeting

Meeting details disseminated via listserv. If you believe you missed an announcement, please email us at cdb@northwestern.edu.

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May

04

BMG Seminar: Yin Shen, PhD, University of California San Francisco (UCSF)

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry & Molecular Genetics presents:

Yin Shen, PhD
Associate Professor
Institute for Human Genetics, Department of Neurology
University of California San Francisco (UCSF) 

Presentation:

"Characterize non-coding DNA variants in the human genome"

Abstract:

Advances in genome sequencing have led to the identification of hundreds of millions of genetic variants in the human population, with a fraction conferring risk for common illnesses such as diabetes, neurological disorders, and cancers. A significant barrier to understanding the genetic underpinnings of these complex diseases is the lack of functional annotation for disease-associated sequence variants, primarily because such variants are predominantly located within non-coding regions. However, research on the role of these candidate cis-regulatory elements and variants in disease pathogenesis has been hindered by a lack of knowledge of their biological function in relevant cell types. I will discuss our approaches to functional characterize candidate cis-regulatory elements and demystify how non-coding variants could contribute to human health and disease.

Host: Dr. Feng Yue, Professor of Biochemistry and Molecular Genetics and Pathology

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May

04

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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May

05

Neuroscience Seminar Series: Giandomenico Iannetti Ph.D

Chicago - 12:00 PM - 1:00 PM

We investigate fundamental questions about how humans and other animals cope with the world through perception and action. We are particularly interested in understanding the mechanisms that brains have evolved for the detection and the motor reaction to sudden and surprising environmental stimuli.

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May

05

BMG Journal Club: Ram Prosad Chakrabarty and Shashank Srivastava, PhD

Chicago - 1:00 PM - 2:00 PM

Presenters:

Shashank Srivastava, PhD, Postdoctoral Fellow, Biochemistry and Molecular Genetics, Foltz Lab

Ram Prosad Chakrabarty, DGP Graduate Student, Biochemistry and Molecular Genetics, Chandel Lab

The BMG Journal Club is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience.

Refreshments will be provided.

 

 

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May

05

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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May

08

Pharmacology Seminar Series - Yoseph Barash, PhD

Chicago - 3:00 PM - 4:00 PM

Yoseph Barash, PhD
Assistant Professor of Medicinal Chemistry and Molecular Pharmacology
Purdue University

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May

10

CDB Seminar Series Presents: Harmit Singh Malik, Ph.D., Fred Hutchinson Cancer Research Center, Seattle, WA

Chicago - 12:00 PM - 1:00 PM

CDB "EXPERTS-IN-THE-FIELD" SEMINAR PRESENTATION: 

"Title TBD"

Harmit Singh Malik, Ph.D.
Professor and Associate Director
Division of Basic Sciences
HHMI Investigator
Member, US National Academy of Sciences
Fred Hutchinson Cancer Research Center
Seattle, Washington

Wednesday, May 10, 2023
12:00–1:00 PM

Simpson Querrey Auditorium, SQ 1-230
303 E. Superior St., Chicago

Host: Dr. Vipul Shukla
Assistant Professor
Department of Cell and Developmental Biology

For more information, please contact cdb@northwestern.edu
To subscribe to the CDB Seminar Series listserv, please visit https://www.feinberg.northwestern.edu/sites/cdb/about/contact-us/index.html

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May

11

BMG Seminar: Jian Jin, PhD, Icahn School of Medicine at Mount Sinai, New York, NY

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry & Molecular Genetics presents:

Jian Jin, PhD
The Mount Sinai Endowed Professor in Therapeutics Discovery
Director, Mount Sinai Center for Therapeutics Discovery
Professor, Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience at the Icahn School of Medicine at Mount Sinai
Co-Leader of the Cancer Clinical Investigation Program at The Tisch Cancer Institute at Mount Sinai

Host: Dr. Lu Wang, Assistant Professor of Biochemistry and Molecular Genetics

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May

11

Immunology Discussion Club

Chicago - 12:00 PM - 1:00 PM

The Northwestern Immunology Discussion Club meets on Thursdays from 12:00pm to 1:00pm and is led by Dr. Booki Min. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative!

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May

12

Neuroscience Seminar Series: Sean Escola Ph.D

Chicago - 12:00 PM - 1:00 PM

Research Interests:

Cognitive/Systems Neuroscience, Computational Psychiatry, Computation and Theory, Motor Systems, Theoretical Neuroscience.

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May

12

Bacteriology Journal Club

Chicago - 2:00 PM - 3:00 PM

Microbiology Journal Club is a weekly club that meets on the medical school campus to discuss recent journal articles and on-going research.

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