Education & Seminars
Our members are active member of the Feinberg community, speaking at and participating in a number of educational events around campus on a variety of epigentics-related topics.
Use the tabs below to browse listings of upcoming genetics-related seminars and events. For a schedule of additional Northwestern University and Feinberg School of Medicine events, visit the Feinberg Medical School Event Calendar or PlanIt Purple.
May
06
SQE Lecturer Series: "Thinking Outside the Chromosome: Interrogating Epigenetic Mechanisms in Non-Canonical Chromatin Species" with Yael David, PhD
Chicago - 10:00 AM - 11:00 AM
The Simpson Querrey Institute for Epigenetics presents:
Yael David, PhD
Associate Member, Chemical Biology Program
Memorial Sloan Kettering, NY
"Thinking Outside the Chromosome: Interrogating Epigenetic Mechanisms in Non-Canonical Chromatin Species"
Abstract:
Epigenetic regulation governs DNA-templated processes, playing a pivotal role in determining cell phenotype and fate. Disruption of epigenetic cascades is implicated in various disease states, notably cancer. Many of these pathological conditions involve significant chromosomal rearrangements, leading to the formation of non-canonical chromatin structures present in primary nuclei or enclosed in spatially distinct micronuclei. Recently, we adopted a mechanistic approach to explore the properties of these unique non-chromosomal structures, unveiling substantial epigenetic contributions to their regulation.
Our investigations revealed that micronuclei undergo altered epigenetic landscapes upon departure from the nucleus. Importantly, they retain these epigenetic 'scars' upon reintegrating into primary nuclei, contributing to epigenetic reprogramming and heterogeneity in cancer. Shifting our focus, we delved into the covalently closed circular DNA (cccDNA) minichromosome of the Hepatitis B Virus (HBV). This minichromosome, formed from viral DNA and human histones following infection, undergoes chromatinization, driving the expression of the key viral oncogene, HBx, and facilitating viral infection. Our elucidation of this novel mechanism has allowed us to disrupt infection by inhibiting histone remodeling, presenting a potential first-in-class therapy for HBV.
In my seminar, I will elaborate on how these exciting findings underscore the critical role of chromatin in biomedical events. Additionally, I will discuss how a fundamental understanding of these processes can pave the way for identifying new therapeutic avenues.
May
10
SQE Forum on Biochemistry, Epigenetics, and Metabolism (BEaM)
Chicago - 1:00 PM - 2:00 PM
The BEaM Forum is a data group where Simpson Querrey Institute for Epigenetics members present ongoing work being conducted. It is a great opportunity to get feedback on your work from colleagues, and to make new connections and foster new collaborations within the Institute.
Our forum will normally be held every other week from 1:00-2:00 p.m. Presenters will give a 10-minute talk with 10 minutes for discussion and questions. We welcome presentation from students, techs, postdocs, and PIs. Presenting work-in-progress is always encouraged!
Pizza and soda provided.
Presenters:
Milad Alasady, Research Associate, Biochemistry & Molecular Genetics, Mendillo Lab
Anika Wilen, Research Technologist 1, Neurology, Savas Lab
Vaibhav Patil, Postdoctoral Scholar, Neurology
May
02
BMG Seminar: Kapil Bhalla, MD, University of Texas MD Anderson Cancer Center, Houston, TX
Chicago - 10:00 AM - 11:00 AM
The Department of Biochemistry and Molecular Genetics presents:
Kapil Bhalla, MD
Professor, Department of Leukemia, Division of Cancer Medicine and Kelcie Kana Research Chair
University of Texas MD Anderson Cancer Center
Presentation:
"Pre-clinical efficacy of targeted inhibition of Chromatin remodeler ATPases in models of high-risk AML"
Abstract: BRG1 (SMARCA4) and BRM (SMARCA2) are the core ATPase within the multi-protein, ATP-dependent, chromatin remodeling BAF complexes that regulate gene transcription. FHD-286 is a potent, selective, orally administered, inhibitor of BRG1/BRM in early clinical development as a therapy for AML. This presentation will describe the pre-clinical in vitro and in vivo efficacy FHD-286 in models of high-risk AML. Treatment with FHD-286 for 4 to 7 days induced morphologic features of differentiation and loss of viability in AML cell lines and patient-derived (PD) AML cells with MLLr or mtNPM1. Notably, FHD-286 also induced significant lethality in Menin inhibitor (MI) resistant AML cell lines and PD AML cells lacking Menin mutations. ChIP-Seq, ATAC-Seq, RNA-Seq, Mass spectrometry and CyTOF analyses data will be presented to define gene-expressions alterations that correlate with the lethal effects of FHD-286. Findings from a domain-specific CRISPR screen targeting epigenetic regulators revealed significant co-enrichments with FHD-286 treatment of the gRNAs against BRD4 and LSD1, suggesting them as the epigenetic mediators of FHD-286 resistance. Co-treatment with FHD-286 and venetoclax, BET inhibitor, decitabine or MI (SNDX-50469) exerted synergistic lethality in AML cell lines and PD AML cells with MLL1r or mtNPM1. In a PD xenograft (PDX) model of MLL1r AML with FLT3 mutation, monotherapy with FHD-286 for 4 to 6-weeks was significantly effective in reducing AML burden and improving overall survival. Separately, in vivo FHD-286 treatment vs vehicle control, also significantly inhibited the AML-initiating potential of AML stem progenitor cells. Additionally, co-treatment with FHD-286 and decitabine or BET inhibitor vs each drug alone, or vehicle control, significantly reduced the AML burden and improved survival, without significant toxicity in the PDX models of MLLr or mtNPM1, as well as of MECOM rearranged AML. Finally, co-treatment with FHD-286 and MI was significantly more effective than each drug alone in reducing the AML burden and overall survival of mice engrafted with a separate PDX model of AML cells with mtNPM1 and FLT3-ITD, without significant toxicity. These findings demonstrate the pre-clinical efficacy of FHD-286-based rational combinations and support their clinical testing in the high-risk AML models.
Host: Dr. Lu Wang, Assistant Professor, Biochemistry and Molecular Genetics
May
03
BMG Journal Club
Chicago - 1:00 PM - 2:00 PM
The BMG Journal Club is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience.
Refreshments will be provided.
May
09
BMG Seminar: Scott B Rothbart, PhD, Van Andel Institute, Grand Rapids, MI
Chicago - 10:00 AM - 11:00 AM
The Department of Biochemistry & Molecular Genetics presents:
Scott B Rothbart, PhD
Professor, Department of Epigenetics
Co-Director, NCI T32 Cancer Epigenetics Training Program
Van Andel Institute, Grand Rapids, MI
Presentation:
"Mechanisms and therapeutic targeting of chromatin modification crosstalk"
Abstract:
My lab studies basic cellular and molecular mechanisms regulating chromatin accessibility, interaction, and function. We are particularly interested in the interconnected molecular activities of proteins that write, erase, and read histone post-translational modifications (PTMs) and DNA methylation, and we seek to understand roles for these chromatin modifications in the regulation of transcription, DNA replication, chromatin organization, and the preservation of cell identity. Our studies are facilitated by the development and improvement of tools and technologies for the field. As chromatin modifiers and associated proteins are frequently mutated and dysregulated in human diseases, most notably cancer, our studies are also revealing pathological mechanisms associated with chromatin dysregulation, identifying new targets for drug discovery, and providing mechanistic rationale for multi-targeted therapeutic approaches to improve patient outcomes. Direct translation of our findings to clinical trials is facilitated by an Epigenetic Therapies NCI SPORE grant (the second discipline-based SPORE awarded) and the Van Andel Institute-Stand Up to Cancer Epigenetics Dream Team, where I participate as a Basic Science Investigator.
Host: Dr. Shannon Lauberth, Associate Professor of Biochemistry and Molecular Genetics
May
17
BMG Journal Club
Chicago - 1:00 PM - 2:00 PM
The BMG Journal Club is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience.
Refreshments will be provided.
Apr
26
Precision Oncology: Beyond Mutations (2024 OncoSET Symposium)
Chicago - 8:00 AM - 3:30 PM
On Friday, April 26th, the OncoSET Symposium will provide healthcare professionals with state of the art information related to new advances in precision medicine looking beyond mutations in cancer treatment and care. The program will focus on improving the detection of fusions and their therapeutic vulnerabilities, enhancing future incorporation of multiomics assays into management decisions and discussing established and future molecular imaging targets. Participants will learn strategies for translating advances in precision medicine to their clinical practice.
Apr
26
FCVRRI Research in Progress - Maggie Fain
Chicago - 11:00 AM - 12:00 PM
Talk title - Exploring Cardiac-Renal Crosstalk in the Context of Sodium Glucose Cotransporter 2 Inhibitors
Apr
26
Fulbright Research/Study/Arts Application Workshop
Evanston - 12:00 PM - 1:00 PM
Interested in pursuing research, study, or the arts abroad? Attend an application workshop to learn about the Fulbright application process at Northwestern. We will discuss application components and successful application strategies. You do not need a draft of your essays, but will benefit most if you have a clear vision of your project.
Apr
26
Neuroscience Seminar Series: "Dendritic Spines: Old News, New Applications"
Chicago - 12:00 PM - 1:00 PM
Andrew Tan, Ph.D.
Assistant Professor, Department of Neurology, Yale University
Biography
My research interests focus on spinal cord injury (SCI) pathology, particularly mechanisms underlying neuropathic pain and spastic movement disorders. My long-term goal is to identify and assess novel targets and strategies that can help restore normal function after SCI. My hope is that our efforts will eventually lead to more effective and safe clinical therapies.
As the Principal Investigator (PI) of US Federal awards and privately funded grants, I have applied my expertise toward managing the execution of a broad range of projects, and have developed strong collaborations with domestic and international teams. As an Associate Director of the Center for Neuroscience and Regeneration Research at the West Haven VA Medical Center, I currently supervise a wonderful team of students, postdocs, and junior faculty in our SCI/D research program. Our published research has utilized in vitro and in vivo approaches, including a combination of anatomical analyses, behavioral assessment, viral-based gene therapy, and whole-animal electrophysiological techniques.
Over the past decade, my team has laid the groundwork demonstrating that maladaptive dendritic spine remodeling within nociceptive or motor reflex circuits underlies SCI-induced hyperexcitability disorders, i.e., neuropathic pain and spasticity. This body of work has also demonstrated for the first time that the Rac1-PAK1 pathway is a key mechanism involved in maintaining chronic pain and spinal motor reflex dysfunction. A core implication of these insights is that dendritic spine profiles may serve as a morphological correlate for sensory-motor hyperexcitability disorders, and could be used to predict therapeutic-drug response. Recently, we pioneered the use of long-term, in vivo two-photon imaging assays that we now use to investigate the relationship between dendritic spine dynamics in the spinal dorsal horn and neuropathic pain.
Apr
26
Searle Center Graduate Student Programs Info Session
Evanston - 1:00 PM - 3:00 PM
Looking to branch out as a teacher? Join us at our upcoming Graduate Student Programs Info Session!
Graduate students are invted to learn about Searle's Programs from current participants and Searle staff. You will have the opportunity to mingle, ask questions ,and learn more about how the Searle Center can support your pedagogical development. Food and drinks will be available!
Representatives from the following programs will be present:
- Reflective & Effective Teaching
Applications and registration for the 2024-2025 academic year are open until Monday, May 20, 2024!
Apr
26
Bacteriology journal club
Chicago - 2:00 PM - 3:00 PM
During bacteriology journal club, students and post-docs present their most recent research in progress or a bacteriology article of their choice
Apr
29
Providing Effective Feedback to Students: STEM and Social Sciences Perspectives
Evanston - 12:00 PM - 1:30 PM
During this workshop, participants will consider different methods of providing effective feedback on a variety of student assignments, from homework and exams to lab reports and essays. We will discuss strategies for providing detailed, specific feedback that allow students to focus on how to improve instead of focusing on mistakes made. Participants will practice providing feedback on mock assignments. We will also explore how to navigate difficult or emotional discussions with students about grades.
Facilitated by Graduate Teaching Fellows:
Gerpha Gerlin, Anthropology PhD Candidate
Clover Moisanu, Chemistry PhD Candidate
Apr
29
Lurie Cancer Center Research-In-Progress Seminar Series
Chicago - 1:00 PM - 2:00 PM
Leveraging NKG2D Signaling through Anti-MIC Immunotherapy
to Promote Intratumoral CD8 T cell Stemness
Tyler Smith, PhD
Postdoctoral Fellow (J. Wu Lab)
Northwestern University Feinberg School of
Medicine
Lunch will be provided.
All members of the Northwestern
Medicine community are welcome to
attend
Apr
29
Pharmacology Faculty Candidate | Steffen Lindert, PhD Using Computers to Derive Protein Structure from Sparse Data – A Case Study for Mass Spectrometry"
Chicago - 3:00 PM - 4:00 PM
Title: "Using Computers to Derive Protein Structure from Sparse Data – A Case Study for Mass Spectrometry."
Abstract: Mass spectrometry-based methods such as covalent labeling, surface induced dissociation (SID) or ion mobility (IM) are increasingly used to obtain information about protein structure. However, in contrast to other high-resolution structure determination methods, this information is not sufficient to deduce all atom coordinates and can only inform on certain elements of structure, such as solvent exposure of individual residues, properties of protein-protein interfaces or protein shape. Computational methods are needed to predict high-resolution protein structures from the mass spectrometry (MS) data. Our group develops algorithms within the Rosetta software package that use mass spectrometry data to guide protein structure prediction. These algorithms can incorporate several different types of mass spectrometry data, such as covalent labeling, surface induced dissociation, and ion mobility. We developed scoring functions that assess the agreement of residue exposure with covalent labeling data, the agreement of protein-protein interface energies with SID data and the agreement of protein model shapes with collision cross section (CCS) IM measurements. We subsequently rescored Rosetta models generated with de novo protein folding and protein-protein docking and we were able to accurately predict protein structure from MS labeling, SID and IM data. Future work is focusing on developing custom machine learning models to predict protein structure from MS data.
Steffen Lindert, PhD, Associate Professor of Chemistry and Biochemistry.
Bio: Steffen Lindert received his M.Sc. in Physics from the University of Leipzig in 2006 and his Ph.D. in Chemical and Physical Biology (Molecular Biophysics track) from Vanderbilt University in 2011. Co- advised by Prof. Jens Meiler and Prof. Phoebe Stewart, he worked on a combined experimental and computational project developing a program – EM-Fold – which folds proteins into medium resolution cryoEM density maps. After finishing his Ph.D., he joined the laboratory of Prof. Andy McCammon at the University of California, San Diego, as a postdoctoral fellow. His research focused on macromolecular simulations of proteins involved in cardiomyocyte contraction and computer-aided drug discovery. He was awarded a prestigious postdoctoral fellowship from the American Heart Association. He started his research group at OSU in August of 2015. Research in the lab focuses on the development and application of computational techniques for modeling biological systems, with the goal of gaining a deeper understanding of biomolecular processes, predicting protein structure de novo with the use of sparse experimental data, and discovering new drugs.
Apr
29
Fulbright English Teaching Assistantships Information Session
Evanston - 4:00 PM - 5:00 PM
Are you interested in teaching English abroad after graduation? The U.S. Department of State’s Fulbright U.S. Student Program places English Teaching Assistants (ETAs) in classrooms abroad to provide support to local English teachers. ETAs strengthen English language instruction in seventy-five countries world-wide while serving as cultural ambassadors of the United States. Host institutions range from elementary and secondary schools to university-level language departments. Stop by the info session to meet the campus contact and learn more.
Apr
30
CDB Experts-in-the-field Seminar Series Presents: Sun Hur, Harvard University
Chicago - 9:30 AM - 10:30 AM
CDB "EXPERTS-IN-THE-FIELD" SEMINAR PRESENTATION:
"Nucleic acid-driven self-assemblies: transcriptional regulation and beyond"
Sun Hur, Ph.D.
Professor of Biological Chemistry and Molecular Pharmacology
Oscar M. Schloss, MD Professor of Pediatrics
Harvard University
Boston, Massachusetts
Wednesday, April 30, 2024
9:30–10:30 AM
Baldwin Auditorium, Lurie 1-123
303 E. Superior St., Chicago
Host: Dr. Vipul Shukla
Assistant Professor
Department of Cell & Developmental Biology
The department hosts guest lectures every second Wednesday from 12-1 PM. Calendar invites are disseminated in advance with event details. Contact cdb@northwestern.edu for additional details or sign-up for our listserv at https://www.feinberg.northwestern.edu/sites/cdb/about/listserv.html#listserv
Apr
30
DGP Student Thesis Seminar - Sakshi Khurana - Daniel Foltz Lab
Chicago - 11:00 AM - 12:00 PM
Title of Presentation:
"Non-Canonical Functions of CENP-F in Chromosomal and Genomic Instability"
This is a hybrid event. For Zoom access or more information, email rachael.hill@northwestern.edu.
Apr
30
Lurie Cancer Center Basic Research Seminar: Cancer Cell State and The Immune Microenvironment Coordinately Regulate Breast Cancer Metastasis
Chicago - 11:00 AM - 12:00 PM
The Lurie Cancer Center Basic Research Seminar presents:
Cancer Cell State and The Immune Microenvironment Coordinately Regulate Breast Cancer Metastasis
Andrew Ewald, PhD
Virginia DeAcetis Professor of Breast Cancer Research
Professor and Director, Department of Cell Biology
Professor of Oncology and Co-Director, Cancer Invastion and Metastasis Program
Sideny Kimmel Comprehensive Cancer Center
Apr
30
M-I Dept. Seminar / Inhibition of Kaposi’s Sarcoma Associated Herpesvirus microRNAs in Primary Effusion Lymphoma
Chicago - 12:00 PM - 1:00 PM
Seminar Title:
Inhibition of Kaposi’s Sarcoma Associated Herpesvirus microRNAs in Primary Effusion Lymphoma
Speaker: Jesus Ortega, Graduate Student, Driskill Graduate Program
Topic:
Kaposi's Sarcoma Herpesvirus (KSHV) causes several human cancers, including the non-Hodgkin’s body cavity primary effusion lymphoma (PEL). In PEL, KSHV remains latent, expressing few proteins and several viral microRNAs (miRNAs). To date, specific challenges with KSHV biology have precluded effective viral miRNA loss-of-function studies. By exploring new mechanistic insights into miRNA turnover, I achieve robust miRNA inhibition, highlighting the essentiality of a viral miRNA mimic of miR-155 in sustaining viability and proliferation of patient-derived PEL.
Host: Dr. Eva Gottwein, Associate Professor, Dept. of Microbiology-Immunology
Apr
30
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
Apr
30
Pharmacology Seminar Series | Christopher Burge, PhD "Interpretable models to understand regulation of RNA splicing"
Chicago - 3:00 PM - 4:00 PM
Title: "Interpretable models to understand regulation of RNA splicing."
Abstract: Burge lab is developing fully interpretable models of RNA splicing and its regulation for improved understanding and various applications. They have developed a model of regulation from in vitro RNA binding data and splicing factor knockdown experiments called KATMAP that predicts precise patterns of activity, distinguishes direct from indirect effects, and detects cooperative activity. He will also discuss our findings that proteins of the Luc7 family recognize two distinct subclasses of 5’ splice sites, with implications leukemia, metabolic regulation and the evolution of introns.
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Christopher Burge, PhD, CSB Program Director; Professor of Biology; Extramural Member of KIICR; Associate Member of the Broad Institute, Massachusetts Institute of Technology.
May
01
CDB Faculty Meeting
No Location - 12:00 PM - 1:00 PM
Cell & Developmental Biology Faculty Meeting.
Departmental faculty meet every first Wednesday from 12-1 PM. Calendar invites with the meeting location are disseminated in advance. Please contact cdb@northwestern.edu for more information.
May
02
Fulbright English Teaching Assistantships Information Session
Evanston - 9:00 AM - 10:00 AM
Are you interested in teaching English abroad after graduation? The U.S. Department of State’s Fulbright U.S. Student Program places English Teaching Assistants (ETAs) in classrooms abroad to provide support to local English teachers. ETAs strengthen English language instruction in seventy-five countries world-wide while serving as cultural ambassadors of the United States. Host institutions range from elementary and secondary schools to university-level language departments. Stop by the info session to meet the campus contact and learn more.
May
02
James C. Houk Lecture in Motor Control: "Executing, Reinforcing and Refining Actions" with Rui Costa, DVM, PhD
Chicago - 2:00 PM - 3:30 PM
The Department of Neuroscience Presents:
The James C. Houk Lecture in Motor Control: "Executing, Reinforcing and Refining Actions"
Rui Costa, DVM, PhD
President and CEO
Allen Institute
Professor of Neuroscience
Columbia University
Abstract
The ability of animals to build individual repertoires based on the consequences of their actions is fascinating, and essential for survival. Understanding this process, i.e., how actions are learned through trial and feedback, requires mechanistic insight into how self-paced actions are initiated, how they can be selected/initiated again, and how feedback can refine their execution and organization. We use behavioral, genetic, electrophysiological, and optical approaches to gain this mechanistic insight. The combination of these approaches allowed us to uncover that dopaminergic neurons are transiently active before self-paced movement initiation. This activity is not action-specific and modulates both the probability of initiation and the vigor of future movements, but does not affect ongoing movement. Dopamine is supposed to have opposite effects on downstream striatal direct and indirect pathways. Contrary to what is classically postulated, we found that both striatal direct and indirect pathways are active during movement initiation. The activity in both pathways is action-specific and has complementary but different roles in movement, which are enabled by specific basal ganglia output circuits. Input from cortex seems to be critical to organize striatal activity, and cortico-striatal plasticity is necessary to select, reinforce and refine the specific neural and behavioral patterns that lead to desirable outcomes. These data invite new models on the mechanisms underlying self-paced movement initiation, and motor dysfunction in Parkinson’s disease. They also suggest that cortico-basal ganglia circuits play a generic role in learning to reinforce and refine task-relevant neural activity and behavioral patterns.
About Dr. Costa
Rui Costa is a neuroscientist and the current president and CEO of the Allen Institute. His laboratory develops and uses genetic, electrophysiological, optical, and behavioral approaches to investigate how the brain adaptively controls behavior and internal organ function. He did his PhD studies with Dr. Alcino Silva at UCLA and postdoctoral work with Dr. Miguel Nicolelis at Duke University. He then became section chief at the National Institutes of Health, an investigator of the Champalimaud Neuroscience Program, and a professor at Columbia University. He was co-director of Champalimaud Research and director/CEO of the Zuckerman Mind Brain Behavior Institute at Columbia University. He received several awards, such as the Young Investigator Award from SFN, the Ariëns Kappers Medal from the Royal Netherlands Academy of Arts and Sciences, and the Mina Bissell Award, and was knighted Commander of the Order of Sant'Iago da Espada by the President of Portugal. He is an elected member of EMBO, and the National Academy of Medicine.
About the James C. Houk Lecture in Motor Control
In 2020, the late James C. Houk, PhD, and his wife Antoinette made a bequest to establish the Dr. James Houk Graduate Fellowship in Neuroscience. Their gift provides funding to outstanding graduate students studying neurophysiology at Northwestern and supports the annual James C. Houk Lecture in Motor Control, presented by a renowned motor neuroscientist.
About James C. Houk, PhD
Dr. James C. Houk originally studied electrical engineering before receiving his PhD in physiology at Harvard University. As an assistant professor at Harvard, he studied Golgi tendon organs, muscle spindles and developed control models of muscle activation through neuronal circuits in the spinal cord.
Later, as an associate professor at Johns Hopkins Medical School, Houk began work on the central nervous system in behaving monkeys, work he continued at Northwestern University, after being recruited in 1978 as chair of the Department of Physiology (now Neuroscience). During this time, Houk also built a world-renowned systems neuroscience group within the department.
In 2001, after 23 years, Houk stepped down as chair to concentrate on multimodal approaches to studying how the nonlinear dynamics of microscopic modules in the brain give rise to its unique computational properties. He became particularly interested in the interplay between the basal ganglia, motor cortex and cerebellum.
May
03
Translational Research in Malignancies Symposium
Chicago - 8:00 AM - 12:15 PM
On Friday, May 3, 2024, the Robert H. Lurie Comprehensive Cancer Center of Northwestern University will host the Translational Research in Malignancies Symposium on the Chicago campus of Northwestern University. The focus of the program is "Resistance to Cancer Treatment".
Chairs:
Dr. Daniela Matei, MD
Dr. Roger Stupp, MD
Dr. Lucy Godley, MD, PhD
Lurie Cancer Center
Featured Speakers:
Ranjit Bindra, MD, PhD
Yale School of MedicineAlfred Zippelius, MD
University Hospital Basel
Atique Ahmed, PhD
Jaehyuk Choi, MD, PhD
Yogesh Goyal, PhD
Lurie Cancer Center
May
03
Sparkshop: Strengths-Based Strategies for Neurodiverse Students
Online - 11:00 AM - 11:30 AM
Based in the principles of Universal Design for Learning, this 30-minute virtual presentation offers evidence-driven teaching strategies to support neurodivergent student success at a broad level, breaking down barriers and building in choice to empower students to utilize and develop their own academic strengths.
May
03
Fulbright Research/Study/Arts Application Workshop
Evanston - 12:00 PM - 1:00 PM
Interested in pursuing research, study, or the arts abroad? Attend an application workshop to learn about the Fulbright application process at Northwestern. We will discuss application components and successful application strategies. You do not need a draft of your essays, but will benefit most if you have a clear vision of your project.
May
03
Bacteriology journal club
Chicago - 2:00 PM - 3:00 PM
During bacteriology journal club, students and post-docs present their most recent research in progress or a bacteriology article of their choice
May
03
DGP Student Thesis Seminar - Carolyn Lorch - Lisa Beutler Lab
Chicago - 2:00 PM - 4:00 PM
Title of Presentation:
"Sucrose overconsumption impairs AgRP neuron dynamics and promotes palatable food intake"
This is a hybrid event. For Zoom access or more information, email rachael.hill@northwestern.edu.
May
06
Fulbright English Teaching Assistantships Information Session
Evanston - 12:00 PM - 1:00 PM
Are you interested in teaching English abroad after graduation? The U.S. Department of State’s Fulbright U.S. Student Program places English Teaching Assistants (ETAs) in classrooms abroad to provide support to local English teachers. ETAs strengthen English language instruction in seventy-five countries world-wide while serving as cultural ambassadors of the United States. Host institutions range from elementary and secondary schools to university-level language departments. Stop by the info session to meet the campus contact and learn more.
May
07
Lurie Cancer Center Basic Research Seminar: The Pathobiology of Myeloproliferative Neoplasms
Chicago - 11:00 AM - 12:00 PM
The Lurie Cancer Center Basic Research Seminar presents:
The Pathobiology of Myeloproliferative Neoplasms
Shannon Elf, PhD
Assistant Professor
Department of Internal Medicine
Division of Hematology and Hematologic Malignancies
University of Utah
May
07
M-I Dept. Seminar / Visualizing Host-Virus Interactions at High Resolutions In Situ
Chicago - 12:00 PM - 1:00 PM
Title: Visualizing Host-Virus Interactions at High Resolutions In Situ
Speaker:
Yong Xiong, PhD, Professor, Yale School of Medicine, Dept. of Molecular Biophysics and Biochemistry
Topic:
Obtaining comprehensive structural descriptions of viruses and macromolecules within the natural cellular context holds immense potential for understanding fundamental biology and improving health. Here, we present the recent advances in in situ single-particle cryo-electron microscopy (cryo-EM), which allows us to view how HIV-1 capsids interact with antiviral compounds within the actual environment of the virus, as well as providing a detailed view of protein synthesis within human cells.
Host: Mojgan Naghavi, PhD, Professor, Dept. of Microbiology-Immunology
May
07
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
May
07
Fulbright Research/Study/Arts Application Workshop
Online - 7:00 PM - 8:00 PM
Interested in pursuing research, study, or the arts abroad? Attend an application workshop to learn about the Fulbright application process at Northwestern. We will discuss application components and successful application strategies. You do not need a draft of your essays, but will benefit most if you have a clear vision of your project.
May
08
Pharmacology Faculty Candidate: Smriti Sangwan, PhD "Molecular Mechanisms of Translational Regulation"
Chicago - 11:00 AM - 12:00 PM
Title: Molecular Mechanisms of Translational Regulation".
Abstrac: Sangwan is a structural biologist broadly interested in the signaling systems that ensure protein homeostasis. Defects in protein homeostasis are linked to disease conditions such as neurodegenerative diseases and cancer; however, our understanding of how these pathways organize in cells is limited due to their inherently transient nature. Sangwan will summarize her recent work on two proteins that are involved in protein quality control and are recruited to the translation machinery. One protein called eIF2A facilitates the translation of stress-response genes under conditions of cellular stress. Another protein called IRE1 monitors protein folding status and activates a transcription response upon protein misfolding stress, She utilized single-particle cryoEM, biochemical assays and next-generation sequencing to decipher their mechanism of action. Her work sets the stage for targeted drug design of these two proteins which play critical roles in various forms of cancer, infectious diseases, and protein misfolding disorders.
Smriti Sangwan, PhD; Post-Doctoral Fellow int he lab of Peter Walter, PhD; University of California, San Francisco
May
08
CDB Experts-in-the-field Seminar Series Presents: Cigall Kadoch, Dana-Farber Cancer Institute and Harvard Medical School
Chicago - 12:00 PM - 1:00 PM
CDB "EXPERTS-IN-THE-FIELD" SEMINAR PRESENTATION:
"Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Health and Disease"
Cigall Kadoch, PhD
Associate Professor
Department of Pediatric Oncology
Dana-Farber Cancer Institute and Harvard Medical School
Boston, Massachusetts
Wednesday, May 8, 2024
12:00–1:00 PM
Simpson-Querrey Auditorium, SQ 1-230
303 E. Superior St., Chicago
Host: Vipul Shukla
Assistant Professor
Department of Cell & Developmental Biology
Contact cdb@northwestern.edu for additional details or sign-up for our listserv at https://www.feinberg.northwestern.edu/sites/cdb/about/listserv.html#listserv
May
09
Games as a Tool for Active Learning
Evanston - 1:00 PM - 2:00 PM
Using interactive activities in the classroom can can help students engage with core concepts and topics in almost any subject and discipline. Games are one example of an interactive activity that can enable students to explore and engage with lessons. In this workshop, we will discuss the use of games as a tool for active learning. Participants will have the opportunity to explore ways they can incorporate games into their lectures and discussion sections.
Facilitated by Jennifer Lin, PhD candidate in Political Science
May
10
FCVRRI Series Seminar - Matthew Feinstein, MD
Chicago - 11:00 AM - 12:00 PM
Talk title: Cardiovascular Inflammation in (reverse) Translation: Insights from the Bedside
May
10
Neuroscience Seminar Series: "Feeling the Force: PIEZO ion channels in interoception"
Chicago - 12:00 PM - 1:00 PM
Kara Marshall, Ph.D - Assistant Professor, Baylor College of Medicine, Howard Hughes Medical Institute
Abstract
Our organs move, stretch, and contract during their every day function, and the nervous system detects these mechanical cues to drive physiology. PIEZO ion channels are mechanical force sensors, and we are unraveling their role in the physiology of the urinary and gastrointestinal tract and behavior.
May
10
Bacteriology journal club
Chicago - 2:00 PM - 3:00 PM
During bacteriology journal club, students and post-docs present their most recent research in progress or a bacteriology article of their choice
May
10
Joint Lurie Cancer Center Breast Cancer Research Program (BCRP) Seminar Series
Chicago - 3:00 PM - 4:00 PM
A new seminar series highlighting current multi-disciplinary cancer research at the Lurie Cancer Center
“The role of the death receptor Fas in breast cancer”
Marcus Peter, PhD
Professor
Medicine-Hematology Oncology Division
Northwestern University
Feinberg School of Medicine
“Investigating Environmental Risk Factors for Breast Cancer Using HSA-Cys34 Adductomics in the Sister Study”
William Funk, PhD
Associate Professor
Preventative Medicine-Cancer Epidemiology and Prevention
Northwestern University
Feinberg School of Medicine
Refreshments will be provided
May
13
Fulbright Research/Study/Arts Application Workshop
Evanston - 12:00 PM - 1:00 PM
Interested in pursuing research, study, or the arts abroad? Attend an application workshop to learn about the Fulbright application process at Northwestern. We will discuss application components and successful application strategies. You do not need a draft of your essays, but will benefit most if you have a clear vision of your project.
May
13
Lurie Cancer Center Core Technologies & Applications Seminar Series
Chicago - 1:00 PM - 2:00 PM
“Empowering Cancer Research and Drug Discovery with
High Throughput Technologies”
An Introduction to High Throughput Analysis Core at Northwestern University
Sara Fernandez Dunne, MS
Manager, High Throughput Analysis Lab
Northwestern University Feinberg School of Medicine
The Binding-centric Paradigm by Wet-lab and in Silico Screening
Chi-Hao Luan, PhD
Scientific Director, High Throughput Analysis Lab
Research Professor of Molecular Biosciences
Northwestern University Feinberg School of Medicine
Lunch is provided
May
13
Pharmacology Seminar Series | Teru Nakagawa, PhD "Structure and function of AMPA receptor auxiliary subunit complexes"
Chicago - 3:00 PM - 4:00 PM
Title: "Structure and function of AMPA receptor auxiliary subunit complexes"
Abstract: Functional modulation of excitatory synaptic transmission in mammalian brain is fundamental to information processing across neurons, while dysfunctions of synapses accompany various neurological and psychiatric disorders. AMPA-type ionotropic glutamate receptors (AMPA-Rs) are ligand-gated ion channels activated by neurotransmitter L-glutamate and mediate most of excitatory synaptic transmission in the central synapses. Our current focus is to uncover fundamental mechanisms that underly the gating and trafficking of AMPA-Rs, taking approaches in structural biology, biochemistry, cell biology, and electrophysiology. These efforts may lead to producing knowledge relevant to designing new therapeutics that could control synaptic activities under disease conditions, which include Alzheimer’s disease, intellectual disability, seizure, excitotoxicity, ALS, memory loss, addiction, schizophrenia, and autism. In this seminar I will present recent progress we made in our laboratory on the molecular structures of AMPA-R in complex with auxiliary subunits and their ion permeation mechanisms.
Teru Nakagawa, PhD
Professor, Department of Molecular Physiology and Biophysics, Center for Structural Biology, Vanderbilt Brain Institute
May
14
Lurie Cancer Center Basic Research Seminar: TET-Mediated Epigenetic Regulation in Cancer and Aging
Chicago - 11:00 AM - 12:00 PM
The Lurie Cancer Center Basic Research Seminar presents:
TET-Mediated Epigenetic Regulation in Cancer and Aging
Yun Nancy Huang, PhD
Associate Professor
Center for Epigenetics and Disease Prevention
Institute of Biosciences & Technology
Texas A&M University
May
14
M-I Dept. Seminar / Multidimensional Bacterial Profiles to Uncover Pathways to Resistance and Host-Immune Interactions
Chicago - 12:00 PM - 1:00 PM
Title:
Multidimensional Bacterial Profiles to Uncover Pathways to Resistance and Host-Immune Interactions
Speaker:
Tim van Opijnen, Ph.D
Boston Children’s Hospital
Division of Infectious Diseases
Associate Professor of Pediatrics
Harvard Medical School
Broad Institute of MIT
Topic:
Although vaccines and antibiotics have been historically successful in combating bacterial infections, limited vaccine coverage and the rise of antibiotic resistance emphasize the need to design new targeted treatment strategies. In an attempt to answer this call, we are developing platform technology that combines data from approaches including single cell, bulk and dualRNA-Seq, Tn-Seq, and CRISPRi into multidimensional bacterial profiles, that can be computationally mined to aid in developing drug and/or immune-enhancing approaches.
Host:
Bacteriology Graduate Students and Postdocs, coordinated by Graduate Student Marine LeBrun
May
14
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
May
14
Fulbright English Teaching Assistantships Information Session
Evanston - 4:00 PM - 5:00 PM
Are you interested in teaching English abroad after graduation? The U.S. Department of State’s Fulbright U.S. Student Program places English Teaching Assistants (ETAs) in classrooms abroad to provide support to local English teachers. ETAs strengthen English language instruction in seventy-five countries world-wide while serving as cultural ambassadors of the United States. Host institutions range from elementary and secondary schools to university-level language departments. Stop by the info session to meet the campus contact and learn more.
May
15
CDB Faculty Seminar Presents: Christian Petersen, PhD (Evanston Campus)
Chicago - 12:00 PM - 1:00 PM
CDB Faculty Seminars Presents:
"Regulation of whole-body regenerative ability in animals"
Christian Petersen, PhD
Professor
Department of Molecular Biosciences
Evanston, Northwestern
Wednesday, May 15, 2024
12:00–1:00 PM
Simpson Querrey Auditorium, SQ 1-230
Contact cdb@northwestern.edu for additional details or sign-up for our listserv at https://www.feinberg.northwestern.edu/sites/cdb/about/listserv.html#listserv
May
17
Neuroscience Seminar Series: "Neural circuit mechanisms of value-based decision-making"
Chicago - 12:00 PM - 1:00 PM
Christine Constantinople, Ph.D.
Assistant Professor, Center for Neural Science
New York University
Abstract:
The value of the environment determines animals’ motivational states and sets expectations for error-based learning. But how are values computed? We developed a novel temporal wagering task with latent structure, and used high-throughput behavioral training to obtain well-powered behavioral datasets from hundreds of rats that learned the structure of the task. We found that rats use distinct value computations for sequential decisions within single trials. Moreover, these sequential decisions are supported by different brain regions, suggesting that distinct neural circuits support specific types of value computations. I will discuss our ongoing efforts to delineate how distributed circuits in the orbitofrontal cortex and striatum coordinate complex value-based decisions.
May
17
Bacteriology journal club
Chicago - 2:00 PM - 3:00 PM
During bacteriology journal club, students and post-docs present their most recent research in progress or a bacteriology article of their choice
May
20
CDB Experts-in-the-field Seminar Series Presents: Krishna Shrinivas, Northwestern University
Chicago - 10:00 AM - 11:00 AM
CDB "EXPERTS-IN-THE-FIELD" SEMINAR PRESENTATION:
"Gene regulation and nuclear organization by biomolecular condensates"
Krishna Shrinivas, PhD
Assistant Professor
Department of Chemical and Biological Engineering
Northwestern University
Evanston Campus
Monday, May 20, 2024
10:00–11:00 AM
Simpson-Querrey Auditorium, SQ 1-230
303 E. Superior St., Chicago
Host: Vipul Shukla
Assistant Professor
Department of Cell & Developmental Biology
Contact cdb@northwestern.edu for additional details or sign-up for our listserv at https://www.feinberg.northwestern.edu/sites/cdb/about/listserv.html#listserv
May
20
Pharmacology Seminar Series | Axel Concepcion, PhD
Chicago - 3:00 PM - 4:00 PM
Axel Concepcion, PhD
Neubauer Family Assistant Professor of Biochemistry and Molecular Biology
Committee on Immunology
Research and Scholarly Interests: Biochemistry, Cell Signaling, Ion Transport, Molecular Immunology, Mouse Models, T Cells
May
21
M-I Dept. Seminar / Targeting Tuberculosis Adaptive (Mis)Translation as an Anti-Virulence Strategy
Chicago - 10:00 AM - 11:00 AM
Title: Targeting Tuberculosis Adaptive (Mis)Translation as an Anti-Virulence Strategy
Speaker: Babak Javid, PhD, Associate Professor, Division of Experimental Medicine, UCSF
Topic:
Rather than purely performing essential housekeeping functions, regulation of the protein synthesis machinery in bacterial pathogens contributes to critical adaptive functions. I will discuss how regulation of the stochastic error rate in protein synthesis in mycobacteria contributes to both antibiotic and host tolerance and potential ways to target this conserved pathway.
Host: M.-N. Frances Yap, PhD, Associate Professor, Dept. of Microbiology-Immunology
May
21
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
May
22
CANCELLED - CDB Faculty Seminar Presents: Yevgenia Kozorovitskiy, PhD (Evanston Campus)
Chicago - 12:00 PM - 1:00 PM
CDB Faculty Seminars Presents:
"Title TBD"
Yevgenia Kozorovitskiy, PhD
Associate Professor
Department of Neurobiology
Soretta and Henry Shapiro Professor of Molecular Biology
Evanston, Northwestern
Wednesday, May 22, 2024
12:00–1:00 PM
Simpson Querrey Auditorium, SQ 1-230
Contact cdb@northwestern.edu for additional details or sign-up for our listserv at https://www.feinberg.northwestern.edu/sites/cdb/about/listserv.html#listserv
May
22
Fulbright English Teaching Assistantships Information Session
Evanston - 12:00 PM - 1:00 PM
Are you interested in teaching English abroad after graduation? The U.S. Department of State’s Fulbright U.S. Student Program places English Teaching Assistants (ETAs) in classrooms abroad to provide support to local English teachers. ETAs strengthen English language instruction in seventy-five countries world-wide while serving as cultural ambassadors of the United States. Host institutions range from elementary and secondary schools to university-level language departments. Stop by the info session to meet the campus contact and learn more.
May
23
Fulbright Research/Study/Arts Application Workshop
Online - 9:00 AM - 10:00 AM
Interested in pursuing research, study, or the arts abroad? Attend an application workshop to learn about the Fulbright application process at Northwestern. We will discuss application components and successful application strategies. You do not need a draft of your essays, but will benefit most if you have a clear vision of your project.
May
24
Bacteriology journal club
Chicago - 2:00 PM - 3:00 PM
During bacteriology journal club, students and post-docs present their most recent research in progress or a bacteriology article of their choice
May
28
M-I Dept. Seminar / A Viral Noncoding Reshapes the Transcriptome of the Host Cell Through Novel Molecular Mechanisms
Chicago - 12:00 PM - 1:00 PM
Title: A Viral Noncoding Reshapes the Transcriptome of the Host Cell Through Novel Molecular Mechanisms
Speaker: Demián Cazalla, PhD, Department of Biochemistry, University of Utah School of Medicine
Topic:
Viruses express different kinds of noncoding RNAs (ncRNAs). Although identification of viral ncRNA species has been facilitated by the advent of high-throughput sequencing methods, ascribing functions to viral ncRNAs remains challenging. This shortcoming hinders our ability to understand how viruses create a cellular environment that permits the viral life cycle. I will describe our recent efforts to dissect the molecular functions of HSUR1, a viral ncRNA expressed by an oncogenic gammaherpesvirus that reshapes the transcriptome of the infected cell through novel molecular mechanisms.
Host: Jesus Ortega, Graduate Student, Lab of Eva Gottwein, PhD, Dept. of Microbiology-Immunology
May
28
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
May
28
Robert D. Goldman Lecture Presents: Dr. Jennifer Lippincott-Schwartz, PhD
Chicago - 3:30 PM - 4:30 PM
The Department of Cell and Developmental Biology and the Walter S. and Lucienne Driskill Graduate Program Lectures in Life Sciences invite you to the
Annual Robert D. Goldman Lecture
Please join us for a guest lecture and reception honoring Robert D. Goldman, PhD, and to celebrate his four decades of service as chair of the Department of Cell and Molecular Biology at Northwestern University Feinberg School of Medicine.
FEATURING:
Jennifer Lippincott-Schwartz, Ph.D.
Senior Group Leader,
Howard Hughes Medical Institute,
Janelia Research Campus, Ashburn, VA
"Emerging imaging technologies to study subcellular architecture, dynamics, and functions"
Abstract:
Powerful new ways to image the internal structures and complex dynamics of cells are revolutionizing cell biology and bio-medical research. In this talk, I will focus on how emerging fluorescent technologies are increasing spatio-temporal resolution dramatically, permitting simultaneous multispectral imaging of multiple cellular components. In addition, results will be discussed from whole cell milling using Focused Ion Beam Electron Microscopy (FIB-SEM), which reconstructs the entire cell volume at 4 voxel resolution. Using these tools, it is now possible to begin constructing a “organelle interactome”, describing the interrelationships of different subcellular organelles as they carry out critical functions. The same tools are also revealing new properties of organelles, including the roles of cytoskeletal elements like vimentin in controlling their organization and dynamism.
Tuesday, May 28, 2023
3:30–4:30 PM
Reception to follow
Hughes Auditorium, Lurie 1-133
303 E. Superior Street
For more information, please contact cdb@northwestern.edu.
Click here to subscribe to the CDB Seminar Series listserv.
May
29
CDB Trainee Seminar Series Presents: Adriana Landeros (Varma Lab) & Andrew Loiacono (Huang Lab)
Chicago - 12:00 PM - 1:00 PM
CDB Trainee Seminars Presents:
“Nuclear lamin A-associated proteins are required for centromere assembly"
Adriana Landeros
PhD Candidate, Varma Lab
12:00pm-12:30pm
“A protein critical for the perinucleolar compartment’s structure impacts tumor proliferation"
Andrew Loiacono
Research Technologist, Huang Lab
12:30pm-1:00pm
Refreshments to follow
1:00-2:00pm
Seminar: Wednesday, May 29, 2024
12:00-1:00pm
Simpson-Querrey Auditorium, SQ 1-230
Please contact cdb@northwestern.edu for more information or sign-up to our event listserv at https://www.feinberg.northwestern.edu/sites/cdb/about/listserv.html#listserv
May
31
Fulbright Research/Study/Arts Application Workshop
Evanston - 9:00 AM - 10:00 AM
Interested in pursuing research, study, or the arts abroad? Attend an application workshop to learn about the Fulbright application process at Northwestern. We will discuss application components and successful application strategies. You do not need a draft of your essays, but will benefit most if you have a clear vision of your project.
May
31
CDB Experts-in-the-field Seminar Series Presents: Jeremy Purvis, UNC School of Medicine
Chicago - 12:00 PM - 1:00 PM
CDB "EXPERTS-IN-THE-FIELD" SEMINAR PRESENTATION:
"Measuring, Modeling, and Targeting the Cell Cycle"
Jeremy Purvis, PhD
Professor
Department of Genetics
UNC School of Medicine
Chapel Hill, North Carolina
Friday, May 31, 2024
12:00–1:00 PM
Robert H Lurie Medical Research Center, Lurie 1-161
303 E. Superior St., Chicago
Host: Vipul Shukla
Assistant Professor
Department of Cell & Developmental Biology
Contact cdb@northwestern.edu for additional details or sign-up for our listserv at https://www.feinberg.northwestern.edu/sites/cdb/about/listserv.html#listserv
May
31
Neuroscience Seminar Series: Dr. Sama Ahmed
Chicago - 12:00 PM - 1:00 PM
Osama Ahmed, Ph.D., Assistant Professor and Weill Neurohub Term Assistant Professor
Bio
i am a weill neurohub term assistant professor in the department of psychology at the university of washington, seattle.
i completed my ph.d. training in neuroscience at ucsf and my postdoctoral tenure in the Murthy lab at the princeton neuroscience institute. my research interests span systems neuroscience, cognitive psychology, evolutionary biology, and genetics. currently, i am excited to delve deeper into the neurobiology of multitasking as a way to study how nervous systems generate and constrain different behaviors.
as a researcher, i am keen to practice science within alternate value systems that promote equity, safety, creativity, and imagination.
i acknowledge that the ahmed lab will operate on stolen Coast Salish land, on the ancestral lands of the Suquamish, Tulalip, and Muckleshoot Tribes. this acknowledgement is one way of resisting the erasure of indigenous histories and knowledge, and foregrounds our efforts to work differently in relationship to ourselves, each other, and the spaces wherein we work and live.
i am thankful to the BRAINS fellowship, the Burroughs Wellcome Fund, Weill NeuroHub, the Simons Collaboration on the Global Brain, and the UW for supporting our research.
May
31
Bacteriology journal club
Chicago - 2:00 PM - 3:00 PM
During bacteriology journal club, students and post-docs present their most recent research in progress or a bacteriology article of their choice
Jun
02
31st Annual Cancer Survivors' Celebration Walk & 5K
Off-Campus - 8:30 AM - 9:15 AM
For 31 years, Lurie Cancer Center’s Cancer Survivors’ Celebration Walk & 5K has been a source of hope and inspiration for people who have faced or are facing cancer. Held in Chicago’s Grant Park, our community event is a unique opportunity for cancer survivors, supporters, scientists and health professionals to connect, celebrate milestones, and make an impact on the future of cancer care.
We’re excited to run, walk and celebrate together on National Cancer Survivors Day! We strongly encourage you to register in advance. You must register by May 3 to receive your T-shirt before the event. If you register after May 3, you may pick up your T-shirt on the day of the event.
Highlights include:
- A non-competitive walk or chip-timed 5K race along the lakefront
- A commemorative T-shirt
- Music, entertainment, inspiring speakers and Dedication Wall
- Refreshments and activities for the family
Net proceeds and funds raised from our 31st annual event will help to advance groundbreaking cancer research and treatment at Robert H. Lurie Comprehensive Cancer Center of Northwestern University at Northwestern Memorial Hospital. We hope you will join the donors, sponsors and fundraising teams who support our efforts by creating a personalized fundraising page when you register. Fundraising is optional, and no minimum is required.
Jun
04
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
Jun
05
CDB Faculty Meeting
No Location - 12:00 PM - 1:00 PM
Cell & Developmental Biology Faculty Meeting.
Departmental faculty meet every first Wednesday from 12-1 PM. Calendar invites with the meeting location are disseminated in advance. Please contact cdb@northwestern.edu for more information.
Jun
07
Bacteriology journal club
Chicago - 2:00 PM - 3:00 PM
During bacteriology journal club, students and post-docs present their most recent research in progress or a bacteriology article of their choice
Jun
11
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
Jun
12
CDB Experts-in-the-field Seminar Series Presents: Kristy Red Horse, Stanford University
Chicago - 12:00 PM - 1:00 PM
CDB "EXPERTS-IN-THE-FIELD" SEMINAR PRESENTATION:
"Title TBD"
Kristy Red Horse, PhD
Associate Professor
Biology
Stanford University
Stanford, California
Wednesday, June 12, 2024
12:00–1:00 PM
Simpson-Querrey Auditorium, SQ 1-230
303 E. Superior St., Chicago
Host: Millie Romay & Eve Suva (Trainee Representatives)
Trainee Representatives
Department of Cell & Developmental Biology
Contact cdb@northwestern.edu for additional details or sign-up for our listserv at https://www.feinberg.northwestern.edu/sites/cdb/about/listserv.html#listserv
Jun
12
Lurie Cancer Center Symposium & Scientific Poster Session
Chicago - 2:00 PM - 6:30 PM
Please join us on Wednesday, June 12 for the Lurie Cancer Center Symposium to learn about groundbreaking research taking place in laboratories of Lurie Cancer Center members on Northwestern University's Evanston and Chicago campuses.
Jun
14
Bacteriology journal club
Chicago - 2:00 PM - 3:00 PM
During bacteriology journal club, students and post-docs present their most recent research in progress or a bacteriology article of their choice
Jun
18
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
Jun
19
CDB Faculty Seminar Presents: Richard Morimoto, PhD (Evanston Campus)
Chicago - 12:00 PM - 1:00 PM
CDB Faculty Seminars Presents:
"Title TBD"
Richard Morimoto, PhD
Professor
Department of Molecular Biosciences
Evanston, Northwestern
Wednesday, June 21, 2024
12:00–1:00 PM
Simpson Querrey Auditorium, SQ 1-230
Contact cdb@northwestern.edu for additional details or sign-up for our listserv at https://www.feinberg.northwestern.edu/sites/cdb/about/listserv.html#listserv
Jun
20
18th Annual Pain & Palliative Care Conference
Chicago - 8:00 AM - 3:30 PM
On Thursday, June 20, 2024, the 18th Annual Pain & Palliative Care Conference will bring together physicians, nurses, social workers, chaplains and healthcare professionals to share research and clinical best practices to advance the field of palliative care and improve care for patients with serious illnesses and their loved ones.
Jun
21
Neuroscience Seminar Series: Dr. Tina K Kim
Chicago - 12:00 PM - 1:00 PM
CHRISTINA K. KIM, PH.D., PRINCIPAL INVESTIGATOR, University of California, Davis
Assistant Professor | Center for Neuroscience, Department of Neurology
Affiliate Faculty | Genome Center, Center for Neuroengineering & Medicine
Background. Tina received her AB in Molecular Biology from Princeton University in 2011, and her Ph.D. in Neuroscience from Stanford University in 2017 with Karl Deisseroth. She completed her postdoctoral training with Alice Ting at Stanford in 2021.
Research interests. Functional and molecular profiling, protein engineering, technology development, systems neuroscience, motivated behaviors and decision making, in vivo imaging and manipulation of neural activity.
Jun
25
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
Jun
26
CDB Trainee Seminar Series Presents: Alicia Lin (Huang Lab) & Anwar Siddique (Hope Lab)
Chicago - 12:00 PM - 1:00 PM
CDB Trainee Seminars Presents:
“Title TBD"
Alicia Lin
Title, Huang Lab
Cell and Developmental Biology
“Title TBD"
Anwar Siddique
Graduate Student, Hope Lab
Cell and Developmental Biology
Refreshments to follow
1:00-2:00pm
Wednesday, June 26, 2024
12:00-1:00pm
Simpson-Querrey Auditorium, SQ 1-230
Please contact cdb@northwestern.edu for more information or sign-up to our event listserv at https://www.feinberg.northwestern.edu/sites/cdb/about/listserv.html#listserv
Jun
28
Bacteriology journal club
Chicago - 2:00 PM - 3:00 PM
During bacteriology journal club, students and post-docs present their most recent research in progress or a bacteriology article of their choice
Jul
02
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
Jul
09
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
Jul
12
Jul
16
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
Jul
23
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
Apr
30
Lurie Cancer Center Basic Research Seminar: Cancer Cell State and The Immune Microenvironment Coordinately Regulate Breast Cancer Metastasis
Chicago - 11:00 AM - 12:00 PM
The Lurie Cancer Center Basic Research Seminar presents:
Cancer Cell State and The Immune Microenvironment Coordinately Regulate Breast Cancer Metastasis
Andrew Ewald, PhD
Virginia DeAcetis Professor of Breast Cancer Research
Professor and Director, Department of Cell Biology
Professor of Oncology and Co-Director, Cancer Invastion and Metastasis Program
Sideny Kimmel Comprehensive Cancer Center
May
07
Lurie Cancer Center Basic Research Seminar: The Pathobiology of Myeloproliferative Neoplasms
Chicago - 11:00 AM - 12:00 PM
The Lurie Cancer Center Basic Research Seminar presents:
The Pathobiology of Myeloproliferative Neoplasms
Shannon Elf, PhD
Assistant Professor
Department of Internal Medicine
Division of Hematology and Hematologic Malignancies
University of Utah
May
14
Lurie Cancer Center Basic Research Seminar: TET-Mediated Epigenetic Regulation in Cancer and Aging
Chicago - 11:00 AM - 12:00 PM
The Lurie Cancer Center Basic Research Seminar presents:
TET-Mediated Epigenetic Regulation in Cancer and Aging
Yun Nancy Huang, PhD
Associate Professor
Center for Epigenetics and Disease Prevention
Institute of Biosciences & Technology
Texas A&M University
May
21
Lurie Cancer Center Basic Research Seminar: How Metabolism Informs the Epigenome
Chicago - 11:00 AM - 12:00 PM
The Lurie Cancer Center Basic Research Seminar presents:
How Metabolism Informs the Epigenome
John Denu, PhD
Wisconsin Institute for Discovery
Professor, Biomolecular Chemistry
School of Medicine and Public Health
University of Wisconsin - Madison
Apr
26
Precision Oncology: Beyond Mutations (2024 OncoSET Symposium)
Chicago - 8:00 AM - 3:30 PM
On Friday, April 26th, the OncoSET Symposium will provide healthcare professionals with state of the art information related to new advances in precision medicine looking beyond mutations in cancer treatment and care. The program will focus on improving the detection of fusions and their therapeutic vulnerabilities, enhancing future incorporation of multiomics assays into management decisions and discussing established and future molecular imaging targets. Participants will learn strategies for translating advances in precision medicine to their clinical practice.
Apr
26
FCVRRI Research in Progress - Maggie Fain
Chicago - 11:00 AM - 12:00 PM
Talk title - Exploring Cardiac-Renal Crosstalk in the Context of Sodium Glucose Cotransporter 2 Inhibitors
Apr
26
Fulbright Research/Study/Arts Application Workshop
Evanston - 12:00 PM - 1:00 PM
Interested in pursuing research, study, or the arts abroad? Attend an application workshop to learn about the Fulbright application process at Northwestern. We will discuss application components and successful application strategies. You do not need a draft of your essays, but will benefit most if you have a clear vision of your project.
Apr
26
Neuroscience Seminar Series: "Dendritic Spines: Old News, New Applications"
Chicago - 12:00 PM - 1:00 PM
Andrew Tan, Ph.D.
Assistant Professor, Department of Neurology, Yale University
Biography
My research interests focus on spinal cord injury (SCI) pathology, particularly mechanisms underlying neuropathic pain and spastic movement disorders. My long-term goal is to identify and assess novel targets and strategies that can help restore normal function after SCI. My hope is that our efforts will eventually lead to more effective and safe clinical therapies.
As the Principal Investigator (PI) of US Federal awards and privately funded grants, I have applied my expertise toward managing the execution of a broad range of projects, and have developed strong collaborations with domestic and international teams. As an Associate Director of the Center for Neuroscience and Regeneration Research at the West Haven VA Medical Center, I currently supervise a wonderful team of students, postdocs, and junior faculty in our SCI/D research program. Our published research has utilized in vitro and in vivo approaches, including a combination of anatomical analyses, behavioral assessment, viral-based gene therapy, and whole-animal electrophysiological techniques.
Over the past decade, my team has laid the groundwork demonstrating that maladaptive dendritic spine remodeling within nociceptive or motor reflex circuits underlies SCI-induced hyperexcitability disorders, i.e., neuropathic pain and spasticity. This body of work has also demonstrated for the first time that the Rac1-PAK1 pathway is a key mechanism involved in maintaining chronic pain and spinal motor reflex dysfunction. A core implication of these insights is that dendritic spine profiles may serve as a morphological correlate for sensory-motor hyperexcitability disorders, and could be used to predict therapeutic-drug response. Recently, we pioneered the use of long-term, in vivo two-photon imaging assays that we now use to investigate the relationship between dendritic spine dynamics in the spinal dorsal horn and neuropathic pain.
Apr
26
Searle Center Graduate Student Programs Info Session
Evanston - 1:00 PM - 3:00 PM
Looking to branch out as a teacher? Join us at our upcoming Graduate Student Programs Info Session!
Graduate students are invted to learn about Searle's Programs from current participants and Searle staff. You will have the opportunity to mingle, ask questions ,and learn more about how the Searle Center can support your pedagogical development. Food and drinks will be available!
Representatives from the following programs will be present:
- Reflective & Effective Teaching
Applications and registration for the 2024-2025 academic year are open until Monday, May 20, 2024!
Apr
26
Bacteriology journal club
Chicago - 2:00 PM - 3:00 PM
During bacteriology journal club, students and post-docs present their most recent research in progress or a bacteriology article of their choice
Apr
29
Providing Effective Feedback to Students: STEM and Social Sciences Perspectives
Evanston - 12:00 PM - 1:30 PM
During this workshop, participants will consider different methods of providing effective feedback on a variety of student assignments, from homework and exams to lab reports and essays. We will discuss strategies for providing detailed, specific feedback that allow students to focus on how to improve instead of focusing on mistakes made. Participants will practice providing feedback on mock assignments. We will also explore how to navigate difficult or emotional discussions with students about grades.
Facilitated by Graduate Teaching Fellows:
Gerpha Gerlin, Anthropology PhD Candidate
Clover Moisanu, Chemistry PhD Candidate
Apr
29
Lurie Cancer Center Research-In-Progress Seminar Series
Chicago - 1:00 PM - 2:00 PM
Leveraging NKG2D Signaling through Anti-MIC Immunotherapy
to Promote Intratumoral CD8 T cell Stemness
Tyler Smith, PhD
Postdoctoral Fellow (J. Wu Lab)
Northwestern University Feinberg School of
Medicine
Lunch will be provided.
All members of the Northwestern
Medicine community are welcome to
attend
Apr
29
Pharmacology Faculty Candidate | Steffen Lindert, PhD Using Computers to Derive Protein Structure from Sparse Data – A Case Study for Mass Spectrometry"
Chicago - 3:00 PM - 4:00 PM
Title: "Using Computers to Derive Protein Structure from Sparse Data – A Case Study for Mass Spectrometry."
Abstract: Mass spectrometry-based methods such as covalent labeling, surface induced dissociation (SID) or ion mobility (IM) are increasingly used to obtain information about protein structure. However, in contrast to other high-resolution structure determination methods, this information is not sufficient to deduce all atom coordinates and can only inform on certain elements of structure, such as solvent exposure of individual residues, properties of protein-protein interfaces or protein shape. Computational methods are needed to predict high-resolution protein structures from the mass spectrometry (MS) data. Our group develops algorithms within the Rosetta software package that use mass spectrometry data to guide protein structure prediction. These algorithms can incorporate several different types of mass spectrometry data, such as covalent labeling, surface induced dissociation, and ion mobility. We developed scoring functions that assess the agreement of residue exposure with covalent labeling data, the agreement of protein-protein interface energies with SID data and the agreement of protein model shapes with collision cross section (CCS) IM measurements. We subsequently rescored Rosetta models generated with de novo protein folding and protein-protein docking and we were able to accurately predict protein structure from MS labeling, SID and IM data. Future work is focusing on developing custom machine learning models to predict protein structure from MS data.
Steffen Lindert, PhD, Associate Professor of Chemistry and Biochemistry.
Bio: Steffen Lindert received his M.Sc. in Physics from the University of Leipzig in 2006 and his Ph.D. in Chemical and Physical Biology (Molecular Biophysics track) from Vanderbilt University in 2011. Co- advised by Prof. Jens Meiler and Prof. Phoebe Stewart, he worked on a combined experimental and computational project developing a program – EM-Fold – which folds proteins into medium resolution cryoEM density maps. After finishing his Ph.D., he joined the laboratory of Prof. Andy McCammon at the University of California, San Diego, as a postdoctoral fellow. His research focused on macromolecular simulations of proteins involved in cardiomyocyte contraction and computer-aided drug discovery. He was awarded a prestigious postdoctoral fellowship from the American Heart Association. He started his research group at OSU in August of 2015. Research in the lab focuses on the development and application of computational techniques for modeling biological systems, with the goal of gaining a deeper understanding of biomolecular processes, predicting protein structure de novo with the use of sparse experimental data, and discovering new drugs.
Apr
29
Fulbright English Teaching Assistantships Information Session
Evanston - 4:00 PM - 5:00 PM
Are you interested in teaching English abroad after graduation? The U.S. Department of State’s Fulbright U.S. Student Program places English Teaching Assistants (ETAs) in classrooms abroad to provide support to local English teachers. ETAs strengthen English language instruction in seventy-five countries world-wide while serving as cultural ambassadors of the United States. Host institutions range from elementary and secondary schools to university-level language departments. Stop by the info session to meet the campus contact and learn more.
Apr
30
CDB Experts-in-the-field Seminar Series Presents: Sun Hur, Harvard University
Chicago - 9:30 AM - 10:30 AM
CDB "EXPERTS-IN-THE-FIELD" SEMINAR PRESENTATION:
"Nucleic acid-driven self-assemblies: transcriptional regulation and beyond"
Sun Hur, Ph.D.
Professor of Biological Chemistry and Molecular Pharmacology
Oscar M. Schloss, MD Professor of Pediatrics
Harvard University
Boston, Massachusetts
Wednesday, April 30, 2024
9:30–10:30 AM
Baldwin Auditorium, Lurie 1-123
303 E. Superior St., Chicago
Host: Dr. Vipul Shukla
Assistant Professor
Department of Cell & Developmental Biology
The department hosts guest lectures every second Wednesday from 12-1 PM. Calendar invites are disseminated in advance with event details. Contact cdb@northwestern.edu for additional details or sign-up for our listserv at https://www.feinberg.northwestern.edu/sites/cdb/about/listserv.html#listserv
Apr
30
DGP Student Thesis Seminar - Sakshi Khurana - Daniel Foltz Lab
Chicago - 11:00 AM - 12:00 PM
Title of Presentation:
"Non-Canonical Functions of CENP-F in Chromosomal and Genomic Instability"
This is a hybrid event. For Zoom access or more information, email rachael.hill@northwestern.edu.
Apr
30
Lurie Cancer Center Basic Research Seminar: Cancer Cell State and The Immune Microenvironment Coordinately Regulate Breast Cancer Metastasis
Chicago - 11:00 AM - 12:00 PM
The Lurie Cancer Center Basic Research Seminar presents:
Cancer Cell State and The Immune Microenvironment Coordinately Regulate Breast Cancer Metastasis
Andrew Ewald, PhD
Virginia DeAcetis Professor of Breast Cancer Research
Professor and Director, Department of Cell Biology
Professor of Oncology and Co-Director, Cancer Invastion and Metastasis Program
Sideny Kimmel Comprehensive Cancer Center
Apr
30
M-I Dept. Seminar / Inhibition of Kaposi’s Sarcoma Associated Herpesvirus microRNAs in Primary Effusion Lymphoma
Chicago - 12:00 PM - 1:00 PM
Seminar Title:
Inhibition of Kaposi’s Sarcoma Associated Herpesvirus microRNAs in Primary Effusion Lymphoma
Speaker: Jesus Ortega, Graduate Student, Driskill Graduate Program
Topic:
Kaposi's Sarcoma Herpesvirus (KSHV) causes several human cancers, including the non-Hodgkin’s body cavity primary effusion lymphoma (PEL). In PEL, KSHV remains latent, expressing few proteins and several viral microRNAs (miRNAs). To date, specific challenges with KSHV biology have precluded effective viral miRNA loss-of-function studies. By exploring new mechanistic insights into miRNA turnover, I achieve robust miRNA inhibition, highlighting the essentiality of a viral miRNA mimic of miR-155 in sustaining viability and proliferation of patient-derived PEL.
Host: Dr. Eva Gottwein, Associate Professor, Dept. of Microbiology-Immunology
Apr
30
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
Apr
30
Pharmacology Seminar Series | Christopher Burge, PhD "Interpretable models to understand regulation of RNA splicing"
Chicago - 3:00 PM - 4:00 PM
Title: "Interpretable models to understand regulation of RNA splicing."
Abstract: Burge lab is developing fully interpretable models of RNA splicing and its regulation for improved understanding and various applications. They have developed a model of regulation from in vitro RNA binding data and splicing factor knockdown experiments called KATMAP that predicts precise patterns of activity, distinguishes direct from indirect effects, and detects cooperative activity. He will also discuss our findings that proteins of the Luc7 family recognize two distinct subclasses of 5’ splice sites, with implications leukemia, metabolic regulation and the evolution of introns.
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Christopher Burge, PhD, CSB Program Director; Professor of Biology; Extramural Member of KIICR; Associate Member of the Broad Institute, Massachusetts Institute of Technology.
May
01
CDB Faculty Meeting
No Location - 12:00 PM - 1:00 PM
Cell & Developmental Biology Faculty Meeting.
Departmental faculty meet every first Wednesday from 12-1 PM. Calendar invites with the meeting location are disseminated in advance. Please contact cdb@northwestern.edu for more information.
May
02
Fulbright English Teaching Assistantships Information Session
Evanston - 9:00 AM - 10:00 AM
Are you interested in teaching English abroad after graduation? The U.S. Department of State’s Fulbright U.S. Student Program places English Teaching Assistants (ETAs) in classrooms abroad to provide support to local English teachers. ETAs strengthen English language instruction in seventy-five countries world-wide while serving as cultural ambassadors of the United States. Host institutions range from elementary and secondary schools to university-level language departments. Stop by the info session to meet the campus contact and learn more.
May
02
BMG Seminar: Kapil Bhalla, MD, University of Texas MD Anderson Cancer Center, Houston, TX
Chicago - 10:00 AM - 11:00 AM
The Department of Biochemistry and Molecular Genetics presents:
Kapil Bhalla, MD
Professor, Department of Leukemia, Division of Cancer Medicine and Kelcie Kana Research Chair
University of Texas MD Anderson Cancer Center
Presentation:
"Pre-clinical efficacy of targeted inhibition of Chromatin remodeler ATPases in models of high-risk AML"
Abstract: BRG1 (SMARCA4) and BRM (SMARCA2) are the core ATPase within the multi-protein, ATP-dependent, chromatin remodeling BAF complexes that regulate gene transcription. FHD-286 is a potent, selective, orally administered, inhibitor of BRG1/BRM in early clinical development as a therapy for AML. This presentation will describe the pre-clinical in vitro and in vivo efficacy FHD-286 in models of high-risk AML. Treatment with FHD-286 for 4 to 7 days induced morphologic features of differentiation and loss of viability in AML cell lines and patient-derived (PD) AML cells with MLLr or mtNPM1. Notably, FHD-286 also induced significant lethality in Menin inhibitor (MI) resistant AML cell lines and PD AML cells lacking Menin mutations. ChIP-Seq, ATAC-Seq, RNA-Seq, Mass spectrometry and CyTOF analyses data will be presented to define gene-expressions alterations that correlate with the lethal effects of FHD-286. Findings from a domain-specific CRISPR screen targeting epigenetic regulators revealed significant co-enrichments with FHD-286 treatment of the gRNAs against BRD4 and LSD1, suggesting them as the epigenetic mediators of FHD-286 resistance. Co-treatment with FHD-286 and venetoclax, BET inhibitor, decitabine or MI (SNDX-50469) exerted synergistic lethality in AML cell lines and PD AML cells with MLL1r or mtNPM1. In a PD xenograft (PDX) model of MLL1r AML with FLT3 mutation, monotherapy with FHD-286 for 4 to 6-weeks was significantly effective in reducing AML burden and improving overall survival. Separately, in vivo FHD-286 treatment vs vehicle control, also significantly inhibited the AML-initiating potential of AML stem progenitor cells. Additionally, co-treatment with FHD-286 and decitabine or BET inhibitor vs each drug alone, or vehicle control, significantly reduced the AML burden and improved survival, without significant toxicity in the PDX models of MLLr or mtNPM1, as well as of MECOM rearranged AML. Finally, co-treatment with FHD-286 and MI was significantly more effective than each drug alone in reducing the AML burden and overall survival of mice engrafted with a separate PDX model of AML cells with mtNPM1 and FLT3-ITD, without significant toxicity. These findings demonstrate the pre-clinical efficacy of FHD-286-based rational combinations and support their clinical testing in the high-risk AML models.
Host: Dr. Lu Wang, Assistant Professor, Biochemistry and Molecular Genetics
May
02
James C. Houk Lecture in Motor Control: "Executing, Reinforcing and Refining Actions" with Rui Costa, DVM, PhD
Chicago - 2:00 PM - 3:30 PM
The Department of Neuroscience Presents:
The James C. Houk Lecture in Motor Control: "Executing, Reinforcing and Refining Actions"
Rui Costa, DVM, PhD
President and CEO
Allen Institute
Professor of Neuroscience
Columbia University
Abstract
The ability of animals to build individual repertoires based on the consequences of their actions is fascinating, and essential for survival. Understanding this process, i.e., how actions are learned through trial and feedback, requires mechanistic insight into how self-paced actions are initiated, how they can be selected/initiated again, and how feedback can refine their execution and organization. We use behavioral, genetic, electrophysiological, and optical approaches to gain this mechanistic insight. The combination of these approaches allowed us to uncover that dopaminergic neurons are transiently active before self-paced movement initiation. This activity is not action-specific and modulates both the probability of initiation and the vigor of future movements, but does not affect ongoing movement. Dopamine is supposed to have opposite effects on downstream striatal direct and indirect pathways. Contrary to what is classically postulated, we found that both striatal direct and indirect pathways are active during movement initiation. The activity in both pathways is action-specific and has complementary but different roles in movement, which are enabled by specific basal ganglia output circuits. Input from cortex seems to be critical to organize striatal activity, and cortico-striatal plasticity is necessary to select, reinforce and refine the specific neural and behavioral patterns that lead to desirable outcomes. These data invite new models on the mechanisms underlying self-paced movement initiation, and motor dysfunction in Parkinson’s disease. They also suggest that cortico-basal ganglia circuits play a generic role in learning to reinforce and refine task-relevant neural activity and behavioral patterns.
About Dr. Costa
Rui Costa is a neuroscientist and the current president and CEO of the Allen Institute. His laboratory develops and uses genetic, electrophysiological, optical, and behavioral approaches to investigate how the brain adaptively controls behavior and internal organ function. He did his PhD studies with Dr. Alcino Silva at UCLA and postdoctoral work with Dr. Miguel Nicolelis at Duke University. He then became section chief at the National Institutes of Health, an investigator of the Champalimaud Neuroscience Program, and a professor at Columbia University. He was co-director of Champalimaud Research and director/CEO of the Zuckerman Mind Brain Behavior Institute at Columbia University. He received several awards, such as the Young Investigator Award from SFN, the Ariëns Kappers Medal from the Royal Netherlands Academy of Arts and Sciences, and the Mina Bissell Award, and was knighted Commander of the Order of Sant'Iago da Espada by the President of Portugal. He is an elected member of EMBO, and the National Academy of Medicine.
About the James C. Houk Lecture in Motor Control
In 2020, the late James C. Houk, PhD, and his wife Antoinette made a bequest to establish the Dr. James Houk Graduate Fellowship in Neuroscience. Their gift provides funding to outstanding graduate students studying neurophysiology at Northwestern and supports the annual James C. Houk Lecture in Motor Control, presented by a renowned motor neuroscientist.
About James C. Houk, PhD
Dr. James C. Houk originally studied electrical engineering before receiving his PhD in physiology at Harvard University. As an assistant professor at Harvard, he studied Golgi tendon organs, muscle spindles and developed control models of muscle activation through neuronal circuits in the spinal cord.
Later, as an associate professor at Johns Hopkins Medical School, Houk began work on the central nervous system in behaving monkeys, work he continued at Northwestern University, after being recruited in 1978 as chair of the Department of Physiology (now Neuroscience). During this time, Houk also built a world-renowned systems neuroscience group within the department.
In 2001, after 23 years, Houk stepped down as chair to concentrate on multimodal approaches to studying how the nonlinear dynamics of microscopic modules in the brain give rise to its unique computational properties. He became particularly interested in the interplay between the basal ganglia, motor cortex and cerebellum.
May
03
Translational Research in Malignancies Symposium
Chicago - 8:00 AM - 12:15 PM
On Friday, May 3, 2024, the Robert H. Lurie Comprehensive Cancer Center of Northwestern University will host the Translational Research in Malignancies Symposium on the Chicago campus of Northwestern University. The focus of the program is "Resistance to Cancer Treatment".
Chairs:
Dr. Daniela Matei, MD
Dr. Roger Stupp, MD
Dr. Lucy Godley, MD, PhD
Lurie Cancer Center
Featured Speakers:
Ranjit Bindra, MD, PhD
Yale School of MedicineAlfred Zippelius, MD
University Hospital Basel
Atique Ahmed, PhD
Jaehyuk Choi, MD, PhD
Yogesh Goyal, PhD
Lurie Cancer Center
May
03
Sparkshop: Strengths-Based Strategies for Neurodiverse Students
Online - 11:00 AM - 11:30 AM
Based in the principles of Universal Design for Learning, this 30-minute virtual presentation offers evidence-driven teaching strategies to support neurodivergent student success at a broad level, breaking down barriers and building in choice to empower students to utilize and develop their own academic strengths.
May
03
Fulbright Research/Study/Arts Application Workshop
Evanston - 12:00 PM - 1:00 PM
Interested in pursuing research, study, or the arts abroad? Attend an application workshop to learn about the Fulbright application process at Northwestern. We will discuss application components and successful application strategies. You do not need a draft of your essays, but will benefit most if you have a clear vision of your project.
May
03
BMG Journal Club
Chicago - 1:00 PM - 2:00 PM
The BMG Journal Club is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience.
Refreshments will be provided.
May
03
Bacteriology journal club
Chicago - 2:00 PM - 3:00 PM
During bacteriology journal club, students and post-docs present their most recent research in progress or a bacteriology article of their choice
May
03
DGP Student Thesis Seminar - Carolyn Lorch - Lisa Beutler Lab
Chicago - 2:00 PM - 4:00 PM
Title of Presentation:
"Sucrose overconsumption impairs AgRP neuron dynamics and promotes palatable food intake"
This is a hybrid event. For Zoom access or more information, email rachael.hill@northwestern.edu.
May
06
Fulbright English Teaching Assistantships Information Session
Evanston - 12:00 PM - 1:00 PM
Are you interested in teaching English abroad after graduation? The U.S. Department of State’s Fulbright U.S. Student Program places English Teaching Assistants (ETAs) in classrooms abroad to provide support to local English teachers. ETAs strengthen English language instruction in seventy-five countries world-wide while serving as cultural ambassadors of the United States. Host institutions range from elementary and secondary schools to university-level language departments. Stop by the info session to meet the campus contact and learn more.
May
07
Lurie Cancer Center Basic Research Seminar: The Pathobiology of Myeloproliferative Neoplasms
Chicago - 11:00 AM - 12:00 PM
The Lurie Cancer Center Basic Research Seminar presents:
The Pathobiology of Myeloproliferative Neoplasms
Shannon Elf, PhD
Assistant Professor
Department of Internal Medicine
Division of Hematology and Hematologic Malignancies
University of Utah
May
07
M-I Dept. Seminar / Visualizing Host-Virus Interactions at High Resolutions In Situ
Chicago - 12:00 PM - 1:00 PM
Title: Visualizing Host-Virus Interactions at High Resolutions In Situ
Speaker:
Yong Xiong, PhD, Professor, Yale School of Medicine, Dept. of Molecular Biophysics and Biochemistry
Topic:
Obtaining comprehensive structural descriptions of viruses and macromolecules within the natural cellular context holds immense potential for understanding fundamental biology and improving health. Here, we present the recent advances in in situ single-particle cryo-electron microscopy (cryo-EM), which allows us to view how HIV-1 capsids interact with antiviral compounds within the actual environment of the virus, as well as providing a detailed view of protein synthesis within human cells.
Host: Mojgan Naghavi, PhD, Professor, Dept. of Microbiology-Immunology
May
07
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
May
07
Fulbright Research/Study/Arts Application Workshop
Online - 7:00 PM - 8:00 PM
Interested in pursuing research, study, or the arts abroad? Attend an application workshop to learn about the Fulbright application process at Northwestern. We will discuss application components and successful application strategies. You do not need a draft of your essays, but will benefit most if you have a clear vision of your project.
May
08
Pharmacology Faculty Candidate: Smriti Sangwan, PhD "Molecular Mechanisms of Translational Regulation"
Chicago - 11:00 AM - 12:00 PM
Title: Molecular Mechanisms of Translational Regulation".
Abstrac: Sangwan is a structural biologist broadly interested in the signaling systems that ensure protein homeostasis. Defects in protein homeostasis are linked to disease conditions such as neurodegenerative diseases and cancer; however, our understanding of how these pathways organize in cells is limited due to their inherently transient nature. Sangwan will summarize her recent work on two proteins that are involved in protein quality control and are recruited to the translation machinery. One protein called eIF2A facilitates the translation of stress-response genes under conditions of cellular stress. Another protein called IRE1 monitors protein folding status and activates a transcription response upon protein misfolding stress, She utilized single-particle cryoEM, biochemical assays and next-generation sequencing to decipher their mechanism of action. Her work sets the stage for targeted drug design of these two proteins which play critical roles in various forms of cancer, infectious diseases, and protein misfolding disorders.
Smriti Sangwan, PhD; Post-Doctoral Fellow int he lab of Peter Walter, PhD; University of California, San Francisco
May
08
CDB Experts-in-the-field Seminar Series Presents: Cigall Kadoch, Dana-Farber Cancer Institute and Harvard Medical School
Chicago - 12:00 PM - 1:00 PM
CDB "EXPERTS-IN-THE-FIELD" SEMINAR PRESENTATION:
"Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Health and Disease"
Cigall Kadoch, PhD
Associate Professor
Department of Pediatric Oncology
Dana-Farber Cancer Institute and Harvard Medical School
Boston, Massachusetts
Wednesday, May 8, 2024
12:00–1:00 PM
Simpson-Querrey Auditorium, SQ 1-230
303 E. Superior St., Chicago
Host: Vipul Shukla
Assistant Professor
Department of Cell & Developmental Biology
Contact cdb@northwestern.edu for additional details or sign-up for our listserv at https://www.feinberg.northwestern.edu/sites/cdb/about/listserv.html#listserv
May
09
BMG Seminar: Scott B Rothbart, PhD, Van Andel Institute, Grand Rapids, MI
Chicago - 10:00 AM - 11:00 AM
The Department of Biochemistry & Molecular Genetics presents:
Scott B Rothbart, PhD
Professor, Department of Epigenetics
Co-Director, NCI T32 Cancer Epigenetics Training Program
Van Andel Institute, Grand Rapids, MI
Presentation:
"Mechanisms and therapeutic targeting of chromatin modification crosstalk"
Abstract:
My lab studies basic cellular and molecular mechanisms regulating chromatin accessibility, interaction, and function. We are particularly interested in the interconnected molecular activities of proteins that write, erase, and read histone post-translational modifications (PTMs) and DNA methylation, and we seek to understand roles for these chromatin modifications in the regulation of transcription, DNA replication, chromatin organization, and the preservation of cell identity. Our studies are facilitated by the development and improvement of tools and technologies for the field. As chromatin modifiers and associated proteins are frequently mutated and dysregulated in human diseases, most notably cancer, our studies are also revealing pathological mechanisms associated with chromatin dysregulation, identifying new targets for drug discovery, and providing mechanistic rationale for multi-targeted therapeutic approaches to improve patient outcomes. Direct translation of our findings to clinical trials is facilitated by an Epigenetic Therapies NCI SPORE grant (the second discipline-based SPORE awarded) and the Van Andel Institute-Stand Up to Cancer Epigenetics Dream Team, where I participate as a Basic Science Investigator.
Host: Dr. Shannon Lauberth, Associate Professor of Biochemistry and Molecular Genetics
May
09
Games as a Tool for Active Learning
Evanston - 1:00 PM - 2:00 PM
Using interactive activities in the classroom can can help students engage with core concepts and topics in almost any subject and discipline. Games are one example of an interactive activity that can enable students to explore and engage with lessons. In this workshop, we will discuss the use of games as a tool for active learning. Participants will have the opportunity to explore ways they can incorporate games into their lectures and discussion sections.
Facilitated by Jennifer Lin, PhD candidate in Political Science
May
10
FCVRRI Series Seminar - Matthew Feinstein, MD
Chicago - 11:00 AM - 12:00 PM
Talk title: Cardiovascular Inflammation in (reverse) Translation: Insights from the Bedside
May
10
Neuroscience Seminar Series: "Feeling the Force: PIEZO ion channels in interoception"
Chicago - 12:00 PM - 1:00 PM
Kara Marshall, Ph.D - Assistant Professor, Baylor College of Medicine, Howard Hughes Medical Institute
Abstract
Our organs move, stretch, and contract during their every day function, and the nervous system detects these mechanical cues to drive physiology. PIEZO ion channels are mechanical force sensors, and we are unraveling their role in the physiology of the urinary and gastrointestinal tract and behavior.
May
10
Bacteriology journal club
Chicago - 2:00 PM - 3:00 PM
During bacteriology journal club, students and post-docs present their most recent research in progress or a bacteriology article of their choice
May
10
Joint Lurie Cancer Center Breast Cancer Research Program (BCRP) Seminar Series
Chicago - 3:00 PM - 4:00 PM
A new seminar series highlighting current multi-disciplinary cancer research at the Lurie Cancer Center
“The role of the death receptor Fas in breast cancer”
Marcus Peter, PhD
Professor
Medicine-Hematology Oncology Division
Northwestern University
Feinberg School of Medicine
“Investigating Environmental Risk Factors for Breast Cancer Using HSA-Cys34 Adductomics in the Sister Study”
William Funk, PhD
Associate Professor
Preventative Medicine-Cancer Epidemiology and Prevention
Northwestern University
Feinberg School of Medicine
Refreshments will be provided
May
13
Fulbright Research/Study/Arts Application Workshop
Evanston - 12:00 PM - 1:00 PM
Interested in pursuing research, study, or the arts abroad? Attend an application workshop to learn about the Fulbright application process at Northwestern. We will discuss application components and successful application strategies. You do not need a draft of your essays, but will benefit most if you have a clear vision of your project.
May
13
Lurie Cancer Center Core Technologies & Applications Seminar Series
Chicago - 1:00 PM - 2:00 PM
“Empowering Cancer Research and Drug Discovery with
High Throughput Technologies”
An Introduction to High Throughput Analysis Core at Northwestern University
Sara Fernandez Dunne, MS
Manager, High Throughput Analysis Lab
Northwestern University Feinberg School of Medicine
The Binding-centric Paradigm by Wet-lab and in Silico Screening
Chi-Hao Luan, PhD
Scientific Director, High Throughput Analysis Lab
Research Professor of Molecular Biosciences
Northwestern University Feinberg School of Medicine
Lunch is provided
May
13
Pharmacology Seminar Series | Teru Nakagawa, PhD "Structure and function of AMPA receptor auxiliary subunit complexes"
Chicago - 3:00 PM - 4:00 PM
Title: "Structure and function of AMPA receptor auxiliary subunit complexes"
Abstract: Functional modulation of excitatory synaptic transmission in mammalian brain is fundamental to information processing across neurons, while dysfunctions of synapses accompany various neurological and psychiatric disorders. AMPA-type ionotropic glutamate receptors (AMPA-Rs) are ligand-gated ion channels activated by neurotransmitter L-glutamate and mediate most of excitatory synaptic transmission in the central synapses. Our current focus is to uncover fundamental mechanisms that underly the gating and trafficking of AMPA-Rs, taking approaches in structural biology, biochemistry, cell biology, and electrophysiology. These efforts may lead to producing knowledge relevant to designing new therapeutics that could control synaptic activities under disease conditions, which include Alzheimer’s disease, intellectual disability, seizure, excitotoxicity, ALS, memory loss, addiction, schizophrenia, and autism. In this seminar I will present recent progress we made in our laboratory on the molecular structures of AMPA-R in complex with auxiliary subunits and their ion permeation mechanisms.
Teru Nakagawa, PhD
Professor, Department of Molecular Physiology and Biophysics, Center for Structural Biology, Vanderbilt Brain Institute
May
14
Lurie Cancer Center Basic Research Seminar: TET-Mediated Epigenetic Regulation in Cancer and Aging
Chicago - 11:00 AM - 12:00 PM
The Lurie Cancer Center Basic Research Seminar presents:
TET-Mediated Epigenetic Regulation in Cancer and Aging
Yun Nancy Huang, PhD
Associate Professor
Center for Epigenetics and Disease Prevention
Institute of Biosciences & Technology
Texas A&M University
May
14
M-I Dept. Seminar / Multidimensional Bacterial Profiles to Uncover Pathways to Resistance and Host-Immune Interactions
Chicago - 12:00 PM - 1:00 PM
Title:
Multidimensional Bacterial Profiles to Uncover Pathways to Resistance and Host-Immune Interactions
Speaker:
Tim van Opijnen, Ph.D
Boston Children’s Hospital
Division of Infectious Diseases
Associate Professor of Pediatrics
Harvard Medical School
Broad Institute of MIT
Topic:
Although vaccines and antibiotics have been historically successful in combating bacterial infections, limited vaccine coverage and the rise of antibiotic resistance emphasize the need to design new targeted treatment strategies. In an attempt to answer this call, we are developing platform technology that combines data from approaches including single cell, bulk and dualRNA-Seq, Tn-Seq, and CRISPRi into multidimensional bacterial profiles, that can be computationally mined to aid in developing drug and/or immune-enhancing approaches.
Host:
Bacteriology Graduate Students and Postdocs, coordinated by Graduate Student Marine LeBrun
May
14
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
May
14
Fulbright English Teaching Assistantships Information Session
Evanston - 4:00 PM - 5:00 PM
Are you interested in teaching English abroad after graduation? The U.S. Department of State’s Fulbright U.S. Student Program places English Teaching Assistants (ETAs) in classrooms abroad to provide support to local English teachers. ETAs strengthen English language instruction in seventy-five countries world-wide while serving as cultural ambassadors of the United States. Host institutions range from elementary and secondary schools to university-level language departments. Stop by the info session to meet the campus contact and learn more.
May
15
CDB Faculty Seminar Presents: Christian Petersen, PhD (Evanston Campus)
Chicago - 12:00 PM - 1:00 PM
CDB Faculty Seminars Presents:
"Regulation of whole-body regenerative ability in animals"
Christian Petersen, PhD
Professor
Department of Molecular Biosciences
Evanston, Northwestern
Wednesday, May 15, 2024
12:00–1:00 PM
Simpson Querrey Auditorium, SQ 1-230
Contact cdb@northwestern.edu for additional details or sign-up for our listserv at https://www.feinberg.northwestern.edu/sites/cdb/about/listserv.html#listserv
May
17
Neuroscience Seminar Series: "Neural circuit mechanisms of value-based decision-making"
Chicago - 12:00 PM - 1:00 PM
Christine Constantinople, Ph.D.
Assistant Professor, Center for Neural Science
New York University
Abstract:
The value of the environment determines animals’ motivational states and sets expectations for error-based learning. But how are values computed? We developed a novel temporal wagering task with latent structure, and used high-throughput behavioral training to obtain well-powered behavioral datasets from hundreds of rats that learned the structure of the task. We found that rats use distinct value computations for sequential decisions within single trials. Moreover, these sequential decisions are supported by different brain regions, suggesting that distinct neural circuits support specific types of value computations. I will discuss our ongoing efforts to delineate how distributed circuits in the orbitofrontal cortex and striatum coordinate complex value-based decisions.
May
17
BMG Journal Club
Chicago - 1:00 PM - 2:00 PM
The BMG Journal Club is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience.
Refreshments will be provided.
May
17
Bacteriology journal club
Chicago - 2:00 PM - 3:00 PM
During bacteriology journal club, students and post-docs present their most recent research in progress or a bacteriology article of their choice
May
20
CDB Experts-in-the-field Seminar Series Presents: Krishna Shrinivas, Northwestern University
Chicago - 10:00 AM - 11:00 AM
CDB "EXPERTS-IN-THE-FIELD" SEMINAR PRESENTATION:
"Gene regulation and nuclear organization by biomolecular condensates"
Krishna Shrinivas, PhD
Assistant Professor
Department of Chemical and Biological Engineering
Northwestern University
Evanston Campus
Monday, May 20, 2024
10:00–11:00 AM
Simpson-Querrey Auditorium, SQ 1-230
303 E. Superior St., Chicago
Host: Vipul Shukla
Assistant Professor
Department of Cell & Developmental Biology
Contact cdb@northwestern.edu for additional details or sign-up for our listserv at https://www.feinberg.northwestern.edu/sites/cdb/about/listserv.html#listserv
May
20
Pharmacology Seminar Series | Axel Concepcion, PhD
Chicago - 3:00 PM - 4:00 PM
Axel Concepcion, PhD
Neubauer Family Assistant Professor of Biochemistry and Molecular Biology
Committee on Immunology
Research and Scholarly Interests: Biochemistry, Cell Signaling, Ion Transport, Molecular Immunology, Mouse Models, T Cells
May
21
M-I Dept. Seminar / Targeting Tuberculosis Adaptive (Mis)Translation as an Anti-Virulence Strategy
Chicago - 10:00 AM - 11:00 AM
Title: Targeting Tuberculosis Adaptive (Mis)Translation as an Anti-Virulence Strategy
Speaker: Babak Javid, PhD, Associate Professor, Division of Experimental Medicine, UCSF
Topic:
Rather than purely performing essential housekeeping functions, regulation of the protein synthesis machinery in bacterial pathogens contributes to critical adaptive functions. I will discuss how regulation of the stochastic error rate in protein synthesis in mycobacteria contributes to both antibiotic and host tolerance and potential ways to target this conserved pathway.
Host: M.-N. Frances Yap, PhD, Associate Professor, Dept. of Microbiology-Immunology
May
21
Lurie Cancer Center Basic Research Seminar: How Metabolism Informs the Epigenome
Chicago - 11:00 AM - 12:00 PM
The Lurie Cancer Center Basic Research Seminar presents:
How Metabolism Informs the Epigenome
John Denu, PhD
Wisconsin Institute for Discovery
Professor, Biomolecular Chemistry
School of Medicine and Public Health
University of Wisconsin - Madison
May
21
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
May
22
CANCELLED - CDB Faculty Seminar Presents: Yevgenia Kozorovitskiy, PhD (Evanston Campus)
Chicago - 12:00 PM - 1:00 PM
CDB Faculty Seminars Presents:
"Title TBD"
Yevgenia Kozorovitskiy, PhD
Associate Professor
Department of Neurobiology
Soretta and Henry Shapiro Professor of Molecular Biology
Evanston, Northwestern
Wednesday, May 22, 2024
12:00–1:00 PM
Simpson Querrey Auditorium, SQ 1-230
Contact cdb@northwestern.edu for additional details or sign-up for our listserv at https://www.feinberg.northwestern.edu/sites/cdb/about/listserv.html#listserv
May
22
Fulbright English Teaching Assistantships Information Session
Evanston - 12:00 PM - 1:00 PM
Are you interested in teaching English abroad after graduation? The U.S. Department of State’s Fulbright U.S. Student Program places English Teaching Assistants (ETAs) in classrooms abroad to provide support to local English teachers. ETAs strengthen English language instruction in seventy-five countries world-wide while serving as cultural ambassadors of the United States. Host institutions range from elementary and secondary schools to university-level language departments. Stop by the info session to meet the campus contact and learn more.
May
23
Fulbright Research/Study/Arts Application Workshop
Online - 9:00 AM - 10:00 AM
Interested in pursuing research, study, or the arts abroad? Attend an application workshop to learn about the Fulbright application process at Northwestern. We will discuss application components and successful application strategies. You do not need a draft of your essays, but will benefit most if you have a clear vision of your project.
May
24
Bacteriology journal club
Chicago - 2:00 PM - 3:00 PM
During bacteriology journal club, students and post-docs present their most recent research in progress or a bacteriology article of their choice
May
28
M-I Dept. Seminar / A Viral Noncoding Reshapes the Transcriptome of the Host Cell Through Novel Molecular Mechanisms
Chicago - 12:00 PM - 1:00 PM
Title: A Viral Noncoding Reshapes the Transcriptome of the Host Cell Through Novel Molecular Mechanisms
Speaker: Demián Cazalla, PhD, Department of Biochemistry, University of Utah School of Medicine
Topic:
Viruses express different kinds of noncoding RNAs (ncRNAs). Although identification of viral ncRNA species has been facilitated by the advent of high-throughput sequencing methods, ascribing functions to viral ncRNAs remains challenging. This shortcoming hinders our ability to understand how viruses create a cellular environment that permits the viral life cycle. I will describe our recent efforts to dissect the molecular functions of HSUR1, a viral ncRNA expressed by an oncogenic gammaherpesvirus that reshapes the transcriptome of the infected cell through novel molecular mechanisms.
Host: Jesus Ortega, Graduate Student, Lab of Eva Gottwein, PhD, Dept. of Microbiology-Immunology
May
28
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
May
28
Robert D. Goldman Lecture Presents: Dr. Jennifer Lippincott-Schwartz, PhD
Chicago - 3:30 PM - 4:30 PM
The Department of Cell and Developmental Biology and the Walter S. and Lucienne Driskill Graduate Program Lectures in Life Sciences invite you to the
Annual Robert D. Goldman Lecture
Please join us for a guest lecture and reception honoring Robert D. Goldman, PhD, and to celebrate his four decades of service as chair of the Department of Cell and Molecular Biology at Northwestern University Feinberg School of Medicine.
FEATURING:
Jennifer Lippincott-Schwartz, Ph.D.
Senior Group Leader,
Howard Hughes Medical Institute,
Janelia Research Campus, Ashburn, VA
"Emerging imaging technologies to study subcellular architecture, dynamics, and functions"
Abstract:
Powerful new ways to image the internal structures and complex dynamics of cells are revolutionizing cell biology and bio-medical research. In this talk, I will focus on how emerging fluorescent technologies are increasing spatio-temporal resolution dramatically, permitting simultaneous multispectral imaging of multiple cellular components. In addition, results will be discussed from whole cell milling using Focused Ion Beam Electron Microscopy (FIB-SEM), which reconstructs the entire cell volume at 4 voxel resolution. Using these tools, it is now possible to begin constructing a “organelle interactome”, describing the interrelationships of different subcellular organelles as they carry out critical functions. The same tools are also revealing new properties of organelles, including the roles of cytoskeletal elements like vimentin in controlling their organization and dynamism.
Tuesday, May 28, 2023
3:30–4:30 PM
Reception to follow
Hughes Auditorium, Lurie 1-133
303 E. Superior Street
For more information, please contact cdb@northwestern.edu.
Click here to subscribe to the CDB Seminar Series listserv.
May
29
CDB Trainee Seminar Series Presents: Adriana Landeros (Varma Lab) & Andrew Loiacono (Huang Lab)
Chicago - 12:00 PM - 1:00 PM
CDB Trainee Seminars Presents:
“Nuclear lamin A-associated proteins are required for centromere assembly"
Adriana Landeros
PhD Candidate, Varma Lab
12:00pm-12:30pm
“A protein critical for the perinucleolar compartment’s structure impacts tumor proliferation"
Andrew Loiacono
Research Technologist, Huang Lab
12:30pm-1:00pm
Refreshments to follow
1:00-2:00pm
Seminar: Wednesday, May 29, 2024
12:00-1:00pm
Simpson-Querrey Auditorium, SQ 1-230
Please contact cdb@northwestern.edu for more information or sign-up to our event listserv at https://www.feinberg.northwestern.edu/sites/cdb/about/listserv.html#listserv
May
31
Fulbright Research/Study/Arts Application Workshop
Evanston - 9:00 AM - 10:00 AM
Interested in pursuing research, study, or the arts abroad? Attend an application workshop to learn about the Fulbright application process at Northwestern. We will discuss application components and successful application strategies. You do not need a draft of your essays, but will benefit most if you have a clear vision of your project.
May
31
CDB Experts-in-the-field Seminar Series Presents: Jeremy Purvis, UNC School of Medicine
Chicago - 12:00 PM - 1:00 PM
CDB "EXPERTS-IN-THE-FIELD" SEMINAR PRESENTATION:
"Measuring, Modeling, and Targeting the Cell Cycle"
Jeremy Purvis, PhD
Professor
Department of Genetics
UNC School of Medicine
Chapel Hill, North Carolina
Friday, May 31, 2024
12:00–1:00 PM
Robert H Lurie Medical Research Center, Lurie 1-161
303 E. Superior St., Chicago
Host: Vipul Shukla
Assistant Professor
Department of Cell & Developmental Biology
Contact cdb@northwestern.edu for additional details or sign-up for our listserv at https://www.feinberg.northwestern.edu/sites/cdb/about/listserv.html#listserv
May
31
Neuroscience Seminar Series: Dr. Sama Ahmed
Chicago - 12:00 PM - 1:00 PM
Osama Ahmed, Ph.D., Assistant Professor and Weill Neurohub Term Assistant Professor
Bio
i am a weill neurohub term assistant professor in the department of psychology at the university of washington, seattle.
i completed my ph.d. training in neuroscience at ucsf and my postdoctoral tenure in the Murthy lab at the princeton neuroscience institute. my research interests span systems neuroscience, cognitive psychology, evolutionary biology, and genetics. currently, i am excited to delve deeper into the neurobiology of multitasking as a way to study how nervous systems generate and constrain different behaviors.
as a researcher, i am keen to practice science within alternate value systems that promote equity, safety, creativity, and imagination.
i acknowledge that the ahmed lab will operate on stolen Coast Salish land, on the ancestral lands of the Suquamish, Tulalip, and Muckleshoot Tribes. this acknowledgement is one way of resisting the erasure of indigenous histories and knowledge, and foregrounds our efforts to work differently in relationship to ourselves, each other, and the spaces wherein we work and live.
i am thankful to the BRAINS fellowship, the Burroughs Wellcome Fund, Weill NeuroHub, the Simons Collaboration on the Global Brain, and the UW for supporting our research.
May
31
Bacteriology journal club
Chicago - 2:00 PM - 3:00 PM
During bacteriology journal club, students and post-docs present their most recent research in progress or a bacteriology article of their choice
Jun
02
31st Annual Cancer Survivors' Celebration Walk & 5K
Off-Campus - 8:30 AM - 9:15 AM
For 31 years, Lurie Cancer Center’s Cancer Survivors’ Celebration Walk & 5K has been a source of hope and inspiration for people who have faced or are facing cancer. Held in Chicago’s Grant Park, our community event is a unique opportunity for cancer survivors, supporters, scientists and health professionals to connect, celebrate milestones, and make an impact on the future of cancer care.
We’re excited to run, walk and celebrate together on National Cancer Survivors Day! We strongly encourage you to register in advance. You must register by May 3 to receive your T-shirt before the event. If you register after May 3, you may pick up your T-shirt on the day of the event.
Highlights include:
- A non-competitive walk or chip-timed 5K race along the lakefront
- A commemorative T-shirt
- Music, entertainment, inspiring speakers and Dedication Wall
- Refreshments and activities for the family
Net proceeds and funds raised from our 31st annual event will help to advance groundbreaking cancer research and treatment at Robert H. Lurie Comprehensive Cancer Center of Northwestern University at Northwestern Memorial Hospital. We hope you will join the donors, sponsors and fundraising teams who support our efforts by creating a personalized fundraising page when you register. Fundraising is optional, and no minimum is required.
Jun
04
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
Jun
05
CDB Faculty Meeting
No Location - 12:00 PM - 1:00 PM
Cell & Developmental Biology Faculty Meeting.
Departmental faculty meet every first Wednesday from 12-1 PM. Calendar invites with the meeting location are disseminated in advance. Please contact cdb@northwestern.edu for more information.
Jun
07
Bacteriology journal club
Chicago - 2:00 PM - 3:00 PM
During bacteriology journal club, students and post-docs present their most recent research in progress or a bacteriology article of their choice
Jun
11
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
Jun
12
CDB Experts-in-the-field Seminar Series Presents: Kristy Red Horse, Stanford University
Chicago - 12:00 PM - 1:00 PM
CDB "EXPERTS-IN-THE-FIELD" SEMINAR PRESENTATION:
"Title TBD"
Kristy Red Horse, PhD
Associate Professor
Biology
Stanford University
Stanford, California
Wednesday, June 12, 2024
12:00–1:00 PM
Simpson-Querrey Auditorium, SQ 1-230
303 E. Superior St., Chicago
Host: Millie Romay & Eve Suva (Trainee Representatives)
Trainee Representatives
Department of Cell & Developmental Biology
Contact cdb@northwestern.edu for additional details or sign-up for our listserv at https://www.feinberg.northwestern.edu/sites/cdb/about/listserv.html#listserv
Jun
12
Lurie Cancer Center Symposium & Scientific Poster Session
Chicago - 2:00 PM - 6:30 PM
Please join us on Wednesday, June 12 for the Lurie Cancer Center Symposium to learn about groundbreaking research taking place in laboratories of Lurie Cancer Center members on Northwestern University's Evanston and Chicago campuses.
Jun
14
Bacteriology journal club
Chicago - 2:00 PM - 3:00 PM
During bacteriology journal club, students and post-docs present their most recent research in progress or a bacteriology article of their choice
Jun
18
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
Jun
19
CDB Faculty Seminar Presents: Richard Morimoto, PhD (Evanston Campus)
Chicago - 12:00 PM - 1:00 PM
CDB Faculty Seminars Presents:
"Title TBD"
Richard Morimoto, PhD
Professor
Department of Molecular Biosciences
Evanston, Northwestern
Wednesday, June 21, 2024
12:00–1:00 PM
Simpson Querrey Auditorium, SQ 1-230
Contact cdb@northwestern.edu for additional details or sign-up for our listserv at https://www.feinberg.northwestern.edu/sites/cdb/about/listserv.html#listserv
Jun
20
18th Annual Pain & Palliative Care Conference
Chicago - 8:00 AM - 3:30 PM
On Thursday, June 20, 2024, the 18th Annual Pain & Palliative Care Conference will bring together physicians, nurses, social workers, chaplains and healthcare professionals to share research and clinical best practices to advance the field of palliative care and improve care for patients with serious illnesses and their loved ones.
Jun
21
Neuroscience Seminar Series: Dr. Tina K Kim
Chicago - 12:00 PM - 1:00 PM
CHRISTINA K. KIM, PH.D., PRINCIPAL INVESTIGATOR, University of California, Davis
Assistant Professor | Center for Neuroscience, Department of Neurology
Affiliate Faculty | Genome Center, Center for Neuroengineering & Medicine
Background. Tina received her AB in Molecular Biology from Princeton University in 2011, and her Ph.D. in Neuroscience from Stanford University in 2017 with Karl Deisseroth. She completed her postdoctoral training with Alice Ting at Stanford in 2021.
Research interests. Functional and molecular profiling, protein engineering, technology development, systems neuroscience, motivated behaviors and decision making, in vivo imaging and manipulation of neural activity.
Jun
25
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
Jun
26
CDB Trainee Seminar Series Presents: Alicia Lin (Huang Lab) & Anwar Siddique (Hope Lab)
Chicago - 12:00 PM - 1:00 PM
CDB Trainee Seminars Presents:
“Title TBD"
Alicia Lin
Title, Huang Lab
Cell and Developmental Biology
“Title TBD"
Anwar Siddique
Graduate Student, Hope Lab
Cell and Developmental Biology
Refreshments to follow
1:00-2:00pm
Wednesday, June 26, 2024
12:00-1:00pm
Simpson-Querrey Auditorium, SQ 1-230
Please contact cdb@northwestern.edu for more information or sign-up to our event listserv at https://www.feinberg.northwestern.edu/sites/cdb/about/listserv.html#listserv
Jun
28
Bacteriology journal club
Chicago - 2:00 PM - 3:00 PM
During bacteriology journal club, students and post-docs present their most recent research in progress or a bacteriology article of their choice
Jul
02
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
Jul
09
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
Jul
12
Jul
16
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.
Jul
23
Immunology Discussion Club
Chicago - 1:00 PM - 2:00 PM
The Northwestern Immunology Discussion Club meets on Tuesdays from 1:00pm to 2:00pm and is led by Dr. Booki Min from Feinberg Department- Microbiology and Immunology and Dr. Stephanie Eisenbarth- Williams from The Center for Human Immunology. We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Last Tuesday on the month are Research In Progress talks. Feel free to be creative! Note- members are required to present at least 1 IDC and 1RIP per year.