News and Announcements

Investigators led by Navdeep Chandel, PhD, have discovered how mitochondrial metabolism supports T-cell proliferation and also prevents T-cell exhaustion in cancer and chronic infection, according to a recent study published in Nature Immunology.

Screening for common genetic variants in addition to rare genetic variants can help improve patient risk stratification for heart failure, according to a recent Northwestern Medicine study published in Nature Genetics.

Ali Shilatifard, PhD, the Robert Francis Furchgott Professor and chair of Biochemistry and Molecular Genetics, has been elected to the National Academy of Sciences.

Northwestern Medicine investigators have discovered how disruptions in circadian rhythm in our muscles combined with poor diet can contribute to the development of diabetes, according to a recent study published in Proceedings of the National Academy of Sciences.

Northwestern Medicine scientists have discovered that inhibiting the GATA6 protein in mouse models of colon cancer reduced tumor growth and improved survival, underscoring the potential of a new therapeutic target for colon cancer, according to a recent study published in Science Advances.

Northwestern Medicine scientists have discovered new details about how the human genome produces instructions for creating the building blocks of life, according to a new study published in Science Advances.

Northwestern Medicine investigators have discovered a novel mechanism that recognizes and eliminates ‘bad’ transcriptional elongation enzymes during gene expression, findings that may inform the understanding of adrenal diseases, according to a recent study published in Science Advances.

Northwestern scientists have discovered how mitochondria influence the body’s immune response through modulating specific cell signaling pathways, according to a recent study published in Science Advances.

A new study has provided direct evidence in mice that the drug reversibly cuts the cell’s energy supply by interfering with mitochondria to lower glucose levels.

Distinguished biochemist Ron Evans, PhD, director of the Gene Expression Laboratory and professor at the Salk Institute for Biological Studies, has been named the winner of the annual $250,000 Kimberly Prize in Biochemistry and Molecular Genetics.

Scientists have discovered how interactions between RNA and the TOP1 essential enzyme, which is overexpressed in many human cancers, regulate DNA during transcription and may inform the creation of new cancer therapies, according to a Northwestern Medicine study published in Molecular Cell.

Northwestern Medicine scientists have discovered new insights into the production and regulation of an emerging class of noncoding RNAs in three major types of cancer, according to findings published in Science Advances.

Northwestern Medicine scientists have discovered that mitochondria are not necessary for the proliferation of immune cells called microglia, but do help them respond to demyelinating injury, according to a study published in Nature Metabolism.

A multiprotein complex is essential for regulating cellular transcription response to oxygen deprivation, a key feature of cancer, according to a Northwestern Medicine study published in the Proceedings of the National Academy of Sciences.

Influential biochemist Craig M. Crews, PhD, who pioneered the pharmaceutical field of targeted protein degradation, delivered the second Kimberly Prize in Biochemistry and Molecular Genetics Lecture to a full auditorium of Feinberg faculty, staff, fellows and students.