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Earl Y. Cheng, MD
Associate Professor

Dr. Cheng has been an Associate Professor in the Department of Urology at Northwestern University’s Feinberg School of Medicine since 2002.  His clinical expertise is in the area of complex urinary tract reconstruction and hypospadias. Dr. Cheng's basic science research focuses on the areas of tissue engineering and bladder physiology. He is currently collaborating with Dr. Samuel Stupp, a leader in the field of nanotechnology, and Dr. Bradley Kropp at the University of Oklahoma. Together, they are investigating different methods of promoting tissue specific regeneration in the urinary tract with an emphasis on bladder regeneration. Dr. Cheng currently has a grant from the New York Academy of Medicine and the National Institutes of Health to determine the differences that exist between cultured cells from the neuropathic bladder and normal bladder and the implications that these differences have for future tissue engineering techniques.  His clinical expertise is in the area of complex urinary tract reconstruction and hypospadias.

Education

Undergraduate: Northwestern University, Evanston, IL
Medical School: Feinberg School of Medicine, Northwestern University, Chicago, IL
Internship: General Surgery, McGaw Medical Center of Northwestern University, Chicago, IL
Surgery residency: McGaw Medical Center of Northwestern University, Chicago, IL
Urology residency: McGaw Medical Center of Northwestern University, Chicago, IL
Fellowship: Pediatric Urology, Children's Memorial Hospital, Chicago, IL

Selected Publications
The following publications are selected from a complete CV.  For more information on Dr. Cheng's scholarly productivity, please contact his office.

Journal Articles

1. Cheng EY, Oyasu R, Grayhack JT, McVary KT. Reversed seromuscular grafts in the urinary tract in dogs. J Urol. 152(2):2252. 1994.
2. Cheng EY, Grammatopoulos T, Lee C, Sensibar J, Decker R, Kaplan WE, Maizels M, Firlit CF. Angiotensin II and basic fibroblast growth factor induce neonatal bladder stromal cell mitogenesis. J Urol. 156(2 Pt 2):593-7. 1996.
3. Cheng EY, Richards I, Balcom A, Steinhardt G, Diamond M, Rich M, Donovan JM, Carr MC, Reinberg Y, Hurt G, Chandra M, Bauer SB, Kaplan WE. Bladder stimulation therapy improves bladder compliance: results from multi-institutional trial. J Urol. 156(2 Pt 2):761-4. 1996.
4. Cheng EY, Richards I, Kaplan WE. Use of bladder stimulation in high risk patients. J Urol. 156(2 Pt 2):749-52. 1996.
5. Cheng EY, Lee C, Decker R, Sensibar JA, Lang S, Kaplan WE, Maizels M, Firlit CF. Captopril (an inhibitor of angiotensin converting enzyme) inhibits obstructive changes in the neonatal rabbit bladder. Urology. 50(3):465-71. 1997.
6. Palmer LS, Maizels M, Kaplan WE, Firlit CF, Cheng EY. Urine levels of transforming growth factor–beta 1 in children with ureteropelvic junction obstruction. Urology. 50(5):769-73. 1997.
7. Palmer LS, Lee C, Decker RS, Lang S, Kaplan WE, Firlit CF, Cheng EY. The effect of angiotensin converting enzyme inhibition and angiotensin II receptor antagonism on obstructed rat bladder. J Urol. 158(3 Pt 2):1100-4. 1997.
8. Cheng EY, Decker RS, Lee C. Role of angiotensin II in bladder smooth muscle growth and function. Adv Exp Med Biol. 462:183-91. 1999.
9. Furness PD III, Maizels M, Han SW, Cohn RA, Cheng EY. Elevated bladder urine concentration of transforming growth factor-beta1 correlates with upper urinary tract obstruction in children. J Urol. 162(3 Pt 2):1033-6. 1999.
10. Kropp BP, Zhang YY, Tomasek JJ, Cowan R, Furness PD III, Vaughan MB, Parizi M, Cheng EY. Characterization of cultured bladder smooth muscle cells: assessment of in vitro contractility. J Urol. 162(5):1779-84. 1999.
11. Cheng EY. Cellular factors and the obstructed bladder. J Urol. 164(4):1334-5. 2000.
12. Zhang Y, Kropp BP, Moore P, Cowan R, Furness PD III, Kolligian ME, Frey P, Cheng EY. Coculture of bladder urothelial and smooth muscle cells on small intestinal submucosa: potential applications for tissue engineering technology. J Urol. 164(3 Pt 2):928-34, discussion 934-5. 2000.
13. Cheng EY, Kropp BP. Urologic tissue engineering with small-intestinal submucosa: potential clinical applications. World J Urol. 18(1):26-30. 2000.
14. Bankhead RW, Kropp BP, Cheng EY. Evaluation and treatment of children with neurogenic bladders. J Child Neurol. 15(3):141-9. 2000.
15. Kropp BP, Cheng EY. Bioengineering organs using small intestinal submucosa scaffolds: in vivo tissue-engineering technology. J Endourol. 14(1):59-62. 2000.
16. Han SW, Maizels M, Chou PM, Fernbach SK, Cheng EY, Furness PD III. Lamina muscularis propria thickness of renal pelvis predicts radiological outcome of surgical correction of ureteropelvic junction obstruction. J Urol. 165(5):1648-51. 2001.
17. Colvert JR III, Kropp BP, Cheng EY, Pope JC IV, Brock JW III, Adams MC, Austin P, Furness PD III, Koyle MA. The use of small intestinal submucosa as an off-the-shelf urethral sling material for pediatric urinary incontinence. J Urol. 168(4 Pt 2):1872-5; discussion 1875-6. 2002.
18. Cheng EY, Vemulapalli SN, Kropp BP, Pope JC IV, Furness PD III, Kaplan WE, Smith DP. Snodgrass hypospadias repair with vascularized flap: the perfect repair for virgin cases of hypospadias? J Urol. 168(4 Pt 2):1723-6; discussion 1726. 2002.
19. Cheng EY, Kropp BP, Pope JC IV, Brock JW III. Proximal division of the urethral plate in staged hypospadias repair. J Urol. 170(4 Pt 2):1580-3; discussion 1584. 2003.
20. Lin HK, Cowan R, Moore P, Zhang Y, Yang Q, Peterson JA Jr, Tomasek JJ, Kropp BP, Cheng EY. Characterization of neuropathic bladder smooth muscle cells in culture. J Urol. 171(3):1348-52. 2003.
21. Husmann DA, Snodgrass WT, Koyle MA, Furness PD III, Kropp BP, Cheng EY, Kaplan WE,  Kramer SA. Ureterocystoplasty: indications for successful augmentation. J Urol. 171(1):376-80. 2003.
22. Zhang Y, Kropp BP, Lin HK, Cowan R, Cheng EY. Bladder regeneration with cell-seeded small intestinal submucosa. Tissue Eng. 10(1-2):181-7. 2004.
23. Beqaj SH, Donovan JL, Liu DB, Harrington DA, Alpert SA, Cheng EY. Role of basic fibroblast growth factor in the neuropathic bladder phenotype. J Urol. 174(4 Pt 2):1699-1703. 2005.
24. Alpert SA, Cheng EY, Kaplan WE, Snodgrass WT, Wilcox DT, Kropp BP. Bladder neck fistula after the complete primary repair of exstrophy: a multi-institutional experience. J Urol. 174(4 Pt 2):1687-89. 2005.
25. Alpert SA, Cheng EY, Zebold KE, Kaplan WE. Clean intermittent catheterization in genitally sensate children: patient experience and health related quality of life. J Urol. 174(4 Pt 2):1616-9; discussion 1619. 2005.

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