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Qiang Zhang, MD, PhD
Research Assistant Professor
Dr. Zhang was appointed as Research Assistant Professor of Urology in 2004. He graduated with an MD from Fujian Medical University (PRC) in 1993 and went on to complete his general surgery and urology residency training there. Dr. Zhang earned his PhD from Peking University in Beijing in 2001. He continued his training with a 2-year postdoctoral fellowship at Northwestern University, which was funded through an American Foundation for Urologic Disease (AFUD) scholarship. Dr. Zhang’s research interests include prostate cancer immunotherapy by adoptive transfer of tumor reactive TGF-beta-insensitive CD8+ T cells and methylation of the promoters of TGF-beta receptors.
Education
Medical School: Fujian Medical University, Fuzhou, Fujian, PRC
Surgery Residency: Fujian Medical University, Fuzhou, Fujian, PRC
Urology Residency: Fujian Medical University, Fuzhou, Fujian, PRC
Graduate: Urology, Molecular and Cell Biology, Institute of Urology, Peking University, Bejing, PRC
Post-graduate: Molecular Biology & Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL
Selected Publications
The following publications are selected from a total of 50 journal articles. For more information on Dr. Zhang's scholarly productivity, please contact his office.
Journal Articles
1. Qiang Zhang, Zhifu Chen, Zuolin Shi. Mechanism of Mutidrug Resistance of Renal Cell Carcinoma and its Reversion. Chinese Journal of Urology, 1999, 20(1): 51-54.
2. Qiang Zhang, Zhiwen Zhang, Yinglu Guo, et al. Suprression subtractive hybridization and oncogenes clone. Foreign Medical Sciences Cancer Section. 2000, 27(6): 362-364.
3. Qiang Zhang, Zhifu Chen, Zuolin Shi, et al. Mechanism of Drug Resistance of Primary Renal Cell Carcinoma and Their Significance. Chinese Journal of Oncology, 2000, 22(2): 145-148.
4. Qiang Zhang, Zhiwen Zhang, Yinglu Guo, et al. The Progression in Research about Renal Cell Carcinoma Relative Genes. Chinese Journal of Urology, 2001, 22(5): 313-315.
5. Qiang Zhang, Zhiwen Zhang, Yinglu Guo, et al. Suppression subtractive hybridization for identifying differentially expressed genes in renal cell carcinoma. Chinese Medical Journal, 2001, 114(8): 807-812.
6. Lin Chen, Qiang Zhang, Zhiwen Zhang, et al. Research progress of P16 in hematology. Chinese Journal of Internal Medicine, 2001, 40(4): 279-281.
7. Qiang Zhang, Zhiwen Zhang, Yinglu Guo, et al. Cloning and Identification of Renal Cell Carcinoma Relative Novel Gene — GYLZ-RCC18. Chinese Medical Journal (English edition), 2002, 115 (5): 746-749.
8. Qiang Zhang, Ximing Yang, Michael Pins, Borko Javonovic, Timothy Kuzel, Seong-Jin Kim, Luk Van Parijs, Norman M. Greenberg, Victoria Liu, Yinglu Guo, and Chung Lee. Adoptive transfer of tumor-reactive transforming growth factor-beta-b insensitive CD8+ T cells: eradication of autologous mouse prostate cancer. Cancer Research. 2005, 1;65 (5):1761-1769.
9. Qiang Zhang*, Jonathan N. Rubenstein, Thomas L Jang, Michael Pins, Borko Javonovic, Ximing Yang, Seong-Jin Kim, Irwin Park, Victoria Liu, and Chung Lee*. Insensitivity to transforming growth factor-β results from promoter methylation of cognate receptors in human prostate cancer cells (LNCaP). Molecular Endocrinology. 2005, 19 (9): 2390-2399. (* corresponding author).
10. Qiang Zhang, Jonathan N Rubenstein, Victoria Liu, Irwin Park, Chung Lee. Restoration of expression of transforming growth factor-β type II receptor in murine renal cell carcinoma (renca) cells by 5-Aza-2'-deoxycytidine. Life Science. 2005, 76 (10):1159-1166.
11. Qiang Zhang, Shilajit Kundu, Ximing Yang, Michael Pins, Borko Javonovic, Timothy Kuzel, Seong-Jin Kim, Luk Van Parijs, Norman M. Greenberg, Yinglu Guo, and Chung Lee. Blockade of TGF-b signaling in tumor-reactive CD8+ T cells activates the anti-tumor immune response cycle. Molecular Cancer Therapeutics. 2006, 5(8):1733-1743.
12. Qiang Zhang, Ximing Yang, Michael Pins, Borko Javonovic, Timothy Kuzel, Seong-Jin Kim, Luk Van Parijs, Norman M. Greenberg, Victoria Liu, Yinglu Guo, and Chung Lee. Infiltration of tumor-reactive transforming growth factor-β insensitive CD8+ T cells into the tumor parenchyma is associated with apoptosis and rejection of tumor cells. Prostate 2006; 66(3):235-47.
13. Qiang Zhang, Wei Zhou, Thomas L. Jang, Lili Liang, Yinglu Guo, Dianqi Xin and Chung Lee. Leader sequence triggers and enhances multiple functions of clusterin and is instrumental in the progression of human prostate cancer in vivo and in vitro. BJU International. 2006, 98(2): 452-60.
14. Victoria C. Liu, Larry Y. Wong, Thomas Jang, Ali H. Shah, Irwin Park, Ximing J.Yang, Qiang Zhang, Scott Lonning, Beverly A. Teicher, and Chung Lee. Tumor Evasion of the Immune System by Converting CD4+CD25- T Cells into CD4+CD25+ T Regulatory Cells: Role of Tumor-Derived TGF-β. Journal of Immunology. 2007, 178 (5): 2883-2892.
15. FuLi Wang, WeiJun Qin, WeiHong Wen, Feng Tian, Bin Song, Qiang Zhang, Chung Lee, Weide Zhong, YingLu Guo and He Wang. TGF-β insensitive dendritic cells: an efficient vaccine for murine prostate cancer. Cancer Immunology, Immunotherapy. 2007 56 (11):1785-93.
16. Feng Tian, Wang L, Weijun Qin, Fuli Wang, Bin Song, Li Y, Weihong Wen, Zhang Z, Zhu K, Qiang Zhang, Chung Lee, Weide Zhong, Yinglu Guo, He Wang. Vaccination with transforming growth factor-beta insensitive dendritic cells suppresses pulmonary metastases of renal carcinoma in mice. Cancer Letter. 2008; 271 (2): 333-41.
17. Kent Perry, Larry Wong, Victoria Liu, Irwin Park, Qiang Zhang, Varun Rejen, Xuemei Huang, Norm D. Smith, Borko Jovanovic, Scott Lonning, Beverly A. Teicher and Chung Lee. Treatment of transforming growth factor-beta (TGF-β) insensitive mouse Renca tumor by TGF-β elimination. Urology. 2008;72(1):225-9.
18. Qin Weijun, Feng Tian, Fuli Wang, Bin Song, He Wang, Qiang Zhang, Borko Jovanovic, Lili Liang, Yinglu Guo, Norm Smith and Chung Lee. Adoptive transfer of tumor reactive TGF-β insensitive cytolytic T cells for the treatment of established mouse Renca tumors. Urology. 2008; 72 (4): 943-7.
19. Shilajit D. Kundu, Chung Lee, Benjamin K. Billips, Geoffrey M. Habermacher, Victoria Liu, Qiang Zhang, Larry Y. Wong, David J. Klumpp, Praveen Thumbikat* The Toll Like Receptor Pathway: A Novel Mechanism of Infection-Induced Carcinogenesis of Prostate Epithelial Cells. Prostate. 2008, 68(2):223-229.
20. Xunrong Luo, Qiang Zhang, Victoria Liu, Zenbiao Xia and Chung Lee. TGF-β Induced Expression of Foxp3 in T cells is Mediated Through Inactivation of ERK. Journal of Immunology. 2008 180(5):2757-2761.
21. Irwin I. Park, Qiang Zhang, Victoria Liu, James M Kozlowski, Ju Zhang, Chung Lee. 17β-estradiol at low concentrations acts through distinct pathways in normal versus BPH-derived prostate stromal cells. Endocrinology 2009;150 (10):4594-605.
22. Qiang Zhang*, Brian T. Helfand, Thomas Jang, Lihua J, Zhu, Lin Chen, Michael Pins, Borko Javonovic, Ximing J. Yang, and Chung Lee*. NF-kB mediated TGF-β-induced epithelial mesenchymal transition predicts the prognosis of prostate cancer. Clinical Cancer Research. 2009; 15(10): 3557-3567. (*corresponding author).
23. Longxin Wang, Fuli Wang, Jianlin Yuan, Weihong Wen, Yu Li, Qinchuang Dong, Geng Zhang, Weide Zhong, Zheng Zhang, Chung Lee, Yinglu Guo, He Wang, Qiang Zhang* and Weijun Qin*. Superior anti-tumor responses induced by autologous transforming growth factor Beta insensitive CD8+ T cells in humanized SCID mice. Clinical Cancer Research 2009; (In press) (*corresponding author).
Books
- Zhongcheng Xin, Yinglu Guo, Qiang Zhang. Surgery Therapy for Dysfunction of Male Erection. Beijing, PRC; Beijing Medical University Publishing Company; 2001.
Northwestern University, Feinberg School of Medicine
Department of Urology
303 East Chicago Avenue, Tarry 16-703
Chicago, IL 60611-3008
(312) 908-7963
Fax (312) 908-7275
q-zhang2@northwestern.edu