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Tetiana Zaichuk, PhD
Research Assistant Professor
Dr. Tetiana Zaichuk joined the Department of Urology at the Northwestern Feinberg School of Medicine as Assistant Research Professor in 2008. Dr. Zaichuk obtained her PhD from Engelgardt Institute of Molecular Biology, National Academy of Sciences in Moscow. She received her post-doctoral training at the Institut Andre Lwoff and at the Centre d’Etude Nucleares, both funded through the Association for Cancer Research and the Foundation for Medical Research (France). Further training was received in the Department of Urology at Northwestern University’s Feinberg School of Medicine.
Prior to obtaining her current position in the Department of Urology, Dr. Zaichuk held an Instructor position in the Department of Molecular Biology at The University of Illinois, Chicago, and acted as Research Assistant Professor in the Department of Surgery at Northwestern.
Dr. Zaichuk’s areas of expertise include tumor suppressor genes, angiogenesis, and tissue-specific regulation of gene expression. Her current research project focuses on understanding the host response to interactions with uropathogenic E. coli.
Master’s degree: Biochemistry, Ukrainian State University, College of Biology, Kiev, Ukraine
Doctorate: PhD, Molecular Biology, Engelgardt Institute of Molecular Biology, National Academy of Sciences, Moscow, Russia.
Post-graduate: Institut Andre Lwoff, Villejuif, France; Centre d’Etude Nucleares, Fontenay-aux-Roses, France; Feinberg School of Medicine, Northwestern University, Chicago, IL
Selected Publications
The following publications are selected from a complete CV. For more information on Dr. Zaichuk's scholarly productivity, please contact her office.
Journal Articles
1. Zaichuk T., Ivancic D., Scholtens D., Schiller C., Khan SA. Tissue-specific transcripts of human steroid sulfatase are under control of estrogen signaling pathways in breast carcinoma. J Steroid Biochem Mol Biol. 2007, 105(1-2):76–84.
2. Filleur S, Volz K, Nelius T, Mirochnik Y, Huang H, Zaichuk TA, Aymerich MS, Becerra SP, Yap R, Veliceasa D, Shroff EH, Volpert OV. Two functional epitopes of pigment epithelial-derived factor block angiogenesis and induce differentiation in prostate cancer. Cancer Res. 2005; 65(12):5144-52.
3. Quesada 10. A.J., Nelius, T., Yap, R., Zaichuk T.A., Alfranca, A., Filleur, S., Volpert OV., Redondo JM. In vivo up-regulation of CD95 and CD95L causes synergistic inhibition of angiogenesis by TSP1 peptide and metronomic doxorubicin treatment. Cell Death Differ. 2005; 12(6):649-58.
4. Zaichuk T., Shroff E., Emanuel R., Filleur S., Nelius T. and Volpert OV. Nuclear factor of activated T cells balances angiogenesis activation and inhibition. J Exp Med. 2004; 199(11):1513-22.
5. Volpert O.V. Pili R., Sikder H.A., Nelius T., Zaichuk T., Morris C., Shiflett C.B., Devlin M.K., Conant K., Alani R.M. Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1. Cancer Cell (2002), 2, 1-11
6. Volpert O.V. Zaichuk T., Zhou W., Reiher F., Ferguson T.A., Stuart P.M., Amin M., Bouck N.P. Inducer-stimulated fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor. Nature Medicine (2002), 8(4), 349-357.
7. Bouvard V., Zaitchouk T., Vacher M., Duthu A., Canivet M., Choisy-Rossi C., Nierushalski M.and May E.. Tissue and cell-specific expression of the p53-target genes: bax, fas, mdm2 and waf1/p21, before and following ionising radiation in mice. Oncogene (2000), 19(5),649-660.
8. Yonish-Rouach E., Deguin V., Zaitchouk T., Breugnot C., Mishal Z., Jenkins J.R. and May E. Transcriptional acivation plays a role in the induction of apoptosis by transiently transfected wild-type p53. Oncogene (1995) 11, 2197-2205.
9. Zaichuk TA, Kuznetsov NV, Osovskaia VS, Kopnin BP, Chumakov PM. Specific DNA-binding properties of oncoprotein p53 in human tumor cells. Proc. Acad. Sci. (Russia) 1993;330(3):379-82.
10. Tarakhovski AM, Zaichuk TA, Prassolov VS, Butenko ZA. A 25 kD polypeptide is the ligand for p185 neu and is secreted by activated macrophages. Oncogene (1991) 6, 2187-2196.
11. Tarakhovski AM, Reznikov MV, Zaichuk TA, Tugusheva M, Butenko ZA, Prassolov VS. Polymorphic changes of cell phenotype caused by elevated expression of an endogenous NEU protooncogene. Oncogene (1990) 5, 405-410.
Northwestern University, Feinberg School of Medicine
Department of Urology
303 East Chicago Avenue, Tarry 16-703
Chicago, IL 60611-3008
(312) 908-8145
Fax (312) 908-7275
t-zaichuk@northwestern.edu