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Dale K. Shumaker, PhD
Research Assistant Professor
Dr. Dale Shumaker completed his BS in Cell and Molecular Biology from the University of Michigan. He received his PhD at Johns Hopkins University in the Department of Cell Biology and Anatomy while examining the role of lamin binding proteins on nuclear assembly and their interaction with DNA and a DNA binding protein in Dr. Katherine L. Wilson’s laboratory. Dr. Shumaker moved to Northwestern University in 2001 to perform additional research on Lamin Structure and Function in Dr. Robert Goldman’s laboratory.
In Fall of 2008, Dr. Shumaker joined the Department of Urology at Northwestern University’s Feinberg School of Medicine as a Research Assistant Professor. His continuing laboratory work with Dr. Brian Helfand focuses on the cell biology of prostate cancer, specifically examining changes in nuclear lamins and the effect on nuclear architecture. Additional laboratory work examines the role of the cytoplasmic intermediate filaments in prostate cancer.
Dr. Shumaker has won several awards in the cell biology field and is a member of the American Society of Cell Biology.
Undergraduate: Cell and Molecular Biology, University of Michigan, Ann Arbor, MI
Post-graduate: Cellular and Mollecular Biology, Johns Hopkins University, Baltimore, MD
Selected Publications
The following publications are selected from a complete CV. For more information on Dr. Shumaker's scholarly productivity, please contact his office.
Journal Articles
1. Varani J, Taylor CG, Riser B, Shumaker DK, Yeh K-Y, Dame M, Gibbs DF, Todd RF III, Dumler F, Bromberg J, and Killen PD. 1992. Mesangial cell killing by leukocytes: role of leukocyte oxidants and proteolytic enzymes. Kidney Int. 42:1169-1177.
2. Shumaker DK, Sklar MD, Prochownik EV, and Varani J. 1994. Increased cell-substrate adhesion accompanies conditional reversion to the normal phenotype in ras-oncogenetransformed
NIH-3T3 cells. Exp. Cell Res. 214:440-446.
3. Merchant JL, Shiotani A, Morensen ER, Shumaker DK, and Abraczinskas DR. 1995. Epidermal growth factor stimulation of the human gastrin promoter requires Sp1. J. Biol Chem. 270:6314-6319.
4. Shumaker DK, Vann LR, Goldberg MW, Allen TD, and Wilson KL. 1998. TPEN aZn /Fe chelator with low affinity for Ca , inhibits l 2+ 2+ 2+ amin assembly, destabilizes nuclear architecture and my independently protect nuclei from apoptosis in vitro. Cell Calcium. 23:151-164.
5. Shumaker DK, Lee KK, Tanhehco YC, Craigie R, and Wilson KL. 2001. LAP2 binds to BAF•DNA complexes: requirement for the LEM-domain and modulation by variable regions. EMBO J. 20:1754-1764.
6. Goldman RD, Gruenbaum Y, Moir RD, Shumaker DK, and Spann TP. 2002. Nuclear lamins: building blocks of nuclear architecture. Genes Dev. 16:533-547.
7. Shumaker DK, Kuczmarski ER, Goldman RD. 2003. The nucleoskeleton: lamins and actin are major players in essential nuclear functions. Curr. Opin. Cell Biol.15:358-66.
8. Goldman RD, Shumaker DK, Erdos MR, Eriksson M, Goldman AE, Gordon LB, Gruenbaum Y, Khuon S, Mendez M, Varga R, and Collins FS. 2004. Accumulation of Mutant Lamin A Causes Progressive Changes in Nuclear Architecture in Hutchinson-Gilford Progeria Syndrome. Proc. Natl. Acad. Sci. USA. 101:8963-8.
9. Gruenbaum Y, Margalit A, Goldman RD, Shumaker DK, Wilson KL. 2005. The Nuclear Lamina Comes of Age. Nat. Rev. Mol. Cell Biol. 6:21-31.
10. Goldman RD, Goldman AE, and Shumaker DK. 2005. Nuclear Lamins: Building Blocks of Nuclear Structure and Function. Novartis Found Symp. 264:3-15; discussion 16-21.
11. Shumaker DK, Lopez-Soler RI, Adam SA, Herrmann H, Moir RD, Spann TP, and Goldman RD. 2005. Functions and Dysfunctions of the Nuclear Lamin Ig-fold Domain:Nuclear Assembly, Growth and Emery-Dreifuss Muscular Dystrophy. Proc. Nat. Acad. Sci. USA. 102:15494.
12. Helfand BT, Chou YH, Shumaker DK, Goldman RD. 2005. Intermediate Filament Proteins Participate in Signal Transduction. Trends Cell Biol. 15:568-70. 2005.
13. Tsai MY, Wang S, Heidinger JM, Shumaker DK, Adam SA, Goldman RD, and Zheng Y. 2006. A Mitotic Lamin B Matrix Induced by RanGTP Required for Spindle Assembly. Science. 311:1887-93.
14. Shumaker DK, Dechat T, Kohlmaier A, Bozovsky MR, Godlman AE, Khoun S, Adam SA, Erdos MR, Eriksson M, Collins FS, Jenuwein T, and Goldman RD. 2006. Mutant Nuclear Lamin A Leads to Progressive Alterations of Epigenetic Control in Premature Aging. Proc. Nat. Acad. Sci. USA. 103:8703-8.
15. Dechat T, Pfleghaar K, Sengupta K, Shimi T, Shumaker DK, Solimando L, and Goldman RD. 2008. Nuclear Lamins: Major Factors in the Functional Organization and Epigenetic Regulation of Chromatin. Invited Review for Genes and Development. 22:832-53.
16. Shumaker DK, Solimando L, Sengupta K, Adam SA, Grunwald A, Strelkov S, Aebi U, Cardoso MC, and Goldman RD. 2008. Highly Conserved Nuclear Lamin Ig-fold Binds to PCNA: Its Role in DNA Replication. JCB. 181:269-80.
Northwestern University, Feinberg School of Medicine
Department of Urology
300 East Chicago Avenue, Ward 11-145
Chicago, IL 60611
(312) 503-1556
dshumake@northwestern.edu