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James M. Kozlowski, MD, FACS
Professor

Dr. Kozlowski has been an important member of the Department of Urology faculty since his arrival. He coordinates the urology curriculum for medical students and continues to win awards for his excellence in teaching through election by the medical students. In addition, he is involved in prostate cancer and apoptosis research. He is also active in multidisciplinary collaboration with faculty in the Departments of Radiology, Pathology and Hematology/Oncology.

Education

Undergraduate: Loyola University of Chicago, Chicago, IL
Medical school: Feinberg School of Medicine, Northwestern University, Chicago, IL
Internship: General Surgery, McGaw Medical Center of Northwestern University, Chicago, IL
Surgery residency: McGaw Medical Center of Northwestern University, Chicago, IL
Urology residency: McGaw Medical Center of Northwestern University, Chicago, IL
Research fellow: Cancer Metastasis & Treatment Laboratory, NCI-Frederick Cancer Research Facility, Frederick, MD

Selected Publications
The following publications are selected from a complete CV.  For more information on Dr. Kozlowski's scholarly productivity, please contact his office.

Journal Articles

1. Fong CJ, Sutkowski DM, Kozlowski JM, Lee C. Utilization of the Boyden chamber to further characterize in vitro migration and invasion of benign and malignant human prostatic epithelial cells. Invasion Metastasis. 12(5-6):264-74. 1992.
2. Lee C, Shevrin DH, Kozlowski JM. In vivo and in vitro approaches to study metastasis in human prostatic cancer. Cancer Metastasis Rev. 12(1):21-8. 1993.
3. Lim DJ, Liu XL, Sutkowski DM, Braun EJ, Lee C, Kozlowski JM. Growth of an androgen-sensitive human prostate cancer cell line, LNCaP, in nude mice. Prostate. 22(2):109-18. 1993.
4. Sutkowski DM, Kasjanski RZ, Sensibar JA, Ney KG, Lim DJ, Kozlowski JM, Lee C, Grayhack JT. Effect of spermatocele fluid on growth of human prostatic cells in culture. J Androl. 14(4):233-9. 1993.
5. Kuzel TM, Tallman MS, Shevrin D, Braud E, Kilton L, Johnson P, Kozlowski J, Vogelzang NJ, Blough R, Benson AB 3rd. A phase II study of continuous infusion 5-fluorouracil in advanced hormone refractory prostate cancer. An Illinois Cancer Center Study. Cancer. 72(6):1965-8. 1993. 
6. Shankey TV, Kallioniemi OP, Kozlowski JM, Lieber ML, Mayall BH, Miller G, Smith GJ. Consensus review of the clinical utility of DNA content cytometry in prostate cancer. Cytometry. 14:497-500. 1993.
7. Crawford ED, Kozlowski JM, Debruyne FM, Fair WR, Logothetis CP, Balmer C, Robinson RG, Porter AT, Kirk D. The use of strontium 89 for palliation of pain from bone metastases associated with hormone-refractory prostate cancer. Urology. 44(4):481-5. 1994.
8. Lee C, Sutkowski DM, Sensibar JA, Zelner D, Kim I, Amsel I, Shaw N, Prins GS, Kozlowski JM. Regulation of proliferation and production of prostate-specific antigen in androgen-sensitive prostatic cancer cells, LNCaP, by dihydrotestosterone. Endocrinology. 136(2):796-803. 1995.
9. Sensibar JA, Sutkowski DM, Raffo A, Buttyan R, Griswold MD, Sylvester SR, Kozlowski JM, Lee C. Prevention of cell death induced by tumor necrosis factor alpha in LNCaP cells by overexpression of sulfated glycoprotein-2 (clusterin). Cancer Res. 55(11):2431-7. 1995.
10. Lee C, Grayhack JT, Kozlowski JM. Intrinsic and extrinsic factors controlling benign prostatic growth. Prostate. 31(2):131-8. 1997.
11. Williams BJ, Jones E, Kozlowski JM, Vessella R, Brothman AR. Comparative genomic hybridization and molecular cytogenetic characterization of two prostate cancer xenografts. Genes Chromosomes Cancer. 18(4):299-304. 1997.
12. Steinberg J, Oyasu R, Lang S, Rademaker A, Lee C, Kozlowski JM, Sensibar JA. Intracellular levels of SGP-2 (Clusterin) correlate with tumor grade in prostate cancer. Clin Cancer Res. 3(10):1707-11. 1997.
13. Grayhack JT, Kozlowski JM, Lee C. The pathogenesis of benign prostatic hyperplasia: a proposed hypothesis and critical evaluation. J Urol. 160(6 Pt 2):2375-80. 1998.
14. Sensibar JA, Pruden SJ, Kasjanski RZ, Rademaker A, Lee C, Grayhack JT, Kozlowski JM. Differential growth rates in stromal cultures of human prostate derived from patients of varying ages. Prostate. 38(2):110-7. 1999.
15. Sintich S, Steinberg J, Kozlowski JM, Lee C, Pruden S, Sayeed S, Sensibar JA. Cytotoxic sensitivity to tumor necrosis factor-alpha in PC3 and LNCaP prostatic cancer cells is regulated by extracellular levels of SGP-2 (clusterin). Prostate. 39(2):87-93. 1999.
16. Sherwood ER, Van Dongel JL, Wood CG, Liao S, Kozlowski JM, Lee C. Epidermal growth factor receptor activation in androgen-independent but not androgen-stimulated growth of human prostatic carcinoma cells. Br J Cancer. 77(6):855-61. 1998.
17. Grayhack JT, Sensibar HA, Ilio KY, Kasjanski RZ, Kozlowski JM, Lee C. Synergistic action of steroids and spermatocele fluid on in vitro proliferation of prostate stroma. J Urol. 159(6):2202-9. 1998.
18. Kim IY, Ahn HJ, Lang S, Oefelein MG, Oyasu R, Kozlowski JM, Lee C. Loss of expression of transforming growth factor-beta receptors is associated with poor prognosis in prostate cancer patients. Clin Cancer Res. 4(7):1625-30. 1998.
19. Cai X, Haleem R, Oram S, Cyriac J, Jiang F, Grayhack JT, Kozlowski JM, Wang Z. High fat diet increases the weight of rat ventral prostate. Prostate. 49(1):1-8. 2001.
20. Ilio KY, Park KI, Pins MR, Kozlowski JM, Lee C. Apoptotic activity of doxazosin on prostate stroma in vitro is mediated through an autocrine expression of TGF-beta1. Prostate. 48(3):131-5. 2001.
21. Abasolo I, Yang L, Haleem R, Xiao W, Pio R, Cuttitta F, Montuenga LM, Kozlowski JM, Calvo A, Wang Z. Overexpression of adrenomedullin gene markedly inhibits proliferation of PC3 prostate cancer cells in vitro and in vivo. Mol Cell Endocrinol. 199(1-2):179-87. 2003.
22. Xiao W, Zhang Q, Jiang F, Pins M, Kozlowski JM, Wang Z. Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer. Cancer Res. 63(15): 4698-704. 2003.
23. Zhou W, Park I, Pins M, Kozlowski JM, Jovanovic B, Zhang J, Lee C, Ilio K. Dual regulation of proliferation and growth arrest in prostatic stromal cells by transforming growth factor-beta1. Endocrinology. 144(10):4280-4. 2003.
24. Grayhack JT, Smith ND, Ilio K, Wambi C, Kasjanski R, Crawford SE, Doll JA, Wang Z, Lee C, Kozlowski JM. Pigment epithelium-derived factor, a human testis epididymis secretory product, promotes human prostate stromal cell growth in culture. J Urol. 171(1):434-8. 2004.
25. Pins MR, Fiadjoe JE, Korley F, Wong M, Rademaker AW, Jovanovic B, Yoo TK, Kozlowski JM, Raji A, Yang XJ, Lee C. Clusterin as a possible predictor for biochemical recurrence of prostate cancer following radical prostatectomy with intermediate Gleason scores: a preliminary report. Prostate Cancer Prostatic Dis. 7(3):243-8. 2004.

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