Sergey M. Troyanovsky, PhD

Associate Professor of Dermatology and
Molecular and Cellular Biology

Research Interests

Dr. Troyanovsky's research focuses on cadherin, intercellular adhesion, and signaling. Classic cadherins are critical proteins mediating cell-cell adhesion and various signaling pathways responsible for cellular proliferation, differentiation, and morphogenesis.  Abnormalities in this system are causal factors in many pathologies, including cancer.  The molecular mechanisms of cadherin-based adhesion, however, are largely unknown.  How do cadherins establish the adhesion contact? How do they interact with the cytoskeleton? What are the signaling pathways they control? Our laboratory's work is centered around these questions. We are currently working on the following specific projects:

• Cadherin -y-secretase interactions:  roles in cell-cell adhesion, notch signaling and amyloid processing

• Mechanisms of cadherins inactivation during tumor progression

• Live imaging of cadherin endocytosis

• Cadherin interactions with other transmembrane cellular receptors