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Biography Dr. Irina Budunova is an Associate Professor of Dermatology at Northwestern. She received her medical degree from N.N. Pirogov Medical Institute in Moscow and her Ph.D. in experimental Oncology from the Department of Chemical Carcinogenesis of the National Cancer Research Center in Moscow, where she served as a Scientist until emigrating to the Unites States in 1992. She became a faculty member at MD Anderson Cancer Center in Houston and later at the AMC Cancer Research Center in Denver. She moved to Northwestern as an Associate Professor of Dermatology in 2003. She is an expert on cell gap junctions, carcinogenesis and glucocorticoids receptors, and has published approximately 50 papers and chapters on these subjects. Research Interests Dr. Budunova's research interests include alteration of cell signaling and intercellular communications in tumorigenesis. She is also interested in the development of new approaches to prevention and adjuvant therapy of cancer. Specifically she focuses on: 1. Role of transcription factors such as glucocorticoid receptor and NF-kB transcription factors in skin and prostate tumorigenesis, cell proliferation and apoptosis. Cross-talk between different signaling pathways in tumorigenesis. 2. Link between skin epidermal stem cells and skin carcinogenesis. Regulation of stem cells by glucocorticoid hormones. 3. Role of gap junctional intercellular communication and connexin genes in the regulation of keratinocyte proliferation and transformation. 4. Translational research. Blockage of one of the central anti-apoptotic pathways mediated by NF-kB transcription factor and upstream kinases to increase the efficacy of chemotherapeutical treatments of prostate carcinomas.
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