ATC Abstracts & Presentations

Below are our contributions from our team for ATC 2024. 

| Invited Presentations |

Andres Duarte-Rojo, MD, MS, PhD

• In-Depth Presentation: Lifestyle modification for management of MASLD: a help or a hindrance?
  • Saturday June 1, 1:30PM - 1:50PM EST 

Josh Levitsky, MD, MS

• Presidential Address 
  • Sunday June 2, 9:45AM - 10:15AM EST 
• Special Session: AST Update 
  
  • Tuesday June 4, 11:45AM - 12:00PM EST 

Anat Tambur, PhD, DMD

• Hot Topic Debate Presentation: Expanding virtual crossmatch for DDKT - caution is advised! 
  • Monday June 3, 2:10PM - 2:30PM EST 

| Moderators |

Akansha Agrawal, MD

• Rapid Fire Oral Abstract Session - Kidney Desensitization and Immune Graft Failure
  • Tuesday June 4, 9:45AM - 10:45AM EST
• Rapid Fire Oral Abstract Session - Kidney Immunosuppression: Desensitization
  • Wednesday June 5, 9:30AM - 10:30AM EST

Mohammed Javeed Ansari, MD

• Rapid Fire Oral Abstract Session - Kidney Immunosuppression: Induction Therapy
  • Tuesday June 4, 9:45AM - 10:45AM EST 

Daniel Borja-Cacho, MD

• Rapid Fire Oral Abstract Session - Machine Perfusion and Organ Rehabilitation - Basic
  • Tuesday June 4, 3:00PM - 4:00PM EST 

Hazel Domingo, MMSc, PA-C

• Interactive Symposium - Maximizing Efficiency and Collaboration: The Integral Role of Advanced Practice Providers in Organ Procurement and Transplant Surgery
  • Sunday June 2, 1:30PM - 2:30PM EST 

John Friedewald, MD, FAST 

• Plenary Oral Abstract Session 4
  
  • Wednesday June 5, 8:15AM - 9:15AM EST

Josh Levitsky, MD, MS

• Plenary Oral Abstract Session 1
  • Sunday June 2, 8:15AM - 9:15AM EST

Satish Nadig, MD, PhD

• Interactive Symposium - Cells on a Diet! The Impact of Diet on the Alloimmune Response
  • Sunday June 2, 7:00AM - 8:00AM EST 

Sook Park, MD, MSCI

• Rapid Fire Oral Abstract Session - Kidney Living Donor: Other
  
  • Sunday June 2, 4:30PM - 5:30PM EST 

Vinayak Rohan, MD, FACS

• Rapid Fire Oral Abstract Session - Kidney Deceased Donor Allocation - 2
  • Wednesday June 5, 9:30AM - 10:30AM EST 

Jes Sanders, MD 

• Rapid Fire Oral Abstract Session - Treg Other Regulatory Cell Tolerance - 1
  • Saturday June 1, 4:30PM - 5:30PM EST

Zheng Zhang, MD, MSc 

• Rapid Fire Oral Abstract Session - Chronic Organ Rejection
  • Monday June 3, 4:30PM - 5:30PM EST 

| Plenary Oral Abstracts |

Fifteen Year Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients

• J. R. Leventhal{1}, J. Mehta{2}, J. Mathew{3}, L. Gallon{4}, A. Agrawal{3}, A. Tambur{3}, K. Ravindra{5}, M. Horwitz{6}, S. Ildstad{7}, {1}Surgery, Northwestern Medicine, Chicago, IL, {2}Stem Cell Transplantation and Cell Therapy, Northwestern Medicine, Chicago, IL, {3}Northwestern University, Chicago, IL, {4}Northwestern University NMFF, Chicago, IL, {5}Duke University Medical Center, Durham, NC, {6}Duke University, Durham, NC, {7}University of Louisville, Louisville, KY

| Rapid Oral Abstracts |

Combining Blood Gene Expression, Plasma Cellfree DNA, and Urine Chemokines to Diagnose Rejection in Kidney Transplant Recipients

• J. Friedewald{1}, L. Zhao{1}, S. Park{1}, M. Abecassis{2}, V. LaCombe{3}, G. Hanna{3}, B. Robelly{1}, C. Rebello{1}, T. Whisenant{4}, S. Kurian{5}, S. Kleiboeker{3};
  {1}Northwestern University, Chicago, IL, {2}University of Arizona, Tucson, AZ, {3}Eurofins - Viracor, Lenexa, KS, {4}UCSD, San Diego, CA, {5}Scripps, San Diego, CA

Social Deprivation Decreases Time to First Decompensation for Patients with Cirrhosis

• J. E. Obayemi{1}, M. Paukner{1}, B. J. Hasjim{1}, A. Jain{2}, F. Crippa{2}, K. N. Kershaw{1}, T. Banea{3}, P. Advani{4}, E. Koep{4}, Y. Akintola{4}, L. B. VanWagner{5}, L. Zhao{1}, C. F. Manski{2}, D. P. Ladner{1}, {1}Northwestern University Feinberg School of Medicine, Chicago, IL, {2}Northwestern University, Evanston, IL, {3}Northwestern University, Chicago, IL, {4}UnitedHealth Group, Minneapolis, MN, {5}UT Southwestern Medical Center, Dallas, TX

Virtual Liver Transplant Games (VLTG): Leveraging Technology and Gamification to Promote Physical Activity in End-Stage Liver Disease Patients

• A. Duarte-Rojo{1}, J. G. Stine{2}, B. M. Al-Judaibi{3}, M. S. Kriss{4}, P. M. Bloomer{5}, A. Tevar{5}, A. Desai{6}, M. R. Kappus{7}, J. Lai{8}, M. R. Porwit{1}, K. C. Specth{9}, M. E. Michta{9}, A. J. Thuluvath{1}, A. Daud{1}, D. P. Ladner{1}, E. D. Bethea{9}, {1}Northwestern, Chicago, IL, {2}Penn State U., Hershey, PA, {3}U. of Rochester, Rochester, NY, {4}U. of Colorado, Aurora, CO, {5}UPMC, Pittsburgh, PA, {6}Indiana U. School of Medicine, Indianapolis, IN, {7}Duke U. Health System, Raleigh, NC, {8}UCSF, San Francisco, CA, {9}Mass General Hospital, Cambridge, MA

A Home-Based Liver Frailty Intervention (LIFT) in Transplant Candidates: A Feasibility Study

• A. J. Thuluvath{1}, P. Polineni{2}, S. Morrissey{3}, K. Belfanti{3}, M. Nizamuddin{2}, O. Siddiqui{2}, A. Daud{2}, D. Simpson{2}, J. Levitsky{1}, A. Flores{3}, A. Duarte-Rojo{1}, D. P. Ladner{2}, {1}Division of Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL, {2}Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, {3}Department of Physical Therapy and Human Movement Science, Northwestern University Feinberg School of Medicine, Chicago, IL

The TAKE IT Trial: An EHR-Based Surveillance Strategy to Promote Medication Adherence among Kidney Transplant Recipients

• P. Zheng{1}, L. Curtis{1}, S. Hur{1}, M. Kwasny{1}, M. Serper{2}, S. Nair{3}, D. Ladner{4}, M. Wolf{1}, {1}Northwestern University, Chicago, IL, {2}University of Pennsylvania, Philadelphia, PA, {3}Mayo Clinic, Phoenix, AZ, {4}Northwestern Memorial Hospital, Chicago, IL

A Kidney Allograft Rejection Prediction Model Using Serial Gene Expression Profile and Donor-Derived Cell-Free DNA

• L. Zhao, C. Rebello, J. Friedewald, K. Guo, S. Park, Northwestern University, Chicago, IL

Poor Calibration of Allocation Priority Weights for Sensitized Patients Significantly Impacts Equitable Access to Kidney Transplantation in the United States

• J. Schold{1}, A.R. Tambur{2}, S. Mohan{3}, B. Kaplan{4}, {1}Surgery and Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, {2}Northwestern University, Chicago, IL, {3}Medicine, Columbia University, New York, NY, {4}Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO

Risk HLA-DQ Heterodimer Mismatch is Associated with De Novo Donor Specific Antibodies in Pediatric Kidney Transplant Recipients

• V. Sigurjonsdottir{1}, K. Piburn{2}, L. Wang{3}, P. Grimm{3}, A. R. Tambur{4}, B. M. Zhang{3}, {1}University of Miami, Miami, FL, {2}University of Texas Health, San Antonio, TX, {3}Stanford University, Stanford, CA, {4}Northwestern University, Chicago, IL

Are All Eplets Created Equal - Is It Quantity of Quality That Matters?

• E. Lazar-Molnar{1}, A. R. Tambur{2}, D. Jain{1}, Z. Zafar{3}, D. Morris{3}, S. Anand{3}, {1}University of Utah School of Medicine, Salt Lake City, UT, {2}Northwestern University, Chicago, IL, {3}Intermountain Medical Center, Salt Lake City, UT

HLA Eplet Matching as a Prognostic Biomarker of Kidney Transplant Outcomes

• M. Raynaud{1}, Z. Demir{1}, K. Louis{2}, A. Truchot{1}, A. Zeevi{3}, R. Ponsirenas{4}, A. R. Tambur{5}, C. Lefaucheur{2}, A. Loupy{1}, {1}Paris Transplant Group, Paris, France, {2}Saint-Louis Hospital, Paris, France, {3}University of Pittsburgh Medical Center, Pittsburgh, PA, {4}Hospital Universitário Cajuru, Curitiba, Brazil, {5}Northwestern University, Chicago, IL

Kidney Function Recovery after Liver Transplantation: The Contrasting Roles of Inflammation and Tubular Repair

• N. Goerlich{1}, S. Kim-Schulze{2}, P. Kotanko{3}, N. Grobe{3}, X. Wang{3}, P. Enghard{4}, M. Fribourg{2}, P. Cravedi{1}, J. Levitsky{5}, {1}Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY, {2}Icahn School of Medicine at Mount Sinai, New York, NY, {3}Renal Research Institute, New York, NY, {4}Charité Universitaetsmedizin Berlin, Berlin, Germany, {5}Northwestern University Feinberg School of Medicine, Chicago, IL

Torque Teno Virus Kinetics as a Measure of Net Immunosuppression in Kidney Transplant Recipients

• L. Speroni{1}, N. Ahmed{2}, R. Sinha{3}, K. Guo{2}, L. Zhao{2}, C. Rebello{2}, S. Kleiboeker{3}, A. Desai{2}, B. Kinsella{2}, J. Friedewald{2}, {1}Chapman University, Orange, CA, {2}Northwestern University, Chicago, IL, {3}Eurofins - Viracor, Lenexa, KS

Living Donor Candidates’ Use of a Chatbot on APOL1 to Scale up Genetic Testing in Clinical Evaluation

• E. J. Gordon{1}, J. Gacki-Smith{2}, D. Manning{2}, R. Yacat{3}, D. Jahangir{2}, D. Boachie{2}, T. Hall{3}, T. Truong{3}, C. Wicklund{4}, D. Duquette{2}, J. Friedewald{5}, A. Gilbert{3}, A. Agrawal{5}, {1}Surgery, Vanderbilt University Medical Center, Oak Park, IL, {2}Northwestern University Feinberg School of Medicine, Chicago, IL, {3}Georgetown University, Washington, DC, {4}Myriad, Chicago, IL, {5}Northwestern University, Chicago, IL

Beneficial Impact of CCR5 Blockade in Kidney Transplant Recipients with HIV

• A. Brown{1}, B. Barin{2}, G. Roll{3}, S. Mehta{4}, S. Florman{5}, C. Durand{6}, T. Pearson{7}, M. Cooper{8}, V. Stosor{9}, E. Blumberg{10}, J. Husson{11}, S. Bunnapradist{12}, T. J. Henrich{1}, Z. Laszik{1}, M. Sarwal{1}, B. Alston-Smith{13}, J. Odim{14}, R. Rogers{1}, P. Stock{1}, {1}UCSF, San Francisco, CA, {2}Emmes, Rockville, MD, {3}Transplant Surgery, UCSF, San Francisco, CA, {4}UAB, Birmingham, AL, {5}Transplant Surgery, Mt Sinai, New York, NY, {6}JHU, Baltimore, MD, {7}Emory, Atlanta, GA, {8}Georgetown, Washington, DC, {9}Northwestern, Chicago, IL, {10}UPenn, Philadelphia, PA, {11}UMD, Baltimore, MD, {12}UCLA, Los Angeles, CA, {13}NIH NIAID, Rockville, MD, {14}NIH DAIT, Rockville, MD

Increased Rate of Deceased Donor Liver Transplant Rate for Candidates Willing to Receive Organs from Donors with HIV

• Z. Nauroz{1}, M. Bowring{1}, S. Florman{2}, M. Rana{2}, J. Motter{3}, J. Price{4}, S. Mehta{3}, J. Hand{5}, D. Wojciechowski{6}, S. Aslam{7}, M. Malinis{8}, N. Elias{9}, G. Haidar{10}, M. Pereira{11}, J. Simkins{12}, V. Stosor{13}, C. Small{14}, J. Baddley{15}, M. Morsheimer{16}, D. Segev{3}, A. Massie{3}, C. Durand{1}, {1}JHU, Baltimore, MD, {2}Sinai, NYC, NY, {3}NYU, NYC, NY, {4}UCSF, San Francisco, CA, {5}Ochsner, New Orleans, LA, {6}UTSW, Dallas, TX, {7}UCSD, San Diego, CA, {8}Yale, New Haven, CT, {9}MGH, Milton, MA, {10}UPMC, Pittsburgh, PA, {11}Columbia, NYC, NY, {12}Univ of Miami, Miami, FL, {13}Northwestern, Chicago, IL, {14}Cornell, NYC, NY, {15}UMD, Baltimore, MD, {16}NIH, Rockville, MD

Kaposi Sarcoma-Associated Herpesvirus Seroprevalence and Disease in Kidney Transplant Recipients with HIV under the HOPE Act

• T. Liang{1}, P. Nambiar{2}, M. Rana{3}, S. Florman{3}, M. Bowring{1}, W. Werbel{1}, N. Labo{4}, D. Whitby{4}, R. Friedman-Moraco{5}, P. Stock{6}, A. Gilbert{7}, S. Mehta{8}, V. Stosor{9}, S. Mehta{10}, M. Pereira{11}, C. Butkus Small{12}, M. Morris{13}, J. Hand{14}, S. Aslam{15}, J. Baddley{16}, G. Haidar{17}, M. Malinis{18}, C. Santos{19}, J. Schaenman{20}, R. La Hoz{21}, E. Blumberg{22}, N. Elias{23}, E. Giorgakis{24}, D. Segev{10}, C. Durand{1}, {1}JHU, Baltimore, MD, {2}Medicine, MSKCC, New York, NY, {3}Mt Sinai, NYC, NY, {4}NCI, Frederick, MD, {5}Emory, Atlanta, GA, {6}UCSF, San Francisco, CA, {7}Georgetown, Washington, DC, {8}UABMC, Birmingham, AL, {9}NW Univ, Chicago, IL, {10}NYU, NYC, NY, {11}Columbia, NYC, NY, {12}Cornell, NYC, NY, {13}Univ of Miami, Miami, FL, {14}Ochsner, New Orleans, LA, {15}UCSD, San Diego, CA, {16}UMD, Baltimore, MD, {17}UPMC, Pittsburgh, PA, {18}Yale, New Haven, CT, {19}Rush, Chicago, IL, {20}UCLA, Los Angeles, CA, {21}UTSW, Dallas, TX, {22}UPenn, Philadelphia, PA, {23}MGH, Boston, MA, {24}UAMS, Little Rock, AR

Risk of Viral Infections in Solid Organ Transplant Recipients Receiving Belatacept: A Systematic Review and Meta-Analysis

• I. Tawhari{1}, F. Yamani{2}, {1}Internal Medicine, Nephrology, King Khalid University, Abha, Saudi Arabia, {2}Northwestern Memorial Hospital, Chicago, IL

Developing Clinical Case Studies to Prepare Transplant Teams for First-in-Human Pig Xenotransplant Clinical Trials

• M. K. Gusmano{1}, K. Maschke{2}, J. Gacki-Smith{3}, M. Matthews{2}, B. Lopez-Patino{4}, K. Traboulsi{1}, D. Manning{3}, E. J. Gordon{5}, {1}Lehigh University, Bethlehem, PA, {2}The Hastings Center, Garrison, NY, {3}Northwestern University, Chicago, IL, {4}The Hastings Center, Bethlehem, NY, {5}Surgery, Vanderbilt University Medical Center, Oak Park, IL

| Poster Abstracts |

You are what you eat: Harnessing the power of endothelial cell autophagy as a potential donor organ pre-treatment strategy in cardiac transplantation 

• M. E. Taylor, D. Jaishankar, L. Andrade da Silva, A. P. Strouse, Y. Lee, S. Nadig, Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL

Long-Term Mortality and Frailty Among Patients With Low MELD Cirrhosis, 2011-2021

• B. J. Hasjim{1}, M. Paukner{1}, M. Mohammadi{2}, J. E. Obayemi{1}, D. J. Vitello{1}, T. Banea{1}, L. B. VanWagner{3}, A. Duarte-Rojo{1}, L. Zhao{1}, S. Mehrotra{2}, D. P. Ladner{1}, {1}Northwestern University Feinberg School of Medicine, Chicago, IL, {2}Northwestern University, Evanston, IL, {3}UT Southwestern Medical Center, Dallas, TX

Cost Burden of Cirrhosis and Liver Transplantation in Privately Insured Patients in the US: 2011-2020

• B. J. Hasjim{1}, F. Obradović{2}, D. J. Vitello{1}, J. E. Obayemi{1}, A. Jain{2}, M. Gmeiner{3}, F. Crippa{2}, A. Duarte-Rojo{4}, L. Kulik{4}, T. Banea{1}, L. Zhao{5}, L. B. VanWagner{6}, C. F. Manski{2}, D. P. Ladner{1}, {1}Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, {2}Department of Economics, Northwestern University, Evanston, IL, {3}London School of Economics, London, United Kingdom, {4}Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, {5}Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, {6}Department of Medicine, UT Southwestern Medical Center, Dallas, TX

Rates Of Secondary Prevention Of Variceal Bleeding Differ By Race And Ethnicity

• J. E. Obayemi{1}, M. Paukner{2}, B. J. Hasjim{1}, M. Mohammadi{3}, D. J. Vitello{1}, T. Banea{1}, L. B. VanWagner{4}, A. Duarte-Rojo{5}, L. Zhao{2}, S. Mehrotra{6}, D. P. Ladner{1}, {1}Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, {2}Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, {3}Industrial Engineering and Management Sciences, Northwestern University, Chicago, IL, {4}Medicine, University of Texas Southwestern Medical Center, Dallas, TX, {5}Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, {6}Industrial Engineering and Management Sciences, Northwestern University, Evanston, IL

Prevention Of Recurrent Variceal Bleeding Is Low Among Patients With ALD Cirrhosis

• J. E. Obayemi{1}, M. Paukner{2}, B. J. Hasjim{1}, M. Mohammadi{3}, D. J. Vitello{1}, T. Banea{4}, L. B. VanWagner{5}, A. Duarte-Rojo{6}, L. Zhao{2}, S. Mehrotra{7}, D. P. Ladner{1}, {1}Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, {2}Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, {3}Industrial Engineering and Management Sciences, Northwestern University Feinberg School of Medicine, Evanston, IL, {4}Northwestern University, Chicago, IL, {5}Medicine, University of Texas Southwestern Medical Center, Dallas, TX, {6}Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, {7}Industrial Engineering and Management Sciences, Northwestern University, Evanston, IL

Pre-Transplant and Early Post-Transplant CD8+ Donor Reactive Clones May Predispose to Rejection in Kidney Transplant Recipients Receiving Non-Lymphodepletional Induction

• J. M. Sanders{1}, B. L. Banbury{2}, E. L. Schumacher{2}, J. He{1}, J. R. Leventhal{1}, J. M. Mathew{1}, {1}Department of Surgery, Northwestern University, Chicago, IL, {2}Adaptive Biotechnologies, Seattle, WA

A Phase 2 Study of Regulatory T Cell Therapy to Achieve Immunosuppression (IS) Reduction in Living Donor Kidney Transplant (LDKTx) Recipients: The RETIRE Trial

• J. R. Leventhal{1}, C. Stratton{2}, J. Mathew{3}, C. Yang{4}, S. Murray{2}, {1}SURGERY, Northwestern Medicine, Chicago, IL, {2}TRACT Therapeutics, Chicago, IL, {3}Northwestern University, Chicago, IL, {4}Taiwan Bio, Taipei, Taiwan

Single Center Experience with the FREEDOM 1 Trial (NCT03995901), a Randomized Controlled Study to Evaluate the Safety, Efficacy, and Overall Benefit of FCR001 Cell Therapy in De Novo Living Donor Renal Transplantation

• J. R. Leventhal{1}, J. Mehta{2}, L. Gallon{1}, A. Agrawal{1}, J. Mathew{1}, S. Ildstad{3}, {1}Northwestern, Chicago, IL, {2}Stem Cell Transplantation and Cell Therapy, Northwestern Medicine, Chicago, IL, {3}University of Louisville, Louisville, KY

Real World Experience of Combining Blood Gene Expression and Donor-Derived Cell-Free DNA for Diagnosing Kidney Allograft Rejection

• S. Park{1}, K. Guo{1}, L. Zhao{2}, S. Kleiboeker{3}, J. Friedewald{1}, {1}Northwestern University, Chicago, IL, {2}Northwestern University, chicago, IL, {3}Viracor Eurofins, Lees Summit, MO

Unfolded Protein Response in Myeloid Cells Controls Tubular Epithelial Regeneration of Renal Allograft via TWEAK-Fn14 Signaling Pathway

• J. Cai, X. Zheng, W. Yuen, J. Wang, L. VanOsdol, Z. J. Zhang, Comprehensive Transplant Center and Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL

Utilization of A2 and A2B to B Kidney Transplantation among Transplant Centers with Large Black Patient Populations

• K. Atiemo{1}, E. Oguntuwase{2}, D. Ladner{3}, {1}Weill Cornell Surgery, NY, NY, {2}Weill Cornell, NY, NY, {3}Northwestern Memorial Hospital, Chicago, IL

Association of Immunosuppression Status as Defined by Torque Teno Virus Load and Clinical Outcomes in Kidney Transplant Recipients

• N. Ahmed{1}, L. Speroni{2}, K. Guo{2}, A. Desai{2}, C. Rebello{2}, S. Kleiboeker{2}, B. Kinsella{2}, J. Friedewald{2}, A. Desai{2}, {1}Arizona College of Osteopathic Medicine, Glendale, AZ, {2}Northwestern University, Chicago, IL

Changes in Peripheral Blood Gene Expression and Cell Type Abundance during Treatment for Acute Rejection in Kidney Transplant Recipients

• T. Whisenant{1}, C. Rebello{2}, K. Guo{2}, S. Park{2}, L. Zhao{2}, M. Abecassis{3}, J. Friedewald{2}, {1}UCSD, San Diego, CA, {2}Northwestern University, Chicago, IL, {3}University of Arizona, Tucson, AZ

Sociodemographic Correlates of Barriers to Progression from Living Donor Candidate Evaluation to Donor Approval: Analysis of the SRTR Living Donor Collective

• K. L. Lentine{1}, A. Hart{2}, Y. Ahn{3}, D. Brennan{4}, P. Dean{5}, M. Doshi{6}, A. Duarte{7}, G. Katz-Greenberg{8}, E. King{9}, M. Levan{10}, A. Matas{11}, D. LaPointe-Rudow{12}, W. McKinney{2}, H. Xiao{1}, C. Wooley{1}, K. Siegert{3}, C. Nystedt{3}, A. Israni{2}, J. Synder{3}, A. Waterman{13}, {1}Saint Louis Univ, St. Louis, MO, {2}Hennepin Health, Minneapolis, MN, {3}SRTR, Minneapolis, MN, {4}Johns Hopkins, Baltimore, MD, {5}Mayo Clinic, Rochester, MN, {6}Univ. Michigan, Ann Arbor, MI, {7}Northwestern, Chicago, IL, {8}Duke, Durham, NC, {9}John Hopkins, Baltimore, MD, {10}NYU, New York, NY, {11}U Minnesota, Minneapolis, MN, {12}Mount Sinai, New York, NY, {13}Houston Methodist, Houston, TX

“Loss Aversion” and Framing Choices about the Use of XTx Pig Kidneys

• M. K. Gusmano{1}, E. J. Gordon{2}, J. Gacki-Smith{3}, M. Matthews{4}, B. Lopez-Patino{4}, E. Randolph{1}, D. Manning{3}, K. Maschke{4}, {1}Lehigh University, Bethlehem, PA, {2}Surgery, Vanderbilt University Medical Center, Oak Park, IL, {3}Northwestern University, Chicago, IL, {4}The Hastings Center, Garrison, NY

Challenges to Monitoring Living Donor Candidates Long Term: Understanding Mobility of Living Donors in the Living Donor Collective

• Y. Ahn{1}, A. Israni{2}, W. McKinney{2}, D. Schladt{1}, C. Nystedt{1}, C. Mejia{3}, A. Duarte{4}, A. Matas{5}, D. L. Rudow{6}, E. McMahon{7}, M. Doshi{8}, P. Dean{9}, G. Katz-Greenberg{10}, J. Snyder{11}, A. Waterman{12}, K. Lentine{13}, {1}SRTR, Minneapolis, MN, {2}Hennepin Healthcare, Univ of MN, Minneapolis, MN, {3}Johns Hopkins, Baltimore, MD, {4}Northwestern, Chicago, IL, {5}Univ of MN, Minneapolis, MN, {6}Mount Sinai Hospital, New York, NY, {7}Univ of Pittsburgh, Pittsburgh, PA, {8}Univ of Michigan, Ann Arbor, MI, {9}Mayo Clinic, Rochester, MN, {10}Duke Univ, Durham, NC, {11}HHRI, Minneapolis, MN, {12}Houston Methodist Hospital, Houston, TX, {13}Saint Louis Univ, St. Louis, MO

Below are our contributions from our team for ATC 2023.

| Presentations: In-Depth, IMPACT, & Meet the Expert |

Juan Caicedo, MD

• Approach to the Living Liver Donor with Steatosis
• Racial and Ethnic Disparities: What We Know, Don’t Know, and What We Can Do About it

Akansha Agrawal, MD

• Evaluation of Genetic Kidney Diseases in Living Donor Candidates When Related Recipient Diagnosis is Known (e.g. ADPKD, COL4 Nephropathies, Fabry Disease)

John Franklin, MD

• A Culturally Tailored Program for African Americans

Dinee Simpson, MD

• The Road to Equity: Developing Health System Interventions to Narrow Disparities in Solid Organ Transplantation

Anat Tambur, PhD DMD

• Down to the Details: Potential Pitfalls and Limitations of HLA-Epitope Matching

Rebecca Duke, DNP MSN APRN-CNP

• Nursing Burnout in Transplant

James Mathew, PhD

• Non-invasive Diagnosis of Rejections in Blood and Urine by Monitoring Donor Reactive T Cell Clones

Joseph Leventhal, MD PhD FACS

• Utility of Blood Chimerism for Monitoring and Detection of Graft Versus Host Disease in SOT

Vikram Aggarwal, MD DNB

• Destination Dialysis: The ESRD Patient Ineligible for Kidney Transplant: Home-dialysis Therapies are the Next Best Option

Robert Lewandowski, MD FSIR

• Destination HCC Treatment: Ablation vs Radioembolization in the Non-transplantable HCC Patient

 

| Abstracts & Oral Presentations |

Long-term mortality prediction in patients with cirrhosis with laboratory data: comparisons of multiple machine-learning methods

• A. A. Huang{1}, B. J. Hasjim{1}, P. Polineni{1}, M. M. Dehchesmeh{2}, S. L. Olson{1}, L. Zhao{1}, K. Guo{1}, J. Jung{1}, J. Doll{1}, T. Banea{1}, S. Mehrotra{2}, D. P. Ladner{1}, {1}Northwestern University Feinberg School of Medicine, Chicago, IL, {2}Northwestern University, Evanston, IL

• M. Meneghini{1}, A. Armstrong Antunes{1}, D. Isaacson{2}, C. Maguire{1}, A. Tambur{1}, {1}Transplant Immunology Laboratory, Northwestern University, Chicago, IL, {2}Urology, Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL

A Successful Double Lung and Kidney Transplant Despite Strongly Positive T and B-Cell Cross Match

• S. Metwally, J. Portocarrero Caceres, J. Friedewald, A. Desai, A. Agrawal, D. Pinelli, A. Tambur, A. Arunachalam, R. Tomic, A. Bharat, S. Nadig, M. Ansari, Northwestern University, Chicago, IL

HLA Molecular Mismatches and Induced Donor-Specific Tolerance in Kidney Transplantation

• A. Senev{1}, A. Tambur{2}, V. Kosmoliaptsis{3}, H. C. Copley{3}, S. Ildstad{4}, J. R. Leventhal{5}, {1}Comprehensive Transplant Center, Northwestern University, Chicago, IL, {2}Northwestern University, Chicago, IL, {3}University of Cambridge, Cambridge, United Kingdom, {4}University of Louisville, Louisville, KY, {5}Surgery, Northwestern Medicine, Chicago, IL

Improving Informed Consent for Living Liver Donors: What Information Do Donors Want About Their Recipient?

• A. Chen{1}, A. Carroll{1}, E. Gordon{2}, J. Levitsky{1}, {1}Northwestern University Feinberg School of Medicine, Chicago, IL, {2}Department of Surgery, Vanderbilt University Medical Center, Nashville, TN

Acute Cellular Rejection in Elderly Lung Transplant Recipients During First Year Post Transplant

• H. Kleiboeker{1}, C. Kane{1}, K. Paplaczyk{2}, J. Lysne{2}, A. Prom{1}, R. Tomic{2}, A. Arunachalam{3}, {1}Pharmacy, Northwestern Memorial Hospital, Chicago, IL, {2}Northwestern Memorial Hospital, Chicago, IL, {3}Northwestern University, Chicago, IL

Association of HLA Molecular Mismatch with Risk and Severity of Rejection in Kidney Transplant Recipients

• A. Kushner{1}, C. Rebello{1}, T. Whisenant{2}, A. Tambur{1}, S. Park{1}, K. Guo{1}, L. Zhao{1}, J. Friedewald{1}, {1}Northwestern University, Chicago, IL, {2}UCSD, San Diego, CA

Endothelial Connexin 43 Gap Junctions in Ischemia-Reperfusion Injury - Role and Therapeutic Implications for Solid Organ Transplantation

• D. Jaishankar, M. Taylor, Y. Lee, A. P. Strouse, S. N. Nadig, Northwestern University, Chicago, IL

Ex Vivo Preconditioning of Human Kidney with PHD Inhibitor Upregulates HIF Target Genes with a Goal to Mitigate Ischemia-Reperfusion Injury Prior to Transplant

• B. Y. Bishop{1}, R. Tiwari{2}, M. E. Taylor{2}, D. Jaishankar{2}, S. Nadig{1}, P. Kapitsinou{1}, {1}Feinberg School of Medicine at McGaw Medical Center, Northwestern University, Chicago, IL, {2}Northwestern University, Chicago, IL

Infectious Complications in Elderly Lung Transplant Recipients During First Year Post-Transplant

• H. Kleiboeker{1}, C. Kane{2}, J. Lysne{3}, K. Paplaczyk{3}, A. Prom{1}, R. Tomic{3}, A. Arunachalam{4}, {1}Pharmacy, Northwestern Memorial Hospital, Chicago, IL, {2}Pharmacy, Northwestern Memorial Hopsital, Chicago, IL, {3}Northwestern Memorial Hospital, Chicago, IL, {4}Northwestern University, Chicago, IL

Recipient Macrophage-Derived Xbp1 Mitigates Ischemia and Reperfusion Injury Mediated via Regulating TGFβ1/KLF4 Pathways Response Following Kidney Transplantation

• X. Zheng, S. Jeyamogan, C. Chen, L. VanOsdol, S. Han, Y. Han, J. Wang, J. Mathew, Z. J. Zhang, Comprehensive Transplant Center and Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL

The Xbp1s Agonist IXA4 Regulates Bile Acids in the Abcb4-knockout Model of Primary Sclerosing Cholangitis

• A. J. Benintende{1}, M. Naibryf{1}, B. LeCuyer{1}, E. Saez{2}, L. Wiseman{2}, R. M. Green{1}, {1}Northwestern University - Feinberg School of Medicine, Chicago, IL, {2}Molecular Medicine, Scripps Research, La Jolla, CA

Infectious Complications of Lung Transplant for Covid-Associated Lung Injury (cali): A Single Center Case-Control Cohort Study

• R. Osborn{1}, M. Alamri{2}, T. Rade{1}, M. Ison{3}, {1}Northwestern Memorial Hospital, Chicago, IL, {2}McGaw Medical Center of Northwestern University, Chicago, IL, {3}Northwestern University Feinberg School of Medicine, Chicago, IL

 Deciphering HLA-DQ Immunogenicity: A Small Step Forward

• C. Maguire{1}, P. Crivello{2}, S. Heidt{3}, V. Kosmoliaptsis{4}, A. Tambur{5}, {1}Transplant Immunology, Northwestern University, Chicago, IL, {2}UK-Essen, Essen, Germany, {3}Leiden Medical Center, Leiden, Netherlands, {4}U of Cambridge, Cambridge, United Kingdom, {5}Northwestern University, Chicago, IL

A Phase 2 Multi-Center, Prospective, Randomized, Double-Blind Study to Assess Efficacy and Safety of Nitazoxanide Treatment of Norovirus in Transplant Recipients

• C. Boutin{1}, M. A. Callegari{1}, D. Florescu{2}, M. Nguyen{2}, D. Kaul{2}, R. Avery{2}, P. Chong{2}, C. Fisher{2}, A. Limaye{2}, L. Clough{2}, S. Pergam{2}, M. Green{2}, M. Michaels{2}, L. Danziger-Isakov{2}, M. Angarone{1}, L. Keefer{2}, A. Daud{1}, M. Ison{1}, {1}Northwestern University FSM, Chicago, IL, {2}NNITS Study Group, Chicago, IL

Changes in Endothelial and Proximal Tubule Cells in Focal Segmental Glomerulosclerosis: Single-Cell Resolution of Human Renal Allografts with Recurrent Disease

• L. Gallon{1}, H. Zubair{2}, A. C. Shetty{2}, J. McDaniels{2}, T. Rousselle{2}, S. Azim{2}, C. Kuscu{3}, C. Kuscu{3}, J. Eason{4}, D. Maluf{5}, V. Mas{2}, {1}Northwestern University NMFF, Chicago, IL, {2}Surgical Sciences, University of Maryland, Baltimore, MD, {3}UTHSC, Memphis, TN, {4}James D. Eason Transplant Institute, Memphis, TN, {5}Program in Transplantation, University of Maryland, Baltimore, MD

Complications of Anticoagulation in Lung Transplant Recipients on Concurrent Azole Antifungal Therapy

• A. Rubino, K. Cunningham, C. D'Agostino, K. Paplaczyk, R. Arora, H. Kleiboeker, A. Prom, C. Kane, Northwestern Memorial Hospital, Chicago, IL

Assessment of BioFire® Pneumonia Panel Utility in Lung Transplant Recipients with Concern for Respiratory Infection 

• M. Alamri{1}, J. Moore{2}, S. Sutton{2}, M. Ison{3}, {1}McGaw Medical Center of Northwestern University, Chicago, IL, {2}Northwestern Memorial Hospital, Chicago, IL, {3}Northwestern University Feinberg School of Medicine, Chicago, IL

Clinical Course of Norovirus in Adult and Pediatric Solid Organ and Hematopoietic Stem Cell Transplant Recipients:a Multi-Center, Retrospective Study

• M. A. Callegari{1}, L. Danziger-Isakov{2}, A. Rose{2}, D. Kaul{2}, K. Shaffer{2}, P. Chong{2}, D. Florescu{2}, K. German{2}, R. Avery{2}, M. Nguyen{2}, B. Wildfeuer{2}, M. Michaels{2}, M. Green{2}, L. Zhao{3}, K. Guo{3}, A. Daud{3}, M. Ison{3}, {1}Northwestern University Feinberg School of Medicine, Chicago, IL, {2}NNITS Study Team, Chicago, IL, {3}Northwestern University FSM, Chicago, IL

In Vitro Differentiation of Hematopoietic Stem Cells Into Immunoregulatory T and Myeloid Cells Following Allogeneic Stimulation

• J. M. Sanders, J. R. Leventhal, J. M. Mathew, Surgery-Comprehensive Transplant Center, Northwestern University, Chicago, IL

Tolerogenic Potential of FOXP3+ Exosomes Derived from Alloantigen Specifically Expanded Regulatory T Cells

• S. Jeyamogan, J. Sanders, M. Gunasekaran, J. He, S. Kaushal, J. Leventhal, J. Mathew, Northwestern University, Chicago, IL

Utilization of Oral Step-Down Antiviral Therapy May Decrease Length of Hospital Admission for Resistant Cytomegalovirus After Solid Organ Transplant: A Real World Case Series

• H. Kleiboeker{1}, J. Fose{2}, L. T. Schulz{2}, D. Mandelbrot{2}, J. Odorico{3}, C. Saddler{4}, J. Smith{4}, M. Jorgenson{5}, {1}Pharmacy, Northwestern Memorial Hospital, Chicago, IL, {2}UW Health, Madison, WI, {3}University of Wisconsin Hospital & Clinic, Madison, WI, {4}University of Wisconsin Infectious Disease, Madison, WI, {5}University of Wisconsin Health, Madison, WI

Multi-Institutional Validation of Automated AI Banff Lesion Score Predictions from Renal Allograft Biopsies

• L. A. Cooper{1}, A. B. Farris{2}, L. Allegretti{3}, D. A. Gutman{2}, C. Rebello{1}, J. Hogan{4}, J. Friedewald{1}, {1}Northwestern University, Chicago, IL, {2}Emory University, Atlanta, GA, {3}University of Wisconsin, Madison, WI, {4}Université de Paris, Paris, France

Community-Level Social Vulnerability and Liver Waitlisting and Transplantation of Cirrhosis Patients

• P. Polineni{1}, A. A. Huang{1}, R. Huang{1}, B. J. Hasjim{1}, K. Guo{1}, L. Zhao{1}, A. Furmanchuk{1}, M. M. Dehchesmeh{2}, M. W. Lewis-Thames{1}, L. M. McElroy{3}, D. C. Simpson{1}, S. Mehrotra{2}, L. B. VanWagner{4}, D. P. Ladner{1}, {1}Northwestern University Feinberg School of Medicine, Chicago, IL, {2}Northwestern University, Evanston, IL, {3}Duke University Medical Center, Durham, NC, {4}UT Southwestern Medical Center, Dallas, TX

Use of the Claims-Based Frailty Index for Pre-Transplant Mortality in Cirrhosis Patients with Low MELD-Na

• A. A. Huang{1}, S. L. Olson{1}, A. J. Thuluvath{1}, P. Polineni{1}, B. J. Hasjim{1}, A. M. Flores{1}, A. Duarte-Rojo{1}, J. Doll{1}, T. Banea{1}, S. Mehrotra{2}, D. P. Ladner{1}, {1}Northwestern University Feinberg School of Medicine, Chicago, IL, {2}Northwestern University, Evanston, IL

Where You Live Matters: Patients with Cirrhosis Living in More Deprived Neighborhoods are Associated with Lower Survival and Transplant Wait listing

• B. J. Hasjim{1}, A. A. Huang{1}, P. Polineni{1}, A. Harris{1}, M. M. Dehchesmeh{2}, M. Paukner{1}, K. N. Kershaw{1}, T. Banea{1}, L. B. VanWagner{3}, S. Mehrotra{2}, L. Zhao{1}, D. P. Ladner{1}, {1}Northwestern University Feinberg School of Medicine, Chicago, IL, {2}Northwestern University, Evanston, IL, {3}UT Southwestern Medical Center, Dallas, TX

Double Lung Transplant REgistry Aimed for Lung-Limited Malignancies (DREAM) - A Prospective Registry Study for Double Lung Transplantation for Medically Refractory Cancers Limited to the Lungs

• Y. Chae, L. Chung, R. Tomic, A. Bharat, Northwestern University, Chicago, IL

| Work In Collaboration |

Support Needs for Living Kidney Donor Candidates: Results from a Multicenter Qualitative Study

• A. Daley{1}, E. Alagoz{1}, J. Gannon{2}, S. Li{2}, D. Dobosz{2}, K. Kennedy{3}, D. Gray{4}, A. Mussell{4}, P. Reese{4}, E. Gordon{3}, S. Kulkarni{2}, C. Thiessen{1}, {1}University of Wisconsin, Madison, WI, {2}Yale University, New Haven, CT, {3}Northwestern University, Chicago, IL, {4}University of Pennsylvania, Philadelphia, PA

The First 58 Global Kidney Exchange Transplants: Overcoming Multiple Barriers to Transplantation

• M. Rees{1}, I. Marino{2}, A. A. Alobaidli{3}, S. Paloyo{4}, R. Sung{5}, A. Cohen{6}, L. BASAGOITIA GONZALEZ{7}, F. Citterio{8}, A. Roth{9}, O. Ekwenna{1}, J. R. Leventhal{10}, J. Hawksworth{11}, M. Ellis{12}, K. Krawiec{13}, T. Dunn{14}, {1}University of Toledo, Toledo, OH, {2}Jefferson, Roma, Italy, {3}Abu Dhabi Health Services Company, Abu Dhabi, United Arab Emirates, {4}Philippine General Hospital, Manila, Philippines, {5}University of Michigan Health System, Ann Arbor, MI, {6}Ochsner Health System, New Orleans, LA, {7}Pro Renal, Mexico City, Mexico, {8}Gemelli Hospital, Rome, Italy, {9}Standford University, Standford, CA, {10}SURGERY, Northwestern Medicine, Chicago, IL, {11}Walter Reed National Military Medical Center, Washington DC, DC, {12}Duke University Hospital, Durham, NC, {13}University of Virginia School of Law, Charlottesville, VA, {14}Hospital of the University of Pennsylvania, Philadelphia, PA

Cell-Free DNA Derived Temporal Dynamics and Trends of Torque Teno Virus in Kidney Transplant

• R. Sinha{1}, Z. Zhu{2}, J. Friedewald{3}, S. Kleiboeker{2}, {1}R&D, Viracor-Eurofins, Lenexa, KS, {2}Eurofins Viracor, Lenexa, KS, {3}Northwestern University, Chicago, IL

Do Hispanic Patients Complete Kidney Transplant Evaluation as Fast as Non-Hispanic White Patients?

• E. J. Gordon{1}, J. Lee{2}, R. Kang{2}, J. Uriarte{2}, J. Caicedo{2}, {1}Vanderbilt University Medical Center, Nashville, TN, {2}Northwestern University Feinberg School of Medicine, Chicago, IL

Expanding Donor Cause of Death Designations Reflects Changing Donor Population and Utilization Practices

• M. Adjei{1}, S. Wisel{2}, T. Todo{2}, G. Voidonikolas{2}, I. Kim{2}, J. Steggerda{2}, D. Borja-Cacho{3}, {1}Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, {2}Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, {3}Department of Surgery, Northwestern Memorial Hospital, Chicago, IL

Trends in Marginal Donor Utilization in the United States Across Solid Organ Transplant

• J. A. Steggerda{1}, D. Borja-Cacho{2}, S. A. Wisel{1}, D. P. Ladner{2}, T. Todo{3}, P. Catarino{4}, I. K. Kim{5}, {1}Transplant Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, {2}Transplant Surgery, Northwestern Memorial Hospital, Chicago, IL, {3}Transplant Surgery, Cedars Sinai Medical Center, Los Angeles, CA, {4}Cardiothoracic Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, {5}Transplant Surgery, Cedars-Sinai Medical Center, Los Angeles, Los Angeles, CA

Where Do Ethnic Disparities Arise in the Living Kidney Donor Evaluation Process?

• J. Uriarte{1}, S. Dong{1}, J. Lee{1}, R. Kang{1}, J. Figueroa{1}, J. Caicedo{1}, E. J. Gordon{2}, {1}Northwestern University Feinberg School of Medicine, Chicago, IL, {2}Vanderbilt University Medical Center, Nashville, IL

Association Between Hla Molecular Mismatch and Histological Rejection in Kidney Allograft

• M. Patel{1}, C. Rebello{2}, T. Whisenant{3}, K. Guo{2}, A. Tambur{2}, L. Zhao{2}, J. Friedewald{2}, S. Park{4}, {1}New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY, {2}Northwestern University, Chicago, IL, {3}University of California, San Diego, CA, {4}Northwestern University, CHICAGO, IL

Long-Term Outcomes of Conversion from Tacrolimus to Sirolimus in Kidney Transplant Recipients: An 8-Year Follow Up Study

• I. Tawhari{1}, S. Park{2}, F. Yamani{2}, A. Irshad{2}, L. Safar Boueri{2}, J. Ansari{2}, L. Gallon{2}, {1}King Khalid University, Abha, Saudi Arabia, {2}Northwestern University, Chicago, IL

Open Simultaneous Offers for High-KDRI Kidneys May Significantly Reduce Discards

• V. Kilambi{1}, M. Barah{2}, S. Dey{2}, S. Mehrotra{2}, {1}RAND Corporation, Arlington, VA, {2}Northwestern University, Evanston, IL

Polyclonal Treg Therapy for Renal Allograft Inflammation: Results of CTOT-21, A Randomized Controlled Clinical Trial

• S. Chandran{1}, Q. Tang{1}, J. C. Leung{1}, Z. Laszik{1}, B. Armstrong{2}, M. Morsheimer{3}, E. Farkash{4}, R. B. Mannon{5}, S. Davis{6}, J. Friedewald{7}, F. Vincenti{1}, {1}UCSF, San Francisco, CA, {2}Rho, Durham, NC, {3}DAIT, NIAID, Bethesda, MD, {4}U of Michigan, Ann Arbor, MI, {5}U of Nebraska, Omaha, NE, {6}U of Colorado, Denver, CO, {7}Northwestern U, Chicago, IL

Sodium Polystyrene Sulfonate vs Sodium Zirconium Cyclosilicate for Hyperkalemia in Abdominal Transplant Recipients

• C. Donnell{1}, L. Chargualaf{2}, A. Prom{3}, J. M. Trexler{2}, K. R. Szempruch{2}, {1}UNC Eshelman School of Pharmacy, Chapel Hill, NC, {2}UNC Medical Center, Chapel Hill, NC, {3}Northwestern Medicine, Chicago, IL

Transplant Centers Kidney Acceptance Rates Vary Even After Risk Adjusting for Donor and Kidney Characteristics as Well as Cold Time at Offer

• S. Dey{1}, M. Barah{2}, V. Kilambi{3}, S. Mehrotra{1}, {1}Northwestern University, Evanston, IL, {2}Northwestern University, Northwestern University, IL, {3}RAND Corporation, Arlington, VA

Posoleucel for BKV Infection in Kidney Transplant Patients: Final Results from Randomized, Placebo-Controlled Phase 2 Trial

• A. Chandraker{1}, A. Regmi{2}, R. Gohh{3}, A. Sharma{4}, S. E. Woodle{5}, M. J. Ansari{6}, V. Nair{7}, L. Chen{8}, T. Alhamad{9}, S. Norman{10}, F. Cardarelli{11}, J. Ma{11}, S. Gilmore{11}, S. Vasileiou{11}, D. Wojciechowski{12}, {1}Brigham and Women's Hospital, Boston, MA, {2}Inova Transplant Center, Falls Church, VA, {3}Rhode Island Hospital, Providence, RI, {4}University of Pittsburg Medical Center, Pittsburgh, PA, {5}University of Cincinnati, Cincinnati, OH, {6}Northwestern University, Chicago, IL, {7}Northwell Health, New Hyde Park, NY, {8}UC Davis Transplant Center, Sacramento, CA, {9}Washington University School of Medicine at St. Louis, Saint Louis, MO, {10}University of Michigan, Ann Arbor, MI, {11}AlloVir, Waltham, MA, {12}University of Texas Southwestern Medical Center, Dallas, TX

Hypothermic Oxygenated Machine Perfusion (HMP-O2) in Liver Transplantation: The PilotTM Experience

• G. Panayotova{1}, A. Rana{2}, R. C. Quillin III{3}, K. Lunsford{4}, V. Agopian{5}, D. Markovic{5}, Y. Qin{4}, F. Paterno{4}, A. Amin{4}, G. Lee-Riddle{4}, A. Griesemer{6}, D. Alonso{7}, J. Rocca{8}, D. Borja-Cacho{9}, R. Hernandez-Alejandro{10}, J. Fung{11}, S. Pelletier{12}, S. Shah{13}, J. Guarrera{14}, {1}Surgery, Rutgers NJMS, Newark, NJ, {2}Baylor University, Missouri City, TX, {3}University of Cincinnati College of Medicine, Cincinnati, OH, {4}Rutgers New Jersey Medical School, Newark, NJ, {5}UCLA School of Medicine, LA, CA, {6}Columbia University Medical Center, New York, NY, {7}Intermountain Medical Center, Murray, UT, {8}Montefiore Medical Center, New York, NY, {9}Northwestern University Medical Center, Chicago, IL, {10}University of Rochester Medical Center, Rochester, NY, {11}University of Chicago Medical Center, Chicago, IL, {12}University of Virginia Health System, Charlottesville, VA, {13}University of Cincinnati, Cincinnati, OH, {14}Surgery/ Transplant, Rutgers New Jersey Medical School, Newark, NJ

Impact of Desensitization Therapy with Isatuximab on Circulating HLA-Specific Memory B Cells in Highly Sensitized Patients Waitlisted for Kidney Transplantation

• A. Torija{1}, D. Kervella{1}, L. Donadeu{1}, M. Meneghini{1}, E. Crespo{1}, F. Moreso{1}, J. Cruzado{2}, R. Buchli{3}, F. Vincenti{4}, A. Brar{4}, A. Tambur{5}, M. Stegall{6}, H. Lee{7}, M. Dudek{7}, G. Abbadessa{8}, O. Bestard{1}, {1}Translational Transplant Center, Vall D'Hebron University Hospital, Barcelona, Spain, {2}Bellvitge University Hospital, Barcelona, Spain, {3}Pure Protein, LLC, Oklahoma City, OK, {4}University of California San Francisco, San Francisco, CA, {5}Northwestern University, Chicago, IL, {6}Mayo Clinic, Rochester, MN, {7}Sanofi, Cambridge, MA, {8}Sanofi, Cambrige, MA

Safety and Efficacy of Kidney Transplantation from Donors with HIV to Recipients with HIV: Results of the Multicenter Hope in Action Study

• C. Durand{1}, S. Florman{2}, T. Liang{3}, M. Rana{2}, R. Friedman-Moraco{4}, A. Gilbert{5}, P. Stock{6}, S. Mehta{7}, S. A. Mehta{8}, V. Stosor{9}, M. Pereira{10}, M. Morris{11}, J. Hand{12}, J. Schaenman{13}, S. Aslam{14}, M. Malinis{15}, G. Haidar{16}, C. Small{17}, C. Santos{18}, J. Baddley{19}, E. Blumberg{20}, D. Wojciechowski{21}, N. Elias{22}, S. Apewokin{23}, D. Brown{3}, N. Desai{3}, J. Odim{24}, A. Tobian{3}, A. Massie{8}, D. Segev{8}, {1}Medicine, JHU, BALTIMORE, MD, {2}Sinai, NYC, NY, {3}JHU, Baltimore, MD, {4}Emory, Atlanta, GA, {5}Georgetown, Washington, DC, {6}UCSF, San Francisco, CA, {7}UAB, Birmingham, AL, {8}NYU, NYC, NY, {9}Northwestern, Chicago, IL, {10}Columbia, NYC, NY, {11}Univ of Miami, Miami, FL, {12}Ochsner, New Orleans, LA, {13}UCLA, LA, CA, {14}UCSD, San Diego, CA, {15}Yale, New Haven, CT, {16}UPMC, Pittsburgh, PA, {17}Cornell, NYC, NY, {18}Rush, Chicago, IL, {19}UMD, Baltimore, MD, {20}UPenn, Philadelphia, PA, {21}UTSW, Dallas, TX, {22}MGH, Boston, MA, {23}Univ of Chicago, Chicago, IL, {24}NIH, Bethesda, MD

Alemtuzumab vs. Anti-Thymocyte Globulin in Kidney Transplant Recipients Receiving a Steroid Free Maintenance Regimen

• R. Rikard{1}, L. Chargualaf{1}, A. Prom{2}, C. Coulter{1}, E. Weimer{1}, J. Schmitz{1}, E. Kotzen{1}, K. Szempruch{1}, {1}UNC Health, Chapel Hill, NC, {2}Northwestern Memorial Hospital, Chicago, IL

Association of HLA Eplet Mismatch with Positive Gene Expression and dd-cfDNA Biomarkers in Kidney Transplant Recipients 

• A. Ahmed{1}, B. Kinsella{2}, C. Rebello{2}, K. Guo{2}, S. Park{2}, T. Whisenant{3}, J. Friedewald{2}, {1}Chicago Medical School at Rosalind Franklin University, Chicago, IL, {2}Northwestern University, Chicago, IL, {3}UCSD, San Diego, CA

How Do IRB Members and Ethicists Assess the Risk of Zoonotic Disease Transmission in Xenotransplant Pig Kidney Clinical Trials?

• M. M. Matthews{1}, E. J. Gordon{2}, M. K. Gusmano{3}, J. Gacki-Smith{4}, K. Traboulsi{3}, J. J. Uriarte{4}, D. Manning{4}, J. Leventhal{5}, K. J. Maschke{6}, {1}The Hastings Center, Brooklyn, NY, {2}Vanderbilt University, Nashville, TN, {3}Lehigh University, Bethelham, PA, {4}Northwestern Univeristy, Chicago, IL, {5}Northwestern Medicine, Chicago, IL, {6}The Hastings Center, Garrison, NY

Modeling of Non-Alcoholic Steatohepatitis Ex-Vivo Using Hepatocyte-Like Cells Differentiated from Human Induced Pluripotent Stem Cells

• E. Minocha{1}, A. Kumar Gupta{1}, A. Benintende{2}, J. Purdy{1}, R. Green{2}, J. A. Wertheim{1}, {1}University of Arizona College of Medicine - Tucson, Tucson, AZ, {2}Northwestern University Feinberg School of Medicine, Chicago, IL

Potential Living Kidney Donors’ Concerns About Opting Out and Preferences for an Alibi: Results from a Multicenter Study

• K. Yu{1}, J. Gannon{2}, S. Li{2}, D. Dobosz{2}, K. Kennedy{3}, D. Gray{4}, A. Mussell{4}, P. Reese{4}, E. Gordon{3}, S. Kulkarni{2}, C. Thiessen{5}, {1}Columbia University, New York, NY, {2}Yale U, New Haven, CT, {3}Northwestern U, Chicago, IL, {4}U Pennsylvania, Philadelphia, PA, {5}UW Madison, Madison, WI

Who Should Participate in First-In-Human Pig Xenotransplant Clinical Trials?

• M. K. Gusmano{1}, K. Maschke{2}, J. Gacki-Smith{3}, M. Matthews{2}, K. Traboulsi{4}, D. Manning{3}, J. Uriarte{3}, J. Leventhal{5}, E. J. Gordon{6}, {1}College of Health, Lehigh University, Bethlehem, PA, {2}The Hastings Center, Garrison, NY, {3}Northwestern University, Chicago, IL, {4}Lehigh University, Bethlehem, PA, {5}Northwestern Medicine, Chicago, IL, {6}Surgery, Northwestern University Feinberg School of Medicine, Oak Park, IL

Clinical Application and Outcomes with Use of the Heart Organ Care System

•  J. Stehlik{1}, C. Milano{2}, S. Pinney{3}, C. Patel{4}, D. D'Alessandro{5}, R. P. Davis{6}, C. Maulion{6}, D. Goldstein{7}, U. Jorde{7}, J. Pal{8}, M. Daneshmand{9}, F. Esmailian{10}, J. A. Kobashigawa{11}, S. Pham{12}, P. Patel{12}, K. Takeda{13}, N. Uriel{13}, A. S. Shah{14}, M. Kai{15}, G. Couper{16}, A. Vest{16}, B. Sun{17}, L. Lozonschi{18}, M. Ono{19}, L. Klein{20}, D. T. Pham{21}, D. Joyce{22}, H. Mallidi{23}, M. R. Mehra{23}, M. Farr{24}, {1}University Of Utah School Of Medicine, Salt Lake City, UT, {2}Duke University, Durham, NC, {3}University of Chicago, Chicago, IL, {4}Duke University Med Ctr, Durham, NC, {5}Massachusetts General Hospital, Boston, MA, {6}Yale New Haven Hospital, New Haven, CT, {7}Montefiore Medical Center, Bronx, NY, {8}University of Washington Medical Center, Seattle, WA, {9}Emory University Hospital, Atlanta, GA, {10}Cedars-Sinai Medical Center, Los Angeles, CA, {11}Cedars-Sinai Smidt Heart Institute, Los Angeles, CA, {12}Mayo Clinic Florida, Jacksonville, FL, {13}New York Presbyterian Hospital, New York, NY, {14}Vanderbilt University Medical Center, Mount Juliet, TN, {15}Westchester Medical Center, Valhalla, NY, {16}Tufts Medical Center, Boston, MA, {17}Minneapolis Heart Institute, Minneapolis, MN, {18}Tampa General Hospital, Tampa, FL, {19}Methodist Specialty and Transplant Hospital, San Antonio, TX, {20}University of California San Francisco Medical Center, San Francisco, CA, {21}Northwestern Memorial Hospital, Chicago, IL, {22}Froedtert Memorial Lutheran Hospital, Milwaukee, WI, {23}Brigham and Womens Hospital, Boston, MA, {24}University of Texas Southwestern, Dallas, TX

Infections After Kidney Transplantation from Donors with Hiv to Recipients with Hiv: Results from the Multicenter Hope in Action Study

• W. Werbel{1}, T. Liang{2}, M. Rana{3}, S. Florman{3}, R. Friedman-Moraco{4}, A. Gilbert{5}, P. Stock{6}, S. Mehta{7}, H. Neumann{7}, S. Mehta{8}, V. Stosor{9}, M. Pereira{10}, M. Morris{11}, J. Hand{12}, J. Schaenman{13}, S. Aslam{14}, M. Malinis{15}, G. Haidar{16}, C. Small{17}, C. Santos{18}, J. Castillo-Lungo{19}, O. Adebiyi{20}, J. Baddley{21}, K. Ranganna{22}, E. Blumberg{23}, D. Wojciechowski{24}, J. Odim{25}, A. Massie{7}, D. Segev{7}, C. Durand{2}, {1}Johns Hopkins, Baltimore, MD, {2}J Hopkins, Baltimore, MD, {3}Mt. Sinai, NY, NY, {4}Emory, ATL, GA, {5}Georgetown, DC, DC, {6}UCSF, San Francisco, CA, {7}NYU, NY, NY, {8}UAB, Birmingham, AL, {9}Northwestern, CHI, IL, {10}Columbia, NYC, NY, {11}UMiami, Miami, FL, {12}Ochsner, New Orleans, LA, {13}UCLA, Los Angeles, CA, {14}UCSD, San Diego, CA, {15}Yale, New Haven, CT, {16}UPMC, Pittsburgh, PA, {17}Cornell, NY, NY, {18}Rush, CHI, IL, {19}Methodist, Dallas, TX, {20}Indiana U, Indianapolis, IN, {21}UMaryland, Baltimore, MD, {22}Drexel, PHL, PA, {23}UPenn, PHL, PA, {24}UTSW, Dallas, TX, {25}NIH, Bethesda, MD

Multiscale Genetic Architecture of Donor-Recipient Differences Reveals Intronic Lims1 Locus Mismatches Associated with Long-Term Renal Transplant Survival

• M. Menon{1}, Z. Zhang{2}, K. Banu{3}, I. Gibson{4}, R. Colvin{5}, Z. Yi{2}, W. Zhang{2}, L. Gallon{6}, P. O'Connell{7}, J. Pober{3}, P. Heeger{8}, M. Menon{3}, {1}Yale School of Medicine, New Haven, CT, {2}Icahn School of Medicine at Mount Sinai, New York City, NY, {3}Yale University School of Medicine, New Haven, CT, {4}Max Rady College of Medicine, Edmundston, MB, Canada, {5}Massachusetts General Hospital, Boston, MA, {6}Northwestern University NMFF, Chicago, IL, {7}University of Sydney, NSW, Australia, {8}Cedars-Sinai Medical Center, West Hollywood, CA

Defining the Minimal Clinically Important Differences in Physical Frailty Using the Liver Frailty Index in Patients with Cirrhosis Awaiting Liver Transplantation

• M. Wang{1}, A. Shui{1}, J. Ruck{2}, C. Huang{1}, E. Verna{3}, E. King{2}, D. P. Ladner{4}, D. Ganger{5}, M. Kappus{6}, R. S. Rahimi{7}, M. Volk{8}, A. Tevar{9}, A. Duarte{10}, J. C. Lai{1}, {1}University of California San Francisco, San Francisco, CA, {2}Johns Hopkins Hospital, Baltimore, MD, {3}Columbia University, New York, NY, {4}Northwestern Medicine, Chicago, IL, {5}Northwestern University, Chicago, IL, {6}Duke University, Raleigh, NC, {7}Baylor Scott and White Health, Dallas, TX, {8}Loma Linda University, Loma Linda, CA, {9}University of Pittsburgh Medical Center, Pittsburgh, PA, {10}Northwestern University, Chicago, IL

Indirect Evidence for Circulating Factors in Focal Segmental Glomerulosclerosis Via Molecular Analysis of Podocyte Injury in Kidney Organoids 

• A. K. Gupta{1}, E. Minocha{1}, A. Abu Maziad{1}, J. A. Wertheim{1}, L. G. Gallon{2}, {1}University of Arizona College of Medicine - Tucson, Tucson, AZ, {2}Northwestern University Feinberg School of Medicine, Chicago, IL

Longitudinal Evaluation of Immune Single Cell Transcriptome of Living Donor Kidney Transplant Recipients Tolerized with Allogeneic Stem Cell Therapy

• H. Zubair{1}, T. Rousselle{1}, A. Shetty{1}, S. Azim{1}, C. Suire{2}, J. R. Leventhal{3}, S. Ildstad{2}, V. Mas{1}, {1}Surgical Sciences, University of Maryland, Baltimore, MD, {2}Talaris Therapeutics, Louisville, KY, {3}Surgery, Northwestern Medicine, Chicago, IL

Predicting Evaluation Completion and Donation by Relationship Type: Identifying Opportunities for More Donors

• J. Daw{1}, A. Meinders{2}, J. D. Peipert{3}, E. Graviss{2}, D. T. Nguyen{2}, F. Weng{4}, A. Waterman{2}, {1}Pennsylvania State University, University Park, PA, {2}Houston Methodist Hospital, Houston, TX, {3}Northwestern University, Chicago, IL, {4}Saint Barnabas Medical Center, Livingston, NJ

Recovery of Physical Function (PF) After Kidney (KT) versus Liver (LT) Transplantation

• I. Mucsi{1}, N. Jain{2}, Y. Chien{2}, N. Edwards{2}, D. Lodge{2}, T. Patel{2}, A. Samudio{2}, D. Howell{3}, M. Li{4}, J. Peipert{5}, S. J. Bartlett{6}, N. Selzner{2}, {1}Toronto General Hospital, Toronto, ON, Canada, {2}University Health Network, Toronto, ON, Canada, {3}University of Toronto, Toronto, ON, Canada, {4}Princess Margaret Cancer Center, Toronto, ON, Canada, {5}Northwestern University, Chicago, IL, {6}McGill University, Montreal, QC, Canada

Social Participation in Kidney Transplant Recipients (KT) Compared to Patients on Hemodialysis (HD)

• I. Mucsi{1}, M. Siddiqui{2}, J. Wang{2}, J. Kalaher{2}, V. Baltazar{2}, L. Kerr{2}, A. Sampathu{2}, J. Peipert{3}, S. J. Bartlett{4}, M. Li{5}, D. Howell{6}, M. Novak{6}, {1}Toronto General Hospital, Toronto, ON, Canada, {2}University Health Network, Toronto, ON, Canada, {3}Northwestern University, Chicago, IL, {4}McGill University, Montreal, QC, Canada, {5}Princess Margaret Cancer Center, Toronto, ON, Canada, {6}University of Toronto, Toronto, ON, Canada

Understanding Humanistic Motivations of Potential Living Donors Who Are Friends and Acquaintances Compared to Family Members

• A. M. Meinders{1}, J. Daw{2}, J. D. Peipert{3}, E. A. Graviss{1}, D. T. Nguyen{1}, F. Weng{4}, A. Waterman{1}, {1}Houston Methodist Hospital, Houston, TX, {2}The Pennsylvania State University, University Park, PA, {3}Northwestern University, Chicago, IL, {4}Saint Barnabas Medical Center, Livingston, NJ

What Information Do Kidney Transplant Candidates Need to Make Informed Treatment Decisions About Participating in a First-In-Human Pig Xenotransplant Clinical Trial? 

• E. J. Gordon{1}, K. Maschke{2}, J. Gacki-Smith{3}, M. Matthews{2}, K. Traboulsi{4}, D. Manning{3}, J. Uriarte{3}, J. Leventhal{5}, M. Gusmano{4}, {1}Vanderbilt University Medical Center, Nashville, TN, {2}The Hastings Center, Garrison, NY, {3}Northwestern University Feinberg School of Medicine, Chicago, IL, {4}Lehigh University, Bethlehem, PA, {5}Northwestern Medicine, Chicago, IL

Would Kidney Transplant Candidates Participate in a First-In-Human Pig Xenotransplant Clinical Trial?

• E. J. Gordon{1}, M. Gusmano{2}, J. Gacki-Smith{3}, M. Matthews{4}, K. Traboulsi{2}, D. Manning{3}, J. Uriarte{3}, J. Leventhal{5}, K. Maschke{4}, {1}Vanderbilt University Medical Center, Nashville, TN, {2}Lehigh University, Bethlehem, PA, {3}Northwestern University Feinberg School of Medicine, Chicago, IL, {4}The Hastings Center, Garrison, NY, {5}Northwestern Medicine, Chicago, IL

Polyclonal Treg Therapy for Renal Allograft Inflammation: Results of CTOT-21, A Randomized Controlled Clinical Trial

• S. Chandran{1}, Q. Tang{1}, J. C. Leung{1}, Z. Laszik{1}, B. Armstrong{2}, M. Morsheimer{3}, E. Farkash{4}, R. B. Mannon{5}, S. Davis{6}, J. Friedewald{7}, F. Vincenti{1}, {1}UCSF, San Francisco, CA, {2}Rho, Durham, NC, {3}DAIT, NIAID, Bethesda, MD, {4}U of Michigan, Ann Arbor, MI, {5}U of Nebraska, Omaha, NE, {6}U of Colorado, Denver, CO, {7}Northwestern U, Chicago, IL

Maintenance of Lung Graft Tolerance is Dependent on Continuous Recruitment of Foxp3+ Cells to Allografts

• Y. Bai{1}, W. Li{1}, Y. Terada{1}, H. M. Shepherd{1}, J. M. Gauthier{1}, Y. Yokoyama{1}, A. Bery{1}, A. Alessandrini{2}, P. T. Sage{3}, A. Bharat{4}, R. G. Nava{1}, A. S. Krupnick{5}, A. E. Gelman{1}, K. J. Lavine{1}, D. Kreisel{1}, {1}Washington University in St. Louis, St. Louis, MO, {2}Massachusetts General Hospital, Boston, MA, {3}Brigham and Women's Hospital, Boston, MA, {4}Northwestern University, Chicago, IL, {5}University of Maryland, Baltimore, MD

Wait Time Advantage for Transplant Candidates with HIV Who Accept Kidneys from Donors with HIV

• J. D. Motter{1}, S. Hussain{2}, S. Florman{3}, M. Rana{3}, R. Friedman-Moraco{4}, A. Gilbert{5}, P. Stock{6}, S. Mehta{7}, S. A. Mehta{1}, V. Stosor{8}, N. Elias{9}, M. Pereira{10}, G. Haidar{11}, M. Malinis{12}, M. Morris{13}, J. Hand{14}, S. Aslam{15}, J. Schaenman{16}, J. Baddley{17}, C. Small{18}, D. Wojciechowski{19}, E. F. Hollinger{20}, E. Blumberg{21}, J. Odim{22}, S. Apewokin{23}, E. Giorgakis{24}, A. Tobian{2}, D. Segev{1}, A. B. Massie{1}, C. M. Durand{2}, {1}NYU, New York, NY, {2}JHU, Baltimore, MD, {3}Mt Sinai, New York, NY, {4}Emory, Atlanta, GA, {5}Medstar Georgetown, Washington, DC, {6}UCSF, San Francisco, CA, {7}UAB, Birmingham, AL, {8}Northwestern, Chicago, IL, {9}MGH, Milton, MA, {10}Columbia, New York, NY, {11}UPMC, Pittsburgh, PA, {12}Yale, New Haven, CT, {13}University of Miami, Miami, FL, {14}Ochsner, New Orleans, LA, {15}UCSD, San Diego, CA, {16}UCLA, Los Angeles, CA, {17}UMD, Baltimore, MD, {18}Weill Cornell, New York, NY, {19}UT SW, Dallas, TX, {20}Rush, Chicago, IL, {21}UPenn, Philadelphia, PA, {22}NIAID, Bethesda, MD, {23}University of Cincinnati, Cincinnati, OH, {24}UAMS, Little Rock, AR

Treg Modulation with CD28 and IL-6 Receptor Antagonists in Kidney Transplant Recipients: Results of CTOT-24, a Prospective Clinical Trial

• S. Chandran{1}, Q. Tang{1}, J. Leung{1}, B. Armstrong{2}, J. Friedewald{3}, A. Kirk{4}, M. Morsheimer{5}, F. Vincenti{1}, {1}UCSF, San Francisco, CA, {2}Rho, Durham, NC, {3}Northwestern U, Chicago, IL, {4}Duke U, Durham, NC, {5}NIAID, Bethesda, MD