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All Clinical Trials

Northwestern Scleroderma Program Registry

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NU 05H6: Acute Leukemias and Map Kinase

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NCI 02X3: SPORE in Pancreatic Cancer Tissue Core

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HLA-Identical Sibling Renal Transplant Tolerance With Donor Hematopoietic Stem Cells and Campath-1H

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Chicago Lupus Database

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Characteristics of the Stretch Reflex Response in Various Joints

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DERMATOLOGY TISSUE ACQUISITION AND REPOSITORY

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NUGene: Gene-Disease Associations and Treatment Outcomes

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Eye Donor Program

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Genetics of BRCA2-related Prostate Cancer

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Mediators of Atherosclerosis in South Asians Living in America

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NU 00X3: Pathology Core Facility

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RTOG 0724 - A Phase III Randomized Study of Concurrent Chemotherapy and Pelvic Radiation Therapy with or without Adjuvant Chemotherapy in High-Risk Patients with Early-Stage Cervical Carcinoma Following Radical Hysterecotmy

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Asymmetric Neurodegeneration and Language in Primary Progressive Aphasia

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Chemokine mechanisms in chronic pelvic pain

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NU 99G8: Northwestern Ovarian Cancer Early Detection and Prevention Program: A Specimen and Data Study

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Alzheimer's Disease Research Center

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Neural Mechanisms in Sensory Reception and Processing in the Healthy Adult (VA RR&D Grant # B3302K)

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NCI 01X1: Breast Cancer Program: Tissue and Specimen Collection Facility

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Peripheral Neuropathy Research Registry (PNRR)

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NU 04H7: Molecular Mechanisms of Disease Progression in Myeloid Malignancy

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A Family Study of Pragmatic Language

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Northwestern University The Department of Psychiatry and Behavioral Sciences, Clinical Research Program (NU CRP) Recruitment Pipeline

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A PHASE 3 SINGLE CENTER STUDY OF ISLET TRANSPLANTATION IN NON-UREMIC DIABETIC PATIENTS

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A Randomized Trial to Prevent Congenital Cytomegalovirus Infection (CMV)

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A Registry of Interstitial Lung Disease Patients

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NCI 12H13: Molecular Mechanisms of Relapse After Therapy Discontinuation in Chronic Myeloid Leukemia

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CENTER FOR BEHAVIORAL INTERVENTION TECHNOLOGIES (CBITs) RESEARCH SUBJECT RECRUITMENT REGISTRY

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Targeting Siglecs in Disease

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NUDB 13C03: Northwestern Brain Tumor Institute Research Database

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Movement Disorders Biorepository

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A Long-Term Non-Interventional Registry to Assess Safety and Effectiveness of HUMIRA® (Adalimumab) in Patients with Moderately to Severely Active Ulcerative Colitis (LEGACY)

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Healthy Control Esophageal Registry and Biorepository

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Neural Systems for the Dynamic Use of Memory

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Noninvasive Manipulation of Hippocampal-Cortical Brain Networks and Memory

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Development of a Kidney Cancer Patient Outcomes Database

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Synovial Macrophage Transcriptional Signatures for Predicting Therapeutic Efficacy

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HOme-based moNitORed exercise for PAD

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Ex vivo interactions between high-density-like nanoparticles and human blood

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NCI 15H01: Triad1 Regulates Myelopoiesis and Functions as a Leukemia Suppressor

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Low InTensity Exercise intervention in PAD: The LITE Trial.

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A Randomized Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation with a Short Cervix (PROSPECT)

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Telmisartan Plus Exercise to Improve Functioning in PAD

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Chronic Kidney Disease Research Biorepository

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Improving Outpatient Safety of Older Adults through Electronic Patient Portals

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High Resolution and Functional MRI Assessment of Intracranial Atherosclerotic Plaque

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LIFT: Lupus Intervention for Fatigue Trial

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The ENabling Reduction of low-Grade Inflammation in SEniors) Pilot Study

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A large-scale multicenter phase II study evaluating the protective effect of a tissue selective estrogen complex (TSEC) in women with newly diagnosed ductal carcinoma in situ.

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NU 15N01: Head and Neck Tissue Bank

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NU 15N02: Northwestern Head and Neck Cancer Registry

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Motivational Interviewing and Physical Activity in Parkinson’s Disease

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Semen quality in males with inflammatory bowel disease: Influence of medication for IBD

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Epidermolysis Bullosa Clinical Characterization and Outcomes Database

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North American Registry for Care and Research in Multiple Sclerosis (NARCRMS) Study

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LiveWell: A Mobile Intervention for Bipolar Disorder

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Efficacy of Couples-Based HIV Prevention in Vulnerable Young Men

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Cocoa to Improve Walking Performance in Peripheral Artery Disease: The COCOA-PAD Study

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MAST CELLS IN MALE CHRONIC PELVIC PAIN AND LOWER URINARY TRACT DYSFUNCTION

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A Phase 2, single arm, multi-center, open label trial Combining Optune with concurrent Bevacizumab in the setting of Recurrent or Progressive Meningioma

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NU 16B06: Investigation of Blood-Based Prognostic Biomarkers in Patients with Advanced Breast Cancer for Molecular Mechanisms Underlying Circulating Tumor Cell Clusters

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Evaluating the Circadian Response to Light in Delayed Sleep-Wake Phase Disorder

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A wearable myoelectric-computer interface to reduce muscle co-activation in acute and chronic stroke

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Alzheimer’s Disease Neuroimaging Initiative 3

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NUDB 16Z01: The OncoSET Program Database and Biobank - Combining Clinical Outcomes with Next Generation Sequencing and other Advanced Molecular Testing for Genetic Aberrations in Patients with Advanced Solid Malignancies

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MISCEND

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Improve PAD PERformance with METformin: The PERMET Trial

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Investigating Serum Concentrations of Mood Stabilizing Medications in Pregnancy and Postpartum

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Enroll-HD: A Prospective Registry Study in a Global Huntington’s Disease Cohort

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ELUCDITATING THE MOLECULAR MECHANISMS UNDERLYING CYP2D6 INDUCTION DURING PREGNANCY

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Neuromodulation and Neurorehabilitation for Treatment of Functional Deficits after mTBI plus PTSD

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INtervention Study In OverweiGHT Patients with COPD (INSIGHT COPD)

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The Role of Circadian Dysfunction in Hepatic Encephalopathy in Patients with Cirrhosis

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Bimanual balanced reaching with visual biofeedback

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Clinical Research Consortium for the Study of Cerebellar Ataxia (CRC-SCA) to Study Natural History and Genetic Modifiers in Spinocerebellar Ataxia (SCA)

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Partner 3 AVIV Registry

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Long-Term Nicotine Treatment of Mild Cognitive Impairment

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A Randomized Trial of Pessary in Singleton Pregnancies with a Short Cervix (TOPS)

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Physical activity and DNA methylation among women with high breast density

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Melanoma and Skin Cancer Tissue Repository

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Quantitative Detection of Coronary Microvascular Dysfunction in Long COVID Patients Using a Comprehensive, Rapid, Free-Breathing Cardiovascular MRI

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D-Cycloserine for the Treatment of Chronic, Refractory Low Back Pain

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Transformative Research In Diabetic Nephropathy (TRIDENT) (SP0043185)

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The Role of Positron Emission Tomography and Magnetic Resonance Imaging (without Fluorodeoxyglucose or Gadolinium) in Yttrium-90 Radioembolization Treatment Planning for Patients with Liver Malignancies

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Brain Stimulation and Memory Study

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Genetic causes and pathogenic mechanisms of adult epilepsies

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Alterations of Sleep and Circadian Timing in Aging

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NIH All of Us Research Program Precision Medicine Initiative® Precision Medicine Initiative Cohort Program Healthcare Provider Organization Enrollment Centers

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Clinical Database of Prostate Cancer at Northwestern University

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Bilateral Priming plus Task Specific Training for Severe Upper Limb Hemiparesis

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Strengthening Circadian Signals to Enhance Cardiometabolic Functions

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APOLLO

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A Natural History Observation and Registry Study of Macular Telangiectasia Type 2: The MACTEL Study

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(xIRB) The CHRONICLE Study: A Longitudinal Prospective Observational Study of the Characteristics, Treatment Patterns and Health Outcomes of Individuals with Severe Asthma in the United States

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Clinical Trial Readiness for SCA1 and SCA3

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CHRONIC VENOUS THROMBOSIS: RELIEF WITH ADJUNCTIVE CATHETER-DIRECTED THERAPY

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Mitochondrial Dysfunction and Disability in Peripheral Artery Disease

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Vasculitis Clinical Research Consortium (VCRC) Genetic Repository One Time DNA Protocol

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Evaluation of Renal Microvascular Perfusion by Contrast Enhanced Ultrasound

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Longitudinal Early-onset Alzheimer’s Disease Study (LEADS)

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Effects of device-assisted practice of activities of daily living in a close-to-normal pattern on upper extremity motor recovery in individuals with moderate to severe stroke

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Randomized Controlled Trial of a Mindfulness-based Intervention in a Federally Qualified Center (FQHC)

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Pathogenic Wnt-beta catenin target genes in macrophages and fibrosis

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A Randomized, Multicenter, Double-Blind, Parallel, Active-Control Study of the Effects of Sparsentan, A Dual Endothelin Receptor and Angiotensin Receptor Blocker, on Renal Outcomes in Patients with Primary Focal Segmental Glomerulosclerosis

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A pragmatic trial of two strategies for implementing an effective eHealth HIV prevention program (Keep It Up! 3.0)

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Gut Microbial remodeling with Resistant Maltodextrin for motor and non-motor symptoms in Parkinson's disease: safety and tolerability study.

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Project 1, Adaptations of the brain in chronic pain with opioid exposure

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Wearable sensors and video recording for children (birth to 24 months) to monitor motor development

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The Collaborative, National Quality and Efficacy Registry (CONQUER)

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Brain pathophysiology of osteoarthritis pain

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AF STOP: AF Substrate as an Outcome and Predictor of successful AF ablation

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Real-time Wideband Cardiac MRI for Patients with a Cardiac Implantable Electronic Device

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PK and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants

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The effect of inflammatory bowel disease flares on serum prostate specific antigen

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CalorieHarmony for Obesity

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Randomized trial of Retropubic versus Single-incision Mid-Urethral Sling (Altis™) for Concomitant Management of Stress urinary incontinence during Native Tissue Vaginal Repair

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Impaired sensorimotor integration for prosodic speech production in Ataxic Dysarthria

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BP40283 -Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Assess The Effects of RO6889450 in Patients with Schizophrenia or Schizoaffective Disorder and Negative Symptoms

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CLASP IID/IIF

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NU 18B05: A Phase II Study of the Determinants of Transdermal Drug Delivery to the Normal and the Radiated Breast

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The Impact of Low Flow Nocturnal Oxygen Therapy on Hospital Admissions and Mortality in Patients with Heart Failure and Central Sleep Apnea.

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Characterization of the microbiome in cutaneous T cell lymphoma

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Northwestern TIPS Research Study

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A Phase 3, Multicenter, Randomized, Placebo- and Active Comparator-Controlled Study Evaluating the Efficacy, Safety, and Pharmacokinetics of Subcutaneously Administered Guselkumab for the Treatment of Chronic Plaque Psoriasis in Pediatric Subjects ((≥6 To <18 Years of Age)

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A Longitudinal Observational Study of Patients Undergoing Therapy for Immune-Mediated Inflammatory Skin Conditions

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(xIRB) NRG-BN005 A Phase II Randomized Trial of Proton vs. Photon Therapy (IMRT) for Cognitive Preservation in Patients with IDH Mutant, Low to Intermediate Grade Gliomas.

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A Master Protocol To Evaluate Biomarker-Driven Therapies And Immunotherapies In Previously-Treated Non-Small Cell Lung Cancer (Lung-MAP Screening Study)

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Modulating stimuli intensity to improve clinical outcomes in aphasia treatment

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A Prospective, Multicenter Study of Artemis a Minimally Invasive Neuro Evacuation Device, in the Removal of Intracerebral Hemorrhage (MIND)

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NU MTBC 18M02: International Melanoma Tissue Bank Consortium Site at Northwestern University

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Alliance A041703: A Phase II Study of Inotuzumab Ozogamicin Followed by Blinatumomab for Ph-negative CD22-positive B-lineage Acute Lymphoblastic Leukemia in Newly Diagnosed Older Adults or Adults with Relapsed or Refractory Disease

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A Phase 3, Multinational, Double-Blind, Randomized, Placebo-Controlled Study of MGL-3196 (resmetirom) in Patients With Non-Alcoholic Steatohepatitis (NASH) and Fibrosis to Resolve NASH and Reduce Progression to Cirrhosis and/or Hepatic Decompensation

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A041702: A Randomized Phase III Study of Ibrutinib Plus Obinutuzumab Versus Ibrutinib Plus Venetoclax and Obinutuzumab in Untreated Older Patients (= 70 Years of Age) with Chronic Lymphocytic Leukemia (CLL)

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Yttrium-90 Radiation Lobectomy: Dose Optimization and Prediction of FLR Hypertrophy to Enable Resection of Hepatic Malignancies

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Natural history study of ALS and other motor neuron disorders

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Parkinson’s Foundation Genetic Research Initiative

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GSO 18-01 (REDUCE PAS)

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BTCRC HN17-111: Phase II trial of androgen deprivation therapy (ADT) and pembrolizumab for advanced stage androgen receptor-positive salivary gland carcinoma

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PD-inhibitor (Nivolumab) and Ipilimumab followed by nivolumab vs. VEGF TKI cabozantinib with nivolumab in metastatic untreated REnal Cell CancEr [PDIGREE]

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Parkinson's Disease: Intervening Early Concerning Employment (PIECE) Aims 2 and 3

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(xIRB) NCI CIRB NRG GY019: A Randomized Phase III, Two-Arm Trial of Paclitaxel/Carboplatin/Maintenance Letrozole Versus Letrozole Monotherapy in Patients with Stage II-IV, Primary Low-Grade Serous Carcinoma of the Ovary or Peritoneum

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(xIRB) NCI CIRB: Alliance A071701: Genomically-Guided Treatment Trial in Brain Metastases

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MultiStem® Administration for Stroke Treatment and Enhanced Recovery Study (MASTERS-2) (Protocol #: B01-04)

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A Phase 1 Single- and Multiple-Ascending-Dose Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB094 Administered Intrathecally to Adults With Parkinson’s Disease (Protocol# 254PD101)

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Pathogenesis of Heart Failure with Preserved Ejection Fraction in Chronic Kidney Disease

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(xIRB) Social Processing in Remitted Adolescent Depression

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(xIRB) NCI CIRB ECOG-ACRIN 2182: A Randomized Phase II Study of De-Intensified ChemoRadiation for EarlyStage Anal Squamous Cell Carcinoma (DECREASE)

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DRUG KO-MEN-001: A Phase 1/2 First in Human Study of the Menin-MLL(KMT2A) Inhibitor KO-539 in Patients with Relapsed or Refractory Acute Myeloid Leukemia

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RV Ischemia & Fibrosis in CTEPH

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NU 19H08: Signal Transduction of Type I Interferons in Malignant Cells

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Randomized controlled trial assessing transperineal prostate biopsy to reduce infection complications

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xIRB ALLFTD: ARTFL-LEFFTDS LONGITUDINAL FRONTOTEMPORAL LOBAR DEGENERATION

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Study in Parkinson Disease of Exercise Phase 3 Clinical Trial: SPARX3

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XIRB A master protocol for randomized, placebo-controlled, Phase 2 clinical trials of multiple interventions for the treatment of chronic pain

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TAMBE Pivotal AAA 17-01

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REPAIR-MR

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TeleHD: Feasibility, validity, and value of telemedicine for motor and non-motor assessments in patients with Huntington’s Disease (HD)

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A Multicenter, Adaptive, Randomized Blinded Controlled Trial of the Safety and Efficacy of Investigational Therapeutics for the Treatment of COVID-19 in Hospitalized Adults

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A PHASE II STUDY TO EVALUATE THE SAFETY AND EFFICACY OF OQL011 ON VEGFR INHIBITOR-ASSOCIATED HAND-FOOT SKIN REACTION IN CANCER PATIENTS

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Oxidative Markers and Efficacy in ALS/MND Phenotypes Treated with Edaravone (Loma Linda)

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Angiotensin II for Distributive Shock

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TOPAZ TRIAL OF PARKINSONS AND ZOLEDRONIC ACID A Randomized Placebo-controlled Trial of Zoledronic Acid for Prevention

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CPIRA-2

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Sensory-specific peripheral stimulation for tremor management

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Cure Glomerulonephropathy

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A Phase 1/2a Open-Label Ascending Dose Study to Evaluate the Safety and Effects of LY3884961 in Patients with Parkinson’s Disease with at Least One GBA1 Mutation (PROPEL, Protocol #: J3Z-MC-OJAA previously called PRV-PD101)

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The role of the cortex and brainstem in motor preparation for proximal and distal upper extremity movements

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NU COVID-19 MSK20H04: Examining COVID19 Course and Outcomes in Patients Previously Diagnosed with Chronic Lymphocytic Leukemia (CLL)

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NU FC19L02: Phase II randomized trial of carboplatin + pemetrexed + bevacizumab, with or without atezolizumab in stage IV non-squamous NSCLC patients who harbor a sensitizing EGFR mutation or have never smoked

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Platform Trial for the Treatment of Amyotrophic Lateral Sclerosis (ALS): A perpetual multi-center, multi-regimen clinical trial evaluating the safety and efficacy of investigational products for the treatment of ALS.

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Cardio-TTRansform (ION-682884-CS2)

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NP-SLE

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The Parkinson’s Progression Markers Initiative (PPMI) 2.0 Clinical - Establishing a Deeply Phenotyped PD Cohort

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Screening for Coronavirus Antibodies in Neighborhoods (SCAN)

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Immune checkpoint inhibitor-associated acute kidney injury

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COVID-19 and the impact on the Immune System

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Amplify Gait to Improve Locomotor Engagement in Spinal Cord Injury (AGILE SCI) Trial

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AHEAD 3-45 Study

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Prospective evaluation of an applied ATTR-CM Machine Learning model to a health system electronic health record (EHR)

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A Sequenced Strategy for Improving Outcomes in People with Knee Osteoarthritis Pain (SKOAP)

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African-American Social Support Effectiveness Treatment-Partners alleviating Perinatal Depression (ASSET-PPD)

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A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of AL001 in Individuals at Risk for or With Frontotemporal Dementia Due to Heterozygous Mutations in the Progranulin Gene

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COVID Prevention Trials Registry

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Phase 1/2 trial of blood-brain barrier opening with the SonoCloud-9 implantable ultrasound device and treatment with albumin-bound paclitaxel in patients with recurrent glioblastoma

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Human-like Robot Controllers for Enhanced Motor Learning

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NRG HN006: Randomized Phase II/III Trial of Sentinel Lymph Node Biopsy Versus Elective Neck Dissection for Early-Stage Oral Cavity Cancer

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COVID-19 TestUS an initiative of RADx AcceleRATeD study (Rapid Assessment of Technology for SARS-CoV-2 Detection)

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Prospective Molecular Profiling To Guide Therapeutic Decision-making in Patients with Advanced Hepatocellular Cancer (HCC): An Insight to Next Generation Sequencing-Matched Systemic Therapy in Liver Cancer (PROTOLIGHT STUDY)

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Impact of immunotherapy-related skin diseases on quality of life

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R1: Telehealth Pain Self-Management for Employed Adults (E-TIPS)

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DRUG CCTL019B2003I: Managed Access Program (MAP) Cohort Treatment Plan CCTL019B2003I to provide access for patients with out of specification leukapheresis product and/or out of specification manufactured tisagenlecleucel (CTL019; Kymriah®).

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Evaluating the EVO treatment optimized for resource constraints: Elements Vital to treat Obesity

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xIRB Consortium of Early Arthritis Cohorts USA (CATCH-US) -- A prospective cohort study of adults with new onset inflammatory arthritis symptoms to understand predictors of optimal outcomes

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NU MSK19H03 : Combination Therapy with Entinostat and Pembrolizumab in Relapsed and Refractory Lymphomas

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(xIRB) NCI CIRB SWOG 1823: A Prospective Observational Cohort Study to Assess mRNA 371 for Outcome Prediction in Patients with Newly Diagnosed Germ Cell Tumors

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Tape Strip Analysis in Dermatologic Diseases

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(xIRB) NCI CIRB ETCTN 10276: A Phase I/II Study of M3814 and Avelumab in Combination with Hypofractionated Radiation in Patients with Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies

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Alliance A021806: A Phase III Trial of Perioperative Versus Adjuvant Chemotherapy for Resectable Pancreatic Cancer

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OPT2MOVE

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Use of Glenohumeral Injections for Management of Shoulder Pain in Individuals with ALS

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A Prospective and Retrospective Clinical, Histological and Molecular Analysis of the Spectrum of Cutaneous Presentations in Adult Patients Admitted to the Hospital

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TRISCEND II

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A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel Arm, Multicenter Study Evaluating the Efficacy and Safety of Pridopidine in Patients with Early Stage of Huntington Disease

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High vs. Standard Dose Influenza Vaccine in Adult SOT Recipients

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Serial Monitoring of Circulating Tumor Cells During Radiotherapy for Women with Non-Metastatic Breast Cancer: A Prospective Observational Cohort Study

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A multicenter, double-blind, randomized study to evaluate the effects of tasimelteon vs. placebo in participants with Delayed Sleep-Wake Phase Disorder (DSWPD)

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Glycemic Observation and Metabolic Outcomes in Mothers and Offspring

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(xIRB) NCI CIRB ECOG-ACRIN 8191: Phase III Study of PET-Directed Local or Systemic Therapy Intensification in Prostate Cancer Patients with Post-Prostatectomy Biochemical Recurrence

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Social Correlates Of Variation In Intestinal And Oral Microbiome Among Hematopoietic Stem Cell Transplant Patients: A Geographic Exploration In The City Of Chicago

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Depression MRI Research Study

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(xIRB) DRUG BB2121-EAP-001: Expanded Access Protocol (EAP) for Subjects Receiving Idecabtagene Vicleucel That Is Nonconforming for Commercial Release

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DRUG Q702-ONC-P1-US001 A Phase 1 Multicenter, Open-label, Dose-Escalation, Safety, Pharmacodynamic, Pharmacokinetic Study of Q702 with a Cohort Expansion at the RP2D in Patients with Advanced Solid Tumors

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Neural Correlates of Acute Pain Dynamics

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NAV3-32: A Comparison of Tc 99m Tilmanocept Quantitative Imaging with Immunohistochemical (IHC) Analysis of CD206 Expression in Synovial Tissue from Subjects Clinically Diagnosed with Rheumatoid Arthritis (RA)

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(xIRB) NCI CIRB NRG BN009: Phase III Trial of Salvage Stereotactic Radiosurgery (SRS) or SRS + Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) for First or Second Distant Brain Relapse After Upfront SRS With Brain Metastasis Velocity >/= 4 Brain Metastases/Year

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A Double-Blind Placebo-Controlled, Randomized 18-Month Phase 2A Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinectics of Oral UCB0599 in Study Participants with Early Parkinson’s Disease

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Catalyst

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Precision MRI of Left Atrial Fibrosis for Patients with Atrial Fibrillation

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Evaluating Fenofibrate for Prevention of Diabetic Retinopathy Worsening

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DAPA ACT HF-TIMI 68

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Stimulating neuroplasticity in TBI with acute intermittent hypoxia

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DRUG JCAR017-EAP-001: Expanded Access Protocol (EAP) for Patients Receiving Lisocabtagene Maraleucel That Is Nonconforming for Commercial Release

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xIRB TRC-PAD Program: In-Clinic Trial-Ready Cohort

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NRG GU009: Parallel Phase III Randomized Trials for High Risk Prostate Cancer Evaluating De-Intensification for Lower Genomic Risk and Intensification of Concurrent Therapy for Higher Genomic Risk with Radiation (PREDICT-RT*)

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A multi-center single arm Phase II study to evaluate the safety and efficacy of genetically engineered autologous cells expressing anti-CD20 and anti-CD19 specific chimeric antigen receptor in subjects with relapsed and/or refractory diffuse large B cell lymphoma (DLBCL)

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PLS Natural History Study (PNHS)

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Web-based Automated Imaging Differentiation of Parkinsonism

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MRI vs Echo: MR-TR

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(xIRB) NCI CIRB ETCTN 10285: Phase 1/2 Study of an EZH2 Inhibitor (Tazemetostat) in Combination with Dual BRAF/MEK Inhibition in Patients with BRAF- Mutated Metastatic Melanoma Who Progressed on Prior BRAF/MEK Inhibitor Therapy

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(xIRB) NCI CIRB SWOG 1925: Randomized, Phase III Study of Early Intervention with Venetoclax and Obinutuzumab Versus Delayed Therapy with Venetoclax and Obinutuzumab in Newly Diagnosed Asymptomatic High-Risk Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): EVOLVE CLL/SLL Study

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(xIRB) NCI CIRB Alliance A011801: The COMPASSHER2 Trials (COMprehensive Use of Pathologic Response ASSessment to Optimize Therapy in HER2-Positive Breast Cancer): COMPASSHER2 Residual Disease (RD), A Double-Blinded, Phase III Randomized Trial of T-DM1 and Placebo Compared with T-DM1 and Tucatinib

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NU MSK20C04: PROTECT Study: A Phase II, Open-Label Trial of PROphylactic Skin Toxicity ThErapy with Clindamycin and Triamcinolone in Glioblastoma Patients Treated with Tumor Treating Fields

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(xIRB) NU MC21B02: Phase IIB Randomized Trial of Oral Tamoxifen vs. Topical 4-hydroxytamoxifen gel vs. Control in Women with Atypical Hyperplasia or Lobular Carcinoma In Situ

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DRUG KN035SAR201: ENVASARC: A Pivotal Trial of Envafolimab, and Envafolimab in Combination with Ipilimumab, in Patients with Advanced or Metastatic Undifferentiated Pleomorphic Sarcoma or Myxofibrosarcoma Who Have Progressed on Prior Chemotherapy

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(XIRB) Drug R5668-ONC-1938: Phase 1/2 Study of REGN5668 (MUC16 X CD28, a Costimulatory Bispecfic) Administered in Combination with Cemiplimab OR REGN4018 (MUC16 X CD3)

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(xirb) Drug BGB-11417-101: A Phase 1/1b Open-Label Dose Escalation and Expansion Study of Bcl-2 Inhibitor BGB-11417 in Patients with Mature B-Cell Malignancies

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NU NCI 20C06: Phase II Trial of the Immune Checkpoint Inhibitor Nivolumab in Patients with Recurrent Select Rare CNS Cancers

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Health Literacy and Cognitive Function among Middle-Aged Adults: The MidCog Study

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Robotic Interventions for Spasticity Treatment

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Prospective, Randomized Study to Assess the Patient Satisfaction, Morbidity, and Stone Free Effect of High-Powered Stone Dusting vs. Fragmentation and Basketing at Time of Ureteroscopy

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(xIRB) NU MC21B04: Genetic Risk Estimation of Breast Cancer Prior to Decisions on Preventive Therapy Uptake, Risk Reducing Surgery or Intensive Imaging Surveillance: A Study to Determine if a Polygenic Risk Score Influences the Decision Making Options Amongst High Risk Women

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Training Swallowing Initiation during Expiration: Impact on Safety and Efficiency Following Treatment for Oropharyngeal Head and Neck Cancer

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(xIRB) DRUG MORAb 202-G000-201: A Multicenter, Open-Label Phase 1/2 Trial Evaluating the Safety, Tolerability, and Efficacy of MORAb-202, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC) in Subjects With Selected Tumor Types

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A5386: Il-15 Superagonist with and without bNAbs to induce HIV control

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XIRB A randomized, two-arm, placebo-controlled, participant and investigator-blinded study investigating the efficacy, safety and tolerability of DFV890 in patients with symptomatic knee osteoarthritis

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xIRB Evaluation of Applaud Medical’s Acoustic Enhancer with Laser Lithotripsy in the Treatment of Urinary Stones

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NU 21B01: Volumetric Lumpectomy Specimen Image Visualization for Intraoperatively Directing Cavity Shaves, a Phase II Study (VIVID)

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The PROMISE Study: PROspective study of Mothers’ and Infants’ Social and Epidemiologic determinants of health

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COAST

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CY6022

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A Phase 3 Randomized, Placebo-Controlled Trial With a Longitudinal Natural History Run-In and Open-Label Extension to Evaluate BIIB067 Initiated in Clinically Presymptomatic Adults With a Confirmed Superoxide Dismutase 1 Mutation

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A phase 1, open-label, safety and dosing study of autologous desmoglein 3 chimeric autoantibody receptor T cells (DSG3-CAART) in subjects with active, anti-DSG3, mucosal-dominant pemphigus vulgaris

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A Prospective, Randomized Controlled Trial Investigating Pecs Blocks Types I and II as a Method for Administering the Non-Opioid Anesthetic Exparel in Order to Mitigate Postoperative Pain, Narcotic Usage and Hospital Stay in Patients Undergoing Implant-Based Tissue Expander Breast Reconstruction Surgery.

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PROTECT IV Trial

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MACITEPH

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Clinical Trial of Approaches to Prostate Cancer Surgery

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IMPACT-Pain-RA

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LUX-Dx TRENDS

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NU 20H09: Phase II, Single-arm, Open-label, Multicenter study Evaluating the Efficacy of Adjunctive Zanubrutinib and CAR T-cell therapy in Aggressive B-cell Non-Hodgkin’s Lymphoma

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NU SARC041

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A PHASE IIB, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF INTRAVENOUS PRASINEZUMAB IN PARTICIPANTS WITH EARLY PARKINSON'S DISEASE

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VIVA MIND Study

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A Phase 3 Study of Tapinarof for the Treatment of Plaque Psoriasis in Pediatric Subjects

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NU 21C01: A phase 1/1b adaptive dose escalation study of mycophenolate mofetil (MMF) in combination with standard of care for patients with glioblastoma

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Testing of bevacizumab, erlotinib, and atezolizumab in combination for advanced-stage kidney cancer

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PROMOTER

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Investigation of Sleep and Health Outcomes in Women Reporting Normal and Heavy Menses Flow

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Drug BNT152-01C: Phase I, first-in-human, open-label, dose escalation trial to evaluate safety, pharmacokinetics, pharmacodynamics, and anti-tumor activity of BNT152+153 in patients with solid tumors

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NRG GU010: PARALLEL PHASE III RANDOMIZED TRIALS OF GENOMICRISK STRATIFIED UNFAVORABLE INTERMEDIATE RISK PROSTATE CANCER: DE-INTENSIFICATION AND INTENSIFICATION CLINICAL TRIAL EVALUATION (GUIDANCE)

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Veri-T Study

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Assessment of Follitropin Delta Efficacy and Safety for Treatment of Men with Idiopathic Infertility

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Impella BTR EFS

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Phase II Multicenter Study of Ruxolitinib in Relapsed or Refractory T or NK Cell Lymphoma

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RADIANCE Continued Access Protocol (RADIANCE CAP)

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REBIRTH

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Cholesterol and Metabolism of CYP3A4/5 Across Pregnancy

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LID

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Endeavor to Stop Nausea/Vomiting Associated with Pregnancy

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NU 22H01: Serial Monitoring of Circulating Plasma Cells and Plasma Cell Components in Adults with Plasma Cell Disorders

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The Role of Low Testosterone in Perioperative Surgical Outcomes

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Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults (PREVENTABLE)

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NU DF21B07: Evaluation of talazoparib, a PARP inhibitor, in patients with somatic BRCA mutant metastatic breast cancer: genotyping based clinical trial

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(xIRB NCI CIRB) ECOG-ACRIN 9213: A Phase II Study of Daratumumab-Hyaluronidase for Chemotherapy-Relapsed/Refractory Minimal Residual Disease (MRD) in T Cell Acute Lymphoblastic Leukemia (T-ALL)

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Evaluating the PD-1 checkpoint inhibitor, Cemiplimab, as neoadjuvant therapy in high risk localized, locally recurrent, and regionally advanced cutaneous squamous cell carcinoma: a Phase II pilot study (NeoPOWER)

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The MOOD study – external Combined Occipital and Trigeminal Nerve Stimulation (eCOT-NS) for the treatment of Major Depressive Disorder (MDD)

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SWOG 2015: Melanoma Margins Trial (MelMarT): A Phase III, Multi-Centre, Multi-National Randomised Control Trial Investigating 1cm v 2cm Wide Excision Margins for Primary Cutaneous Melanoma

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NU-Age Research Registry

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STELLAR

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Pippa Fitness Pessary Clinical Trial

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A Multi-Center, Prospective, Observational Study of Patients Being Treated with ORGOVYX®

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(xIRB NCI CIRB) Alliance A211801: BRCA-P: A Randomized, Double-Blind, Placebo-Controlled, Multi-Center, International Phase 3 Study to determine the Preventive Effect of Denosumab on Breast Cancer in Women carrying a BRCA1 Germline Mutation

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Comparison of NRX-101 to Standard of Care for Bipolar Depression with Subacute Suicidal Ideation and Behavior

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(xIRB NCI CIRB) NRG GI008: Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-NORTH AMERICA)

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SWOG 1918

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A Randomized Phase 3 trial of Nivolumab(NSC# 748726 IND# 125462) in Combination with Chemo-immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-cell Lymphoma

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Arm and leg cycling for accelerated recovery from SCI

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(xIRB NCI CIRB) NRG GY026: A Phase II/III Study of Paclitaxel/Carboplatin Alone or Combined with Either Trastuzumab and Hyaluronidase-oysk (HERCEPTIN HYLECTA) or Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf (PHESGO) in HER2 Positive, Stage I-IV Endometrial Serous Carcinoma or Carcinosarcoma

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DRUG IMGN853-0420: Multicenter, open-label, phase 2 study of carboplatin plus mirvetuximab soravtansine followed by mirvetuximab soravtansine continuation in folate receptor-alpha positive, recurrent platinum-sensitive, high-grade epithelial ovarian, primary peritoneal, or fallopian tube cancers following 1 prior line of platinum-based chemotherapy

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PERSEVERE

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NU 22I05

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DEFINE-HT

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DREAM Study

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LeAAPS Trial

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Study for Desensitization of Chronic Kidney Disease Adult Patients in Need of a Kidney Transplant Who Are Highly Sensitized to Human Leukocyte Antigen

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REHAB-HFpEF

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(PEAK) A Phase 3 Randomized, Open-label, Multicenter Clinical Study of CGT9486 + Sunitinib vs Sunitinib in Subjects with Locally Advanced, Unresectable or Metastsatic Gastrointestinal Stromal Tumors

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NU 22MH03: Phase II open-label multi-cohort study evaluating CPI-613 (devimistat) in combination with hydroxychloroquine and 5-fluorouracil or gemcitabine in patients with advanced chemorefractory colorectal, pancreatic, or other solid cancers

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A Single-Arm Phase II Study of Personalized Dose Guidance for Stereotactic Body Radiotherapy (SBRT) in Patients with Lung Tumors, The RADiotherapy Augmented Intelligence Trial (RAD-AI)

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High vs. Standard Dose Influenza Vaccine in Lung Allograft Recipients

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NRG BN012

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DRUG GS-US-592-6238

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SWOG 2200: A Phase II Randomized Trial of Cabozantinib (NSC #761968) with or Without Atezolizumab (NSC #783608) in Patients with Advanced Papillary Renal Cell Carcinoma (PAPMET2)

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Characterizing dysfunction of cerebral arteries in neurodegenerative diseases using high resolution MRI

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A Randomized Phase II/III Trial of Modern Immunotherapy Based Systemic Therapy with or Without SBRT for PD-L1-Negative, Advanced Non-Small Cell Lung Cancer

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Heart-Brain MRI Evaluation

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Metabolomic Signatures associated with Adverse Pregnancy Outcomes and Social Determinants of Health (MASH)

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ASL in Cerebrovascular Disease

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RESET-RA

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ADVANTAGE-AF

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SWOG 2104: Randomized Phase II Trial of Postoperative Adjuvant Capecitabine and Temozolomide versus Observation in High-Risk Pancreatic Neuroendocrine Tumors

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NU 22S08: Northwestern Sarcoma Biorepository and Clinical Database

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Multi-center, Noninterventional Study Evaluating Variability, Reliability, and Compliance for the Parkinson’s Disease Diary

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ACR-368-201: A Phase 1b/2 Basket Study of ACR-368 as Monotherapy and in Combination With Gemcitabine in Adult Subjects With Platinum-Resistant Ovarian Carcinoma, Endometrial Adenocarcinoma, and Urothelial Carcinoma Based on Acrivon OncoSignature® Status

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DRUG GS-US-592-6173

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Phase 1 Study of Erdafitinib Intravesical Delivery System (TAR-210) in Participants with Non-Muscle-Invasive or Muscle-Invasive Bladder Cancer and Selected FGFR Mutations or Fusions

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ETCTN 10492

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(xIRB) DRUG BDTX-1535-101: A Phase 1 Study to Assess BDTX-1535, an Oral EGFR Inhibitor, in Patients with Glioblastoma or Non-Small Cell Lung Cancer

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Quantitative Cerebral Blood Vessel Imaging Biomarkers for AD (Alzheimer's Disease) and VCID (Vascular Cognitive Impairment and Dementia)

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RESPONDER-HF

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THE CHICAGO PERINATAL ORIGINS OF DISEASE COHORT AND THE FOUNDER'S 400

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Phase II Randomized, Prospective Trial of Lutetium Lu 177 Dotatate PRRT Versus Capecitabine and Temozolomide in Well-Differentiated Pancreatic Neuroendocrine Tumors

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DRUG CL1-95032-005: A Phase 1, Safety Lead-in and Randomized, Open-label, Perioperative Study of Vorasidenib in Combination with Pembrolizumab in Subjects with Recurrent or Progressive Enhancing IDH-1 Mutant Astrocytomas

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(xIRB) DRUG GLSI-21-01: A Randomized, Multicenter, Placebo-controlled, Phase 3 study to Evaluate the Efficacy and Safety of HER2/neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/neu Positive Subjects with Residual Disease or High-Risk PCR after both Neoadjuvant and Postoperative Adjuvant Trastuzumab-based Therapy (FLAMINGO-01)

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A randomized, double-blind, placebo-controlled Phase 3 study of darolutamide plus androgen deprivation therapy (ADT) compared with placebo plus ADT in patients with high-risk biochemical recurrence (BCR) of prostate cancer

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ETCTN 10496

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Alliance A092104

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Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD

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Biceps muscle properties in healthy and tendon repair populations

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DRUG ARV-766-mCRPC-101

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A Multicenter Phase I/Ib Dose Escalation Study of WTX-124 as Monotherapy and in Combination with Pembrolizumab in Patients with Selected Advanced or Metastatic Solid Tumors

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DRUG QRNT-009: A Phase 1/2 Multicenter, Open-label, Dose-escalation, Safety, Pharmacodynamic, and Pharmacokinetic Study of Q901 Administered via Intravenous Infusion in Adult Patients with Selected Advanced Solid Tumors with a Cohort Expansion at the Recommended Phase 2 Dose

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DRUG XMAB808-01: A Phase 1, First-in-Human, Dose-Finding and Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Activity of XmAb®808 in Combination with Pembrolizumab in Selected Advanced Solid Tumors

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SOUND Pivotal Trial– Sonomotion stOne comminUtion resoNance ultrasounD Pivotal Trial

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Development and Validation of an Ancillary Diagnostic Test for Mycosis Fungoides (SIGNAL MF)

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(xIRB) DRUG 213304: Expanded Access Program for belantamab mafodotin in Patients with Relapsed/Refractory Multiple Myeloma who are Refractory to a Proteasome Inhibitor, and an Immunomodulatory Agent, and an Anti-CD38 Antibody

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Alliance A032101: A Phase 2 Trial of ADT Interruption in Patients Responding Exceptionally to AR-Pathway Inhibitor in Metastatic Hormone-Sensitive Prostate Cancer (MHSPC): A-DREAM

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Fit4Treatment

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SWOG 2302: A Prospective Randomized Study of Ramucirumab plus Pembrolizumab versus Standard of Care for Participants Previously Treated with Immunotherapy for Stage IV or Recurrent Non-Small Cell Lung Cancer.

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Treatment for Pruitis in Primary Biliary Cholangitis (PBC).

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REACT-AF

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DRUG KEYVIBE-010: A Phase 3, Randomized, Double-blind, Active- Comparator-Controlled Clinical Study of Adjuvant MK-7684A (Vibostolimab with Pembrolizumab) Versus Adjuvant Pembrolizumab in Participants with High-risk Stage II-IV Melanoma (KEYVIBE010)

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DRUG D8410C00001: A Modular Phase I/IIa, Open-Label, Multi-centre Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of Ascending Doses of AZD9574 as Monotherapy and in Combination with Anti-cancer Agents in Patients with Advanced Solid Malignancies (CERTIS1)

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Testing the addition of an anti-cancer drug, irinotecan, to the standard chemotherapy treatment (FOLFOX) after long-course radiation therapy for advanced-stage rectal cancers to improve the rate of complete response and long-term rates of organ preservation

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DRUG OM-GRPR1-02: A Phase 1 Open-Label Dose Escalation and Expansion Study to Determine the Safety, Tolerability, Dosimetry, and Preliminary Efficacy of 212Pb-DOTAM-GRPR1 in Adult Subjects with Recurrent or Metastatic GRPR-expressing Tumors

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Alliance A051902

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(xIRB) DRUG U31402-A-U103: A PHASE 1 OPEN-LABEL STUDY OF PATRITUMAB DERUXTECAN (U3-1402) IN COMBINATION WITH OSIMERTINIB IN SUBJECTS WITH LOCALLY ADVANCED OR METASTATIC EGFR-MUTATED NONSMALL CELL LUNG CANCER (NSCLC) (PATRITUMAB DERUXTECAN [U3-1402] IN COMBINATION WITH OSIMERTINIB IN SUBJECTS WITH LOCALLY ADVANCED OR METASTATIC EGFR-MUTATED NON-SMALL CELL LUNG CANCER [NSCLC])

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DRUG NX-5948-301: A Phase 1, Dose Escalation, and Cohort Expansion Study Evaluating NX-5948, a Bruton’s Tyrosine Kinase (BTK) Degrader, in Adults with Relapsed/Refractory B-cell Malignancies

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(xIRB) DRUG SGNTV-001: Open Label Phase 2 Study of Tisotumab Vedotin for Locally Advanced or Metastatic Disease in Solid Tumors

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Nautika1: Multicenter, Phase II, Neoadjuvant and Adjuvant Study of Multiple Therapies in Biomarker-Selected Patients With Resectable Stages IB-III Non-Small Cell Lung Cancer

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DRUG M20-638: A Phase 3, Open-Label Study to Evaluate Safety and Efficacy of Epcoritamab in Combination with Rituximab and Lenalidomide (R2) compared to R2 in Subjects with Relapsed or Refractory Follicular Lymphoma (EPCORE™ FL-1)

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DRUG 19-12021154

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DRUG CDRB436J12301

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NU MSK22H05: Phase 2 study of Zanubrutinib, Obinutuzumab, and Venetoclax in Previously Untreated Patients with Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) and Mantle Cell Lymphoma (MCL)

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CCTG HN11

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Northwestern Myositis Registry and Biorepository

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Join the ADNI-4 Study

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SWOG 2010

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(XIRB) DRUG SGNBB228-001: A phase 1 study of SGN-BB228 in advanced melanoma and solid tumors

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DRUG R3767-ONC-2055: A Phase 3 Trial of Fianlimab (anti-LAG-3) and Cemiplimab versus Pembrolizumab in the Adjuvant Setting in Patients with Completely Resected High-risk Melanoma

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uTRACT Jelmyto® Registry

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DRUG CA-4948-102: A phase 1/2a, open-label dose escalation and cohort expansion study of orally administered ca-4948 (irak4i) as a monotherapy in patients with acute myelogenous leukemia or myelodysplastic syndrome and in combination with azacitidine or venetoclax

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DRUG 68284528MMY4006: Intermediate-Size Population Expanded Access Program (EAP) for Ciltacabtagene autoleucel (cilta-cel) Out-of-Specification (OOS) in patients with Multiple Myeloma

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Multimodality Therapy with Immunotherapy in Stage I-IIIA Sarcomatoid Mesothelioma

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Combing topical imiquimod with local radiotherapy treatment of mycosis fungoides

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A randomised, double-blind, placebo-controlled, multicentre, Phase 3 study evaluating efficacy and safety of lanifibranor followed by an active treatment extension in adult patients with non-cirrhotic non-alcoholic steatohepatitis (NASH) and fibrosis 2 (F2)/fibrosis 3 (F3) stage of liver fibrosis

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(XIRB) DRUG 001: A Phase 1/1b Open-label, Multicenter Clinical Study of MK-0472 as Monotherapy and Combination Therapy in Participants with Advanced/Metastatic Solid Tumors.

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Molecular Biomarkers to Guide Therapy in the Systemic Sclerosis-Associated Interstitial Lung Disease

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CY 6032

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(xIRB) DRUG STML-ELA-0222: A Phase 1b/2, Open-Label Umbrella Study to Evaluate Safety and Efficacy of Elacestrant in Various Combinations in Patients with Metastatic Breast Cancer (ELEVATE)

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ECOG-ACRIN Y191: Molecular Analysis for Combination Therapy Choice (ComboMATCH)

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(xirb) DRUG Ph2 INBRX-109 SA CS: A Randomized, Blinded, Placebo-controlled, Phase 2 Study of INBRX-109 in Unresectable or Metastatic Conventional Chondrosarcoma

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A Randomized Phase II Study of INC280 (Capmatinib) Plus Osimertinib with or Without Ramucirumab in Participants with EGFR-Mutant, MET-Amplified Stage IV or Recurrent Non-Small Cell Lung Cancer (Lung-MAP Sub-Study)

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ECOG-ACRIN EAY191-N2

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Alliance A042001, A Randomized Phase II Study Comparing Inotuzumab Plus Chemotherapy versus Standard Chemotherapy in Older Adults with Philadelphia-Chromosome-Negative B-cell Acute Lymphoblastic Leukemia

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Investigational drug for NASH cirrhosis

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(xIRB NCI IRB) ETCTN 10522: A Phase I Clinical Trial of CA-4948 in Combination with Gemcitabine and Nab-Paclitaxel in Metastatic or Unresectable Pancreatic Ductal Carcinoma

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FAST Study

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LCRF Leader Trial: LCMC4 Evaluation of Actionable Drivers in EaRly Stage Lung Cancer

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(xIRB NCI CIRB) ETCTN 10487: A Phase II Study of Lutetium Lu 177 Dotatate in Metastatic Prostate Cancer with Neuroendocrine Differentiation

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Measuring copper parameters in Wilson's Disease using a novel assay

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(xIRB) DRUG 1454-0001: A first-in-human Phase I, non-randomized, open-label, multicenter dose escalation trial of BI 765049 and BI 765049 +ezabenlimab administered by repeated intravenous infusions in patients with malignant solid tumors expressing B7-H6

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ETCTN 10538: Venetoclax In Combination with ASTX727, an All-ORal TherapY for Chronic Myelomonocytic Leukemia and Other MDS/MPN with Excess Blasts (VICTORY-MDS/MPN): a Randomized, Phase 2 Trial

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A Pilot Study of rhPSMA -PET MRI Imaging For the Detection of Clinically Actionable Prostate Cancer Among Men Who Are Otherwise Candidates for Active Surveillance

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DRUG CTX-009-002: A Phase 2/3 Randomized, Controlled Study of CTX-009 in Combination with Paclitaxel versus Paclitaxel Alone in Adult Patients with Unresectable Advanced, Metastatic or Recurrent Biliary Tract Cancers who have received One Prior Systemic Chemotherapy Regimen

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Blue Light Cystoscopy™ with Cysview® Registry

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DRUG SOLTI-2101

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(xIRB) DRUG EP0031-101: A Modular, Open-label, Phase I/II Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of EP0031 in Patients with Advanced RET-altered Malignancies

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SEISMIC-HF I

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MA-GVHD-401: A Prospective, Observational Cohort Study of Participants at Risk for Chronic Graft-Versus-Host Disease in the United States (THRIVE)

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(xIRB) DRUG BA3182-001: AN OPEN-LABEL, MULTICENTER, PHASE 1 STUDY EVALUATING THE SAFETY, PHARMACOKINETICS, AND EFFICACY OF BA3182, A BISPECIFIC EPITHELIAL CELL ADHESION MOLECULE (EPCAM)/CD3 ANTIBODY, IN PATIENTS WITH ADVANCED ADENOCARCINOMA

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(xIRB NCI CIRB) ECOG-ACRIN EA1211: Interim FDG-PET/CT for PreDIcting REsponse of HER2+ Breast Cancer to Neoadjuvant Therapy: DIRECT Trial

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Testing the effectiveness of an anti-cancer drug, triapine, when used with targeted radiation-based treatment (Lutetium Lu 177 Dotatate), compared to Lutetium Lu 177 Dotatate alone for metastatic neuroendocrine tumors

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Hair Disorder Registry

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IMVT-1401-3201

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(xIRB NCI CIRB) CCTG NE1: NET RETREAT: A Phase II Study of 177 Lutetium-DOTATATE Retreatment vs. Everolimus in Metastatic/Unresectable Midgut NET

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DRUG POLARIS2022-001

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A Phase 2 Evaluation of the Safety and Efficacy of AL8326 in =2nd Line Small Cell Lung Cancer (SCLC) Treatment

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ECOG-ACRIN 7211

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CY 6033 ACACIA

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NU 23H06: A Phase II multi-center open-label trial of six doses of pembrolizumab monotherapy prior to limited chemotherapy as front-line therapy for patients with classical Hodgkin lymphoma, including elderly patients

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RGN-NK-302

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(XIRB) DRUG TOS-358-001: A Study to Evaluate the Safety and Tolerability of the Covalent Phosphoinositide-3-Kinase (PI3K)-alpha Inhibitor, TOS-358, in Adult Subjects with Select Solid Tumors

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DRUG J2J-MC-JZLH: EMBER-4: A Randomized, Open-Label, Phase 3 Study of Adjuvant Imlunestrant vs Standard Adjuvant Endocrine Therapy in Patients who have Previously Received 2 to 5 years of Adjuvant Endocrine Therapy for ER+, HER2- Early Breast Cancer with an Increased Risk of Recurrence

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(XIRB) DRUG PTG-300-11: A Phase 3 Study of the Hepcidin Mimetic Rusfertide (PTG-300) in Patients with Polycythemia Vera (PTG-300-11)

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SWOG 2212: Shorter Anthracycline-Free Chemo Immunotherapy Adapted to Pathological Response in Early Triple Negative Breast Cancer (SCARLET), A Randomized Phase III Study

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(xIRB NCI IRB) SWOG 2012: Randomized Phase II/III Trial of First Line Platinum/Etoposide with or Without Atezolizumab (NSC#783608) in Patients with Poorly Differentiated Extrapulmonary Small Cell Neuroendocrine Carcinomas (NEC)

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Phase III Prospective Randomized Trial of Primary Lung Tumor Stereotactic Body Radiation Therapy Followed by Concurrent Mediastinal Chemoradiation for Locally-Advanced Non-Small Cell Lung Cancer

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NU 23B05 - Randomized phase II study of elacestrant vs elacestrant plus a CDK4/6 inhibitor (palbociclib, abemaciclib, or ribociclib) in patients with ER+/HER2- advanced or metastatic breast cancer with prior exposure to a CKD4/6 inhibitor

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Equity in Modifying Plaque Of WomEn with UndeRtreated Calcified Coronary Artery Disease (EMPOWER CAD)

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(xIRB) DRUG CYP-GVHD-P2-01: A Multicenter, Randomized, Double-blind, Placebo-Controlled Phase II Study to Investigate the Efficacy and Safety of CYP-001 in Combination with Corticosteroids vs Corticosteroids Alone for the Treatment of High-Risk Acute Graft Versus Host Disease

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NU 23U08: A Randomized Phase II study of ADT + Abiraterone versus ADT + Docetaxel + Abiraterone in Patients with Low Volume Metastatic Hormone Sensitive Prostate Cancer

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SOAR - Phase III Randomized Trial of Stereotactic Ablative Radiotherapy (SAbR) for Oligometastatic Advanced Renal Carcinoma

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Alliance A012103: OptimICE-PCR: De-Escalation of Therapy in Early-Stage TNBC Patients Who Achieve pCR After Neoadjuvant Chemotherapy with Checkpoint Inhibitor Therapy

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(xIRB NCI CIRB) Alliance A092107: A Randomized Phase 2 Trial with a Safety Lead-In to Evaluate Palbociclib Versus Palbociclib and Cemiplimab for the Treatment of Advanced Dedifferentiated Liposarcoma

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An Open-Label Study of Dupilumab in Adolescent and Adult Skin-of-Color Patients with Moderate-to-Severe Atopic Dermatitis

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EXTEND

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(xIRB) DRUG IMSA101-103: Phase 2 Randomized Clinical Trial Comparing the Safety and Efficacy of PULSAR-Integrated Radiotherapy + Pembrolizumab or Nivolumab Administered with or without STING-Agonist IMSA101 in Patients with Oligoprogressive Solid Tumor Malignancies

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(xIRB) DRUG ALE.C04.01: A Phase I/II, Open-Label, Multi-Center Study of ALE.C04 (anti-Claudin-1 Antibody) as a Single Agent and in Combination with Pembrolizumab (anti- PD-1 antibody) in Adult Patients with Recurrent or Metastatic (R/M) Head and Neck Squamous Cell Carcinoma

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DRUG SBI-BSF-001: Collection of Plasma Samples Using Sodium Heparin from Subjects Undergoing Intravenous Busulfan Treatment

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(xIRB NCI CIRB) SWOG 1905: A Phase I/II Study of AKR1C3-Activated Prodrug OBI-3424 (OBI-3424) in Patients with Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia (T-ALL)/TCell Lymphoblastic Lymphoma (T-LBL)

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(xIRB) DRUG COVALENT-103: A Phase 1, open-label, dose-escalation, and dose-expansion study of BMF-500, an oral covalent FLT3 inhibitor, in adults with acute leukemia

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ARISE-II

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(xIRB NCI CIRB) Alliance A092105: Randomized Phase 2 Study of Nivolumab and Ipilimumab with or Without Cabozantinib in Patients with Advanced Nasopharyngeal Carcinoma That Have Progressed After Platinum Treatment and Immunotherapy

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DRUG KT-US-472-0141

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NRG GU013: The Phase III ‘High Five Trial’ Five Fraction Radiation For High-Risk Prostate Cancer

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DRUG EDGE-Lung: A Phase II, Open-label, Platform Study, to Evaluate Immunotherapy-based Combinations in Participants With Advanced Non-Small Cell Lung Cancer

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A Phase 1/2 Study of Nivolumab and Ipilimumab in Combination with Sirolimus and Prednisone in Kidney Transplant Recipients with Selected Unresectable or Metastatic Cutaneous Cancers

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(xIRB NCI CIRB) ETCTN 10347: A phase I study with an expansion cohort of duvelisib and nivolumab in mycosis fungoides (MF) and Sézary syndrome (SS)

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Preserve Heart Study

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NRG BR009

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A Phase 3, Open-Label, Multi-Center, Randomized Study Evaluating the Efficacy and Safety of TAR-200 in Combination with Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants with BCG-naïve High-Risk Non-Muscle Invasive Bladder Cancer (HR-NMIBC)

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Study to understand the safety and efficacy of an experimental oral drug for HS

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ALT-FLOW II

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Testing the role of DNA released from tumor cells into the blood in guiding the use of immunotherapy after surgical removal of the bladder for bladder cancer treatment.

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ETCTN 10601

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A Randomized Open label Phase II Trial of FDG-PETguided Metastasis Directed Therapy in Patients With Metastatic Hormone Sensitive Prostate Cancer: PRTY trial: PET- Guided RadioTherapY consolidation

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