High-Impact-Factor Research 2019

Banerjee S, Gusho E, Gaughan C, Dong BH, Gu XR, Holvey-Bates E, Talukdar M, Li YZ, Weiss SR, Sicheri F, Saunthararajah Y, Stark GR, Silverman RH. OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug. Proceedings of the National Academy of Sciences of the United States of America. 2019 Mar;116(11):5071-5076.

Chang BJ, Kittisopikul M, Dean KM, Roudot P, Welf ES, Fiolka R. Universal light-sheet generation with field synthesis. Nature Methods. 2019 Mar;16(3):235-238.

Chen PC, Liu MH, Du JSS, Meckes B, Wang SZ, Lin HX, Dravid VP, Wolverton C, Mirkin CA. Interface and heterostructure design in polyelemental nanoparticles. Science. 2019 Mar;363(6430):959.

Chung HU, Kim BH, Lee JY, Lee J, Xie ZQ, Ibler EM, Lee K, Banks A, Jeong JY, Kim J, Ogle C, Grande D, Yu Y, Jang H, Assem P, Ryu D, Kwak JW, Namkoong M, Park JB, Lee Y, Kim DH, Ryu A, Jeong J, You K, Ji BW, Liu ZJ, Huo QZ, Feng X, Deng YJ, Xu YS, Jang KI, Kim J, Zhang YH, Ghaffari R, Rand CM, Schau M, Hamvas A, Weese-Mayer DE, Huang YG, Lee SM, Lee CH, Shanbhag NR, Paller AS, Xu S, Rogers JA.Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care. Science. 2019 Mar;363(6430):947.

Crowley JJ, Szatkiewicz J, Kahler AK, Giusti-Rodriguez P, Ancalade N, Booker JK, Carr JL, Crawford GE, Losh M, Stockmeier CA, Taylor AK, Piven J, Sullivan PF. Common-variant associations with fragile X syndrome. Molecular Psychiatry. 2019 Mar;24(3):338-344.

Hoeman CM, Cordero FJ, Hu G, Misuraca K, Romero MM, Cardona HJ, Nazarian J, Hashizume R, McLendon R, Yu P, Procissi D, Gadd S, Becher OJ. ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis. Nature Communications. 2019 Mar;10:15.

Hoxhaj G, Ben-Sahra I, Lockwood SE, Timson RC, Byles V, Henning GT, Gao P, Selfors LM, Asara JM, Manning BD. Direct stimulation of NADP(+) synthesis through Akt-mediated phosphorylation of NAD kinase. Science. 2019 Mar;363(6431):1088.

Hu YM, Li M, Lu QS, et.al. (including Weintraub S.)A statistical framework for cross-tissue transcriptome-wide association analysis. Nature Genetics. 2019 Mar;51(3):568.

Krenzlin H, Behera P, Lorenz V, Passaro C, Zdioruk M, Nowicki MO, Grauwet K, Zhang H, Skubal M, Ito H, Zane R, Gutknecht M, Griessl MB, Ricklefs F, Ding L, Peled S, Rooj A, James CD, Cobbs CS, Cook CH, Chiocca EA, Lawler SE. Cytomegalovirus promotes murine glioblastoma growth via pericyte recruitment and angiogenesis. Journal of Clinical Investigation. 2019 Mar 11;130:1671-1683.

Kunkle BW, Grenier-Boley B, Sims R, et al. (including Bigio EH, Mesulam M, Weintraub S). Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Abeta, tau, immunity and lipid processing. Nature Genetics. 2019 Mar;51(3):414-430.

LeBleu VS, Kalluri R. Exosomes Exercise Inhibition of Anti-Tumor Immunity during Chemotherapy. Immunity. 2019 Mar;50(3):547-549.

Levine CS, Markus HR, Austin MK, Chen E, Miller GE. Students of color show health advantages when they attend schools that emphasize the value of diversity. Proceedings of the National Academy of Sciences of the United States of America. 2019 Mar;116(13):6013-6018.

Levine DM, Landon BE, Linder JA. Quality and Experience of Outpatient Care in the United States for Adults With or Without Primary Care. JAMA Internal Medicine. 2019 Mar;179(3):363-372.

McSharry SS, Beitel GJ. The Caspase-3 homolog DrICE regulates endocytic trafficking during Drosophila tracheal morphogenesis. Nature Communications. 2019 Mar;10:10.

O'Donnell M, Mente A, Rangarajan S, McQueen MJ, O'Leary N, Yin L, Liu XY, Swaminathan S, Khatib R, Rosengren A, Ferguson J, Smyth A, Lopez-Jaramillo P, Diaz R, Avezum A, Lanas F, Ismail N, Yusoff K, Dans A, Iqbal R, Szuba A, Mohammadifard N, Oguz A, Yusufali AH, Alhabib KF, Kruger IM, Yusuf R, Chifamba J, Yeates K, Dagenais G, Wielgosz A, Lear SA, Teo K, Yusuf S, Investigators P. Joint association of urinary sodium and potassium excretion with cardiovascular events and mortality: prospective cohort study. BMJ-British Medical Journal. 2019 Mar;364:14.

Piccini JP, Xu H, Cox M, Matsouaka RA, Fonarow GC, Butler J, Curtis AB, Desai N, Fang M, McCabe PJ, Page Ii RL, Turakhia M, Russo AM, Knight BP, Sidhu M, Hurwitz JL, Ellenbogen KA, Lewis WR. Adherence to Guideline-Directed Stroke Prevention Therapy for Atrial Fibrillation Is Achievable.Circulation. 2019 Mar 19;139(12):1497-1506.

Zhao J, Chen AX, Gartrell RD, Silverman AM, Aparicio L, Chu T, Bordbar D, Shan D, Samanamud J, Mahajan A, Filip I, Orenbuch R, Goetz M, Yamaguchi JT, Cloney M, Horbinski C, Lukas RV, Raizer J, Rae AI, Yuan JZ, Canoll P, Bruce JN, Saenger YM, Sims P, Iwamoto FM, Sonabend AM, Rabadan R. Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma. Nature Medicine. 2019 Mar;25(3):462.

Zhong VW, Van Horn L, Cornelis MC, Wilkins JT, Ning HY, Carnethon MR, Greenland P, Mentz RJ, Tucker KL, Zhao LH, Norwood AF, Lloyd-Jones DM, Allen NB. Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Disease and Mortality. JAMA-Journal of the American Medical Association. 2019 Mar;321(11):1081-1095.

Zhou GY, Lane G, Notoe T, Arabkheradmand G, Gottfried JA, Schuele SU, Rosenow JM, Olofsson JK, Wilson DA, Zelano C. Human olfactory-auditory integration requires phase synchrony between sensory cortices. Nature Communications. 2019 Mar;10:12.

Butin-Israeli V, Bui TM, Wiesolek HL, Mascarenhas L, Lee JJ, Mehl LC, Knutson KR, Adam SA, Goldman RD, Beyder A, Wiesmuller L, Hanauer SB, Sumagin R.Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing. Journal of Clinical Investigation. 2019 Feb 1;129(2):712-726.

Cella D, Grunwald V, Escudier B, Hammers HJ, George S, Nathan P, Grimm MO, Rini BI, Doan J, Ivanescu C, Paty J, Mekan S, Motzer RJ. Patient-reported outcomes of patients with advanced renal cell carcinoma treated with nivolumab plus ipilimumab versus sunitinib (CheckMate 214): a randomised, phase 3 trial. Lancet Oncology. 2019 Feb;20(2):297-310.

Curry SJ, Krist AH, Owens DK, Barry MJ, Caughey AB, Davidson K, Doubeni CA, Epling JW, Grossman DC, Kemper AR, Kubik M, Landefeld CS, Mangione CM, Silverstein M, Simon MA, Tseng CW, Wong JB, Force USPST. Interventions to Prevent Perinatal Depression US Preventive Services Task Force Recommendation Statement. JAMA. 2019 Feb;321(6):580-587.

Daya M, Rafaels N, Brunetti TM, et al. (including Grammer L). Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations. Nature Communications. 2019 Feb;10:13.

Elfassy T, Swift SL, Glymour MM, Calonico S, Jacobs DR, Mayeda ER, Kershaw KN, Kiefe C, Al Hazzouri AZ. Associations of Income Volatility With Incident Cardiovascular Disease and All-Cause Mortality in a US Cohort 1990 to 2015. Circulation. 2019 Feb;139(7):850-859.

Frey TM, Florin TA, Caruso M, Zhang NH, Zhang Y, Mittiga MR. Effect of Intranasal Ketamine vs Fentanyl on Pain Reduction for Extremity Injuries in Children The PRIME Randomized Clinical Trial. JAMA Pediatrics. 2019 Feb;173(2):140-146.

Gerson JN, Handorf E, Villa D, Gerrie AS, Chapani P, Li S, Medeiros LJ, Wang MI, Cohen JB, Calzada O, Churnetski MC, Hill BT, Sawalha Y, Hernandez-Ilizaliturri FJ, Kothari S, Vose JM, Bast MA, Fenske TS, Gari SNR, Maddocks KJ, Bond D, Bachanova V, Kolla B, Chavez J, Shah B, Lansigan F, Burns TF, Donovan AM, Wagner-Johnston N, Messmer M, Mehta A, Anderson JK, Reddy N, Kovach AE, Landsburg DJ, Glenn M, Inwards DJ, Karmali R, Kaplan JB, Caimi PF, Rajguru S, Evens A, Klein A, Umyarova E, Pulluri B, Amengual JE, Lue JK, Diefenbach C, Fisher RI, Barta SK. Survival Outcomes of Younger Patients With Mantle Cell Lymphoma Treated in the Rituximab Era. Journal of Clinical Oncology. 2019 Feb;37(6):471.

Laramy CR, Lopez-Rios H, O'Brien MN, Girard M, Stawicki RJ, Lee B, de la Cruz MO, Mirkin CA. Controlled Symmetry Breaking in Colloidal Crystal Engineering with DNA. ACS Nano. 2019 Feb;13(2):1412-1420.

Lazic D, Sagare AP, Nikolakopoulou AM, Griffin JH, Vassar R, Zlokovic BV. 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice. Journal of Experimental Medicine. 2019 Feb 4;216(2):279-293.

Liu M, Jiang Y, Wedow R, (including Cornelis MC). Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Nature Genetics. 2019 Feb;51(2):237-244.

Li WJ, Gauthier JM, Higashikubo R, Hsiao HM, Tanaka S, Vuong L, Ritter JH, Tong AY, Wong BW, Hachem RR, Puri V, Bharat A, Krupnick AS, Hsieh CS, Baldwin WM, Kelly FL, Palmer SM, Gelman AE, Kreisel D. Bronchus-associated lymphoid tissue-resident Foxp3(+) T lymphocytes prevent antibody-mediated lung rejection. Journal of Clinical Investigation. 2019 Feb;129(2):556-568.

McCann ME, de Graaff JC, Dorris L, et al. (including Surantham S). Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial. Lancet. 2019 Feb;393(10172):664-677.

Nan KW, Wang HL, Ning X, Miller KA, Wei C, Liu YP, Li HB, Xue YG, Xie ZQ, Luan HW, Zhang YH, Huang YG, Rogers JA, Braun PV. Soft Three-Dimensional Microscale Vibratory Platforms for Characterization of Nano-Thin Polymer Films. ACS Nano. 2019 Jan;13(1):449-457.

Shuen AY, Lanni S, Panigrahi GB, Edwards M, Yu L, Campbell BB, Mandel A, Zhang C, Zhukova N, Alharbi M, Bernstein M, Bowers DC, Carroll S, Cole KA, Constantini S, Crooks B, Dvir R, Farah R, Hijiya N, George B, Laetsch TW, Larouche V, Lindhorst S, Luiten RC, Magimairajan V, Mason G, Mason W, Mordechai O, Mushtaq N, Nicholas G, Oren M, Palma L, Pedroza LA, Ramdas J, Samuel D, Schneider KW, Seeley A, Semotiuk K, Shamvil A, Sumerauer D, Toledano H, Tomboc P, Wierman M, Van Damme A, Lee YY, Zapotocky M, Bouffet E, Durno C, Aronson M, Gallinger S, Foulkes WD, Malkin D, Tabori U, Pearson CE. Functional Repair Assay for the Diagnosis of Constitutional Mismatch Repair Deficiency From Non-Neoplastic Tissue. Journal of Clinical Oncology. 2019 Feb;37(6):461.

Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Budinger GRS. Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis. Cell Metabolism. 2019 Feb;29(2):335.

Song B, Park SH, Zhao JC, Fong KW, Li SZ, Lee Y, Yang YA, Sridhar S, Lu XD, Abdulkadir SA, Vessella RL, Morrissey C, Kuzel TM, Catalona W, Yang XM, Yu JD. Targeting FOXA1-mediated repression of TGF-beta signaling suppresses castration-resistant prostate cancer progression. Journal of Clinical Investigation. 2019 Feb;129(2):569-582.

Tabaries S, McNulty A, Ouellet V, Annis MG, Dessureault M, Vinette M, Hachem Y, Lavoie B, Omeroglu A, Simon HG, Walsh LA, Kimbung S, Hedenfalk I, Siegel PM. Afadin cooperates with Claudin-2 to promote breast cancer metastasis. Genes & Development. 2019 Feb 1;33(3-4):180-193.

Tanimura A, Du YJ, Kondapalli J, Wokosin DL, Surmeier DJ. Cholinergic Interneurons Amplify Thalamostriatal Excitation of Striatal Indirect Pathway Neurons in Parkinson's Disease Models. Neuron. 2019 Feb;101(3):444.

Wang L, Shilatifard A. UTX Mutations in Human Cancer. Cancer Cell. 2019 Feb;35(2):168-176.

Zhang H, Brown RL, Wei Y, Zhao P, Liu S, Liu X, Deng Y, Hu X, Zhang J, Gao XD, Kang Y, Mercurio AM, Goel HL, Cheng C. CD44 splice isoform switching determines breast cancer stem cell state.Genes & Development. 2019 Feb 1;33(3-4):166-179.

Zhang S, Weinberg S, DeBerge M, Gainullina A, Schipma M, Kinchen JM, Ben-Sahra I,Gius DR, Yvan-Charvet L, Chandel NS, Schumacker PT, Thorp EB. Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair.Cell Metabolism. 2019 Feb;29(2):443.

Brown KA, Hedrick JL, Eichelsdoerfer DJ, Mirkin CA.Nanocombinatorics with Cantilever-Free Scanning Probe Arrays. ACS Nano. 2019 Jan;13(1):8-17.

Burt RK, Balabanov R, Burman J, Sharrack B, Snowden JA, Oliveira MC, Fagius J, Rose J, Nelson F, Barreira AA, Carlson K, Han XQ, Moraes D, Morgan A, Quigley K, Yaung K, Buckley R, Alldredge C, Clendenan A, Calvario MA, Henry J, Jovanovic B, Helenowski IB. Effect of Nonmyeloablative Hematopoietic Stem Cell Transplantation vs Continued Disease-Modifying Therapy on Disease Progression in Patients With Relapsing-Remitting Multiple Sclerosis A Randomized Clinical Trial. JAMA. 2019 Jan;321(2):165-174.

Carnethon MR, Neubauer LC, Greenland P. Competency-Based Postdoctoral Education. Circulation. 2019 Jan 15;139(3):310-312.

Chen SQ, Fan J, Zhang MH, Qin L, Dominguez D, Long A, Wang GX, Ma RQ, Li HB, Zhang Y, Fang DY, Sosman J, Zhang B. CD73 expression on effector T cells sustained by TGF-beta facilitates tumor resistance to anti-4-1BB/CD137 therapy. Nature Communications. 2019 Jan;10:15.

Chua KP, Fischer MA, Linder JA. Appropriateness of outpatient antibiotic prescribing among privately insured US patients: ICD-10-CM based cross sectional study. BMJ. 2019 Jan;364:8.

Curry SJ, Krist AH, Owens DK, Barry MJ, Caughey AB, Davidson KW, Doubeni CA, Epling JW, Jr., Kemper AR, Kubik M, Landefeld CS, Mangione CM, Silverstein M, Simon MA, Tseng CW, Wong JB. Ocular Prophylaxis for Gonococcal Ophthalmia Neonatorum: US Preventive Services Task Force Reaffirmation Recommendation Statement. JAMA. 2019 Jan 29;321(4):394-398.

De T, Park CS, Perera MA. Cardiovascular Pharmacogenomics: Does It Matter If You're Black or White? In: Insel PA, ed. Annual Review of Pharmacology and Toxicology, Vol 59. Vol 59. Palo Alto: Annual Reviews; 2019:577-603.

Horwitz S, O'Connor OA, Pro B, et al. Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial.Lancet. 2019 Jan;393(10168):229-240.

Hurcombe JA, Hartley P, Lay AC, Ni L, Bedford JJ, Leader JP, Singh S, Murphy A, Scudamore CL, Marquez E, Barrington AF, Pinto V, Marchetti M, Wong LF, Uney J, Saleem MA, Mathieson PW, Patel S, Walker RJ, Woodgett JR, Quaggin SE, Welsh GI, Coward RJM. Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function. Nature Communications. 2019 Jan;10:17.

James SL, Theadom A, Ellenbogen RG, (including Yano Y). Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.Lancet Neurology. 2019 Jan;18(1):56-87.

Kluender EJ, Hedrick JL, Brown KA, Rao R, Meckes B, Du JS, Moreau LM, Maruyama B, Mirkin CA. Catalyst discovery through megalibraries of nanomaterials. Proceedings of the National Academy of Sciences of the United States of America. 2019 Jan 2;116(1):40-45.

McElroy GS, Chandel NS. Probing mitochondrial metabolism in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2019 Jan 2;116(1):20-22.

Mickle AD, Won SM, Noh KN, Yoon J, Meacham KW, Xue YG, McIlvried LA, Copits BA, Samineni VK, Crawford KE, Kim DH, Srivastava P, Kim BH, Min S, Shiuan Y, Yun Y, Payne MA, Zhang JP, Jang H, Li YH, Lai HH, Huang YG, Park SI, Gereau RW, Rogers JA. A wireless closed-loop system for optogenetic peripheral neuromodulation. Nature. 2019 Jan;565(7739):361.

Nan KW, Wang HL, Ning X, Miller KA, Wei C, Liu YP, Li HB, Xue YG, Xie ZQ, Luan HW, Zhang YH, Huang YG, Rogers JA, Braun PV. Soft Three-Dimensional Microscale Vibratory Platforms for Characterization of Nano-Thin Polymer Films. ACS Nano. 2019 Jan;13(1):449-457.

Nichols E, Szoeke CEI, Vollset SE, (including Yano Y). Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurology. 2019 Jan;18(1):88-106.

Owonikoko TK, Dahlberg SE, Sica GL, Wagner LI, Wade JL, Srkalovic G, Lash BW, Leach JW, Leal TB, Aggarwal C, Ramalingam SS. Randomized Phase II Trial of Cisplatin and Etoposide in Combination With Veliparib or Placebo for Extensive-Stage Small-Cell Lung Cancer: ECOG-ACRIN 2511 Study. Journal of Clinical Oncology. 2019 Jan;37(3):222.

Patel RB, Shah SJ.Drug Targets for Heart Failure with Preserved Ejection Fraction: A Mechanistic Approach and Review of Contemporary Clinical Trials. In: Insel PA, ed. Annual Review of Pharmacology and Toxicology, Vol 59. Vol 59. Palo Alto: Annual Reviews; 2019:41-63.

Rice HC, de Malmazet D, Schreurs A, Frere S, Van Molle I, Volkov AN, Creemers E, Vertkin I, Nys J, Ranaivoson FM, Comoletti D, Savas JN, Remaut H, Balschun D, Wierda KD, Slutsky I, Farrow K, De Strooper B, de Wit J. Secreted amyloid-beta precursor protein functions as a GABA(B)R1a ligand to modulate synaptic transmission. Science. 2019 Jan;363(6423):143.

Saygin C, Matei D, Majeti R, Reizes O, Lathia JD. Targeting Cancer Stemness in the Clinic: From Hype to Hope. Cell Stem Cell. 2019 Jan 3;24(1):25-40.

Shenoy ES, Macy E, Rowe T, Blumenthal KG. Evaluation and Management of Penicillin Allergy A Review. JAMA. 2019 Jan;321(2):188-199.

Swarup V, Hinz FI, Rexach JE, et al (including Grafman J). Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia. Nature Medicine. 2019 Jan;25(1):152.

Treat-Jacobson D, McDermott MM, Bronas UG, Campia U, Collins TC, Criqui MH, Gardner AW, Hiatt WR, Regensteiner JG, Rich K, Amer Heart A. Optimal Exercise Programs for Patients With Peripheral Artery Disease: A Scientific Statement From the American Heart Association. Circulation. 2019 Jan;139(4):E10-E33.

Virani SS, Akeroyd JM, Nambi V, Michos ED, Morris PB, Nasir K, Smith SC, Jr., Stone NJ, Petersen LA, Ballantyne CM. Applicability and Cost Implications for Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors Based on the ODYSSEY Outcomes Trial. Circulation. 2019 Jan 15;139(3):410-412.

Zhao Z, Wang L, Volk AG, Birch NW, Stoltz KL, Bartom ET, Marshall SA, Rendleman EJ, Nestler CM, Shilati J, Schiltz GE, Crispino JD, Shilatifard A.Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia. Genes & Development. 2019 Jan 1;33(1-2):61-74.