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Northwestern University Feinberg School of Medicine
Research

High-Impact-Factor Research 2020

Burton A, Obaid SN, Vazquez-Guardado A, Schmit MB, Stuart T, Cai L, Chen ZY, Kandela I, Haney CR, Waters EA, Cai HJ, Rogers JA, Lu LY, Gutruf P. Wireless, battery-free subdermally implantable photometry systems for chronic recording of neural dynamics. Proceedings of the National Academy of Sciences of the United States of America. 2020;117(6):2835-2845.

Dey N, Kochman ML, Komanduri S, Melson JE, Muthusamy VR. Report from the AGA Center for GI Innovation and Technology's Consensus Conference: Envisioning Next-Generation Paradigms in Colorectal Cancer Screening and Surveillance. Gastroenterology. 2020;158(3):455-460.

Doebele RC, Drilon A, Paz-Ares L, Siena S, Shaw AT, Farago AF, Blakely CM, Seto T, Cho BC, Tosi D, Besse B, Chawla SP, Bazhenova L, Krauss JC, Chae YK, Barve M, Garrido-Laguna I, Liu SV, Conkling P, John T, Fakih M, Sigal D, Loong HH, Buchschacher GL, Garrido P, Nieva J, Steuer C, Overbeck TR, Bowles DW, Fox E, Riehl T, Chow-Maneval E, Simmons B, Cui N, Johnson A, Eng S, Wilson TR, Demetri GD, Trial I. Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1-2 trials. Lancet Oncology. 2020;21(2):271-282.

Drilon A, Siena S, Dziadziuszko R, Barlesi F, Krebs MG, Shaw AT, de Braud F, Rolfo C, Ahn MJ, Wolf J, Seto T, Cho BC, Patel MR, Chiu CH, John T, Goto K, Karapetis CS, Arkenau HT, Kim SW, Ohe Y, Li YC, Chae YK, Chung CH, Otterson GA, Murakami H, Lin CC, Tan DSW, Prenen H, Riehl T, Chow-Maneval E, Simmons B, Cui N, Johnson A, Eng S, Wilson TR, Doebele RC, Trial I. Entrectinib in ROS1 fusion-positive non-small-cell lung cancer: integrated analysis of three phase 1-2 trials. Lancet Oncology. 2020;21(2):261-270.

Ferrer JR, Sinegra AJ, Ivancic D, Yeap XY, Qiu L, Wang JJ, Zhang ZJ, Wertheim JA, Mirkin CA. Structure-Dependent Biodistribution of Liposomal Spherical Nucleic Acids. ACS Nano. 2020;14(2):1682-1693.

Gallego JA, Perich MG, Chowdhury RH, Solla SA, Miller LE. Long-term stability of cortical population dynamics underlying consistent behavior. Nature Neuroscience. 2020;23(2):260.

Greene DJ, Marek S, Gordon EM, Siegel JS, Gratton C, Laumann TO, Gilmore AW, Berg JJ, Nguyen AL, Dierker D, Van AN, Ortega M, Newbold DJ, Hampton JM, Nielsen AN, McDermott KB, Roland JL, Norris SA, Nelson SM, Snyder AZ, Schlaggar BL, Petersen SE, Dosenbach NUF. Integrative and Network-Specific Connectivity of the Basal Ganglia and Thalamus Defined in Individuals. Neuron. 2020;105(4):742.

Jin X, Chandramouli C, Allocco B, Gong E, Lam CSP, Yan LL. Women's Participation in Cardiovascular Clinical Trials From 2010 to 2017. Circulation. 2020;141(7):540-548.

Kosciuk T, Price IR, Zhang X, Zhu C, Johnson KN, Zhang S, Halaby SL, Komaniecki GP, Yang M, DeHart CJ, Thomas PM, Kelleher NL, Fromme JC, Lin H. NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle. Nature Communications. 2020;11(1):1067.

Lioux G, Liu XL, Temino S, Oxendine M, Ayala E, Ortega S, Kelly RG, Oliver G, Torres M. A Second Heart Field-Derived Vasculogenic Niche Contributes to Cardiac Lymphatics. Developmental Cell. 2020;52(3):350.

Liu P, Dodson M, Fang D, Chapman E, Zhang DD. NRF2 negatively regulates primary ciliogenesis and hedgehog signaling. PLoS Biology. 2020;18(2):e3000620.

McLean SA, Ressler K, Koenen KC, et al. (including Elliott JM). The AURORA Study: a longitudinal, multimodal library of brain biology and function after traumatic stress exposure. Molecular Psychiatry. 2020;25(2):283-296.

McMurray JJV, Jackson AM, Lam CSP, Redfield MM, Anand IS, Ge J, Lefkowitz MP, Maggioni AP, Martinez F, Packer M, Pfeffer MA, Pieske B, Rizkala AR, Sabarwal SV, Shah AM, Shah SJ, Shi VC, van Veldhuisen DJ, Zannad F, Zile MR, Cikes M, Goncalvesova E, Katova T, Kosztin A, Lelonek M, Sweitzer N, Vardeny O, Claggett B, Jhund PS, Solomon SD. Effects of Sacubitril-Valsartan Versus Valsartan in Women Compared With Men With Heart Failure and Preserved Ejection Fraction: Insights From PARAGON-HF. Circulation. 2020;141(5):338-351.

Mekhail N, Levy RM, Deer TR, Kapural L, Li SA, Amirdelfan K, Hunter CW, Rosen SM, Costandi SJ, Falowski SM, Burgher AH, Pope JE, Gilmore CA, Qureshi FA, Staats PS, Scowcroft J, Carlson J, Kim CK, Yang MI, Stauss T, Poree L, Brounstein D, Gorman R, Gmel GE, Hanson E, Karantonis DM, Khurram A, Kiefer D, Leitner A, Mugan D, Obradovic M, Parker J, Single P, Soliday N, Evoke Study G. Long-term safety and efficacy of closed-loop spinal cord stimulation to treat chronic back and leg pain (Evoke): a double-blind, randomised, controlled trial. Lancet Neurology. 2020;19(2):123-134.

Moore KM, Nicholas J, Grossman M, et al. (including Rogalski EJ, Weintraub S, Mesulam MM, Bigio E). Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study. Lancet Neurology. 2020;19(2):145-156.

Moyo MB, Parker JB, Chakravarti D. Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas. Nature Communications. 2020;11(1):1019.

Owens DK, Davidson KW, Krist AH, Barry MJ, Cabana M, Caughey AB, Doubeni CA, Epling JW, Jr., Kubik M, Landefeld CS, Mangione CM, Pbert L, Silverstein M, Simon MA, Tseng CW, Wong JB. Screening for Cognitive Impairment in Older Adults: US Preventive Services Task Force Recommendation Statement. JAMA. 2020;323(8):757-763.

Pokatayev V, Yang K, Tu X, Dobbs N, Wu J, Kalb RG, Yan N. Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP. Nature Immunology. 2020;21(2):158-167.

Reiman EM, Arboleda-Velasquez JF, Quiroz YT, et al. (including Mesulam M, Bigio EH) Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nature Communications. 2020;11(1):11.

Sheng Y, Yu C, Liu Y, Hu C, Ma R, Lu X, Ji P, Chen J, Mizukawa B, Huang Y, Licht JD, Qian Z. FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML. Nature Communications. 2020;11(1):928.

Tarhini AA, Lee SJ, Hodi FS, Rao UNM, Cohen GI, Hamid O, Hutchins LF, Sosman JA, Kluger HM, Eroglu Z, Koon HB, Lawrence DP, Kendra KL, Minor DR, Lee CB, Albertini MR, Flaherty LE, Petrella TM, Streicher H, Sondak VK, Kirkwood JM. Phase III Study of Adjuvant Ipilimumab (3 or 10 mg/kg) Versus High-Dose Interferon Alfa-2b for Resected High-Risk Melanoma: North American Intergroup E1609. Journal of Clinical Oncology. 2020;38(6):567-575.

Wani S, Williams JL, Komanduri S, Muthusamy VR, Shaheen NJ. Time Trends in Adherence to Surveillance Intervals and Biopsy Protocol Among Patients With Barrett's Esophagus. Gastroenterology. 2020;158(3):770-772.e772.

Wilkinson S, Harmon SA, Terrigino NT, Karzai F, Pinto PA, Madan RA, VanderWeele DJ, Lake R, Atway R, Bright JR, Carrabba NV, Trostel SY, Lis RT, Chun G, Gulley JL, Merino MJ, Choyke PL, Ye HH, Dahut WL, Turkbey B, Sowalsky AG. A case report of multiple primary prostate tumors with differential drug sensitivity. Nature Communications. 2020;11(1):8.

Xia S, Du X, Guo L, Du J, Arnott C, Lam CSP, Huffman MD, Arima H, Yuan Y, Zheng Y, Wu S, Guang X, Zhou X, Lin H, Cheng X, Anderson CS, Dong J, Ma C. Sex Differences in Primary and Secondary Prevention of Cardiovascular Disease in China. Circulation. 2020;141(7):530-539.

Yao MJ, Ventura PB, Jiang Y, Rodriguez FJ, Wang LX, Perry JSA, Yang YB, Wahl K, Crittenden RB, Bennett ML, Qi L, Gong CC, Li XN, Barres B, Bender TP, Ravichandran KS, Janes KA, Eberhart CG, Zong H. Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth. Cell. 2020;180(3):502.

Yoon S, Parnell E, Kasherman M, Forrest MP, Myczek K, Premarathne S, Vega MCS, Piper M, Burne THJ, Jolly LA, Wood SA, Penzes P. Usp9X Controls Ankyrin-Repeat Domain Protein Homeostasis during Dendritic Spine Development. Neuron. 2020;105(3):506.

Bachta KER, Allen JP, Cheung BH, Chiu CH, Hauser AR. Systemic infection facilitates transmission of Pseudomonas aeruginosa in mice. Nature Communications. 2020;11(1):543.

Del Dotto V, Ullah F, Di Meo I, Magini P, Gusic M, Maresca A, Caporali L, Palombo F, Tagliavini F, Baugh EH, Macao B, Szilagyi Z, Peron C, Gustafson MA, Khan K, La Morgia C, Barboni P, Carbonelli M, Valentino ML, Liguori R, Shashi V, Sullivan J, Nagaraj S, El-Dairi M, Iannaccone A, Cutcutache I, Bertini E, Carrozzo R, Emma F, Diomedi-Camassei F, Zanna C, Armstrong M, Page M, Stong N, Boesch S, Kopajtich R, Wortmann S, Sperl W, Davis EE, Copeland WC, Seri M, Falkenberg M, Prokisch H, Katsanis N, Tiranti V, Pippucci T, Carelli V. SSBP1 mutations cause mtDNA depletion underlying a complex optic atrophy disorder. Journal of Clinical Investigation. 2020;130(1):108-125.

Ding J, Davis-Plourde KL, Sedaghat S, Tully PJ, Wang W, Phillips C, Pase MP, Himali JJ, Gwen Windham B, Griswold M, Gottesman R, Mosley TH, White L, Guethnason V, Debette S, Beiser AS, Seshadri S, Ikram MA, Meirelles O, Tzourio C, Launer LJ. Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies. Lancet Neurology. 2020;19(1):61-70.

Gourh P, Safran SA, Alexander T, Boyden SE, Morgan ND, Shah AA, Mayes MD, Doumatey A, Bentley AR, Shriner D, Domsic RT, Medsger TA, Ramos PS, Silver RM, Steen VD, Varga J, Hsu V, Saketkoo LA, Schiopu E, Khanna D, Gordon JK, Kron B, Criswell LA, Gladue H, Derk CT, Bernstein EJ, Bridges SL, Shanmugam VK, Kolstad KD, Chung L, Kafaja S, Jan R, Trojanowski M, Goldberg A, Korman BD, Steinbach PJ, Chandrasekharappa SC, Mullikin JC, Adeyemo A, Rotimi C, Wigley FM, Kastner DL, Boin F, Remmers EF. HLA and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry. Proceedings of the National Academy of Sciences of the United States of America. 2020;117(1):552-562.

Heravi AS, Etzkorn LH, Urbanek JK, Crainiceanu CM, Punjabi NM, Ashikaga H, Brown TT, Budoff MJ, D'Souza G, Magnani JW, Palella FJ, Jr., Berger RD, Wu KC, Post WS. HIV Infection Is Associated With Variability in Ventricular Repolarization: The Multicenter AIDS Cohort Study (MACS). Circulation. 2020;141(3):176-187.

Huang ZYN, Cole LE, Callmann CE, Wang SY, Mirkin CA. Sequence Multiplicity within Spherical Nucleic Acids. ACS Nano. 2020;14(1):1084-1092.

Klion AD, Ackerman SJ, Bochner BS. Contributions of Eosinophils to Human Health and Disease. Annual Review of Pathology. 2020;15:179-209.

Lafay-Cousin L, Bouffet E, Strother D, Rudneva V, Hawkins C, Eberhart C, Horbinski C, Heier L, Souweidane M, Williams-Hughes C, Onar-Thomas A, Billups CA, Fouladi M, Northcott P, Robinson G, Gajjar A. Phase II Study of Nonmetastatic Desmoplastic Medulloblastoma in Children Younger Than 4 Years of Age: A Report of the Children's Oncology Group (ACNS1221).Journal of Clinical Oncology. 2020;38(3):223.

Martinez-Reyes I, Chandel NS.Mitochondrial TCA cycle metabolites control physiology and disease. Nature Communications. 2020;11(1):102.

MacGowan RJ, Chavez PR, Borkowf CB, Owen SM, Purcell DW, Mermin JH, Sullivan PS, Branson BM, Chiasson MA, Ethridge S, Freeman A, Granade T, Gravens L, Higa D, Hirshfield S, Johnson W, Masciotra S, McNaghten AD, Mullins M, Mustanski B, Raiford J, Sharma A, Sullivan V, Teplinskiy I, Wesolowski L, e SSG. Effect of Internet-Distributed HIV Self-tests on HIV Diagnosis and Behavioral Outcomes in Men Who Have Sex With Men A Randomized Clinical Trial. JAMA Internal Medicine. 2020;180(1):117-125.

McKinney SM, Sieniek M, Godbole V, Godwin J, Antropova N, Ashrafian H, Back T, Chesus M, Corrado GC, Darzi A, Etemadi M, Garcia-Vicente F, Gilbert FJ, Halling-Brown M, Hassabis D, Jansen S, Karthikesalingam A, Kelly CJ, King D, Ledsam JR, Melnick D, Mostofi H, Peng L, Reicher JJ, Romera-Paredes B, Sidebottom R, Suleyman M, Tse D, Young KC, De Fauw J, Shetty S. International evaluation of an AI system for breast cancer screening. Nature. 2020;577(7788):89.

Morris AB, Farley CR, Pinelli DF, Adams LE, Cragg MS, Boss JM, Scharer CD, Fribourg M, Cravedi P, Heeger PS, Ford ML. Signaling through the Inhibitory Fc Receptor Fc gamma RIIB Induces CD8(+) T Cell Apoptosis to Limit T Cell Immunity. Immunity. 2020;52(1):136.

Navarro-Munoz JC, Selem-Mojica N, Mullowney MW, Kautsar SA, Tryon JH, Parkinson EI, De Los Santos ELC, Yeong M, Cruz-Morales P, Abubucker S, Roeters A, Lokhorst W, Fernandez-Guerra A, Cappelini LTD, Goering AW, Thomson RJ, Metcalf WW, Kelleher NL, Barona-Gomez F, Medema MH. A computational framework to explore large-scale biosynthetic diversity. Nature Chemical Biology. 2020;16(1):60.

Paulin LM, Gassett AJ, Alexis NE, et al. (including Anderson WH). Association of Long-term Ambient Ozone Exposure With Respiratory Morbidity in Smokers. JAMA Internal Medicine. 2020;180(1):106-115.

Rivara FP, Tennyson R, Mills B, Browd SR, Emery CA, Gioia G, Giza CC, Herring S, Janz KF, LaBella C, McLeod TV, Meehan W, Patricios J, Rivara FP, Herring S, Browd SR, Gioia G, Giza CC, Cook L, Pacchia N, Keenan H, Cullum M, Four Corners Youth C. Consensus Statement on Sports-Related Concussions in Youth Sports Using a Modified Delphi Approach. JAMA Pediatrics. 2020;174(1):79-85.

Schisterman EF, Sjaarda LA, Clemons T, Carrell DT, Perkins NJ, Johnstone E, Lamb D, Chaney K, Van Voorhis BJ, Ryan G, Summers K, Hotaling J, Robins J, Mills JL, Mendola P, Chen Z, DeVilbiss EA, Peterson CM, Mumford SL. Effect of Folic Acid and Zinc Supplementation in Men on Semen Quality and Live Birth Among Couples Undergoing Infertility Treatment A Randomized Clinical Trial. JAMA-Journal of the American Medical Association. 2020;323(1):35-48.

Schlaff WD, Ackerman RT, Al-Hendy A, Archer DF, Barnhart KT, Bradley LD, Carr BR, Feinberg EC, Hurtado SM, Kim J, Liu R, Mabey RG, Owens CD, Poindexter A, Puscheck EE, Rodriguez-Ginorio H, Simon JA, Soliman AM, Stewart EA, Watts NB, Muneyyirci-Delale O. Elagolix for Heavy Menstrual Bleeding in Women with Uterine Fibroids. New England Journal of Medicine. 2020;382(4):328-340.

Simuni T, Uribe L, Cho HR, et al. (including Williams K). Clinical and dopamine transporter imaging characteristics of non-manifest LRRK2 and GBA mutation carriers in the Parkinson's Progression Markers Initiative (PPMI): a cross-sectional study. Lancet Neurology. 2020;19(1):71-80.

Wang F, Schoenbaum G, Kahnt T.Interactions between human orbitofrontal cortex and hippocampus support model-based inference. PLoS Biology. 2020;18(1):e3000578.

Williams JB, Li S, Higgs EF, Cabanov A, Wang X, Huang H, Gajewski TF. Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-gamma-signaling mutant cancer cells. Nature Communications. 2020;11(1):602.

Xu H, Dzhashiashvili Y, Shah A, Kunjamma RB, Weng YL, Elbaz B, Fei QL, Jones JS, Li YI, Zhuang XX, Ming GL, He C, Popko B. m(6)A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination. Neuron. 2020;105(2):293.

Yamankurt G, Stawicki RJ, Posadas DM, Nguyen JQ, Carthew RW, Mirkin CA. The effector mechanism of siRNA spherical nucleic acids. Proceedings of the National Academy of Sciences of the United States of America. 2020;117(3):1312-1320.

Yan TX, Liang JJ, Gao J, et al. (including Mesulam MM, Mesulam MM, Rogalski E, Lipowski K, Weintraub S, Bonakdarpour B, Kerwin D, Wu CK, Johnson N). FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease. Nature Communications. 2020;11(1):16.