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Northwestern University Feinberg School of Medicine
Research

High-Impact-Factor Research 2021

Allen PB, Savas H, Evens AM, Advani RH, Palmer B, Pro B, Karmali R, Mou E, Bearden J, Dillehay G, Bayer RA, Eisner RM, Chmiel JS, O'Shea K, Gordon LI, Winter JN. Pembrolizumab followed by AVD in untreated early unfavorable and advanced-stage classical Hodgkin lymphoma. Blood. 2021;137(10):1318-1326.

Avila R, Li CH, Xue YG, Rogers JA, Huang YG. Modeling programmable drug delivery in bioelectronics with electrochemical actuation.Proceedings of the National Academy of Sciences of the United States of America. 2021;118(11):8.

Brodie-Kommit J, Clark BS, Shi Q, Shiau F, Kim DW, Langel J, Sheely C, Ruzycki PA, Fries M, Javed A, Cayouette M, Schmidt T, Badea T, Glaser T, Zhao H, Singer J, Blackshaw S, Hattar S. Atoh7-independent specification of retinal ganglion cell identity. Science Advances. 2021;7(11):18.

Chia R, Sabir MS, Bandres-Ciga S, et al. (including Flanagan ME, Mao Q, Bigio EH). Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. Nature Genetics. 2021;53(3):294-303.

Chuzi S, Kuang F, Khan SS. Hidden in Plain Sight: An Elusive Cause of Cardiogenic Shock. Circulation. 2021;143(9):959-964.

DeBerge M, Glinton K, Subramanian M, Wilsbacher LD, Rothlin CV, Tabas I, Thorp EB. Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction. Journal of Clinical Investigation. 2021;131(6).

Feldstein LR, Tenforde MW, Friedman KG, Newhams M, Rose EB, Dapul H, Soma VL, Maddux AB, Mourani PM, Bowens C, Maamari M, Hall MW, Riggs BJ, Giuliano JS, Singh AR, Li S, Kong M, Schuster JE, McLaughlin GE, Schwartz SP, Walker TC, Loftis LL, Hobbs CV, Halasa NB, Doymaz S, Babbitt CJ, Hume JR, Gertz SJ, Irby K, Clouser KN, Cvijanovich NZ, Bradford TT, Smith LS, Heidemann SM, Zackai SP, Wellnitz K, Nofziger RA, Horwitz SM, Carroll RW, Rowan CM, Tarquinio KM, Mack EH, Fitzgerald JC, Coates BM, Jackson AM, Young CC, Son MBF, Patel MM, Newburger JW, Randolph AG, Overcoming Covid I. Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19. JAMA-Journal of the American Medical Association. 2021;325(11):1074-1087.

Gacita AM, Fullenkamp DE, Ohiri J, Pottinger T, Puckelwartz MJ, Nobrega MA, McNally EM.Genetic Variation in Enhancers Modifies Cardiomyopathy Gene Expression and Progression. Circulation. 2021;143(13):1302-1316.

Gao XY, Xia X, Li FY, Zhang ML, Zhou HK, Wu XJ, Zhong J, Zhao Z, Zhao K, Liu DW, Xiao FZ, Xu Q, Jiang T, Li B, Cheng SY, Zhang N. Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR-STAT3 signalling. Nature Cell Biology. 2021;23(3):278.

Gharzai LA, Jiang R, Wallington D, Jones G, Birer S, Jairath N, Jaworski EM, McFarlane MR, Mahal BA, Nguyen PL, Sandler H, Morgan TM, Reichert ZR, Alumkal JJ, Mehra R, Kishan AU, Fizazi K, Halabi S, Schaeffer EM, Feng FY, Elliott D, Dess RT, Jackson WC, Schipper MJ, Spratt DE. Intermediate clinical endpoints for surrogacy in localised prostate cancer: an aggregate meta-analysis. Lancet Oncology. 2021;22(3):402-410.

Gunderson EP, Sun B, Catov JM, Carnethon M, Lewis CE, Allen NB, Sidney S, Wellons M, Rana JS, Hou L, Carr JJ. Gestational Diabetes History and Glucose Tolerance After Pregnancy Associated With Coronary Artery Calcium in Women During Midlife: The CARDIA Study.Circulation. 2021;143(10):974-987.

Huang T, Yang Y, Song X, Wan X, Wu B, Sastry N, Horbinski CM, Zeng C, Tiek D, Goenka A, Liu F, Brennan CW, Kessler JA, Stupp R, Nakano I, Sulman EP, Nishikawa R, James CD, Zhang W, Xu W, Hu B, Cheng SY. PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells. Molecular Cell. 2021;81(6):1276-1291.e1279.

Kalil AC, Patterson TF, Mehta AK, Tomashek KM, Wolfe CR, Ghazaryan V, Marconi VC, Ruiz-Palacios GM, Hsieh L, Kline S, Tapson V, Iovine NM, Jain MK, Sweeney DA, El Sahly HM, Branche AR, Pineda JR, Lye DC, Sandkovsky U, Luetkemeyer AF, Cohen SH, Finberg RW, Jackson PEH, Taiwo B, Paules CI, Arguinchona H, Erdmann N, Ahuja N, Frank M, Oh M, Kim ES, Tan SY, Mularski RA, Nielsen H, Ponce PO, Taylor BS, Larson LA, Rouphael NG, Saklawi Y, Cantos VD, Ko ER, Engemann JJ, Amin AN, Watanabe M, Billings J, Elie MC, Davey RT, Burgess TH, Ferreira J, Green M, Makowski M, Cardoso A, de Bono S, Bonnett T, Proschan M, Deye GA, Dempsey W, Nayak SU, Dodd LE, Beigel JH, Members A-SG. Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19. New England Journal of Medicine. 2021;384(9):795-807.

Kim HR, Rajagopal L, Meltzer HY, Martina M. Depolarizing GABA(A) current in the prefrontal cortex is linked with cognitive impairment in a mouse model relevant for schizophrenia. Science Advances. 2021;7(14).

Kim S, Wong YC, Gao F, Krainc D. Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson's disease. Nature Communications. 2021;12(1):1807.

Kumthekar P, Ko CH, Paunesku T, Dixit K, Sonabend AM, Bloch O, Tate M, Schwartz M, Zuckerman L, Lezon R, Lukas RV, Jovanovic B, McCortney K, Colman H, Chen S, Lai B, Antipova O, Deng JJ, Li LX, Tommasini-Ghelfi S, Hurley LA, Unruh D, Sharma NV, Kandpal M, Kouri FM, Davuluri RV, Brat DJ, Muzzio M, Glass M, Vijayakumar V, Heidel J, Giles FJ, Adams AK, James CD, Woloschak GE, Horbinski C, Stegh AH. A first-in-human phase 0 clinical study of RNA interference-based spherical nucleic acids in patients with recurrent glioblastoma. Science Translational Medicine. 2021;13(584):14.

Lahrouchi N, Postma AV, Salazar CM, De Laughter DM, Tjong F, Piherova L, Bowling FZ, Zimmerman D, Lodder EM, Ta-Shma A, Perles Z, Beekman L, Ilgun A, Gunst Q, Hababa M, Skoric-Milosavljevic D, Stranecky V, Tomek V, de Knijff P, de Leeuw R, Robinson JY, Burn SC, Mustafa H, Ambrose M, Moss T, Jacober J, Niyazov DM, Wolf B, Kim KH, Cherny S, Rousounides A, Aristidou-Kallika A, Tanteles G, Ange-Line B, Denomme-Pichon AS, Francannet C, Ortiz D, Haak MC, Ten Harkel ADJ, Manten GTR, Dutman AC, Bouman K, Magliozzi M, Radio FC, Santen GWE, Herkert JC, Brown HA, Elpeleg O, van den Hoff MJB, Mulder B, Airola MV, Kmoch S, Barnett JV, Clur SA, Frohman MA, Bezzina CR. Biallelic loss-of-function variants in PLD1 cause congenital right-sided cardiac valve defects and neonatal cardiomyopathy. Journal of Clinical Investigation. 2021;131(5):13.

Li Q, Kolluru VSC, Rahn MS, Schwenker E, Li S, Hennig RG, Darancet P, Chan MKY, Hersam MC. Synthesis of borophane polymorphs through hydrogenation of borophene. Science. 2021;371(6534):1143-1148.

List AF, Sun Z, Verma A, Bennett JM, Komrokji RS, McGraw K, Maciejewski J, Altman JK, Cheema PS, Claxton DF, Luger SM, Mattison RJ, Wassenaar TR, Artz AS, Schiffer CA, Litzow MR, Tallman MS. Lenalidomide-Epoetin Alfa Versus Lenalidomide Monotherapy in Myelodysplastic Syndromes Refractory to Recombinant Erythropoietin. Journal of Clinical Oncology. 2021;39(9):1001-1009.

McGrath K, Agarwal S, Tonelli M, Dergai M, Gaeta AL, Shum AK, Lacoste J, Zhang Y, Wen W, Chung D, Wiersum G, Shevade A, Zaichick S, van Rossum DB, Shuvalova L, Savas JN, Kuchin S, Taipale M, Caldwell KA, Caldwell GA, Fasshauer D, Caraveo G.A conformational switch driven by phosphorylation regulates the activity of the evolutionarily conserved SNARE Ykt6. Proceedings of the National Academy of Sciences of the United States of America. 2021;118(12).

Park Y, Franz CK, Ryu H, Luan HW, Cotton KY, Kim JU, Chung TS, Zhao SW, Vazquez-Guardado A, Yang DS, Li K, Avila R, Phillips JK, Quezada MJ, Jang H, Kwak SS, Won SM, Kwon K, Jeong H, Bandodkar AJ, Han MD, Zhao HB, Osher GR, Wang HL, Lee K, Zhang YH, Huang YG, Finan JD, Rogers JA.Three-dimensional, multifunctional neural interfaces for cortical spheroids and engineered assembloids. Science Advances. 2021;7(12):11.

Patel RB, Ter Maaten JM, Ferreira JP, McCausland FR, Shah SJ, Rossignol P, Solomon SD, Vaduganathan M, Packer M, Thompson A, Stockbridge N, Zannad F. Challenges of Cardio-Kidney Composite Outcomes in Large-Scale Clinical Trials.Circulation. 2021;143(9):949-958.

Pituch KC, Zannikou M, Ilut L, Xiao T, Chastkofsky M, Sukhanova M, Bertolino N, Procissi D, Amidei C, Horbinski CM, Aboody KS, James CD, Lesniak MS, Balyasnikova IV. Neural stem cells secreting bispecific T cell engager to induce selective antiglioma activity. Proceedings of the National Academy of Sciences of the United States of America. 2021;118(9):11.

Ray TR, Ivanovic M, Curtis PM, Franklin D, Guventurk K, Jeang WJ, Chafetz J, Gaertner H, Young G, Rebollo S, Model JB, Lee SP, Ciraldo J, Reeder JT, Hourlier-Fargette A, Bandodkar AJ, Choi J, Aranyosi AJ, Ghaffari R, McColley SA, Haymond S, Rogers JA. Soft, skin-interfaced sweat stickers for cystic fibrosis diagnosis and management. Science Translational Medicine. 2021;13(587).

Schachner LF, Jooss K, Morgan MA, Piunti A, Meiners MJ, Kafader JO, Lee AS, Iwanaszko M, Cheek MA, Burg JM, Howard SA, Keogh MC, Shilatifard A, Kelleher NL. Decoding the protein composition of whole nucleosomes with Nuc-MS. Nature Methods. 2021;18(3):303.

Simuni T, Fiske B, Merchant K, Coffey CS, Klingner E, Caspell-Garcia C, Lafontant DE, Matthews H, Wyse RK, Brundin P, Simon DK, Schwarzschild M, Weiner D, Adams J, Venuto C, Dawson TM, Baker L, Kostrzebski M, Ward T, Rafaloff G, Parkinson Study G. Efficacy of Nilotinib in Patients With Moderately Advanced Parkinson Disease A Randomized Clinical Trial. JAMA Neurology. 2021;78(3):312-320.

Sinnige T, Meisl G, Michaels TCT, Vendruscolo M, Knowles TPJ, Morimoto RI. Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in C. elegans. Proceedings of the National Academy of Sciences of the United States of America. 2021;118(11):7.

Sula A, Hollingworth D, Ng LCT, Larmore M, DeCaen PG, Wallace BA. A tamoxifen receptor within a voltage-gated sodium channel.Molecular Cell. 2021;81(6):1160-1169.e1165.

Tromp J, Paniagua SMA, Lau ES, Allen NB, Blaha MJ, Gansevoort RT, Hillege HL, Lee DE, Levy D, Ramachandran VS, van der Harst P, van Gilst WH, Larson MG, Shah SJ, de Boer RA, Lam CSP, Ho JE. Age dependent associations of risk factors with heart failure: pooled population based cohort study. BMJ-British Medical Journal. 2021;372:9.

Wang Y, Li M, Chang JK, Aurelio D, Li W, Kim BJ, Kim JH, Liscidini M, Rogers JA, Omenetto FG. Light-activated shape morphing and light-tracking materials using biopolymer-based programmable photonic nanostructures.Nature Communications. 2021;12(1):9.

Weng X, Kumar A, Cao L, He Y, Morgun E, Visvabharathy L, Zhao J, Sena LA, Weinberg SE, Chandel NS, Wang CR.Mitochondrial metabolism is essential for invariant natural killer T cell development and function.Proceedings of the National Academy of Sciences of the United States of America. 2021;118(13).

Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF, Grp SS. Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine. 2021;384(11):989-1002.

Yang B, Sanches-Padilla J, Kondapalli J, Morison SL, Delpire E, Awatramani R, Surmeier DJ.Locus coeruleus anchors a trisynaptic circuit controlling fear-induced suppression of feeding. Neuron. 2021;109(5):823-838.e826.

 

Bassetti M, Echols R, Matsunaga Y, Ariyasu M, Doi Y, Ferrer R, Lodise TP, Naas T, Niki Y, Paterson DL, Portsmouth S, Torre-Cisneros J, Toyoizumi K, Wunderink RG, Nagata TD. Efficacy and safety of cefiderocol or best available therapy for the treatment of serious infections caused by carbapenem-resistant Gram-negative bacteria (CREDIBLE-CR): a randomised, open-label, multicentre, pathogen-focused, descriptive, phase 3 trial. Lancet Infectious Diseases. 2021;21(2):226-240.

Blum TR, Liu H, Packer MS, Xiong X, Lee PG, Zhang S, Richter M, Minasov G, Satchell KJF, Dong M, Liu DR. Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity. Science. 2021;371(6531):803-810.

Buss EW, Corbett NJ, Roberts JG, Ybarra N, Musial TF, Simkin D, Molina-Campos E, Oh KJ, Nielsen LL, Ayala GD, Mullen SA, Farooqi AK, D'Souza GX, Hill CL, Bean LA, Rogalsky AE, Russo ML, Curlik DM, Antion MD, Weiss C, Chetkovich DM, Oh MM, Disterhoft JF, Nicholson DA. Cognitive aging is associated with redistribution of synaptic weights in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. 2021;118(8).

Chen C, Gu Y, Philippe J, Zhang P, Bachman H, Zhang J, Mai J, Rufo J, Rawls JF, Davis EE, Katsanis N, Huang TJ. Acoustofluidic rotational tweezing enables high-speed contactless morphological phenotyping of zebrafish larvae. Nature Communications. 2021;12(1):1118.

Dorrier CE, Aran D, Haenelt EA, Sheehy RN, Hoi KK, Pintaric L, Chen YN, Lizama CO, Cautivo KM, Weiner GA, Popko B, Fancy SPJ, Arnold TD, Daneman R. CNS fibroblasts form a fibrotic scar in response to immune cell infiltration. Nature Neuroscience. 2021;24(2):234.

Fang Y, Prominski A, Rotenberg MY, Meng LY, Ledesma HA, Lv YY, Yue JP, Schaumann E, Jeong J, Yamamoto N, Jiang YW, Elbaz B, Wei W, Tian BZ. Micelle-enabled self-assembly of porous and monolithic carbon membranes for bioelectronic interfaces. Nature Nanotechnology. 2021;16(2):206.

Franklin D, Ueltschi T, Carlini A, Yao S, Reeder J, Richards B, Van Duyne RP, Rogers JA. Bioresorbable Microdroplet Lasers as Injectable Systems for Transient Thermal Sensing and Modulation. ACS Nano. 2021;15(2):2327-2339.

Gottlieb RL, Nirula A, Chen P, Boscia J, Heller B, Morris J, Huhn G, Cardona J, Mocherla B, Stosor V, Shawa I, Kumar P, Adams AC, Van Naarden J, Custer KL, Durante M, Oakley G, Schade AE, Holzer TR, Ebert PJ, Higgs RE, Kallewaard NL, Sabo J, Patel DR, Klekotka P, Shen L, Skovronsky DM. Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19 A Randomized Clinical Trial. JAMA-Journal of the American Medical Association. 2021;325(7):632-644.

Grant RA, Morales-Nebreda L, Markov NS, Swaminathan S, Querrey M, Guzman ER, Abbott DA, Donnelly HK, Donayre A, Goldberg IA, Klug ZM, Borkowski N, Lu ZY, Kihshen H, Politanska Y, Sichizya L, Kang MJ, Shilatifard A, Qi C, Lomasney JW, Argento AC, Kruser JM, Malsin ES, Pickens CO, Smith SB, Walter JM, Pawlowski AE, Schneider D, Nannapaneni P, Abdala-Valencia H, Bharat A, Gottardi CJ, Budinger GRS, Misharin AV, Singer BD, Wunderink RG, Investigators NSS. Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia. Nature. 2021;590(7847):27.

Huang KM, Thomas MZ, Magdy T, Eisenmann ED, Uddin ME, DiGiacomo DF, Pan A, Keiser M, Otter M, Xia SH, Li Y, Jin Y, Fu Q, Gibson AA, Bonilla IM, Carnes CA, Corps KN, Coppola V, Smith SA, Addison D, Nies AT, Bundschuh R, Chen TS, Lustberg MB, Wang J, Oswald S, Campbell MJ, Yan PS, Baker SD, Hu SY, Burridge PW, Sparreboom A. Targeting OCT3 attenuates doxorubicin-induced cardiac injury.Proceedings of the National Academy of Sciences of the United States of America. 2021;118(5):9.

Kim YJ, Kong QY, Yamamoto S, Kuramoto K, Huang M, Wang N, Hong JH, Xiao T, Levine B, Qiu XX, Zhao YX, Miller RJ, Dong HX, Meltzer HY, Xu M, He CC. An autophagy-related protein Becn2 regulates cocaine reward behaviors in the dopaminergic system. Science Advances. 2021;7(8):19.


Krist AH, Davidson KW, Mangione CM, Barry MJ, Cabana M, Caughey AB, Donahue K, Doubeni CA, Epling JW, Kubik M, Ogedegbe G, Pbert L, Silverstein M, Simon MA, Tseng CW, Wong JB, Force USPST. Screening for Asymptomatic Carotid Artery Stenosis US Preventive Services Task Force Recommendation Statement. JAMA-Journal of the American Medical Association. 2021;325(5):476-481.

Kwon K, Wang HL, Lim J, Chun KS, Jang H, Yoo I, Wu D, Chen AJ, Gu CG, Lipschultz L, Kim JU, Kim J, Jeong H, Luan HW, Park Y, Su CJ, Ishida Y, Madhvapathy SR, Ikoma A, Kwak JW, Yang S, Banks A, Xu S, Huang YG, Chang JK, Rogers JA. Wireless, soft electronics for rapid, multisensor measurements of hydration levels in healthy and diseased skin. Proceedings of the National Academy of Sciences of the United States of America. 2021;118(5):12.


Lu W, Bai WB, Zhang H, Xu CK, Chiarelli AM, Vazquez-Guardado A, Xie ZQ, Shen HX, Nandoliya K, Zhao HB, Lee K, Wu YX, Franklin D, Avila R, Xu S, Rwei A, Han MD, Kwon K, Deng YJ, Yu XG, Thorp EB, Feng X, Huang YG, Forbess J, Ge ZD, Rogers JA. Wireless, implantable catheter-type oximeter designed for cardiac oxygen saturation. Science Advances. 2021;7(7):14.

Mahadevaraju S, Fear JM, Akeju M, Galletta BJ, Pinheiro M, Avelino CC, Cabral-de-Mello DC, Conlon K, Dell'Orso S, Demere Z, Mansuria K, Mendonça CA, Palacios-Gimenez OM, Ross E, Savery M, Yu K, Smith HE, Sartorelli V, Yang H, Rusan NM, Vibranovski MD, Matunis E, Oliver B. Dynamic sex chromosome expression in Drosophila male germ cells. Nature Communications. 2021;12(1):892.

McQuattie-Pimentel AC, Ren ZY, Joshi N, Watanabe S, Stoeger T, Chi M, Lu ZY, Sichizya L, Aillon RP, Chen CI, Soberanes S, Chen ZY, Reyfman PA, Walter JM, Anekalla KR, Davis JM, Helmin KA, Runyan CE, Abdala-Valencia H, Nam K, Meliton AY, Winter DR, Morimoto RI, Mutlu GM, Bharat A, Perlman H, Gottardi CJ, Ridge KM, Chandel NS, Sznajder JI, Balch WE, Singer BD, Misharin AV, Budinger GRS. The lung microenvironment shapes a dysfunctiona response of alveolar macrophages in aging. Journal of Clinical Investigation. 2021;131(4):21.

Miska J, Rashidi A, Lee-Chang C, Gao P, Lopez-Rosas A, Zhang P, Burga R, Castro B, Xiao T, Han Y, Hou D, Sampat S, Cordero A, Stoolman JS, Horbinski CM, Burns M, Reshetnyak YK, Chandel NS, Lesniak MS.Polyamines drive myeloid cell survival by buffering intracellular pH to promote immunosuppression in glioblastoma. Science Advances. 2021;7(8):15.

Muldoon JJ, Kandula V, Hong M, Donahue PS, Boucher JD, Bagheri N, Leonard JN.Model-guided design of mammalian genetic programs.Science Advances. 2021;7(8):12.

 

Perak AM, Lancki N, Kuang A, Labarthe DR, Allen NB, Shah SH, Lowe LP, Grobman WA, Lawrence JM, Lloyd-Jones DM, Lowe WL, Scholtens DM, Hapo Follow-Up Study Cooperative R. Associations of Maternal Cardiovascular Health in Pregnancy With Offspring Cardiovascular Health in Early Adolescence. JAMA-Journal of the American Medical Association. 2021;325(7):658-668.

Stark JC, Jaroentomeechai T, Moeller TD, Hershewe JM, Warfel KF, Moricz BS, Martini AM, Dubner RS, Hsu KJ, Stevenson TC, Jones BD, DeLisa MP, Jewett MC. On-demand biomanufacturing of protective conjugate vaccines. Science Advances. 2021;7(6):15.

Tasca A, Helmstädter M, Brislinger MM, Haas M, Mitchell B, Walentek P. Notch signaling induces either apoptosis or cell fate change in multiciliated cells during mucociliary tissue remodeling. Developmental Cell. 2021;56(4):525-539.e526.

Wainger BJ, Macklin EA, Vucic S, McIlduff CE, Paganoni S, Maragakis NJ, Bedlack R, Goyal NA, Rutkove SB, Lange DJ, Rivner MH, Goutman SA, Ladha SS, Mauricio EA, Baloh RH, Simmons Z, Pothier L, Kassis SB, La T, Hall M, Evora A, Klements D, Hurtado A, Pereira JD, Koh J, Celnik PA, Chaudhry V, Gable K, Juel VC, Phielipp N, Marei A, Rosenquist P, Meehan S, Oskarsson B, Lewis RA, Kaur D, Kiskinis E, Woolf CJ, Eggan K, Weiss MD, Berry JD, David WS, Davila-Perez P, Camprodon JA, Pascual-Leone A, Kiernan MC, Shefner JM, Atassi N, Cudkowicz ME. Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis A Randomized Clinical Trial. JAMA Neurology. 2021;78(2):186-196.

Weiner AB, Vidotto T, Liu Y, Mendes AA, Salles DC, Faisal FA, Murali S, McFarlane M, Imada EL, Zhao X, Li Z, Davicioni E, Marchionni L, Chinnaiyan AM, Freedland SJ, Spratt DE, Wu JD, Lotan TL, Schaeffer EM. Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes. Nature Communications. 2021;12(1):935.

Wunderink RG, Matsunaga Y, Ariyasu M, Clevenbergh P, Echols R, Kaye KS, Kollef M, Menon A, Pogue JM, Shorr AF, Timsit JF, Zeitlinger M, Nagata TD. Cefiderocol versus high-dose, extended-infusion meropenem for the treatment of Gram-negative nosocomial pneumonia (APEKS-NP): a randomised, double-blind, phase 3, non-inferiority trial. Lancet Infectious Diseases. 2021;21(2):213-225.

Zheng B, Aoi Y, Shah AP, Iwanaszko M, Das S, Rendleman EJ, Zha D, Khan N, Smith ER, Shilatifard A.Acute perturbation strategies in interrogating RNA polymerase II elongation factor function in gene expression. Genes & Development. 2021;35(3-4):273-285.

Adams D, Polydefkis M, Gonzalez-Duarte A, Wixner J, Kristen AV, Schmidt HH, Berk JL, Lopez IAL, Dispenzieri A, Quan D, Conceicao IM, Slama MS, Gillmore JD, Kyriakides T, Ajroud-Driss S, Waddington-Cruz M, Mezei MM, Plante-Bordeneuve V, Attarian S, Mauricio E, Brannagan TH, Ueda M, Aldinc E, Wang JJ, White MT, Vest J, Berber E, Sweetser MT, Coelho T, Patisiran Global OLESG. Long-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy: 12-month results of an open-label extension study. Lancet Neurology. 2021;20(1):49-59.

Bhansali RS, Rammohan M, Lee P, Laurent AP, Wen Q, Suraneni P, Yip BH, Tsai YC, Jenni S, Bornhauser B, Siret A, Fruit C, Pacheco-Benichou A, Harris E, Besson T, Thompson BJ, Goo YA, Hijiya N, Vilenchik M, Izraeli S, Bourquin JP, Malinge S, Crispino JD. DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3. Journal of Clinical Investigation. 2021;131(1):18.

Bona K, Brazauskas R, He N, Lehmann L, Abdel-Azim H, Ahmed IA, Al-Homsi AS, Aljurf M, Arnold SD, Badawy SM, Battiwalla M, Beattie S, Bhatt NS, Dalal J, Dandoy CE, Diaz MA, Frangoul HA, Freytes CO, Ganguly S, George B, Gomez-Almaguer D, Hahn T, Kamble RT, Knight JM, LeMaistre CF, Law J, Lazarus HM, Majhail NS, Olsson RF, Preussler J, Savani BN, Schears R, Seo S, Sharma A, Srivastava A, Steinberg A, Szwajcer D, Wirk B, Yoshimi A, Khera N, Wood WA, Hashmi S, Duncan CN, Saber W. Neighborhood poverty and pediatric allogeneic hematopoietic cell transplantation outcomes: a CIBMTR analysis. Blood. 2021;137(4):556-568.

Cenik BK, Shilatifard A. COMPASS and SWI/SNF complexes in development and disease. Nature Reviews Genetics. 2021;22(1):38-58.

Chang S, Pierson E, Koh PW, Gerardin J, Redbird B, Grusky D, Leskovec J. Mobility network models of COVID-19 explain inequities and inform reopening. Nature. 2021;589(7840):82-U54.

Chen P, Nirula A, Heller B, Gottlieb RL, Boscia J, Morris J, Huhn G, Cardona J, Mocherla B, Stosor V, Shawa I, Adams AC, Van Naarden J, Custer KL, Shen L, Durante M, Oakley G, Schade AE, Sabo J, Patel DR, Klekotka P, Skovronsky DM. SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19. New England Journal of Medicine. 2021;384(3):229-237.

Chen X, Lloyd SM, Kweon J, Gamalong GM, Bao X.Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration. Nature Communications. 2021;12(1):448.

Conti DV, Darst BF, Moss LC, et al. (including Murphy AB). Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nature Genetics. 2021;53(1):30.

Cooler S, Schwartz GW. An offset ON-OFF receptive field is created by gap junctions between distinct types of retinal ganglion cells. Nature Neuroscience. 2021;24(1):105-115.

Dalal PJ, Sullivan DP, Weber EW, Sacks DB, Gunzer M, Grumbach IM, Brown JH, Muller WA.Spatiotemporal restriction of endothelial cell calcium signaling is required during leukocyte transmigration. Journal of Experimental Medicine. 2021;218(1):18.

Deland K, Starr BF, Mercer JS, Byemerwa J, Crabtree DM, Williams NT, Luo LX, Ma Y, Chen M, Becher OJ, Kirsch DG. Tumor genotype dictates radiosensitization after Atm deletion in primary brainstem glioma models. Journal of Clinical Investigation. 2021;131(1):12.

DiNardo CD, Stein AS, Stein EM, Fathi AT, Frankfurt O, Schuh AC, Döhner H, Martinelli G, Patel PA, Raffoux E, Tan P, Zeidan AM, de Botton S, Kantarjian HM, Stone RM, Frattini MG, Lersch F, Gong J, Gianolio DA, Zhang V, Franovic A, Fan B, Goldwasser M, Daigle S, Choe S, Wu B, Winkler T, Vyas P. Mutant Isocitrate Dehydrogenase 1 Inhibitor Ivosidenib in Combination With Azacitidine for Newly Diagnosed Acute Myeloid Leukemia. Journal of Clinical Oncology. 2021;39(1):57-65.

Evens AM, Danilov A, Jagadeesh D, Sperling A, Kim SH, Vaca R, Wei C, Rector D, Sundaram S, Reddy N, Lin Y, Farooq U, D'Angelo C, Bond DA, Berg S, Churnetski MC, Godara A, Khan N, Choi YK, Yazdy M, Rabinovich E, Varma G, Karmali R, Mian A, Savani M, Burkart M, Martin P, Ren A, Chauhan A, Diefenbach C, Straker-Edwards A, Klein AK, Blum KA, Boughan KM, Smith SE, Haverkos BM, Orellana-Noia VM, Kenkre VP, Zayac A, Ramdial J, Maliske SM, Epperla N, Venugopal P, Feldman TA, Smith SD, Stadnik A, David KA, Naik S, Lossos IS, Lunning MA, Caimi P, Kamdar M, Palmisiano N, Bachanova V, Portell CA, Phillips T, Olszewski AJ, Alderuccio JP. Burkitt lymphoma in the modern era: real-world outcomes and prognostication across 30 US cancer centers. Blood. 2021;137(3):374-386.

Fang CL, Philips SJ, Wu XX, Chen K, Shi J, Shen LQ, Xu JC, Feng Y, O'Halloran TV, Zhang Y. CueR activates transcription through a DNA distortion mechanism. Nature Chemical Biology. 2021;17(1):24.

Farkas M, Hashimoto H, Bi Y, Davuluri RV, Resnick-Silverman L, Manfredi JJ, Debler EW, McMahon SB. Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates. Nature Communications. 2021;12(1):484.

Gao DX, Ciancanelli MJ, Zhang P, Harschnitz O, Bondet V, Hasek M, Chen J, Mu X, Itan Y, Cobat A, Sancho-Shimizu V, Bigio B, Lorenzo L, Ciceri G, McAlpine J, Anguiano E, Jouanguy E, Chaussabel D, Meyts I, Diamond MS, Abel L, Hur S, Smith GA, Notarangelo L, Duffy D, Studer L, Casanova JL, Zhang SY. TLR3 controls constitutive IFN-beta antiviral immunity in human fibroblasts and cortical neurons. Journal of Clinical Investigation. 2021;131(1):17.

Gupta S, Wang W, Hayek SS, Chan LL, Mathews KS, Melamed ML, Brenner SK, Leonberg-Yoo A, Schenck EJ, Radbel J, Reiser J, Bansal A, Srivastava A, Zhou Y, Finkel D, Green A, Mallappallil M, Faugno AJ, Zhang JJ, Velez JCQ, Shaefi S, Parikh CR, Charytan DM, Athavale AM, Friedman AN, Redfern RE, Short SAP, Correa S, Pokharel KK, Admon AJ, Donnelly JP, Gershengorn HB, Douin DJ, Semler MW, Hernan MA, Leaf DE, Investigators S-C. Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19. JAMA Internal Medicine. 2021;181(1):41-51.

Huang QQ, Doyle R, Chen SY, Sheng QC, Misharin AV, Mao QW, Winter DR, Pope RM. Critical role of synovial tissue-resident macrophage niche in joint homeostasis and suppression of chronic inflammation. Science Advances. 2021;7(2):15.

Huffman MD, Patel A. Polypills - A Central Strategy for Improving Cardiovascular Health. New England Journal of Medicine. 2021;384(3):288-289.

Johnston SRD, Hegg R, Im SA, Park IH, Burdaeva O, Kurteva G, Press MF, Tjulandin S, Iwata H, Simon SD, Kenny S, Sarp S, Izquierdo MA, Williams LS, Gradishar WJ.Phase III, Randomized Study of Dual Human Epidermal Growth Factor Receptor 2 (HER2) Blockade With Lapatinib Plus Trastuzumab in Combination With an Aromatase Inhibitor in Postmenopausal Women With HER2-Positive, Hormone Receptor-Positive Metastatic Breast Cancer: Updated Results of ALTERNATIVE. Journal of Clinical Oncology. 2021;39(1):79-89.

Karigo T, Kennedy A, Yang B, Liu MY, Tai D, Wahle IA, Anderson DJ. Distinct hypothalamic control of same- and opposite-sex mounting behaviour in mice. Nature. 2021;589(7841):258.

Krist AH, Davidson KW, Mangione CM, Barry MJ, Cabana M, Caughey AB, Donahue K, Doubeni CA, Epling JW, Jr., Kubik M, Ogedegbe G, Pbert L, Silverstein M, Simon MA, Tseng CW, Wong JB. Interventions for Tobacco Smoking Cessation in Adults, Including Pregnant Persons: US Preventive Services Task Force Recommendation Statement. JAMA-Journal of the American Medical Association. 2021;325(3):265-279.

Kunkle BW, Schmidt M, Klein HU, et al. (including Vassar R). Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. JAMA Neurology. 2021;78(1):102-113.

Lagou V, Mägi R, Hottenga JJ, Grallert H, et al. (including Rasmussen-Torvik LJ). Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability. Nature Communications. 2021;12(1):24.

Lee-Chang C, Miska J, Hou D, Rashidi A, Zhang P, Burga RA, Jusue-Torres I, Xiao T, Arrieta VA, Zhang DY, Lopez-Rosas A, Han Y, Sonabend AM, Horbinski CM, Stupp R, Balyasnikova IV, Lesniak MS. Activation of 4-1BBL(+) B cells with CD40 agonism and IFN gamma elicits potent immunity against glioblastoma. Journal of Experimental Medicine. 2021;218(1):28.

Li Y, Eshein A, Virk RKA, Eid A, Wu WL, Frederick J, VanDerway D, Gladstein S, Huang K, Shim AR, Anthony NM, Bauer GM, Zhou X, Agrawal V, Pujadas EM, Jain S, Esteve G, Chandler JE, Nguyen TQ, Bleher R, de Pablo JJ, Szleifer I, Dravid VP, Almassalha LM, Backman V. Nanoscale chromatin imaging and analysis platform bridges 4D chromatin organization with molecular function. Science Advances. 2021;7(1):17.

Li Y, Lin H, Zhou W, Sun L, Samanta D, Mirkin CA. Corner-, edge-, and facet-controlled growth of nanocrystals. Science Advances. 2021;7(3).

Liu Y, Mei Y, Han X, Korobova FV, Prado MA, Yang J, Peng Z, Paulo JA, Gygi SP, Finley D, Ji P.Membrane skeleton modulates erythroid proteome remodeling and organelle clearance. Blood. 2021;137(3):398-409.

Murphy OC, Messacar K, Benson L, Bove R, Carpenter JL, Crawford T, Dean J, DeBiasi R, Desai J, Elrick MJ, Farias-Moeller R, Gombolay GY, Greenberg B, Harmelink M, Hong S, Hopkins SE, Oleszek J, Otten C, Sadowsky CL, Schreiner TL, Thakur KT, Van Haren K, Carballo CM, Chong PF, Fall A, Gowda VK, Helfferich J, Kira R, Lim M, Lopez EL, Wells EM, Yeh EA, Pardo CA. Acute flaccid myelitis: cause, diagnosis, and management. Lancet. 2021;397(10271):334-346.

Patel RV, Hirano I, Gonsalves N. Eosinophilic Esophagitis: Etiology and Therapy. Annual Review of Medicine. 2021;72:183-197.

Ramirez-Martinez A, Zhang Y, Chen K, Kim J, Cenik BK, McAnally JR, Cai C, Shelton JM, Huang J, Brennan A, Evers BM, Mammen PPA, Xu L, Bassel-Duby R, Liu N, Olson EN. The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization. Nature Communications. 2021;12(1):690.

Saminathan A, Devany J, Veetil AT, Suresh B, Pillai KS, Schwake M, Krishnan Y. A DNA-based voltmeter for organelles. Nature Nanotechnology. 2021;16(1):12.

Sawicki KT, Sala V, Prever L, Hirsch E, Ardehali H, Ghigo A. Preventing and Treating Anthracycline Cardiotoxicity: New Insights. Annual Review of Pharmacology and Toxicology. 2021;61:309-332.

Tran JR, Paulson DI, Moresco JJ, Adam SA, Yates JR, Goldman RD, Zheng YX. An APEX2 proximity ligation method for mapping interactions with the nuclear lamina. Journal of Cell Biology. 2021;220(1):21.

Vardeny O, Kim K, Udell JA, Joseph J, Desai AS, Farkouh ME, Hegde SM, Hernandez AF, McGeer A, Talbot HK, Anand I, Bhatt DL, Cannon CP, DeMets D, Gaziano JM, Goodman SG, Nichol K, Tattersall MC, Temte JL, Wittes J, Yancy C, Claggett B, Chen Y, Mao L, Havighurst TC, Cooper LS, Solomon SD, Comm I, Investigators. Effect of High-Dose Trivalent vs Standard-Dose Quadrivalent Influenza Vaccine on Mortality or Cardiopulmonary Hospitalization in Patients With High-risk Cardiovascular Disease A Randomized Clinical Trial.JAMA-Journal of the American Medical Association. 2021;325(1):39-49.

Vincent MP, Bobbala S, Karabin NB, Frey M, Liu Y, Navidzadeh JO, Stack T, Scott EA. Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets. Nature Communications. 2021;12(1):648.

Webber JL, Clancy JC, Zhou Y, Yraola N, Homma K, García-Añoveros J. Axodendritic versus axosomatic cochlear efferent termination is determined by afferent type in a hierarchical logic of circuit formation. Science Advances. 2021;7(4).

Yadlapati R, Masihi M, Gyawali CP, Carlson DA, Kahrilas PJ, Nix BD, Jain A, Triggs JR, Vaezi MF, Kia L, Kaizer A, Pandolfino JE. Ambulatory Reflux Monitoring Guides Proton Pump Inhibitor Discontinuation in Patients With Gastroesophageal Reflux Symptoms: A Clinical Trial.Gastroenterology. 2021;160(1):174.