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Pathology Core Facility

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The Pathology Core Facility (PCF) is a centralized, comprehensive, core laboratory providing histology, immunohistochemistry, molecular analysis, and microscopic evaluation services for human tissue-based studies. We are College of American Pathologists (CAP) accredited and CLIA certified with the capability to serve integral marker studies that require biomarker-based treatment arm assignment. In addition to core laboratory services, we perform procurement of fresh biospecimens for clinical trials and biobanking. We facilitate basic, translational, and clinical research at Northwestern University, with laboratories located at downtown Chicago, Illinois.

Services Offered

  • Tissue processing
  • Tissue embedding
  • Tissue Microarrays (TMA)
  • Routine and special sectioning
  • H&E and special histological stains
  • Single and double stains
  • Antibody work-up
Bio Repository
  • Patient screening/consenting
  • Blood/fluid/tissue collection and processing
  • Archival data search and management for tissue withdrawal
Molecular Pathology
  • DNA/RNA extraction from blood
  • DNA/RNA extraction from tissue
  • DNA/RNA extraction from formalin fixed paraffin embedded tissue
  • Tunel Apoptosis
  • RNA Scope
  • H&E analysis
  • Quantitative tissue analysis
  • Pathology review
  • Slide Scanning
  • Digital Image Analysis
Clinical Trials Unit (CTU)
  • Blood/fluid/tissue collection
  • Study initiation/maintenance
Equipment use and training
  • Microtome
  • Cryotome
  • Five-head microscope
  • BSI-II (data management software)
  • Manual TMA Microarray


General Contact
Demirkan B. Gürsel, MSc, PhD
Scientific Director
(312) 503-0324 (office)
(240) 529-3666 (cell)
(312) 503-1148 (fax)

Clinical Trials Unit
Re-el Henderson
Research Lab Manager II
312-503-3439 (office)
312-908-0603 (Lab)
312-695-7619 (Pager)

Jeremy Mathews
Biorepository Laboratory Manager
(312) 503-3753 (office)
(312) 695-8675 (pager)

Director of Pathology Core Facility
Craig Horbinski, MD, PhD
(312) 503-6127


Olson Pavilion, 8th Floor
Room 8-419
710 North Fairbanks Court
Chicago, IL 60611


All manuscripts and grants presenting work supported by this core should include the following acknowledgement:

"This work was supported by the Northwestern University Pathology Core Facility and a Cancer Center Support Grant (NCI CA060553)."