Northwestern University Feinberg School of Medicine
Faculty Profiles
Francesca Elizabeth Duncan, PhD

Francesca Elizabeth Duncan, PhD

Research Associate Professor of Obstetrics and Gynecology

Focus of Work

Bio

Research in the Duncan laboratory tests the overarching hypothesis that deterioration of gamete-intrinsic cellular pathways together with changes in the ovarian micoenvironment contribute to the reproductive age-associated decline in egg quantity and quality. Specifically her group uses mammalian model systems to investigate whether three mechanisms common to systemic aging underlie physiologic and iatrogenic reproductive aging: 1) genomic instability, 2) altered metabolism, and 3) fibrosis. Th...[Read full text]Research in the Duncan laboratory tests the overarching hypothesis that deterioration of gamete-intrinsic cellular pathways together with changes in the ovarian micoenvironment contribute to the reproductive age-associated decline in egg quantity and quality. Specifically her group uses mammalian model systems to investigate whether three mechanisms common to systemic aging underlie physiologic and iatrogenic reproductive aging: 1) genomic instability, 2) altered metabolism, and 3) fibrosis. These insights will help us design targeted interventions to ameliorate reproductive aging, laying the foundation to simultaneously improve women’s fertile-span and health-span across generations.[Shorten text]

Keywords


Education and Certification

  • PhD: University of Pennsylvania, Cell & Molecular Biology (2006)

Contact

Administrative office: 312-503-2172

Robert H Lurie Medical Research Center Room 7-117
303 E Superior
Chicago IL 60611