Northwestern University Feinberg School of Medicine

Department of Dermatology

Clinical Trials

Clinical and Outcomes Research under the direction of the Department of Dermatology is conducted at the Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, and Northwestern Lake Forest Hospital dermatology clinics.

For more information about the research or participation, please call our office at 312-503-5944.

Trials
Tissue repository
Northwestern University’s Department of Dermatology is collecting skin, hair, nail, blood, saliva, skin and/or buccal swabs, and mucous membrane(part of your skin which lines body passages and cavities such as the inside of your mouth or nose), and other tissue samples for use …
Northwestern University’s Department of Dermatology is collecting skin, hair, nail, blood, saliva, skin and/or buccal swabs, and mucous membrane(part of your skin which lines body passages and cavities such as the inside of your mouth or nose), and other tissue samples for use in a biorepository. By operating this biorepository, the Department of Dermatology hopes to develop a better understanding of skin diseases (meaning the knowledge about how cells in the skin behave and react to medical treatments) among researchers at Northwestern University and other approved researchers. This basic knowledge is expected to help the development of more effective patient care and new treatment methods.
-Having specimens collected as part of a standard of care procedure;
-Have a skin disease which researchers want samples of in order to further understand
it; or
-Qualify as a healthy volunteer whose samples researchers can use as control samples
for research.
West, Dennis PWest, Dennis P
  • Map it 676 N. St. Clair St.
    Chicago, IL
STU00009443
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Belback, Madeleine
D1447 - SGX301
To evaluate the safety and effectiveness of the topical ointment (cream), SGX301, in combination with light therapy in patients with cutaneous T-cell lymphoma.
Must be 18 years of age or older, with a clinical diagnosis of Cutaneous T- Cell Lymphoma, Myucosis Fungoides, Stage IA. Stage IB, or Stage IIA, and willing to refrain from sunbathing for duration of the study.
Guitart, JoanGuitart, Joan
  • Map it 676 N. St. Clair St.
    Chicago, IL
NCT02448381 STU00200530
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Bagnowski, Katherine
D1465 - Asthma and AD PROMIS (PEPR)
The purpose of this study is to validate a specific itch tool and its relation to skin disease severity in children ages 5-17 who have symptoms of itch (ie, primary dermatologic conditions: atopic dermatitis, epidermolysis bullosa, ichthyosis, psoriasis, etc; or ot…
The purpose of this study is to validate a specific itch tool and its relation to skin disease severity in children ages 5-17 who have symptoms of itch (ie, primary dermatologic conditions: atopic dermatitis, epidermolysis bullosa, ichthyosis, psoriasis, etc; or other conditions that result in itch such as cancer and pruritic responses to therapy, chronic liver or renal diseases, patients who receive cancer therapy) The study will look at how well Patient Reported Outcomes Measurement Information System (PROMIS) tools uncover meaningful changes in disease status as well as build a list of items relating to pediatric skin diseases and a PRO model for signs and symptoms of skin disease. Surveys can be done remotely.
Paller, AmyPaller, Amy
  • Map it 676 N. St. Clair St.
    Chicago, IL
  • Map it 225 E. Chicago Ave.
    Chicago, IL
STU00202292
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Ramachandran, Divya
(CIRB) - Paller - (Ichthyosis)
Ichthyosis is a group of genetic skin disorders that present with dry, thickened, scaly, or flaky skin. As of today, there is no cure or treatment. Doctors can only treat the dry skin with different types of emollients to soften the scale. A deeper understanding of this…
Ichthyosis is a group of genetic skin disorders that present with dry, thickened, scaly, or flaky skin. As of today, there is no cure or treatment. Doctors can only treat the dry skin with different types of emollients to soften the scale. A deeper understanding of this disease is required to develop better treatments. There are different types of cells and cell-produced signals (biomarkers) that are being studied in order to help find these new treatments. Looking at biomarkers has been successful in helping us to understand other skin disorders better. The purpose of this study is to determine which blood and skin biomarkers characterize ichthyosis in children.
Subjects (1 year to 60 years of age) with Autosomal Recessive Congenital Ichthyosis (ARCI), which includes lamellar Ichthyosis, Netherton Syndrome, or other ichthyosis subtypes will be enrolled.
Healthy control subjects will be enrolled for either a blood sample or skin sample, and/or tape strip samples.
Paller, AmyPaller, Amy
  • Map it 676 N. St. Clair St.
    Chicago, IL
  • Map it 225 E. Chicago Ave.
    Chicago, IL
  • Map it 1131 Techny Rd.
    Northbrook, IL
STU00203051
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Canter, Talia
(CIRB) L1019 Paller - ASP093015 (Harlequin Ichthyosis)
The goal of this study is to understand the pattern of joint pain and what pain management options or treatments have worked for individuals with joint disease related to Harlequin Ichthyosis (HI). Participation in the study will involve complet…
The goal of this study is to understand the pattern of joint pain and what pain management options or treatments have worked for individuals with joint disease related to Harlequin Ichthyosis (HI). Participation in the study will involve completing a one-time survey administered through letter mailing, emailing, link using an online survey, or in person at the Lurie Children’s Dermatology Clinic. The survey will take about 15-30 minutes.
Confirmed diagnosis of Harlequin Ichthyosis (HI) and have complaints of joint pain, difficulty walking, swelling or other similar issues with your muscles and bones.
Paller, AmyPaller, Amy
  • Map it 676 N. St. Clair St.
    Chicago, IL
  • Map it 225 E. Chicago Ave.
    Chicago, IL
  • Map it 1131 Techny Rd.
    Northbrook, IL
STU00203185
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Singh, Prableen
(CIRB) Paller - (AD Biomarkers)
Atopic dermatitis (AD), also called eczema, is a disease in which the skin is dry and scaly with severe itching that may continue despite treatment. A deeper understanding of this disease is required to develop new and better treatments. There are different types of ce…
Atopic dermatitis (AD), also called eczema, is a disease in which the skin is dry and scaly with severe itching that may continue despite treatment. A deeper understanding of this disease is required to develop new and better treatments. There are different types of cells and cell-produced signals (biomarkers) that have been found in adults with AD. Nevertheless, there may be significant differences between AD in children versus adults. The purpose of this study is to determine which blood and skin biomarkers characterize AD in children by looking at the blood and skin biomarkers of children with AD and children without AD.
This study will enroll children ages 0 months to 17 years to collect blood, skin, saliva and tape strip samples in order to look at biomarkers related to AD. Children who have or have not been diagnosed with AD or an atopic condition, such as allergies or asthma.
Paller, AmyPaller, Amy
  • Map it 676 N. St. Clair St.
    Chicago, IL
  • Map it 225 E. Chicago Ave.
    Chicago, IL
  • Map it 1131 Techny Rd.
    Northbrook, IL
STU00203272
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Canter, Talia
D1481 Guitart - Elorac EL-1007-01-01 (Naloxone)
The main goal of this study is to test the efficacy and safety of topical Naloxone for itching in patients with MF.
21 years of age or older with a diagnosis of mycosis fungoides (MF) with itching present on a daily basis for more than one month and willing to fill out a diary for 7 days to provide severity of itch before enrollment.
Guitart, JoanGuitart, Joan
  • Map it 676 N. St. Clair St.
    Chicago, IL
NCT02811783 STU00203078
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Bagnowski, Katherine
D1489 Choi (Topical Steroids for EGFRI PE)
EGFR inhibitors are biologic agents used to treat certain cancers including non-small cell lung, colorectal, head and neck, and pancreatic carcinomas. These agents often have a side effect of an acne like rash that in some cases can be quite severe. This ras…
EGFR inhibitors are biologic agents used to treat certain cancers including non-small cell lung, colorectal, head and neck, and pancreatic carcinomas. These agents often have a side effect of an acne like rash that in some cases can be quite severe. This rash has been shown to be inflammatory in origin but is currently treated with antibiotics if it appears. The main goal of this study is to test if patients treated with steroid cream, (added) which is an anti-inflammatory medication, (added) before a rash develops have a less severe rash than patients who do not use a steroid cream before a rash develops.
Must be 18 years of age or older with a diagnosis of cancer and starting an (changed from 'and') EGFR inhibitor. During the study you must be willing to fill out a daily diary, use sunscreen and cream daily, and fill out 2 questionnaires and have photographs taken every 2 weeks for 4 visits.
Choi, JenniferChoi, Jennifer
  • Map it 676 N. St. Clair St.
    Chicago, IL
NCT03115567 STU00203631
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Erickson, Maia
D1460 Amin - Corrona-PSO-500 Psoriasis Registry
The main purpose of the Corrona Psoriasis registry is to learn more about psoriasis, how doctors treat psoriasis, how well medications and treatments work, and the safety of those treatments.
To be eligible, you need to be 18 years of age or older, have been diagnosed with psoriasis by a dermatologist, and have started on or switched to a systemic biologic psoriasis treatment within the previous 12 months by a Northwestern dermatologist.
Amin, AhmadAmin, Ahmad
  • Map it 676 N. St. Clair St.
    Chicago, IL
STU00203552
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psoriasis

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Paiva Costa TeixeiraFigueiredo, Anna Carolina
D1491 Kundu - Regeneron (Keloid)
Northwestern’s Department of Dermatology is performing a research study to better understand the causes of keloid scars. Keloid scars are solid tissue overgrowths that tend to develop after trauma to the skin.
Subjects who are 18 years of age or older. Have no history of keloids or have a keloid on the earlobe or on another area of your body that either has not been treated or if treated, the treatment took place more than 6 months ago.
Kundu, Roopal VashiKundu, Roopal Vashi
  • Map it 676 N. St. Clair St.
    Chicago, IL
NCT03228693 STU00203462
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keloid

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Ali, Yasmeen
18-052 Le Poole (Microbiome in Vitiligo)
Volunteers are needed for a study on the microbiome of subjects with andwithout vitiligo. For patients with vitiligo and without vitiligo, the studywill include an initial visit, at which time swab or tape strip samples of theskin and swab samples of st…

Volunteers are needed for a study on the microbiome of subjects with andwithout vitiligo. For patients with vitiligo and without vitiligo, the studywill include an initial visit, at which time swab or tape strip samples of theskin and swab samples of stool will be collected. All subjects will be asked tocomplete questionnaires about their skin care regimen and dietary habits. Subjectswith vitiligo will be required to follow up for additional specimen collectionand questionnaire completion after six months and one year.

Volunteers over the age of 18 are eligible to participate. Study is recruiting those with and without vitiligo. 
Le Poole, IsabelleLe Poole, Isabelle
  • Map it 676 N. St. Clair St.
    Chicago, IL
STU00206844
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Pontes, David
18-068 Silverberg - Eli Lilly I4V-MC-JAIW
BREEZE-AD is a clinical research study that will test if an investigational drug isbetter than placebo at treating moderate to severe atopic dermatitis. In thisstudy, you will either get the study drug or a placebo. The effectiveness andsafety of the investig…
BREEZE-AD is a clinical research study that will test if an investigational drug isbetter than placebo at treating moderate to severe atopic dermatitis. In thisstudy, you will either get the study drug or a placebo. The effectiveness andsafety of the investigational drug will be judged by a range of assessmentsthat rate the severity and extent of atopic dermatitis, itch and several othersymptoms, as well as general health status and quality of life.
Age18 and above with a diagnosis of moderate to severe atopic dermatitis for atleast 12 months, and have had inadequate response or intolerance to treatmentwith topical medication in the last 6 months. 
Silverberg, JonathanSilverberg, Jonathan
  • Map it 676 N. St. Clair St.
    Chicago, IL
NCT03334396 STU00206963
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Onate, Alejandra
18-145 Silverberg AbbVie M16-045
MeasureUp 1 is a clinical research study that will test if the study drug “upadacitinib”is better than placebo at treating moderate to severe atopic dermatitis. Inthis study, you will either get the study drug (upadacitinib) or a placebo. Theeffectiveness and safe…
MeasureUp 1 is a clinical research study that will test if the study drug “upadacitinib”is better than placebo at treating moderate to severe atopic dermatitis. Inthis study, you will either get the study drug (upadacitinib) or a placebo. Theeffectiveness and safety of upadacitinib will be judged by a range ofassessments that rate the severity and extent of atopic dermatitis, itch andseveral other symptoms, as well as general health status and quality of life.
Ages12 to 75 with symptoms of moderate to severe atopic dermatitis for at least 3years, and have had inadequate response to treatment with topical medication orhave been taking systemic treatments in the last 6 months. 
Silverberg, JonathanSilverberg, Jonathan
  • Map it 676 N. St. Clair St.
    Chicago, IL
NCT03569293 STU00207913
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Onate, Alejandra
17-188 Choi (PCIA)
This study will test if low-dose oral minoxidil has aneffect on permanent chemotherapy-induced alopecia (defined as hair loss afterthe completion of a chemotherapy regimen that persists for over six months). Inthis study, you will receive the study drug; there is no placebo …

This study will test if low-dose oral minoxidil has aneffect on permanent chemotherapy-induced alopecia (defined as hair loss afterthe completion of a chemotherapy regimen that persists for over six months). Inthis study, you will receive the study drug; there is no placebo option. Theeffectiveness and safety of the treatment will be determined by a range of assessments,including biopsies, images, and subjective evaluation of perceived hair growth.

Age 18 and above with a diagnosis of permanentchemotherapy-induced alopecia and agree to use contraception for the durationof the study.

Choi, JenniferChoi, Jennifer
  • Map it 676 N. St. Clair St.
    Chicago, IL
NCT03831334 STU00206882
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Erickson, Maia
18-142 Silverberg - AbbVie M16-047
ADUp is a clinical research study that will test if the study drug “upadacitinib”in combination with topical corticosteroids (TCS) is better than placebo incombination with TCS at treating moderate to severe atopic dermatitis. In thisstudy, you will either get t…
ADUp is a clinical research study that will test if the study drug “upadacitinib”in combination with topical corticosteroids (TCS) is better than placebo incombination with TCS at treating moderate to severe atopic dermatitis. In thisstudy, you will either get the study drug (upadacitinib) with TCS or a placebowith TCS. The effectiveness and safety of upadacitinib will be judged by arange of assessments that rate the severity and extent of atopic dermatitis,itch and several other symptoms, as well as general health status and qualityof life.
Ages12 to 75 with a diagnosis of moderate to severe atopic dermatitis for at least 3years, and have had inadequate responses or intolerance to treatment withtopical medication within 6 months prior to the baseline visit. 
Silverberg, JonathanSilverberg, Jonathan
  • Map it 676 N. St. Clair St.
    Chicago, IL
NCT03568318 STU00207896
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Onate, Alejandra