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Clinical Trials

Clinical and outcomes research under the direction of the Department of Dermatology is conducted both at the Northwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago dermatology clinics. For more information about the research or participation, please call our office at 312-695-6829.

Feinberg Clinical Trials

Scientists at the medical school are conducting hundreds of clinical trials daily. Learn more about our work via the Feinberg Office of Research Clinical Trials page.

Trials
DERMATOLOGY TISSUE ACQUISITION AND REPOSITORY
Northwestern University’s Department of Dermatology is collecting skin, hair, nail, blood, saliva, skin and/or buccal swabs, and mucous membrane(part of your skin which lines body passages and cavities such as the inside of your mouth or nose), and ot…
Northwestern University’s Department of Dermatology is collecting skin, hair, nail, blood, saliva, skin and/or buccal swabs, and mucous membrane(part of your skin which lines body passages and cavities such as the inside of your mouth or nose), and other tissue samples for use in a biorepository. By operating this biorepository, the Department of Dermatology hopes to develop a better understanding of skin diseases (meaning the knowledge about how cells in the skin behave and react to medical treatments) among researchers at Northwestern University and other approved researchers. This basic knowledge is expected to help the development of more effective patient care and new treatment methods.
-Having specimens collected as part of a standard of care procedure;
-Have a skin disease which researchers want samples of in order to further understand
it; or
-Qualify as a healthy volunteer whose samples researchers can use as control samples
for research.
Rangel, Stephanie MarieRangel, Stephanie Marie
  • Map it 676 N. St. Clair St.
    Chicago, IL
STU00009443
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A Double Blind, Randomized, Vehicle Controlled, Crossover Study to Evaluate the Safety and Efficacy of Topical Naloxone Hydrochloride Lotion 0.5% for the Relief of Pruritus in Patients with the Mycosis Fungoides (MF) or Sézary Syndrome (SS) Forms of Cutaneous T-Cell Lymphoma (CTCL)
The main goal of …
The main goal of this study is to test the efficacy and safety of topical Naloxone for itching in patients with MF.
21 years of age or older with a diagnosis of mycosis fungoides (MF) with itching present on a daily basis for more than one month and willing to fill out a diary for 7 days to provide severity of itch before enrollment.
Guitart, JoanGuitart, Joan
  • Map it 676 N. St. Clair St.
    Chicago, IL
NCT02811783 STU00203078
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The Gut and Skin Microbiome in Vitiligo Disease Progression

Volunteers are needed for a study on the microbiome of subjects with and without vitiligo. For patients with vitiligo and without vitiligo, the study will include an initial visit, at which time swab or tape strip samples of the skin and …

Volunteers are needed for a study on the microbiome of subjects with and without vitiligo. For patients with vitiligo and without vitiligo, the study will include an initial visit, at which time swab or tape strip samples of the skin and swab samples of stool will be collected. All subjects will be asked to complete questionnaires about their skin care regimen and dietary habits. Subjects with vitiligo will be required to follow up for additional specimen collection and questionnaire completion after six months and one year.

Volunteers over the age of 18 are eligible to participate. Study is recruiting those with and without vitiligo.
Le Poole, Isabelle CarolineLe Poole, Isabelle Caroline
  • Map it 676 N. St. Clair St.
    Chicago, IL
STU00206844
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The Impact of Pediatric Skin Disorders: The “Big” Study

The purpose of this study is to understand the possible burden of skin disorders in school-age children, such as its impact on the development of anxiety, depression and relationships with friends. The study will look at the relationship …

The purpose of this study is to understand the possible burden of skin disorders in school-age children, such as its impact on the development of anxiety, depression and relationships with friends. The study will look at the relationship between the burden and how severe or visible the skin problem is.​ Surveys can be done remotely.

Paller, AmyPaller, Amy
  • Map it 225 E. Chicago Ave.
    Chicago, IL
STU00207281
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Wearable sensors and video recording for children (birth to 24 months) to monitor motor development

The purpose of this study is to test flexible body-worn sensors and video technology to provide high-resolution measures of motor development in infants, starting from a very young age and continuin…

The purpose of this study is to test flexible body-worn sensors and video technology to provide high-resolution measures of motor development in infants, starting from a very young age and continuing up to 2 years of age.

This study will enroll up to 200 infants: 100 infants expected to have typical motor development and 100 infants at risk of atypical motor development (based on clinician diagnosis or risk factors such as prematurity, neonatal hypoxic ischemic encephalopathy, neonatal stroke, etc.).

During each study visit, sensors will be placed on the legs, arms, chest, and head using soft bandage wraps or a gentle adhesive. The sensors will record the child’s movements in various postures and tasks. Their movements will also be recorded on video.

These measurements will be completed at the approximate ages of 1-2 weeks, 1 months, 3 months, 6 months, 9 months, 1 year, and 2 years old. Each study visit will take about 1-2 hours.

Compensation will be provided.

If ever it’s too difficult to travel to one of these locations, another option is that we can come to you, and do a study visit at your home.

Infant must meet the following criteria:

  • Legal guardian able and willing to give written consent and comply with study procedures
  • Age less than 24 months
  • Does NOT have open wounds or skin breakdown on the limbs or upper torso
  • Does NOT have missing or incomplete limbs

Jayaraman, ArunJayaraman, Arun
  • Map it 355 E. Erie St.
    Chicago, IL
STU00207900
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Wool Clothing for Atopic Dermatitis
This is a clinical research study that aims to determine if there is an improvement in eczema in children when they wear superfine merino wool clothing. Participants will be randomly assigned to two groups and begin with wool garments for 6 weeks and switch to stan…
This is a clinical research study that aims to determine if there is an improvement in eczema in children when they wear superfine merino wool clothing. Participants will be randomly assigned to two groups and begin with wool garments for 6 weeks and switch to standard garments for 6 weeks or begin with standard garments for 6 weeks and switch to wool garments for a further 6 weeks. Participants will attend follow-up appointments at 3, 6, 9 and 12 weeks where severity of eczema,quality of life, and any side effects will be assessed. Wool clothing and laundry detergent will be provided for the duration of the entire study.

Ages 3 months to 5 years with moderate to severe eczema as determined atinitial visit.

Paller, AmyPaller, Amy
  • Map it 225 E. Chicago Ave.
    Chicago, IL
STU00208730
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An Open Label, Pilot Study Evaluating the Effect of Low-Dose Oral Minoxidil as Treatment of Permanent Chemotherapy-Induced Alopecia

This study will test if low-dose oral minoxidil has aneffect on permanent chemotherapy-induced alopecia (defined as hair loss afterthe completion of a chemotherapy re…

This study will test if low-dose oral minoxidil has aneffect on permanent chemotherapy-induced alopecia (defined as hair loss afterthe completion of a chemotherapy regimen that persists for over six months). Inthis study, you will receive the study drug; there is no placebo option. Theeffectiveness and safety of the treatment will be determined by a range of assessments,including biopsies, images, and subjective evaluation of perceived hair growth.

Age 18 and above with a diagnosis of permanentchemotherapy-induced alopecia and agree to use contraception for the durationof the study.

Choi, Jennifer NamChoi, Jennifer Nam
  • Map it 676 N. St. Clair St.
    Chicago, IL
NCT03831334 STU00206882
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A Phase 2 Study of pembrolizumab in patients with histiocyte/dendritic cell neoplasms and biologically selected subtypes of relapsed/refractory aggressive lymphomas. (Protocol #17-448)

This is a clinical research study to test the safety and effectiveness of the study drug, pembrolizumab, in treat…

This is a clinical research study to test the safety and effectiveness of the study drug, pembrolizumab, in treating patients with an aggressive lymphoma or a histiocyte or dendritic cell neoplasm (tumor) that hasnot responded to or has come back after other treatments. The effectiveness and safety of the treatment will be determined by a range of assessments including biopsies, scans (or imaging tests), as well as general health and performance status.

Age 18 and above with a diagnosis of a histiocyte/dendritic cell neoplasm or relapsed/refractory aggressive lymphoma. Must be willing to provide tissue from a newly obtained biopsy, have normal organ and marrow function and not a candidate for potentially curative therapy at the time of enrollment.

Choi, JaehyukChoi, Jaehyuk
  • Map it 676 N. St. Clair St.
    Chicago, IL
NCT03316573 STU00209675
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lymphoma
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An Open-Label and Long-Term Extension Study to Evaluate the Efficacy and Safety of Ustekinumab in the Treatment of Patients with Ichthyoses
This research is being done to look at the safety and how well ustekinumab works in the treatment of individuals with ichthyosis. Participants will be on study u…
This research is being done to look at the safety and how well ustekinumab works in the treatment of individuals with ichthyosis. Participants will be on study up to approximately 2 years. 
Participants need to be 6 years of age or older and diagnosed with ichthyosis. 
Paller, AmyPaller, Amy
  • Map it 225 E. Chicago Ave.
    Chicago, IL
NCT04549792 STU00212072
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ichthyosis
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A PHASE II STUDY TO EVALUATE THE SAFETY AND EFFICACY OF OQL011 ON VEGFR INHIBITOR-ASSOCIATED HAND-FOOT SKIN REACTION IN CANCER PATIENTS
This study is trying to determine whether an ointment is safe and effective for the treatment of hand-foot skin reaction induced by VEGRF inhibitors. 
Participants must be over the age of 18 and have hand-foot skin reaction after taking anti-cancer medications calls VEGRF inhibitors. 
Choi, Jennifer NamChoi, Jennifer Nam
  • Map it 676 N. St. Clair St.
    Chicago, IL
NCT04088318 STU00211322
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XIRB-Innovative Dermatology Real World Data and Research Collaborative (IMMerse)
This study aims to develop a better understanding of how psoriasis effects different groups of people. Participants will be providing information from their medical records and completing surveys online. 
Participants must be over the age of 18 and with a diagnosis of moderate to severe psoriasis. 
Rangel, Stephanie MarieRangel, Stephanie Marie
  • Map it 676 N. St. Clair St.
    Chicago, IL
STU00212451
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Understanding of factors underlying the pathogenesis of Netherton Syndrome and related skin disorders
This study is to better understand the causes of common skin disorders and to see whether these disorders have increased skin/blood levels of certain proteins which may be causing the disease. Subjec…
This study is to better understand the causes of common skin disorders and to see whether these disorders have increased skin/blood levels of certain proteins which may be causing the disease. Subjects will provided tissue, blood, and saliva/buccal samples at one study visit. 
Subjects must have either one of the following conditions: Netherton Syndrome, atopic dermatitis, rosacea, or no skin conditions (healthy control). 
Paller, AmyPaller, Amy
  • Map it 676 N. St. Clair St.
    Chicago, IL
STU00212039
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A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF CTP-543 IN ADULT PATIENTS WITH MODERATE TO SEVERE ALOPECIA AREATA
This study is for an investigational drug being tested for alopecia areata. This research study will look at two different doses of the investi…
This study is for an investigational drug being tested for alopecia areata. This research study will look at two different doses of the investigational drug compared to placebo when given to research subjects with alopecia areata twice-daily for 24 weeks. 
Subjects need to have at least 50% hair loss on their head due to alopecia areata and be between the ages of 18 and 65. They may not be undergoing treatment with another drug or treatment for alopecia areata or on other treatments that might affect hair regrowth or weaken the immune system. 
Colavincenzo, Maria LColavincenzo, Maria L
  • Map it 676 N. St. Clair St.
    Chicago, IL
NCT04518995 STU00213671
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Kahen, Negar
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XIRB-Systems Biology of Early Atopy (SUNBEAM)

Food allergy affects approximately 5-10% of young children, with highest incidence in the first year of life. Atopic dermatitis (eczema) is a major risk factor for food allergy and other allergic diseases, and it has a significant impact on child healt…

Food allergy affects approximately 5-10% of young children, with highest incidence in the first year of life. Atopic dermatitis (eczema) is a major risk factor for food allergy and other allergic diseases, and it has a significant impact on child health. We hope to learn more about factors that put very young children at higher risk for food allergies and atopic dermatitis (eczema). This study with Dr. Amy Paller (Department of Dermatology), Dr. Emily Miller (Department of Obstetrics and Gynecology), and Dr. Rajesh Kumar (Department of Pediatrics-Allergy and Immunology) will focus on risk factors that may be present before, during, and after birth and through the age of 3 years. Identifying early life markers of those at risk could help with implementation of current prevention methods and discovery of new prevention methods.

This study will enroll pregnant women at any stage who are at least 18 years of age and agree to enroll their child at birth.

Paller, AmyPaller, Amy
  • Map it 675 N. St. Clair St.
    Chicago, IL
  • Map it 676 N. St. Clair St.
    Chicago, IL
  • Map it 675 N. Saint Clair St. Fourteenth Floor, Suite 200
    Chicago, IL
  • Map it 225 E. Chicago Ave.
    Chicago, IL
NCT04798079 STU00213999
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A Multicenter Sample Collection Study Utilizing DermTech's Non-invasive Adhesive Patch Biopsy Kits in Subjects with a Variety of Dermatologic Conditions
This study is being performed to better understand the causes of skin disorders by investigating changes to genes or the way they are expressed in i…
This study is being performed to better understand the causes of skin disorders by investigating changes to genes or the way they are expressed in individuals with a skin condition. This study will also explore the microbiome of the skin. Photographs and non-invasive patch biopsy samples will be collected. 
Participants must be over the age of 18 and have a dermatologic condition. 
Rangel, Stephanie MarieRangel, Stephanie Marie
  • Map it 676 N. St. Clair St.
    Chicago, IL
STU00213998
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Identifying Druggable Targets of Acanthosis Nigricans via Bulk Transcriptomics
This study is being done to understand how Acanthosis Nigricans develops in order to develop targets for drugs to be developed in the future. Participants will be in the study for up to 2 weeks and will provide skin biopsi…
This study is being done to understand how Acanthosis Nigricans develops in order to develop targets for drugs to be developed in the future. Participants will be in the study for up to 2 weeks and will provide skin biopsies and blood. Photos and medical history will also be collected. 
Participants must have Acanthosis Nigricans or meet the criteria to participate as a healthy control. 
Paller, AmyPaller, Amy
  • Map it 676 N. St. Clair St.
    Chicago, IL
STU00214401
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A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of ANB019 in the Treatment of Subjects with Ichthyosis
This study is for an investigational drug for the treatment of ichthyosis. The study will assess the effect of the study drug on skin symptoms, look…
This study is for an investigational drug for the treatment of ichthyosis. The study will assess the effect of the study drug on skin symptoms, look at the amount of study drug in the blood, and how the drug affects the body and general well being. Participants will be on the study for about 10 months. 
Participants needs to be older than 12 years of age and be diagnosed with certain types of ichthyosis. 
Paller, AmyPaller, Amy
  • Map it 676 N. Saint Clair St. Suite 1600
    Chicago, IL
NCT04697056 STU00214170
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ichthyosis
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A Prospective Multi-Arm Blinded Evaluator Within-Subject Randomized Controlled Clinical Study to Investigate the Safety and Effectiveness of RECELL for Repigmentation of Stable Vitiligo Lesions
The purpose of this study is to evaluate the safety andeffectiveness of the RECELL® Device when used on a…
The purpose of this study is to evaluate the safety andeffectiveness of the RECELL® Device when used on areas ofstable vitiligo to produce new pigment in the area. “Stable vitiligo” meansthat the vitiligo areas of skin have notchanged in color or size for at least the last 12 months. The study willevaluate the effect of using RECELL® for repigmentation, which meansadding color back to the vitiligo affected area. This study involves thecombination of laser procedure, study device procedure, and light therapy athome using a device that will be provided to you for the light therapy at home.

To participate in this study, you must have stable vitiligo and eitherone depigmented area large enough to be separated into two study areas OR two separate (unconnected) depigmented areas of skin that are each atleast about 1.5-inch by 1.5 inch (4cm by 4cm) in size.

Kundu, Roopal VashiKundu, Roopal Vashi
  • Map it 676 N. St. Clair St.
    Chicago, IL
NCT04547998 STU00214499
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vitiligo
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