Northwestern University Feinberg School of Medicine
Department of Ophthalmology

Basic Vision Research

Across both the Evanston and Chicago campuses of Northwestern, physicians and scientists are actively pursuing new knowledge to improve the quality of life and options for adults and children with diseases and disorders of the eye. In addition to our faculty members with primary appointments in the Department of Ophthalmology, we collaborate in vision research with many faculty members outside our department, including Biomedical EngineeringDermatology, Medicine, Neurobiology and Physiology.

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RetinaCell Biology and Development
Allada, Ravi

Ravi Allada, MD

Professor of Weinberg College of Arts and Sciences and Pathology

Research is focused on the circadian regulation of sleep behavior using the fruit fly Drosophila and incorporates a variety of approaches including biochemistry, molecular biology, genetics, cell culture, electrophysiology, anatomy and behavior.
Visual Processing
Baker, James

James Baker, PhD

Professor of Physiology

Studies of vestibular and visual sensory systems and the reflex motor outputs to the eyes, neck, and limbs.
Health Services and Outcomes Research
Bryar, Paul J

Paul J Bryar, MD

Professor of Ophthalmology and Pathology

Research is concerned with development of algorithms that can benefit research groups interested in assessing visual acuity for patient-centered outcome.
RetinaCell Biology and Development
Carthew, Richard

Richard Carthew, PhD

Owen L. Coon Professor of Molecular Biosciences

The laboratory is interested in understanding how microRNAs specifically inhibit their target genes and the biological consequences of this regulation. The laboratory works on function of microRNAs to promote the differentiation of photoreceptor neurons in the fruit fly, Drosophila.
RetinaCircuitry and Function
DeVries, Steven H

Steven H DeVries, MD, PhD

Professor of Ophthalmology and Physiology

How visual information is processed by local networks of retinal neurons, and synaptic transmission.
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RetinaDegenerations and Diabetic Retinopathy
Fawzi, Amani A

Amani A Fawzi, MD

Professor of Ophthalmology

Translational approaches to age related macular degeneration and ischemic retinal diseases with a special focus on functional retinal imaging and image-guided interventions.
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Visual Processing
Franconeri, Steven

Steven Franconeri, PhD

Associate Professor of Psychology

The laboratory explores how the visual system transforms a raw image into objects and relations, and why our visual system encounters limitations in how many things we can process at once.
Health Services and Outcomes Research
French, Dustin D

Dustin D French, PhD

Associate Professor of Ophthalmology

Research is concerned with outcomes of cataract surgery, VEGF therapy and health disparities of undiagnosed diabetic retinopathy.
RetinaDegenerations and Diabetic Retinopathy
Henkin, Jack

Jack Henkin, PhD

Research Professor, Chemistry of Life Process Institute, Research Assistant Professor, Chemistry

Drug discovery of anti-angiogenic and anti-cancer agents, primarily focused on small peptides that mimic naturally occurring protective proteins, such as PEDF, from which they are derived. These have shown preclinical promise in treating neovascular retinal disease, uveal melanoma, also ovarian and other cancers. I am also very involved in developing nanoparticle-based intravitreal delivery systems for extended drug release to treat glaucoma and AMD.
Glaucoma
Johnson, Mark

Mark Johnson, PhD

Professor of Biomedical Engineering, Professor of Ophthalmology, Feinberg School of Medicine

Cellular mechanics and the hydrodynamics of glaucoma; the role of lipids in AMD; transport through connective tissues; esophageal transport; and chaos and diffusion.
Visual Processing
Kath, William

William Kath, PhD

Professor of Engineering Sciences and Applied Mathematics and (by courtesy) Neurobiology

Development of computational models of the neural circuitry of the mammalian retina that links the pathways responsible for night and daylight vision.
Glaucoma
Knepper, Paul A

Paul A Knepper, MD

Associate Professor of Ophthalmology

Research focuses on the cause, treatment and prevention of glaucoma and Alzheimer's disease. The laboratory specializes in discovering biomarkers of these disease processes.
Cornea
Kume, Tsutomu

Tsutomu Kume, PhD

Professor of Medicine (Cardiology), Ophthalmology and Pharmacology

Role of FoxC transcription factors in development of the cornea and mechanisms underlying corneal angiogenesis in FoxC mutations.
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RetinaCell Biology and Development
Laurie, Nikia A

Nikia A Laurie, PhD

Assistant Professor of Pediatrics

The laboratory mission is to understand the molecular mechanisms associated with retinoblastoma progression in order to facilitate the identification of novel therapeutic targets.
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RetinaDegenerations and Diabetic Retinopathy
Lavine, Jeremy A

Jeremy A Lavine, MD, PhD

Assistant Professor of Ophthalmology and Medicine (Rheumatology)

Research work focuses upon identification of the cell type that regulates interleukin-6 (IL-6) expression in response to beta-adrenergic receptor (AR) signaling, elucidation of the signaling pathways and transcription factors downstream of the beta2-AR, and identification of new macrophage subtypes within the eye, which are regulated by beta-AR signaling, during choroidal neovascularization (CNV).
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Cornea
Lavker, Robert M

Robert M Lavker, PhD

Professor of Dermatology

The laboratory focuses on the biology of epithelial stem cells and the cornea, and the roles of microRNAs (miRNAs) in regulating corneal homeostasis.
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RetinaDegenerations and Diabetic Retinopathy
Linsenmeier, Robert

Robert Linsenmeier, PhD

Professor of Biomedical Engineering, Professor of Neurobiology, Professor of Ophthalmology, Director of Northwestern Center for Engineering Education Research

The microenvironment of the mammalian retina, including oxygen and pH regulation in health and disease; engineering education research.
RetinaCell Biology and Development
Listernick, Robert H

Robert H Listernick, MD

Professor of Pediatrics (Academic General Pediatrics and Primary Care)

Natural history and treatment of optic pathway tumors in children with neurofibromatosis-1.
Cornea
Longnecker, Richard M

Richard M Longnecker, PhD

Professor of Microbiology-Immunology

The laboratory investigates the function of herpesvirus proteins and the cellular receptors that are important for cornea infection both using in vivo culture models as well as animal models.
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RetinaDegenerations and Diabetic Retinopathy
Molitch, Mark E

Mark E Molitch, MD

Professor of Medicine (Endocrinology)

Pathogenesis and treatment of pituitary tumors and treatment of diabetic complications.
RetinaCell Biology and Development
Oliver, Guillermo

Guillermo Oliver, PhD

Professor of Medicine (Nephrology and Hypertension)

Research is focused on genes and mechanisms that control organ development, including the eye. The laboratory also studies genes involved in development of lymphatic vasculature.
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Glaucoma
Quaggin, Susan E

Susan E Quaggin, MD

Professor of Medicine (Nephrology and Hypertension)

The major research focus is on the genetic and molecular pathways that establish and maintain complex capillary structures, particularly those forming the renal glomerular filtration barrier. Other interests include the mechanisms of Schlemm’s canal development and glaucoma.
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RetinaCell Biology and Development
Sarthy, Vijay

Vijay Sarthy, PhD

Professor of Ophthalmology and Cell and Molecular Biology

Neuron-glia interactions in the retina; Roles of Müller (glia) cells in the pathogenesis of retinal degenerations and diabetic retinopathy.
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RetinaCircuitry and Function
Schmidt, Tiffany

Tiffany Schmidt, PhD

Assistant Professor of Neurobiology

The research is concerned with the role of retinal ganglion cell (RGC) subtypes in specific visual functions with emphasis on intrinsically photosensitive RGCs (ipRGCs).
RetinaCircuitry and Function
Schwartz, Gregory W

Gregory W Schwartz, PhD

Assistant Professor of Ophthalmology, Physiology and Weinberg College of Arts and Sciences

The research program in computational neuroscience and systems neurophysiology relates to our understanding of how ganglion cells respond to various light stimuli. In addition, the laboratory studies the visual processing circuits in the inner synaptic layer of the retina.
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Visual Processing
Segraves, Mark

Mark Segraves, PhD

Professor of Neurobiology

The laboratory uses the eye movement system as a model for how the brain of primates, including man, controls a variety of movements. Research work focuses upon areas of the rhesus monkey's prefrontal cortex and midbrain that help to control eye movements.
Health Services and Outcomes Research
Starren, Justin B

Justin B Starren, MD, PhD

Professor of Preventive Medicine (Health and Biomedical Informatics) and Medical Social Sciences

Development of intuitive, novel Human Computer Interfaces for healthcare.
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Visual Processing
Suzuki, Satoro

Satoro Suzuki, PhD

Professor of Psychology

A major goal of the research is to understand the cortical mechanisms that enable people to perceive coherent global forms from retinal illumination patterns that are often ambiguous as to what meaningful forms and configurations are present.
Glaucoma
Troy, John B.

John Troy, PhD

Professor of Biomedical Engineering, Professor of Ophthalmology, Feinberg School of Medicine

Processing and analysis of images by the mammalian visual system; functional circuitry of the retina; signal theory applied to visual physiology; light adaptation; neural coding; visual prostheses; electrode technology for neural recording and stimulation; glaucoma.
RetinaFunctional Imaging
Zhang, Hao

Hao Zhang, PhD

Professor of Biomedical Engineering, Professor of Ophthalmology, Feinberg School of Medicine

Novel optical imaging technologies for ophthalmic application.
RetinaCircuitry and Function
Zhu, Yongling

Yongling Zhu, PhD

Assistant Professor of Ophthalmology and Physiology

The laboratory studies the structure and function of genetically isolated retina circuits with anatomical, physiological and imaging tools.
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Yongling Zhu Lab

Research Description

The laboratory develops genetic and viral technologies to delineate and target cell types in the retina, followed by combining electrophysiology, functional imaging and optogenetics to understand how specific subsets of neurons integrate into larger circuits that compute different neural representations of the visual world.

For more information, visit the faculty profile for Yongling Zhu, PhD.

Select Publications

  • Jo, A., Xu, J., Deniz, S., Cherian, S., DeVries, S.H., and Zhu, Y. (2018) Intersectional strategies for targeting amacrine and ganglion cell types in the mouse retina
  • Xu, J. and Zhu, Y. (2018) A rapid in vitro method to flip back the Double-fLoxed Inverted Open reading frame in a plasmid BMC Biotechnol. 18(1):52
  • Zhu, Y., Xu, J., Hauswirth, W.W., and DeVries, S.H.* (2014). Genetically targeted binary labeling of retinal neurons. J. Neuroscience. 34(23):7845–7861
  • Zhu, Y., Xu, J., and Heinemann, S. F. (2009). Two pathways of synaptic vesicle retrieval revealed by single vesicle imaging. Neuron, 61(3):397-411
  • Zhu, Y. and Stevens, C. F. (2008) Probing synaptic vesicle fusion by altering mechanical properties of the neuronal surface membrane Proc Natl Acad Sci U S A. 105(46):18018-18022

 

Lab Staff

  • Sercan Deniz: Postdoc fellow
  • Andrew Jo: Graduate student

Vijay P. Sarthy Lab

Research Description

The pattern of gene expression in eukaryotic cells is strongly influenced by interactions with neighboring cells. When cell-cell interactions are perturbed, changes in cellular gene activity are often observed. In the vertebrate retina, inherited or acquired rod and cone degeneration results in disruption of normal interactions between photoreceptors and their support cells, the Müller cells. Under these conditions many genes such as the glial intermediate filament protein (GFAP) gene, ciliary neurotrophic factor (CNTF) gene and basic fibroblast growth factor (bFGF) gene are upregulated in neighboring Müller cells.

We use techniques such as single cell RT-PCR and differential display to study changes in gene expression patterns in Müller cells. Major goals of our current research are to elucidate the molecular mechanisms responsible for transcriptional activation and to determine the extracellular inductive signal and the signal transduction pathways involved. Our recent cell transfection studies and experiments with GFAP-lacZ transgenic mice suggest that GFAP gene activation in Müller cells is regulated by a cell type-specific, inducible enhancer and that GFAP gene is activated through the JAK-STAT pathway. The work on gene regulation is crucial for development of strategies for using Müller cell-specific promoters to test the biological effects of growth factors and cytokines in animals models of retinal degeneration and more importantly for designing cell type-specific vectors for targeted delivery in gene therapy.

A second project is concerned with molecular cloning, regulation and function of neurotransmitter transporters—a family of membrane proteins that are involved in the uptake of neurotransmitters. We are particularly interested in the role of taurine and glutamate transporters in retinal ischemia and glutamate neurotoxicity. We have already cloned and characterized GABA, taurine and glutamate transporters from retina. We have also localized the transporters to specific retinal cell types and shown that phosphorylation may play a key role in regulating transporter function.

For more information visit Dr. Sarthy's faculty profile page.

Publications

View Dr. Sarthy's publications at PubMed

Contact

Email Dr. Sarthy

Phone 312- 503-3031

Tsutomu Kume Lab

Research Description

Cardiovascular development is at the center of all the work that goes on in the Kume lab. The cardiovascular system is the first functional unit to form during embryonic development and is essential for the growth and nurturing of other developing organs. Failure to form the cardiovascular system often leads to embryonic lethality and inherited disorders of the cardiovascular system are quite common in humans. The causes and underlying developmental mechanisms of these disorders, however, are poorly understood. A particular emphasis in our laboratory has recently been the study of cardiovascular signaling pathways and transcriptional regulation in physiological and pathological settings using mice as animal models, as well as embryonic stem (ES) cells as an in vitro differentiation system. The ultimate goal of our research is to provide new insights into the mechanisms that lead to the development of therapeutic strategies designed to treat clinically relevant conditions of pathological neovascularization.

Publications

View Dr. Kume's publications on PubMed.

For more information, visit the faculty profile for Tsutomu Kume, PhD.

Contact Us

Contact Dr. Kume at 312-503-0623 or the Kume Lab at 312-503-3008.

Staff Listing

Austin Culver
MD Candidate
312-503-3008

Anees Fatima
Research Assistant Professor
312-503-0554

Christine Elizabeth Kamide
Senior Research Technologist
312-503-1446

Erin Lambers
PhD Candidate
312-503-5652

Ting Liu
Senior Research Technologist
312-503-3008

Jonathon Misch
Research Technologist
312-503-6153

Susan Quaggin Lab

Our lab focuses on the basic biology of vascular tyrosine kinase signaling in development and diseases of the blood and lymphatic vasculature.  Our projects include uncovering the molecular mechanisms of diabetic vascular complications, thrombotic microangiopathy, glomerular diseases and glaucoma.  Utilizing a combination of mouse genetic, cell biologic and proteomic approaches, we have identified key roles for Angiopoietin-Tie2 and VEGF signaling in these diseases.  Members of the lab are developing novel therapeutic agents that target these pathways.  

Faculty Profile

Susan Quaggin, MD

Steven DeVries Lab

Research Description

Parallel processing is one of the key strategies used by the visual system. In the mammalian retina, the responses of the cone photoreceptor inputs are temporally uniform when stimulated with equivalent lights. However, the retinal ganglion cell outputs can be grouped into 30 to 35 different classes based on the temporal properties of their light responses, morphology and central targets. Our goal is to characterize the processing in the parallel retinal networks that leads to these different responses. We study retinal processing by using a very basic approach: We isolate the excitatory “skeleton” of the retina — the cones, bipolar cells and ganglion cells — and systematically determine how signals are modified at each synapse by recording from pairs of pre- and post-synaptic neurons in a retinal slices and whole mounts. In the outer retina, we record from cone and bipolar cell pairs; whereas, in the inner retina, our goal is to optogenetically stimulate bipolar cells and record from identified postsynaptic ganglion cells. In collaboration with the Zhu lab, we identify and functionally probe the connects between bipolar and ganglion cells by using a retrograde rabies virus tracer that is introduced into ganglion cells at their axon terminals.

For more information, visit the faculty profile for Steven H. DeVries, MD, PhD.

Selected Publications

  • Saszik, S. & DeVries, S. H. (2012). A mammalian retinal bipolar cell uses both graded changes in membrane potential and all-or-nothing Na+ spikes to encode light. Journal of Neuroscience. 32, 297-307.
  • Sher, A. & DeVries, S.H. (2012). A non-canonical pathway for mammalian blue-green color vision. Nature Neuroscience 15, 952-953.
  • Lindstrom, S.H., Ryan, D.G., Shi, J. & DeVries, S.H. (2014). Kainate receptor subunit diversity underlying response diversity in retinal Off bipolar cells. Journal of Physiology, 592, 1457-1477.
  • Zhu, Y., Xu, J., Hauswirth, W.W., & DeVries, S.H. (2014). Genetically targeted binary labeling of retinal neurons. Journal of Neuroscience 34, 7845-7861.
  • Grabner, C.P., Ratliff, C.P., Light, A.C. & DeVries, S.H. (2016). Mechanism of high frequency signaling at a depressing ribbon synapse. Neuron 91, 133-145.

 

Lab Staff

  • Jun Shi
    Lab manager
  • Eric Schwartz
    Adjunct Professor
  • Sercan Deniz
    Postdoc

Robert Lavker Lab

Research Description

The Lavker laboratory focuses on the biology of epithelial stem cells and the roles of microRNAs (miRNAs) in regulating epithelial homeostasis. In collaboration with Tung-Tien Sun (NYU Medical School), the lab identified and characterized stem cells of the epidermis, hair follicle and corneal epithelium. We have demonstrated that the hair follicle stem cells (located in the bulge region of the follicle) are pluripotent; capable of forming the hair shaft as well as the epidermis. Collectively, these studies have been of major importance for their implications regarding tissue regeneration, hair follicle growth, and carcinogenesis.

Initial investigations on microRNAs (miRNAs) focused on corneal epithelial-preferred miRNAs. Specifically, miR-205 undergoes a unique form of regulation through an interaction with the corneal-preferred miR-184 to maintain SHIP2 levels. SHIP2, a lipid phosphatase, is a target of miR-205, which enhances keratinocyte survival through PI3K-Akt signaling. This miRNA also positively regulates keratinocyte migration by altering F-actin organization and decreasing cell-substrate adhesion.

Recently, the lab has focused on miR-31, which targets factor inhibiting hypoxia-inducible factor-1 (FIH-1). FIH-1 impairs epithelial differentiation via attenuation of Notch signaling. Our results define a previously unknown mechanism for keratinocyte fate decisions where Notch signaling potential is, in part, controlled through a miR-31/FIH-1 nexus. This provides a rationale for development of treatment regimens in patients with diseases affecting abnormal epithelial differentiation (e.g., psoriasis) using inhibitors of FIH-1.

We have also demonstrated that miR-31 targets FIH-1 to positively regulate corneal epithelial glycogen metabolism, which results in the accumulation of glycogen. Increased glucose in the form of glycogen may be a mechanism by which the corneal epithelium is able to withstand periods of hypoxia during eyelid closure or extended contact lens wear. Thus miR-31 may function as a novel means if protecting the corneal epithelium from hypoxic stress.

Most recently, the laboratory has defined the microRNA expression patterns of the stem cell-enriched limbal basal cells and has begun to identify targets that are unique to the limbal epithelium. This should lead to an understanding of how miRNAs regulate epithelial stem cells.

Publications

For publication information and more, see the Lab faculty’s profiles:

Robert Lavker, PhDHan Peng, PhD

Contact Lavker Lab

Contact the Lavker Lab at 312-503-2043 or visit us on campus in the Montgomery Ward Building, 303 E. Chicago Avenue, Ward 9-120, Chicago, Illinois, 60611.

Faculty

Robert M. Lavker, PhD, Han Peng, PhD

Post-doctoral Fellows

Jong Kook Park, PhD, Nihal Kaplan, PhD

Research Associates

Wending Yang, PhD

Richard Longnecker Lab

Research Description

Research in the Longnecker laboratory focuses on herpes simplex virus (HSV) and Epstein-Barr virus (EBV). These viruses typically cause self-limiting disease within the human population but both can be associated with serious complications. EBV is associated with variety of hematopoietic cancers such as African Burkitt lymphoma, Hodgkin Lymphoma and adult T-cell leukemia. EBV-associated lymphoproliferative disease occurs in individuals with congenital or acquired cellular immune deficiencies. The two notable epithelial diseases associated with EBV infection are nasopharyngeal cancer and oral hairy leukoplakia. Similar to EBV, HSV latent infections are very common in humans. HSV typically does not cause severe disease but is associated with localized mucocutaneous lesions, but in some cases can cause meningitis and encephalitis. The Longnecker laboratory focuses on several aspects of EBV and HSV replication and pathogenesis. First, the molecular basis EBV transformation and how it relates to cancer is being investigated. The laboratory is currently screening selective inhibitors that may be beneficial in EBV-associated cancers such as Hodgkin lymphoma, Burkitt lymphoma and proliferative disorders that occur in HIV/AIDS and transplant patients. Second, the laboratory is investigating herpesvirus latency in the human host and pathogenesis associated with infections in humans. In this regard, the laboratory is developing animal models for EBV and HSV infections. Finally, the laboratory is investigating the function of herpesvirus encoded proteins and the cellular receptors that are important for infection both using in vivo culture models as well as animal models. Ultimately, studies by the Longnecker laboratory may provide insight for the development of novel therapeutics for the treatment of herpesvirus infections in humans and better understanding of the herpesvirus life cycle in the human host

For lab information and more, see Dr. Longnecker's faculty profile.

Publications

See Dr. Longnecker's publications on PubMed.

Contact

Contact Dr. Longnecker at 312-503-0467 or the lab at 312-503-0468 or 312-503-9783.

Lab Staff

Research Faculty

Jia Chen, Qing Fan, Kamonwan "Pear" Fish, Masato Ikeda

Adjunct Faculty

Sarah Connolly, Michelle Swanson-Mungerson

Graduate Students

Daniel Giraldo Perez, Seo Jin Park, Richard Sora, Jr.

Technical Staff

Sarah Kopp, Rachel Riccio, Samantha Schaller, Nanette Susmarski

Nikia Laurie Lab

Research Description

Retinoblastoma, the most common pediatric cancer of the eye, is a devastating and sometimes fatal pediatric cancer. Within the United States, the majority of retinoblastoma patients are diagnosed before their second birthday and many lose their sight due to this disease. Outside of the United States, advanced retinoblastoma is an even greater clinical challenge in developing countries, where the mortality rate among children diagnosed with advanced metastatic retinoblastoma is as high as 80%.

Our laboratory mission is to understand the molecular mechanisms associated with retinoblastoma progression in order to facilitate the identification of novel therapeutic targets. We are accomplishing our mission by studying both genetic and epigenetic changes that occur during retinoblastoma progression in human retinoblastoma tumors and in retinoblastoma model systems. Defining these changes is particularly valuable for the purposes of identifying novel targets for chemotherapeutic interventions.

Publications

See Dr. Laurie's publications in PubMed.

Lab Staff

Graduate Students

Vanessa Montoya

Contact

Dr. Laurie

Justin B. Starren Lab

Research Description

My current research focuses on new ways to make health care computing more useful. This includes developing intuitive, novel Human Computer Interfaces (HCI) for health care, including working on the design of graphical icons for clinical applications, addressing data overload for clinicians and issues in affective computing. A related line of research is developing methods for the integration of clinic research computing into clinical care.

For more information, visit the faculty profile of Justin Starren, MD/PhD or the Starren lab site.

Publications

View Dr. Starren's publications at PubMed

Contact

Email Dr. Starren

Jeremy Lavine Lab

Research Description

My research lab focuses on translational, basic science projects that aim to develop new therapeutics for ocular angiogenesis independent of vascular endothelial growth factor (VEGF). Neovascular age-related macular degeneration (nAMD) is the leading cause of visual impairment in the developed world. Currently, humanized anti-VEGF antibodies are the gold standard for the treatment of nAMD. Patients currently undergo frequent (up to monthly) injections of anti-VEGF antibodies into the vitreous cavity. The average patient achieves 1-2 lines of visual acuity gain, but 15% of patients still lose vision despite maximal anti-VEGF therapy. Although 15% appears small, given the high prevalence of nAMD, this amounts to 2.5 million patients worldwide. For these poorly responsive patients, there is a clear unmet need for alternative, VEGF-independent therapeutic options.

            Macrophage recruitment is central in nAMD pathogenesis. Choroidal neovascularization (CNV) is the pathological hallmark of nAMD. In human histopathology studies of excised CNV membranes, macrophages are readily apparent. In mice, nAMD is modeled by laser-induced injury, which causes CNV membrane formation. Laser-induced CNV formation is robustly inhibited by chemical or genetic macrophage depletion. Based upon these accepted dogma, intravitreal steroids were attempted for nAMD treatment and are unfortunately ineffective. I hypothesize that steroids anti-inflammatory properties are too broad and specific anti-macrophage therapies are necessary. Furthermore, macrophages are highly plastic and heterogenous populations, including pro-inflammatory, pro-restorative, pro-fibrotic, and pro-angiogenic subtypes. My lab’s focus is to identify macrophage heterogeneity in CNV, delineate pro-angiogenic macrophage subtypes, and attempt to develop therapties against pro-angiogenic macrophages for nAMD.

For more information, visit the faculty profile for Dr. Lavine.

Selected Publications

  • A. Lavine, Y. Sang, S. Wang, M.S. Ip, N. Sheibani. “Attenuation of choroidal neovascularization by beta(2)-adrenoreceptor antagonism” (2013) JAMA Ophthalmology, 131(3):376-382. (PMID: 23303344)
  • Nourinia, M. Rezaei Kanavi, A. Kaharkaboudi, S.I. Taghavi, S.J. Aldavood, S.R. Darjatmoko, S. Wang, Z. Gurel, J.A. Lavine, S. Safi, H. Ahmadieh, N. Daftarian, N. Sheibani. “Ocular safety of intravitreal propranolol and its efficacy in attenuation of choroidal neovascularization.” (2015) Investigative Ophthalmology and Visual Science, 56: 8228-8235. (PMID: 26720475)
  • A. Lavine, M. Farnoodian, S. Wang, S.R. Darjatmoko, L.S. Wright, D.G. Gamm, M.S. Ip, N. Sheibani. “beta2-Adrenergic receptor antagonism attenuates CNV through inhibition of VEGF and IL-6 expression” (2017) Investigative Ophthalmology and Visual Sciences, 58 (1): 299-308. (PMID: 28114591)
  • M. Hendrick, J. A. Lavine, A. Domalpally, A.D. Kulkarni, M.S. Ip. “Propranolol for proliferative diabetic retinopathy.” (2018) OSLI Retina, 49 (1): 35-40. (PMID: 29304264).
  • A. Lavine, A.D. Singh, A. Sharma, K. Baynes, C.Y. Lowder, S.K. Srivastava. “Ultra-Widefield Multimodal Imaging in Primary Central Nervous System Lymphoma with Ophthalmic Involvement.” (2018) Retina, Epub ahead of print. (PMID 30044267)

Contact Dr. Lavine

Lab Phone: 312-503-0487

Amani Fawzi Lab

Research Description

Fawzi’s research lab is focused on translational approaches to age-related macular degeneration, ischemic retinal diseases and neurodegenerative diseases with a special focus on functional retinal imaging and image-guided interventions.

For more information, visit the faculty profile for Amani A. Fawzi, MD.

Selected Publications

  • Soetikno BT, Beckmann L, Zhang X, Fawzi AA, Zhang HF. Visible-light optical coherence tomography oximetry based on circumpapillary scan and graph-search segmentation. Biomed Opt Express. 2018 Jul 10;9(8):3640-3652.
  • Treister AD, Nesper PL, Fayed AE, Gill MK, Mirza RG, Fawzi AA. Prevalence of subclinical CNV and choriocapillaris nonperfusion in fellow eyes of unilateral exudative AMD on OCT angiography. Transl Vis Sci Technol. 2018 Oct 1;7(5):19.
  • Ashraf M, Nesper PL, Jampol LM, Yu F, Fawzi AA. Statistical model of optical coherence tomography angiography parameters that correlate with severity of diabetic retinopathy. Invest Ophthalmol Vis Sci. 2018 Aug 1;59(10):4292-4298.
  • Lajko M, Cardona HJ, Taylor JM, Farrow KN, Fawzi AA. Photoreceptor oxidative stress in hyperoxia-induced proliferative retinopathy accelerates rd8 degeneration. PLoS One. 2017 Jul 3;12(7):e0180384.
  • Lajko M, Cardona HJ, Taylor JM, Shah RS, Farrow KN, Fawzi AA. Hyperoxia-induced proliferative retinopathy: Early interruption of retinal vascular development with severe and irreversible neovascular disruption. PLoS One, 2016, 11(11): e0166886.

Lab Staff

  • Suzie Lee
  • Tom Tedeschi
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