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Innovative, collaborative research.

 

The Department of Neuroscience at Northwestern University Feinberg School of Medicine is devoted to outstanding research and committed to excellence in education. Our faculty participate in teaching medical and graduate students and are proud of their contribution to this important enterprise.

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What We Do

Research

Our research spans the full spectrum of investigation into neural function and dysfunction, bridging the levels of genes, molecules, dendrites, axons, cell types, circuits, systems and behavior.

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Education

In addition to directing their own independent research programs, our faculty are responsible for supervising the research training of postdoctoral fellows and graduate students.

EXPLORE EDUCATION OPPORTUNITIES

Recent Publications

Prognostic value of preoperative mechanical hyperalgesia and neuropathic pain qualities for postoperative pain after total knee replacement.

Vigotsky AD, Cong O, Pinto CB, Barroso J, Perez J, Petersen KK, Arendt-Nielsen L, Hardt KD, Manning D, Apkarian AV, Branco P.

Eur J Pain. 2024 Jun 8. doi: 10.1002/ejp.2295. Online ahead of print.

Phenotypical, genotypical and pathological characterization of the moonwalker mouse, a model of ataxia.

Sekerková G, Kilic S, Cheng YH, Fredrick N, Osmani A, Kim H, Opal P, Martina M.

Neurobiol Dis. 2024 Jun 1;195:106492. doi: 10.1016/j.nbd.2024.106492. Epub 2024 Apr 2.

Correction: Neuron type-specific proteomics reveals distinct Shank3 proteoforms in iSPNs and dSPNs lead to striatal synaptopathy in Shank3B-/- mice.

Wang YZ, Perez-Rosello T, Smukowski SN, Surmeier DJ, Savas JN.

Mol Psychiatry. 2024 Mar 28. doi: 10.1038/s41380-024-02543-3. Online ahead of print.

Task-driven neural network models predict neural dynamics of proprioception.

Marin Vargas A, Bisi A, Chiappa AS, Versteeg C, Miller LE, Mathis A.

Cell. 2024 Mar 28;187(7):1745-1761.e19. doi: 10.1016/j.cell.2024.02.036. Epub 2024 Mar 21.

Neuron type-specific proteomics reveals distinct Shank3 proteoforms in iSPNs and dSPNs lead to striatal synaptopathy in Shank3B-/- mice.

Wang YZ, Perez-Rosello T, Smukowski SN, Surmeier DJ, Savas JN.

Mol Psychiatry. 2024 Mar 14. doi: 10.1038/s41380-024-02493-w. Online ahead of print.

Disrupted sleep-wake regulation in the MCI-Park mouse model of Parkinson's disease.

Summa KC, Jiang P, González-Rodríguez P, Huang X, Lin X, Vitaterna MH, Dan Y, Surmeier DJ, Turek FW.

NPJ Parkinsons Dis. 2024 Mar 11;10(1):54. doi: 10.1038/s41531-024-00670-w.

Voluntary co-contraction of ankle muscles alters motor unit discharge characteristics and reduces estimates of persistent inward currents.

Gomes MM, Jenz ST, Beauchamp JA, Negro F, Heckman CJ, Pearcey GEP.

bioRxiv [Preprint]. 2024 Mar 3:2024.02.28.582534. doi: 10.1101/2024.02.28.582534.

Quantifying differentiation of progenitor populations using cerebral organoid models for neurodevelopmental disorders.

Schroder AL, Fairbanks-Santana M, Rakotomamonjy J, Guemez-Gamboa A.

STAR Protoc. 2024 Mar 15;5(1):102904. doi: 10.1016/j.xpro.2024.102904. Epub 2024 Feb 29.

Multipotent bone marrow cell-seeded polymeric composites drive long-term, definitive urinary bladder tissue regeneration.

Bury MI, Fuller NJ, Wang X, Chan YY, Sturm RM, Oh SS, Sofer LA, Arora HC, Sharma TT, Nolan BG, Feng W, Rabizadeh RR, Barac M, Edassery SS, Goedegebuure MM, Wang LW, Ganesh B, Halliday LC, Seniw ME, Edassery SL, Mahmud NB, Hofer MD, McKenna KE, Cheng EY, Ameer GA, Sharma AK.

PNAS Nexus. 2024 Jan 30;3(2):pgae038. doi: 10.1093/pnasnexus/pgae038. eCollection 2024 Feb.

GABAergic regulation of striatal spiny projection neurons depends upon their activity state.

Day M, Belal M, Surmeier WC, Melendez A, Wokosin D, Tkatch T, Clarke VRJ, Surmeier DJ.

PLoS Biol. 2024 Jan 31;22(1):e3002483. doi: 10.1371/journal.pbio.3002483. eCollection 2024 Jan.

Basic Science Administration

Our department is supported by the Basic Science Administration group. The team provides assistance related to research and financial administration, professional affairs, facilities and communications.

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Starzl Academy

Physician-Scientist Training & Resources

We offer a wide range of resources, mentorship opportunities and formal training programs to help our residents and fellows excel as physician-scientists. Explore all of the resources and hear from housestaff who are making research a major part of their career development plans.

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