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Innovative, collaborative research.

The Department of Neuroscience at Northwestern University Feinberg School of Medicine is devoted to outstanding research and committed to excellence in education. Our faculty participate in teaching medical and graduate students and are proud of their contribution to this important enterprise.

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What We Do

Research

Our research spans the full spectrum of investigation into neural function and dysfunction, bridging the levels of genes, molecules, dendrites, axons, cell types, circuits, systems and behavior.

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Education

In addition to directing their own independent research programs, our faculty are responsible for supervising the research training of postdoctoral fellows and graduate students.

EXPLORE EDUCATION OPPORTUNITIES

Recent Publications

μ-opioid receptor modulation of the glutamatergic/GABAergic midbrain inputs to the mouse dorsal hippocampus.

Kim HR, Dey S, Sekerkova G, Martina M.

J Neurosci. 2024 Sep 9:e0653242024. doi: 10.1523/JNEUROSCI.0653-24.2024. Online ahead of print.

Hand-jaw coordination as mice handle food is organized around intrinsic structure-function relationships.

Barrett JM, Martin ME, Gao M, Druzinsky RE, Miri A, Shepherd GMG.

J Neurosci. 2024 Sep 9:e0856242024. doi: 10.1523/JNEUROSCI.0856-24.2024. Online ahead of print.

Acetyl-DL-leucine in two individuals with REM sleep behavior disorder improves symptoms, reverses loss of striatal dopamine-transporter binding and stabilizes pathological metabolic brain pattern-case reports.

Oertel WH, Janzen A, Henrich MT, Geibl FF, Sittig E, Meles SK, Carli G, Leenders K, Booij J, Surmeier DJ, Timmermann L, Strupp M.

Nat Commun. 2024 Sep 2;15(1):7619. doi: 10.1038/s41467-024-51502-7.

Body mass index associated with respiration predicts motion in resting-state functional magnetic resonance imaging scans.

Huang S, Vigotsky AD, Apkarian AV, Huang L.

Hum Brain Mapp. 2024 Sep;45(13):e70015. doi: 10.1002/hbm.70015.

Voluntary co-contraction of ankle muscles alters motor unit discharge characteristics and reduces estimates of persistent inward currents.

Gomes MM, Jenz ST, Beauchamp JA, Negro F, Heckman CJ, Pearcey GEP.

J Physiol. 2024 Sep;602(17):4237-4250. doi: 10.1113/JP286539. Epub 2024 Aug 19.

Multiple layers of diversity govern the cell type specificity of GABAergic input received by mouse subicular pyramidal neurons.

Borjas NC, Anstötz M, Maccaferri G.

J Physiol. 2024 Sep;602(17):4195-4213. doi: 10.1113/JP286679. Epub 2024 Aug 14.

Prognostic value of preoperative mechanical hyperalgesia and neuropathic pain qualities for postoperative pain after total knee replacement.

Vigotsky AD, Cong O, Pinto CB, Barroso J, Perez J, Petersen KK, Arendt-Nielsen L, Hardt KD, Manning D, Apkarian AV, Branco P.

Eur J Pain. 2024 Sep;28(8):1387-1401. doi: 10.1002/ejp.2295. Epub 2024 Jun 8.

Correction: Neuron type-specific proteomics reveals distinct Shank3 proteoforms in iSPNs and dSPNs lead to striatal synaptopathy in Shank3B-/- mice.

Wang YZ, Perez-Rosello T, Smukowski SN, Surmeier DJ, Savas JN.

Mol Psychiatry. 2024 Sep;29(9):2919. doi: 10.1038/s41380-024-02543-3.

Movement-related increases in subthalamic activity optimize locomotion.

Callahan JW, Morales JC, Atherton JF, Wang D, Kostic S, Bevan MD.

Cell Rep. 2024 Aug 27;43(8):114495. doi: 10.1016/j.celrep.2024.114495. Epub 2024 Jul 26.

Ca2+-dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapses.

Zhai S, Otsuka S, Xu J, Clarke VRJ, Tkatch T, Wokosin D, Xie Z, Tanimura A, Agarwal HK, Ellis-Davies GCR, Contractor A, Surmeier DJ.

Cell Rep. 2024 Aug 27;43(8):114540. doi: 10.1016/j.celrep.2024.114540. Epub 2024 Jul 25.

Basic Science Administration

Our department is supported by the Basic Science Administration group. The team provides assistance related to research and financial administration, professional affairs, facilities and communications.

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Starzl Academy

Physician-Scientist Training & Resources

We offer a wide range of resources, mentorship opportunities and formal training programs to help our residents and fellows excel as physician-scientists. Explore all of the resources and hear from housestaff who are making research a major part of their career development plans.

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