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Northwestern University Feinberg School of Medicine
Institute for Artificial Intelligence in Medicine

Publications

Browse the list below to see the latest scientific publications stemming from our institute faculty’s work. To view publications of specific AI faculty, please visit Membership and select a profile link.

  1. Borlaug BA, Chirinos JA, Lewis GD, Redfield MM, Bertoni AG, Cadeiras M, Chiamvimonvat N, Desai AS, Givertz MM, Kass DA  et al.  Rationale and Design of the HeartShare/AMP-HF Deep Phenotyping Study to Improve Understanding of Heart Failure With Preserved Ejection Fraction.  JACC Heart Fail  2025 Dec;13(12):102714. doi:10.1016/j.jchf.2025.102714
  2. Abahuje E, Houskamp EJ, Silva Pinheiro do Nascimento J, Agha EM, Thompson WK, Michelson KN, Naidech A  Patient and clinician perspectives in the use of machine learning and artificial intelligence in the context of acute neurology.  JAMIA Open  2025 Dec;8(6):ooaf143. pii:ooaf143
  3. Ahmad FS, Wehbe RM, Wilcox JE  The SCAI Is Not the Limit: Refining Dynamic Shock Trajectories With Machine Learning-Based Phenotyping.  JACC Heart Fail  2025 Dec;13(12):102700. doi:10.1016/j.jchf.2025.102700
  4. Gyberg DJ, Komtebedde J, Mylavarapu U, Litwin SE, Leon MB, Cutlip DE, Solomon SD, Starling RC, Cikes M, Borlaug BA  et al.  Refining Atrial Shunt Therapy for HFpEF: Lessons from Pivotal Randomized Trials and Emerging Directions.  J Card Fail  2025 Nov 29;. pii:S1071-9164(25)00436-1
  5. Pandey A, Moroney M, Verma S, Borlaug BA, Butler J, Davies MJ, Kitzman DW, Shah SJ, Petrie MC, Rönnbäck C  et al.  Effects of semaglutide in obesity-related heart failure with preserved ejection fraction across the age spectrum: Findings from the STEP-HFpEF programme.  Eur J Heart Fail  2025 Nov 25;. doi:10.1002/ejhf.70049
  6. Shimano KA, Grimes AB, Kaicker S, Shah SJ, Gunn E, Bhat RV, Kochhar M, Rothman JA, Rose MJ, Briones M  et al.  Eltrombopag for Newly Diagnosed Pediatric Immune Thrombocytopenia Requiring Treatment: The PINES Randomized Clinical Trial.  JAMA  2025 Nov 25;334(20):1816-1826. doi:10.1001/jama.2025.18168
  7. Samadian KD, Chua E, Peng B, Coleska A, Hassan A, Chong P, Locke B, Liebovitz DM, Rohlfsen C, He S  Entropy removal of clinical features.  Sci Rep  2025 Nov 23;. doi:10.1038/s41598-025-29069-0
  8. Ostrominski JW, Harrington J, Claggett BL, Filippatos G, Desai AS, Jhund PS, Henderson AD, Lam CSP, Senni M, Shah SJ  et al.  Anthropometric Measures, Cardiovascular Outcomes, and Treatment Effects of Finerenone in Cardiovascular-Kidney-Metabolic Disease: Pooled Participant-Level Analysis of 3 Global Trials.  J Am Coll Cardiol  2025 Nov 18;86(20):1781-1801. doi:10.1016/j.jacc.2025.08.039
  9. Alexander TJ, Gauen AM, Petito LC, Kohli-Lynch CN, Carton TW, Smith SM, Merritt G, Ahmad FS, Allen NB  Hypertension in Young Adults: Social Determinants of Prevalence, Awareness, Treatment, and Control.  Am J Hypertens  2025 Nov 13;. pii:hpaf203
  10. Ahmad FS, Khan SS, Levin MG  Implementation Intelligence With AI-Prospective Evaluations Needed.  JAMA Cardiol  2025 Nov 10;. doi:10.1001/jamacardio.2025.4668
  11. Fontana M, Garcia-Pavia P, Grogan M, Shah SJ, Engelmann MDM, Hovingh GK, Kristen AV, Lim-Watson M, Malling B, Kar S  et al.  Coramitug, a Humanized Monoclonal Antibody for the Treatment of Transthyretin Amyloid Cardiomyopathy: a Phase 2, Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial.  Circulation  2025 Nov 10;. doi:10.1161/CIRCULATIONAHA.125.077304
  12. Yu S, Fu Y, Wong JH, Wang J, Zhao H, Zhao J, Yue F  The 3D Genome Browser 2.0: an enhanced online platform for visualizing and analyzing 3D genome architecture.  Nucleic Acids Res  2025 Nov 09;. pii:gkaf1109
  13. Inciardi RM, Lu H, Claggett BL, Desai AS, Jhund PS, Henderson AD, Lam CSP, Merkely B, Miao MZ, Senni M  et al.  Finerenone in patients with severe heart failure: The FINEARTS-HF trial.  Eur J Heart Fail  2025 Nov 04;. doi:10.1002/ejhf.70083
  14. Wang H, Schwirtlich T, Houskamp E, Hutch M, Murphy J, Nascimento JSPD, Zini A, Brancaleoni L, Giacomozzi S, Luo Y  et al.  Automated Detection of the Black Hole Sign for Patients with Intracerebral Hemorrhage Using Self-Supervised Learning.  AJNR Am J Neuroradiol  2025 Nov 03;46(11):2300-2309. doi:10.3174/ajnr.A8826
  15. Amagai S, Chaudhari V, Chhikara K, Ingraham NE, Hochberg CH, Barker AK, Mao C, Ortiz AC, Weissman GE, Schmid BE  et al.  The Epidemiology of ICU Readmissions Across Ten Health Systems.  Crit Care Explor  2025 Nov 01;7(11):e1341. pii:e1341
  16. Chang AY, Kaufman JD, Shah SJ, Tan AX, Patel RB, Margolis HG, Psaty BM, Gardin JM, Al-Kindi S, Austin TR  et al.  Cross-Sectional Association of Ground-Level Ozone and Nitrogen Dioxide With Cardiac Mechanics Using Speckle-Tracking Echocardiography in the Cardiovascular Health Study.  Echocardiography  2025 Nov;42(11):e70330. doi:10.1111/echo.70330
  17. Mohr DC  Passive sensing in mental health: Challenges and opportunities.  J Psychopathol Clin Sci  2025 Nov;134(8):1034-1035. doi:10.1037/abn0001058
  18. Lakhtakia T, Smith SR, Meyerhoff J, Meng Y, Ungar LH, Mohr DC, Stamatis CA  Differential associations of passively sensed behaviors with in-vivo depression symptoms.  J Psychopathol Clin Sci  2025 Nov;134(8):860-871. doi:10.1037/abn0001059
  19. Borlaug BA, Kitzman DW, Patel S, Chinnakondepalli KM, Butler J, Davies MJ, Petrie MC, Shah SJ, Verma S, Núñez J  et al.  Semaglutide and Exercise Function in Obesity-Related HFpEF: Insights From the STEP-HFpEF Program.  JACC Heart Fail  2025 Nov;13(11):102660. doi:10.1016/j.jchf.2025.102660
  20. Ige MO, French DD, Chaudhury AS, Li Y, Andrews CA, Kanwar K, Zhou X, Marwah S, Evans CT, Kho AN  et al.  Quality of Care in Patients With Newly Diagnosed Glaucoma.  JAMA Ophthalmol  2025 Nov 01;143(11):893-902. doi:10.1001/jamaophthalmol.2025.2995
  21. Shetty NS, Gaonkar M, Pampana A, Patel N, Carson AP, Haring B, Psaty BM, Kooperberg C, Boerwinkle E, Rotter JI  et al.  Association of Pathogenic/Likely Pathogenic Inherited Cardiomyopathy Variants With Heart Failure: A TOPMed Multiancestry Analysis.  Mayo Clin Proc  2025 Nov;100(11):1948-1955. doi:10.1016/j.mayocp.2025.01.021
  22. Tibrewala A, Pham DT, Hu M, Petito LC, Rich JD, Gustafsson F, de By TMMH, Veen K, Lloyd-Jones DM, Shah SJ  Risk prediction model for waitlist mortality in patients with left ventricular assist devices.  JHLT Open  2025 Nov;10:100337. pii:100337
  23. Fass OZ, Kristinsdottir K, Kaklamanos E, Soni P, Hudson K, Etemadi M, Pandolfino JE, Carlson DA  Improved Performance of an Updated Artificial Intelligence Model for Interpretation of Functional Lumen Imaging Probe Panometry Studies.  Neurogastroenterol Motil  2025 Nov;37(11):e70120. doi:10.1111/nmo.70120
  24. Danziger GS, French DD, Li Y, Andrews CA, Marwah S, Rivera AS, Zhou X, Chaudhury AS, Mohamedali A, Aneja A  et al.  Rates and Associated Risk Factors for Cataract Surgery Complications in Academic Medical Centers.  J Cataract Refract Surg  2025 Oct 31;. doi:10.1097/j.jcrs.0000000000001822
  25. Maznyczka A, Nuis RJ, Shiri I, Ternacle J, Garot P, van den Dorpel MMP, Khokhar AA, De Lucia R, Orini M, Kutty S  et al.  Artificial Intelligence in Valvular Heart Disease: Innovations and Future Directions.  JACC Cardiovasc Interv  2025 Oct 27;18(20):2439-2457. doi:10.1016/j.jcin.2025.08.031
  26. Kruzan KP, Ammerman B, Lengel GJ, Griffith JW, Lucas K, Nguyen T, Rushton K, Washburn JJ, Mohr DC  Development and initial test of an online self-assessment of nonsuicidal self-injury severity.  J Affect Disord  2025 Oct 15;387:119506. doi:10.1016/j.jad.2025.119506
  27. Zelicha H, Weitzner ZN, Park S, Babb TG, Bernhardt V, Ahmad FS, Cella D, Chen Y, Livingston EH  Improvement in breathlessness following bariatric surgery as measured by a new heart failure-specific health-related quality of life instrument: a prospective longitudinal study.  Surg Obes Relat Dis  2025 Oct 10;. pii:S1550-7289(25)00955-4
  28. Li Z, LaPenna KB, Gehred ND, Yu X, Tang WHW, Doiron JE, Xia H, Chen J, Driver IH, Sachse FB  et al.  Dysregulated Protein s-Nitrosylation Promotes Nitrosative Stress and Disease Progression in Heart Failure With Preserved Ejection Fraction.  Circ Res  2025 Oct 10;137(9):1185-1206. doi:10.1161/CIRCRESAHA.124.326042
  29. Kaklamanos E, Kristinsdottir K, Wittbrodt M, Li M, Pitisuttithum P, Kou W, Keswani RN, Carlson D, Etemadi M, Pandolfino JE  From Pixels to Peristalsis: Comparing Achalasia Diagnosis With Artificial Intelligence With Expert Endoscopists.  Clin Gastroenterol Hepatol  2025 Oct 09;. pii:S1542-3565(25)00859-6
  30. Vaduganathan M, Claggett BL, Chatur S, Desai AS, Jhund PS, Vardeny O, Merkely B, Martinez F, Comin-Colet J, Kerr Saraiva JF  et al.  Lifetime benefits of comprehensive medical therapy in heart failure with mildly reduced or preserved ejection fraction.  Nat Med  2025 Oct 06;. doi:10.1038/s41591-025-04037-3
  31. Nateghi R, Zhou R, Saft M, Schnauss M, Neill C, Alam R, Handa N, Huang M, Li EV, Goldstein JA  et al.  Artificial Intelligence (AI)-Driven Screening of Equivocal Prostate Immunohistochemistry (IHC) Cases: Development and Validation of a Screening and Cancer Detection Framework.  Mod Pathol  2025 Oct 01;38(12):100904. doi:10.1016/j.modpat.2025.100904
  32. Patel RB, Shah SJ  Easing the Strain: Atrial Function After Atrial Shunting.  Circ Heart Fail  2025 Oct;18(10):e013583. doi:10.1161/CIRCHEARTFAILURE.125.013583
  33. Pandey A, Kitzman DW, Chinnakondepalli KM, Patel S, Borlaug BA, Butler J, Davies MJ, Shah SJ, Verma S, Rönnbäck C  et al.  Frailty and Effects of Semaglutide in Obesity-Related HFpEF: Findings From the STEP-HFpEF Program.  JACC Heart Fail  2025 Oct;13(10):102610. doi:10.1016/j.jchf.2025.102610
  34. Butt JH, de Boer RA, Docherty KF, Kondo T, Hernandez AF, Inzucchi SE, Kosiborod MN, Køber L, Lam CSP, Martinez FA  et al.  Dapagliflozin, Heart Failure, and Duration of Diabetes: A Patient-Level Pooled Meta-Analysis of DAPA-HF and DELIVER.  JACC Heart Fail  2025 Oct;13(10):102630. doi:10.1016/j.jchf.2025.102630
  35. Lu H, Claggett BL, Vaduganathan M, Desai AS, Jhund PS, Voors AA, Senni M, Zannad F, Pitt B, Shah SJ  et al.  Temporal Changes in Biomarkers, Functional Status, and Quality of Life Prior to Adverse Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction.  JACC Heart Fail  2025 Oct;13(10):102590. doi:10.1016/j.jchf.2025.102590
  36. Chitsazan M, Parekh JK, Kosyakovsky LB, Nemeth SM, Lau ES, Januzzi JL, Wang TJ, Levy D, Ndumele CE, Selvin E  et al.  Natriuretic Peptide Cut Points for Heart Failure Classification in Individuals With and Without Obesity.  Circ Heart Fail  2025 Oct;18(10):e013112. doi:10.1161/CIRCHEARTFAILURE.125.013112
  37. Doiron JE, Elbatreek MH, Xia H, Yu X, Gehred ND, Gromova T, Chen J, Driver IH, Muraoka N, Jensen M  et al.  Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF: Evidence for Synergistic Benefit With GLP-1/Glucagon Agonism.  JACC Basic Transl Sci  2025 Oct;10(10):101297. pii:101297
  38. Khan SS, Harrington RA, Ahmad FS  Blood Pressure Measurement in Retail Stores and Population Health.  JAMA Cardiol  2025 Oct 01;10(10):1049. doi:10.1001/jamacardio.2025.2492
  39. Yaku H, Shah SJ  The Key Role of Diagnostic Imaging in Early HFpEF.  JACC Cardiovasc Imaging  2025 Oct;18(10):1145-1160. doi:10.1016/j.jcmg.2025.05.016
  40. Lefer DJ, Sharp TE, Scarborough AL, Haydel AG, Shah SJ, Li Z, Goodchild TT  Renal denervation improves cardiac function and exercise duration in a miniswine model of heart failure with preserved ejection fraction.  Eur J Heart Fail  2025 Oct;27(10):1853-1856. doi:10.1002/ejhf.3700
  41. Choi J, Gordon A, Eresen A, Zhang Z, Borhani A, Bagci U, Lewandowski R, Kim DH  Current applications of radiomics in the assessment of tumor microenvironment of hepatocellular carcinoma.  Abdom Radiol (NY)  2025 Oct;50(10):4661-4675. doi:10.1007/s00261-025-04916-w
  42. Lei Y, Li Z, Bui Q, DePaul O, Nicol GE, Mohr DC, Fong MWM, Metts CL, Lee SI, Tomazin SE  et al.  Satisfaction, user experiences, and initial efficacy of a technology-supported self-management intervention (iSMART) to improve post-stroke functioning: a remoted randomized controlled trial.  Top Stroke Rehabil  2025 Oct;32(7):677-691. doi:10.1080/10749357.2025.2450950
  43. Zhang B, Wu Q, Jhaveri R, Zhou T, Becich MJ, Bisyuk Y, Blanceró F, Chrischilles EA, Chuang CH, Cowell LG  et al.  Long COVID associated with SARS-CoV-2 reinfection among children and adolescents in the omicron era (RECOVER-EHR): a retrospective cohort study.  Lancet Infect Dis  2025 Sep 30;. pii:S1473-3099(25)00476-1
  44. Elbatreek MH, Li Z, Yu X, Gehred ND, Gromova T, Chen J, Muraoka N, Jensen M, Kartha V, Carrico C  et al.  Low Dose GLP-1 Therapy Attenuates Pathological Cardiac and Hepatic Remodelling in HFpEF Independent of Weight Loss.  bioRxiv  2025 Sep 29;. pii:2025.09.26.678829
  45. Naved BA, Han S, Koss KM, Kando MJ, Wang JJ, Chang J, Weiss C, Passman MG, Wertheim JA, Luo Y  et al.  Revealing gait as a murine biomarker of injury, disease, and age with multivariate statistics and machine learning.  Sci Rep  2025 Sep 29;15(1):33457. pii:33457
  46. Oshinubi K, Chen Y, Doerry E, Gel ES, Hepp C, Lant T, Mehrotra S, Sabo S, Mihaljevic J  A Systematic Review of Spatial Epidemiological Modeling Approaches Applied During the COVID-19 Pandemic.  medRxiv  2025 Sep 25;. pii:2025.09.24.25336493
  47. Donnelly JM, Neff RA, Sedlack AJH, Juska VB, Ayala-Cardona LF, Bass J, McNally EM, Shah SJ, Alshurafa N, Kimchi EY  et al.  From reactive to proactive: Continuous protein monitoring for preventive health care.  Science  2025 Sep 25;389(6767):eady6497. doi:10.1126/science.ady6497
  48. Wang Z, Cao L, Jin Q, Chan J, Wan N, Afzali B, Cho HJ, Choi CI, Emamverdi M, Gill MK  et al.  A foundation model for human-AI collaboration in medical literature mining.  Nat Commun  2025 Sep 24;16(1):8361. pii:8361
  49. Marrero N, Jha K, Grant J, Razavi AC, Budoff MJ, Shah SJ, Rotter JI, Blumenthal RS, Post WS, Shaw LJ  et al.  Impact of Age on Aortic Valve Calcium Progression and Risk for Aortic Stenosis: Multi-Ethnic Study of Atherosclerosis.  Eur Heart J Cardiovasc Imaging  2025 Sep 23;. pii:jeaf279
  50. Pour-Rashidi A, Zandpazandi S, Perronne L, Hill VB, Krumpelman C, Subedi K, Kelahan L, Borhani AA, Savas H, Avery R  et al.  Intracranial Metastases from Uterine Leiomyosarcoma: A Systematic Review and Case Illustration.  J Clin Med  2025 Sep 20;14(18). pii:6631

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