Research

Research Overview
Publications

Publications

Browse the list below to see the latest scientific publications stemming from our center faculty’s work. To view publications of specific AI faculty, please visit Membership and select a profile link.

Fudim M, Fail PS, Litwin SE, Shaburishvili T, Goyal P, Hummel S, Borlaug BA, Mohan RC, Patel RB, Mitter SS et al. Endovascular Ablation of the Right Greater Splanchnic Nerve in Heart Failure with Preserved Ejection Fraction: Early Results of the REBALANCE-HF Trial Roll-in Cohort. Eur J Heart Fail 2022 May 22;. doi:10.1002/ejhf.2559
Namjou B, Lape M, Malolepsza E, DeVore SB, Weirauch MT, Dikilitas O, Jarvik GP, Kiryluk K, Kullo IJ, Liu C et al. Multiancestral polygenic risk score for pediatric asthma. J Allergy Clin Immunol 2022 May 17;. pii:S0091-6749(22)00660-1
Feng YA, Stanaway IB, Connolly JJ, Denny JC, Luo Y, Weng C, Wei WQ, Weiss ST, Karlson EW, Smoller JW Psychiatric manifestations of rare variation in medically actionable genes: a PheWAS approach. BMC Genomics 2022 May 19;23(1):385. doi:10.1186/s12864-022-08600-x
Zhao Y, Yu Y, Wang H, Li Y, Deng Y, Jiang G, Luo Y Machine Learning in Causal Inference: Application in Pharmacovigilance. Drug Saf 2022 May;45(5):459-476. doi:10.1007/s40264-022-01155-6
Amgad M, Atteya LA, Hussein H, Mohammed KH, Hafiz E, Elsebaie MAT, Alhusseiny AM, AlMoslemany MA, Elmatboly AM, Pappalardo PA et al. NuCLS: A scalable crowdsourcing approach and dataset for nucleus classification and segmentation in breast cancer. Gigascience 2022 May 17;11. pii:giac037
Musa J, Kim K, Zheng Y, Qu Y, Joyce BT, Wang J, Nannini DR, Gursel DB, Silas O, Abdulkareem FB et al. Accelerated Epigenetic Age Among Women with Invasive Cervical Cancer and HIV-Infection in Nigeria. Front Public Health 2022;10:834800. doi:10.3389/fpubh.2022.834800
Mahajan A, Spracklen CN, Zhang W, Ng MCY, Petty LE, Kitajima H, Yu GZ, Rüeger S, Speidel L, Kim YJ et al. Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation. Nat Genet 2022 May;54(5):560-572. doi:10.1038/s41588-022-01058-3
Bui Q, Kaufman KJ, Munsell EG, Lenze EJ, Lee JM, Mohr DC, Fong MW, Metts CL, Tomazin SE, Pham V et al. Smartphone assessment uncovers real-time relationships between depressed mood and daily functional behaviors after stroke. J Telemed Telecare 2022 May 13;:1357633X221100061. doi:10.1177/1357633X221100061
Sun F, Ou J, Shoffner AR, Luan Y, Yang H, Song L, Safi A, Cao J, Yue F, Crawford GE et al. Enhancer selection dictates gene expression responses in remote organs during tissue regeneration. Nat Cell Biol 2022 May;24(5):685-696. doi:10.1038/s41556-022-00906-y
Mo X, Niu Q, Ivanov AA, Tsang YH, Tang C, Shu C, Li Q, Qian K, Wahafu A, Doyle SP et al. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. Cell 2022 Apr 27;. pii:S0092-8674(22)00461-5
Jering KS, Campagnari C, Claggett B, Adler E, Klein L, Ahmad FS, Voors AA, Solomon S, Yagil A, Greenberg B Improving clinical trial efficiency using a machine learning-based risk score to enrich study populations. Eur J Heart Fail 2022 May 04;. doi:10.1002/ejhf.2528
Richardson JE, Rasmussen LV, Dorr DA, Sirkin JT, Shelley D, Rivera A, Wu W, Cykert S, Cohen DJ, Kho AN Generating and Reporting Electronic Clinical Quality Measures from Electronic Health Records: Strategies from EvidenceNOW Cooperatives. Appl Clin Inform 2022 03;13(2):485-494. doi:10.1055/s-0042-1748145
Iorga M, Drakopoulos M, Naidech AM, Katsaggelos AK, Parrish TB, Hill VB Labeling Noncontrast Head CT Reports for Common Findings Using Natural Language Processing. AJNR Am J Neuroradiol 2022 May;43(5):721-726. doi:10.3174/ajnr.A7500
Chuzi S, Ahmad FS, Wu T, Argaw S, Harap R, Grady KL, Rich JD, Pham DT, Khan SS, Wilcox JE et al. Time Spent Engaging in Health Care Among Patients With Left Ventricular Assist Devices. JACC Heart Fail 2022 May;10(5):321-332. pii:S2213-1779(22)00076-2
Huston JH, Shah SJ Understanding the Pathobiology of Pulmonary Hypertension Due to Left Heart Disease. Circ Res 2022 Apr 29;130(9):1382-1403. doi:10.1161/CIRCRESAHA.122.319967
Adler DA, Wang F, Mohr DC, Choudhury T Machine learning for passive mental health symptom prediction: Generalization across different longitudinal mobile sensing studies. PLoS One 2022;17(4):e0266516. doi:10.1371/journal.pone.0266516
Li Y, Liu Q, Zeng Z, Luo Y Using an Unsupervised Clustering Model to Detect the Early Spread of SARS-CoV-2 Worldwide. Genes (Basel) 2022 04 07;13(4). pii:648
Zeng C, Bastarache LA, Tao R, Venner E, Hebbring S, Andujar JD, Bland ST, Crosslin DR, Pratap S, Cooley A et al. Association of Pathogenic Variants in Hereditary Cancer Genes With Multiple Diseases. JAMA Oncol 2022 Apr 21;. doi:10.1001/jamaoncol.2022.0373
Burstein DS, Svigos F, Patel A, Reddy NK, Michelson KN, O'Dwyer LC, Linzer M, Linder JA, Victorson D A Scoping Review on the Concept of Physician Caring. J Gen Intern Med 2022 Apr 07;. doi:10.1007/s11606-021-07382-4
Ayer A, Banerjee U, Mills C, Donovan C, Nelson L, Shah SJ, Dubin RF Left atrial strain is associated with adverse cardiovascular events in patients with end-stage renal disease: Findings from the Cardiac, Endothelial Function and Arterial Stiffness in ESRD (CERES) study. Hemodial Int 2022 Apr 06;. doi:10.1111/hdi.13008
Hughes ZH, Ning H, Shah SJ, Yancy CW, Wilkins JT, Lloyd-Jones DM, Khan SS, Shah NS Distribution of 10- and 30-Year Predicted Risks for Heart Failure in the US Population: National Health and Nutrition Examination Surveys 2015 to 2018. Circ Heart Fail 2022 May;15(5):e009351. doi:10.1161/CIRCHEARTFAILURE.121.009351
Borlaug BA, Blair J, Bergmann MW, Bugger H, Burkhoff D, Bruch L, Celermajer DS, Claggett B, Cleland JGF, Cutlip DE et al. Latent Pulmonary Vascular Disease May Alter the Response to Therapeutic Atrial Shunt Device in Heart Failure. Circulation 2022 May 24;145(21):1592-1604. doi:10.1161/CIRCULATIONAHA.122.059486
Ahmad FS, Luo Y, Wehbe RM, Thomas JD, Shah SJ Advances in Machine Learning Approaches to Heart Failure with Preserved Ejection Fraction. Heart Fail Clin 2022 Apr;18(2):287-300. pii:S1551-7136(21)00117-3
Zeng Z, Li Y, Li Y, Luo Y Statistical and machine learning methods for spatially resolved transcriptomics data analysis. Genome Biol 2022 03 25;23(1):83. doi:10.1186/s13059-022-02653-7
Patel RB, Shah SJ Inclusion Criteria for Heart Failure With Preserved Ejection Fraction Clinical Trials: Making the Case for Precision Diagnosis and Greater Inclusivity. J Card Fail 2022 May;28(5):732-735. pii:S1071-9164(22)00450-X
Schantz K, Gordon EJ, Lee U, Rocha M, Friedewald J, Ladner DP, Becker Y, Formica R, Reese PP, Kaufman D et al. The Role of Procurement Biopsies in Kidney Acceptance Decision Making and Kidney Discard: Perceptions of Physicians, Nurse Coordinators, and OPO Staff and Directors. Transplant Direct 2022 Apr;8(4):e1299. doi:10.1097/TXD.0000000000001299
Shah SJ BNP: Biomarker Not Perfect in heart failure with preserved ejection fraction. Eur Heart J 2022 May 21;43(20):1952-1954. doi:10.1093/eurheartj/ehac121
Bui Q, Kaufman KJ, Pham V, Lenze EJ, Lee JM, Mohr DC, Fong MWM, Metts CL, Tomazin SE, Wong AWK Ecological Momentary Assessment of Real-World Functional Behaviors in Individuals With Stroke: A Longitudinal Observational Study. Arch Phys Med Rehabil 2022 Mar 09;. pii:S0003-9993(22)00267-2
Mazumder NR, Kazen A, Carek A, Etemadi M, Levitsky J The answer at our fingertips: Volume status in cirrhosis determined by machine learning and pulse oximeter waveform. Physiol Rep 2022 03;10(5):e15223. doi:10.14814/phy2.15223
Shabani M, Dutta D, Ambale-Venkatesh B, Post WS, Taylor KD, Rich SS, Wu CO, Pereira NL, Shah SJ, Chatterjee N et al. Rare Genetic Variants Associated With Myocardial Fibrosis: Multi-Ethnic Study of Atherosclerosis. Front Cardiovasc Med 2022;9:804788. doi:10.3389/fcvm.2022.804788
Smith SM, Desai RA, Walsh MG, Nilles EK, Shaw K, Smith M, Chamberlain AM, Derington CG, Bress AP, Chuang CH et al. Angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and COVID-19-related outcomes: A patient-level analysis of the PCORnet blood pressure control lab. Am Heart J Plus 2022 Jan;13:100112. doi:10.1016/j.ahjo.2022.100112
Wang MC, Dolan B, Freed BH, Vega L, Markoski N, Wainright AE, Kane B, Seegmiller LE, Harrington K, Lewis AA et al. Corrigendum: Rationale and Design of a Pharmacist-led Intervention for the Risk-Based Prevention of Heart Failure: The FIT-HF Pilot Study. Front Cardiovasc Med 2022;9:844270. doi:10.3389/fcvm.2022.844270
Hophan SL, Odnokoz O, Liu H, Luo Y, Khan S, Gradishar W, Zhou Z, Badve S, Torres MA, Wan Y Ductal Carcinoma In Situ of Breast: From Molecular Etiology to Therapeutic Management. Endocrinology 2022 04 01;163(4). pii:bqac027
Solomon SD, Vaduganathan M, Claggett BL, de Boer RA, DeMets D, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F et al. Baseline Characteristics of Patients With HF With Mildly Reduced and Preserved Ejection Fraction: DELIVER Trial. JACC Heart Fail 2022 03;10(3):184-197. pii:S2213-1779(21)00583-7
Adler DA, Wang F, Mohr DC, Estrin D, Livesey C, Choudhury T A call for open data to develop mental health digital biomarkers. BJPsych Open 2022 Mar 03;8(2):e58. doi:10.1192/bjo.2022.28
Michelson KN, Adams JG, Faber JMM Navigating Clinical and Business Ethics While Sharing Patient Data. JAMA 2022 Mar 15;327(11):1025-1026. doi:10.1001/jama.2022.1942
Wei X, Xiang Y, Peters DT, Marius C, Sun T, Shan R, Ou J, Lin X, Yue F, Li W et al. HiCAR is a robust and sensitive method to analyze open-chromatin-associated genome organization. Mol Cell 2022 03 17;82(6):1225-1238.e6. pii:S1097-2765(22)00098-3
Goulding EH, Dopke CA, Rossom RC, Michaels T, Martin CR, Ryan C, Jonathan G, McBride A, Babington P, Bernstein M et al. A Smartphone-Based Self-management Intervention for Individuals With Bipolar Disorder (LiveWell): Empirical and Theoretical Framework, Intervention Design, and Study Protocol for a Randomized Controlled Trial. JMIR Res Protoc 2022 Feb 21;11(2):e30710. doi:10.2196/30710
Bavishi A, Colangelo LA, Rasmussen-Torvik LJ, Lima JAC, Nannini DR, Vaduganathan M, Pandey A, Lloyd-Jones DM, Shah SJ, Patel RB Genetic variation in sodium glucose co-transporter 1 and cardiac structure and function at middle age. ESC Heart Fail 2022 04;9(2):1496-1501. doi:10.1002/ehf2.13841
Arrieta VA, Chen AX, Kane JR, Kang SJ, Kassab C, Dmello C, Zhao J, Burdett KB, Upadhyayula PS, Lee-Chang C et al. Publisher Correction: ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma. Nat Cancer 2022 Mar;3(3):373. doi:10.1038/s43018-022-00343-8
Contaxis N, Clark J, Dellureficio A, Gonzales S, Mannheimer S, Oxley PR, Ratajeski MA, Surkis A, Yarnell AM, Yee M et al. Ten simple rules for improving research data discovery. PLoS Comput Biol 2022 02;18(2):e1009768. doi:10.1371/journal.pcbi.1009768
Arrieta VA, Chen AX, Kane JR, Kang SJ, Kassab C, Dmello C, Zhao J, Burdett KB, Upadhyayula PS, Lee-Chang C et al. ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma. Nat Cancer 2021 Dec;2(12):1372-1386. doi:10.1038/s43018-021-00260-2
Shah SJ, Borlaug BA, Chung ES, Cutlip DE, Debonnaire P, Fail PS, Gao Q, Hasenfuß G, Kahwash R, Kaye DM et al. Atrial shunt device for heart failure with preserved and mildly reduced ejection fraction (REDUCE LAP-HF II): a randomised, multicentre, blinded, sham-controlled trial. Lancet 2022 03 19;399(10330):1130-1140. pii:S0140-6736(22)00016-2
Yang H, Zhang H, Luan Y, Liu T, Yang W, Roberts KG, Qian MX, Zhang B, Yang W, Perez-Andreu V et al. Noncoding genetic variation in GATA3 increases acute lymphoblastic leukemia risk through local and global changes in chromatin conformation. Nat Genet 2022 02;54(2):170-179. doi:10.1038/s41588-021-00993-x
Kou W, Carlson DA, Baumann AJ, Donnan EN, Schauer JM, Etemadi M, Pandolfino JE A multi-stage machine learning model for diagnosis of esophageal manometry. Artif Intell Med 2022 02;124:102233. pii:S0933-3657(21)00226-8
Mao C, Yao L, Luo Y MedGCN: Medication recommendation and lab test imputation via graph convolutional networks. J Biomed Inform 2022 03;127:104000. pii:S1532-0464(22)00016-8
Yu J, Pacheco JA, Ghosh AS, Luo Y, Weng C, Shang N, Benoit B, Carrell DS, Carroll RJ, Dikilitas O et al. Under-specification as the source of ambiguity and vagueness in narrative phenotype algorithm definitions. BMC Med Inform Decis Mak 2022 01 28;22(1):23. doi:10.1186/s12911-022-01759-z
Luo Y, Wunderink RG, Lloyd-Jones D Proactive vs Reactive Machine Learning in Health Care: Lessons From the COVID-19 Pandemic. JAMA 2022 02 15;327(7):623-624. doi:10.1001/jama.2021.24935
Min J, Putt ME, Yang W, Bertoni AG, Ding J, Lima JAC, Allison MA, Barr RG, Al-Naamani N, Patel RB et al. Association of Pericardial Fat with Cardiac Structure, Function, and Mechanics: The Multi-Ethnic Study of Atherosclerosis. J Am Soc Echocardiogr 2022 Jan 19;. pii:S0894-7317(22)00007-4
Chandramouli C, Ting TW, Tromp J, Agarwal A, Svedlund S, Saraste A, Hage C, Tan RS, Beussink-Nelson L, Lagerström Fermer M et al. Sex differences in proteomic correlates of coronary microvascular dysfunction among patients with heart failure and preserved ejection fraction. Eur J Heart Fail 2022 Apr;24(4):681-684. doi:10.1002/ejhf.2435