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Northwestern University Feinberg School of Medicine
Institute for Artificial Intelligence in Medicine

Publications

Browse the list below to see the latest scientific publications stemming from our institute faculty’s work. To view publications of specific AI faculty, please visit Membership and select a profile link.

  1. Tibrewala A, Pham DT, Hu M, Petito LC, Rich JD, Gustafsson F, de By TMMH, Veen K, Lloyd-Jones DM, Shah SJ  Risk prediction model for waitlist mortality in patients with left ventricular assist devices.  JHLT Open  2025 Nov;10:100337. pii:100337
  2. Kruzan KP, Ammerman B, Lengel GJ, Griffith JW, Lucas K, Nguyen T, Rushton K, Washburn JJ, Mohr DC  Development and initial test of an online self-assessment of nonsuicidal self-injury severity.  J Affect Disord  2025 Oct 15;387:119506. doi:10.1016/j.jad.2025.119506
  3. Ostrominski JW, Filippatos G, Claggett BL, Miao ZM, Desai AS, Jhund PS, Henderson A, Rohwedder K, Brinker MD, Scalise A  et al.  Effect of Finerenone on Morbidity and Mortality in CKD.  J Am Soc Nephrol  2025 Sep 12;. doi:10.1681/ASN.0000000823
  4. Huang X, Hughes Z, Fonarow GC, Ahmad FS, Shah NS, Chuzi S, Kershaw KN, Greenland P, Khan SS, Petito LC  Racial and Ethnic Differences in Patient Age at First Hospitalization for Heart Failure.  J Am Coll Cardiol  2025 Sep 09;86(10):711-720. doi:10.1016/j.jacc.2025.06.046
  5. Jain SS, Mortazavi BJ, Chan You S, Yao X, Lam CSP, Elias P, Poterucha TJ, Avram R, Tison GH, Pirruccello J  et al.  Moving Beyond the Model: Our Perspective on Meaningful AI Research in Cardiovascular Care.  J Am Coll Cardiol  2025 Sep 09;86(10):691-695. doi:10.1016/j.jacc.2025.07.040
  6. Ostrominski JW, Claggett BL, Desai AS, Jhund PS, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F, Pitt B  et al.  Finerenone according to insulin resistance in heart failure: Insights from the FINEARTS-HF trial.  Eur J Heart Fail  2025 Sep 08;. doi:10.1002/ejhf.70034
  7. Bene-Alhasan Y, Bartz TM, Djoussé L, Ix J, Siscovick D, Gottdiener JS, Tracy RP, Hirsch CH, Newman AB, Shah SJ  et al.  Advanced Glycation End-Product Carboxymethyl-Lysine and Incident Heart Failure and Atrial Fibrillation in Older Adults.  J Am Heart Assoc  2025 Sep 05;:e040640. doi:10.1161/JAHA.124.040640
  8. Hensley CP, Kho AN, Kritselis A, Song J, Lee J, Chang AH  Preoperative Factors Associated With Falls Following Total Hip Arthroplasty in Older Adults.  ACR Open Rheumatol  2025 Sep;7(9):e70091. pii:e70091
  9. Zhang P, Mao C, Sun A, Yang Y, Hou Y, Fu Z, Babak T, Leverenz JB, Pieper AA, Luo Y  et al.  Real-world observations of GLP-1 receptor agonists and SGLT-2 inhibitors as potential treatments for Alzheimer's disease.  Alzheimers Dement  2025 Sep;21(9):e70639. pii:e70639
  10. Chaudhary RS, Hussain SMD, Wang YS, Komtebedde J, Hasenfuß G, Borlaug BA, Kaye DM, Cleland JGF, Leon MB, Shah SJ  et al.  Expanded Definition of Worsening Heart Failure: Impact on Clinical Outcomes and Quality-of-Life Assessment.  JACC Heart Fail  2025 Sep;13(9):102571. doi:10.1016/j.jchf.2025.102571
  11. Yaku H, Sauer AJ, Patel S, O'Keefe EL, Borlaug BA, Kitzman DW, Windsor SL, Khumri T, Umpierrez G, Kosiborod MN  et al.  Orthostatic Pulse Pressure as a Potential Indicator of Preload Insufficiency in HFpEF: Insights From PRESERVED-HF.  JACC Heart Fail  2025 Sep;13(9):102566. doi:10.1016/j.jchf.2025.102566
  12. Luo Y, Fraser L, Jezykowski J, Gupta NA, Miethke AG, Taylor SA, Alonso EM, Horslen S, Kohli R, Molleston JP  et al.  Interleukin 8-CXCR2-mediated neutrophil extracellular trap formation in biliary atresia associated with neutrophil extracellular trap-induced stellate cell activation.  Hepatology  2025 Sep 01;82(3):552-565. doi:10.1097/HEP.0000000000001195
  13. Butt JH, de Boer RA, Docherty KF, Kondo T, Hernandez AF, Inzucchi SE, Kosiborod MN, Køber L, Lam CSP, Martinez FA  et al.  Dapagliflozin, Heart Failure, and Duration of Diabetes: A Patient-Level Pooled Meta-Analysis of DAPA-HF and DELIVER.  JACC Heart Fail  2025 Aug 29;13(10):102630. doi:10.1016/j.jchf.2025.102630
  14. Crum Y, van Veldhuisen DJ, Shah SJ, Mylavarapu U, Hu M, Komtebedde J, Lobeek M, Hoendermis ES, Litwin SE, Solomon SD  et al.  Epicardial adipose tissue, functional status and invasive hemodynamics in heart failure with preserved ejection fraction.  JACC Adv  2025 Aug 26;:102185. doi:10.1016/j.jacadv.2025.102185
  15. Lu H, Claggett BL, Vaduganathan M, Desai AS, Jhund PS, Voors AA, Senni M, Zannad F, Pitt B, Shah SJ  et al.  Temporal Changes in Biomarkers, Functional Status, and Quality of Life Prior to Adverse Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction.  JACC Heart Fail  2025 Aug 25;13(10):102590. doi:10.1016/j.jchf.2025.102590
  16. Shetty NS, Gaonkar M, Pampana A, Patel N, Carson AP, Haring B, Psaty BM, Kooperberg C, Boerwinkle E, Rotter JI  et al.  Association of Pathogenic/Likely Pathogenic Inherited Cardiomyopathy Variants With Heart Failure: A TOPMed Multiancestry Analysis.  Mayo Clin Proc  2025 Aug 22;. pii:S0025-6196(25)00095-3
  17. Ostrominski JW, Harrington J, Claggett BL, Filippatos G, Desai AS, Jhund PS, Henderson AD, Lam CSP, Senni M, Shah SJ  et al.  Anthropometric Measures, Cardiovascular Outcomes, and Treatment Effects of Finerenone in Cardiovascular-Kidney-Metabolic Disease: Pooled Participant-Level Analysis of Three Global Trials.  J Am Coll Cardiol  2025 Aug 20;. pii:S0735-1097(25)07505-9
  18. Tavakoli N, Rahsepar AA, Benefield BC, Shen D, López-Tapia S, Schiffers F, Goldberger JJ, Albert CM, Wu E, Katsaggelos AK  et al.  ScarNet: A Novel Foundation Model for Automated Myocardial Scar Quantification from Late Gadolinium-Enhancement Images.  J Cardiovasc Magn Reson  2025 Aug 20;:101945. doi:10.1016/j.jocmr.2025.101945
  19. Greene CA, Hampton G, Jaworski J, Shuey MM, Khan A, Luo Y, Jarvik GP, Namjou-Khales B, Edwards TL, Velez Edwards DR  et al.  Multi-ancestry meta-analysis of keloids uncovers novel susceptibility loci in diverse populations.  Nat Commun  2025 Aug 20;16(1):7770. pii:7770
  20. Chitsazan M, Parekh JK, Kosyakovsky LB, Nemeth SM, Lau ES, Januzzi JL, Wang TJ, Levy D, Ndumele CE, Selvin E  et al.  Natriuretic Peptide Cut Points for Heart Failure Classification in Individuals With and Without Obesity.  Circ Heart Fail  2025 Aug 20;:e013112. doi:10.1161/CIRCHEARTFAILURE.125.013112
  21. Hoffmann AD, Almubarak HF, Iyer R, Weinberg SE, Squires JR, Mao C, Wei J, Chaudhuri S, El-Shennawy L, Dashzeveg NK  et al.  Identification of immune signatures associated with both SARS-CoV-2 infection and lung transplantation.  Cell Rep Med  2025 Aug 19;6(8):102262. pii:102262
  22. Xian S, Grabowska ME, Kullo IJ, Luo Y, Smoller JW, Walunas TL, Wei WQ, Jarvik GP, Mooney SD, Crosslin DR  Transformer patient embedding using electronic health records enables patient stratification and progression analysis.  NPJ Digit Med  2025 Aug 14;8(1):521. pii:521
  23. Cai FY, Mao C, Luo Y  Constrained Tensor Factorization for Cancer Phenotyping and Mortality Prediction.  Stud Health Technol Inform  2025 Aug 07;329:871-875. doi:10.3233/SHTI250964
  24. Khan SS, Harrington RA, Ahmad FS  Blood Pressure Measurement in Retail Stores and Population Health.  JAMA Cardiol  2025 Aug 06;. doi:10.1001/jamacardio.2025.2492
  25. Vaduganathan M, Claggett BL, Udell JA, Desai AS, Jhund PS, Henderson AD, Lay-Flurrie J, Amarante F, Glasauer A, Lam CSP  et al.  Blinded Withdrawal of Finerenone After Long-Term Treatment in the FINEARTS-HF Trial.  J Am Coll Cardiol  2025 Aug 05;86(5):396-399. doi:10.1016/j.jacc.2025.05.038
  26. Wang MC, Dolan B, Huang X, Freaney PM, Freed BH, Vega L, Markoski N, Wainright A, Kane B, Seegmiller LE  et al.  Feasibility of the Implementation of Tools for Heart Failure Risk Prediction: A Randomized Controlled Pilot Trial.  JACC Adv  2025 Aug;4(8):102004. pii:102004
  27. Luo Z, Xia M, Shi W, Zhao C, Wang J, Xin D, Dong X, Xiong Y, Zhang F, Berry K  et al.  Retraction Note: Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis.  Nature  2025 Aug;644(8075):290. doi:10.1038/s41586-025-09015-w
  28. Hourmozdi J, Easton N, Benigeri S, Thomas JD, Narang A, Ouyang D, Duffy G, Upton R, Hawkes W, Akerman A  et al.  Evaluating the Performance and Potential Bias of Predictive Models for Detection of Transthyretin Cardiac Amyloidosis.  JACC Adv  2025 Aug;4(8):101901. pii:101901
  29. Ding Y, He B, Bogush D, Schramm J, Singh C, Dovat K, Randazzo J, Tukaramrao D, Hengst J, Annageldiyev C  et al.  Critical roles of IKAROS and HDAC1 in regulation of heterochromatin and tumor suppression in T-cell acute lymphoblastic leukemia.  Leukemia  2025 Aug;39(8):2010-2020. doi:10.1038/s41375-025-02651-1
  30. Klein L, Fudim M, Etemadi M, Gordon R, Tibrewala A, Hernandez-Montfort J, McCann P, Zier L, Shah K, Rollins A  et al.  Noninvasive Pulmonary Capillary Wedge Pressure Estimation in Heart Failure Patients With the Use of Wearable Sensing and AI.  JACC Heart Fail  2025 Aug;13(8):102513. doi:10.1016/j.jchf.2025.102513
  31. Butt JH, Jhund PS, Henderson AD, Claggett BL, Chiang CE, Linssen GCM, Saldarriaga CI, Saraiva JFK, Sato N, Schou M  et al.  Finerenone According to Frailty in Heart Failure: A Prespecified Analysis of the FINEARTS-HF Randomized Clinical Trial.  JAMA Cardiol  2025 Aug 01;10(8):829-840. doi:10.1001/jamacardio.2025.1775
  32. Ostrominski JW, Filippatos G, Claggett BL, Miao ZM, Desai AS, Jhund PS, D Henderson A, Scheerer MF, Rohwedder K, Amarante F  et al.  Efficacy and Safety of Finerenone in Heart Failure With Preserved Ejection Fraction: A FINE-HEART Analysis.  JACC Heart Fail  2025 Aug;13(8):102497. doi:10.1016/j.jchf.2025.03.041
  33. Ozyoruk KB, Harmon SA, Yilmaz EC, Gelikman DG, Bagci U, Simon BD, Merino MJ, Lis R, Gurram S, Wood BJ  et al.  Impact of AI-Generated ADC Maps on Computer-Aided Diagnosis of Prostate Cancer: A Feasibility Study.  Acad Radiol  2025 Aug;32(8):4621-4630. doi:10.1016/j.acra.2025.05.041
  34. Agha E, Sutter C, Ojewuyi I, Abramsohn EM, Andriano M, Bell C, Calix AL, Cherry JL, Downing K, Flower T  et al.  The Grief Navigation Trial: A multi-site pragmatic comparative effectiveness trial of two interventions to support parents after their child's unexpected or traumatic death.  Contemp Clin Trials  2025 Aug;155:107962. doi:10.1016/j.cct.2025.107962
  35. Masri A, Aras M, Grogan M, Jacoby D, Maurer MS, Shah SJ, Witteles R, Wong PW, Ji AX, DU J  et al.  Acoramidis for Transthyretin Amyloid Cardiomyopathy: Open-Label Extension Study Long-Term Follow-Up.  J Card Fail  2025 Aug;31(8):1354-1359. doi:10.1016/j.cardfail.2025.03.017
  36. Khan A, Gould PA, Luo Y, Prens EP, Wheless L, Hung AM, , Drivas TG, Ritchie MD, Saeidian AH  et al.  The polygenic architecture of hidradenitis suppurativa reveals signaling mechanisms that implicate epithelial remodeling.  medRxiv  2025 Jul 28;. pii:2025.07.25.25332168
  37. Huerta-Chagoya A, Kim J, Mandla R, Lu Y, Suzuki K, Petty LE, Ng HK, Choi J, Lee S, Rout M  et al.  Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries.  medRxiv  2025 Jul 23;. pii:2025.07.21.25331778
  38. Yaku H, Shah SJ  The Key Role of Diagnostic Imaging in Early HFpEF.  JACC Cardiovasc Imaging  2025 Jul 17;. pii:S1936-878X(25)00306-7
  39. Prasad D, Khandeshi A, Sartin S, Jain R, Dahdaleh N, Lesniak M, Luo Y, Ahuja C  Will AI become our Co-PI?  NPJ Digit Med  2025 Jul 14;8(1):440. pii:440
  40. Fass OZ, Kristinsdottir K, Kaklamanos E, Soni P, Hudson K, Etemadi M, Pandolfino JE, Carlson DA  Improved Performance of an Updated Artificial Intelligence Model for Interpretation of Functional Lumen Imaging Probe Panometry Studies.  Neurogastroenterol Motil  2025 Jul 13;:e70120. doi:10.1111/nmo.70120
  41. Wang X, Li Y, Lin Z, Pla I, Gajjela R, Mattamana BB, Joshi M, Liu Y, Wang H, Zun AB  et al.  Microtopography-induced changes in cell nucleus morphology enhance bone regeneration by modulating the cellular secretome.  Nat Commun  2025 Jul 11;16(1):6444. pii:6444
  42. Rosenthal EA, Wei WQ, Luo Y, Namjou-Khales B, Schaid DJ, Esplin ED, Lape M, Kottyan L, Pacheco JA, Weng C  et al.  Phenome-wide association study identifies multiple traits associated with a polygenic risk score for colorectal cancer.  Hum Genomics  2025 Jul 09;19(1):77. pii:77
  43. Mithal LB, Becker ME, Ling-Hu T, Goo YA, Otero S, Kremer A, Pandey S, Lancki N, Li Y, Luo Y  et al.  Cord blood proteomics identifies biomarkers of early-onset neonatal sepsis.  JCI Insight  2025 Jul 08;10(13). pii:e193826
  44. Yaku H, Burkhoff D, Borlaug BA, Lala A, Butler J, Rich S, Shah SJ  Oral Levosimendan for the Treatment of Pulmonary Hypertension due to Heart Failure With Preserved Ejection Fraction: Rationale and Design of the LEVEL Trial.  J Card Fail  2025 Jul 07;. pii:S1071-9164(25)00293-3
  45. Yaku H, Eicher JC, Bergmann MW, Kister T, Pörner TC, Borlaug BA, Mohan RC, Price M, Komtebedde J, Shah SJ  Management of Flow Reversal in Patients With Atrial Shunts Implanted to Reduce Left Atrial Pressure.  JACC Case Rep  2025 Jul 02;30(17):103893. doi:10.1016/j.jaccas.2025.103893
  46. Naved BA, Ravishankar S, Colbert GE, Johnston A, Slott QM, Luo Y  LLM enabled classification of patient self-reported symptoms and needs in health systems across the USA.  NPJ Digit Med  2025 Jul 01;8(1):390. pii:390
  47. Pabon MA, Vardeny O, Vaduganathan M, Desai AS, Claggett BL, Kulac IJ, Jhund PS, Lam CSP, Senni M, Shah SJ  et al.  Finerenone in Heart Failure With Improved Ejection Fraction: The FINEARTS-HF Randomized Clinical Trial.  JAMA Cardiol  2025 Jul 01;10(7):740-745. doi:10.1001/jamacardio.2025.1101
  48. Barrett MA, Allen A, Vuong VT, Zhu D, Rainey AJ, McConnell WM, Kho AN, Salisbury A, French DD  Impact of an Artificial Intelligence and Machine Learning Enhanced Electronic Health Record System on Quality Measures in Nursing Homes: A Difference-in-Differences Analysis.  J Am Med Dir Assoc  2025 Jul;26(7):105680. doi:10.1016/j.jamda.2025.105680
  49. Butt JH, Jhund PS, Henderson AD, Claggett BL, Desai AS, Lam CSP, Brinker M, Schloemer P, Viswanathan P, Lage A  et al.  Finerenone, glycaemic status, and heart failure with mildly reduced or preserved ejection fraction: A prespecified analysis of the FINEARTS-HF trial.  Eur J Heart Fail  2025 Jul;27(7):1326-1341. doi:10.1002/ejhf.3649
  50. Dennis S, Tsukioki T, Kocherginsky M, Qi AK, DeHorn S, Gurley M, Wrubel E, Luo Y, Khan SA  Neoadjuvant Chemotherapy Response and Genetic Susceptibility in Recently Parous Women with Breast Cancer: A Retrospective Analysis.  Ann Surg Oncol  2025 Jul;32(7):4855-4864. doi:10.1245/s10434-025-17204-0

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