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Northwestern University Feinberg School of Medicine
Institute for Artificial Intelligence in Medicine

Publications

Browse the list below to see the latest scientific publications stemming from our institute faculty’s work. To view publications of specific AI faculty, please visit Membership and select a profile link.

  1. Wang K, Wang J, Weiss MJ, Yue F, Xu J  Disrupting epigenetic insulation underlies CRISPR therapy for β-hemoglobinopathies.  Mol Ther  2025 Dec 22;. pii:S1525-0016(25)01039-1
  2. Banker M, do Nascimento JSP, Shownkeen H, Chang TR, Goldenberg F, Faine B, Cella D, Schuele SU, Luo Y, Tipton E  et al.  Prophylactic Antiseizure Medication in Patients with Lobar Intracerebral Hemorrhage.  Neurocrit Care  2025 Dec 18;. doi:10.1007/s12028-025-02423-w
  3. Dekker J, Oksuz BA, Zhang Y, Wang Y, Minsk MK, Kuang S, Yang L, Gibcus JH, Krietenstein N, Rando OJ  et al.  An integrated view of the structure and function of the human 4D nucleome.  Nature  2025 Dec 17;. doi:10.1038/s41586-025-09890-3
  4. Zhu F, Sinha A, Graça G, Neeland IJ, Pandey A, Tzoulaki I, Karaman I, Tracy RP, Lima JAC, Shah SJ  et al.  Serum Metabolites and Heart Failure Risk: MESA and RS.  J Am Heart Assoc  2025 Dec 16;14(24):e044211. doi:10.1161/JAHA.125.044211
  5. Frank SJ, Busse PM, Lee JJ, Rosenthal DI, Hernandez M, Swanson DM, Garden AS, Gunn GB, Patel SH, Snider JW  et al.  Proton versus photon radiotherapy for patients with oropharyngeal cancer in the USA: a multicentre, randomised, open-label, non-inferiority phase 3 trial.  Lancet  2025 Dec 11;. pii:S0140-6736(25)01962-2
  6. Verbitsky M, Khosla P, Bivona D, Khan A, Gupta Y, Park H, Shen TH, Ghotra A, Xu K, Ghavami IA  et al.  Urobiota analysis and genome-wide association study in pediatric recurrent urinary tract infections and vesicoureteral reflux.  JCI Insight  2025 Dec 09;. pii:e199689
  7. Li D, Liu S, Assis PR, Li M, Dong S, Whaling I, Jolanki O, Kagda M, Zhang W, Macias-Velasco JF  et al.  The IGVF catalog-from genetic variation to function.  Nucleic Acids Res  2025 Dec 08;. pii:gkaf1341
  8. Foà A, Vaduganathan M, Claggett BL, Desai AS, Jhund PS, Henderson AD, Chatur S, Amarante F, Hofmeister L, Horvat-Broecker A  et al.  Finerenone-Related Risk of Hypotension in Heart Failure With Mildly Reduced or Preserved Ejection Fraction.  JACC Heart Fail  2025 Dec 06;:102779. doi:10.1016/j.jchf.2025.102779
  9. Wong AF, Bilaver LA, Jiang J, Luo Y, Gupta RS, Rosenman M, Carroll MS  Assessing pediatric clinician adherence to the guidelines for prevention of peanut allergy: a natural language processing study.  BMC Med Inform Decis Mak  2025 Dec 06;. doi:10.1186/s12911-025-03287-y
  10. Mc Causland FR, Chatur S, Vaduganathan M, Claggett BL, Kulac IJ, Desai AS, Jhund PS, Henderson AD, Rohwedder K, Amarante F  et al.  Finerenone and Cardiovascular Outcomes According to Baseline Kidney Function in Patients With Heart Failure: The FINEARTS-HF Trial.  JACC Heart Fail  2025 Dec 05;:102778. doi:10.1016/j.jchf.2025.102778
  11. Guare LA, Das J, Caruth L, Rajagopalan A, Akerele AT, Brumpton BM, Chen TT, Kottyan L, Lin YF, Moreno E  et al.  Expanding the genetic landscape of endometriosis: Integrative -omics analyses implicate key genes and pathways in a multi-ancestry study of over one million women.  Res Sq  2025 Dec 04;. pii:rs.3.rs-8116602
  12. Stocks JK, Keszycki RM, Gutstein D, Parrish T, Castellani RJ, Geula C, Barbieri E, Weintraub S, Mesulam M, Gefen T  Biomarkers.  Alzheimers Dement  2025 Dec;21 Suppl 2:e100335. doi:10.1002/alz70856_100335
  13. Stocks JK, Keszycki RM, Gutstein D, Parrish T, Castellani RJ, Geula C, Barbieri E, Weintraub S, Mesulam M, Gefen T  Alzheimer's Imaging Consortium.  Alzheimers Dement  2025 Dec;21 Suppl 8(Suppl 8):e109842. pii:e109842
  14. Borlaug BA, Chirinos JA, Lewis GD, Redfield MM, Bertoni AG, Cadeiras M, Chiamvimonvat N, Desai AS, Givertz MM, Kass DA  et al.  Rationale and Design of the HeartShare/AMP-HF Deep Phenotyping Study to Improve Understanding of Heart Failure With Preserved Ejection Fraction.  JACC Heart Fail  2025 Dec;13(12):102714. doi:10.1016/j.jchf.2025.102714
  15. Abahuje E, Houskamp EJ, Silva Pinheiro do Nascimento J, Agha EM, Thompson WK, Michelson KN, Naidech A  Patient and clinician perspectives in the use of machine learning and artificial intelligence in the context of acute neurology.  JAMIA Open  2025 Dec;8(6):ooaf143. pii:ooaf143
  16. Ahmad FS, Wehbe RM, Wilcox JE  The SCAI Is Not the Limit: Refining Dynamic Shock Trajectories With Machine Learning-Based Phenotyping.  JACC Heart Fail  2025 Dec;13(12):102700. doi:10.1016/j.jchf.2025.102700
  17. Nateghi R, Zhou R, Saft M, Schnauss M, Neill C, Alam R, Handa N, Huang M, Li EV, Goldstein JA  et al.  Artificial Intelligence (AI)-Driven Screening of Equivocal Prostate Immunohistochemistry (IHC) Cases: Development and Validation of a Screening and Cancer Detection Framework.  Mod Pathol  2025 Dec;38(12):100904. doi:10.1016/j.modpat.2025.100904
  18. Crum Y, van Veldhuisen DJ, Shah SJ, Mylavarapu U, Hu M, Komtebedde J, Lobeek M, Hoendermis ES, Litwin SE, Solomon SD  et al.  Epicardial Adipose Tissue, Functional Status, and Invasive Hemodynamics in Heart Failure With Preserved Ejection Fraction.  JACC Adv  2025 Dec;4(12 Pt 2):102185. doi:10.1016/j.jacadv.2025.102185
  19. Gyberg DJ, Komtebedde J, Mylavarapu U, Litwin SE, Leon MB, Cutlip DE, Solomon SD, Starling RC, Cikes M, Borlaug BA  et al.  Refining Atrial Shunt Therapy for HFpEF: Lessons from Pivotal Randomized Trials and Emerging Directions.  J Card Fail  2025 Nov 29;. pii:S1071-9164(25)00436-1
  20. Pandey A, Moroney M, Verma S, Borlaug BA, Butler J, Davies MJ, Kitzman DW, Shah SJ, Petrie MC, Rönnbäck C  et al.  Effects of semaglutide in obesity-related heart failure with preserved ejection fraction across the age spectrum: Findings from the STEP-HFpEF programme.  Eur J Heart Fail  2025 Nov 25;. doi:10.1002/ejhf.70049
  21. Shimano KA, Grimes AB, Kaicker S, Shah SJ, Gunn E, Bhat RV, Kochhar M, Rothman JA, Rose MJ, Briones M  et al.  Eltrombopag for Newly Diagnosed Pediatric Immune Thrombocytopenia Requiring Treatment: The PINES Randomized Clinical Trial.  JAMA  2025 Nov 25;334(20):1816-1826. doi:10.1001/jama.2025.18168
  22. Samadian KD, Chua E, Peng B, Coleska A, Hassan A, Chong P, Locke B, Liebovitz DM, Rohlfsen C, He S  Entropy removal of clinical features.  Sci Rep  2025 Nov 23;. doi:10.1038/s41598-025-29069-0
  23. Ostrominski JW, Neuen BL, Claggett BL, Filippatos G, Desai AS, Jhund PS, Henderson A, Lam CSP, Senni M, Shah SJ  et al.  Timing of Cardiovascular and Kidney Benefits With Finerenone in Heart Failure and Chronic Kidney Disease With Type 2 Diabetes.  J Am Coll Cardiol  2025 Nov 18;. pii:S0735-1097(25)10071-5
  24. Ostrominski JW, Harrington J, Claggett BL, Filippatos G, Desai AS, Jhund PS, Henderson AD, Lam CSP, Senni M, Shah SJ  et al.  Anthropometric Measures, Cardiovascular Outcomes, and Treatment Effects of Finerenone in Cardiovascular-Kidney-Metabolic Disease: Pooled Participant-Level Analysis of 3 Global Trials.  J Am Coll Cardiol  2025 Nov 18;86(20):1781-1801. doi:10.1016/j.jacc.2025.08.039
  25. Alexander TJ, Gauen AM, Petito LC, Kohli-Lynch CN, Carton TW, Smith SM, Merritt G, Ahmad FS, Allen NB  Hypertension in Young Adults: Social Determinants of Prevalence, Awareness, Treatment, and Control.  Am J Hypertens  2025 Nov 13;. pii:hpaf203
  26. Ahmad FS, Khan SS, Levin MG  Implementation Intelligence With AI-Prospective Evaluations Needed.  JAMA Cardiol  2025 Nov 10;. doi:10.1001/jamacardio.2025.4668
  27. Fontana M, Garcia-Pavia P, Grogan M, Shah SJ, Engelmann MDM, Hovingh GK, Kristen AV, Lim-Watson M, Malling B, Kar S  et al.  Coramitug, a Humanized Monoclonal Antibody for the Treatment of Transthyretin Amyloid Cardiomyopathy: a Phase 2, Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial.  Circulation  2025 Nov 10;. doi:10.1161/CIRCULATIONAHA.125.077304
  28. Yu S, Fu Y, Wong JH, Wang J, Zhao H, Zhao J, Yue F  The 3D Genome Browser 2.0: an enhanced online platform for visualizing and analyzing 3D genome architecture.  Nucleic Acids Res  2025 Nov 09;. pii:gkaf1109
  29. Inciardi RM, Lu H, Claggett BL, Desai AS, Jhund PS, Henderson AD, Lam CSP, Merkely B, Miao MZ, Senni M  et al.  Finerenone in patients with severe heart failure: The FINEARTS-HF trial.  Eur J Heart Fail  2025 Nov 04;. doi:10.1002/ejhf.70083
  30. Wang H, Schwirtlich T, Houskamp E, Hutch M, Murphy J, Nascimento JSPD, Zini A, Brancaleoni L, Giacomozzi S, Luo Y  et al.  Automated Detection of the Black Hole Sign for Patients with Intracerebral Hemorrhage Using Self-Supervised Learning.  AJNR Am J Neuroradiol  2025 Nov 03;46(11):2300-2309. doi:10.3174/ajnr.A8826
  31. Biswas D, Thangaraj P, Pedroso AF, Ogunniyi MO, Maddox TM, Ahmad FS, Khera R  Artificial Intelligence for Cardiovascular Care in Action: From Learning to Implementation in Health Systems.  JACC Adv  2025 Nov;4(11 Pt 2):102307. pii:102307
  32. Mizuno A, Ahmad FS, Brahmbhatt DH  Behavioral Intelligence in Action: Implementation Science and Cardiovascular Learning Health Systems.  JACC Adv  2025 Nov;4(11 Pt 2):102351. pii:102351
  33. Amagai S, Chaudhari V, Chhikara K, Ingraham NE, Hochberg CH, Barker AK, Mao C, Ortiz AC, Weissman GE, Schmid BE  et al.  The Epidemiology of ICU Readmissions Across Ten Health Systems.  Crit Care Explor  2025 Nov 01;7(11):e1341. pii:e1341
  34. Chang AY, Kaufman JD, Shah SJ, Tan AX, Patel RB, Margolis HG, Psaty BM, Gardin JM, Al-Kindi S, Austin TR  et al.  Cross-Sectional Association of Ground-Level Ozone and Nitrogen Dioxide With Cardiac Mechanics Using Speckle-Tracking Echocardiography in the Cardiovascular Health Study.  Echocardiography  2025 Nov;42(11):e70330. doi:10.1111/echo.70330
  35. Mohr DC  Passive sensing in mental health: Challenges and opportunities.  J Psychopathol Clin Sci  2025 Nov;134(8):1034-1035. doi:10.1037/abn0001058
  36. Lakhtakia T, Smith SR, Meyerhoff J, Meng Y, Ungar LH, Mohr DC, Stamatis CA  Differential associations of passively sensed behaviors with in-vivo depression symptoms.  J Psychopathol Clin Sci  2025 Nov;134(8):860-871. doi:10.1037/abn0001059
  37. Borlaug BA, Kitzman DW, Patel S, Chinnakondepalli KM, Butler J, Davies MJ, Petrie MC, Shah SJ, Verma S, Núñez J  et al.  Semaglutide and Exercise Function in Obesity-Related HFpEF: Insights From the STEP-HFpEF Program.  JACC Heart Fail  2025 Nov;13(11):102660. doi:10.1016/j.jchf.2025.102660
  38. Ige MO, French DD, Chaudhury AS, Li Y, Andrews CA, Kanwar K, Zhou X, Marwah S, Evans CT, Kho AN  et al.  Quality of Care in Patients With Newly Diagnosed Glaucoma.  JAMA Ophthalmol  2025 Nov 01;143(11):893-902. doi:10.1001/jamaophthalmol.2025.2995
  39. Shetty NS, Gaonkar M, Pampana A, Patel N, Carson AP, Haring B, Psaty BM, Kooperberg C, Boerwinkle E, Rotter JI  et al.  Association of Pathogenic/Likely Pathogenic Inherited Cardiomyopathy Variants With Heart Failure: A TOPMed Multiancestry Analysis.  Mayo Clin Proc  2025 Nov;100(11):1948-1955. doi:10.1016/j.mayocp.2025.01.021
  40. Tibrewala A, Pham DT, Hu M, Petito LC, Rich JD, Gustafsson F, de By TMMH, Veen K, Lloyd-Jones DM, Shah SJ  Risk prediction model for waitlist mortality in patients with left ventricular assist devices.  JHLT Open  2025 Nov;10:100337. pii:100337
  41. Fass OZ, Kristinsdottir K, Kaklamanos E, Soni P, Hudson K, Etemadi M, Pandolfino JE, Carlson DA  Improved Performance of an Updated Artificial Intelligence Model for Interpretation of Functional Lumen Imaging Probe Panometry Studies.  Neurogastroenterol Motil  2025 Nov;37(11):e70120. doi:10.1111/nmo.70120
  42. Danziger GS, French DD, Li Y, Andrews CA, Marwah S, Rivera AS, Zhou X, Chaudhury AS, Mohamedali A, Aneja A  et al.  Rates and Associated Risk Factors for Cataract Surgery Complications in Academic Medical Centers.  J Cataract Refract Surg  2025 Oct 31;. doi:10.1097/j.jcrs.0000000000001822
  43. Maznyczka A, Nuis RJ, Shiri I, Ternacle J, Garot P, van den Dorpel MMP, Khokhar AA, De Lucia R, Orini M, Kutty S  et al.  Artificial Intelligence in Valvular Heart Disease: Innovations and Future Directions.  JACC Cardiovasc Interv  2025 Oct 27;18(20):2439-2457. doi:10.1016/j.jcin.2025.08.031
  44. Kruzan KP, Ammerman B, Lengel GJ, Griffith JW, Lucas K, Nguyen T, Rushton K, Washburn JJ, Mohr DC  Development and initial test of an online self-assessment of nonsuicidal self-injury severity.  J Affect Disord  2025 Oct 15;387:119506. doi:10.1016/j.jad.2025.119506
  45. Zelicha H, Weitzner ZN, Park S, Babb TG, Bernhardt V, Ahmad FS, Cella D, Chen Y, Livingston EH  Improvement in breathlessness following bariatric surgery as measured by a new heart failure-specific health-related quality of life instrument: a prospective longitudinal study.  Surg Obes Relat Dis  2025 Oct 10;. pii:S1550-7289(25)00955-4
  46. Li Z, LaPenna KB, Gehred ND, Yu X, Tang WHW, Doiron JE, Xia H, Chen J, Driver IH, Sachse FB  et al.  Dysregulated Protein s-Nitrosylation Promotes Nitrosative Stress and Disease Progression in Heart Failure With Preserved Ejection Fraction.  Circ Res  2025 Oct 10;137(9):1185-1206. doi:10.1161/CIRCRESAHA.124.326042
  47. Kaklamanos E, Kristinsdottir K, Wittbrodt M, Li M, Pitisuttithum P, Kou W, Keswani RN, Carlson D, Etemadi M, Pandolfino JE  From Pixels to Peristalsis: Comparing Achalasia Diagnosis With Artificial Intelligence With Expert Endoscopists.  Clin Gastroenterol Hepatol  2025 Oct 09;. pii:S1542-3565(25)00859-6
  48. Vaduganathan M, Claggett BL, Chatur S, Desai AS, Jhund PS, Vardeny O, Merkely B, Martinez F, Comin-Colet J, Kerr Saraiva JF  et al.  Lifetime benefits of comprehensive medical therapy in heart failure with mildly reduced or preserved ejection fraction.  Nat Med  2025 Oct 06;. doi:10.1038/s41591-025-04037-3
  49. Patel RB, Shah SJ  Easing the Strain: Atrial Function After Atrial Shunting.  Circ Heart Fail  2025 Oct;18(10):e013583. doi:10.1161/CIRCHEARTFAILURE.125.013583
  50. Pandey A, Kitzman DW, Chinnakondepalli KM, Patel S, Borlaug BA, Butler J, Davies MJ, Shah SJ, Verma S, Rönnbäck C  et al.  Frailty and Effects of Semaglutide in Obesity-Related HFpEF: Findings From the STEP-HFpEF Program.  JACC Heart Fail  2025 Oct;13(10):102610. doi:10.1016/j.jchf.2025.102610

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