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Northwestern University Feinberg School of Medicine
Institute for Artificial Intelligence in Medicine

Publications

Browse the list below to see the latest scientific publications stemming from our institute faculty’s work. To view publications of specific AI faculty, please visit Membership and select a profile link.

  1. Tibrewala A, Pham DT, Hu M, Petito LC, Rich JD, Gustafsson F, de By TMMH, Veen K, Lloyd-Jones DM, Shah SJ  Risk prediction model for waitlist mortality in patients with left ventricular assist devices.  JHLT Open  2025 Nov;10:100337. pii:100337
  2. Kruzan KP, Ammerman B, Lengel GJ, Griffith JW, Lucas K, Nguyen T, Rushton K, Washburn JJ, Mohr DC  Development and initial test of an online self-assessment of nonsuicidal self-injury severity.  J Affect Disord  2025 Oct 15;387:119506. doi:10.1016/j.jad.2025.119506
  3. Luo Y, Fraser L, Jezykowski J, Gupta NA, Miethke AG, Taylor SA, Alonso EM, Horslen S, Kohli R, Molleston JP  et al.  Interleukin 8-CXCR2-mediated neutrophil extracellular trap formation in biliary atresia associated with neutrophil extracellular trap-induced stellate cell activation.  Hepatology  2025 Sep 01;82(3):552-565. doi:10.1097/HEP.0000000000001195
  4. Shetty NS, Gaonkar M, Pampana A, Patel N, Carson AP, Haring B, Psaty BM, Kooperberg C, Boerwinkle E, Rotter JI  et al.  Association of Pathogenic/Likely Pathogenic Inherited Cardiomyopathy Variants With Heart Failure: A TOPMed Multiancestry Analysis.  Mayo Clin Proc  2025 Aug 22;. pii:S0025-6196(25)00095-3
  5. Tavakoli N, Rahsepar AA, Benefield BC, Shen D, López-Tapia S, Schiffers F, Goldberger JJ, Albert CM, Wu E, Katsaggelos AK  et al.  ScarNet: A Novel Foundation Model for Automated Myocardial Scar Quantification from Late Gadolinium-Enhancement Images.  J Cardiovasc Magn Reson  2025 Aug 20;:101945. doi:10.1016/j.jocmr.2025.101945
  6. Greene CA, Hampton G, Jaworski J, Shuey MM, Khan A, Luo Y, Jarvik GP, Namjou-Khales B, Edwards TL, Velez Edwards DR  et al.  Multi-ancestry meta-analysis of keloids uncovers novel susceptibility loci in diverse populations.  Nat Commun  2025 Aug 20;16(1):7770. pii:7770
  7. Chitsazan M, Parekh JK, Kosyakovsky LB, Nemeth SM, Lau ES, Januzzi JL, Wang TJ, Levy D, Ndumele CE, Selvin E  et al.  Natriuretic Peptide Cut Points for Heart Failure Classification in Individuals With and Without Obesity.  Circ Heart Fail  2025 Aug 20;:e013112. doi:10.1161/CIRCHEARTFAILURE.125.013112
  8. Hoffmann AD, Almubarak HF, Iyer R, Weinberg SE, Squires JR, Mao C, Wei J, Chaudhuri S, El-Shennawy L, Dashzeveg NK  et al.  Identification of immune signatures associated with both SARS-CoV-2 infection and lung transplantation.  Cell Rep Med  2025 Aug 19;6(8):102262. doi:10.1016/j.xcrm.2025.102262
  9. Xian S, Grabowska ME, Kullo IJ, Luo Y, Smoller JW, Walunas TL, Wei WQ, Jarvik GP, Mooney SD, Crosslin DR  Transformer patient embedding using electronic health records enables patient stratification and progression analysis.  NPJ Digit Med  2025 Aug 14;8(1):521. pii:521
  10. Cai FY, Mao C, Luo Y  Constrained Tensor Factorization for Cancer Phenotyping and Mortality Prediction.  Stud Health Technol Inform  2025 Aug 07;329:871-875. doi:10.3233/SHTI250964
  11. Khan SS, Harrington RA, Ahmad FS  Blood Pressure Measurement in Retail Stores and Population Health.  JAMA Cardiol  2025 Aug 06;. doi:10.1001/jamacardio.2025.2492
  12. Vaduganathan M, Claggett BL, Udell JA, Desai AS, Jhund PS, Henderson AD, Lay-Flurrie J, Amarante F, Glasauer A, Lam CSP  et al.  Blinded Withdrawal of Finerenone After Long-Term Treatment in the FINEARTS-HF Trial.  J Am Coll Cardiol  2025 Aug 05;86(5):396-399. doi:10.1016/j.jacc.2025.05.038
  13. Luo Z, Xia M, Shi W, Zhao C, Wang J, Xin D, Dong X, Xiong Y, Zhang F, Berry K  et al.  Retraction Note: Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis.  Nature  2025 Aug;644(8075):290. doi:10.1038/s41586-025-09015-w
  14. Ding Y, He B, Bogush D, Schramm J, Singh C, Dovat K, Randazzo J, Tukaramrao D, Hengst J, Annageldiyev C  et al.  Critical roles of IKAROS and HDAC1 in regulation of heterochromatin and tumor suppression in T-cell acute lymphoblastic leukemia.  Leukemia  2025 Aug;39(8):2010-2020. doi:10.1038/s41375-025-02651-1
  15. Klein L, Fudim M, Etemadi M, Gordon R, Tibrewala A, Hernandez-Montfort J, McCann P, Zier L, Shah K, Rollins A  et al.  Noninvasive Pulmonary Capillary Wedge Pressure Estimation in Heart Failure Patients With the Use of Wearable Sensing and AI.  JACC Heart Fail  2025 Aug;13(8):102513. doi:10.1016/j.jchf.2025.102513
  16. Butt JH, Jhund PS, Henderson AD, Claggett BL, Chiang CE, Linssen GCM, Saldarriaga CI, Saraiva JFK, Sato N, Schou M  et al.  Finerenone According to Frailty in Heart Failure: A Prespecified Analysis of the FINEARTS-HF Randomized Clinical Trial.  JAMA Cardiol  2025 Aug 01;10(8):829-840. doi:10.1001/jamacardio.2025.1775
  17. Ostrominski JW, Filippatos G, Claggett BL, Miao ZM, Desai AS, Jhund PS, D Henderson A, Scheerer MF, Rohwedder K, Amarante F  et al.  Efficacy and Safety of Finerenone in Heart Failure With Preserved Ejection Fraction: A FINE-HEART Analysis.  JACC Heart Fail  2025 Aug;13(8):102497. doi:10.1016/j.jchf.2025.03.041
  18. Ozyoruk KB, Harmon SA, Yilmaz EC, Gelikman DG, Bagci U, Simon BD, Merino MJ, Lis R, Gurram S, Wood BJ  et al.  Impact of AI-Generated ADC Maps on Computer-Aided Diagnosis of Prostate Cancer: A Feasibility Study.  Acad Radiol  2025 Aug;32(8):4621-4630. doi:10.1016/j.acra.2025.05.041
  19. Agha E, Sutter C, Ojewuyi I, Abramsohn EM, Andriano M, Bell C, Calix AL, Cherry JL, Downing K, Flower T  et al.  The Grief Navigation Trial: A multi-site pragmatic comparative effectiveness trial of two interventions to support parents after their child's unexpected or traumatic death.  Contemp Clin Trials  2025 Aug;155:107962. doi:10.1016/j.cct.2025.107962
  20. Masri A, Aras M, Grogan M, Jacoby D, Maurer MS, Shah SJ, Witteles R, Wong PW, Ji AX, DU J  et al.  Acoramidis for Transthyretin Amyloid Cardiomyopathy: Open-Label Extension Study Long-Term Follow-Up.  J Card Fail  2025 Aug;31(8):1354-1359. doi:10.1016/j.cardfail.2025.03.017
  21. Khan A, Gould PA, Luo Y, Prens EP, Wheless L, Hung AM, , Drivas TG, Ritchie MD, Saeidian AH  et al.  The polygenic architecture of hidradenitis suppurativa reveals signaling mechanisms that implicate epithelial remodeling.  medRxiv  2025 Jul 28;. pii:2025.07.25.25332168
  22. Chaudhary RS, Hussain SMD, Wang YS, Komtebedde J, Hasenfuß G, Borlaug BA, Kaye DM, Cleland JGF, Leon MB, Shah SJ  et al.  Expanded Definition of Worsening Heart Failure: Impact on Clinical Outcomes and Quality-of-Life Assessment.  JACC Heart Fail  2025 Jul 25;13(9):102571. doi:10.1016/j.jchf.2025.102571
  23. Yaku H, Sauer AJ, Patel S, O'Keefe EL, Borlaug BA, Kitzman DW, Windsor SL, Khumri T, Umpierrez G, Kosiborod MN  et al.  Orthostatic Pulse Pressure as a Potential Indicator of Preload Insufficiency in HFpEF: Insights From PRESERVED-HF.  JACC Heart Fail  2025 Jul 25;13(9):102566. doi:10.1016/j.jchf.2025.102566
  24. Huerta-Chagoya A, Kim J, Mandla R, Lu Y, Suzuki K, Petty LE, Ng HK, Choi J, Lee S, Rout M  et al.  Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries.  medRxiv  2025 Jul 23;. pii:2025.07.21.25331778
  25. Saleiro D, Wen JQ, Zannikou M, Lee B, Kosciuczuk EM, Nehlsen SD, Munshi A, Chen X, Oku CV, Hryhorysak B  et al.  Loss of Function Mouse Models Reveal a Novel Regulatory Function for ULK1 in Myeloproliferative Neoplasms.  Mol Cell Biol  2025 Jul 23;:1-24. doi:10.1080/10985549.2025.2529837
  26. Yaku H, Shah SJ  The Key Role of Diagnostic Imaging in Early HFpEF.  JACC Cardiovasc Imaging  2025 Jul 17;. pii:S1936-878X(25)00306-7
  27. Wang MC, Dolan B, Huang X, Freaney PM, Freed BH, Vega L, Markoski N, Wainright A, Kane B, Seegmiller LE  et al.  Feasibility of the Implementation of Tools for Heart Failure Risk Prediction: A Randomized Controlled Pilot Trial.  JACC Adv  2025 Jul 14;4(8):102004. pii:102004
  28. Prasad D, Khandeshi A, Sartin S, Jain R, Dahdaleh N, Lesniak M, Luo Y, Ahuja C  Will AI become our Co-PI?  NPJ Digit Med  2025 Jul 14;8(1):440. pii:440
  29. Fass OZ, Kristinsdottir K, Kaklamanos E, Soni P, Hudson K, Etemadi M, Pandolfino JE, Carlson DA  Improved Performance of an Updated Artificial Intelligence Model for Interpretation of Functional Lumen Imaging Probe Panometry Studies.  Neurogastroenterol Motil  2025 Jul 13;:e70120. doi:10.1111/nmo.70120
  30. Wang X, Li Y, Lin Z, Pla I, Gajjela R, Mattamana BB, Joshi M, Liu Y, Wang H, Zun AB  et al.  Microtopography-induced changes in cell nucleus morphology enhance bone regeneration by modulating the cellular secretome.  Nat Commun  2025 Jul 11;16(1):6444. pii:6444
  31. Rosenthal EA, Wei WQ, Luo Y, Namjou-Khales B, Schaid DJ, Esplin ED, Lape M, Kottyan L, Pacheco JA, Weng C  et al.  Phenome-wide association study identifies multiple traits associated with a polygenic risk score for colorectal cancer.  Hum Genomics  2025 Jul 09;19(1):77. pii:77
  32. Mithal LB, Becker ME, Ling-Hu T, Goo YA, Otero S, Kremer A, Pandey S, Lancki N, Li Y, Luo Y  et al.  Cord blood proteomics identifies biomarkers of early-onset neonatal sepsis.  JCI Insight  2025 Jul 08;10(13). pii:e193826
  33. Yaku H, Burkhoff D, Borlaug BA, Lala A, Butler J, Rich S, Shah SJ  Oral Levosimendan for the Treatment of Pulmonary Hypertension due to Heart Failure With Preserved Ejection Fraction: Rationale and Design of the LEVEL Trial.  J Card Fail  2025 Jul 07;. pii:S1071-9164(25)00293-3
  34. Hourmozdi J, Easton N, Benigeri S, Thomas JD, Narang A, Ouyang D, Duffy G, Upton R, Hawkes W, Akerman A  et al.  Evaluating the Performance and Potential Bias of Predictive Models for Detection of Transthyretin Cardiac Amyloidosis.  JACC Adv  2025 Jul 04;4(8):101901. pii:101901
  35. Yaku H, Eicher JC, Bergmann MW, Kister T, Pörner TC, Borlaug BA, Mohan RC, Price M, Komtebedde J, Shah SJ  Management of Flow Reversal in Patients With Atrial Shunts Implanted to Reduce Left Atrial Pressure.  JACC Case Rep  2025 Jul 02;30(17):103893. doi:10.1016/j.jaccas.2025.103893
  36. Naved BA, Ravishankar S, Colbert GE, Johnston A, Slott QM, Luo Y  LLM enabled classification of patient self-reported symptoms and needs in health systems across the USA.  NPJ Digit Med  2025 Jul 01;8(1):390. pii:390
  37. Pabon MA, Vardeny O, Vaduganathan M, Desai AS, Claggett BL, Kulac IJ, Jhund PS, Lam CSP, Senni M, Shah SJ  et al.  Finerenone in Heart Failure With Improved Ejection Fraction: The FINEARTS-HF Randomized Clinical Trial.  JAMA Cardiol  2025 Jul 01;10(7):740-745. doi:10.1001/jamacardio.2025.1101
  38. Barrett MA, Allen A, Vuong VT, Zhu D, Rainey AJ, McConnell WM, Kho AN, Salisbury A, French DD  Impact of an Artificial Intelligence and Machine Learning Enhanced Electronic Health Record System on Quality Measures in Nursing Homes: A Difference-in-Differences Analysis.  J Am Med Dir Assoc  2025 Jul;26(7):105680. doi:10.1016/j.jamda.2025.105680
  39. Butt JH, Jhund PS, Henderson AD, Claggett BL, Desai AS, Lam CSP, Brinker M, Schloemer P, Viswanathan P, Lage A  et al.  Finerenone, glycaemic status, and heart failure with mildly reduced or preserved ejection fraction: A prespecified analysis of the FINEARTS-HF trial.  Eur J Heart Fail  2025 Jul;27(7):1326-1341. doi:10.1002/ejhf.3649
  40. Dennis S, Tsukioki T, Kocherginsky M, Qi AK, DeHorn S, Gurley M, Wrubel E, Luo Y, Khan SA  Neoadjuvant Chemotherapy Response and Genetic Susceptibility in Recently Parous Women with Breast Cancer: A Retrospective Analysis.  Ann Surg Oncol  2025 Jul;32(7):4855-4864. doi:10.1245/s10434-025-17204-0
  41. Matsumoto S, Henderson AD, Jhund PS, Bauersachs J, Chioncel O, Claggett BL, Comin-Colet J, Desai AS, Filippatos G, Lam CSP  et al.  Finerenone and Atrial Fibrillation in Heart Failure: A Secondary Analysis of the FINEARTS-HF Randomized Clinical Trial.  JAMA Cardiol  2025 Jul 01;10(7):696-707. doi:10.1001/jamacardio.2025.0848
  42. Li M, Fass OZ, Carlson DA, Pitisuttithum P, Goudie E, Kristinsdottir K, Kaklamanos E, Etemadi M, Keswani RN, Ellison A  et al.  Endoscopic Prediction of Achalasia: Putting the CART Before the CARS.  Neurogastroenterol Motil  2025 Jul;37(7):e70024. pii:e70024
  43. Hosseini M, Holcombe AO, Kovacs M, Zwart H, Katz DS, Holmes K  Group authorship, an excellent opportunity laced with ethical, legal and technical challenges.  Account Res  2025 Jul;32(5):762-784. doi:10.1080/08989621.2024.2322557
  44. Herrold AA, Aaronson AL, Bhaumik D, Durazzo T, Livengood SL, Ramic A, Riordan P, Jordan N, Parrish T, Mallinson T  et al.  A Customized Neural Transcranial Magnetic Stimulation Target for Functional Disability Among Veterans With Co-Occurring Alcohol Use Disorder and Mild Traumatic Brain Injury: Protocol for a Pilot Randomized Controlled Trial.  JMIR Res Protoc  2025 Jun 23;14:e64909. pii:e64909
  45. Bisen JB, Sikora H, Aneja A, Shah SJ, Mirza RG  Retinal Imaging as a Window into Cardiovascular Health: Towards Harnessing Retinal Analytics for Precision Cardiovascular Medicine.  J Cardiovasc Dev Dis  2025 Jun 17;12(6). pii:230
  46. Li Y, Ding Y, Dennis S, Hutch MR, Zhou J, Zhou Y, Li Y, Pillai M, Ghotbaldini S, Garcia MA  et al.  SOAR elucidates biological insights and empowers drug discovery through spatial transcriptomics.  Sci Adv  2025 Jun 13;11(24):eadt7450. doi:10.1126/sciadv.adt7450
  47. Dennis SR, Tsukioki T, Cottone G, Zhou W, Ganz PA, Sehl ME, Luo Y, Khan SA, Clare S  DNA methylation patterns in breast cancer, paired benign tissue from ipsilateral and contralateral breast, and healthy controls.  Breast Cancer Res  2025 Jun 11;27(1):103. pii:103
  48. Doiron JE, Elbatreek MH, Xia H, Yu X, Gehred ND, Gromova T, Chen J, Driver IH, Muraoka N, Jensen M  et al.  Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF: Evidence for Synergistic Benefit With GLP-1/Glucagon Agonism.  JACC Basic Transl Sci  2025 Jun 04;:101297. doi:10.1016/j.jacbts.2025.04.011
  49. Huang J, Wittbrodt MT, Teague CN, Karl E, Galal G, Thompson M, Chapa A, Chiu ML, Herynk B, Linchangco R  et al.  Efficiency and Quality of Generative AI-Assisted Radiograph Reporting.  JAMA Netw Open  2025 Jun 02;8(6):e2513921. pii:e2513921
  50. Rambarat P, DeVore AD, Bhatt AS, Allen LA, McIlvennan CK, Cotter G, Mukhopadhyay A, Ahmad T, Ahmad FS, Psotka MA  Failure to Launch: Insights From Randomized Trials on Implementation Strategies for Guideline-Directed Therapies for Heart Failure.  JACC Heart Fail  2025 Jun;13(6):887-900. doi:10.1016/j.jchf.2025.02.023

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