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Northwestern University Feinberg School of Medicine
Institute for Artificial Intelligence in Medicine

Publications

Browse the list below to see the latest scientific publications stemming from our institute faculty’s work. To view publications of specific AI faculty, please visit Membership and select a profile link.

  1. Naved BA, Tran M, Slott QM, Francaviglia P, Amygdalidis M, Crandall P, Nadkarni G, Freeman R, Luo Y, Gavin N  "Check Symptoms & Get Care": Mount Sinai's AI Triage Solution.  NEJM Catal Innov Care Deliv  2026 Aug;7(8):CAT250394. doi:10.1056/CAT.25.0394
  2. Agha E, Miller C, Downing K, James K, McNicholas A, Newton S, Wershil SJ, Michelson KN  Feedback on a bereavement referral program after coroner referral following a child's unexpected death.  Death Stud  2026 Jul 30;:1-13. doi:10.1080/07481187.2026.2704574
  3. Cicek V, Hayiroglu MI, Sharma V, Rahsepar A, Markl M, Bagci U, Passman RS  AI-Driven Atrial Fibrillation Management: From Signal to Strategy.  Balkan Med J  2026 Jul 30;. doi:10.4274/balkanmedj.galenos.2026.2026-6-21
  4. Uegami W, Okoshi EN, Lami K, Nei Y, Ozasa M, Kataoka K, Kitamura Y, Kohashi Y, Cooper LAD, Sakanashi H  et al.  An Explainable Cryobiopsy AI Model, CRAI, to Predict Progression in Interstitial Pneumonia.  Mod Pathol  2026 Jul 29;:101047. doi:10.1016/j.modpat.2026.101047
  5. Hanafiah A, Geng Z, Liu T, Tai YT, Cai W, Wang Q, Christensen N, Liu Y, Yue F, Gao Z  cPRC1.2 and CTCF-mediated transition from poised to active chromatin loops at bivalent genes.  EMBO Rep  2026 Jul 23;. doi:10.1038/s44319-026-00885-3
  6. Rashidi AP, Perronne L, Krumpelman C, Hill V, Borhani AA, Subedi K, Kelahan L, Avery R, Savas H, Rusinak D  et al.  Physics-Informed Multiscale Decoding of Tissue Microstructure: The Gray Level Affinity Metrics (GLAM) Framework.  J Imaging Inform Med  2026 Jul 20;. doi:10.1007/s10278-026-02132-6
  7. Lund LH, Barandiarán Aizpurua A, Bollano E, Braun O, Brouwer JLP, Buikema JW, Cannata A, Gardner RS, Handoko ML, Lang CC  et al.  Safety, pharmacokinetics, and exploratory efficacy of the oral ghrelin receptor agonist AC01 in heart failure with reduced ejection fraction (GOAL-HF1): a randomised, double-blind, placebo-controlled, phase 1b/2a study.  Lancet  2026 Jul 18;408(10551):248-262. doi:10.1016/S0140-6736(26)00904-9
  8. Broden Arciprete EG, Michelson KN, Feder SL, Marr JW, Al-Roub N, Gouda SR, Jones AM, Schopen AB, Tapper AK, Pasek TA  et al.  Noticing and responding to end-of-life suffering in the PICU: A co-designed conceptual framework for nursing practice.  Intensive Crit Care Nurs  2026 Jul 16;96:104498. doi:10.1016/j.iccn.2026.104498
  9. He J, Bui Q, Fong MWM, Mohr DC, Metts CL, Wong AWK  Real-Time Associations Between Subjective Cognitive Concerns and Daily Activity Participation in Persons Aging With Stroke: Smartphone-Based Ecological Momentary Assessment Study.  JMIR Aging  2026 Jul 14;9:e80222. pii:e80222
  10. Hamed M, Naderian M, Bangash H, Hernandez V, Shaibi GQ, Arslan M, Saadatagah S, Sherafati A, Miller A, Kamzabek A  et al.  Implementing a Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease in a Diverse Cohort.  Genet Med  2026 Jul 11;:102662. doi:10.1016/j.gim.2026.102662
  11. Ostrominski JW, Claggett BL, Kulac IJ, Desai AS, Jhund PS, Henderson A, Lam CSP, Senni M, Shah SJ, Voors AA  et al.  Finerenone and Blood Pressure in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: The FINEARTS-HF Randomized Clinical Trial.  JAMA Cardiol  2026 Jul 08;. pii:e262104
  12. Chow PI, You W, Shaffer KM, Cohn WF, Showalter SL, Orange C, Ritterband LM, Mohr DC  Digital Mental Health Treatment and Symptoms of Depression and Anxiety in Breast Cancer Survivors: A Randomized Clinical Trial.  JAMA Netw Open  2026 Jul 01;9(7):e2623871. pii:e2623871
  13. He Y, Zhao Y, Zhang R, Yang H, Zhang Z, Ren P, Luo C, Zhang P, Zhang Z, Hou S  et al.  Integrating cytological images and spatial transcriptomics for cell segmentation with DISSECT.  Nat Comput Sci  2026 Jul;6(7):718-731. doi:10.1038/s43588-026-01020-x
  14. Willis A, Lee C, Krogue J, Wickramanayake A, Young-Lin N, Caron S, Cheruiyot P, Watters A, Martín A, Tiyasirichokchai T  et al.  Generalization of AI-Based Gestational Age Assessment Using Blind Sweep Ultrasonography.  JAMA Netw Open  2026 Jul 01;9(7):e2622484. pii:e2622484
  15. Chakrabarty RP, Van Vranken JG, Aoi Y, Poor TA, McElroy GS, Vasan K, Soliman SHA, Iwanaszko M, Grant RA, Howard BC  et al.  Mitochondrial L-2-hydroxyglutarate is a physiological signalling metabolite.  Nature  2026 Jul;655(8124):1037-1047. doi:10.1038/s41586-026-10564-x
  16. Schnauss M, Handa N, Nateghi R, Alam R, Jang JW, Huang MM, Abrams A, Neill C, Kumar SKSR, Hubbard N  et al.  Clinical and Reader Associated Correlates of Clinically Significant Magnetic Resonance Imaging-Invisible Prostate Cancer Based on Negative Scans.  J Urol  2026 Jul;216(1):25-33. doi:10.1097/JU.0000000000005028
  17. Peng L, Perronne L, Gennaro N, Rashidi AP, Kobus Z, Seo M, Borhani AA, Kelahan L, Subedi K, Savas H  et al.  Performance of deep learning-based segmentation of soft tissue sarcoma by MRI sequence, tumor type and location.  Skeletal Radiol  2026 Jul;55(7):1539-1548. doi:10.1007/s00256-026-05178-3
  18. Hosseini M, Eisenman D, Riddle J, Pyle S, Peters A, Cobb N, Holmes K  Guidelines needed for the use of AI in the preparation or review of IRB, IBC, and IACUC applications.  Account Res  2026 Jul;33(5):2612564. doi:10.1080/08989621.2025.2612564
  19. Gyberg DJ, Komtebedde J, Mylavarapu U, Litwin SE, Leon MB, Cutlip DE, Solomon SD, Starling RC, Cikes M, Borlaug BA  et al.  Refining Atrial Shunt Therapy for Heart Failure With Preserved Ejection Fraction: Lessons From Pivotal Randomized Trials and Emerging Directions.  J Card Fail  2026 Jul;32(7):1246-1256. doi:10.1016/j.cardfail.2025.08.020
  20. Ayad M, Cooper LAD, Brat DJ  Inferring DNA Methylation Class from Digitized Pathology Images and AI: A Worthy and Timely Application with Room for Improved Clinical Performance.  Neuro Oncol  2026 Jun 30;. pii:noag149
  21. Sharma A, Nateghi R, Ayad M, Cooper LAD, Goldstein JA  Machine learning identification of maternal inflammatory response and systemic inflammatory response from placental membrane whole slide images.  Placenta  2026 Jun 24;181:204-210. doi:10.1016/j.placenta.2026.05.028
  22. Lu H, Schneider SR, Pabón MA, Claggett BL, Miao MZ, Desai AS, Jhund PS, Henderson A, Lam CSP, Senni M  et al.  Sleep Apnea in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: The FINEARTS-HF Trial.  JACC Heart Fail  2026 Jun 23;:103187. doi:10.1016/j.jchf.2026.103187
  23. Xian S, Smoller JW, Luo Y, Walunas TL, Liu C, Khan A, Weng C, Kullo IJ, Wei WQ, Jarvik GP  et al.  Unsupervised characterization of 100,272 EHR patients identifies high-risk groups and comorbidities linked to premature aging.  NPJ Digit Med  2026 Jun 23;. doi:10.1038/s41746-026-02913-x
  24. Bodelon C, Amgad M, Hodge JM, Elsebaie MAT, Landry M, Peng C, Tamimi RM, Kraft P, McCullough LE, Sherman ME  et al.  Effects of breast cancer risk factors on the tumor microenvironment: a morphological deep-learning analysis of three prospective cohorts.  NPJ Breast Cancer  2026 Jun 22;. doi:10.1038/s41523-026-00994-1
  25. Sethi I, Khan S, Lyons PG, Gao CA, Luo Y, Miltz D, Tovar S, Lohuis CT, Polly DM, Dave SB  et al.  Large Language Models Provide Accurate but Potentially Unsafe Answers to Multimodal Critical Care Medicine Board Review Questions.  Crit Care Med  2026 Jun 18;. doi:10.1097/CCM.0000000000007228
  26. Oh D, Choi HS, Mohr DC, Na H  Effects of a mobile-based self-management program on mental health in young adults: a randomized controlled trial.  Front Public Health  2026;14:1830292. pii:1830292
  27. Cheema BS, Boztepe B, Awofolaju MO, Hubbard MS, Marcus WB, Palella FJ, Abdel-Mohsen M, Liebovitz DM, Gill MK, Cotton RJ  et al.  Functional, molecular, and digital measurements of biological age.  J Clin Invest  2026 Jun 15;136(12). pii:e205777
  28. Xian S, Grabowska ME, Kullo IJ, Luo Y, Smoller JW, Walunas TL, Wei WQ, Jarvik G, Mooney S, Crosslin D  Author Correction: Transformer patient embedding using electronic health records enables patient stratification and progression analysis.  NPJ Digit Med  2026 Jun 11;9(1). pii:445
  29. Doi S, Kazui S, Akashi N, Patel RB, Komtebedde J, Mylavarapu U, Swarup V, Winkler S, Backhaus SJ, Litwin SE  et al.  Heart Failure Duration, Cardiac Remodeling, Dysfunction, and Hemodynamic Severity in HFpEF and HFmrEF: Insights From REDUCE LAP-HF II.  JACC Heart Fail  2026 Jun 05;:103167. doi:10.1016/j.jchf.2026.103167
  30. Bertoni AG, Bancks MP, Crago L, Chen H, Barr RG, Smith BM, Shah SJ  The Association of Race and Ethnicity with Six-Minute Walk Distance: The Multi-Ethnic Study of Atherosclerosis.  Ethn Dis  2026 Jan;36(1):22-29. doi:10.18865/EthnDis-2024-36
  31. Lewis ACF, Clayton EW, Bangash H, Bland HT, Bonini KE, Cimino JJ, Connolly JJ, Freimuth RR, Fullerton SM, Hakonarson H  et al.  Navigating data sharing in research.  Am J Hum Genet  2026 Jun 04;113(6):1159-1167. doi:10.1016/j.ajhg.2026.04.004
  32. Foà A, Pabon MA, Filippatos G, Claggett BL, Miao ZM, Jhund PS, Henderson A, Brinker M, Lage A, Hofmeister L  et al.  Effects of Finerenone on Sudden Death Across the Cardio-Kidney-Metabolic Landscape: A FINE-HEART Analysis.  J Am Coll Cardiol  2026 Jun 03;. pii:S0735-1097(26)06417-X
  33. Parkinson G, Patel R, Bergstrom C, Vadasz B, Amgad M, Cooper LAD, Sparano J, Lu J  Artificial Intelligence in Oncology: Clinical Applications, Challenges, and Opportunities.  Am Soc Clin Oncol Educ Book  2026 Jun;46(3):e520716. doi:10.1200/EDBK-26-520716
  34. Masri A, Cappelli F, Davis MK, Fontana M, Garcia-Pavia P, Gillmore JD, Hanna M, Obici L, Solomon SD, Sperry BW  et al.  Rationale and Design of CARDIO-TTRansform, a Phase 3 Trial of Eplontersen in Transthyretin Amyloid Cardiomyopathy.  Circ Heart Fail  2026 Jun;19(6):e014205. doi:10.1161/CIRCHEARTFAILURE.126.014205
  35. Shah SJ  Precision Medicine Is Not Optional, It's Oxygen: Reconciling Heart Failure With Preserved Ejection Fraction Trial Results Through the Lens of Phenotypic Diversity.  Struct Heart  2026 Jun;10(6):100778. pii:100778
  36. Lu H, Kosztin A, Claggett BL, Foà A, Pabón MA, Desai AS, Jhund PS, Henderson AD, Merkely B, Lam CSP  et al.  Biomarker, Functional Status, and Quality-of-Life Trajectories Before Modes of Death in Heart Failure: Post Hoc Analysis of the FINEARTS-HF Randomized Clinical Trial.  JAMA Cardiol  2026 Jun 01;11(6):574-582. doi:10.1001/jamacardio.2026.0682
  37. Banker M, do Nascimento JSP, Shownkeen H, Chang TR, Goldenberg F, Faine B, Cella D, Schuele SU, Luo Y, Tipton E  et al.  Prophylactic Antiseizure Medication in Patients with Lobar Intracerebral Hemorrhage.  Neurocrit Care  2026 Jun;44(3):850-856. doi:10.1007/s12028-025-02423-w
  38. Kaklamanos E, Kristinsdottir K, Wittbrodt M, Li M, Pitisuttithum P, Kou W, Keswani RN, Carlson D, Etemadi M, Pandolfino JE  From Pixels to Peristalsis: Comparing Achalasia Diagnosis With Artificial Intelligence With Expert Endoscopists.  Clin Gastroenterol Hepatol  2026 Jun;24(6):1542-1549. doi:10.1016/j.cgh.2025.09.034
  39. Yaku H, Burkhoff D, Borlaug BA, Lala A, Butler J, Rich S, Shah SJ  Oral Levosimendan for the Treatment of Pulmonary Hypertension due to Heart Failure With Preserved Ejection Fraction: Rationale and Design of the LEVEL Trial.  J Card Fail  2026 Jun;32(6):1059-1071. doi:10.1016/j.cardfail.2025.06.009
  40. Akerele AT, Hampton G, Kim J, Jaworski J, Lewis TJ, Khan A, Rasmussen-Torvik LJ, Luo Y, Jasper EA, Hellwege JN  et al.  Genetically-predicted placental gene expression links to uterine fibroids and endometriosis.  Placenta  2026 May 22;179:14-22. doi:10.1016/j.placenta.2026.03.023
  41. Perronne L, Gennaro N, Kobus Z, Seo M, Borhani AA, Kelahan L, Savas H, Avery R, Subedi K, Krumpelman C  et al.  A Predictive MRI Radiomics Model for Histologic Differentiation in Soft Tissue Sarcomas.  Cancers (Basel)  2026 May 21;18(10). pii:1667
  42. Singla A, Park S, Pedamallu H, Chen K, Robelly B, Rebello C, Lantz C, Zhao L, LaCombe R, Sinha R  et al.  Diagnostic Performance and Resource Utilization of Combining Blood Gene Expression, Cell-Free DNA, and Urine Chemokines for Monitoring Kidney Rejection.  Clin J Am Soc Nephrol  2026 May 21;. doi:10.2215/CJN.0000001075
  43. Henderson AD, Docherty KF, Talebi A, Kondo T, Petrie MC, Claggett BL, Desai AS, Vaduganathan M, Atherton JJ, Bauersachs J  et al.  A Bayesian analysis of finerenone in heart failure with mildly reduced and preserved ejection fraction: a pre-specified analysis of FINEARTS-HF.  Eur Heart J Cardiovasc Pharmacother  2026 May 19;12(3):176-185. doi:10.1093/ehjcvp/pvag010
  44. Makuvire TT, Lam CSP, Pabon MA, Claggett BL, Kulac IJ, Desai AS, Jhund PS, Henderson AD, Amarante F, Chen M  et al.  Geographic Variation in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: Insights From the FINEARTS-HF Trial.  JACC Heart Fail  2026 May 15;:103105. doi:10.1016/j.jchf.2026.103105
  45. Helseth R, Claggett BL, Bhatt A, Vardeny O, Lu H, Desai AS, Jhund PS, Henderson A, Lam CSP, Senni M  et al.  Viral respiratory tract infections in heart failure: the FINEARTS-HF trial.  Eur Heart J  2026 May 11;. pii:ehag384
  46. Hamatani Y, Claggett BL, Kulac IJ, Desai AS, Jhund PS, Henderson AD, Lam CSP, Senni M, Shah SJ, Voors AA  et al.  Finerenone, polypharmacy, and clinical outcomes in heart failure: pre-specified analysis from the FINEARTS-HF trial.  Eur J Heart Fail  2026 May 11;28(2):194-203. doi:10.1093/ejhf/xuag030
  47. Khan SS, Lloyd-Jones D, Pagidipati NJ, Shah SJ, Pawlowski C, Hogan L, Williams J, Leopold J  HFpEF Explained - Living with HFpEF.  N Engl J Med  2026 May 07;394(18):e35. doi:10.1056/NEJMp2516849
  48. Hafer N, Cielo K, Duguid P, Dunn M, Gholami M, Holmes K, Hunt J, Kane C, Moussatche P, Navarro C  et al.  Crowdsourced educational resource to distinguish Translational Science (TS) from Translational Research (TR).  J Clin Transl Sci  2026;10(1):e87. pii:e87
  49. Fejzo M, Wang X, Tan Q, Zöllner J, Pujol-Gualdo N, Laisk T, , Finer S, van Heel DA,   et al.  Publisher Correction: Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting.  Nat Genet  2026 May;58(5):1186. doi:10.1038/s41588-026-02608-9
  50. Marrero N, Jha K, Grant JK, Razavi AC, Budoff MJ, Shah SJ, Rotter JI, Blumenthal RS, Post WS, Gulati M  et al.  Sex-Specific Prognostic Value of Aortic Valve Calcium and the Risk for Aortic Stenosis: Multi-Ethnic Study of Atherosclerosis (MESA).  Circ Cardiovasc Imaging  2026 May;19(5):e018849. doi:10.1161/CIRCIMAGING.125.018849

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