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Northwestern University Feinberg School of Medicine
Institute for Artificial Intelligence in Medicine

Publications

Browse the list below to see the latest scientific publications stemming from our institute faculty’s work. To view publications of specific AI faculty, please visit Membership and select a profile link.

  1. Tibrewala A, Pham DT, Hu M, Petito LC, Rich JD, Gustafsson F, de By TMMH, Veen K, Lloyd-Jones DM, Shah SJ  Risk prediction model for waitlist mortality in patients with left ventricular assist devices.  JHLT Open  2025 Nov;10:100337. pii:100337
  2. Kruzan KP, Ammerman B, Lengel GJ, Griffith JW, Lucas K, Nguyen T, Rushton K, Washburn JJ, Mohr DC  Development and initial test of an online self-assessment of nonsuicidal self-injury severity.  J Affect Disord  2025 Oct 15;387:119506. doi:10.1016/j.jad.2025.119506
  3. Li Z, LaPenna KB, Gehred ND, Yu X, Tang WHW, Doiron JE, Xia H, Chen J, Driver IH, Sachse FB  et al.  Dysregulated Protein s-Nitrosylation Promotes Nitrosative Stress and Disease Progression in Heart Failure With Preserved Ejection Fraction.  Circ Res  2025 Oct 10;137(9):1185-1206. doi:10.1161/CIRCRESAHA.124.326042
  4. Ahmad FS, Wehbe RM, Wilcox JE  The SCAI Is Not the Limit: Refining Dynamic Shock Trajectories With Machine Learning-Based Phenotyping.  JACC Heart Fail  2025 Oct 08;:102700. doi:10.1016/j.jchf.2025.102700
  5. Kaklamanos E, Kristinsdottir K, Wittbrodt M, Li M, Pitisuttithum P, Kou W, Keswani RN, Carlson D, Etemadi M, Pandolfino JE  From Pixels to Peristalsis: Comparing Achalasia Diagnosis with Artificial Intelligence to Expert Endoscopists.  Clin Gastroenterol Hepatol  2025 Oct 07;. pii:S1542-3565(25)00859-6
  6. Vaduganathan M, Claggett BL, Chatur S, Desai AS, Jhund PS, Vardeny O, Merkely B, Martinez F, Comin-Colet J, Kerr Saraiva JF  et al.  Lifetime Benefits of Comprehensive Medical Therapy in Heart Failure with Mildly Reduced or Preserved Ejection Fraction.  Nat Med  2025 Oct 06;. doi:10.1038/s41591-025-04037-3
  7. Borlaug BA, Kitzman DW, Patel S, Chinnakondepalli KM, Butler J, Davies MJ, Petrie MC, Shah SJ, Verma S, Núñez J  et al.  Semaglutide and Exercise Function in Obesity-Related HFpEF: Insights From the STEP-HFpEF Program.  JACC Heart Fail  2025 Oct 03;13(11):102660. doi:10.1016/j.jchf.2025.102660
  8. Nateghi R, Zhou R, Saft M, Schnauss M, Neill C, Alam R, Handa N, Huang M, Li EV, Goldstein JA  et al.  AI-driven screening of equivocal prostate IHC cases: development and validation of a screening and cancer detection framework.  Mod Pathol  2025 Oct 01;:100904. doi:10.1016/j.modpat.2025.100904
  9. Pandey A, Kitzman DW, Chinnakondepalli KM, Patel S, Borlaug BA, Butler J, Davies MJ, Shah SJ, Verma S, Rönnbäck C  et al.  Frailty and Effects of Semaglutide in Obesity-Related HFpEF: Findings From the STEP-HFpEF Program.  JACC Heart Fail  2025 Oct;13(10):102610. doi:10.1016/j.jchf.2025.102610
  10. Butt JH, de Boer RA, Docherty KF, Kondo T, Hernandez AF, Inzucchi SE, Kosiborod MN, Køber L, Lam CSP, Martinez FA  et al.  Dapagliflozin, Heart Failure, and Duration of Diabetes: A Patient-Level Pooled Meta-Analysis of DAPA-HF and DELIVER.  JACC Heart Fail  2025 Oct;13(10):102630. doi:10.1016/j.jchf.2025.102630
  11. Lu H, Claggett BL, Vaduganathan M, Desai AS, Jhund PS, Voors AA, Senni M, Zannad F, Pitt B, Shah SJ  et al.  Temporal Changes in Biomarkers, Functional Status, and Quality of Life Prior to Adverse Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction.  JACC Heart Fail  2025 Oct;13(10):102590. doi:10.1016/j.jchf.2025.102590
  12. Khan SS, Harrington RA, Ahmad FS  Blood Pressure Measurement in Retail Stores and Population Health.  JAMA Cardiol  2025 Oct 01;10(10):1049. doi:10.1001/jamacardio.2025.2492
  13. Yaku H, Shah SJ  The Key Role of Diagnostic Imaging in Early HFpEF.  JACC Cardiovasc Imaging  2025 Oct;18(10):1145-1160. doi:10.1016/j.jcmg.2025.05.016
  14. Choi J, Gordon A, Eresen A, Zhang Z, Borhani A, Bagci U, Lewandowski R, Kim DH  Current applications of radiomics in the assessment of tumor microenvironment of hepatocellular carcinoma.  Abdom Radiol (NY)  2025 Oct;50(10):4661-4675. doi:10.1007/s00261-025-04916-w
  15. Lei Y, Li Z, Bui Q, DePaul O, Nicol GE, Mohr DC, Fong MWM, Metts CL, Lee SI, Tomazin SE  et al.  Satisfaction, user experiences, and initial efficacy of a technology-supported self-management intervention (iSMART) to improve post-stroke functioning: a remoted randomized controlled trial.  Top Stroke Rehabil  2025 Oct;32(7):677-691. doi:10.1080/10749357.2025.2450950
  16. Zhang B, Wu Q, Jhaveri R, Zhou T, Becich MJ, Bisyuk Y, Blanceró F, Chrischilles EA, Chuang CH, Cowell LG  et al.  Long COVID associated with SARS-CoV-2 reinfection among children and adolescents in the omicron era (RECOVER-EHR): a retrospective cohort study.  Lancet Infect Dis  2025 Sep 30;. pii:S1473-3099(25)00476-1
  17. Naved BA, Han S, Koss KM, Kando MJ, Wang JJ, Chang J, Weiss C, Passman MG, Wertheim JA, Luo Y  et al.  Revealing gait as a murine biomarker of injury, disease, and age with multivariate statistics and machine learning.  Sci Rep  2025 Sep 29;15(1):33457. pii:33457
  18. Patel RB, Shah SJ  Easing the Strain: Atrial Function After Atrial Shunting.  Circ Heart Fail  2025 Sep 26;:e013583. doi:10.1161/CIRCHEARTFAILURE.125.013583
  19. Oshinubi K, Chen Y, Doerry E, Gel ES, Hepp C, Lant T, Mehrotra S, Sabo S, Mihaljevic J  A Systematic Review of Spatial Epidemiological Modeling Approaches Applied During the COVID-19 Pandemic.  medRxiv  2025 Sep 25;. pii:2025.09.24.25336493
  20. Donnelly JM, Neff RA, Sedlack AJH, Juska VB, Ayala-Cardona LF, Bass J, McNally EM, Shah SJ, Alshurafa N, Kimchi EY  et al.  From reactive to proactive: Continuous protein monitoring for preventive health care.  Science  2025 Sep 25;389(6767):eady6497. doi:10.1126/science.ady6497
  21. Wang Z, Cao L, Jin Q, Chan J, Wan N, Afzali B, Cho HJ, Choi CI, Emamverdi M, Gill MK  et al.  A foundation model for human-AI collaboration in medical literature mining.  Nat Commun  2025 Sep 24;16(1):8361. pii:8361
  22. Marrero N, Jha K, Grant J, Razavi AC, Budoff MJ, Shah SJ, Rotter JI, Blumenthal RS, Post WS, Shaw LJ  et al.  Impact of Age on Aortic Valve Calcium Progression and Risk for Aortic Stenosis: Multi-Ethnic Study of Atherosclerosis.  Eur Heart J Cardiovasc Imaging  2025 Sep 23;. pii:jeaf279
  23. Pour-Rashidi A, Zandpazandi S, Perronne L, Hill VB, Krumpelman C, Subedi K, Kelahan L, Borhani AA, Savas H, Avery R  et al.  Intracranial Metastases from Uterine Leiomyosarcoma: A Systematic Review and Case Illustration.  J Clin Med  2025 Sep 20;14(18). pii:6631
  24. Ige MO, French DD, Chaudhury AS, Li Y, Andrews CA, Kanwar K, Zhou X, Marwah S, Evans CT, Kho AN  et al.  Quality of Care in Patients With Newly Diagnosed Glaucoma.  JAMA Ophthalmol  2025 Sep 18;. pii:e252995
  25. Bene-Alhasan Y, Bartz TM, Djoussé L, Ix J, Siscovick D, Gottdiener JS, Tracy RP, Hirsch CH, Newman AB, Shah SJ  et al.  Advanced Glycation End-Product Carboxymethyl-Lysine and Incident Heart Failure and Atrial Fibrillation in Older Adults.  J Am Heart Assoc  2025 Sep 16;14(18):e040640. doi:10.1161/JAHA.124.040640
  26. Ostrominski JW, Filippatos G, Claggett BL, Miao ZM, Desai AS, Jhund PS, Henderson A, Rohwedder K, Brinker MD, Scalise A  et al.  Effect of Finerenone on Morbidity and Mortality in CKD.  J Am Soc Nephrol  2025 Sep 12;. doi:10.1681/ASN.0000000823
  27. Huang X, Hughes Z, Fonarow GC, Ahmad FS, Shah NS, Chuzi S, Kershaw KN, Greenland P, Khan SS, Petito LC  Racial and Ethnic Differences in Patient Age at First Hospitalization for Heart Failure.  J Am Coll Cardiol  2025 Sep 09;86(10):711-720. doi:10.1016/j.jacc.2025.06.046
  28. Jain SS, Mortazavi BJ, Chan You S, Yao X, Lam CSP, Elias P, Poterucha TJ, Avram R, Tison GH, Pirruccello J  et al.  Moving Beyond the Model: Our Perspective on Meaningful AI Research in Cardiovascular Care.  J Am Coll Cardiol  2025 Sep 09;86(10):691-695. doi:10.1016/j.jacc.2025.07.040
  29. Ostrominski JW, Claggett BL, Desai AS, Jhund PS, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F, Pitt B  et al.  Finerenone according to insulin resistance in heart failure: Insights from the FINEARTS-HF trial.  Eur J Heart Fail  2025 Sep 08;. doi:10.1002/ejhf.70034
  30. McArthur E, Rinker DC, Cheng Y, Wang Q, Wang J, Gilbertson EN, Fudenberg G, Pittman M, Keough K, Yue F  et al.  Reconstructing the 3D genome organization of Neanderthals reveals that chromatin folding shaped phenotypic and sequence divergence.  bioRxiv  2025 Sep 02;. pii:2022.02.07.479462
  31. Singla A, Chen K, Robelly B, Rebello C, Lantz C, Zhao L, Sinha R, Park S, Kleiboeker S, Friedewald JJ  et al.  Using Torque Teno Virus as a Serial Monitoring Tool for the Net State of Immunosuppression of Kidney Transplant Recipients.  Clin Transplant  2025 Sep;39(9):e70321. doi:10.1111/ctr.70321
  32. Hensley CP, Kho AN, Kritselis A, Song J, Lee J, Chang AH  Preoperative Factors Associated With Falls Following Total Hip Arthroplasty in Older Adults.  ACR Open Rheumatol  2025 Sep;7(9):e70091. pii:e70091
  33. Zhang P, Mao C, Sun A, Yang Y, Hou Y, Fu Z, Babak T, Leverenz JB, Pieper AA, Luo Y  et al.  Real-world observations of GLP-1 receptor agonists and SGLT-2 inhibitors as potential treatments for Alzheimer's disease.  Alzheimers Dement  2025 Sep;21(9):e70639. pii:e70639
  34. Chaudhary RS, Hussain SMD, Wang YS, Komtebedde J, Hasenfuß G, Borlaug BA, Kaye DM, Cleland JGF, Leon MB, Shah SJ  et al.  Expanded Definition of Worsening Heart Failure: Impact on Clinical Outcomes and Quality-of-Life Assessment.  JACC Heart Fail  2025 Sep;13(9):102571. doi:10.1016/j.jchf.2025.102571
  35. Yaku H, Sauer AJ, Patel S, O'Keefe EL, Borlaug BA, Kitzman DW, Windsor SL, Khumri T, Umpierrez G, Kosiborod MN  et al.  Orthostatic Pulse Pressure as a Potential Indicator of Preload Insufficiency in HFpEF: Insights From PRESERVED-HF.  JACC Heart Fail  2025 Sep;13(9):102566. doi:10.1016/j.jchf.2025.102566
  36. Luo Y, Fraser L, Jezykowski J, Gupta NA, Miethke AG, Taylor SA, Alonso EM, Horslen S, Kohli R, Molleston JP  et al.  Interleukin 8-CXCR2-mediated neutrophil extracellular trap formation in biliary atresia associated with neutrophil extracellular trap-induced stellate cell activation.  Hepatology  2025 Sep 01;82(3):552-565. doi:10.1097/HEP.0000000000001195
  37. Crum Y, van Veldhuisen DJ, Shah SJ, Mylavarapu U, Hu M, Komtebedde J, Lobeek M, Hoendermis ES, Litwin SE, Solomon SD  et al.  Epicardial adipose tissue, functional status and invasive hemodynamics in heart failure with preserved ejection fraction.  JACC Adv  2025 Aug 26;:102185. doi:10.1016/j.jacadv.2025.102185
  38. Shetty NS, Gaonkar M, Pampana A, Patel N, Carson AP, Haring B, Psaty BM, Kooperberg C, Boerwinkle E, Rotter JI  et al.  Association of Pathogenic/Likely Pathogenic Inherited Cardiomyopathy Variants With Heart Failure: A TOPMed Multiancestry Analysis.  Mayo Clin Proc  2025 Aug 22;. pii:S0025-6196(25)00095-3
  39. Ostrominski JW, Harrington J, Claggett BL, Filippatos G, Desai AS, Jhund PS, Henderson AD, Lam CSP, Senni M, Shah SJ  et al.  Anthropometric Measures, Cardiovascular Outcomes, and Treatment Effects of Finerenone in Cardiovascular-Kidney-Metabolic Disease: Pooled Participant-Level Analysis of Three Global Trials.  J Am Coll Cardiol  2025 Aug 20;. pii:S0735-1097(25)07505-9
  40. Tavakoli N, Rahsepar AA, Benefield BC, Shen D, López-Tapia S, Schiffers F, Goldberger JJ, Albert CM, Wu E, Katsaggelos AK  et al.  ScarNet: A Novel Foundation Model for Automated Myocardial Scar Quantification from Late Gadolinium-Enhancement Images.  J Cardiovasc Magn Reson  2025 Aug 20;:101945. doi:10.1016/j.jocmr.2025.101945
  41. Greene CA, Hampton G, Jaworski J, Shuey MM, Khan A, Luo Y, Jarvik GP, Namjou-Khales B, Edwards TL, Velez Edwards DR  et al.  Multi-ancestry meta-analysis of keloids uncovers novel susceptibility loci in diverse populations.  Nat Commun  2025 Aug 20;16(1):7770. pii:7770
  42. Chitsazan M, Parekh JK, Kosyakovsky LB, Nemeth SM, Lau ES, Januzzi JL, Wang TJ, Levy D, Ndumele CE, Selvin E  et al.  Natriuretic Peptide Cut Points for Heart Failure Classification in Individuals With and Without Obesity.  Circ Heart Fail  2025 Aug 20;:e013112. doi:10.1161/CIRCHEARTFAILURE.125.013112
  43. Hoffmann AD, Almubarak HF, Iyer R, Weinberg SE, Squires JR, Mao C, Wei J, Chaudhuri S, El-Shennawy L, Dashzeveg NK  et al.  Identification of immune signatures associated with both SARS-CoV-2 infection and lung transplantation.  Cell Rep Med  2025 Aug 19;6(8):102262. pii:102262
  44. Xian S, Grabowska ME, Kullo IJ, Luo Y, Smoller JW, Walunas TL, Wei WQ, Jarvik GP, Mooney SD, Crosslin DR  Transformer patient embedding using electronic health records enables patient stratification and progression analysis.  NPJ Digit Med  2025 Aug 14;8(1):521. pii:521
  45. Cai FY, Mao C, Luo Y  Constrained Tensor Factorization for Cancer Phenotyping and Mortality Prediction.  Stud Health Technol Inform  2025 Aug 07;329:871-875. doi:10.3233/SHTI250964
  46. Vaduganathan M, Claggett BL, Udell JA, Desai AS, Jhund PS, Henderson AD, Lay-Flurrie J, Amarante F, Glasauer A, Lam CSP  et al.  Blinded Withdrawal of Finerenone After Long-Term Treatment in the FINEARTS-HF Trial.  J Am Coll Cardiol  2025 Aug 05;86(5):396-399. doi:10.1016/j.jacc.2025.05.038
  47. Wang MC, Dolan B, Huang X, Freaney PM, Freed BH, Vega L, Markoski N, Wainright A, Kane B, Seegmiller LE  et al.  Feasibility of the Implementation of Tools for Heart Failure Risk Prediction: A Randomized Controlled Pilot Trial.  JACC Adv  2025 Aug;4(8):102004. pii:102004
  48. Luo Z, Xia M, Shi W, Zhao C, Wang J, Xin D, Dong X, Xiong Y, Zhang F, Berry K  et al.  Retraction Note: Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis.  Nature  2025 Aug;644(8075):290. doi:10.1038/s41586-025-09015-w
  49. Hourmozdi J, Easton N, Benigeri S, Thomas JD, Narang A, Ouyang D, Duffy G, Upton R, Hawkes W, Akerman A  et al.  Evaluating the Performance and Potential Bias of Predictive Models for Detection of Transthyretin Cardiac Amyloidosis.  JACC Adv  2025 Aug;4(8):101901. pii:101901
  50. Ding Y, He B, Bogush D, Schramm J, Singh C, Dovat K, Randazzo J, Tukaramrao D, Hengst J, Annageldiyev C  et al.  Critical roles of IKAROS and HDAC1 in regulation of heterochromatin and tumor suppression in T-cell acute lymphoblastic leukemia.  Leukemia  2025 Aug;39(8):2010-2020. doi:10.1038/s41375-025-02651-1

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