Northwestern University Feinberg School of Medicine
Faculty Profiles
Bruce S Bochner, MD

Bruce S Bochner, MD

Samuel M. Feinberg Professor of Medicine

Professor of Medicine (Allergy and Immunology)

 Edit My Profile

Focus of Work

Bio

My primary clinical interests are in eosinophil- and mast-cell associated diseases.

Academic Focus

My lab's primary research interest is on Siglec-8, a receptor expressed on human eosinophils and mast cells, how it signals and functions, what are its natural sialoside ligands, and whether it can be leveraged as a therapeutic target. Regarding the latter, we have generated Siglec-8 knock-in mice for preclinical studies of Siglec-8 biology and targeting in mouse models. We have also initiated studies on Siglec-6 function in human mast cells, and how pharmacologic inhibition of Bruton's tyrosi...[Read full text]My lab's primary research interest is on Siglec-8, a receptor expressed on human eosinophils and mast cells, how it signals and functions, what are its natural sialoside ligands, and whether it can be leveraged as a therapeutic target. Regarding the latter, we have generated Siglec-8 knock-in mice for preclinical studies of Siglec-8 biology and targeting in mouse models. We have also initiated studies on Siglec-6 function in human mast cells, and how pharmacologic inhibition of Bruton's tyrosine kinase (BTK) in mast cells and basophils protects from anaphylaxis in vitro and in vivo.[Shorten text]

Clinical Focus

My primary clinical interests are in eosinophil- and mast-cell associated diseases, including hypereosinophilic syndromes and systemic mastocytosis. I am also interested in anaphylaxis and other allergic diseases.

Keywords

Select a keyword to see all related Feinberg faculty via the main faculty profile site.

AllergiesAsthmaEosinophilic EsophagitisEosinophilic Gastrointestinal DiseaseFood AllergyInflammation

Education and Certification

  • MD: University of Illinois - Chicago (1982)
  • Residency: University of Illinois Medical Center, Internal Medicine (1985)
  • Fellowship: Johns Hopkins University School of Medicine, Allergy and Immunology (1988)
  • Board Certification: Allergy & Immunology, Internal Medicine

Contact

Administrative office: 312-503-0068
Clinic (for patients): 312-695-8624

McGaw Pavilion Suite M-306
240 E Huron
Chicago IL 60611

Links

Hospital Affiliations

Institutes and Centers