Northwestern University Feinberg School of Medicine
Faculty Profiles
Navdeep S Chandel, PhD

Navdeep S Chandel, PhD

David W. Cugell, MD, Professor

Professor of Medicine (Pulmonary and Critical Care) and Cell and Molecular Biology

Focus of Work

Bio

Historically, reactive oxygen species (ROS) have been thought to be cellular damaging agents, lacking a physiological function. Accumulation of ROS and oxidative damage have been linked to multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging. This guilt by association relationship left a picture of ROS as a necessary evil of oxidative metabolism, a product of an imperfect system. Yet few biological systems possess such flagrant imperfections, thanks t...[Read full text]Historically, reactive oxygen species (ROS) have been thought to be cellular damaging agents, lacking a physiological function. Accumulation of ROS and oxidative damage have been linked to multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging. This guilt by association relationship left a picture of ROS as a necessary evil of oxidative metabolism, a product of an imperfect system. Yet few biological systems possess such flagrant imperfections, thanks to the persistent optimization of evolution, and it appears that oxidative metabolism is no different. More and more evidence suggests that low levels of ROS are critical for healthy cellular function. We are testing whether mitochondrial release of H2O2 has evolved as a method of communication between mitochondrial function and other cellular processes to maintain homeostasis (e.g. stem cell function and immune responses) and promote adaptation to stress (e.g. hypoxia).[Shorten text]

Keywords


Education and Certification

  • PhD: University of Chicago, Cell Physiology (1997)

Northwestern Scholars

View the Navdeep S Chandel Northwestern Scholars profile.

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