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CHIP Projects

We have a long history of developing solutions to difficult data questions. The results of our research offer insights that can help patients and their doctors make more informed decisions.


A Chicago Center of Excellence in Learning Health Systems Research Training (ACCELERAT) was established to develop the next generation of health system transformation leaders.

All of Us

The National Institutes of Health has awarded $55 million to build the foundational partnerships and infrastructure needed to launch the Cohort Program of President Obama’s Precision Medicine Initiative (PMI)—now called All of Us.


CAPriCORN is a patient-centered outcomes and research network


Community Intervention to Reduce Cardiovascular Disease in Chicago (CIRCL-Chicago)


The Electronic Medical Records and Genomics (eMERGE) Network is a National Human Genome Research Institute (NHGRI)-funded consortium tasked with developing methods and best practices for utilization of the electronic medical record (EMR) as a tool for genomic research.


Medical Record-based Model for Understanding the INitiation of Autoimmune Events (IMMUNE) aims to test the feasibility and effectiveness of using a hybrid in silico/ in vivo (computer-simulated/ in living organism) model system, combined with machine learning strategies as a platform for understanding the etiology of autoimmune disease.


INSPIRE is a research study that supports and evaluates the implementation of screening and treatment interventions for patients with unhealthy alcohol use.

Interoperability & Standardization of Demographic Variables

In collaboration with the Pew Charitable Trusts and Regenstrief Institute, CHIP aims to identify demographic variables that are crucial for accurate patient matching and assess their current use and standardization across healthcare organizations.


Identification of Rare Autoimmune Events Following Administration of Immunotherapy Drugs (irAE-ID) is part of The National Patient-Centered Clinical Research Network (PCORnet)’s Cancer Collaborative Research Group’s initiative to stimulate collaborative projects that use PCORnet resources.

Measurement Science Program Colonoscopy Quality Improvement Sub-Project

As part of the Veteran’s Affairs (VA)s Quality Enhancement Research Initiative (QUERI), the project aims to improve veteran health by facilitating the rapid implementation of quality colonoscopy practices into routine care.


The Natural Experiments for Translation in Diabetes (NEXT-D) Study examines how the Affordable Care Act expansion of Medicaid will affect diabetes diagnosis, treatment, and outcomes among the newly enrolled.

Systemic Lupus Erythematosus (SLE) Project

The SLE (Systemic Lupus Erythematosus) Project, with funding from an NIH R21 grant, focuses on addressing the need to reduce the time it takes to identify patients with SLE.

Past Projects


ADAPTABLE (Aspirin Dosing: A Patient-centric Trial Assessing Benefits and Long-Term Effectiveness) is a study comparing the effectiveness of two daily doses of aspirin widely used to prevent heart attacks and strokes in individuals living with heart disease.


The Chicago Health Information Technology Regional Extension Center (CHITREC) originally was created in 2009 after the American Recovery and Reinvestment Act was passed.

Determinants of racial disparity

Oral anticoagulation reduces thromboembolic events associated with atrial fibrillation, yet 50% of patient with atrial fibrillation are not prescribed anticoagulants.

Great Lakes Practice Transformation Network

Healthcare is changing. The Great Lakes Practice Transformation Network (GLPTN) can help providers prepare. (GLPTN) is part of a national effort to help health care professionals – from doctors and nurses to social workers and pharmacists – coordinate care, lower costs, and improve the health of American citizens.


The HealthLNK Data Repository (HDR) provides healthcare data services to support research initiatives. It is HealthLNK’s flagship initiative that brings de-identified clinical patient data together for research.

Healthy Hearts in the Heartland (H3)

Healthy Hearts in the Heartland (H3) was a federally funded research program working with small practice clinics in Wisconsin, Illinois, and Indiana to implement and evaluate quality improvement strategies for cardiovascular care.


The Hepatitis C Community Alliance to Test and Treat (HepCATT) in Chicago targets vulnerable populations with the goal of increasing identification, treatment and cure of hepatitis C (HCV) infection.

High-throughput Phenotyping on EHRs Using Multi-Tensor Factorization

Various efforts have been undertaken to transform diverse and voluminous electronic health record (EHR) data into concise and meaningful concepts, or phenotypes.

Illinois Medicaid Promoting Interoperability Help Desk

The Illinois Department of Healthcare and Family Services (HFS) contracted with the Chicago Health IT Regional Extension Center (CHITREC), a program of CHIP, and the Illinois Health IT Regional Extension Center (ILHITREC) to provide education and outreach for the Illinois Medicaid Promoting Interoperability program to support eligible healthcare provider enrollment and progression through the program.

Phenotype Modeling and Execution Architecture

A new era of individualized medicine is evolving where novel biomedical discoveries are leading to more effective prevention, treatment, and diagnosis of disease.

Provider Compliance to the 2017 Hypertension Treatment Guideline and Patients’ Trajectory of Blood Pressure

The 2017 hypertension treatment guideline changed the definition of uncontrolled blood pressure (BP) to ≥130/80 mm Hg (from ≥140/90) and BP threshold for the initiation of antihypertensive medication for patients at higher risk of cardiovascular events.

Quality Payment Program

The Centers for Medicare & Medicaid Services (CMS) awarded a contract to Altarum Institute to help small practices in Michigan, Ohio, Indiana, Illinois, Kentucky, Wisconsin, and Minnesota prepare for and participate in the Quality Payment Program, established by the Medicare Access and Children’s Health Insurance Program Reauthorization Act of 2015 (MACRA).

Surveillance on Anticoagulants Prescription, Risk of Stroke and Bleeding by Geographic Region and Race in the US

Oral anticoagulation (OAC) therapy reduces the risk of thromboembolic events associated with atrial fibrillation (AF), yet a substantial proportion of patients with AF are not prescribed OAC.

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