Northwestern University Feinberg School of Medicine
Faculty Profiles
Gabriel J Rocklin, PhD

Gabriel J Rocklin, PhD

Assistant Professor of Pharmacology

Focus of Work

Bio

Faculty Member, Center for Synthetic Biology

We develop high-throughput methods for protein biophysics and protein design, with a focus on protein therapeutics. Key questions include: How do protein sequence and structure determine folding stability, conformational dynamics, and resistance to aggregation/degradation-inducing stresses? Can we quantitatively predict these protein "phenotypes" from genotype (sequence) using computational modeling? How do we design protein therapeutics that optimiz...[Read full text]
Faculty Member, Center for Synthetic Biology

We develop high-throughput methods for protein biophysics and protein design, with a focus on protein therapeutics. Key questions include: How do protein sequence and structure determine folding stability, conformational dynamics, and resistance to aggregation/degradation-inducing stresses? Can we quantitatively predict these protein "phenotypes" from genotype (sequence) using computational modeling? How do we design protein therapeutics that optimize these phenotypes for a particular application? To answer these questions, we combine large-scale de novo computational protein design with high-throughput methods such as display selections, mass spectrometry proteomics, and next-generation sequencing, enabling us to test thousands of proteins in parallel. By combining these technologies, we seek to develop efficient "design-test-analyze" cycles, iterating our way to an improved, quantitative understanding of protein biophysics and more advanced protein therapeutics.[Shorten text]

Keywords


Education and Certification

  • PhD: University Of California-San Francisco, Biophysics (2013)
  • Postdoctoral Fellowship: University of Washington, Institute for Protein Design (2019)

Contact

312/503-4892

Searle Building 5-568
320 E Superior
Chicago IL 60611

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