Northwestern University Feinberg School of Medicine
Faculty Profiles
Clara Bien Peek, PhD

Clara Bien Peek, PhD

Assistant Professor of Biochemistry and Molecular Genetics and Medicine (Endocrinology)

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Focus of Work

Bio

Epidemiological and genetic studies have shown that disruption of the circadian clock is a factor in multiple pathologies, including metabolic disease, myopathy, and cancer. Our laboratory aims to uncover the physiological impact of the circadian clock on nutrient-responsive regulatory pathways, including oxygen-sensing transcriptional networks. Indeed, we have recently identified a key connection between skeletal muscle clocks and the hypoxia-inducible factor (HIF) pathway, which drives circadi...[Read full text]Epidemiological and genetic studies have shown that disruption of the circadian clock is a factor in multiple pathologies, including metabolic disease, myopathy, and cancer. Our laboratory aims to uncover the physiological impact of the circadian clock on nutrient-responsive regulatory pathways, including oxygen-sensing transcriptional networks. Indeed, we have recently identified a key connection between skeletal muscle clocks and the hypoxia-inducible factor (HIF) pathway, which drives circadian control of the hypoxic response and glucose metabolism. The goal of our laboratory is to understand the interplay between hypoxic and circadian transcriptional pathways both at the genomic and nutrient-signaling levels, and to apply these findings to understand the role of circadian clocks in metabolic diseases such as type-2 diabetes and cancer.[Shorten text]

Education and Certification

  • PhD: Johns Hopkins University, Biochemistry, Cellular and Molecular Biology (2010)
  • Postdoctoral Fellowship: Northwestern University Feinberg School of Medicine, Endocrinology and Molecular Metabolism (2015)

Contact

312-503-6973

Morton Building Room 7-605
310 E Superior
Chicago IL 60611

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