Northwestern University Feinberg School of Medicine
Faculty Profiles
William A Muller, MD, PhD

William A Muller, MD, PhD

Professor of Pathology

Focus of Work

Bio

My lab studies the inflammatory response at the cellular and molecular level. We are focused on the process of diapedesis, the "point of no return" in inflammation where leukocytes squeeze between tightly apposed endothelial cells to enter the site of inflammation. We have identified and cloned several molecules that are critical to the process of diapedesis (PECAM (CD31), CD99, and VE-cadherin) and are studying how they regulate the inflammatory response using in vitro and in vivo models. We...[Read full text]My lab studies the inflammatory response at the cellular and molecular level. We are focused on the process of diapedesis, the "point of no return" in inflammation where leukocytes squeeze between tightly apposed endothelial cells to enter the site of inflammation. We have identified and cloned several molecules that are critical to the process of diapedesis (PECAM (CD31), CD99, and VE-cadherin) and are studying how they regulate the inflammatory response using in vitro and in vivo models. We have recently described the Lateral Border Recycling Compartment, a novel para-junctional organelle that contains PECAM and CD99 and is critical for diapedesis to occur. We are currently investigating how this compartment regulates diapedesis in the hope of finding novel targets for anti-inflammatory therapy.[Shorten text]

Keywords


Education and Certification

  • PhD: Rockefeller U (1981)
  • MD: Cornell U Medical Ca (1982)
  • Internship: Massachusetts General Hospital (1983)
  • Residency: Brigham & Women's Hospital (1987)
  • Board Certification: Anatomic Pathology