Physical Medicine and Rehabilitation PSTP Scholars
Ishan Roy, MD, PhD
BS: Case Western Reserve University
MD: Medical College of Wisconsin
PhD: Medical College of Wisconsin
Subspecialty interest: Cancer Rehabilitation
I completed my PhD in the laboratory of Dr. Michael Dwinell at the Medical College of Wisconsin. In the Dwinell lab, I investigated the role of chemokines in the pathogenesis of pancreatic cancer. Through expression analysis of human tissues, and using a variety of mouse models, I helped to delineate novel roles for chemokines in the regulation of pancreatic cancer cell metastasis and tumor microenvironment dynamics. As chemokines are important regulators of cell motility, a significant portion of my dissertation work focused on understanding the mechanisms by which chemokines influence cancer cell signaling through their g-protein coupled receptors. My dissertation work culminated with discovery of a possible mechanism for pancreatic cell motility that is regulated by bio-energetic signaling.
My current basic science research interests stem from my prior work in bioenergetic signaling. Specifically, I am interested in understanding more about how cancer, and its various treatments, influence systemic metabolism. Moving forward, I would like to investigate the mechanisms underlying cancer related cachexia and sarcopenia. From a clinical and translational perspective, I am interested in understanding how cancer rehabilitation can treat cancer related debility, using more novel physical exercise/therapy regimens and novel pharmaceutical targeting.
Colin K Franz, MD, PhD
PhD: Dalhousie University, Canada
MD: University of Calgary Faculty of Medicine, Canada
R. James Cotton, MD, PhD
BA: Rice University
BS: Rice University
PhD: Baylor College of Medicine
MD: Baylor College of Medicine