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Physical Medicine and Rehabilitation PSTP Scholars

Current Scholars

Ishan Roy, MD, PhD

Ishan Roy, MD, PhD

Education

BS: Case Western Reserve University

MD: Medical College of Wisconsin

PhD: Medical College of Wisconsin

Subspecialty interest: Cancer Rehabilitation

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Research Interests:

I completed my PhD in the laboratory of Dr. Michael Dwinell at the Medical College of Wisconsin. In the Dwinell lab, I investigated the role of chemokines in the pathogenesis of pancreatic cancer. Through expression analysis of human tissues, and using a variety of mouse models, I helped to delineate novel roles for chemokines in the regulation of pancreatic cancer cell metastasis and tumor microenvironment dynamics. As chemokines are important regulators of cell motility, a significant portion of my dissertation work focused on understanding the mechanisms by which chemokines influence cancer cell signaling through their g-protein coupled receptors. My dissertation work culminated with discovery of a possible mechanism for pancreatic cell motility that is regulated by bio-energetic signaling.

My current basic science research interests stem from my prior work in bioenergetic signaling. Specifically, I am interested in understanding more about how cancer, and its various treatments, influence systemic metabolism. Moving forward, I would like to investigate the mechanisms underlying cancer related cachexia and sarcopenia. From a clinical and translational perspective, I am interested in understanding how cancer rehabilitation can treat cancer related debility, using more novel physical exercise/therapy regimens and novel pharmaceutical targeting.

Past Scholars

Colin K Franz, MD, PhD

Education

PhD: Dalhousie University, Canada

MD: University of Calgary Faculty of Medicine, Canada

R. James Cotton, MD, PhD

Education

BA: Rice University

BS: Rice University

PhD: Baylor College of Medicine

MD: Baylor College of Medicine

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Research Interests:

My graduate work involved developing techniques for rapid three-dimensional two-photon imaging from the brain in order to record the activity of large populations of neurons. I am now a resident at Shirley Ryan Ability Lab, formerly RIC, and am studying the application of biofeedback to enhance neuroplasticity in spinal cord injury. My long-term interest is neural-interface technologies to help people with disabilities.