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Recent Publications

Browse recent studies from the Lou and Jean Malnati Brain Tumor Institute to learn more about our cutting-edge research.

  1. Zhu L, Kinjawadekar I, Prempeh C, Nikonorova IA, Mirek ET, Lopez EM, Jonsson WO, Levy JL, Wang L, Li X  et al.  A metabolic basis for motor deficits in mice lacking BCKDK.  J Nutr Biochem  2026 Jun;152:110275. doi:10.1016/j.jnutbio.2026.110275
  2. Luo M, Wu S, Huang C, Zheng Z, Xia Q, Li Y, Zhou X, Hong S, Zhong R, Li W  et al.  Inhibition of PRMT5-dependent YAP methylation attenuates tumorigenicity and radioresistance in glioblastoma.  Cancer Lett  2026 Apr 28;644:218308. doi:10.1016/j.canlet.2026.218308
  3. Smith HL, Duckett DJ, Mejia-Bautista M, Alshawa A, Jamshidi P, Castellani RJ, Lukas RV, Chandler JP, Jennings LJ, Santana-Santos L  et al.  IDH-wildtype astrocytoma with FH mutation, epigenetic similarity to IDH-mutant astrocytoma, and hypermethylation of CDKN2A arising in the brainstem.  J Neuropathol Exp Neurol  2026 Apr 01;85(4):398-401. doi:10.1093/jnen/nlaf086
  4. Billingham LK, DeLay SL, Eshac Y, Chia TY, Tripathi S, Olson IE, Zilinger K, Subbiah J, Wang Z, Sadagopan NS  et al.  Microglial fructose metabolism is essential for glioblastoma growth.  Proc Natl Acad Sci U S A  2026 Mar 24;123(12):e2521256123. pii:e2521256123
  5. Lukas RV, Du R, Congivaram H, McCortney K, Dixit K, Horbinski C, Schwartz M, Lezon R, Singer L, Primdahl D  et al.  Consideration of spatial companion biomarkers for targeted therapeutics in cancer: depatuxizumab mafodotin in glioblastoma.  JCI Insight  2026 Mar 23;11(6). pii:e198475
  6. Song R, Dapash M, Jamshidi P, Gondi V, Lukas RV, Khan OH  Survival and function in elderly patients with GBM: the role of surgical resection with contemporary multimodal therapy.  J Neurooncol  2026 Mar 17;177(2). pii:62
  7. Khalilullah T, Yang X, Yao J, Ghaith AK, Khalifeh JM, Azad TD, Ahmed AK, Xia Y, Theodore N, Romo CG  et al.  Malignant peripheral nerve sheath tumors arising in SMARCB1-associated schwannomatosis: illustrative cases.  J Neurosurg Case Lessons  2026 Mar 16;11(11). pii:CASE25610
  8. Colman H, Lombardi G, Wong ET, Walbert T, Eoli M, Lassman AB, Peereboom DM, Kizilbash SH, Kamiya-Matsuoka C, Pitz MW  et al.  STELLAR: Phase III, Randomized, Open-Label Study of Eflornithine Plus Lomustine Versus Lomustine Alone in Patients With Recurrent Grade 3 Astrocytoma.  J Clin Oncol  2026 Mar 10;44(8):641-652. doi:10.1200/JCO-25-01204
  9. Jin Z, Li X, Hou X, Hu J, Zhuo Y, Shi J, Xu T, Zhao Q, Jing Z  Correction: Single-atom Ca nanozyme induces glioma death through Ca2+-overload-enhanced catalytic tumor nanotherapy, ferroptosis and synergistic remodeling of the immune microenvironment.  J Nanobiotechnology  2026 Mar 02;24(1). pii:205
  10. Lee-Chang C  Organized immunity in the CNS: what stroke reveals about neuroinflammation and lymphoid niches.  J Clin Invest  2026 Mar 02;136(5). pii:e202688
  11. Khasraw M, Pristo E, Stupp R  20 years of the Stupp protocol: confronting stagnation in glioblastoma therapy.  Lancet Oncol  2026 Mar;27(3):277-280. doi:10.1016/S1470-2045(25)00705-3
  12. Wu R, Yu X, Song X, He Q, Walker M, Sisbarro D, Horbinski C, Tiek D, Hu B, Zhang N  et al.  Tumor-associated astrocytes augment cholesterol synthesis to support glioblastoma growth through alternatively spliced Quaking (QKI) isoforms.  Neuro Oncol  2026 Feb 17;. pii:noag030
  13. Rajan A, Castro FR, de Godoy LL, Hanaoka M, Turk S, Desiderio L, Stupp R, Mohan S, Chawla S  Imaging Biomarkers for Detecting IDH-mutations and Monitoring Response to Novel Targeted Therapies: Current Insights and Future Perspectives.  Neuro Oncol  2026 Feb 16;. pii:noag028
  14. Tripathi S, Najem H, Hurley L, Du R, Dmello C, Ali H, McCortney K, Habashy KJ, Zhang P, Horbinski CM  et al.  STING-induced blood-brain barrier opening combined with radiotherapy potentiates antitumor response in a high-grade glioma model.  J Clin Invest  2026 Feb 16;136(4). pii:e198843
  15. Padilla F, Arvanitis C, Bollard CM, Gallus M, De Groot J, Klein RS, Ransohoff RM, Sonabend AM, Okada H  Focused ultrasound-enhanced cell therapy for brain tumors: Summary of roundtable discussions.  Neurooncol Adv  2026;8(1):vdag026. pii:vdag026
  16. Youngblood MW, Tripathi S, Najem H, Congivaram H, Gomez M, Sears TK, Hurley L, Billingham LK, Silvers C, Wang W  et al.  STING activation induces cytotoxic and immune responses in meningiomas via inflammatory cell death pathways.  Nat Commun  2026 Feb 12;17(1). pii:2685
  17. Fei-Zhang DJ, Lutfallah SC, Mensah J, Chelius DC, Ruff MW, Dixit K, Paludo J, Smith SS, Patel UA, D'Souza JN  et al.  Assessments of social vulnerability on central nervous system cancer disparities in the United States.  Commun Med (Lond)  2026 Feb 10;6(1). pii:153
  18. Asogwa OA, Dirven L, Aaronson NK, Baumert BG, van den Bent M, Brandes AA, Clement PM, Coens C, Chinot O, Gorlia T  et al.  Age and sex as risk factors for health-related quality of life outcomes in patients with glioma: a CODAGLIO 2.0 analysis.  Oncologist  2026 Feb 05;31(3). pii:oyag005
  19. Lindsay H, Du Y, Qi L, Zhang H, Zhao S, Braun FK, Kogiso M, Stephan C, Alton G, Stein G  et al.  Targeting Pediatric Glioblastomas by Combining OLIG2 Inhibitor CT-179 with Fractionated Radiation in a Panel of Patient-Derived Orthotopic Xenograft Mouse Models.  Int J Mol Sci  2026 Feb 04;27(3). pii:1543
  20. Li X, Han Z, Sun S, Wu Y, Zhang X, Yin Y, Zhao Z, Hai J, Wang B  Chiral Cascade-Targeted Nanoassembly Eradicates Intratumoral Bacteria via Ferroptosis to Potentiate STING-Driven Antitumor Immunity.  ACS Appl Mater Interfaces  2026 Feb 04;18(4):6610-6625. doi:10.1021/acsami.5c24093
  21. Lukas RV, Cannon A, Chittiboina P, Vasudevan HN, Blakeley JO, Hirbe AC  Neurogenetic tumor syndromes: The current landscape of workup and treatment.  Neurooncol Pract  2026 Feb;13(1):14-22. doi:10.1093/nop/npaf089
  22. Lalchungnunga H, Dampier CH, Singh O, Hoang DT, Shulman ED, Abdullaev Z, Li B, Luo Z, Wu Z, Pearce TM  et al.  Classification accuracy of a hierarchical molecular inference-based deep-learning system for CNS tumour diagnosis: a multi-institutional, retrospective study.  Lancet Oncol  2026 Feb;27(2):243-253. doi:10.1016/S1470-2045(25)00661-8
  23. Arrieta VA, Benotmane JK, Du R, Habashy KJ, Zhao J, Najem H, Wang S, Hou D, Katz JL, Vázquez-Cervantes GI  et al.  Integrated immune profiling of chordomas reveals spatially organized niches and functional heterogeneity.  Neuro Oncol  2026 Feb 01;28(2):440-453. doi:10.1093/neuonc/noaf213
  24. Budhiraja S, Faisal UH, Baisiwala S, Chojak R, Koutah L, Drewes NB, Cho S, Kazi HA, Chen R, Perrault EN  et al.  THOC1 complexes with SIN3A to regulate R-loops and promote glioblastoma progression.  Neoplasia  2026 Feb;72:101271. pii:101271
  25. Goerzen D, Kim M, Schroff C, Hoang MN, Wollowitz JS, Kolb A, Walshon JP, McCortney K, Horbinski C, Galbraith K  et al.  Machine perception liquid biopsy identifies brain tumours via systemic immune and tumour microenvironment signature.  Nat Nanotechnol  2026 Feb;21(2):277-287. doi:10.1038/s41565-025-02080-2
  26. Cherng HR, Sun K, Bentzen SM, Brown PD, Armstrong TS, Palmer JD, Gondi V, Mehta MP, Mishra MV  Redefining neurocognitive outcomes after radiation for brain metastases: a patient-level meta-analysis of recovery following initial decline.  J Natl Cancer Inst  2026 Feb 01;118(2):269-275. doi:10.1093/jnci/djaf264
  27. Mehta MP, Gondi V, Ahluwalia MS, Roberge D, Sio TTW, Trifiletti DM, Muanza T, Krpan AM, Zhu Z, Ramakrishna NR  et al.  Tumor Treating Fields Therapy After Stereotactic Radiosurgery for Brain Metastases From Non-Small Cell Lung Cancer: Final Results of the Phase 3 METIS Study.  Int J Radiat Oncol Biol Phys  2026 Feb 01;124(2):278-293. doi:10.1016/j.ijrobp.2025.08.066
  28. Dixit KS, Kumthekar P, Lukas RV, Williams A, Tate MC, Chandler JP, Jamshidi P, Helenowski I, Zhang H, Bloch O  et al.  A phase 2, open label, clinical trial of pre-surgical and adjuvant treatment of recurrent glioblastoma with tremelimumab and durvalumab alone and in combination.  J Neurooncol  2026 Jan 28;176(3):185. doi:10.1007/s11060-026-05446-1
  29. LaBella D, Schumacher K, Mix M, Leu K, McBurney-Lin S, Nedelec P, Villanueva-Meyer J, Raleigh DR, Shapey J, Vercauteren T  et al.  The 2024 Brain Tumor Segmentation Challenge Meningioma Radiotherapy (BraTS-MEN-RT) dataset.  Sci Data  2026 Jan 27;13(1). pii:306
  30. Pan T, Shiau CK, Lu L, Wang C, Wang M, He Y, Bhimaraj A, Brat D, Huse J, Jessica Li J  et al.  Hypatia: Comparative Isoform Profiling Across Cell Populations from Long-Read Single-Cell Transcriptomes.  bioRxiv  2026 Jan 25;. pii:2026.01.13.699341
  31. Lassman AB, Polley MC, Iwamoto FM, Gondi V, Sulman EP, Wolchok JD, Mehta MP  Reply to: Blood-Brain Barrier Heterogeneity in NRG BN007: Implications for Immunotherapy Delivery.  J Clin Oncol  2026 Jan 16;:JCO2502821. doi:10.1200/JCO-25-02821
  32. Jones G, Murphy A, Lee-Chang C  B cell immunity and therapeutic opportunities in brain metastases.  Front Immunol  2025;16:1740386. pii:1740386
  33. Khan F, Petrosyan E, Liu Y, Bahrami A, Taefi E, Geula C, Lesniak MS, Chen P  Microglial TBK1 Signaling Promotes Breast Cancer Brain Metastasis.  Cancer Res  2026 Jan 02;86(1):12-21. doi:10.1158/0008-5472.CAN-25-1791
  34. Pendyala P, Ufondu A, Gondi V  Innovations in Whole Brain Radiation Therapy.  Cancer J  ;32(1). pii:e0810
  35. Trautmann RK, Dennison N, McCortney K, Klier S, Cosacak MI, Werner C, Akyoldas G, Horbinski CM, Freudenberg U, Kizil C  High-Throughput 3D Glioblastoma Model in Glycosaminoglycan Hydrogels for Personalized Therapeutic Screening.  Macromol Biosci  2026 Jan;26(1):e00394. pii:e00394
  36. Wu M, Yang Y, Zhang J, Efimov AI, Li X, Zhang K, Wang Y, Bodkin KL, Riahi M, Gu J  et al.  Patterned wireless transcranial optogenetics generates artificial perception.  Nat Neurosci  2026 Jan;29(1):234-245. doi:10.1038/s41593-025-02127-6
  37. Li J, Ross JL, Hambardzumyan D, Brat DJ  Immunopathology of Glioblastoma.  Annu Rev Pathol  2026 Jan;21(1):135-162. doi:10.1146/annurev-pathmechdis-042524-025950
  38. Ali H, Zhou N, Chen L, van Hijfte L, Tulaiha R, Karri V, Zhou Y, Habashy K, Arrieta VA, Kim KS  et al.  YBX1&YBX3 as novel targets to potentiate immune checkpoint blockade response in gliomas.  Neuro Oncol  2026 Jan 01;28(1):159-174. doi:10.1093/neuonc/noaf227
  39. He Z, Li W, Liu T, Li X, Han J, Zhang T, Yuan Y  GAGM: Geometry-aware graph matching framework for weakly supervised gyral hinge correspondence.  Med Image Anal  2026 Jan;107(Pt A):103820. doi:10.1016/j.media.2025.103820
  40. Aggarwal A, Youngblood MW, Picart T, Najem H, Oten S, Cady MA, Magill ST, Horbinkski CM, Chandler JP, Heimberger AB  et al.  Meningioma cell reprogramming and microenvironment interactions underlie brain invasion.  Neuro Oncol  2025 Dec 31;. pii:noaf292
  41. Duckett D, Santana-Santos L, McCord M, Smith V, Lopes MBS, Youngblood MW, Magill ST, Chandler JP, Heimberger AB, Lukas R  et al.  Development, validation, and utility of a clinically applicable methylation classifier for recurrence risk prediction in meningiomas.  Acta Neuropathol Commun  2025 Dec 29;13(1):259. pii:259
  42. Olson IE, Chojak R, Faisal UH, Turunen J, Lazanyi I, Miska J, Ahmed AU  Use of Cerebral Open-Flow Microperfusion for the Longitudinal Collection of Interstitial Fluid in an Animal Model of Glioblastoma.  J Vis Exp  2025 Dec 23;(226). doi:10.3791/68748
  43. Amirkhani N, Maroufi F, Pour-Rashidi A, Shirani M, Chandler JP  Impact of anti-seizure medication duration on postoperative seizures following supratentorial high-grade glioma resection: a mixed-model and tree-based approach.  J Neurooncol  2025 Dec 23;176(2):134. doi:10.1007/s11060-025-05373-7
  44. Tomita Y, Link G, Ge Y, Gold ERH, Racanelli A, Cardona HJ, Romero M, Gadd S, Watanabe J, Uchida E  et al.  Effects of combination therapy of a CDK4/6 and MEK inhibitor in diffuse midline glioma preclinical models.  PLoS One  2025;20(12):e0323235. pii:e0323235
  45. Visa MA, Liggett MR, Lashley S, Bhatti U, Dawood ZA, Anand A, Gill NP, Scholtens DM, Wang B, Alam HB  Valproic acid for treatment of traumatic brain injury: Study protocol for the VIBRANT prospective randomized trial.  Transfusion  2025 Dec 20;. doi:10.1111/trf.70029
  46. Aucoin L, Templer JW, Tate MC, Dixit KS  The role of a multidisciplinary clinic for management of patients with IDH mutant gliomas.  Front Oncol  2025;15:1729589. pii:1729589
  47. Youngblood MW, Kumari A, Kang YT, Gould A, Habashy K, Gomez M, Lingamarla H, Morey T, Chen L, Congivaram H  et al.  Dynamic release of extracellular particles after opening of the blood-brain barrier predicts glioblastoma susceptibility to paclitaxel.  Nat Commun  2025 Dec 16;16(1):11045. pii:11045
  48. Li Y, Sheng M, Li W, Liu S, Wang B, Liu B, Luo M, Zhou X, Xia Q, Hong S  et al.  Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity.  Nat Commun  2025 Dec 13;17(1):440. pii:440
  49. Song X, Tiek D, Lu M, Yu X, Wu R, Walker M, He Q, Sisbarro D, Hu B, Cheng SY  A single-cell atlas of RNA alternative splicing in the glioma-immune ecosystem.  Genome Biol  2025 Dec 12;26(1):426. pii:426
  50. Nguyen TH, Nguyen HT, Vu V, Lam BT, Huynh P, Wang T, Li X, Bagci U, Xu M  DuetMatch: Harmonizing semi-supervised brain MRI segmentation via decoupled branch optimization.  Comput Med Imaging Graph  2025 Dec;126:102666. doi:10.1016/j.compmedimag.2025.102666
These are the publications from our team members that have been most recently indexed by PubMed. Visit PubMed to see more of our publications.

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