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Recent Publications

Browse recent studies from the Lou and Jean Malnati Brain Tumor Institute to learn more about our cutting-edge research.

  1. Song R, Liu L, Ofori-Apau J, Hojo E, Mirza M, Huston J, Gondi V, Khan OH  The clinical utility of magnetic resonance elastography in differentiating tumor recurrence from pseudoprogression in glioblastoma.  Magn Reson Imaging  2026 Nov;133:110746. doi:10.1016/j.mri.2026.110746
  2. Tiwari A, Pawlowski KD, Balyasnikova IV  Improving T-cell engager efficacy in glioblastoma with multi-antigen targeting and novel delivery approaches.  Acta Neuropathol  2026 Aug 03;152(1). pii:15
  3. Huang Z, Jiang T, Suarez Palacios MM, Ouyang T, Abdallah A, Niu L, Chen J, Zhai X, Ciolak E, Qiang W  et al.  Therapy-Associated Lineage Plasticity in DIPG Following Combined CDK4/6 Inhibitor, Temozolomide, and Radiation.  Cancer Lett  2026 Jul 30;:218771. doi:10.1016/j.canlet.2026.218771
  4. Chojak R, Drewes NB, Slychan K, Lukas RV  Spatial patterns of progression in reported glioblastoma cohorts after upfront chemoradiation and salvage therapy: a systematic review and meta-analysis.  J Neurooncol  2026 Jul 30;179(1). pii:20
  5. Xia Y, Papali P, Al-Mistarehi AH, Meyer C, Gross J, Khan M, Bettegowda C, Witham T, Bydon A, Theodore N  et al.  Detailing long-term functional morbidity after resecting mobile spine chordomas across 35 patients.  J Neurosurg Spine  2026 Jul 24;:1-10. doi:10.3171/2026.2.SPINE251166
  6. Walker MN, Tang H, Silvers C, Roth S, Tiek D, Hu B, Cheng SY, Song X  iPSC-Derived Microglia-like Cells Exhibit Protocol-Dependent Transcriptomic Features and Robust Phagocytosis of Glioma Cells.  bioRxiv  2026 Jul 22;. pii:2026.07.21.739939
  7. Li X, Zhao D, Jia X, Du G, Xu J, Qi Y, Chen Y, Wu Y, Gu J, Zhu J  et al.  Deciphering spatial heterogeneity by multimodal spatial transcriptomics modelling with SpatialModal.  Bioinformatics  2026 Jul 21;. pii:btag540
  8. Rashidi AP, Perronne L, Krumpelman C, Hill V, Borhani AA, Subedi K, Kelahan L, Avery R, Savas H, Rusinak D  et al.  Physics-Informed Multiscale Decoding of Tissue Microstructure: The Gray Level Affinity Metrics (GLAM) Framework.  J Imaging Inform Med  2026 Jul 20;. doi:10.1007/s10278-026-02132-6
  9. Li J, Wang X, Tong L, Feng B, Shih LK, Markwell SM, Nuszen H, Gruchala T, Lam NG, Basakis P  et al.  The perinecrotic niche of glioblastoma drives tumor-associated macrophage polarization and immunosuppression via podoplanin-mediated CLEC5A activation.  J Clin Invest  2026 Jul 15;136(14). pii:e199228
  10. Huang S, Lian Z, Jia D, Sun K, Li X, Liu J, Wang Y, Jiang C, Zhu F, Ding Z  et al.  BrainSeg: a generalized framework for comprehensive multimodal brain tissue segmentation, parcellation, and lesion labeling.  NPJ Digit Med  2026 Jul 10;. doi:10.1038/s41746-026-02894-x
  11. Radaelli S, Frezza AM, Fossati P, Baldi GG, Akiyama T, Asencio JM, Bolle S, Bovee JVMG, Caraceni AT, Cote GM  et al.  Global Consensus on the Management of Primary Localized Chordoma.  JAMA Oncol  2026 Jul 09;. doi:10.1001/jamaoncol.2026.2054
  12. Eshac Y, Cabang J, Miska J  The brain's sweet spot: why microglia can run on fructose metabolism.  Front Immunol  2026;17:1864729. pii:1864729
  13. Baumert BG, Hegi ME, van den Bent MJ, von Deimling A, Gorlia T, Hoang-Xuan K, Brandes AA, Sargos P, Taphoorn MJB, Vauleon E  et al.  Temozolomide Versus Radiotherapy as First-Line Therapy for Low-Grade Glioma: Mature Results of a Randomized Phase III Trial (EORTC 22033-26033/NCIC-CTG/TROG/MRC-CTU).  J Clin Oncol  2026 Jul 02;:JCO2502735. doi:10.1200/JCO-25-02735
  14. Singh R, Koempel A, French B, Crawford C, Perlow HK, Rauh S, Kutuk T, Beyer S, Grecula J, Blakaj D  et al.  Improved Progression-Free Survival Following Dose-Escalated Versus Standard-Dose Postoperative Radiation Therapy for High-Risk Meningiomas: An International Multicenter Individual Patient-Level Meta-Analysis (FIRESTORM).  Int J Radiat Oncol Biol Phys  2026 Jul 01;125(3):696-705. doi:10.1016/j.ijrobp.2026.03.036
  15. Weber-Levine C, Xia Y, Al-Mistarehi AH, Jiang K, Mendelson BZ, Antar A, Ksabi NL, Zaitoun KJ, Papali P, Neerumalla S  et al.  The Impact of Expansile Duraplasty After Resection of Intramedullary Astrocytomas.  Oper Neurosurg  2026 Jul 01;31(1):36-49. doi:10.1227/ons.0000000000001762
  16. Kim KS, Zhang J, Arrieta VA, Dmello C, Grabis E, Yabo YA, Wang S, Habashy K, Duffy J, Zhao J  et al.  Glioma-intrinsic MAPK/ERK signaling promotes immunotherapy efficacy through T cell infiltration and interferon responses.  Nat Commun  2026 Jun 25;17(1). pii:7968
  17. Ozer BH, Lindhorst SM, Merrell RT, Trevino CR, Rudnick JD, Avgeropoulos NG, Ramakrishna N, Khagi S, Rauf Y, Walbert T  et al.  Pembrolizumab, Temozolomide and HSPPC-96 Vaccine in Newly Diagnosed Glioblastoma Post-Chemoradiation: Results from a Multi-institutional, Phase 2, Randomized, Placebo-Controlled Trial.  medRxiv  2026 Jun 24;. pii:2026.06.22.26354817
  18. Walker MN, Hu B, Cheng SY, Song X  Stepwise Protocol for Alternative Splicing Analysis in Single-Cell SMART-Seq2 RNA-Seq Data.  Bio Protoc  2026 Jun 20;16(12):e5735. pii:e5735
  19. Nathan CL, Ghandour D, Cunningham EM, Lukas RV, Sullivan J, Sachdev S, Templer JW  Epilepsy characteristics and outcomes in patients with pleomorphic xanthoastrocytomas.  J Neurooncol  2026 Jun 19;178(3). pii:72
  20. Mooney R, Ngai G, Kaur G, Kang EY, Lara J, Abd El-Fattah EE, Huang P, Flores L, McDonald M, Talley M  et al.  Neural stem cell delivery of oncolytic CRAd-S-pk7 immunotherapy for stage 3 ovarian cancer: Dose-regimen studies.  Mol Ther Oncol  2026 Jun 18;34(2):201219. pii:201219
  21. Fares J, Ahrendsen JT, Congivaram HT, Santana-Santos L, Oyon D, Dixit K, Youngblood MW, Chandler JP  CLIP2::MET fusion identifies a molecularly distinct glioneuronal tumor.  Discov Oncol  2026 Jun 17;. doi:10.1007/s12672-026-05421-2
  22. Li X, Xu J, Du G, Jia X, Zhao D, Zhou C, Xiao K, Gu J, Zhu J, Shang X  Accurately Deciphering Tissue Heterogeneity From Spatial Multi-Modal and Multi-Omics With STransformer.  Adv Sci (Weinh)  2026 Jun 09;:e75969. pii:e75969
  23. Khalifeh JM, ElNemer W, Ghaith AK, Khalilullah T, Rajasekaran J, Xia Y, Ahmed AK, Azad TD, Yang L, Al-Mistarehi AH  et al.  Surgical Management of Spinal Chondrosarcoma: Retrospective Case Series and Systematic Review of the Literature.  Oper Neurosurg  2026 Jun 03;. doi:10.1227/ons.0000000000002086
  24. Habashy KJ, Arrieta VA, Haupt B, Gómez M, El-Hajj VG, Kim KS, Dmello C, Chen L, Carpentier A, Canney M  et al.  Development of skull-implanted ultrasound for blood-brain barrier opening and drug delivery in neuro-oncology.  Neurooncol Adv  2026 Jun;8(Suppl 4):iv9-iv19. doi:10.1093/noajnl/vdaf044
  25. Mejia-Bautista M, Loxas M, Jamshidi P, Duckett D, Wolinsky JP, Ahrendsen JT  A 40-year-old woman with a spinal mass.  Brain Pathol  2026 Jun 01;:e70111. doi:10.1111/bpa.70111
  26. Duffy JT, Martin-Regalado A, Haupt BE, Pogue JR, Thakur A, Cota MF, Zannikou M, Misener S, Krymskaya VP, McCortney K  et al.  Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors.  Adv Sci (Weinh)  2026 Jun;13(35):e22391. pii:e22391
  27. Zhu L, Kinjawadekar I, Prempeh C, Nikonorova IA, Mirek ET, Lopez EM, Jonsson WO, Levy JL, Wang L, Li X  et al.  A metabolic basis for motor deficits in mice lacking BCKDK.  J Nutr Biochem  2026 Jun;152:110275. doi:10.1016/j.jnutbio.2026.110275
  28. Wang Y, Belakhoua S, Yang Y, Serrano J, Horbinski C, Boué DR, DeWitt JC, Liechty B, McGuone D, Mao Q  et al.  Histopathological and molecular heterogeneity of dysembryoplastic neuroepithelial tumors.  J Neuropathol Exp Neurol  2026 May 29;. pii:nlag052
  29. Piña Y, Umeh Garcia M, Boire A, Brenner A, Camidge DR, Chang S, Forsyth PA, Hayden Gephart M, Olayinka Kamson D, Kumthekar P  et al.  Breaking Barriers in Leptomeningeal Disease: A SNO-ASCO Consensus Review on Clinical Trial Design and Basic Science Integration.  Neuro Oncol  2026 May 27;. pii:noag126
  30. Lukas RV, Zhai L, Lauing KL, Kim M, Koch T, Penco-Campillo M, Bommi P, Dixit K, Kumthekar P, Sharp L  et al.  Phase 1 evaluation of patients with newly diagnosed glioblastoma treated with radiation, nivolumab, and IDO1 enzyme inhibitor BMS-986205.  Clin Cancer Res  2026 May 26;. doi:10.1158/1078-0432.CCR-26-1124
  31. Kundu IG, Toro N, Mochizuki AY, Langhnoja J, Ayyagari RV, Cronk JC, Reel SM, Arounleut P, Esqueda LT, Fuller CE  et al.  Murine modeling of IDH-mutant 1p/19q-codeleted oligodendroglioma reveals genotype specific phenotypes.  bioRxiv  2026 May 19;. pii:2026.05.14.725183
  32. Brat DJ, Aldape K, French PJ, Louis DN, Nasrallah MP, Reifenberger G, Reuss DE, Touat M, van den Bent MJ, Wesseling P  et al.  cIMPACT-NOW update 12: Refining Pathology-based Risk Stratification and Grading for IDH-mutant Gliomas.  Neuro Oncol  2026 May 18;. pii:noag108
  33. Basakis P, Shih LK, Li J, Brat DJ  Uncovering a feedback loop in glioblastoma that reinforces stemness and immunosuppression.  J Clin Invest  2026 May 15;136(10). pii:e205841
  34. Yu X, Song X, Schäfer RA, Meng Q, Tiek D, Wu R, He Q, Walker M, Cao Q, Yang R  et al.  An EGFR co-amplified lncRNA HELDR promotes glioblastoma malignancy through KAT7-driven gene programs.  Nat Cell Biol  2026 May;28(5):972-985. doi:10.1038/s41556-026-01924-w
  35. Wu R, Yu X, Song X, He Q, Walker M, Sisbarro D, Horbinski C, Tiek D, Hu B, Zhang N  et al.  Tumor-associated astrocytes augment cholesterol synthesis to support glioblastoma growth through alternatively spliced QKI isoforms.  Neuro Oncol  2026 May 01;28(5):1163-1178. doi:10.1093/neuonc/noag030
  36. Rajan A, Castro FR, de Godoy LL, Hanaoka M, Turk S, Desiderio L, Stupp R, Mohan S, Chawla S  Imaging biomarkers for detecting IDH mutations and monitoring response to novel targeted therapies: Current insights and future perspectives.  Neuro Oncol  2026 May 01;28(5):1101-1116. doi:10.1093/neuonc/noag028
  37. Lassman AB, Polley MC, Iwamoto FM, Gondi V, Sulman EP, Wolchok JD, Mehta MP  Reply to: Blood-Brain Barrier Heterogeneity in NRG BN007: Implications for Immunotherapy Delivery.  J Clin Oncol  2026 May;44(13):1267-1268. doi:10.1200/JCO-25-02821
  38. Visa MA, Liggett MR, Lashley S, Bhatti U, Dawood ZA, Anand A, Gill NP, Scholtens DM, Wang B, Alam HB  Valproic acid for treatment of traumatic brain injury: Study protocol for the VIBRANT prospective randomized trial.  Transfusion  2026 May;66 Suppl 1(Suppl 1):S266-S277. doi:10.1111/trf.70029
  39. Benato A, Texakalidis P, Wolinsky JP  Reconstruction of posterior elements of the spine with femoral shaft allograft after spondylectomy for En bloc resection of tumor.  Eur Spine J  2026 May;35(5):2519-2530. doi:10.1007/s00586-025-09141-z
  40. Khazanchi R, Govind S, Jain R, Vignolles-Jeong J, Munjal V, Chaliparambil R, Damante M, Chandler JP, Ghalib L, Huang W  et al.  Unsupervised clustering analysis reveals distinct postoperative cortisol trajectories following pituitary adenoma resection in Cushing's disease.  J Neurooncol  2026 Apr 30;177(3). pii:132
  41. Luo M, Wu S, Huang C, Zheng Z, Xia Q, Li Y, Zhou X, Hong S, Zhong R, Li W  et al.  Inhibition of PRMT5-dependent YAP methylation attenuates tumorigenicity and radioresistance in glioblastoma.  Cancer Lett  2026 Apr 28;644:218308. doi:10.1016/j.canlet.2026.218308
  42. Jiang K, Al-Mistarehi AH, Zaitoun KJ, Weber-Levine C, Xia Y, Mendelson BZ, Ksabi NL, Papali P, Neerumalla S, Antar A  et al.  Utility of direct wave intraoperative neuromonitoring for intramedullary spinal cord tumor resection.  J Neurosurg Spine  2026 Apr 24;45(1):79-88. doi:10.3171/2025.11.SPINE25124
  43. Lee C, Mille MM, Griffin KT, Rigsby C, Popescu A, Gopalakrishnan M, Leisenring W, Peterson S, Dome JS, Laurie F  et al.  Estimation of Detailed Cardiac Doses for Pediatric Radiation Therapy Patients in National Wilms Tumor Study.  Int J Radiat Oncol Biol Phys  2026 Apr 15;. pii:S0360-3016(26)00570-5
  44. Memon R, Talati R, Song R, Ordon M, Dixit KS, Khan OH  Elevated neutrophil-to-lymphocyte ratio as a prognostic factor in primary central nervous system lymphoma.  Neurooncol Adv  2026;8(1):vdag124. pii:vdag124
  45. Kim H, Gomez A, Dixit KS  First report of a clinical and radiologic response to vorasidenib in a patient with isocitrate dehydrogenase-mutant brainstem astrocytoma.  Neurooncol Pract  2026 Apr;13(2):428-431. doi:10.1093/nop/npaf131
  46. Rodriguez A, Dixit K, O'Hara RM, Vojnic M  Efficacy of tepotinib in patients with high-grade glioma with MET alterations: A case series.  Neurooncol Pract  2026 Apr;13(2):422-427. doi:10.1093/nop/npaf130
  47. Zhao C, Lin Y, Chen H, Liu H, Hu W, Wang X, Chen J, Luo N, Qi X, Han S  et al.  S100A8-associated inflammatory microenvironment is related to its cell-of-origin and potentiates BRAF inhibitor resistance in papillary craniopharyngioma.  Clin Exp Med  2026 Apr 01;26(1). pii:210
  48. Aggarwal A, Youngblood MW, Picart T, Najem H, Oten S, Cady MA, Magill ST, Horbinski CM, Chandler JP, Heimberger AB  et al.  Meningioma cell reprogramming and microenvironment interactions underlie brain invasion.  Neuro Oncol  2026 Apr 01;28(4):926-938. doi:10.1093/neuonc/noaf292
  49. Smith HL, Duckett DJ, Mejia-Bautista M, Alshawa A, Jamshidi P, Castellani RJ, Lukas RV, Chandler JP, Jennings LJ, Santana-Santos L  et al.  IDH-wildtype astrocytoma with FH mutation, epigenetic similarity to IDH-mutant astrocytoma, and hypermethylation of CDKN2A arising in the brainstem.  J Neuropathol Exp Neurol  2026 Apr 01;85(4):398-401. doi:10.1093/jnen/nlaf086
  50. Billingham LK, DeLay SL, Eshac Y, Chia TY, Tripathi S, Olson IE, Zilinger K, Subbiah J, Wang Z, Sadagopan NS  et al.  Microglial fructose metabolism is essential for glioblastoma growth.  Proc Natl Acad Sci U S A  2026 Mar 24;123(12):e2521256123. pii:e2521256123
These are the publications from our team members that have been most recently indexed by PubMed. Visit PubMed to see more of our publications.

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