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Recent Publications

Browse recent studies from the Lou and Jean Malnati Brain Tumor Institute to learn more about our cutting-edge research.

  1. He Z, Li W, Liu T, Li X, Han J, Zhang T, Yuan Y  GAGM: Geometry-aware graph matching framework for weakly supervised gyral hinge correspondence.  Med Image Anal  2026 Jan;107(Pt A):103820. doi:10.1016/j.media.2025.103820
  2. Aggarwal A, Youngblood MW, Picart T, Najem H, Oten S, Cady MA, Magill ST, Horbinkski CM, Chandler JP, Heimberger AB  et al.  Meningioma cell reprogramming and microenvironment interactions underlie brain invasion.  Neuro Oncol  2025 Dec 31;. pii:noaf292
  3. Duckett D, Santana-Santos L, McCord M, Smith V, Lopes MBS, Youngblood MW, Magill ST, Chandler JP, Heimberger AB, Lukas R  et al.  Development, validation, and utility of a clinically applicable methylation classifier for recurrence risk prediction in meningiomas.  Acta Neuropathol Commun  2025 Dec 29;13(1):259. pii:259
  4. Goerzen D, Kim M, Schroff C, Hoang MN, Wollowitz JS, Kolb A, Walshon JP, McCortney K, Horbinski C, Galbraith K  et al.  Machine perception liquid biopsy identifies brain tumours via systemic immune and tumour microenvironment signature.  Nat Nanotechnol  2025 Dec 24;. doi:10.1038/s41565-025-02080-2
  5. Amirkhani N, Maroufi F, Pour-Rashidi A, Shirani M, Chandler JP  Impact of anti-seizure medication duration on postoperative seizures following supratentorial high-grade glioma resection: a mixed-model and tree-based approach.  J Neurooncol  2025 Dec 23;176(2):134. doi:10.1007/s11060-025-05373-7
  6. Tomita Y, Link G, Ge Y, Gold ERH, Racanelli A, Cardona HJ, Romero M, Gadd S, Watanabe J, Uchida E  et al.  Effects of combination therapy of a CDK4/6 and MEK inhibitor in diffuse midline glioma preclinical models.  PLoS One  2025;20(12):e0323235. pii:e0323235
  7. Visa MA, Liggett MR, Lashley S, Bhatti U, Dawood ZA, Anand A, Gill NP, Scholtens DM, Wang B, Alam HB  Valproic acid for treatment of traumatic brain injury: Study protocol for the VIBRANT prospective randomized trial.  Transfusion  2025 Dec 20;. doi:10.1111/trf.70029
  8. Youngblood MW, Kumari A, Kang YT, Gould A, Habashy K, Gomez M, Lingamarla H, Morey T, Chen L, Congivaram H  et al.  Dynamic release of extracellular particles after opening of the blood-brain barrier predicts glioblastoma susceptibility to paclitaxel.  Nat Commun  2025 Dec 16;16(1):11045. pii:11045
  9. Li Y, Sheng M, Li W, Liu S, Wang B, Liu B, Luo M, Zhou X, Xia Q, Hong S  et al.  Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity.  Nat Commun  2025 Dec 13;. doi:10.1038/s41467-025-67119-3
  10. Song X, Tiek D, Lu M, Yu X, Wu R, Walker M, He Q, Sisbarro D, Hu B, Cheng SY  A single-cell atlas of RNA alternative splicing in the glioma-immune ecosystem.  Genome Biol  2025 Dec 12;26(1):426. pii:426
  11. Wu M, Yang Y, Zhang J, Efimov AI, Li X, Zhang K, Wang Y, Bodkin KL, Riahi M, Gu J  et al.  Patterned wireless transcranial optogenetics generates artificial perception.  Nat Neurosci  2025 Dec 08;. doi:10.1038/s41593-025-02127-6
  12. Colman H, Lombardi G, Wong ET, Walbert T, Eoli M, Lassman AB, Peereboom DM, Kizilbash SH, Kamiya-Matsuoka C, Pitz MW  et al.  STELLAR: Phase III, Randomized, Open-Label Study of Eflornithine Plus Lomustine Versus Lomustine Alone in Patients With Recurrent Grade 3 Astrocytoma.  J Clin Oncol  2025 Dec 01;:JCO2501204. doi:10.1200/JCO-25-01204
  13. Nguyen TH, Nguyen HT, Vu V, Lam BT, Huynh P, Wang T, Li X, Bagci U, Xu M  DuetMatch: Harmonizing semi-supervised brain MRI segmentation via decoupled branch optimization.  Comput Med Imaging Graph  2025 Dec;126:102666. doi:10.1016/j.compmedimag.2025.102666
  14. Sadagopan NS, Gomez M, Tripathi S, Billingham LK, DeLay SL, Cady MA, Congivaram HTS, Chia TY, Wan H, Wang S  et al.  NOTCH3 drives fatty acid oxidation and ferroptosis resistance in aggressive meningiomas.  J Neurooncol  2025 Dec;175(3):979-991. doi:10.1007/s11060-025-05208-5
  15. Fanuzzi M, Zheng S, Horbinski CM, Shaaban MA, Congivaram H, Du R, Tripathi S, Hurley L, Kumthekar P, Ahmed A  et al.  Targeting Survivin: Now I Become Death, the Destroyer of Cells.  Int J Mol Sci  2025 Nov 26;26(23). pii:11417
  16. Sears TK, McCord M, Wang W, Steffens A, McCortney K, Chaliparambil R, Sarkaria JN, Horbinski CM  Methylation-induced suppression of YAP/TAZ confers sensitivity to HDAC inhibitors in high-grade IDH mutant gliomas.  JCI Insight  2025 Nov 24;10(22). pii:e195385
  17. Saathoff MR, Chojak R, Chen RX, Kazi HA, Faisal UH, Shireman JM, Drewes N, Park CH, Fan X, Khan SA  et al.  LMNA-PRKDC axis enhances DNA repair and promotes chemoresistance in glioblastoma.  Cell Death Dis  2025 Nov 21;. doi:10.1038/s41419-025-08226-3
  18. McHugh D, Dallos M, Teo MY, McBride SM, Gopalan A, Arfe A, Gaffney CD, Amjed M, McCann PJ, Benoliel H  et al.  Accelerating Drug Development in Hormone-Naïve Prostate Cancer Through Multi-Modal Therapy Strategies: The MetaCURE Phase 2 Randomized Clinical Trial.  Clin Cancer Res  2025 Nov 20;. doi:10.1158/1078-0432.CCR-25-2679
  19. Jin Z, Li X, Hou X, Hu J, Zhuo Y, Shi J, Xu T, Zhao Q, Jing Z  Single-atom Ca nanozyme induces glioma death through Ca2+-overload-enhanced catalytic tumor nanotherapy, ferroptosis and synergistic remodeling of the immune microenvironment.  J Nanobiotechnology  2025 Nov 13;23(1):716. pii:716
  20. Mahajan AS, Dussold C, Kim S, Jarvis R, Hurley LA, Tommasini-Ghelfi S, Park J, Forsyth CM, Zhang B, Miska J  et al.  cGAS-agonistic spherical nucleic acids reprogram the glioblastoma immune microenvironment and promote antitumor immunity.  Proc Natl Acad Sci U S A  2025 Nov 11;122(45):e2409557122. pii:e2409557122
  21. Tiek D, Song X, Wu R, Yu X, Walker M, Mao Y, Sisbarro D, He Q, Magassa A, Singh A  et al.  Cysteine addiction in drug resistant glioblastoma and therapeutic targeting with designer selenium compounds.  Neuro Oncol  2025 Nov 10;. pii:noaf265
  22. Gondi V, Pugh SL, Mehta MP, Wefel JS, Tomé WA, Sun AY, Grecula J, Redmond KJ, Fogh S, Gaspar L  et al.  Hippocampal Avoidance During Prophylactic Cranial Irradiation for Patients With Small Cell Lung Cancer: Randomized Phase II/III Trial NRG-CC003.  J Clin Oncol  2025 Nov 10;43(32):3516-3525. doi:10.1200/JCO-25-00221
  23. De La Fuente MI, Brastianos PK, Gampel B, Nassiri F, Raleigh DR, Ida CM, Abdelbaki MS, Pekmezci M, Bagley S, Young JS  et al.  Reflecting on Scientific Growth and Innovation as the Society for Neuro-Oncology Turns 30.  Neuro Oncol  2025 Nov 04;. pii:noaf255
  24. Le Rhun E, Sain D, Erridge SC, Reardon DA, Minniti G, Roth P, Wick W, Nabors B, Sampson J, Mason W  et al.  Proton Pump Inhibitor Use and Survival in Patients With Newly Diagnosed Glioblastoma.  JAMA Netw Open  2025 Nov 03;8(11):e2545578. pii:e2545578
  25. Khalili BF, Chojnacki MR, Dixit K, Gururangan K, Horbinski C, Rosenow JM, Hsieh JK, Magill ST, Tate MC, Lukas RV  et al.  Surgical Treatment of Brain Tumor-Related Epilepsy: Current and Emerging Strategies.  Cancers (Basel)  2025 Nov 01;17(21). pii:3539
  26. Hu W, Zhao C, Zheng W, Lin Y, Luo N, Liu H, Wang X, Qi X, Wang X, Li XN  et al.  Use of integrated spatial transcriptomics and histopathological analysis in adamantinomatous craniopharyngiomas to identify stromal cells as a new cellular source of leukemia inhibitory factor.  J Neurosurg  2025 Nov 01;143(5):1336-1349. doi:10.3171/2025.4.JNS243146
  27. Myneni S, Tang L, Akbari H, Mayne R, Kazemi F, Xiong R, Redmond KJ, Bilsky MH, Charest-Morin R, Tobert DG  et al.  The Spinal Chordoma Patient Reported Outcome Survey (spCPROS): a patient-centered, disease-specific tool for assessing quality of life in spinal chordoma patients.  J Neurooncol  2025 Nov;175(2):813-824. doi:10.1007/s11060-025-05181-z
  28. Corn BW, Paulus R, Gondi V, Mehta MP, Fogh S, Wefel JS, Videtic GM, Sun A, Yoon H, Heinzerling JH  et al.  "Hope" Drives Quality of Life in Patients With Brain Metastases, But, the "Hope Center" Remains Elusive: An Analysis of NRG-CC003.  Int J Radiat Oncol Biol Phys  2025 Nov 01;123(3):642-652. doi:10.1016/j.ijrobp.2025.06.3884
  29. Gruchala T, Lewis CW, Abplanalp K, Jayabalan P, Walunas TL, Johnson JL, Wainwright DA, Lukas RV, Spill G, Roy I  Predicting medical prognosis in patients with glioblastoma during inpatient rehabilitation using bed mobility function.  PM R  2025 Nov;17(11):1343-1353. doi:10.1002/pmrj.13402
  30. Kamijo Y, Mächler P, Ness N, Vu CQ, Kusakizako T, Mannuthodikayil J, Ku Z, Boisvert M, Grebenik E, Miyazaki I  et al.  A red fluorescent genetically encoded biosensor for in vivo imaging of extracellular L-lactate dynamics.  Nat Commun  2025 Oct 29;16(1):9531. pii:9531
  31. Zannikou M, Duffy JT, Procissi D, Najem H, Levine RN, Thakur A, Hambardzumyan D, Lee-Chang C, Leoni L, Horbinski CM  et al.  Bi-specific T cell-engaging antibody triggers protective immune memory and glioma microenvironment remodeling in immune-competent preclinical models.  J Immunother Cancer  2025 Oct 28;13(10). pii:e011714
  32. Cherng HR, Sun K, Bentzen SM, Brown PD, Armstrong TS, Palmer JD, Gondi V, Mehta MP, Mishra MV  Redefining Neurocognitive Outcomes After Radiation for Brain Metastases: A Patient-Level Meta-Analysis of Recovery Following Initial Decline.  J Natl Cancer Inst  2025 Oct 22;. pii:djaf264
  33. Barnes A, Gaikwad HK, Siegel D, Angarita D, Nebbia M, Anchordoquy T, Bourne D, Stewart M, Yildirim A, Fierro Cota MM  et al.  Role of Serum Stability and Lipoprotein Interactions in Lipid Structure-Tumor Accumulation Relationship.  ACS Nano  2025 Oct 21;19(41):36435-36450. doi:10.1021/acsnano.5c10594
  34. Benavides ED, Fuentes MDM, Bell L, Benedicenti L, Galban EM, Niggel JK, Murgiano L, Lenz JA, Miska JM, Amankulor NM  et al.  The role of regulatory T cells in central nervous system diseases in dogs: fighting with a double-edged sword toward translational discoveries.  Am J Transl Res  2025;17(10):8222-8242. doi:10.62347/RTGF8675
  35. Hou D, Wang S, Castro BA, Katz JL, Dapash M, Arrieta VA, Vazquez-Cervantes GI, Wan H, Billingham LK, Du R  et al.  Dual aVß8 Integrin and PD-1 Blockade Overcomes TGFβ-Mediated B-Cell Suppression to Enhance Anti-Tumor Immunity.  Neuro Oncol  2025 Oct 14;27(9):2355-2369. doi:10.1093/neuonc/noaf106
  36. Li J, Ross JL, Hambardzumyan D, Brat DJ  Immunopathology of Glioblastoma.  Annu Rev Pathol  2025 Oct 08;. doi:10.1146/annurev-pathmechdis-042524-025950
  37. Liang K, Zhou W, Li X, Wu J, Li D, Xie Y, Wei X  Quantitative analysis and trends in the study of the effects of electromagnetic radiation on the nervous system from a bibliometric perspective.  Electromagn Biol Med  2025 Oct 03;:1-14. doi:10.1080/15368378.2025.2568667
  38. Lo SS, Halasz LM, Choi S, Kumthekar P, Wang TJC, Shu HK, Sloan AE, Olson JJ  Congress of Neurological Surgeons systematic review and evidence-based guidelines for the role of radiotherapy in the management of patients with diffuse low grade glioma in adults: update.  J Neurooncol  2025 Oct;175(1):21-33. doi:10.1007/s11060-025-05074-1
  39. Xia Y, Papali P, Al-Mistarehi AH, Ahmed AK, Hansen LJ, Meyer C, Gross J, Khan M, Winkle M, Bettegowda C  et al.  Long-term functional outcomes and their relationship to nerve root sacrifice after definitive surgery for sacrococcygeal chordoma.  J Neurosurg Spine  2025 Oct 01;43(4):481-488. doi:10.3171/2025.3.SPINE241408
  40. Ali H, Zhou N, Chen L, van Hijfte L, Tulaiha R, Karri V, Zhou Y, Habashy K, Arrieta VA, Kim KS  et al.  YBX1&YBX3 as novel targets to potentiate immune checkpoint blockade response in gliomas.  Neuro Oncol  2025 Sep 30;. pii:noaf227
  41. Mehta MP, Gondi V, Ahluwalia MS, Roberge D, Sio TTW, Trifiletti DM, Muanza T, Krpan AM, Zhu Z, Ramakrishna NR  et al.  Tumor Treating Fields (TTFields) therapy after stereotactic radiosurgery for brain metastases from non-small cell lung cancer: final results of the phase 3 METIS study.  Int J Radiat Oncol Biol Phys  2025 Sep 29;. pii:S0360-3016(25)06217-0
  42. Wainwright D, Lukas R, Zhai L, Lauing K, Kim M, Koch T, Penco-Campillo M, Bommi P, Dixit K, Kumthekar P  et al.  Newly diagnosed glioblastoma IDHwt patients treated with radiation, nivolumab, and BMS-986205.  Res Sq  2025 Sep 25;. pii:rs.3.rs-7567487
  43. Pour-Rashidi A, Zandpazandi S, Perronne L, Hill VB, Krumpelman C, Subedi K, Kelahan L, Borhani AA, Savas H, Avery R  et al.  Intracranial Metastases from Uterine Leiomyosarcoma: A Systematic Review and Case Illustration.  J Clin Med  2025 Sep 20;14(18). pii:6631
  44. Lassman AB, Polley MC, Iwamoto FM, Sloan AE, Wang TJC, Aldape KD, Wefel JS, Gondi V, Gutierrez AN, Manasawala MH  et al.  Dual Immune Check Point Blockade in MGMT-Unmethylated Newly Diagnosed Glioblastoma: NRG Oncology BN007, a Randomized Phase II/III Clinical Trial.  J Clin Oncol  2025 Sep 20;43(27):3032-3040. doi:10.1200/JCO-25-00618
  45. Khan F, Petrosyan E, Liu Y, Bahrami A, Taefi E, Geula C, Lesniak MS, Chen P  Microglial TBK1 Signaling Promotes Breast Cancer Brain Metastasis.  Cancer Res  2025 Sep 18;. doi:10.1158/0008-5472.CAN-25-1791
  46. Khalili BF, Dixit K, Kamson DO, Horbinski C, Przybyla DJ, Tate MC, Heimberger AB, Lukas RV, Templer JW  The excitatory milieu in glioma: Mechanisms and therapeutic avenues.  Neuro Oncol  2025 Sep 17;27(8):1932-1945. doi:10.1093/neuonc/noaf063
  47. Yu X, Song X, Tiek D, Wu R, Walker M, Horbinski C, Hu B, Cheng SY  Targeting PDGFRA-SHP2 signaling enhances radiotherapy in IDH1-mutant glioma.  Neuro Oncol  2025 Sep 17;27(8):2023-2034. doi:10.1093/neuonc/noaf086
  48. Weber-Levine C, Xia Y, Al-Mistarehi AH, Jiang K, Mendelson BZ, Antar A, Ksabi NL, Zaitoun KJ, Papali P, Neerumalla S  et al.  The Impact of Expansile Duraplasty After Resection of Intramedullary Astrocytomas.  Oper Neurosurg  2025 Sep 16;. doi:10.1227/ons.0000000000001762
  49. Núñez FJ, Banerjee K, Mujeeb AA, Mauser A, Tronrud CE, Zhu Z, Raghuram S, Sheth MR, Agudelo JAP, Zelaya J  et al.  Autophagy Upregulation in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma Uncovers a Novel Therapeutic Target.  Res Sq  2025 Sep 11;. pii:rs.3.rs-7483444
  50. Kotecha R, Akdemir EY, Kutuk T, Ilgın C, Ahluwalia MS, Bi WL, Blakeley J, Dixit KS, Dunn IF, Galanis E  et al.  Benchmarking the efficacy of salvage systemic therapies for recurrent meningioma: A RANO group systematic review and meta-analysis to guide clinical trial design.  Neuro Oncol  2025 Sep 08;27(7):1670-1685. doi:10.1093/neuonc/noaf009
These are the publications from our team members that have been most recently indexed by PubMed. Visit PubMed to see more of our publications.

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