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NUSeq (genomic services)

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Mission

The NUSeq Core Facility provides state-of-the-art genomics instrumentation, bioinformatics, and technological expertise to support genome and biomedical research at the Feinberg School of Medicine and Northwestern University. Major technologies provided include next-generation sequencing, microarray, high-throughput DNA extraction, cell line authentication, quantitative and digital PCR, Sanger sequencing (via a partnership), gene expression profiling, genotyping, epigenomics, DNA-protein interaction, 3D genome and DNA accessibility, and metagenomics. On the bioinformatics front, the Core provides data analysis and data mining services for genomics data generated in-house or externally. 

As the only genomics research facility at Northwestern, NUSeq currently provides over 80 genomics services to all groups at Northwestern on both the Evanston and Chicago campuses, as well as to Northwestern affiliates and external institutions. The Core’s highly trained lab and bioinformatics staff supports each project at every step, from experimental design to advanced data mining. Initial project consultation is provided free of charge.

Services Offered

  • Next Generation Sequencing on the Illumina Platform (NovaSeq 6000, HiSeq 4000, NextSeq, and MiSeq)
    • RNA-Seq (Including bulk RNA-seq from standard to ultra low RNA input, small RNA-seq, and single-cell RNA-seq)
    • DNA-Seq (Including whole genome, exome, and gene panel sequencing)
    • DNA Methyl-Seq
    • ChIP-Seq
    • ATAC-Seq (Including bulk and single-cell analysis)
    • Mitochondrial DNA sequencing
    • Microbiome sequencing
    • Pan-Cancer Gene Panel (New from Sept ’21)
    • VeriSeq Aneuploidy Testing (New from Sept ’21)
  • Next Generation Sequencing on the Oxford Nanopore Platform (Long Reads Sequencing)
    • Full-length RNA transcript sequencing
    • Genomic DNA structural variant and copy number variant detection
    • DNA/RNA epigenomic changes (direct detection w/o derivatization)
  • Microarray
    • Illumina BeadChip (Genotyping and DNA Methylation Analyses)
  • Bioinformatics and Data Mining
    • Experimental Design
    • NGS Data Analysis
    • Microarray Data Analysis
    • Advanced or Customized Data Mining
  • Human Cell Line Authentication
  • High-Throughput DNA Extraction
  • DNA/RNA Concentration Measurement and QC
  • Traditional Sanger Sequencing
  • Real-time Quantitative PCR (Equipment Use)
  • Digital Droplet PCR (Equipment Use)
  • NanoString nCounter (Targeted gene analysis at pathway level)

 

Contact

Xinkun 'Sequen' Wang
Director
(312) 503-3331 

Matthew Schipma, PhD
Associate Director
(312) 503-5324

Location

300 E. Superior Street
Tarry 2-770
Chicago, IL 60611

Acknowledgement

All manuscripts and grants presenting work supported by this core should include the following acknowledgement:

“This work was supported by the Northwestern University NUSeq Core Facility.”