Clinical Trials
Clinical research under the direction of the Department of Physical Medicine & Rehabilitation is conducted through Northwestern University Feinberg School of Medicine. Scientists at the medical school are conducting hundreds of clinical trials daily. Learn more about all our work via the Feinberg Office of Research Clinical Trials page.
Search below by disease or condition to explore our current clinical trials and find investigator and contact information. For more information about the research or participation, please call our office at 312-695-6829.
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Neuromodulation and Neurorehabilitation for Treatment of Functional Deficits after mTBI plus PTSDThe purpose of this study is to alleviate persisting attention deficits related to mTBI and PTSD by treating the neurocognitive system of attention. Eligibility Criteria
Location(s)
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Project 1, Adaptations of the brain in chronic pain with opioid exposureIn this project, we will study brain reorganization and behavioral responses in chronic pain with opioid exposure. Chronic back pain (CBP) is the most prevalent chronic pain condition in the US. Opiates are commonly prescribed to treat CBP; as such, these patients are a primary contributor to the opioid epidemic. … In this project, we will study brain reorganization and behavioral responses in chronic pain with opioid exposure. Chronic back pain (CBP) is the most prevalent chronic pain condition in the US. Opiates are commonly prescribed to treat CBP; as such, these patients are a primary contributor to the opioid epidemic. Although millions of people with CBP regularly use opioids, little is known about the impact of long-term opioid use on the chronic pain brain. Through pain tracking, MRI scans, and various other methods, this study will look at understanding the effect of long-term opioid use on the chronic pain brain. Eligibility CriteriaMust have a history of low back pain for a minimum of 6 months with or without signs and symptoms of radiculopathy Male or female, age 18 years or older Must be in generally stable health Must have a smartphone that will allow downloading of the pain app Must be on regular opioid or NSAID therapy for at least 3 months Location(s)
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Wearable sensors and video recording for children (birth to 24 months) to monitor motor developmentThe purpose of this study is to test flexible body-worn sensors and video technology to provide high-resolution measures of motor development in infants, starting from a very young age and continuing up to 2 years of age. This study will enroll up to 200 infants: 100 infants expected … The purpose of this study is to test flexible body-worn sensors and video technology to provide high-resolution measures of motor development in infants, starting from a very young age and continuing up to 2 years of age. This study will enroll up to 200 infants: 100 infants expected to have typical motor development and 100 infants at risk of atypical motor development (based on clinician diagnosis or risk factors such as prematurity, neonatal hypoxic ischemic encephalopathy, neonatal stroke, etc.). During each study visit, sensors will be placed on the legs, arms, chest, and head using soft bandage wraps or a gentle adhesive. The sensors will record the child’s movements in various postures and tasks. Their movements will also be recorded on video. These measurements will be completed at the approximate ages of 1-2 weeks, 1 months, 3 months, 6 months, 9 months, 1 year, and 2 years old. Each study visit will take about 1-2 hours. Compensation will be provided. If ever it’s too difficult to travel to one of these locations, another option is that we can come to you, and do a study visit at your home. Eligibility CriteriaInfant must meet the following criteria:
Location(s)
IRB number STU00207900 Copy Study URL to Clipboard Copy |
Brain pathophysiology of osteoarthritis painThis research study is being done to better understand the causes of knee pain in people with osteoarthritis, and to identify factors that lead to persistent pain after total knee replacement or recovery of knee pain following a total knee replacement. We are also trying to better understand the changes … This research study is being done to better understand the causes of knee pain in people with osteoarthritis, and to identify factors that lead to persistent pain after total knee replacement or recovery of knee pain following a total knee replacement. We are also trying to better understand the changes in brain function, senses, personality and performance abilities after a total knee replacement surgery. Participants will be enrolled in the study for about 13 months and will undergo up to 3 MRI scans of their brain. Eligibility CriteriaMust have a history of osteoarthritis in a knee and have elected to undergo total knee replacement surgery (TKR) in the knee. Or may have a history of osteoarthritis in a knee and have not elected to undergo a TKR. Must be 40 years or older and be in generally stable health. Must have a smartphone that will allow downloading of a pain app. If female, must be post-menopausal for at least one year or practicing an accepted, highly effective method of contraception or abstinence and plan to continue during the course of the study. Location(s)
IRB number STU00207973 Copy Study URL to Clipboard Copy |
Project 1, Adaptations of the Brain in Chronic Pain with Opioid ExposureIn this project, we will study brain reorganization and behavioral responses in chronic pain with opioid exposure. Chronic back pain (CBP) is the most prevalent chronic pain condition in the US. Opiates are commonly prescribed to treat CBP; as such, these patients are a primary contributor to the opioid epidemic. … In this project, we will study brain reorganization and behavioral responses in chronic pain with opioid exposure. Chronic back pain (CBP) is the most prevalent chronic pain condition in the US. Opiates are commonly prescribed to treat CBP; as such, these patients are a primary contributor to the opioid epidemic. Although millions of people with CBP regularly use opioids, little is known about the impact of long-term opioid use on the chronic pain brain. Through pain tracking, MRI scans, and various other methods, this study will look at understanding the effect of long-term opioid use on the chronic pain brain. Eligibility Criteria Must have a history of chronic pain for a minimum of 6 months with or without signs and symptoms of radiculopathy. Male or female, age 18 years or older. Must be in generally stable health. Must have a smartphone that will allow access to a pain diary website. Must be on regular opioid therapy for at least 3 months. Location(s)
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XIRB A randomized, two-arm, placebo-controlled, participant and investigator-blinded study investigating the efficacy, safety and tolerability of DFV890 in patients with symptomatic knee osteoarthritisThe purpose of this study is to learn more about the efficacy and safety of DFV890 and how it works in participants with knee osteoarthritisParticipants will be in the study for about 19 weeks with a 12 week treatment period where participants will get one of two study treatments: placebo …
Eligibility Criteria
Location(s)
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