NUDACC Collaborations

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Current Collaborations

Learn more about past successful collaborations of the members of Northwestern University Data Analysis and Coordinating Center (NUDACC). To work with NUDACC, contact our team at

 Glycemic Observation and Metabolic Outcomes in Mothers and Offspring (GO MOMs)

This multicenter observational study is designed to characterize the glycemic profile of pregnancy to understand potential early indicators of dysglycemia during pregnancy and long-term sequelae. Continuous glucose monitoring technology will be central for data collection. NUDACC is the Biostatistics Research Center for this new, NIDDK-supported consortium, serving as a central leadership hub for all project coordination and data related components of the study. See the GO MOMs website for more information (

 GO MOMs Ancillary Studies

  • The goal of the ancillary study Glycemic Observation Using A1C for Gestational Diabetes Diagnosis (GO A1C GDM) is to improve hemoglobin A1C (A1C)’s ability to detect hyperglycemia in pregnancy and predict associated complications by adjusting for gestational changes in red blood cell (RBC) kinetics. GO A1C GDM will use ongoing multicenter GO MOMs study measurements from continuous glucose monitoring (CGM), hemoglobin A1C, and complete blood counts (CBCs), while adding additional hematologic measurements (single cell hemoglobin and volume measurements from CBCs, reticulocyte counts, and ferritin) at each time point to make these personalized RBC adjustments. To achieve this, GO A1C GDM will use mechanistic modeling of GO MOMs data to improve A1C-based glycemia estimation for the purpose of predicting hyperglycemia-associated adverse pregnancy outcomes.
  • The GO MOMs Nutrition Study is an observational substudy nested within the GO MOMs parent study. Participants will complete 6 dietary recalls via the Automated Self-Administered 24-hour (ASA24) Dietary Assessment Tool during their pregnancies. The goal is to evaluate associations between dietary carbohydrate content at <22 weeks’ gestation and maternal glycemia 24-28 weeks’ gestation and neonatal birthweight.

 High Intensity Walking (HIW) Trial

This ongoing NIH/NIA-funded clinical trial is designed to investigate HIW in frail, older adults and involves 10 study sites.


The ongoing QUARTET USA trial is a randomized clinical trial designed to investigate treatment of hypertension in the Federally Qualified Health Center (FQHC) Access Community Health Network in Chicago, Illinois.

 Dementia Risk Prediction Project (DRPP)

The Dementia Risk Prediction Project (DRPP) is a new consortium of 11 cohorts spanning multiple sites across the US and Europe. Our collaborative team is working to harmonize the data and will build a cloud-based computing platform. To find out more, go to the DRPP website

 Healthy Hearts for Michigan (HH4M)

The Healthy Hearts for Michigan project aims to intervene in primary care clinics in Michigan via practice facilitation to help promote overall cardiovascular health for their patients; areas of focus are blood pressure control for patients with hypertension and smoking cessation for patients who are currently smoking.

 Liver Cirrhosis Network (LCN)

The Liver Cirrhosis Network (LCN) involves two studies across 10 centers in the United States: a prospective observational cohort to study factors contributing to diseases progression, and a double-blind randomized controlled trial to evaluate efficacy of statin therapy in delaying disease progression in patients with cirrhosis. See the LCN website for more information (

 Northwestern Embedded Emergency Department Physical Therapy Protocol for Acute Low Back Pain (NEED-PT)

Northwestern Embedded Emergency Department Physical Therapy Protocol for Acute Low Back Pain (NEED-PT) is a single center physician-randomized trial comparing a physical therapy intervention (pairing a physical therapist with an Emergency Department physician) vs. usual care in patients reporting to the Emergency Department with low back pain.

 SuperAging Project

The SuperAging Study unites a network of sites across the US and Canada dedicated to identifying the biologic, genetic and psychosocial factors associated with SuperAging. SuperAgers are 80+ year-olds with episodic memory performance that is at least as good as what would be considered normal for 50-60 year-olds. NUDACC is partnering with the SuperAging group for data capture, quality assessment and statistical analyses of cutting edge genetics, imaging and sensor data. Learn more about SuperAging here.

 VIVID Study

The VIVID Study (Volumetric Lumpectomy Specimen Image Visualization for Intraoperatively Directing Cavity Shaves) is a Phase II Study designed to evaluate preliminary efficacy of a novel imaging device to reduce the positive margin rate after surgical resection of breast cancers.


The overarching goal of the HeartShare program is to characterize mechanisms of disease and identify therapeutic targets in patients with heart failure with preserved ejection fraction via large-scale analyses of phenotypic data, images, and omics. See the HeartShare website for more information (

 Hyperbaric Oxygen Therapy for Ulcerative Colitis (HBOT-UC)

This multicenter clinical trial is designed to confirm the treatment benefits of hyperbaric oxygen therapy for ulcerative colitis. The study will enroll participants with ulcerative colitis, hospitalized for an acute moderate to severe flare, from 19 clinical sites across the Unites States. NUDACC is the Data Coordinating Center for this new, NIDDK-funded clinical trial.

Past Collaborations

 HAPO Follow-Up Study

The observational Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Follow-Up Study was designed to investigate associations of maternal glycemia during pregnancy with maternal glucose metabolism and child adiposity 11-14 years after delivery. HAPO Follow-Up involved oral glucose tolerance tests and physical exams in over 4800 mother-offspring pairs at 10 international study sites. Primary findings were reported in JAMA (2018), followed by multiple other publications pertaining to secondary outcomes:

 Diagnostic Analyzer for Selective Hybridization (DASH) Study

The DASH Study was part of the Rapid Acceleration of Diagnostics (RADx) initiative sponsored by the NIH, and was designed to evaluate the validity and accuracy of a point-of-care PCR test for the diagnosis of SARS-CoV-2 infection in symptomatic and asymptomatic individuals. To learn more about DASH, click here.