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Northwestern University Feinberg School of Medicine
Driskill Graduate Program in Life Sciences

Recent Student Publications

Listed here is a selection of recent publications by current students.

  1. Sebo ZL, Chakrabarty RP, Grant RA, D'Alessandro KB, Koss AR, Blum JLE, Davidson SM, Reczek CR, Chandel NS  Metformin inhibits mitochondrial complex I in intestinal epithelium to promote glycaemic control.  Nat Metab  2026 May 08;. doi:10.1038/s42255-026-01530-y
  2. Matias EG, Austin DE, Franca KC, Maguire C, Lockhart JS, Lantz CW, Tambur AR  Not all Mismatches Were Created Equal: Empirical Identification of Regions Within HLA-DQ Molecules That Harbor the Highest Immunogenicity.  Transplantation  2026 May 01;110(5):e1040-e1049. doi:10.1097/TP.0000000000005609
  3. Lockhart JS, Lantz CW, Tambur AR  Blind Spots in HLA Class II Detection Generate Challenges for Antibody and RNA-based Assays.  Transplantation  2026 May 01;110(5):e952-e955. doi:10.1097/TP.0000000000005592
  4. Brown AK, Niu H, Shen J, Zhang Y, Vaz de Castro PAS, Kasmani MY, Lin S, Topchyan P, Mani NL, Volberding PJ  et al.  PIM1 kinase-regulated cellular metabolism sustains differentiation and function of effector CD8+ T cells during chronic viral infection.  J Immunol  2026 Apr 15;215(4). pii:vkag062
  5. Kubo H, Lu L, VanZanten M, Thyagraj J, Saunders DC, Gao R, Laronda MM  Ligand-based directed differentiation to produce granulosa-like cells expressing steroidogenic enzyme genes.  Stem Cell Res  2026 Apr 01;94:103978. doi:10.1016/j.scr.2026.103978
  6. Meghani K, Yu Y, Frydenlund N, Li EZ, Choy B, Abdulkadir SA, Meeks JJ  Genomic and Transcriptomic Profiling of High-risk Bladder Cancer Reveals Diverse Molecular and Microenvironment Ecosystems.  Eur Urol  2026 Apr;89(4):346-352. doi:10.1016/j.eururo.2025.09.4138
  7. Brea L, Shi H, Keo V, Huang J, Peng L, Chu Q, Xie W, Xie Y, Senthil S, Breneman MT  et al.  FOXA1 loss drives basal/squamous de-differentiation of prostate cancer and induces an immunosuppressive tumor microenvironment.  Nat Commun  2026 Mar 28;. doi:10.1038/s41467-026-71121-8
  8. Billingham LK, DeLay SL, Eshac Y, Chia TY, Tripathi S, Olson IE, Zilinger K, Subbiah J, Wang Z, Sadagopan NS  et al.  Microglial fructose metabolism is essential for glioblastoma growth.  Proc Natl Acad Sci U S A  2026 Mar 24;123(12):e2521256123. pii:e2521256123
  9. Hepler C, Waldeck NJ, Weidemann BJ, Marcheva B, Chen YJ, Hecker J, Zhu Z, Nozawa R, Mastroni JV, Thorne AK  et al.  Adipocyte NADH dehydrogenase reverses circadian and diet-induced metabolic syndrome.  Nat Metab  2026 Mar;8(3):559-571. doi:10.1038/s42255-026-01464-5
  10. Bodner J, Vadlamani P, Lee AS, Helmin KA, Liu Q, Pratasenia AE, Horst MMA, Ravisankar S, Khurana S, Mendillo ML  et al.  Human CRAMP1 specifically promotes the expression of histone H1 genes.  EMBO Rep  2026 Mar;27(5):1122-1145. doi:10.1038/s44319-026-00704-9
  11. Tam SB, Waldeck NJ, Wright M, Mojsilovic-Petrovic J, Baker EM, Kiskinis E, Bass J, Kalb RG  A role for the cholinergic neuron circadian clock in RNA metabolism and mediating neurodegeneration.  Life Sci Alliance  2026 Mar;9(3). pii:e202503508
  12. Shah S, Ananthakrishnan A, DeBerge M, Glinton K, Jones RTL, Filipp M, Shen I, Lockhart J, Lantz CW, Thorp EB  Suppression of cardiac allograft vasculopathy by a macrophage efferocytosis receptor.  Am J Transplant  2026 Mar;26(3):455-466. doi:10.1016/j.ajt.2025.08.026
  13. Lee J, Berkelhammer M, O'Brien J, McNicol G, Vincent AES, Grover M, Packman AI, Kaludi B, Cho A, Gonzalez-Meler M  Imputation of urban environmental sensor data using gated attention bidirectional long short-term memory (GA-BiLSTM): methods, performance, and implications.  Environ Monit Assess  2026 Feb 27;198(3). pii:262
  14. Wang MM, Truica MI, Gattis BS, Oktawiec J, Sagar V, Basu AA, Bertin PA, Zhang X, Abdulkadir SA, Gianneschi NC  Heterobifunctional proteomimetic polymers for targeted degradation of MYC and KRAS.  Nat Commun  2026 Feb 24;17(1). pii:1706
  15. Xie W, Chu Q, Brea L, Zeng G, Wang Y, Lu X, Zheng M, Ley CR, Lei Z, Shi H  et al.  EZH2 PROTACs outperform catalytic inhibitors in prostate cancer by targeting a methylation-independent function of PRC2.  Oncogene  2026 Feb;45(5):636-649. doi:10.1038/s41388-025-03662-z
  16. Hayashi V, Seidman MA, Muller WA  Prostaglandin E2 Signaling Triggers CD31-Independent Transendothelial Migration in Vitro and in Vivo.  Am J Pathol  2026 Feb;196(2):618-632. doi:10.1016/j.ajpath.2025.09.012
  17. Jones G, Murphy A, Lee-Chang C  B cell immunity and therapeutic opportunities in brain metastases.  Front Immunol  2025;16:1740386. pii:1740386
  18. Liu K, Iyer R, Li Y, Zhu J, Cai Z, Wei J, Cheng Y, Tang AY, Wang H, Gao Q  et al.  USP22 drives tumor immune evasion and checkpoint blockade resistance through EZH2-mediated epigenetic silencing of MHC-I.  J Clin Invest  2026 Jan 02;136(1). pii:e193162
  19. Pereira A, Alvarez-Argote S, Meite I, Inui H, Sterling JK, Thorp EJ, Feinstein MJ, Filipp M, Thorp EB  Metabolic Stress and Immune Activation in Heart Failure With a Preserved Ejection Fraction.  Immunol Rev  2026 Jan;337(1):e70103. doi:10.1111/imr.70103
  20. Dipali SS, Converse A, Gowett MQ, Kamat P, Zaniker EJ, Fennell A, Chou T, Pritchard MT, Zelinski M, Phillip JM  et al.  Self-Organizing Ovarian Somatic Organoids Preserve Cellular Heterogeneity and Reveal Cellular Contributions to Ovarian Aging.  Aging Cell  2026 Jan;25(1):e70333. pii:e70333
  21. Kearney AO, Yang JY, Liu E, Wright M, Chen M, Kong J, Barish G, Thorp EB, Lin J  APOL1 G1 and G2 risk alleles modulate severity of diet-induced obesity in a transgenic mouse model.  bioRxiv  2025 Dec 25;. pii:2025.12.23.696293
  22. Fan Q, Quan J, Smith GA, Longnecker R  Zyxin restricts viral fusion and entry across multiple virus families.  J Virol  2025 Dec 23;99(12):e0165925. pii:e01659-25
  23. Beauchamp EM, Jain A, Clutter M, Nahotko D, Lopez Fajardo E, Vagadia PP, Dunne SF, Mina A, Fischietti M, Oku CV  et al.  Development of a SIN1 targeting inhibitor as a novel therapeutic approach for the treatment of malignancies.  Mol Cancer Ther  2025 Dec 22;. doi:10.1158/1535-7163.MCT-25-0298
  24. Fu X, Epting CL, Sinha A, Mongé MC, Zhao M, Glinton KE, Krishnan ST, Nguyen MLT, Dudley VJ, Waypa GB  et al.  LncRNA H19 Upregulation Links Hypoplastic Left Heart Syndrome to Impaired PINK1/Parkin-Mediated Mitophagy and Ischemic Vulnerability.  bioRxiv  2025 Dec 19;. pii:2025.12.16.694773
  25. Srivastava S, Samaniego-Castruita D, Srivastava S, Khurana S, Rehman J, Shukla V, Ben-Sahra I, Foltz DR  Rate-limiting enzymes in nucleotide metabolism synchronize nucleotide biosynthesis and chromatin formation.  Mol Cell  2025 Dec 18;85(24):4510-4525.e8. doi:10.1016/j.molcel.2025.11.009
  26. Taylor ME, Jaishankar D, Madavaraju K, Yuk SA, Zhang K, Mei H, Lantz CW, Andrade da Silva LH, Lee YM, Burke JA  et al.  Linking autophagy to endothelial cell immunogenicity in transplant-associated ischemia-reperfusion injury.  Transpl Immunol  2025 Dec;93:102315. doi:10.1016/j.trim.2025.102315
  27. Yalcin K, Alanya H, Gultekin B, Samper Figuera D, Barak T, Miyagishima DF, Youngblood MW, Hjerthen MG, Brooks A, Samuel Lopez N  et al.  Subgroup of meningiomas involving FOS and FOSB gene fusions.  Nat Commun  2025 Nov 26;16(1):10532. pii:10532
  28. Mahajan AS, Dussold C, Kim S, Jarvis R, Hurley LA, Tommasini-Ghelfi S, Park J, Forsyth CM, Zhang B, Miska J  et al.  cGAS-agonistic spherical nucleic acids reprogram the glioblastoma immune microenvironment and promote antitumor immunity.  Proc Natl Acad Sci U S A  2025 Nov 11;122(45):e2409557122. pii:e2409557122
  29. Rosas-Lemus M, Athe S, Minasov G, Pattie JA, Brunzelle JS, Chau I, Li F, Vedadi M, Ma H, Ramanathan A  et al.  S-adenosylhomocysteine analogs selectively suppress pan-coronavirus replication by inhibition of nsp14 methyltransferase.  ACS Med Chem Lett  2025 Nov 05;17(2):331-40. doi:10.1021/acsmedchemlett.5c00510
  30. Wang H, Schwirtlich T, Houskamp E, Hutch M, Murphy J, Nascimento JSPD, Zini A, Brancaleoni L, Giacomozzi S, Luo Y  et al.  Automated Detection of the Black Hole Sign for Patients with Intracerebral Hemorrhage Using Self-Supervised Learning.  AJNR Am J Neuroradiol  2025 Nov 03;46(11):2300-2309. doi:10.3174/ajnr.A8826
  31. Spurgin S, Nguimtsop AM, Chaudhry FN, Michki SN, Salvador J, Iruela-Arispe ML, Zepp JA, Mukhopadhyay S, Cleaver O  Dynamics of primary cilia in endothelial and mesenchymal cells throughout mouse lung development.  Dev Dyn  2025 Nov;254(11):1187-1202. doi:10.1002/dvdy.70008
  32. Hepler C, Waldeck NJ, Weidemann BJ, Marcheva B, Chen YJ, Hecker J, Zhu Z, Nozawa R, Mastroni JV, Thorne AK  et al.  NADH dehydrogenase reverses dietary and clock metabolic syndrome.  bioRxiv  2025 Oct 23;. pii:2025.10.22.684030
  33. Hou D, Wang S, Castro BA, Katz JL, Dapash M, Arrieta VA, Vazquez-Cervantes GI, Wan H, Billingham LK, Du R  et al.  Dual aVß8 Integrin and PD-1 Blockade Overcomes TGFβ-Mediated B-Cell Suppression to Enhance Anti-Tumor Immunity.  Neuro Oncol  2025 Oct 14;27(9):2355-2369. doi:10.1093/neuonc/noaf106
  34. Sebo ZL, Chakrabarty RP, Grant RA, D'Alessandro KB, Koss AR, Blum JLE, Davidson SM, Reczek CR, Chandel NS  Metformin inhibits mitochondrial complex I in intestinal epithelium to promote glycemic control.  bioRxiv  2025 Oct 02;. pii:2025.10.02.678294
  35. Maekawa H, Zhou Y, Aoi Y, Fain ME, Kaminski DS, Kong H, Sebo ZL, Chakrabarty RP, Howard BC, Andersen G  et al.  SGLT2 inhibition protects kidney function by SAM-dependent epigenetic repression of inflammatory genes under metabolic stress.  J Clin Invest  2025 Oct 01;135(19). pii:e188933
  36. Duval AJ, Seker-Polat F, Rogozinska M, Kinali M, Walts AE, Neyisci O, Zhang Y, Li Z, Tanner EJ, Grubbs AE  et al.  SOX9 drives a stem-like transcriptional state and platinum resistance in high-grade serous ovarian cancer.  J Clin Invest  2025 Oct 01;135(19). pii:e186467
  37. Foo CZ, Duggan A, Bartom ET, Tao L, García-Añoveros J  Differential Chromatin Accessibility, Gene Expression, and mRNA Splicing Between Developing Cochlear Inner and Outer Hair Cells.  J Assoc Res Otolaryngol  2025 Oct;26(5):531-551. doi:10.1007/s10162-025-01005-z
  38. Patil S, Lantz C, Marinovic A, Sarkar R, Lee BR, DeBerge M  Microglial metabolic reprogramming drives cognitive decline in heart failure with preserved ejection fraction.  bioRxiv  2025 Sep 16;. pii:2025.09.10.675257
  39. Schroth SL, Zhang L, Jones RT, Glinton K, Mani NL, Inui H, Davidson JT, Weinberg SE, Chandel NS, Alegre ML  et al.  Treg activation during allograft tolerance induction requires mitochondrion-induced TGF-β1 in type 1 conventional dendritic cells.  J Clin Invest  2025 Sep 16;135(18). pii:e178960
  40. Hodge N, Tétreault MP  Epithelial Ikkβ deletion modulates immune responses and the IFNγ/CXCL9 axis during early esophageal carcinogenesis.  Carcinogenesis  2025 Sep 04;46(3). pii:bgaf055
  41. Singla A, Chen K, Robelly B, Rebello C, Lantz C, Zhao L, Sinha R, Park S, Kleiboeker S, Friedewald JJ  et al.  Using Torque Teno Virus as a Serial Monitoring Tool for the Net State of Immunosuppression of Kidney Transplant Recipients.  Clin Transplant  2025 Sep;39(9):e70321. doi:10.1111/ctr.70321
  42. Groff KJ, Patel RV, Feng Y, Ghosh HS, Millares Chavez MA, O'Brien J, Chen WC, Nitturi V, Save AV, Youngblood MW  et al.  The effect of TERT promoter mutation on predicting meningioma outcomes: a multi-institutional cohort analysis.  Lancet Oncol  2025 Sep;26(9):1178-1190. doi:10.1016/S1470-2045(25)00422-X
  43. Romay MC, Ma F, Mompeón A, Silvestro M, Hernandez GE, Salvador J, Wang AL, Vandestienne M, Bardin N, Blot-Chabaud M  et al.  Region-specific gene expression and sex inform about disease susceptibility in the aorta.  Nat Cardiovasc Res  2025 Sep;4(9):1152-1171. doi:10.1038/s44161-025-00692-4
  44. Landazuri P, Cheng JJ, Leuthardt E, Kim AH, Southwell DG, Fecci PE, Neimat J, Sun D, Lega B, Panov F  et al.  Interstitial Thermal Therapy in Mesial Temporal Lobe Epilepsy.  JAMA Neurol  2025 Sep 01;82(9):915-924. doi:10.1001/jamaneurol.2025.1897
  45. Brea L, Yu J  Tumor-intrinsic regulators of the immune-cold microenvironment of prostate cancer.  Trends Endocrinol Metab  2025 Sep;36(9):855-866. doi:10.1016/j.tem.2024.12.003
  46. Southern RM, Schmitz RL, Samaniego-Castruita D, Balsells D, Han I, Ramesh P, Tran MT, Montes C, Cheong TC, Chiarle R  et al.  IgM and IgG1 B cell receptors differentially affect B cell fates and dictate the pathogenesis of mature B cell lymphomas.  Sci Adv  2025 Aug 29;11(35):eadp9391. pii:eadp9391
  47. Cobe BL, Ozer EA, Nozick SH, Hauser AR, Cianciotto NP  Draft genome sequences of Stenotrophomonas maltophilia strains UPSm1, UPSm3, and UPSm5 and Stenotrophomonas pavanii strain UPSm2.  Microbiol Resour Announc  2025 Aug 14;14(8):e0031325. pii:e00313-25
  48. Lu X, Keo V, Cheng I, Xie W, Gritsina G, Wang J, Lu L, Shiau CK, He Y, Jin Q  et al.  NKX2-1 drives neuroendocrine transdifferentiation of prostate cancer via epigenetic and 3D chromatin remodeling.  Nat Genet  2025 Aug;57(8):1966-1980. doi:10.1038/s41588-025-02265-4
  49. Xing D, Bai T, Neyisci O, Paylakhi SZ, Duval AJ, Tekin Y, Adli M  Systematic comparison and base-editing-mediated directed protein evolution and functional screening yield superior auxin-inducible degron technology.  Nat Commun  2025 Jul 18;16(1):6631. pii:6631
  50. Yang W, Guo Q, Quan S, Chalmers ZR, Parker JB, Truica M, Dufficy MF, Kerber MM, Vasan K, Gupta DG  et al.  Impaired mitochondrial metabolism is a critical cancer vulnerability for MYC inhibitors.  Sci Adv  2025 Jul 18;11(29):eadw5228. pii:eadw5228

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