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Recent Publications

Browse recent studies from the Lou and Jean Malnati Brain Tumor Institute to learn more about our cutting-edge research.

  1. Pieters TA, Hersh AM, Elsamadicy AA, Pennington Z, Santangelo G, Najjar S, Hung B, Ber R, Atallah C, Efron J  et al.  Outcomes after en bloc resection with sacrectomy of advanced colorectal carcinomas that invade the sacrum: a multiinstitutional descriptive series.  J Neurosurg Spine  2025 Mar 07;:1-7. doi:10.3171/2024.10.SPINE24391
  2. McCord M, Sears T, Wang W, Chaliparambil R, An S, Sarkaria J, James CD, Ruggeri B, Gueble S, Bindra R  et al.  The novel DNA cross-linking agent KL-50 is active against patient-derived models of new and recurrent post-temozolomide mismatch repair-deficient glioblastoma.  Neuro Oncol  2025 Mar 07;27(3):644-651. doi:10.1093/neuonc/noae257
  3. Feng H, Hu B, Vuori K, Sarkaria JN, Furnari FB, Cavenee WK, Cheng S-  Correction: EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180.  Oncogene  2025 Mar;44(10):710-711. doi:10.1038/s41388-025-03290-7
  4. Wu Y, Gao X, Liu Z, Wang P, Wu Z, Li Y, Zhang T, Liu T, Liu T, Li X  Decoding cortical folding patterns in marmosets using machine learning and large language model.  Neuroimage  2025 Mar;308:121031. doi:10.1016/j.neuroimage.2025.121031
  5. Pedder JH, Sonabend AM, Cearns MD, Michael BD, Zakaria R, Heimberger AB, Jenkinson MD, Dickens D  Crossing the blood-brain barrier: emerging therapeutic strategies for neurological disease.  Lancet Neurol  2025 Mar;24(3):246-260. doi:10.1016/S1474-4422(24)00476-9
  6. Geller JI, Renfro LA, Grundy PE, Perlman EJ, Kalapurakal JA, Ehrlich PF, Biegel J, Huff V, Warwick AB, Paulino A  et al.  Rhabdoid Tumor of the Kidney and Soft Tissues: Results from National Wilms Tumor Study-5 and Children's Oncology Group Study AREN0321.  Pediatr Blood Cancer  2025 Mar;72(3):e31490. doi:10.1002/pbc.31490
  7. Morshed RA, Nguyen MP, Youngblood MW, Perlow HK, Lucas CG, Patel AJ, Palmer JD, Chandler JP, Theodosopoulos PV, Magill ST  et al.  Gene Expression Changes Associated With Recurrence After Gross Total Resection of Newly Diagnosed World Health Organization Grade 1 Meningioma.  Neurosurgery  2025 Mar 01;96(3):521-528. doi:10.1227/neu.0000000000003133
  8. Xia Y, Papali P, Al-Mistarehi AH, Hansen LJ, Azad TD, Ahmed AK, Meyer C, Gross J, Khan M, Bettegowda C  et al.  Outcomes After Definitive Surgery for Spinal and Sacral Chordoma in 101 Patients Over 20 Years.  Neurosurgery  2025 Mar 01;96(3):494-504. doi:10.1227/neu.0000000000003130
  9. Sears TK, Wang W, Drumm M, Unruh D, McCord M, Horbinski C  F3 Expression Drives Sensitivity to the Antibody-Drug Conjugate Tisotumab Vedotin in Glioblastoma.  Cancers (Basel)  2025 Feb 27;17(5). pii:834
  10. Tripathy A, Corkos P, Blouw B, Montgomery DA, Moore M, Hedrick MH, Youssef M, Kumthekar PU  Longitudinal CSF Tumor Cell Enumeration and Mutational Analysis as a Driver for Leptomeningeal Disease Management.  Cancers (Basel)  2025 Feb 27;17(5). pii:825
  11. Monsen PJ, Bommi PV, Grigorescu AA, Lauing KL, Mao Y, Berardi P, Zhai L, Ojo O, Penco-Campillo M, Koch T  et al.  Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC).  J Med Chem  2025 Feb 27;68(4):4961-4987. doi:10.1021/acs.jmedchem.5c00026
  12. Tiek D, Song X, Yu X, Wu R, Iglesia R, Catezone A, McCortney K, Walshon J, Horbinski C, Jamshidi P  et al.  Oxidative stress induced protein aggregation via GGCT produced pyroglutamic acid in drug resistant glioblastoma.  iScience  2025 Feb 21;28(2):111769. pii:111769
  13. Li J, Shih LK, Markwell SM, Olson CL, Sullivan DP, Arvanitis C, Ross JL, Lam NG, Nuszen H, Hambardzumyan D  et al.  A clinically relevant model and method to study necrosis as a driving force in glioma restructuring and progression.  Proc Natl Acad Sci U S A  2025 Feb 18;122(7):e2416024122. pii:e2416024122
  14. Nguyen MP, Morshed RA, Youngblood MW, Perlow HK, Lucas CG, Patel AJ, Palmer JD, Horbinski CM, Magill ST, Chen WC  et al.  A targeted gene expression biomarker predicts clinic low-risk meningioma recurrence.  Neuro Oncol  2025 Feb 10;27(2):445-454. doi:10.1093/neuonc/noae198
  15. Sahm F, Aldape KD, Brastianos PK, Brat DJ, Dahiya S, von Deimling A, Giannini C, Gilbert MR, Louis DN, Raleigh DR  et al.  cIMPACT-NOW update 8: Clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas.  Neuro Oncol  2025 Feb 10;27(2):319-330. doi:10.1093/neuonc/noae170
  16. Le Rhun E, Nayak L, Lim-Fat MJ, Rudà R, Pentsova E, Forsyth P, O'Brien BJ, Preusser M, Kumthekar P, Brandsma D  et al.  NANO-LM: An updated scorecard for the clinical assessment of patients with leptomeningeal metastases.  Neuro Oncol  2025 Feb 10;27(2):455-465. doi:10.1093/neuonc/noae171
  17. Garcia-Fabiani MB, Haase S, Banerjee K, Zhu Z, McClellan BL, Mujeeb AA, Li Y, Tronrud CE, Varela ML, West MEJ  et al.  H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Diffuse Hemispheric Gliomas.  bioRxiv  2025 Feb 05;. pii:2023.06.13.544658
  18. Fares J, Petrosyan E, Dmello C, Lukas RV, Stupp R, Lesniak MS  Rethinking metastatic brain cancer as a CNS disease.  Lancet Oncol  2025 Feb;26(2):e111-e121. doi:10.1016/S1470-2045(24)00430-3
  19. Gondi V, Deshmukh S, Brown PD, Wefel JS, Armstrong TS, Tome WA, Gilbert MR, Konski A, Robinson CG, Bovi JA  et al.  Erratum to: Gondi V, Deshmukh S, Brown PD, et al. Sustained Preservation of Cognition and Prevention of Patient-Reported Symptoms With Hippocampal Avoidance During Whole-Brain Radiation Therapy for Brain Metastases: Final Results of NRG Oncology CC001. Int J Radiat Oncol Biol Phys. 2023;117:571-580.  Int J Radiat Oncol Biol Phys  2025 Feb 01;121(2):571-572. doi:10.1016/j.ijrobp.2024.08.041
  20. Khalili BF, Walbert T, Horbinski C, Dixit K, Gururangan K, Thio H, Tate MC, Stupp R, Lukas RV, Templer JW  Levetiracetam and valproic acid in glioma: antiseizure and potential antineoplastic effects.  Future Oncol  2025 Feb;21(4):483-491. doi:10.1080/14796694.2025.2450215
  21. Armstrong AE, Daw NC, Renfro LA, Geller JI, Kalapurakal JA, Khanna G, Paulino AC, Perlman EJ, Ehrlich PF, Gow KW  et al.  Treatment of focal anaplastic Wilms tumor: A report from the Children's Oncology Group AREN0321 and AREN03B2 studies.  Cancer  2025 Jan 15;131(2):e35713. doi:10.1002/cncr.35713
  22. Kotecha R, Akdemir EY, Kutuk T, Ilgin C, Ahluwalia MS, Bi WL, Blakeley J, Dixit KS, Dunn IF, Galanis E  et al.  Benchmarking the Efficacy of Salvage Systemic Therapies for Recurrent Meningioma: A RANO Group Systematic Review and Meta-analysis to Guide Clinical Trial Design.  Neuro Oncol  2025 Jan 14;. pii:noaf009
  23. Zhou X, Xia Q, Wang B, Li J, Liu B, Wang S, Huang M, Zhong R, Cheng SY, Wang X  et al.  USP14 modulates stem-like properties, tumorigenicity, and radiotherapy resistance in glioblastoma stem cells through stabilization of MST4-phosphorylated ALKBH5.  Theranostics  2025;15(6):2293-2314. doi:10.7150/thno.103629
  24. Du R, Zhang J, Lukas RV, Tripathi S, Ahrendsen JT, Curran MA, Dmello C, Zhang P, Stupp R, Rao G  et al.  Is modulation of immune checkpoints on glioblastoma-infiltrating myeloid cells a viable therapeutic strategy?  Neuro Oncol  2025 Jan 12;27(1):33-49. doi:10.1093/neuonc/noae193
  25. Fernandopulle MS, Cotty-Fattal Z, Smith H, Mejia Bautista M, Ahrendsen JT, Jennings LJ, Santana-Santos L, Sukhanova M, Conway K, Primdahl D  et al.  Dual TERT promoter mutations in an oligodendroglioma, IDH-mutant, 1p/19q co-deleted.  J Neuropathol Exp Neurol  2025 Jan 11;. pii:nlae138
  26. Duckett D, Vormittag-Nocito ER, Jamshidi P, Sukhanova M, Parker S, Brat DJ, Jennings LJ, Santana-Santos L  Accurate identification of primary site in tumors of unknown origin (TUO) using DNA methylation.  NPJ Precis Oncol  2025 Jan 10;9(1):8. pii:8
  27. Malhotra J, Mambetsariev I, Gilmore G, Fricke J, Nam A, Gallego N, Chen BT, Chen M, Amini A, Lukas RV  et al.  Targeting CNS Metastases in Non-Small Cell Lung Cancer With Evolving Approaches Using Molecular Markers: A Review.  JAMA Oncol  2025 Jan 01;11(1):60-69. doi:10.1001/jamaoncol.2024.5218
  28. Ziu M, Halasz LM, Kumthekar PU, McGranahan TM, Lo SS, Olson JJ  Congress of Neurological Surgeons systematic review and evidence-based guidelines for the role of chemotherapy in newly diagnosed WHO Grade II diffuse glioma in adults: update.  J Neurooncol  2025 Jan;171(2):279-298. doi:10.1007/s11060-024-04861-6
  29. Smith H, Jean J, Duckett D, Vormittag-Nocito E, Nezami BG, Jennings LJ, Ahrendsen JT, Yang XJ, Primdahl D, Conway K  et al.  Diagnostic utility of multimodal advanced molecular testing to classify metastases of unknown primaries: A case of a patient with no known medical history.  J Neuropathol Exp Neurol  2025 Jan 01;84(1):84-86. doi:10.1093/jnen/nlae086
  30. Gould A, Luan Y, Hou Y, Korobova FV, Chen L, Arrieta VA, Amidei C, Ward R, Gomez C, Castro B  et al.  Endothelial response to blood-brain barrier disruption in the human brain.  JCI Insight  2024 Dec 26;10(4). pii:e187328
  31. Dmello C, Brenner A, Piccioni D, Wen PY, Drappatz J, Mrugala M, Lewis LD, Schiff D, Fadul CE, Chamberlain M  et al.  Phase II trial of blood-brain barrier permeable peptide-paclitaxel conjugate ANG1005 in patients with recurrent high-grade glioma.  Neurooncol Adv  2024;6(1):vdae186. pii:vdae186
  32. Baskaran AB, Kozel OA, Venkatesh O, Wainwright DA, Sonabend AM, Heimberger AB, Lukas RV  Immune Checkpoint Inhibitors in Glioblastoma IDHwt Treatment: A Systematic Review.  Cancers (Basel)  2024 Dec 12;16(24). pii:4148
  33. Geng Y, DeLay SL, Chen X, Miska J  It Is Not Just About Storing Energy: The Multifaceted Role of Creatine Metabolism on Cancer Biology and Immunology.  Int J Mol Sci  2024 Dec 11;25(24). pii:13273
  34. Seblani M, Zannikou M, Duffy J, Levine R, Thakur A, Puigdelloses-Vallcorba M, Horbinski C, Miska J, Hambardzumyan D, Becher O  et al.  IL13RA2-integrated genetically engineered mouse model allows for CAR T cells targeting pediatric high-grade gliomas.  Res Sq  2024 Dec 11;. pii:rs.3.rs-5398280
  35. Moawad AW, Janas A, Baid U, Ramakrishnan D, Saluja R, Ashraf N, Maleki N, Jekel L, Yordanov N, Fehringer P  et al.  The Brain Tumor Segmentation - Metastases (BraTS-METS) Challenge 2023: Brain Metastasis Segmentation on Pre-treatment MRI.  ArXiv  2024 Dec 09;. pii:arXiv:2306.00838v3
  36. Leclair NK, Choudury A, Chen WC, Magill ST, McCortney K, Horbinski CM, Chen Z, Goldschmidt E, Eaton CD, Bulsara KR  et al.  RNA splicing as a biomarker and phenotypic driver of meningioma DNA-methylation groups.  Neuro Oncol  2024 Dec 05;26(12):2222-2236. doi:10.1093/neuonc/noae150
  37. Sarkaria JN, Ballman KV, Kizilbash SH, Sulman EP, Giannini C, Friday BB, Butowski NA, Mohile NA, Piccioni DE, Battiste JD  et al.  Efficacy of Adding Veliparib to Temozolomide for Patients With MGMT-Methylated Glioblastoma: A Randomized Clinical Trial.  JAMA Oncol  2024 Dec 01;10(12):1637-1644. doi:10.1001/jamaoncol.2024.4361
  38. Dean DC, Tisdall MD, Wisnowski JL, Feczko E, Gagoski B, Alexander AL, Edden RAE, Gao W, Hendrickson TJ, Howell BR  et al.  Quantifying brain development in the HEALthy Brain and Child Development (HBCD) Study: The magnetic resonance imaging and spectroscopy protocol.  Dev Cogn Neurosci  2024 Dec;70:101452. pii:101452
  39. Thirunavu V, Drumm M, McCord M, Steffens A, Youngblood MW, Nandoliya KR, Smith H, Walshon J, McCortney K, Magill ST  et al.  Optimizing the use of Ki-67 proliferative index as a prognostic biomarker in meningiomas using digital analysis.  J Neurosurg  2024 Dec 01;141(6):1644-1654. doi:10.3171/2024.4.JNS232857
  40. Kostelecky N, Wadhwani N, Golubovich I, Vormittag-Nocito E, Gao J, Jennings L, Caron M, Jamshidi P, Ahrendsen JT, Castellani R  et al.  Transdifferentiation of metastatic melanoma into cerebellar angiosarcoma.  J Neuropathol Exp Neurol  2024 Dec 01;83(12):1081-1083. doi:10.1093/jnen/nlae075
  41. Verly G, Delfino T, Bresciani L, Oliveira M, Oyon D, Chandler J, Galvão GDF  Supratotal Resection Versus Gross Total Resection for Isocitrate Dehydrogenase-Wildtype Glioblastoma and Grade 4 Isocitrate Dehydrogenase-Mutant Astrocytoma: Meta-Analysis of Individual Patient Data.  Oper Neurosurg (Hagerstown)  2024 Nov 18;. doi:10.1227/ons.0000000000001434
  42. Ross JL, Puigdelloses-Vallcorba M, Piñero G, Soni N, Thomason W, DeSisto J, Angione A, Tsankova NM, Castro MG, Schniederjan M  et al.  Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations.  Immunity  2024 Nov 12;57(11):2669-2687.e6. doi:10.1016/j.immuni.2024.09.007
  43. Kim KS, Habashy K, Gould A, Zhao J, Najem H, Amidei C, Saganty R, Arrieta VA, Dmello C, Chen L  et al.  Fc-enhanced anti-CTLA-4, anti-PD-1, doxorubicin, and ultrasound-mediated blood-brain barrier opening: A novel combinatorial immunotherapy regimen for gliomas.  Neuro Oncol  2024 Nov 04;26(11):2044-2060. doi:10.1093/neuonc/noae135
  44. Nandoliya KR, Congivaram H, Youngblood MW, Chen WC, Chaliparambil RK, Horbinski CM, Choudhury A, Brat DJ, Chandler JP, Magill ST  et al.  Clinical and methylomic features of spinal meningiomas.  J Neurooncol  2024 Nov;170(2):277-287. doi:10.1007/s11060-024-04736-w
  45. Giordano A, Kumthekar PU, Jin Q, Binboga Kurt B, Ren S, Li T, Leone JP, Mittendorf EA, Pereslete AM, Sharp L  et al.  A Phase II Study of Atezolizumab, Pertuzumab, and High-Dose Trastuzumab for Central Nervous System Metastases in Patients with HER2-Positive Breast Cancer.  Clin Cancer Res  2024 Nov 01;30(21):4856-4865. doi:10.1158/1078-0432.CCR-24-1161
  46. Wang JZ, Patil V, Landry AP, Gui C, Ajisebutu A, Liu J, Saarela O, Pugh SL, Won M, Patel Z  et al.  Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma.  Nat Med  2024 Nov;30(11):3173-3183. doi:10.1038/s41591-024-03167-4
  47. Cohen-Nowak AJ, Hill VB, Kumthekar P  Diagnostics and Screening in Breast Cancer with Brain and Leptomeningeal Metastasis: A Review of the Literature.  Cancers (Basel)  2024 Oct 31;16(21). pii:3686
  48. Tan S, Zhang Q, Zhan R, Luo S, Han Y, Yu B, Muss C, Pingault V, Marlin S, Delahaye A  et al.  Monoallelic loss-of-function variants in GSK3B lead to autism and developmental delay.  Mol Psychiatry  2024 Oct 29;. doi:10.1038/s41380-024-02806-z
  49. Elghetany MT, Pan JL, Sekar K, Major A, Mf Su J, Adesina A, Hui KM, Li XN, Teo WY  Re-programming by a six-factor-secretome in the patient tumor ecosystem during nutrient stress and drug response.  iScience  2024 Oct 18;27(10):110932. pii:110932
  50. Choudhury A, Cady MA, Lucas CG, Najem H, Phillips JJ, Palikuqi B, Zakimi N, Joseph T, Birrueta JO, Chen WC  et al.  Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy.  Cancer Discov  2024 Oct 04;14(10):1823-1837. doi:10.1158/2159-8290.CD-23-1459
These are the publications from our team members that have been most recently indexed by PubMed. Visit PubMed to see more of our publications.

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