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Recent Publications

Browse recent studies from the Lou and Jean Malnati Brain Tumor Institute to learn more about our cutting-edge research.

  1. Dean DC, Tisdall MD, Wisnowski JL, Feczko E, Gagoski B, Alexander AL, Edden RAE, Gao W, Hendrickson TJ, Howell BR  et al.  Quantifying brain development in the HEALthy Brain and Child Development (HBCD) Study: The magnetic resonance imaging and spectroscopy protocol.  Dev Cogn Neurosci  2024 Dec;70:101452. pii:101452
  2. Thirunavu V, Drumm M, McCord M, Steffens A, Youngblood MW, Nandoliya KR, Smith H, Walshon J, McCortney K, Magill ST  et al.  Optimizing the use of Ki-67 proliferative index as a prognostic biomarker in meningiomas using digital analysis.  J Neurosurg  2024 Dec 01;141(6):1644-1654. doi:10.3171/2024.4.JNS232857
  3. Kostelecky N, Wadhwani N, Golubovich I, Vormittag-Nocito E, Gao J, Jennings L, Caron M, Jamshidi P, Ahrendsen JT, Castellani R  et al.  Transdifferentiation of metastatic melanoma into cerebellar angiosarcoma.  J Neuropathol Exp Neurol  2024 Dec 01;83(12):1081-1083. doi:10.1093/jnen/nlae075
  4. Malhotra J, Mambetsariev I, Gilmore G, Fricke J, Nam A, Gallego N, Chen BT, Chen M, Amini A, Lukas RV  et al.  Targeting CNS Metastases in Non-Small Cell Lung Cancer With Evolving Approaches Using Molecular Markers: A Review.  JAMA Oncol  2024 Nov 27;. doi:10.1001/jamaoncol.2024.5218
  5. Ziu M, Halasz LM, Kumthekar PU, McGranahan TM, Lo SS, Olson JJ  Congress of Neurological Surgeons systematic review and evidence-based guidelines for the role of chemotherapy in newly diagnosed WHO Grade II diffuse glioma in adults: update.  J Neurooncol  2024 Nov 20;. doi:10.1007/s11060-024-04861-6
  6. Ross JL, Puigdelloses-Vallcorba M, Piñero G, Soni N, Thomason W, DeSisto J, Angione A, Tsankova NM, Castro MG, Schniederjan M  et al.  Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations.  Immunity  2024 Nov 12;57(11):2669-2687.e6. doi:10.1016/j.immuni.2024.09.007
  7. Kim KS, Habashy K, Gould A, Zhao J, Najem H, Amidei C, Saganty R, Arrieta VA, Dmello C, Chen L  et al.  Fc-enhanced anti-CTLA-4, anti-PD-1, doxorubicin, and ultrasound-mediated blood-brain barrier opening: A novel combinatorial immunotherapy regimen for gliomas.  Neuro Oncol  2024 Nov 04;26(11):2044-2060. doi:10.1093/neuonc/noae135
  8. Nandoliya KR, Congivaram H, Youngblood MW, Chen WC, Chaliparambil RK, Horbinski CM, Choudhury A, Brat DJ, Chandler JP, Magill ST  et al.  Clinical and methylomic features of spinal meningiomas.  J Neurooncol  2024 Nov;170(2):277-287. doi:10.1007/s11060-024-04736-w
  9. Giordano A, Kumthekar PU, Jin Q, Binboga Kurt B, Ren S, Li T, Leone JP, Mittendorf EA, Pereslete AM, Sharp L  et al.  A Phase II Study of Atezolizumab, Pertuzumab, and High-Dose Trastuzumab for Central Nervous System Metastases in Patients with HER2-Positive Breast Cancer.  Clin Cancer Res  2024 Nov 01;30(21):4856-4865. doi:10.1158/1078-0432.CCR-24-1161
  10. Wang JZ, Patil V, Landry AP, Gui C, Ajisebutu A, Liu J, Saarela O, Pugh SL, Won M, Patel Z  et al.  Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma.  Nat Med  2024 Nov;30(11):3173-3183. doi:10.1038/s41591-024-03167-4
  11. Cohen-Nowak AJ, Hill VB, Kumthekar P  Diagnostics and Screening in Breast Cancer with Brain and Leptomeningeal Metastasis: A Review of the Literature.  Cancers (Basel)  2024 Oct 31;16(21). pii:3686
  12. Sarkaria JN, Ballman KV, Kizilbash SH, Sulman EP, Giannini C, Friday BB, Butowski NA, Mohile NA, Piccioni DE, Battiste JD  et al.  Efficacy of Adding Veliparib to Temozolomide for Patients With MGMT-Methylated Glioblastoma: A Randomized Clinical Trial.  JAMA Oncol  2024 Oct 31;. pii:e244361
  13. Tan S, Zhang Q, Zhan R, Luo S, Han Y, Yu B, Muss C, Pingault V, Marlin S, Delahaye A  et al.  Monoallelic loss-of-function variants in GSK3B lead to autism and developmental delay.  Mol Psychiatry  2024 Oct 29;. doi:10.1038/s41380-024-02806-z
  14. Du R, Zhang J, Lukas RV, Tripathi S, Ahrendsen JT, Curran MA, Dmello C, Zhang P, Stupp R, Rao G  et al.  Is modulation of immune checkpoints on glioblastoma-infiltrating myeloid cells a viable therapeutic strategy?  Neuro Oncol  2024 Oct 19;. pii:noae193
  15. Elghetany MT, Pan JL, Sekar K, Major A, Mf Su J, Adesina A, Hui KM, Li XN, Teo WY  Re-programming by a six-factor-secretome in the patient tumor ecosystem during nutrient stress and drug response.  iScience  2024 Oct 18;27(10):110932. pii:110932
  16. Choudhury A, Cady MA, Lucas CG, Najem H, Phillips JJ, Palikuqi B, Zakimi N, Joseph T, Birrueta JO, Chen WC  et al.  Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy.  Cancer Discov  2024 Oct 04;14(10):1823-1837. doi:10.1158/2159-8290.CD-23-1459
  17. van den Bent MJ, French PJ, Brat D, Tonn JC, Touat M, Ellingson BM, Young RJ, Pallud J, von Deimling A, Sahm F  et al.  The biological significance of tumor grade, age, enhancement, and extent of resection in IDH-mutant gliomas: How should they inform treatment decisions in the era of IDH inhibitors?  Neuro Oncol  2024 Oct 03;26(10):1805-1822. doi:10.1093/neuonc/noae107
  18. Wilcox JA, Chukwueke UN, Ahn MJ, Aizer AA, Bale TA, Brandsma D, Brastianos PK, Chang S, Daras M, Forsyth P  et al.  Leptomeningeal metastases from solid tumors: A Society for Neuro-Oncology and American Society of Clinical Oncology consensus review on clinical management and future directions.  Neuro Oncol  2024 Oct 03;26(10):1781-1804. doi:10.1093/neuonc/noae103
  19. Schwartz C, Ueberschaer MF, Rautalin I, Grauvogel J, Bissolo M, Masalha W, Steiert C, Schnell O, Beck J, Ebel F  et al.  Frailty indices predict mortality, complications and functional improvements in supratentorial meningioma patients over 80 years of age.  J Neurooncol  2024 Oct;170(1):89-100. doi:10.1007/s11060-024-04780-6
  20. Nguyen MP, Morshed RA, Youngblood MW, Perlow HK, Lucas CG, Patel AJ, Palmer JD, Horbinski CM, Magill ST, Chen WC  et al.  A targeted gene expression biomarker predicts clinic low-risk meningioma recurrence.  Neuro Oncol  2024 Sep 28;. pii:noae198
  21. Katz JL, Geng Y, Billingham LK, Sadagopan NS, DeLay SL, Subbiah J, Chia TY, McManus G, Wei C, Wang H  et al.  A covalent creatine kinase inhibitor ablates glioblastoma migration and sensitizes tumors to oxidative stress.  Sci Rep  2024 Sep 20;14(1):21959. pii:21959
  22. Kim KS, Zhang J, Arrieta VA, Dmello C, Grabis E, Habashy K, Duffy J, Zhao J, Gould A, Chen L  et al.  MAPK/ERK signaling in gliomas modulates interferon responses, T cell recruitment, microglia phenotype, and immune checkpoint blockade efficacy.  bioRxiv  2024 Sep 18;. pii:2024.09.11.612571
  23. Schubert MC, Soyka SJ, Tamimi A, Maus E, Schroers J, Wißmann N, Reyhan E, Tetzlaff SK, Yang Y, Denninger R  et al.  Deep intravital brain tumor imaging enabled by tailored three-photon microscopy and analysis.  Nat Commun  2024 Sep 10;15(1):7383. pii:7383
  24. Zhang X, Duan S, Apostolou PE, Wu X, Watanabe J, Gallitto M, Barron T, Taylor KR, Woo PJ, Hua X  et al.  CHD2 Regulates Neuron-Glioma Interactions in Pediatric Glioma.  Cancer Discov  2024 Sep 04;14(9):1732-1754. doi:10.1158/2159-8290.CD-23-0012
  25. Panek WK, Toedebusch RG, Mclaughlin BE, Dickinson PJ, Van Dyke JE, Woolard KD, Berens ME, Lesniak MS, Sturges BK, Vernau KM  et al.  The CCL2-CCR4 axis promotes Regulatory T cell trafficking to canine glioma tissues.  J Neurooncol  2024 Sep;169(3):647-658. doi:10.1007/s11060-024-04766-4
  26. Li X, Nguyen TTA, Zhang J, Nayak A, Liu Y, Duckworth LA, Zhang G, Bakkar R, Agarwal I, Hou Y  et al.  Validation Study of the Newly Proposed Refined Diagnostic Criteria for Malignant Phyllodes Tumor With 136 Borderline and Malignant Phyllodes Tumor Cases.  Am J Surg Pathol  2024 Sep 01;48(9):1146-1153. doi:10.1097/PAS.0000000000002264
  27. Sahm F, Aldape KD, Brastianos PK, Brat DJ, Dahiya S, von Deimling A, Giannini C, Gilbert MR, Louis DN, Raleigh DR  et al.  cIMPACT-NOW Update 8: Clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas.  Neuro Oncol  2024 Aug 30;. pii:noae170
  28. Le Rhun E, Nayak L, Lim-Fat MJ, Rudà R, Pentsova E, Forsyth P, O'Brien BJ, Preusser M, Kumthekar P, Brandsma D  et al.  NANO-LM: An updated scorecard for the clinical assessment of patients with leptomeningeal metastases.  Neuro Oncol  2024 Aug 29;. pii:noae171
  29. Wang S, Castro BA, Katz JL, Arrieta V, Najem H, Vazquez-Cervantes GI, Wan H, Olson IE, Hou D, Dapash M  et al.  B cell-based therapy produces antibodies that inhibit glioblastoma growth.  J Clin Invest  2024 Aug 29;134(20). pii:e177384
  30. An S, McCortney K, Walshon J, Leonard K, Wray B, McCord M, DeCuypere M, Horbinski C  Methylation profiling of plasma cell-free DNA in pediatric brain tumor patients.  Acta Neuropathol  2024 Aug 26;148(1):29. doi:10.1007/s00401-024-02795-x
  31. Tripathi S, Najem H, Dussold C, Pacheco S, Du R, Sooreshjani M, Hurley L, Chandler JP, Stupp R, Sonabend AM  et al.  Pediatric glioma immune profiling identifies TIM3 as a therapeutic target in BRAF fusion pilocytic astrocytoma.  J Clin Invest  2024 Aug 13;134(19). pii:e177413
  32. Morshed RA, Nguyen MP, Youngblood MW, Perlow HK, Lucas CG, Patel AJ, Palmer JD, Chandler JP, Theodosopoulos PV, Magill ST  et al.  Gene Expression Changes Associated With Recurrence After Gross Total Resection of Newly Diagnosed World Health Organization Grade 1 Meningioma.  Neurosurgery  2024 Aug 05;. doi:10.1227/neu.0000000000003133
  33. Xia Y, Papali P, Al-Mistarehi AH, Hansen LJ, Azad TD, Ahmed AK, Meyer C, Gross J, Khan M, Bettegowda C  et al.  Outcomes After Definitive Surgery for Spinal and Sacral Chordoma in 101 Patients Over 20 Years.  Neurosurgery  2024 Aug 05;. doi:10.1227/neu.0000000000003130
  34. Budhiraja S, McManus G, Baisiwala S, Perrault EN, Cho S, Saathoff M, Chen L, Park CH, Kazi HA, Dmello C  et al.  ARF4-mediated retrograde trafficking as a driver of chemoresistance in glioblastoma.  Neuro Oncol  2024 Aug 05;26(8):1421-1437. doi:10.1093/neuonc/noae059
  35. Leclair NK, Choudury A, Chen WC, Magill ST, McCortney K, Horbinski CM, Chen Z, Goldschmidt E, Eaton CD, Bulsara KR  et al.  RNA splicing as a biomarker and phenotypic driver of meningioma DNA methylation groups.  Neuro Oncol  2024 Aug 02;. pii:noae150
  36. Mrugala MM, Shi W, Iwomoto F, Lukas RV, Palmer JD, Suh JH, Glas M  Global post‑marketing safety surveillance of Tumor Treating Fields (TTFields) therapy in over 25,000 patients with CNS malignancies treated between 2011-2022.  J Neurooncol  2024 Aug;169(1):25-38. doi:10.1007/s11060-024-04682-7
  37. Yang Y, Wadhwani N, Shimomura A, Zheng S, Chandler J, Lesniak MS, Tate MC, Sonabend AM, Kalapurakal J, Horbinski C  et al.  Long-term outcomes of central neurocytoma - an institutional experience.  J Neurooncol  2024 Aug;169(1):195-201. doi:10.1007/s11060-024-04713-3
  38. Xu C, Chen G, Yu B, Sun B, Zhang Y, Zhang M, Yang Y, Xiao Y, Cheng SY, Li Y  et al.  TRIM24 Cooperates with Ras Mutation to Drive Glioma Progression through snoRNA Recruitment of PHAX and DNA-PKcs.  Adv Sci (Weinh)  2024 Aug;11(29):e2400023. pii:2400023
  39. Raleigh DR, Chen WC, Gondi V, Rogers L, Mehta M  Implications and interchangeability of meningioma biomarkers for clinical trials and clinical practice.  J Neurooncol  2024 Aug;169(1):215-217. doi:10.1007/s11060-024-04700-8
  40. Smith H, Jean J, Duckett D, Vormittag-Nocito E, Nezami BG, Jennings LJ, Ahrendsen JT, Yang XJ, Primdahl D, Conway K  et al.  Diagnostic utility of multimodal advanced molecular testing to classify metastases of unknown primaries: A case of a patient with no known medical history.  J Neuropathol Exp Neurol  2024 Jul 31;. pii:nlae086
  41. Nandoliya KR, Vignolles-Jeong J, Karras CL, Govind S, Finger G, Thirunavu V, Sonabend AM, Magill ST, Prevedello DM, Chandler JP  Clinical characteristics and outcomes after trigeminal schwannoma resection: a multi-institutional experience.  Neurosurg Rev  2024 Jul 18;47(1):340. doi:10.1007/s10143-024-02550-6
  42. Liggett MR, Lashley S, Gill NP, Scholtens DM, Dawood ZS, Alam HB  Plasma therapy for traumatic brain injury: Rationale for a prospective randomized trial.  Transfusion  2024 Jul;64(7):1362-1371. doi:10.1111/trf.17928
  43. Lyons CE, Dixit K  Elsberg Syndrome: A Case Report of a Novel Radiographic Presentation.  Neurohospitalist  2024 Jul;14(3):347-350. doi:10.1177/19418744241241107
  44. Qi L, Du Y, Huang Y, Kogiso M, Zhang H, Xiao S, Abdallah A, Suarez M, Niu L, Liu ZG  et al.  CD57 defines a novel cancer stem cell that drive invasion of diffuse pediatric-type high grade gliomas.  Br J Cancer  2024 Jul;131(2):258-270. doi:10.1038/s41416-024-02724-5
  45. Rudà R, Horbinski C, van den Bent M, Preusser M, Soffietti R  IDH inhibition in gliomas: from preclinical models to clinical trials.  Nat Rev Neurol  2024 Jul;20(7):395-407. doi:10.1038/s41582-024-00967-7
  46. Huang ZL, Liu ZG, Lin Q, Tao YL, Li X, Baxter P, Su JM, Adesina AM, Man C, Chintagumpala M  et al.  Fractionated radiation therapy alters energy metabolism and induces cellular quiescence exit in patient-derived orthotopic xenograft models of high-grade glioma.  Transl Oncol  2024 Jul;45:101988. pii:101988
  47. Rabin EE, Huang J, Kim M, Mozny A, Lauing KL, Penco-Campillo M, Zhai L, Bommi P, Mi X, Power EA  et al.  Age-stratified comorbid and pharmacologic analysis of patients with glioblastoma.  Brain Behav Immun Health  2024 Jul;38:100753. pii:100753
  48. Benedetti DJ, Renfro LA, Tfirn I, Daw NC, Kalapurakal JA, Ehrlich PF, Khanna G, Perlman E, Warwick A, Gow KW  et al.  Treatment and outcomes of clear cell sarcoma of the kidney: A report from the Children's Oncology Group studies AREN0321 and AREN03B2.  Cancer  2024 Jul 01;130(13):2361-2371. doi:10.1002/cncr.35266
  49. Panek WK, Toedebusch RG, Mclaughlin BE, Dickinson PJ, Dyke JE, Woolard KD, Berens ME, Lesniak MS, Sturges BK, Vernau KM  et al.  The CCL2-CCR4 Axis Promotes Regulatory T Cell Trafficking to Canine Glioma Tissues.  Res Sq  2024 Jun 17;. pii:rs.3.rs-4474288
  50. Najem H, Lea ST, Tripathi S, Hurley L, Chen CH, William I, Sooreshjani M, Bowie M, Hartley G, Dussold C  et al.  STING agonist 8803 reprograms the immune microenvironment and increases survival in preclinical models of glioblastoma.  J Clin Invest  2024 Jun 17;134(12). pii:e175033
These are the publications from our team members that have been most recently indexed by PubMed. Visit PubMed to see more of our publications.

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