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Recent Publications

Browse recent studies from the Lou and Jean Malnati Brain Tumor Institute to learn more about our cutting-edge research.

  1. Tan PH, Ellis IO, Allison KH, Badve SS, Brogi E, Callagy G, Charafe-Jauffret E, Chen CJ, Chen YY, Collins LC  et al.  Malignant phyllodes tumours of the breast: the case for revising WHO's 'full house' diagnostic criteria.  Histopathology  2025 Aug;87(2):169-182. doi:10.1111/his.15455
  2. Xia Y, Papali P, Al-Mistarehi AH, Ahmed AK, Hansen LJ, Meyer C, Gross J, Khan M, Winkle M, Bettegowda C  et al.  Long-term functional outcomes and their relationship to nerve root sacrifice after definitive surgery for sacrococcygeal chordoma.  J Neurosurg Spine  2025 Jul 11;:1-12. doi:10.3171/2025.3.SPINE241408
  3. Liu Y, Pang L, Khan F, Wu J, Zhou F, Horbinski C, Bao S, Yu JS, Lathia JD, Chen P  Glycoprotein NMB mediates bidirectional GSC-TAM interactions to promote tumor progression.  JCI Insight  2025 Jul 08;10(13). pii:e187684
  4. Corn BW, Paulus R, Gondi V, Mehta MP, Fogh S, Wefel JS, Videtic GM, Sun A, Yoon H, Heinzerling JH  et al.  "Hope" Drives Quality of Life in Patients with Brain Metastases, But, the "Hope Center" Remains Elusive: An Analysis of NRG-CC003.  Int J Radiat Oncol Biol Phys  2025 Jul 02;. pii:S0360-3016(25)04519-5
  5. Vormittag-Nocito E, Duckett D, Castellani RJ, Ahrendsen JT, Lu X, Jennings LJ, Lukas RV, Magill ST, Santana-Santos L, Brat DJ  et al.  Meningiomas With Chromosomal Polysomies Reveal Nonrandom Gain of Chromosomes, Distinct Methylation Signature, and Lower Risk of Recurrence.  Mod Pathol  2025 Jul;38(7):100775. doi:10.1016/j.modpat.2025.100775
  6. Cheok SK, Ruzevick J, Briggs RG, Cote DJ, Shah I, Gomez D, Bove I, Feng JJ, Pangal DJ, Strickland BA  et al.  A contemporary, multiinstitutional analysis of transcription factor lineage in pituitary adenomas: comparative study of neuroimaging, histopathology, and clinical outcomes.  J Neurosurg  2025 Jul 01;143(1):146-154. doi:10.3171/2024.10.JNS24853
  7. Fernandopulle MS, Cotty-Fattal Z, Smith H, Mejia Bautista M, Ahrendsen JT, Jennings LJ, Santana-Santos L, Sukhanova M, Conway K, Primdahl D  et al.  Dual TERT promoter mutations in an oligodendroglioma, IDH-mutant, 1p/19q co-deleted.  J Neuropathol Exp Neurol  2025 Jul 01;84(7):658-660. doi:10.1093/jnen/nlae138
  8. Al-Mistarehi AH, Zaitoun KJ, Javed S, Xia Y, Hersh A, Ghaith AK, Weber-Levine C, Jiang K, Khan M, Mendelson B  et al.  Survival and Functional Outcomes Following Surgical Resection of Intramedullary Spinal Cord Tumors: A Series of 253 Patients over 22 Years.  Cancers (Basel)  2025 Jun 24;17(13). pii:2112
  9. Feng Y, Haupt B, Huynh TT, Meshaw R, Martin-Regalado A, Thakur A, Duffy JT, Alzeer A, Siegel DA, Barnes A  et al.  Longitudinal Imaging Reveals Tumor Uptake and Prolonged Retention of Bi-Specific T-Cell Engaging Antibody in GBM via Passive and Active Mechanisms.  Clin Cancer Res  2025 Jun 13;. doi:10.1158/1078-0432.CCR-24-4194
  10. Habashy KJ, Synold TW, Feng Y, Gomez C, Amidei C, Ward R, VanderMolen S, Zarrieneh A, Kim KS, Gomez M  et al.  Pharmacokinetic analysis of carboplatin and fluorescein brain retention following ultrasound-based blood-brain barrier opening.  Clin Cancer Res  2025 Jun 10;. doi:10.1158/1078-0432.CCR-25-0080
  11. Sadagopan NS, Gomez M, Tripathi S, Billingham LK, DeLay SL, Cady MA, Congivaram HTS, Chia TY, Wan H, Wang S  et al.  NOTCH3 Drives Fatty Acid Oxidation and Ferroptosis Resistance in Aggressive Meningiomas.  Res Sq  2025 Jun 04;. pii:rs.3.rs-6779386
  12. Sperduto PW, Marqueen KE, Chang E, Li J, Davies MA, Ebner DK, Breen WG, Lamba N, Shih HA, Edwards D  et al.  Improved Survival and Prognostication in Melanoma Patients With Brain Metastases: An Update of the Melanoma Graded Prognostic Assessment.  J Clin Oncol  2025 Jun;43(16):1910-1919. doi:10.1200/JCO-24-01351
  13. Gruchala T, Lewis CW, Abplanalp K, Jayabalan P, Walunas TL, Johnson JL, Wainwright DA, Lukas RV, Spill G, Roy I  Predicting medical prognosis in patients with glioblastoma during inpatient rehabilitation using bed mobility function.  PM R  2025 May 19;. doi:10.1002/pmrj.13402
  14. Turunen JR, Kumthekar P, Ahmed AU  Beyond the brain: exploring the impact of animal models of leptomeningeal disease from solid tumors.  Acta Neuropathol Commun  2025 May 19;13(1):103. pii:103
  15. Izhar M, Lesniak MS  Role of Extracellular Vesicles in the Pathogenesis of Brain Metastasis.  J Extracell Biol  2025 May;4(5):e70051. pii:e70051
  16. Beck JA, Mazcko C, Belluco S, Bitar M, Brat D, Bush JW, Chkheidze R, Corps KN, Frank C, Giannini C  et al.  Comparative pathology boards facilitate the translation of knowledge between canine and human cancer patients.  Brain Pathol  2025 May 05;:e70013. doi:10.1111/bpa.70013
  17. Pieters TA, Hersh AM, Elsamadicy AA, Pennington Z, Santangelo G, Najjar S, Hung B, Ber R, Atallah C, Efron J  et al.  Outcomes after en bloc resection with sacrectomy of advanced colorectal carcinomas that invade the sacrum: a multiinstitutional descriptive series.  J Neurosurg Spine  2025 May 01;42(5):598-604. doi:10.3171/2024.10.SPINE24391
  18. Tan S, Zhang Q, Zhan R, Luo S, Han Y, Yu B, Muss C, Pingault V, Marlin S, Delahaye A  et al.  Monoallelic loss-of-function variants in GSK3B lead to autism and developmental delay.  Mol Psychiatry  2025 May;30(5):1952-1965. doi:10.1038/s41380-024-02806-z
  19. Hou D, Wang S, Castro BA, Katz JL, Dapash M, Arrieta VA, Vazquez-Cervantes GI, Wan H, Billingham LK, Du R  et al.  Dual αVβ8 Integrin and PD-1 Blockade Overcomes TGFβ-Mediated B-Cell Suppression to Enhance Anti-Glioma Immunity.  Neuro Oncol  2025 Apr 22;. pii:noaf106
  20. Khalili BF, Dixit K, Kamson DO, Horbinski C, Przybyla DJ, Tate MC, Heimberger AB, Lukas RV, Templer JW  The excitatory milieu in glioma: mechanisms and therapeutic avenues.  Neuro Oncol  2025 Apr 18;. pii:noaf063
  21. Lee GY, Glicksman MA, Patel R, Malhotra S, Moelis N, Vanjani NN, Kumthekar P  Retrospective Review of Intra-Cerebrospinal Fluid (CSF) Drug Delivery in CNS Malignancies: Safety, Clinical Efficacy and Pharmacokinetic Profiles of Intracerebroventricular (ICV), Lumbar Intrathecal (LIT), and Intra-Cisterna Magna (ICM) Injections.  Cancers (Basel)  2025 Apr 09;17(8). pii:1263
  22. Seblani M, Zannikou M, Duffy JT, Joshi T, Levine RN, Thakur A, Puigdelloses-Vallcorba M, Horbinski CM, Miska J, Hambardzumyan D  et al.  IL13RA2-integrated genetically engineered mouse model allows for CAR T cells targeting pediatric high-grade gliomas.  Acta Neuropathol Commun  2025 Apr 02;13(1):69. pii:69
  23. Chia TY, Sadagopan NS, Miska J  Lipid peroxidation and immune activation: TRAF3's double-edged strategy against glioblastoma.  J Clin Invest  2025 Apr 01;135(7). pii:e190471
  24. Geurts M, Berchtold L, Koenig F, Nabors B, Reardon DA, Tonn JC, Stupp R, Gorlia T, Weller M, Preusser M  et al.  Temozolomide chemotherapy for patients with newly diagnosed glioblastoma in the CENTRIC EORTC 26071-22072 and CORE trials: Does time of administration matter?  Neurooncol Pract  2025 Apr;12(2):291-300. doi:10.1093/nop/npaf006
  25. Song X, Tiek D, Lu M, Yu X, Wu R, Walker M, He Q, Sisbarro D, Hu B, Cheng SY  A Single-Cell Atlas of RNA Alternative Splicing in the Glioma-Immune Ecosystem.  bioRxiv  2025 Mar 30;. pii:2025.03.26.645511
  26. Yu X, Song X, Tiek D, Wu R, Walker M, Horbinski C, Hu B, Cheng SY  Targeting PDGFRA-SHP2 Signaling Enhances Radiotherapy in IDH1-Mutant Glioma.  Neuro Oncol  2025 Mar 25;. pii:noaf086
  27. Seetharam D, Chandar J, Ramsoomair CK, Desgraves JF, Alvarado Medina A, Hudson AJ, Amidei A, Castro JR, Govindarajan V, Wang S  et al.  Activating antiviral immune responses potentiates immune checkpoint inhibition in glioblastoma models.  J Clin Invest  2025 Mar 17;135(6). pii:e183745
  28. McCord M, Sears T, Wang W, Chaliparambil R, An S, Sarkaria J, James CD, Ruggeri B, Gueble S, Bindra R  et al.  The novel DNA cross-linking agent KL-50 is active against patient-derived models of new and recurrent post-temozolomide mismatch repair-deficient glioblastoma.  Neuro Oncol  2025 Mar 07;27(3):644-651. doi:10.1093/neuonc/noae257
  29. Feng H, Hu B, Vuori K, Sarkaria JN, Furnari FB, Cavenee WK, Cheng S-  Correction: EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180.  Oncogene  2025 Mar;44(10):710-711. doi:10.1038/s41388-025-03290-7
  30. Wu Y, Gao X, Liu Z, Wang P, Wu Z, Li Y, Zhang T, Liu T, Liu T, Li X  Decoding cortical folding patterns in marmosets using machine learning and large language model.  Neuroimage  2025 Mar;308:121031. doi:10.1016/j.neuroimage.2025.121031
  31. Pedder JH, Sonabend AM, Cearns MD, Michael BD, Zakaria R, Heimberger AB, Jenkinson MD, Dickens D  Crossing the blood-brain barrier: emerging therapeutic strategies for neurological disease.  Lancet Neurol  2025 Mar;24(3):246-260. doi:10.1016/S1474-4422(24)00476-9
  32. Geller JI, Renfro LA, Grundy PE, Perlman EJ, Kalapurakal JA, Ehrlich PF, Biegel J, Huff V, Warwick AB, Paulino A  et al.  Rhabdoid Tumor of the Kidney and Soft Tissues: Results from National Wilms Tumor Study-5 and Children's Oncology Group Study AREN0321.  Pediatr Blood Cancer  2025 Mar;72(3):e31490. doi:10.1002/pbc.31490
  33. Morshed RA, Nguyen MP, Youngblood MW, Perlow HK, Lucas CG, Patel AJ, Palmer JD, Chandler JP, Theodosopoulos PV, Magill ST  et al.  Gene Expression Changes Associated With Recurrence After Gross Total Resection of Newly Diagnosed World Health Organization Grade 1 Meningioma.  Neurosurgery  2025 Mar 01;96(3):521-528. doi:10.1227/neu.0000000000003133
  34. Xia Y, Papali P, Al-Mistarehi AH, Hansen LJ, Azad TD, Ahmed AK, Meyer C, Gross J, Khan M, Bettegowda C  et al.  Outcomes After Definitive Surgery for Spinal and Sacral Chordoma in 101 Patients Over 20 Years.  Neurosurgery  2025 Mar 01;96(3):494-504. doi:10.1227/neu.0000000000003130
  35. Sears TK, Wang W, Drumm M, Unruh D, McCord M, Horbinski C  F3 Expression Drives Sensitivity to the Antibody-Drug Conjugate Tisotumab Vedotin in Glioblastoma.  Cancers (Basel)  2025 Feb 27;17(5). pii:834
  36. Tripathy A, Corkos P, Blouw B, Montgomery DA, Moore M, Hedrick MH, Youssef M, Kumthekar PU  Longitudinal CSF Tumor Cell Enumeration and Mutational Analysis as a Driver for Leptomeningeal Disease Management.  Cancers (Basel)  2025 Feb 27;17(5). pii:825
  37. Monsen PJ, Bommi PV, Grigorescu AA, Lauing KL, Mao Y, Berardi P, Zhai L, Ojo O, Penco-Campillo M, Koch T  et al.  Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC).  J Med Chem  2025 Feb 27;68(4):4961-4987. doi:10.1021/acs.jmedchem.5c00026
  38. Fan X, Wang H, Lv X, Wang Q, Yu B, Li X, Li L, Zhang Y, Ma N, Lu Q  et al.  The pCREB/BDNF Pathway in the Hippocampus Is Involved in the Therapeutic Effect of Selective 5-HT Reuptake Inhibitors in Adult Male Rats Exposed to Blast Traumatic Brain Injury.  Brain Sci  2025 Feb 24;15(3). pii:236
  39. Tiek D, Song X, Yu X, Wu R, Iglesia R, Catezone A, McCortney K, Walshon J, Horbinski C, Jamshidi P  et al.  Oxidative stress induced protein aggregation via GGCT produced pyroglutamic acid in drug resistant glioblastoma.  iScience  2025 Feb 21;28(2):111769. pii:111769
  40. Li J, Shih LK, Markwell SM, Olson CL, Sullivan DP, Arvanitis C, Ross JL, Lam NG, Nuszen H, Hambardzumyan D  et al.  A clinically relevant model and method to study necrosis as a driving force in glioma restructuring and progression.  Proc Natl Acad Sci U S A  2025 Feb 18;122(7):e2416024122. pii:e2416024122
  41. Nguyen MP, Morshed RA, Youngblood MW, Perlow HK, Lucas CG, Patel AJ, Palmer JD, Horbinski CM, Magill ST, Chen WC  et al.  A targeted gene expression biomarker predicts clinic low-risk meningioma recurrence.  Neuro Oncol  2025 Feb 10;27(2):445-454. doi:10.1093/neuonc/noae198
  42. Sahm F, Aldape KD, Brastianos PK, Brat DJ, Dahiya S, von Deimling A, Giannini C, Gilbert MR, Louis DN, Raleigh DR  et al.  cIMPACT-NOW update 8: Clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas.  Neuro Oncol  2025 Feb 10;27(2):319-330. doi:10.1093/neuonc/noae170
  43. Le Rhun E, Nayak L, Lim-Fat MJ, Rudà R, Pentsova E, Forsyth P, O'Brien BJ, Preusser M, Kumthekar P, Brandsma D  et al.  NANO-LM: An updated scorecard for the clinical assessment of patients with leptomeningeal metastases.  Neuro Oncol  2025 Feb 10;27(2):455-465. doi:10.1093/neuonc/noae171
  44. Garcia-Fabiani MB, Haase S, Banerjee K, Zhu Z, McClellan BL, Mujeeb AA, Li Y, Tronrud CE, Varela ML, West MEJ  et al.  H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Diffuse Hemispheric Gliomas.  bioRxiv  2025 Feb 05;. pii:2023.06.13.544658
  45. Fares J, Petrosyan E, Dmello C, Lukas RV, Stupp R, Lesniak MS  Rethinking metastatic brain cancer as a CNS disease.  Lancet Oncol  2025 Feb;26(2):e111-e121. doi:10.1016/S1470-2045(24)00430-3
  46. Gondi V, Deshmukh S, Brown PD, Wefel JS, Armstrong TS, Tome WA, Gilbert MR, Konski A, Robinson CG, Bovi JA  et al.  Erratum to: Gondi V, Deshmukh S, Brown PD, et al. Sustained Preservation of Cognition and Prevention of Patient-Reported Symptoms With Hippocampal Avoidance During Whole-Brain Radiation Therapy for Brain Metastases: Final Results of NRG Oncology CC001. Int J Radiat Oncol Biol Phys. 2023;117:571-580.  Int J Radiat Oncol Biol Phys  2025 Feb 01;121(2):571-572. doi:10.1016/j.ijrobp.2024.08.041
  47. Khalili BF, Walbert T, Horbinski C, Dixit K, Gururangan K, Thio H, Tate MC, Stupp R, Lukas RV, Templer JW  Levetiracetam and valproic acid in glioma: antiseizure and potential antineoplastic effects.  Future Oncol  2025 Feb;21(4):483-491. doi:10.1080/14796694.2025.2450215
  48. Sloan AR, Gordillo AJ, Kennemer A, Khorana AA, Horbinski C, Kaelber DC, Cameron SJ, Lathia JD  Venous thromboembolism incidence shortens survival in isocitrate dehydrogenase wild-type glioblastoma.  Neurooncol Adv  2025;7(1):vdaf018. pii:vdaf018
  49. Armstrong AE, Daw NC, Renfro LA, Geller JI, Kalapurakal JA, Khanna G, Paulino AC, Perlman EJ, Ehrlich PF, Gow KW  et al.  Treatment of focal anaplastic Wilms tumor: A report from the Children's Oncology Group AREN0321 and AREN03B2 studies.  Cancer  2025 Jan 15;131(2):e35713. doi:10.1002/cncr.35713
  50. Kotecha R, Akdemir EY, Kutuk T, Ilgin C, Ahluwalia MS, Bi WL, Blakeley J, Dixit KS, Dunn IF, Galanis E  et al.  Benchmarking the Efficacy of Salvage Systemic Therapies for Recurrent Meningioma: A RANO Group Systematic Review and Meta-analysis to Guide Clinical Trial Design.  Neuro Oncol  2025 Jan 14;. pii:noaf009
These are the publications from our team members that have been most recently indexed by PubMed. Visit PubMed to see more of our publications.

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