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Recent Publications

Browse recent studies from the Lou and Jean Malnati Brain Tumor Institute to learn more about our cutting-edge research.

  1. He Z, Li W, Liu T, Li X, Han J, Zhang T, Yuan Y  GAGM: Geometry-aware graph matching framework for weakly supervised gyral hinge correspondence.  Med Image Anal  2026 Jan;107(Pt A):103820. doi:10.1016/j.media.2025.103820
  2. Sadagopan NS, Gomez M, Tripathi S, Billingham LK, DeLay SL, Cady MA, Congivaram HTS, Chia TY, Wan H, Wang S  et al.  NOTCH3 drives fatty acid oxidation and ferroptosis resistance in aggressive meningiomas.  J Neurooncol  2025 Dec;175(3):979-991. doi:10.1007/s11060-025-05208-5
  3. Jin Z, Li X, Hou X, Hu J, Zhuo Y, Shi J, Xu T, Zhao Q, Jing Z  Single-atom Ca nanozyme induces glioma death through Ca2+-overload-enhanced catalytic tumor nanotherapy, ferroptosis and synergistic remodeling of the immune microenvironment.  J Nanobiotechnology  2025 Nov 13;23(1):716. doi:10.1186/s12951-025-03798-w
  4. Mahajan AS, Dussold C, Kim S, Jarvis R, Hurley LA, Tommasini-Ghelfi S, Park J, Forsyth CM, Zhang B, Miska J  et al.  cGAS-agonistic spherical nucleic acids reprogram the glioblastoma immune microenvironment and promote antitumor immunity.  Proc Natl Acad Sci U S A  2025 Nov 11;122(45):e2409557122. doi:10.1073/pnas.2409557122
  5. Tiek D, Song X, Wu R, Yu X, Walker M, Mao Y, Sisbarro D, He Q, Magassa A, Singh A  et al.  Cysteine addiction in drug resistant glioblastoma and therapeutic targeting with designer selenium compounds.  Neuro Oncol  2025 Nov 10;. pii:noaf265
  6. Gondi V, Pugh SL, Mehta MP, Wefel JS, Tomé WA, Sun AY, Grecula J, Redmond KJ, Fogh S, Gaspar L  et al.  Hippocampal Avoidance During Prophylactic Cranial Irradiation for Patients With Small Cell Lung Cancer: Randomized Phase II/III Trial NRG-CC003.  J Clin Oncol  2025 Nov 10;43(32):3516-3525. doi:10.1200/JCO-25-00221
  7. De La Fuente MI, Brastianos PK, Gampel B, Nassiri F, Raleigh DR, Ida CM, Abdelbaki MS, Pekmezci M, Bagley S, Young JS  et al.  Reflecting on Scientific Growth and Innovation as the Society for Neuro-Oncology Turns 30.  Neuro Oncol  2025 Nov 04;. pii:noaf255
  8. Khalili BF, Chojnacki MR, Dixit K, Gururangan K, Horbinski C, Rosenow JM, Hsieh JK, Magill ST, Tate MC, Lukas RV  et al.  Surgical Treatment of Brain Tumor-Related Epilepsy: Current and Emerging Strategies.  Cancers (Basel)  2025 Nov 01;17(21). pii:3539
  9. Hu W, Zhao C, Zheng W, Lin Y, Luo N, Liu H, Wang X, Qi X, Wang X, Li XN  et al.  Use of integrated spatial transcriptomics and histopathological analysis in adamantinomatous craniopharyngiomas to identify stromal cells as a new cellular source of leukemia inhibitory factor.  J Neurosurg  2025 Nov 01;143(5):1336-1349. doi:10.3171/2025.4.JNS243146
  10. Myneni S, Tang L, Akbari H, Mayne R, Kazemi F, Xiong R, Redmond KJ, Bilsky MH, Charest-Morin R, Tobert DG  et al.  The Spinal Chordoma Patient Reported Outcome Survey (spCPROS): a patient-centered, disease-specific tool for assessing quality of life in spinal chordoma patients.  J Neurooncol  2025 Nov;175(2):813-824. doi:10.1007/s11060-025-05181-z
  11. Corn BW, Paulus R, Gondi V, Mehta MP, Fogh S, Wefel JS, Videtic GM, Sun A, Yoon H, Heinzerling JH  et al.  "Hope" Drives Quality of Life in Patients With Brain Metastases, But, the "Hope Center" Remains Elusive: An Analysis of NRG-CC003.  Int J Radiat Oncol Biol Phys  2025 Nov 01;123(3):642-652. doi:10.1016/j.ijrobp.2025.06.3884
  12. Kamijo Y, Mächler P, Ness N, Vu CQ, Kusakizako T, Mannuthodikayil J, Ku Z, Boisvert M, Grebenik E, Miyazaki I  et al.  A red fluorescent genetically encoded biosensor for in vivo imaging of extracellular L-lactate dynamics.  Nat Commun  2025 Oct 29;16(1):9531. pii:9531
  13. Zannikou M, Duffy JT, Procissi D, Najem H, Levine RN, Thakur A, Hambardzumyan D, Lee-Chang C, Leoni L, Horbinski CM  et al.  Bi-specific T cell-engaging antibody triggers protective immune memory and glioma microenvironment remodeling in immune-competent preclinical models.  J Immunother Cancer  2025 Oct 28;13(10). pii:e011714
  14. Cherng HR, Sun K, Bentzen SM, Brown PD, Armstrong TS, Palmer JD, Gondi V, Mehta MP, Mishra MV  Redefining Neurocognitive Outcomes After Radiation for Brain Metastases: A Patient-Level Meta-Analysis of Recovery Following Initial Decline.  J Natl Cancer Inst  2025 Oct 22;. pii:djaf264
  15. Barnes A, Gaikwad HK, Siegel D, Angarita D, Nebbia M, Anchordoquy T, Bourne D, Stewart M, Yildirim A, Fierro Cota MM  et al.  Role of Serum Stability and Lipoprotein Interactions in Lipid Structure-Tumor Accumulation Relationship.  ACS Nano  2025 Oct 21;19(41):36435-36450. doi:10.1021/acsnano.5c10594
  16. Hou D, Wang S, Castro BA, Katz JL, Dapash M, Arrieta VA, Vazquez-Cervantes GI, Wan H, Billingham LK, Du R  et al.  Dual aVß8 Integrin and PD-1 Blockade Overcomes TGFβ-Mediated B-Cell Suppression to Enhance Anti-Tumor Immunity.  Neuro Oncol  2025 Oct 14;27(9):2355-2369. doi:10.1093/neuonc/noaf106
  17. Sears TK, McCord M, Wang W, Steffens A, McCortney K, Chaliparambil R, Sarkaria JN, Horbinski CM  Methylation-induced suppression of YAP/TAZ confers sensitivity to HDAC inhibitors in high grade IDH mutant gliomas.  JCI Insight  2025 Oct 09;. pii:e195385
  18. Li J, Ross JL, Hambardzumyan D, Brat DJ  Immunopathology of Glioblastoma.  Annu Rev Pathol  2025 Oct 08;. doi:10.1146/annurev-pathmechdis-042524-025950
  19. Liang K, Zhou W, Li X, Wu J, Li D, Xie Y, Wei X  Quantitative analysis and trends in the study of the effects of electromagnetic radiation on the nervous system from a bibliometric perspective.  Electromagn Biol Med  2025 Oct 03;:1-14. doi:10.1080/15368378.2025.2568667
  20. Lo SS, Halasz LM, Choi S, Kumthekar P, Wang TJC, Shu HK, Sloan AE, Olson JJ  Congress of Neurological Surgeons systematic review and evidence-based guidelines for the role of radiotherapy in the management of patients with diffuse low grade glioma in adults: update.  J Neurooncol  2025 Oct;175(1):21-33. doi:10.1007/s11060-025-05074-1
  21. Xia Y, Papali P, Al-Mistarehi AH, Ahmed AK, Hansen LJ, Meyer C, Gross J, Khan M, Winkle M, Bettegowda C  et al.  Long-term functional outcomes and their relationship to nerve root sacrifice after definitive surgery for sacrococcygeal chordoma.  J Neurosurg Spine  2025 Oct 01;43(4):481-488. doi:10.3171/2025.3.SPINE241408
  22. Ali H, Zhou N, Chen L, van Hijfte L, Tulaiha R, Karri V, Zhou Y, Habashy K, Arrieta VA, Kim KS  et al.  YBX1&YBX3 as novel targets to potentiate immune checkpoint blockade response in gliomas.  Neuro Oncol  2025 Sep 30;. pii:noaf227
  23. Mehta MP, Gondi V, Ahluwalia MS, Roberge D, Sio TTW, Trifiletti DM, Muanza T, Krpan AM, Zhu Z, Ramakrishna NR  et al.  Tumor Treating Fields (TTFields) therapy after stereotactic radiosurgery for brain metastases from non-small cell lung cancer: final results of the phase 3 METIS study.  Int J Radiat Oncol Biol Phys  2025 Sep 29;. pii:S0360-3016(25)06217-0
  24. Wainwright D, Lukas R, Zhai L, Lauing K, Kim M, Koch T, Penco-Campillo M, Bommi P, Dixit K, Kumthekar P  et al.  Newly diagnosed glioblastoma IDHwt patients treated with radiation, nivolumab, and BMS-986205.  Res Sq  2025 Sep 25;. pii:rs.3.rs-7567487
  25. Pour-Rashidi A, Zandpazandi S, Perronne L, Hill VB, Krumpelman C, Subedi K, Kelahan L, Borhani AA, Savas H, Avery R  et al.  Intracranial Metastases from Uterine Leiomyosarcoma: A Systematic Review and Case Illustration.  J Clin Med  2025 Sep 20;14(18). pii:6631
  26. Lassman AB, Polley MC, Iwamoto FM, Sloan AE, Wang TJC, Aldape KD, Wefel JS, Gondi V, Gutierrez AN, Manasawala MH  et al.  Dual Immune Check Point Blockade in MGMT-Unmethylated Newly Diagnosed Glioblastoma: NRG Oncology BN007, a Randomized Phase II/III Clinical Trial.  J Clin Oncol  2025 Sep 20;43(27):3032-3040. doi:10.1200/JCO-25-00618
  27. Khan F, Petrosyan E, Liu Y, Bahrami A, Taefi E, Geula C, Lesniak MS, Chen P  Microglial TBK1 Signaling Promotes Breast Cancer Brain Metastasis.  Cancer Res  2025 Sep 18;. doi:10.1158/0008-5472.CAN-25-1791
  28. Khalili BF, Dixit K, Kamson DO, Horbinski C, Przybyla DJ, Tate MC, Heimberger AB, Lukas RV, Templer JW  The excitatory milieu in glioma: Mechanisms and therapeutic avenues.  Neuro Oncol  2025 Sep 17;27(8):1932-1945. doi:10.1093/neuonc/noaf063
  29. Yu X, Song X, Tiek D, Wu R, Walker M, Horbinski C, Hu B, Cheng SY  Targeting PDGFRA-SHP2 signaling enhances radiotherapy in IDH1-mutant glioma.  Neuro Oncol  2025 Sep 17;27(8):2023-2034. doi:10.1093/neuonc/noaf086
  30. Weber-Levine C, Xia Y, Al-Mistarehi AH, Jiang K, Mendelson BZ, Antar A, Ksabi NL, Zaitoun KJ, Papali P, Neerumalla S  et al.  The Impact of Expansile Duraplasty After Resection of Intramedullary Astrocytomas.  Oper Neurosurg  2025 Sep 16;. doi:10.1227/ons.0000000000001762
  31. Núñez FJ, Banerjee K, Mujeeb AA, Mauser A, Tronrud CE, Zhu Z, Raghuram S, Sheth MR, Agudelo JAP, Zelaya J  et al.  Autophagy Upregulation in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma Uncovers a Novel Therapeutic Target.  Res Sq  2025 Sep 11;. pii:rs.3.rs-7483444
  32. Kotecha R, Akdemir EY, Kutuk T, Ilgın C, Ahluwalia MS, Bi WL, Blakeley J, Dixit KS, Dunn IF, Galanis E  et al.  Benchmarking the efficacy of salvage systemic therapies for recurrent meningioma: A RANO group systematic review and meta-analysis to guide clinical trial design.  Neuro Oncol  2025 Sep 08;27(7):1670-1685. doi:10.1093/neuonc/noaf009
  33. Gui C, Wang JZ, Patil V, Landry AP, Singh O, Castelo-Branco P, Tabori U, Aldape K, Behling F, Barnholtz-Sloan JS  et al.  Analysis of TERT association with clinical outcome in meningiomas: a multi-institutional cohort study.  Lancet Oncol  2025 Sep;26(9):1191-1203. doi:10.1016/S1470-2045(25)00267-0
  34. Groff KJ, Patel RV, Feng Y, Ghosh HS, Millares Chavez MA, O'Brien J, Chen WC, Nitturi V, Save AV, Youngblood MW  et al.  The effect of TERT promoter mutation on predicting meningioma outcomes: a multi-institutional cohort analysis.  Lancet Oncol  2025 Sep;26(9):1178-1190. doi:10.1016/S1470-2045(25)00422-X
  35. Nassiri F, Patil V, Yefet LS, Singh O, Liu J, Dang RMA, Yamaguchi TN, Daras M, Cloughesy TF, Colman H  et al.  Author Correction: Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial.  Nat Med  2025 Sep;31(9):3204. doi:10.1038/s41591-025-03895-1
  36. Beck JA, Mazcko C, Belluco S, Bitar M, Brat D, Bush JW, Chkheidze R, Corps KN, Frank C, Giannini C  et al.  Comparative pathology boards facilitate the translation of knowledge between canine and human cancer patients.  Brain Pathol  2025 Sep;35(5):e70013. pii:e70013
  37. Benato A, Texakalidis P, Wolinsky JP  Reconstruction of posterior elements of the spine with femoral shaft allograft after spondylectomy for En bloc resection of tumor.  Eur Spine J  2025 Aug 14;. doi:10.1007/s00586-025-09141-z
  38. Feng Y, Haupt B, Huynh TT, Meshaw R, Martin-Regalado A, Thakur A, Duffy JT, Alzeer A, Siegel DA, Barnes A  et al.  Longitudinal Imaging Reveals Tumor Uptake and Prolonged Retention of Bispecific T Cell-Engaging Antibody in GBM via Passive and Active Mechanisms.  Clin Cancer Res  2025 Aug 14;31(16):3537-3549. doi:10.1158/1078-0432.CCR-24-4194
  39. Habashy KJ, Synold TW, Feng Y, Gomez C, Amidei C, Ward R, VanderMolen S, Zarrieneh A, Kim KS, Gomez M  et al.  Pharmacokinetic Analysis of Carboplatin and Fluorescein Brain Retention following Ultrasound-Based Blood-Brain Barrier Opening.  Clin Cancer Res  2025 Aug 14;31(16):3562-3570. doi:10.1158/1078-0432.CCR-25-0080
  40. Wen PY, Weller M, Lee EQ, Touat M, Khasraw M, Rahman R, Platten M, Lim M, Winkler F, Horbinski C  et al.  Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions.  Neuro Oncol  2025 Aug 13;. pii:noaf177
  41. Rock V, Ahluwalia MS, Anthony M, Arons D, Arzbaecher J, Dunbar E, Fraher C, Freund M, Gondi V, Khanuja S  et al.  Guiding principles for adult CNS tumor treatment programs.  Neurooncol Adv  2025;7(1):vdaf169. pii:vdaf169
  42. Liang J, Sun W, Zhou Y, Zhang P, Chen Y, Li X, He H, Liu X, Zhou S, Shen J  et al.  Study on the Central Neural Pathways Connecting the Brain and Peripheral Acupoints Using Neural Tracers.  CNS Neurosci Ther  2025 Aug;31(8):e70554. pii:e70554
  43. Tan PH, Ellis IO, Allison KH, Badve SS, Brogi E, Callagy G, Charafe-Jauffret E, Chen CJ, Chen YY, Collins LC  et al.  Malignant phyllodes tumours of the breast: the case for revising WHO's 'full house' diagnostic criteria.  Histopathology  2025 Aug;87(2):169-182. doi:10.1111/his.15455
  44. Smith HL, Duckett DJ, Mejia-Bautista M, Alshawa A, Jamshidi P, Castellani RJ, Lukas RV, Chandler JP, Jennings LJ, Santana-Santos L  et al.  IDH-wildtype astrocytoma with FH mutation, epigenetic similarity to IDH-mutant astrocytoma, and hypermethylation of CDKN2A arising in the brainstem.  J Neuropathol Exp Neurol  2025 Jul 22;. pii:nlaf086
  45. Izhar M, Al Gharyani M, Kattaa AH, Cardona JJ, Jain RP, Shaghaghian E, Hori YS, Lam FC, Abu Reesh D, Emrich SC  et al.  Overview of Preclinical and Clinical Trials of Nanoparticles for the Treatment of Brain Metastases.  Pharmaceutics  2025 Jul 11;17(7). pii:899
  46. Liu Y, Pang L, Khan F, Wu J, Zhou F, Horbinski C, Bao S, Yu JS, Lathia JD, Chen P  Glycoprotein NMB mediates bidirectional GSC-TAM interactions to promote tumor progression.  JCI Insight  2025 Jul 08;10(13). pii:e187684
  47. Vormittag-Nocito E, Duckett D, Castellani RJ, Ahrendsen JT, Lu X, Jennings LJ, Lukas RV, Magill ST, Santana-Santos L, Brat DJ  et al.  Meningiomas With Chromosomal Polysomies Reveal Nonrandom Gain of Chromosomes, Distinct Methylation Signature, and Lower Risk of Recurrence.  Mod Pathol  2025 Jul;38(7):100775. doi:10.1016/j.modpat.2025.100775
  48. Cheok SK, Ruzevick J, Briggs RG, Cote DJ, Shah I, Gomez D, Bove I, Feng JJ, Pangal DJ, Strickland BA  et al.  A contemporary, multiinstitutional analysis of transcription factor lineage in pituitary adenomas: comparative study of neuroimaging, histopathology, and clinical outcomes.  J Neurosurg  2025 Jul 01;143(1):146-154. doi:10.3171/2024.10.JNS24853
  49. Fernandopulle MS, Cotty-Fattal Z, Smith H, Mejia Bautista M, Ahrendsen JT, Jennings LJ, Santana-Santos L, Sukhanova M, Conway K, Primdahl D  et al.  Dual TERT promoter mutations in an oligodendroglioma, IDH-mutant, 1p/19q co-deleted.  J Neuropathol Exp Neurol  2025 Jul 01;84(7):658-660. doi:10.1093/jnen/nlae138
  50. Cheng SY, Yu X, Song X, Schäfer R, Meng Q, Tiek D, Wu R, He Q, Walker M, Yang R  et al.  An EGFR Co-Amplified and De Novo Long Noncoding RNA HELDR Promotes Glioblastoma Malignancy through KAT7-Driven Gene Programs.  Res Sq  2025 Jun 24;. pii:rs.3.rs-6456987
These are the publications from our team members that have been most recently indexed by PubMed. Visit PubMed to see more of our publications.

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