Recent Publications
Browse recent studies from the Lou and Jean Malnati Brain Tumor Institute to learn more about our cutting-edge research.
- He Z, Li W, Liu T, Li X, Han J, Zhang T, Yuan Y GAGM: Geometry-aware graph matching framework for weakly supervised gyral hinge correspondence. Med Image Anal 2026 Jan;107(Pt A):103820. doi:10.1016/j.media.2025.103820
- Sadagopan NS, Gomez M, Tripathi S, Billingham LK, DeLay SL, Cady MA, Congivaram HTS, Chia TY, Wan H, Wang S et al. NOTCH3 drives fatty acid oxidation and ferroptosis resistance in aggressive meningiomas. J Neurooncol 2025 Dec;175(3):979-991. doi:10.1007/s11060-025-05208-5
- Myneni S, Tang L, Akbari H, Mayne R, Kazemi F, Xiong R, Redmond KJ, Bilsky MH, Charest-Morin R, Tobert DG et al. The Spinal Chordoma Patient Reported Outcome Survey (spCPROS): a patient-centered, disease-specific tool for assessing quality of life in spinal chordoma patients. J Neurooncol 2025 Nov;175(2):813-824. doi:10.1007/s11060-025-05181-z
- Corn BW, Paulus R, Gondi V, Mehta MP, Fogh S, Wefel JS, Videtic GM, Sun A, Yoon H, Heinzerling JH et al. "Hope" Drives Quality of Life in Patients With Brain Metastases, But, the "Hope Center" Remains Elusive: An Analysis of NRG-CC003. Int J Radiat Oncol Biol Phys 2025 Nov 01;123(3):642-652. doi:10.1016/j.ijrobp.2025.06.3884
- Cherng HR, Sun K, Bentzen SM, Brown PD, Armstrong TS, Palmer JD, Gondi V, Mehta MP, Mishra MV Redefining Neurocognitive Outcomes After Radiation for Brain Metastases: A Patient-Level Meta-Analysis of Recovery Following Initial Decline. J Natl Cancer Inst 2025 Oct 22;. pii:djaf264
- Barnes A, Gaikwad HK, Siegel D, Angarita D, Nebbia M, Anchordoquy T, Bourne D, Stewart M, Yildirim A, Fierro Cota MM et al. Role of Serum Stability and Lipoprotein Interactions in Lipid Structure-Tumor Accumulation Relationship. ACS Nano 2025 Oct 21;19(41):36435-36450. doi:10.1021/acsnano.5c10594
- Hou D, Wang S, Castro BA, Katz JL, Dapash M, Arrieta VA, Vazquez-Cervantes GI, Wan H, Billingham LK, Du R et al. Dual aVß8 Integrin and PD-1 Blockade Overcomes TGFβ-Mediated B-Cell Suppression to Enhance Anti-Tumor Immunity. Neuro Oncol 2025 Oct 14;27(9):2355-2369. doi:10.1093/neuonc/noaf106
- Sears TK, McCord M, Wang W, Steffens A, McCortney K, Chaliparambil R, Sarkaria JN, Horbinski CM Methylation-induced suppression of YAP/TAZ confers sensitivity to HDAC inhibitors in high grade IDH mutant gliomas. JCI Insight 2025 Oct 09;. pii:e195385
- Li J, Ross JL, Hambardzumyan D, Brat DJ Immunopathology of Glioblastoma. Annu Rev Pathol 2025 Oct 08;. doi:10.1146/annurev-pathmechdis-042524-025950
- Liang K, Zhou W, Li X, Wu J, Li D, Xie Y, Wei X Quantitative analysis and trends in the study of the effects of electromagnetic radiation on the nervous system from a bibliometric perspective. Electromagn Biol Med 2025 Oct 03;:1-14. doi:10.1080/15368378.2025.2568667
- Lo SS, Halasz LM, Choi S, Kumthekar P, Wang TJC, Shu HK, Sloan AE, Olson JJ Congress of Neurological Surgeons systematic review and evidence-based guidelines for the role of radiotherapy in the management of patients with diffuse low grade glioma in adults: update. J Neurooncol 2025 Oct;175(1):21-33. doi:10.1007/s11060-025-05074-1
- Xia Y, Papali P, Al-Mistarehi AH, Ahmed AK, Hansen LJ, Meyer C, Gross J, Khan M, Winkle M, Bettegowda C et al. Long-term functional outcomes and their relationship to nerve root sacrifice after definitive surgery for sacrococcygeal chordoma. J Neurosurg Spine 2025 Oct 01;43(4):481-488. doi:10.3171/2025.3.SPINE241408
- Ali H, Zhou N, Chen L, van Hijfte L, Tulaiha R, Karri V, Zhou Y, Habashy K, Arrieta VA, Kim KS et al. YBX1&YBX3 as novel targets to potentiate immune checkpoint blockade response in gliomas. Neuro Oncol 2025 Sep 30;. pii:noaf227
- Mehta MP, Gondi V, Ahluwalia MS, Roberge D, Sio TTW, Trifiletti DM, Muanza T, Krpan AM, Zhu Z, Ramakrishna NR et al. Tumor Treating Fields (TTFields) therapy after stereotactic radiosurgery for brain metastases from non-small cell lung cancer: final results of the phase 3 METIS study. Int J Radiat Oncol Biol Phys 2025 Sep 29;. pii:S0360-3016(25)06217-0
- Wainwright D, Lukas R, Zhai L, Lauing K, Kim M, Koch T, Penco-Campillo M, Bommi P, Dixit K, Kumthekar P et al. Newly diagnosed glioblastoma IDHwt patients treated with radiation, nivolumab, and BMS-986205. Res Sq 2025 Sep 25;. pii:rs.3.rs-7567487
- Pour-Rashidi A, Zandpazandi S, Perronne L, Hill VB, Krumpelman C, Subedi K, Kelahan L, Borhani AA, Savas H, Avery R et al. Intracranial Metastases from Uterine Leiomyosarcoma: A Systematic Review and Case Illustration. J Clin Med 2025 Sep 20;14(18). pii:6631
- Lassman AB, Polley MC, Iwamoto FM, Sloan AE, Wang TJC, Aldape KD, Wefel JS, Gondi V, Gutierrez AN, Manasawala MH et al. Dual Immune Check Point Blockade in MGMT-Unmethylated Newly Diagnosed Glioblastoma: NRG Oncology BN007, a Randomized Phase II/III Clinical Trial. J Clin Oncol 2025 Sep 20;43(27):3032-3040. doi:10.1200/JCO-25-00618
- Khan F, Petrosyan E, Liu Y, Bahrami A, Taefi E, Geula C, Lesniak MS, Chen P Microglial TBK1 Signaling Promotes Breast Cancer Brain Metastasis. Cancer Res 2025 Sep 18;. doi:10.1158/0008-5472.CAN-25-1791
- Khalili BF, Dixit K, Kamson DO, Horbinski C, Przybyla DJ, Tate MC, Heimberger AB, Lukas RV, Templer JW The excitatory milieu in glioma: Mechanisms and therapeutic avenues. Neuro Oncol 2025 Sep 17;27(8):1932-1945. doi:10.1093/neuonc/noaf063
- Yu X, Song X, Tiek D, Wu R, Walker M, Horbinski C, Hu B, Cheng SY Targeting PDGFRA-SHP2 signaling enhances radiotherapy in IDH1-mutant glioma. Neuro Oncol 2025 Sep 17;27(8):2023-2034. doi:10.1093/neuonc/noaf086
- Weber-Levine C, Xia Y, Al-Mistarehi AH, Jiang K, Mendelson BZ, Antar A, Ksabi NL, Zaitoun KJ, Papali P, Neerumalla S et al. The Impact of Expansile Duraplasty After Resection of Intramedullary Astrocytomas. Oper Neurosurg 2025 Sep 16;. doi:10.1227/ons.0000000000001762
- Núñez FJ, Banerjee K, Mujeeb AA, Mauser A, Tronrud CE, Zhu Z, Raghuram S, Sheth MR, Agudelo JAP, Zelaya J et al. Autophagy Upregulation in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma Uncovers a Novel Therapeutic Target. Res Sq 2025 Sep 11;. pii:rs.3.rs-7483444
- Kotecha R, Akdemir EY, Kutuk T, Ilgın C, Ahluwalia MS, Bi WL, Blakeley J, Dixit KS, Dunn IF, Galanis E et al. Benchmarking the efficacy of salvage systemic therapies for recurrent meningioma: A RANO group systematic review and meta-analysis to guide clinical trial design. Neuro Oncol 2025 Sep 08;27(7):1670-1685. doi:10.1093/neuonc/noaf009
- Gui C, Wang JZ, Patil V, Landry AP, Singh O, Castelo-Branco P, Tabori U, Aldape K, Behling F, Barnholtz-Sloan JS et al. Analysis of TERT association with clinical outcome in meningiomas: a multi-institutional cohort study. Lancet Oncol 2025 Sep;26(9):1191-1203. doi:10.1016/S1470-2045(25)00267-0
- Groff KJ, Patel RV, Feng Y, Ghosh HS, Millares Chavez MA, O'Brien J, Chen WC, Nitturi V, Save AV, Youngblood MW et al. The effect of TERT promoter mutation on predicting meningioma outcomes: a multi-institutional cohort analysis. Lancet Oncol 2025 Sep;26(9):1178-1190. doi:10.1016/S1470-2045(25)00422-X
- Nassiri F, Patil V, Yefet LS, Singh O, Liu J, Dang RMA, Yamaguchi TN, Daras M, Cloughesy TF, Colman H et al. Author Correction: Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial. Nat Med 2025 Sep;31(9):3204. doi:10.1038/s41591-025-03895-1
- Beck JA, Mazcko C, Belluco S, Bitar M, Brat D, Bush JW, Chkheidze R, Corps KN, Frank C, Giannini C et al. Comparative pathology boards facilitate the translation of knowledge between canine and human cancer patients. Brain Pathol 2025 Sep;35(5):e70013. pii:e70013
- Benato A, Texakalidis P, Wolinsky JP Reconstruction of posterior elements of the spine with femoral shaft allograft after spondylectomy for En bloc resection of tumor. Eur Spine J 2025 Aug 14;. doi:10.1007/s00586-025-09141-z
- Feng Y, Haupt B, Huynh TT, Meshaw R, Martin-Regalado A, Thakur A, Duffy JT, Alzeer A, Siegel DA, Barnes A et al. Longitudinal Imaging Reveals Tumor Uptake and Prolonged Retention of Bispecific T Cell-Engaging Antibody in GBM via Passive and Active Mechanisms. Clin Cancer Res 2025 Aug 14;31(16):3537-3549. doi:10.1158/1078-0432.CCR-24-4194
- Habashy KJ, Synold TW, Feng Y, Gomez C, Amidei C, Ward R, VanderMolen S, Zarrieneh A, Kim KS, Gomez M et al. Pharmacokinetic Analysis of Carboplatin and Fluorescein Brain Retention following Ultrasound-Based Blood-Brain Barrier Opening. Clin Cancer Res 2025 Aug 14;31(16):3562-3570. doi:10.1158/1078-0432.CCR-25-0080
- Wen PY, Weller M, Lee EQ, Touat M, Khasraw M, Rahman R, Platten M, Lim M, Winkler F, Horbinski C et al. Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions. Neuro Oncol 2025 Aug 13;. pii:noaf177
- Gondi V, Pugh SL, Mehta MP, Wefel JS, Tomé WA, Sun AY, Grecula J, Redmond KJ, Fogh S, Gaspar L et al. Hippocampal Avoidance During Prophylactic Cranial Irradiation for Patients With Small Cell Lung Cancer: Randomized Phase II/III Trial NRG-CC003. J Clin Oncol 2025 Aug 11;:JCO2500221. doi:10.1200/JCO-25-00221
- Rock V, Ahluwalia MS, Anthony M, Arons D, Arzbaecher J, Dunbar E, Fraher C, Freund M, Gondi V, Khanuja S et al. Guiding principles for adult CNS tumor treatment programs. Neurooncol Adv 2025;7(1):vdaf169. pii:vdaf169
- Liang J, Sun W, Zhou Y, Zhang P, Chen Y, Li X, He H, Liu X, Zhou S, Shen J et al. Study on the Central Neural Pathways Connecting the Brain and Peripheral Acupoints Using Neural Tracers. CNS Neurosci Ther 2025 Aug;31(8):e70554. pii:e70554
- Hu W, Zhao C, Zheng W, Lin Y, Luo N, Liu H, Wang X, Qi X, Wang X, Li XN et al. Use of integrated spatial transcriptomics and histopathological analysis in adamantinomatous craniopharyngiomas to identify stromal cells as a new cellular source of leukemia inhibitory factor. J Neurosurg 2025 Aug 01;:1-14. doi:10.3171/2025.4.JNS243146
- Tan PH, Ellis IO, Allison KH, Badve SS, Brogi E, Callagy G, Charafe-Jauffret E, Chen CJ, Chen YY, Collins LC et al. Malignant phyllodes tumours of the breast: the case for revising WHO's 'full house' diagnostic criteria. Histopathology 2025 Aug;87(2):169-182. doi:10.1111/his.15455
- Smith HL, Duckett DJ, Mejia-Bautista M, Alshawa A, Jamshidi P, Castellani RJ, Lukas RV, Chandler JP, Jennings LJ, Santana-Santos L et al. IDH-wildtype astrocytoma with FH mutation, epigenetic similarity to IDH-mutant astrocytoma, and hypermethylation of CDKN2A arising in the brainstem. J Neuropathol Exp Neurol 2025 Jul 22;. pii:nlaf086
- Izhar M, Al Gharyani M, Kattaa AH, Cardona JJ, Jain RP, Shaghaghian E, Hori YS, Lam FC, Abu Reesh D, Emrich SC et al. Overview of Preclinical and Clinical Trials of Nanoparticles for the Treatment of Brain Metastases. Pharmaceutics 2025 Jul 11;17(7). pii:899
- Liu Y, Pang L, Khan F, Wu J, Zhou F, Horbinski C, Bao S, Yu JS, Lathia JD, Chen P Glycoprotein NMB mediates bidirectional GSC-TAM interactions to promote tumor progression. JCI Insight 2025 Jul 08;10(13). pii:e187684
- Vormittag-Nocito E, Duckett D, Castellani RJ, Ahrendsen JT, Lu X, Jennings LJ, Lukas RV, Magill ST, Santana-Santos L, Brat DJ et al. Meningiomas With Chromosomal Polysomies Reveal Nonrandom Gain of Chromosomes, Distinct Methylation Signature, and Lower Risk of Recurrence. Mod Pathol 2025 Jul;38(7):100775. doi:10.1016/j.modpat.2025.100775
- Cheok SK, Ruzevick J, Briggs RG, Cote DJ, Shah I, Gomez D, Bove I, Feng JJ, Pangal DJ, Strickland BA et al. A contemporary, multiinstitutional analysis of transcription factor lineage in pituitary adenomas: comparative study of neuroimaging, histopathology, and clinical outcomes. J Neurosurg 2025 Jul 01;143(1):146-154. doi:10.3171/2024.10.JNS24853
- Fernandopulle MS, Cotty-Fattal Z, Smith H, Mejia Bautista M, Ahrendsen JT, Jennings LJ, Santana-Santos L, Sukhanova M, Conway K, Primdahl D et al. Dual TERT promoter mutations in an oligodendroglioma, IDH-mutant, 1p/19q co-deleted. J Neuropathol Exp Neurol 2025 Jul 01;84(7):658-660. doi:10.1093/jnen/nlae138
- Cheng SY, Yu X, Song X, Schäfer R, Meng Q, Tiek D, Wu R, He Q, Walker M, Yang R et al. An EGFR Co-Amplified and De Novo Long Noncoding RNA HELDR Promotes Glioblastoma Malignancy through KAT7-Driven Gene Programs. Res Sq 2025 Jun 24;. pii:rs.3.rs-6456987
- Al-Mistarehi AH, Zaitoun KJ, Javed S, Xia Y, Hersh A, Ghaith AK, Weber-Levine C, Jiang K, Khan M, Mendelson B et al. Survival and Functional Outcomes Following Surgical Resection of Intramedullary Spinal Cord Tumors: A Series of 253 Patients over 22 Years. Cancers (Basel) 2025 Jun 24;17(13). pii:2112
- Forrest N, Guggilla V, Bell A, Zelisko S, Federico EM, Power EA, Birch S, Nandoliya KR, Houskamp EJ, Tran S et al. Natural language processing algorithms identify wild-type isocitrate dehydrogenase gliomas in electronic health records. Neurooncol Adv 2025;7(1):vdaf111. pii:vdaf111
- Sadagopan NS, Gomez M, Tripathi S, Billingham LK, DeLay SL, Cady MA, Congivaram HTS, Chia TY, Wan H, Wang S et al. NOTCH3 Drives Fatty Acid Oxidation and Ferroptosis Resistance in Aggressive Meningiomas. Res Sq 2025 Jun 04;. pii:rs.3.rs-6779386
- Sperduto PW, Marqueen KE, Chang E, Li J, Davies MA, Ebner DK, Breen WG, Lamba N, Shih HA, Edwards D et al. Improved Survival and Prognostication in Melanoma Patients With Brain Metastases: An Update of the Melanoma Graded Prognostic Assessment. J Clin Oncol 2025 Jun;43(16):1910-1919. doi:10.1200/JCO-24-01351
- Gruchala T, Lewis CW, Abplanalp K, Jayabalan P, Walunas TL, Johnson JL, Wainwright DA, Lukas RV, Spill G, Roy I Predicting medical prognosis in patients with glioblastoma during inpatient rehabilitation using bed mobility function. PM R 2025 May 19;. doi:10.1002/pmrj.13402
- Turunen JR, Kumthekar P, Ahmed AU Beyond the brain: exploring the impact of animal models of leptomeningeal disease from solid tumors. Acta Neuropathol Commun 2025 May 19;13(1):103. pii:103
- Izhar M, Lesniak MS Role of Extracellular Vesicles in the Pathogenesis of Brain Metastasis. J Extracell Biol 2025 May;4(5):e70051. pii:e70051
These are the publications from our team members that have been most recently indexed by PubMed. Visit PubMed to see more of our publications.