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Recent Publications

Browse recent studies from the Lou and Jean Malnati Brain Tumor Institute to learn more about our cutting-edge research.

  1. Schubert MC, Soyka SJ, Tamimi A, Maus E, Schroers J, Wißmann N, Reyhan E, Tetzlaff SK, Yang Y, Denninger R  et al.  Deep intravital brain tumor imaging enabled by tailored three-photon microscopy and analysis.  Nat Commun  2024 Sep 10;15(1):7383. pii:7383
  2. Nandoliya KR, Congivaram H, Youngblood MW, Chen WC, Chaliparambil RK, Horbinski CM, Choudhury A, Brat DJ, Chandler JP, Magill ST  et al.  Clinical and methylomic features of spinal meningiomas.  J Neurooncol  2024 Sep 10;. doi:10.1007/s11060-024-04736-w
  3. Schwartz C, Ueberschaer MF, Rautalin I, Grauvogel J, Bissolo M, Masalha W, Steiert C, Schnell O, Beck J, Ebel F  et al.  Frailty indices predict mortality, complications and functional improvements in supratentorial meningioma patients over 80 years of age.  J Neurooncol  2024 Sep 04;. doi:10.1007/s11060-024-04780-6
  4. Zhang X, Duan S, Apostolou PE, Wu X, Watanabe J, Gallitto M, Barron T, Taylor KR, Woo PJ, Hua X  et al.  CHD2 Regulates Neuron-Glioma Interactions in Pediatric Glioma.  Cancer Discov  2024 Sep 04;14(9):1732-1754. doi:10.1158/2159-8290.CD-23-0012
  5. Giordano A, Kumthekar PU, Jin Q, Binboga Kurt B, Ren S, Li T, Leone JP, Mittendorf EA, Pereslete AM, Sharp L  et al.  A phase II study of atezolizumab, pertuzumab, and high-dose trastuzumab for central nervous system metastases in patients with HER2-positive breast cancer.  Clin Cancer Res  2024 Sep 03;. doi:10.1158/1078-0432.CCR-24-1161
  6. Panek WK, Toedebusch RG, Mclaughlin BE, Dickinson PJ, Van Dyke JE, Woolard KD, Berens ME, Lesniak MS, Sturges BK, Vernau KM  et al.  The CCL2-CCR4 axis promotes Regulatory T cell trafficking to canine glioma tissues.  J Neurooncol  2024 Sep;169(3):647-658. doi:10.1007/s11060-024-04766-4
  7. Li X, Nguyen TTA, Zhang J, Nayak A, Liu Y, Duckworth LA, Zhang G, Bakkar R, Agarwal I, Hou Y  et al.  Validation Study of the Newly Proposed Refined Diagnostic Criteria for Malignant Phyllodes Tumor With 136 Borderline and Malignant Phyllodes Tumor Cases.  Am J Surg Pathol  2024 Sep 01;48(9):1146-1153. doi:10.1097/PAS.0000000000002264
  8. Sahm F, Aldape KD, Brastianos PK, Brat DJ, Dahiya S, von Deimling A, Giannini C, Gilbert MR, Louis DN, Raleigh DR  et al.  cIMPACT-NOW Update 8: Clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas.  Neuro Oncol  2024 Aug 30;. pii:noae170
  9. Le Rhun E, Nayak L, Lim-Fat MJ, Rudà R, Pentsova E, Forsyth P, O'Brien BJ, Preusser M, Kumthekar P, Brandsma D  et al.  NANO-LM: An updated scorecard for the clinical assessment of patients with leptomeningeal metastases.  Neuro Oncol  2024 Aug 29;. pii:noae171
  10. Wang S, Castro BA, Katz JL, Arrieta VA, Najem H, Vazquez-Cervantes GI, Wan H, Olson IE, Hou D, Dapash M  et al.  B cell-based therapy produces antibodies that inhibit glioblastoma growth.  J Clin Invest  2024 Aug 29;. pii:e177384
  11. An S, McCortney K, Walshon J, Leonard K, Wray B, McCord M, DeCuypere M, Horbinski C  Methylation profiling of plasma cell-free DNA in pediatric brain tumor patients.  Acta Neuropathol  2024 Aug 26;148(1):29. doi:10.1007/s00401-024-02795-x
  12. Wang JZ, Patil V, Landry AP, Gui C, Ajisebutu A, Liu J, Saarela O, Pugh SL, Won M, Patel Z  et al.  Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma.  Nat Med  2024 Aug 21;. doi:10.1038/s41591-024-03167-4
  13. Tripathi S, Najem H, Dussold C, Pacheco S, Du R, Sooreshjani M, Hurley LA, Chandler JP, Stupp R, Sonabend AM  et al.  Pediatric glioma immune profiling identifies TIM3 as a therapeutic target in BRAF-Fusion pilocytic astrocytoma.  J Clin Invest  2024 Aug 13;. pii:e177413
  14. Morshed RA, Nguyen MP, Youngblood MW, Perlow HK, Lucas CG, Patel AJ, Palmer JD, Chandler JP, Theodosopoulos PV, Magill ST  et al.  Gene Expression Changes Associated With Recurrence After Gross Total Resection of Newly Diagnosed World Health Organization Grade 1 Meningioma.  Neurosurgery  2024 Aug 05;. doi:10.1227/neu.0000000000003133
  15. Xia Y, Papali P, Al-Mistarehi AH, Hansen LJ, Azad TD, Ahmed AK, Meyer C, Gross J, Khan M, Bettegowda C  et al.  Outcomes After Definitive Surgery for Spinal and Sacral Chordoma in 101 Patients Over 20 Years.  Neurosurgery  2024 Aug 05;. doi:10.1227/neu.0000000000003130
  16. Budhiraja S, McManus G, Baisiwala S, Perrault EN, Cho S, Saathoff M, Chen L, Park CH, Kazi HA, Dmello C  et al.  ARF4-mediated retrograde trafficking as a driver of chemoresistance in glioblastoma.  Neuro Oncol  2024 Aug 05;26(8):1421-1437. doi:10.1093/neuonc/noae059
  17. Leclair NK, Choudury A, Chen WC, Magill ST, McCortney K, Horbinski CM, Chen Z, Goldschmidt E, Eaton CD, Bulsara KR  et al.  RNA splicing as a biomarker and phenotypic driver of meningioma DNA methylation groups.  Neuro Oncol  2024 Aug 02;. pii:noae150
  18. Mrugala MM, Shi W, Iwomoto F, Lukas RV, Palmer JD, Suh JH, Glas M  Global post‑marketing safety surveillance of Tumor Treating Fields (TTFields) therapy in over 25,000 patients with CNS malignancies treated between 2011-2022.  J Neurooncol  2024 Aug;169(1):25-38. doi:10.1007/s11060-024-04682-7
  19. Yang Y, Wadhwani N, Shimomura A, Zheng S, Chandler J, Lesniak MS, Tate MC, Sonabend AM, Kalapurakal J, Horbinski C  et al.  Long-term outcomes of central neurocytoma - an institutional experience.  J Neurooncol  2024 Aug;169(1):195-201. doi:10.1007/s11060-024-04713-3
  20. Xu C, Chen G, Yu B, Sun B, Zhang Y, Zhang M, Yang Y, Xiao Y, Cheng SY, Li Y  et al.  TRIM24 Cooperates with Ras Mutation to Drive Glioma Progression through snoRNA Recruitment of PHAX and DNA-PKcs.  Adv Sci (Weinh)  2024 Aug;11(29):e2400023. pii:2400023
  21. Raleigh DR, Chen WC, Gondi V, Rogers L, Mehta M  Implications and interchangeability of meningioma biomarkers for clinical trials and clinical practice.  J Neurooncol  2024 Aug;169(1):215-217. doi:10.1007/s11060-024-04700-8
  22. Smith H, Jean J, Duckett D, Vormittag-Nocito E, Nezami BG, Jennings LJ, Ahrendsen JT, Yang XJ, Primdahl D, Conway K  et al.  Diagnostic utility of multimodal advanced molecular testing to classify metastases of unknown primaries: A case of a patient with no known medical history.  J Neuropathol Exp Neurol  2024 Jul 31;. pii:nlae086
  23. Kim KS, Habashy K, Gould A, Zhao J, Najem H, Amidei C, Saganty R, Arrieta VA, Dmello C, Chen L  et al.  Fc-enhanced anti-CTLA-4, anti-PD-1, doxorubicin, and ultrasound-mediated BBB opening: A novel combinatorial immunotherapy regimen for gliomas.  Neuro Oncol  2024 Jul 19;. pii:noae135
  24. Nandoliya KR, Vignolles-Jeong J, Karras CL, Govind S, Finger G, Thirunavu V, Sonabend AM, Magill ST, Prevedello DM, Chandler JP  Clinical characteristics and outcomes after trigeminal schwannoma resection: a multi-institutional experience.  Neurosurg Rev  2024 Jul 18;47(1):340. doi:10.1007/s10143-024-02550-6
  25. Thirunavu V, Drumm M, McCord M, Steffens A, Youngblood MW, Nandoliya KR, Smith H, Walshon J, McCortney K, Magill ST  et al.  Optimizing the use of Ki-67 proliferative index as a prognostic biomarker in meningiomas using digital analysis.  J Neurosurg  2024 Jul 05;:1-11. doi:10.3171/2024.4.JNS232857
  26. Kostelecky N, Wadhwani N, Golubovich I, Vormittag-Nocito E, Gao J, Jennings L, Caron M, Jamshidi P, Ahrendsen JT, Castellani R  et al.  Transdifferentiation of metastatic melanoma into cerebellar angiosarcoma.  J Neuropathol Exp Neurol  2024 Jul 04;. pii:nlae075
  27. Liggett MR, Lashley S, Gill NP, Scholtens DM, Dawood ZS, Alam HB  Plasma therapy for traumatic brain injury: Rationale for a prospective randomized trial.  Transfusion  2024 Jul;64(7):1362-1371. doi:10.1111/trf.17928
  28. Lyons CE, Dixit K  Elsberg Syndrome: A Case Report of a Novel Radiographic Presentation.  Neurohospitalist  2024 Jul;14(3):347-350. doi:10.1177/19418744241241107
  29. Qi L, Du Y, Huang Y, Kogiso M, Zhang H, Xiao S, Abdallah A, Suarez M, Niu L, Liu ZG  et al.  CD57 defines a novel cancer stem cell that drive invasion of diffuse pediatric-type high grade gliomas.  Br J Cancer  2024 Jul;131(2):258-270. doi:10.1038/s41416-024-02724-5
  30. Rudà R, Horbinski C, van den Bent M, Preusser M, Soffietti R  IDH inhibition in gliomas: from preclinical models to clinical trials.  Nat Rev Neurol  2024 Jul;20(7):395-407. doi:10.1038/s41582-024-00967-7
  31. Huang ZL, Liu ZG, Lin Q, Tao YL, Li X, Baxter P, Su JM, Adesina AM, Man C, Chintagumpala M  et al.  Fractionated radiation therapy alters energy metabolism and induces cellular quiescence exit in patient-derived orthotopic xenograft models of high-grade glioma.  Transl Oncol  2024 Jul;45:101988. pii:101988
  32. Rabin EE, Huang J, Kim M, Mozny A, Lauing KL, Penco-Campillo M, Zhai L, Bommi P, Mi X, Power EA  et al.  Age-stratified comorbid and pharmacologic analysis of patients with glioblastoma.  Brain Behav Immun Health  2024 Jul;38:100753. pii:100753
  33. Benedetti DJ, Renfro LA, Tfirn I, Daw NC, Kalapurakal JA, Ehrlich PF, Khanna G, Perlman E, Warwick A, Gow KW  et al.  Treatment and outcomes of clear cell sarcoma of the kidney: A report from the Children's Oncology Group studies AREN0321 and AREN03B2.  Cancer  2024 Jul 01;130(13):2361-2371. doi:10.1002/cncr.35266
  34. van den Bent MJ, French PJ, Brat D, Tonn JC, Touat M, Ellingson BM, Young RJ, Pallud J, von Deimling A, Sahm F  et al.  The biological significance of tumor grade, age, enhancement and extent of resection in IDH mutant gliomas: how should they inform treatment decision in the era of IDH inhibitors? Invited review.  Neuro Oncol  2024 Jun 24;. pii:noae107
  35. Wilcox JA, Chukwueke UN, Ahn MJ, Aizer AA, Bale TA, Brandsma D, Brastianos PK, Chang S, Daras M, Forsyth P  et al.  Leptomeningeal metastases from solid tumors: A SNO and ASCO consensus review on clinical management and future directions.  Neuro Oncol  2024 Jun 21;. pii:noae103
  36. Panek WK, Toedebusch RG, Mclaughlin BE, Dickinson PJ, Dyke JE, Woolard KD, Berens ME, Lesniak MS, Sturges BK, Vernau KM  et al.  The CCL2-CCR4 Axis Promotes Regulatory T Cell Trafficking to Canine Glioma Tissues.  Res Sq  2024 Jun 17;. pii:rs.3.rs-4474288
  37. Najem H, Lea ST, Tripathi S, Hurley L, Chen CH, William I, Sooreshjani M, Bowie M, Hartley G, Dussold C  et al.  STING agonist 8803 reprograms the immune microenvironment and increases survival in preclinical models of glioblastoma.  J Clin Invest  2024 Jun 17;134(12). pii:e175033
  38. Moawad AW, Janas A, Baid U, Ramakrishnan D, Saluja R, Ashraf N, Jekel L, Amiruddin R, Adewole M, Albrecht J  et al.  The Brain Tumor Segmentation - Metastases (BraTS-METS) Challenge 2023: Brain Metastasis Segmentation on Pre-treatment MRI.  ArXiv  2024 Jun 17;. pii:arXiv:2306.00838v2
  39. Ghorbani A, Chatanaka MK, Avery LM, Wang M, Brown J, Cohen R, Gorham T, Misaghian S, Padmanabhan N, Romero D  et al.  Glial fibrillary acidic protein, neurofilament light, matrix metalloprotease 3 and fatty acid binding protein 4 as non-invasive brain tumor biomarkers.  Clin Proteomics  2024 Jun 15;21(1):41. pii:41
  40. Cherng HR, Qu M, Zafari Z, Bentzen SM, Armstrong TS, Gondi V, Brown PD, Mehta M, Mishra MV  Evaluating the sensitivity of EQ-5D-5L in patients with brain metastases: a secondary analysis of NRG CC001.  J Natl Cancer Inst  2024 Jun 07;116(6):983-989. doi:10.1093/jnci/djae020
  41. Arrieta VA, Gould A, Kim KS, Habashy KJ, Dmello C, Vázquez-Cervantes GI, Palacín-Aliana I, McManus G, Amidei C, Gomez C  et al.  Ultrasound-mediated delivery of doxorubicin to the brain results in immune modulation and improved responses to PD-1 blockade in gliomas.  Nat Commun  2024 Jun 06;15(1):4698. pii:4698
  42. Dixit K, Singer L, Grimm SA, Lukas RV, Schwartz MA, Rademaker A, Zhang H, Kocherginsky M, Chernet S, Sharp L  et al.  A Phase II Trial of Bevacizumab in Patients with Recurrent/Progressive Solid Tumor Brain Metastases That Have Progressed Following Whole-Brain Radiation Therapy.  Cancers (Basel)  2024 Jun 04;16(11). pii:2133
  43. Lucas CG, Mirchia K, Seo K, Najem H, Chen WC, Zakimi N, Foster K, Eaton CD, Cady MA, Choudhury A  et al.  Spatial genomic, biochemical and cellular mechanisms underlying meningioma heterogeneity and evolution.  Nat Genet  2024 Jun;56(6):1121-1133. doi:10.1038/s41588-024-01747-1
  44. Joy Trybula S, Nandoliya KR, Youngblood MW, Karras CL, Fernandez LG, Oyon DE, Texakalidis P, Khan OH, Lesniak MS, Tate MC  et al.  Predictors of salvage therapy for parasagittal meningiomas treated with primary surgery, radiosurgery, or surgery plus adjuvant radiotherapy.  J Clin Neurosci  2024 Jun;124:102-108. doi:10.1016/j.jocn.2024.04.024
  45. Khazanchi R, Nandoliya KR, Shahin MN, Rae AI, Chaliparambil RK, Bowden SG, Alwakeal A, Lopez Ramos CG, Stedelin B, Youngblood MW  et al.  Obesity and meningioma: a US population-based study paired with analysis of a multi-institutional cohort.  J Neurosurg  2024 Jun 01;140(6):1558-1567. doi:10.3171/2023.11.JNS23732
  46. Poppe MM, Tai A, Li XA, Miften M, Olch A, Marks LB, Qureshi BM, Spunt SL, Shnorhavorian M, Nelson G  et al.  Kidney Disease in Childhood Cancer Survivors Treated With Radiation Therapy: A PENTEC Comprehensive Review.  Int J Radiat Oncol Biol Phys  2024 Jun 01;119(2):560-574. doi:10.1016/j.ijrobp.2023.02.040
  47. Faisal SM, Ravi VM, Miska JM  Editorial: Spatiotemporal heterogeneity in CNS tumors.  Front Immunol  2024;15:1430227. pii:1430227
  48. Wang D, Geng H, Gondi V, Lee NY, Tsien CI, Xia P, Chenevert TL, Michalski JM, Gilbert MR, Le QT  et al.  Radiotherapy Plan Quality Assurance in NRG Oncology Trials for Brain and Head/Neck Cancers: An AI-Enhanced Knowledge-Based Approach.  Cancers (Basel)  2024 May 25;16(11). pii:2007
  49. Watanabe J, Clutter MR, Gullette MJ, Sasaki T, Uchida E, Kaur S, Mo Y, Abe K, Ishi Y, Takata N  et al.  BET bromodomain inhibition potentiates radiosensitivity in models of H3K27-altered diffuse midline glioma.  J Clin Invest  2024 May 21;134(13). pii:e174794
  50. Gruchala T, Smith H, Khan O, Jennings L, Santana-Santos L, Vormittag-Nocito E, Horbinski C  Epithelial differentiation mimicking tumor-to-tumor metastasis in an isocitrate dehydrogenase wild-type glioblastoma.  Neurooncol Adv  2024;6(1):vdae081. pii:vdae081
These are the publications from our team members that have been most recently indexed by PubMed. Visit PubMed to see more of our publications.

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