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Recent Publications

Browse recent studies from the Lou and Jean Malnati Brain Tumor Institute to learn more about our cutting-edge research.

  1. Gruchala T, Lewis CW, Abplanalp K, Jayabalan P, Walunas TL, Johnson JL, Wainwright DA, Lukas RV, Spill G, Roy I  Predicting medical prognosis in patients with glioblastoma during inpatient rehabilitation using bed mobility function.  PM R  2025 May 19;. doi:10.1002/pmrj.13402
  2. Turunen JR, Kumthekar P, Ahmed AU  Beyond the brain: exploring the impact of animal models of leptomeningeal disease from solid tumors.  Acta Neuropathol Commun  2025 May 19;13(1):103. pii:103
  3. Izhar M, Lesniak MS  Role of Extracellular Vesicles in the Pathogenesis of Brain Metastasis.  J Extracell Biol  2025 May;4(5):e70051. pii:e70051
  4. Beck JA, Mazcko C, Belluco S, Bitar M, Brat D, Bush JW, Chkheidze R, Corps KN, Frank C, Giannini C  et al.  Comparative pathology boards facilitate the translation of knowledge between canine and human cancer patients.  Brain Pathol  2025 May 05;:e70013. doi:10.1111/bpa.70013
  5. Pieters TA, Hersh AM, Elsamadicy AA, Pennington Z, Santangelo G, Najjar S, Hung B, Ber R, Atallah C, Efron J  et al.  Outcomes after en bloc resection with sacrectomy of advanced colorectal carcinomas that invade the sacrum: a multiinstitutional descriptive series.  J Neurosurg Spine  2025 May 01;42(5):598-604. doi:10.3171/2024.10.SPINE24391
  6. Tan S, Zhang Q, Zhan R, Luo S, Han Y, Yu B, Muss C, Pingault V, Marlin S, Delahaye A  et al.  Monoallelic loss-of-function variants in GSK3B lead to autism and developmental delay.  Mol Psychiatry  2025 May;30(5):1952-1965. doi:10.1038/s41380-024-02806-z
  7. Hou D, Wang S, Castro BA, Katz JL, Dapash M, Arrieta VA, Vazquez-Cervantes GI, Wan H, Billingham LK, Du R  et al.  Dual αVβ8 Integrin and PD-1 Blockade Overcomes TGFβ-Mediated B-Cell Suppression to Enhance Anti-Glioma Immunity.  Neuro Oncol  2025 Apr 22;. pii:noaf106
  8. Khalili BF, Dixit K, Kamson DO, Horbinski C, Przybyla DJ, Tate MC, Heimberger AB, Lukas RV, Templer JW  The excitatory milieu in glioma: mechanisms and therapeutic avenues.  Neuro Oncol  2025 Apr 18;. pii:noaf063
  9. Sperduto PW, Marqueen KE, Chang E, Li J, Davies MA, Ebner DK, Breen WG, Lamba N, Shih HA, Edwards D  et al.  Improved Survival and Prognostication in Melanoma Patients With Brain Metastases: An Update of the Melanoma Graded Prognostic Assessment.  J Clin Oncol  2025 Apr 17;:JCO2401351. doi:10.1200/JCO-24-01351
  10. Vormittag-Nocito E, Duckett D, Castellani RJ, Ahrendsen JT, Lu X, Jennings LJ, Lukas RV, Magill ST, Santana-Santos L, Brat DJ  et al.  Meningiomas With Chromosomal Polysomies Reveal Nonrandom Gain of Chromosomes, Distinct Methylation Signature, and Lower Risk of Recurrence.  Mod Pathol  2025 Apr 14;38(7):100775. doi:10.1016/j.modpat.2025.100775
  11. Tan PH, Ellis IO, Allison KH, Badve SS, Brogi E, Callagy G, Charafe-Jauffret E, Chen CJ, Chen YY, Collins LC  et al.  Malignant phyllodes tumours of the breast: the case for revising WHO's 'full house' diagnostic criteria.  Histopathology  2025 Apr 13;. doi:10.1111/his.15455
  12. Lee GY, Glicksman MA, Patel R, Malhotra S, Moelis N, Vanjani NN, Kumthekar P  Retrospective Review of Intra-Cerebrospinal Fluid (CSF) Drug Delivery in CNS Malignancies: Safety, Clinical Efficacy and Pharmacokinetic Profiles of Intracerebroventricular (ICV), Lumbar Intrathecal (LIT), and Intra-Cisterna Magna (ICM) Injections.  Cancers (Basel)  2025 Apr 09;17(8). pii:1263
  13. Seblani M, Zannikou M, Duffy JT, Joshi T, Levine RN, Thakur A, Puigdelloses-Vallcorba M, Horbinski CM, Miska J, Hambardzumyan D  et al.  IL13RA2-integrated genetically engineered mouse model allows for CAR T cells targeting pediatric high-grade gliomas.  Acta Neuropathol Commun  2025 Apr 02;13(1):69. pii:69
  14. Chia TY, Sadagopan NS, Miska J  Lipid peroxidation and immune activation: TRAF3's double-edged strategy against glioblastoma.  J Clin Invest  2025 Apr 01;135(7). pii:e190471
  15. Geurts M, Berchtold L, Koenig F, Nabors B, Reardon DA, Tonn JC, Stupp R, Gorlia T, Weller M, Preusser M  et al.  Temozolomide chemotherapy for patients with newly diagnosed glioblastoma in the CENTRIC EORTC 26071-22072 and CORE trials: Does time of administration matter?  Neurooncol Pract  2025 Apr;12(2):291-300. doi:10.1093/nop/npaf006
  16. Song X, Tiek D, Lu M, Yu X, Wu R, Walker M, He Q, Sisbarro D, Hu B, Cheng SY  A Single-Cell Atlas of RNA Alternative Splicing in the Glioma-Immune Ecosystem.  bioRxiv  2025 Mar 30;. pii:2025.03.26.645511
  17. Yu X, Song X, Tiek D, Wu R, Walker M, Horbinski C, Hu B, Cheng SY  Targeting PDGFRA-SHP2 Signaling Enhances Radiotherapy in IDH1-Mutant Glioma.  Neuro Oncol  2025 Mar 25;. pii:noaf086
  18. Seetharam D, Chandar J, Ramsoomair CK, Desgraves JF, Alvarado Medina A, Hudson AJ, Amidei A, Castro JR, Govindarajan V, Wang S  et al.  Activating antiviral immune responses potentiates immune checkpoint inhibition in glioblastoma models.  J Clin Invest  2025 Mar 17;135(6). pii:e183745
  19. Cheok SK, Ruzevick J, Briggs RG, Cote DJ, Shah I, Gomez D, Bove I, Feng JJ, Pangal DJ, Strickland BA  et al.  A contemporary, multiinstitutional analysis of transcription factor lineage in pituitary adenomas: comparative study of neuroimaging, histopathology, and clinical outcomes.  J Neurosurg  2025 Mar 14;:1-9. doi:10.3171/2024.10.JNS24853
  20. McCord M, Sears T, Wang W, Chaliparambil R, An S, Sarkaria J, James CD, Ruggeri B, Gueble S, Bindra R  et al.  The novel DNA cross-linking agent KL-50 is active against patient-derived models of new and recurrent post-temozolomide mismatch repair-deficient glioblastoma.  Neuro Oncol  2025 Mar 07;27(3):644-651. doi:10.1093/neuonc/noae257
  21. Feng H, Hu B, Vuori K, Sarkaria JN, Furnari FB, Cavenee WK, Cheng S-  Correction: EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180.  Oncogene  2025 Mar;44(10):710-711. doi:10.1038/s41388-025-03290-7
  22. Wu Y, Gao X, Liu Z, Wang P, Wu Z, Li Y, Zhang T, Liu T, Liu T, Li X  Decoding cortical folding patterns in marmosets using machine learning and large language model.  Neuroimage  2025 Mar;308:121031. doi:10.1016/j.neuroimage.2025.121031
  23. Pedder JH, Sonabend AM, Cearns MD, Michael BD, Zakaria R, Heimberger AB, Jenkinson MD, Dickens D  Crossing the blood-brain barrier: emerging therapeutic strategies for neurological disease.  Lancet Neurol  2025 Mar;24(3):246-260. doi:10.1016/S1474-4422(24)00476-9
  24. Geller JI, Renfro LA, Grundy PE, Perlman EJ, Kalapurakal JA, Ehrlich PF, Biegel J, Huff V, Warwick AB, Paulino A  et al.  Rhabdoid Tumor of the Kidney and Soft Tissues: Results from National Wilms Tumor Study-5 and Children's Oncology Group Study AREN0321.  Pediatr Blood Cancer  2025 Mar;72(3):e31490. doi:10.1002/pbc.31490
  25. Morshed RA, Nguyen MP, Youngblood MW, Perlow HK, Lucas CG, Patel AJ, Palmer JD, Chandler JP, Theodosopoulos PV, Magill ST  et al.  Gene Expression Changes Associated With Recurrence After Gross Total Resection of Newly Diagnosed World Health Organization Grade 1 Meningioma.  Neurosurgery  2025 Mar 01;96(3):521-528. doi:10.1227/neu.0000000000003133
  26. Xia Y, Papali P, Al-Mistarehi AH, Hansen LJ, Azad TD, Ahmed AK, Meyer C, Gross J, Khan M, Bettegowda C  et al.  Outcomes After Definitive Surgery for Spinal and Sacral Chordoma in 101 Patients Over 20 Years.  Neurosurgery  2025 Mar 01;96(3):494-504. doi:10.1227/neu.0000000000003130
  27. Sears TK, Wang W, Drumm M, Unruh D, McCord M, Horbinski C  F3 Expression Drives Sensitivity to the Antibody-Drug Conjugate Tisotumab Vedotin in Glioblastoma.  Cancers (Basel)  2025 Feb 27;17(5). pii:834
  28. Tripathy A, Corkos P, Blouw B, Montgomery DA, Moore M, Hedrick MH, Youssef M, Kumthekar PU  Longitudinal CSF Tumor Cell Enumeration and Mutational Analysis as a Driver for Leptomeningeal Disease Management.  Cancers (Basel)  2025 Feb 27;17(5). pii:825
  29. Monsen PJ, Bommi PV, Grigorescu AA, Lauing KL, Mao Y, Berardi P, Zhai L, Ojo O, Penco-Campillo M, Koch T  et al.  Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC).  J Med Chem  2025 Feb 27;68(4):4961-4987. doi:10.1021/acs.jmedchem.5c00026
  30. Fan X, Wang H, Lv X, Wang Q, Yu B, Li X, Li L, Zhang Y, Ma N, Lu Q  et al.  The pCREB/BDNF Pathway in the Hippocampus Is Involved in the Therapeutic Effect of Selective 5-HT Reuptake Inhibitors in Adult Male Rats Exposed to Blast Traumatic Brain Injury.  Brain Sci  2025 Feb 24;15(3). pii:236
  31. Tiek D, Song X, Yu X, Wu R, Iglesia R, Catezone A, McCortney K, Walshon J, Horbinski C, Jamshidi P  et al.  Oxidative stress induced protein aggregation via GGCT produced pyroglutamic acid in drug resistant glioblastoma.  iScience  2025 Feb 21;28(2):111769. pii:111769
  32. Li J, Shih LK, Markwell SM, Olson CL, Sullivan DP, Arvanitis C, Ross JL, Lam NG, Nuszen H, Hambardzumyan D  et al.  A clinically relevant model and method to study necrosis as a driving force in glioma restructuring and progression.  Proc Natl Acad Sci U S A  2025 Feb 18;122(7):e2416024122. pii:e2416024122
  33. Nguyen MP, Morshed RA, Youngblood MW, Perlow HK, Lucas CG, Patel AJ, Palmer JD, Horbinski CM, Magill ST, Chen WC  et al.  A targeted gene expression biomarker predicts clinic low-risk meningioma recurrence.  Neuro Oncol  2025 Feb 10;27(2):445-454. doi:10.1093/neuonc/noae198
  34. Sahm F, Aldape KD, Brastianos PK, Brat DJ, Dahiya S, von Deimling A, Giannini C, Gilbert MR, Louis DN, Raleigh DR  et al.  cIMPACT-NOW update 8: Clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas.  Neuro Oncol  2025 Feb 10;27(2):319-330. doi:10.1093/neuonc/noae170
  35. Le Rhun E, Nayak L, Lim-Fat MJ, Rudà R, Pentsova E, Forsyth P, O'Brien BJ, Preusser M, Kumthekar P, Brandsma D  et al.  NANO-LM: An updated scorecard for the clinical assessment of patients with leptomeningeal metastases.  Neuro Oncol  2025 Feb 10;27(2):455-465. doi:10.1093/neuonc/noae171
  36. Garcia-Fabiani MB, Haase S, Banerjee K, Zhu Z, McClellan BL, Mujeeb AA, Li Y, Tronrud CE, Varela ML, West MEJ  et al.  H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Diffuse Hemispheric Gliomas.  bioRxiv  2025 Feb 05;. pii:2023.06.13.544658
  37. Fares J, Petrosyan E, Dmello C, Lukas RV, Stupp R, Lesniak MS  Rethinking metastatic brain cancer as a CNS disease.  Lancet Oncol  2025 Feb;26(2):e111-e121. doi:10.1016/S1470-2045(24)00430-3
  38. Gondi V, Deshmukh S, Brown PD, Wefel JS, Armstrong TS, Tome WA, Gilbert MR, Konski A, Robinson CG, Bovi JA  et al.  Erratum to: Gondi V, Deshmukh S, Brown PD, et al. Sustained Preservation of Cognition and Prevention of Patient-Reported Symptoms With Hippocampal Avoidance During Whole-Brain Radiation Therapy for Brain Metastases: Final Results of NRG Oncology CC001. Int J Radiat Oncol Biol Phys. 2023;117:571-580.  Int J Radiat Oncol Biol Phys  2025 Feb 01;121(2):571-572. doi:10.1016/j.ijrobp.2024.08.041
  39. Khalili BF, Walbert T, Horbinski C, Dixit K, Gururangan K, Thio H, Tate MC, Stupp R, Lukas RV, Templer JW  Levetiracetam and valproic acid in glioma: antiseizure and potential antineoplastic effects.  Future Oncol  2025 Feb;21(4):483-491. doi:10.1080/14796694.2025.2450215
  40. Sloan AR, Gordillo AJ, Kennemer A, Khorana AA, Horbinski C, Kaelber DC, Cameron SJ, Lathia JD  Venous thromboembolism incidence shortens survival in isocitrate dehydrogenase wild-type glioblastoma.  Neurooncol Adv  2025;7(1):vdaf018. pii:vdaf018
  41. Armstrong AE, Daw NC, Renfro LA, Geller JI, Kalapurakal JA, Khanna G, Paulino AC, Perlman EJ, Ehrlich PF, Gow KW  et al.  Treatment of focal anaplastic Wilms tumor: A report from the Children's Oncology Group AREN0321 and AREN03B2 studies.  Cancer  2025 Jan 15;131(2):e35713. doi:10.1002/cncr.35713
  42. Kotecha R, Akdemir EY, Kutuk T, Ilgin C, Ahluwalia MS, Bi WL, Blakeley J, Dixit KS, Dunn IF, Galanis E  et al.  Benchmarking the Efficacy of Salvage Systemic Therapies for Recurrent Meningioma: A RANO Group Systematic Review and Meta-analysis to Guide Clinical Trial Design.  Neuro Oncol  2025 Jan 14;. pii:noaf009
  43. Zhou X, Xia Q, Wang B, Li J, Liu B, Wang S, Huang M, Zhong R, Cheng SY, Wang X  et al.  USP14 modulates stem-like properties, tumorigenicity, and radiotherapy resistance in glioblastoma stem cells through stabilization of MST4-phosphorylated ALKBH5.  Theranostics  2025;15(6):2293-2314. doi:10.7150/thno.103629
  44. Du R, Zhang J, Lukas RV, Tripathi S, Ahrendsen JT, Curran MA, Dmello C, Zhang P, Stupp R, Rao G  et al.  Is modulation of immune checkpoints on glioblastoma-infiltrating myeloid cells a viable therapeutic strategy?  Neuro Oncol  2025 Jan 12;27(1):33-49. doi:10.1093/neuonc/noae193
  45. Fernandopulle MS, Cotty-Fattal Z, Smith H, Mejia Bautista M, Ahrendsen JT, Jennings LJ, Santana-Santos L, Sukhanova M, Conway K, Primdahl D  et al.  Dual TERT promoter mutations in an oligodendroglioma, IDH-mutant, 1p/19q co-deleted.  J Neuropathol Exp Neurol  2025 Jan 11;. pii:nlae138
  46. Duckett D, Vormittag-Nocito ER, Jamshidi P, Sukhanova M, Parker S, Brat DJ, Jennings LJ, Santana-Santos L  Accurate identification of primary site in tumors of unknown origin (TUO) using DNA methylation.  NPJ Precis Oncol  2025 Jan 10;9(1):8. pii:8
  47. Malhotra J, Mambetsariev I, Gilmore G, Fricke J, Nam A, Gallego N, Chen BT, Chen M, Amini A, Lukas RV  et al.  Targeting CNS Metastases in Non-Small Cell Lung Cancer With Evolving Approaches Using Molecular Markers: A Review.  JAMA Oncol  2025 Jan 01;11(1):60-69. doi:10.1001/jamaoncol.2024.5218
  48. Ziu M, Halasz LM, Kumthekar PU, McGranahan TM, Lo SS, Olson JJ  Congress of Neurological Surgeons systematic review and evidence-based guidelines for the role of chemotherapy in newly diagnosed WHO Grade II diffuse glioma in adults: update.  J Neurooncol  2025 Jan;171(2):279-298. doi:10.1007/s11060-024-04861-6
  49. Smith H, Jean J, Duckett D, Vormittag-Nocito E, Nezami BG, Jennings LJ, Ahrendsen JT, Yang XJ, Primdahl D, Conway K  et al.  Diagnostic utility of multimodal advanced molecular testing to classify metastases of unknown primaries: A case of a patient with no known medical history.  J Neuropathol Exp Neurol  2025 Jan 01;84(1):84-86. doi:10.1093/jnen/nlae086
  50. Gould A, Luan Y, Hou Y, Korobova FV, Chen L, Arrieta VA, Amidei C, Ward R, Gomez C, Castro B  et al.  Endothelial response to blood-brain barrier disruption in the human brain.  JCI Insight  2024 Dec 26;10(4). pii:e187328
These are the publications from our team members that have been most recently indexed by PubMed. Visit PubMed to see more of our publications.

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