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Recent Publications

Browse recent studies from the Lou and Jean Malnati Brain Tumor Institute to learn more about our cutting-edge research.

  1. Thirunavu V, Drumm M, McCord M, Steffens A, Youngblood MW, Nandoliya KR, Smith H, Walshon J, McCortney K, Magill ST  et al.  Optimizing the use of Ki-67 proliferative index as a prognostic biomarker in meningiomas using digital analysis.  J Neurosurg  2024 Jul 05;:1-11. doi:10.3171/2024.4.JNS232857
  2. Kostelecky N, Wadhwani N, Golubovich I, Vormittag-Nocito E, Gao J, Jennings L, Caron M, Jamshidi P, Ahrendsen JT, Castellani R  et al.  Transdifferentiation of metastatic melanoma into cerebellar angiosarcoma.  J Neuropathol Exp Neurol  2024 Jul 04;. pii:nlae075
  3. Lyons CE, Dixit K  Elsberg Syndrome: A Case Report of a Novel Radiographic Presentation.  Neurohospitalist  2024 Jul;14(3):347-350. doi:10.1177/19418744241241107
  4. Rudà R, Horbinski C, van den Bent M, Preusser M, Soffietti R  IDH inhibition in gliomas: from preclinical models to clinical trials.  Nat Rev Neurol  2024 Jul;20(7):395-407. doi:10.1038/s41582-024-00967-7
  5. Huang ZL, Liu ZG, Lin Q, Tao YL, Li X, Baxter P, Su JM, Adesina AM, Man C, Chintagumpala M  et al.  Fractionated radiation therapy alters energy metabolism and induces cellular quiescence exit in patient-derived orthotopic xenograft models of high-grade glioma.  Transl Oncol  2024 Jul;45:101988. pii:101988
  6. Rabin EE, Huang J, Kim M, Mozny A, Lauing KL, Penco-Campillo M, Zhai L, Bommi P, Mi X, Power EA  et al.  Age-stratified comorbid and pharmacologic analysis of patients with glioblastoma.  Brain Behav Immun Health  2024 Jul;38:100753. pii:100753
  7. Benedetti DJ, Renfro LA, Tfirn I, Daw NC, Kalapurakal JA, Ehrlich PF, Khanna G, Perlman E, Warwick A, Gow KW  et al.  Treatment and outcomes of clear cell sarcoma of the kidney: A report from the Children's Oncology Group studies AREN0321 and AREN03B2.  Cancer  2024 Jul 01;130(13):2361-2371. doi:10.1002/cncr.35266
  8. Mrugala MM, Shi W, Iwomoto F, Lukas RV, Palmer JD, Suh JH, Glas M  Global post‑marketing safety surveillance of Tumor Treating Fields (TTFields) therapy in over 25,000 patients with CNS malignancies treated between 2011-2022.  J Neurooncol  2024 Jun 29;. doi:10.1007/s11060-024-04682-7
  9. Liggett MR, Lashley S, Gill NP, Scholtens DM, Dawood ZS, Alam HB  Plasma therapy for traumatic brain injury: Rationale for a prospective randomized trial.  Transfusion  2024 Jun 28;. doi:10.1111/trf.17928
  10. Ellingson BM, Sanvito F, Cloughesy TF, Huang RY, Villanueva-Meyer JE, Pope WB, Barboriak DP, Shankar LK, Smits M, Kaufmann TJ  et al.  A Neuroradiologist's Guide to Operationalizing the Response Assessment in Neuro-Oncology (RANO) Criteria Version 2.0 for Gliomas in Adults.  AJNR Am J Neuroradiol  2024 Jun 28;. pii:ajnr.A8396
  11. Li X, Nguyen TTA, Zhang J, Nayak A, Liu Y, Duckworth LA, Zhang G, Bakkar R, Agarwal I, Hou Y  et al.  Validation Study of the Newly Proposed Refined Diagnostic Criteria for Malignant Phyllodes Tumor With 136 Borderline and Malignant Phyllodes Tumor Cases.  Am J Surg Pathol  2024 Jun 27;. doi:10.1097/PAS.0000000000002264
  12. van den Bent MJ, French PJ, Brat D, Tonn JC, Touat M, Ellingson BM, Young RJ, Pallud J, von Deimling A, Sahm F  et al.  The biological significance of tumor grade, age, enhancement and extent of resection in IDH mutant gliomas: how should they inform treatment decision in the era of IDH inhibitors? Invited review.  Neuro Oncol  2024 Jun 24;. pii:noae107
  13. Wilcox JA, Chukwueke UN, Ahn MJ, Aizer AA, Bale TA, Brandsma D, Brastianos PK, Chang S, Daras M, Forsyth P  et al.  Leptomeningeal metastases from solid tumors: A SNO and ASCO consensus review on clinical management and future directions.  Neuro Oncol  2024 Jun 21;. pii:noae103
  14. Panek WK, Toedebusch RG, Mclaughlin BE, Dickinson PJ, Dyke JE, Woolard KD, Berens ME, Lesniak MS, Sturges BK, Vernau KM  et al.  The CCL2-CCR4 Axis Promotes Regulatory T Cell Trafficking to Canine Glioma Tissues.  Res Sq  2024 Jun 17;. pii:rs.3.rs-4474288
  15. Najem H, Lea ST, Tripathi S, Hurley L, Chen CH, William I, Sooreshjani M, Bowie M, Hartley G, Dussold C  et al.  STING agonist 8803 reprograms the immune microenvironment and increases survival in preclinical models of glioblastoma.  J Clin Invest  2024 Jun 17;134(12). pii:e175033
  16. Moawad AW, Janas A, Baid U, Ramakrishnan D, Saluja R, Ashraf N, Jekel L, Amiruddin R, Adewole M, Albrecht J  et al.  The Brain Tumor Segmentation - Metastases (BraTS-METS) Challenge 2023: Brain Metastasis Segmentation on Pre-treatment MRI.  ArXiv  2024 Jun 17;. pii:arXiv:2306.00838v2
  17. Ghorbani A, Chatanaka MK, Avery LM, Wang M, Brown J, Cohen R, Gorham T, Misaghian S, Padmanabhan N, Romero D  et al.  Glial fibrillary acidic protein, neurofilament light, matrix metalloprotease 3 and fatty acid binding protein 4 as non-invasive brain tumor biomarkers.  Clin Proteomics  2024 Jun 15;21(1):41. pii:41
  18. Yang Y, Wadhwani N, Shimomura A, Zheng S, Chandler J, Lesniak MS, Tate MC, Sonabend AM, Kalapurakal J, Horbinski C  et al.  Long-term outcomes of central neurocytoma - an institutional experience.  J Neurooncol  2024 Jun 12;. doi:10.1007/s11060-024-04713-3
  19. Cherng HR, Qu M, Zafari Z, Bentzen SM, Armstrong TS, Gondi V, Brown PD, Mehta M, Mishra MV  Evaluating the sensitivity of EQ-5D-5L in patients with brain metastases: a secondary analysis of NRG CC001.  J Natl Cancer Inst  2024 Jun 07;116(6):983-989. doi:10.1093/jnci/djae020
  20. Arrieta VA, Gould A, Kim KS, Habashy KJ, Dmello C, Vázquez-Cervantes GI, Palacín-Aliana I, McManus G, Amidei C, Gomez C  et al.  Ultrasound-mediated delivery of doxorubicin to the brain results in immune modulation and improved responses to PD-1 blockade in gliomas.  Nat Commun  2024 Jun 06;15(1):4698. pii:4698
  21. Dixit K, Singer L, Grimm SA, Lukas RV, Schwartz MA, Rademaker A, Zhang H, Kocherginsky M, Chernet S, Sharp L  et al.  A Phase II Trial of Bevacizumab in Patients with Recurrent/Progressive Solid Tumor Brain Metastases That Have Progressed Following Whole-Brain Radiation Therapy.  Cancers (Basel)  2024 Jun 04;16(11). pii:2133
  22. Qi L, Du Y, Huang Y, Kogiso M, Zhang H, Xiao S, Abdallah A, Suarez M, Niu L, Liu ZG  et al.  CD57 defines a novel cancer stem cell that drive invasion of diffuse pediatric-type high grade gliomas.  Br J Cancer  2024 Jun 04;. doi:10.1038/s41416-024-02724-5
  23. Xu C, Chen G, Yu B, Sun B, Zhang Y, Zhang M, Yang Y, Xiao Y, Cheng SY, Li Y  et al.  TRIM24 Cooperates with Ras Mutation to Drive Glioma Progression through snoRNA Recruitment of PHAX and DNA-PKcs.  Adv Sci (Weinh)  2024 Jun 03;:e2400023. doi:10.1002/advs.202400023
  24. Lucas CG, Mirchia K, Seo K, Najem H, Chen WC, Zakimi N, Foster K, Eaton CD, Cady MA, Choudhury A  et al.  Spatial genomic, biochemical and cellular mechanisms underlying meningioma heterogeneity and evolution.  Nat Genet  2024 Jun;56(6):1121-1133. doi:10.1038/s41588-024-01747-1
  25. Joy Trybula S, Nandoliya KR, Youngblood MW, Karras CL, Fernandez LG, Oyon DE, Texakalidis P, Khan OH, Lesniak MS, Tate MC  et al.  Predictors of salvage therapy for parasagittal meningiomas treated with primary surgery, radiosurgery, or surgery plus adjuvant radiotherapy.  J Clin Neurosci  2024 Jun;124:102-108. doi:10.1016/j.jocn.2024.04.024
  26. Khazanchi R, Nandoliya KR, Shahin MN, Rae AI, Chaliparambil RK, Bowden SG, Alwakeal A, Lopez Ramos CG, Stedelin B, Youngblood MW  et al.  Obesity and meningioma: a US population-based study paired with analysis of a multi-institutional cohort.  J Neurosurg  2024 Jun 01;140(6):1558-1567. doi:10.3171/2023.11.JNS23732
  27. Poppe MM, Tai A, Li XA, Miften M, Olch A, Marks LB, Qureshi BM, Spunt SL, Shnorhavorian M, Nelson G  et al.  Kidney Disease in Childhood Cancer Survivors Treated With Radiation Therapy: A PENTEC Comprehensive Review.  Int J Radiat Oncol Biol Phys  2024 Jun 01;119(2):560-574. doi:10.1016/j.ijrobp.2023.02.040
  28. Faisal SM, Ravi VM, Miska JM  Editorial: Spatiotemporal heterogeneity in CNS tumors.  Front Immunol  2024;15:1430227. pii:1430227
  29. Wang D, Geng H, Gondi V, Lee NY, Tsien CI, Xia P, Chenevert TL, Michalski JM, Gilbert MR, Le QT  et al.  Radiotherapy Plan Quality Assurance in NRG Oncology Trials for Brain and Head/Neck Cancers: An AI-Enhanced Knowledge-Based Approach.  Cancers (Basel)  2024 May 25;16(11). pii:2007
  30. Watanabe J, Clutter MR, Gullette MJ, Sasaki T, Uchida E, Kaur S, Mo Y, Abe K, Ishi Y, Takata N  et al.  BET bromodomain inhibition potentiates radiosensitivity in models of H3K27-altered diffuse midline glioma.  J Clin Invest  2024 May 21;134(13). pii:e174794
  31. Gruchala T, Smith H, Khan O, Jennings L, Santana-Santos L, Vormittag-Nocito E, Horbinski C  Epithelial differentiation mimicking tumor-to-tumor metastasis in an isocitrate dehydrogenase wild-type glioblastoma.  Neurooncol Adv  2024;6(1):vdae081. pii:vdae081
  32. Raleigh DR, Chen WC, Gondi V, Rogers L, Mehta M  Implications and interchangeability of meningioma biomarkers for clinical trials and clinical practice.  J Neurooncol  2024 May 14;. doi:10.1007/s11060-024-04700-8
  33. Choudhury A, Cady MA, Lucas CG, Najem H, Phillips JJ, Palikuqi B, Zakimi N, Joseph T, Birrueta JO, Chen WC  et al.  Perivascular NOTCH3+ stem cells drive meningioma tumorigenesis and resistance to radiotherapy.  Cancer Discov  2024 May 14;. doi:10.1158/2159-8290.CD-23-1459
  34. Du R, Tripathi S, Najem H, Brat DJ, Lukas RV, Zhang P, Heimberger AB  Glioblastoma Phagocytic Cell Death: Balancing the Opportunities for Therapeutic Manipulation.  Cells  2024 May 11;13(10). pii:823
  35. Li X, Lu S, Ge L, Li Z, Chen R, Zu Y, Fu R, Li L, Wang C  Repetitive Transcranial Magnetic Stimulation Combined with Sling Exercise Modulates the Motor Cortex in Patients with Chronic Low Back Pain.  Neuroscience  2024 May 03;545:196-206. doi:10.1016/j.neuroscience.2024.03.011
  36. Cherng HR, Sun K, Bentzen S, Armstrong TS, Gondi V, Brown PD, Mehta M, Mishra MV  Evaluating the heterogeneity of hippocampal avoidant whole brain radiotherapy treatment effect: A secondary analysis of NRG CC001.  Neuro Oncol  2024 May 03;26(5):911-921. doi:10.1093/neuonc/noad226
  37. Li J, Shih LK, Brat DJ  Integrated Proteogenomics Uncover Mechanisms of Glioblastoma Evolution, Pointing to Novel Therapeutic Targets.  Cancer Res  2024 May 02;84(9):1379-1381. doi:10.1158/0008-5472.CAN-24-0452
  38. Arrillaga-Romany I, Gardner SL, Odia Y, Aguilera D, Allen JE, Batchelor T, Butowski N, Chen C, Cloughesy T, Cluster A  et al.  ONC201 (Dordaviprone) in Recurrent H3 K27M-Mutant Diffuse Midline Glioma.  J Clin Oncol  2024 May 01;42(13):1542-1552. doi:10.1200/JCO.23.01134
  39. Trybula SJ, Youngblood MW, Karras CL, Murthy NK, Heimberger AB, Lukas RV, Sachdev S, Kalapurakal JA, Chandler JP, Brat DJ  et al.  The Evolving Classification of Meningiomas: Integration of Molecular Discoveries to Inform Patient Care.  Cancers (Basel)  2024 Apr 30;16(9). pii:1753
  40. Qi L, Baxter P, Kogiso M, Zhang H, Braun FK, Lindsay H, Zhao S, Xiao S, Abdallah AS, Suarez M  et al.  Direct Implantation of Patient Brain Tumor Cells into Matching Locations in Mouse Brains for Patient-Derived Orthotopic Xenograft Model Development.  Cancers (Basel)  2024 Apr 28;16(9). pii:1716
  41. Kumthekar P, Lyleroehr M, Lacson L, Lukas RV, Dixit K, Stupp R, Kruser T, Raizer J, Hou A, Sachdev S  et al.  A qualitative evaluation of factors influencing Tumor Treating fields (TTFields) therapy decision making among brain tumor patients and physicians.  BMC Cancer  2024 Apr 25;24(1):527. pii:527
  42. Zhang Q, Gao S, Li B, Li Q, Li X, Cheng J, Peng Z, Liang J, Zhang K, Hai J  et al.  Lithium-Doped Titanium Dioxide-Based Multilayer Hierarchical Structure for Accelerating Nerve-Induced Bone Regeneration.  ACS Appl Mater Interfaces  2024 Apr 25;16(18):22887-99. doi:10.1021/acsami.4c01520
  43. Song X, Tiek D, Miki S, Huang T, Lu M, Goenka A, Iglesia R, Yu X, Wu R, Walker M  et al.  RNA splicing analysis deciphers developmental hierarchies and reveals therapeutic targets in adult glioma.  J Clin Invest  2024 Apr 25;134(11). pii:e173789
  44. Shireman JM, White Q, Ni Z, Mohanty C, Cai Y, Zhao L, Agrawal N, Gonugunta N, Wang X, Mccarthy L  et al.  Genomic analysis of human brain metastases treated with stereotactic radiosurgery reveals unique signature based on treatment failure.  iScience  2024 Apr 19;27(4):109601. pii:109601
  45. Zhang S, Zhang T, Cao G, Zhou J, He Z, Li X, Ren Y, Liu T, Jiang X, Guo L  et al.  Species -shared and -unique gyral peaks on human and macaque brains.  Elife  2024 Apr 18;12. pii:RP90182
  46. Habashy KJ, Dmello C, Chen L, Arrieta VA, Kim KS, Gould A, Youngblood MW, Bouchoux G, Burdett KB, Zhang H  et al.  Paclitaxel and Carboplatin in Combination with Low-intensity Pulsed Ultrasound for Glioblastoma.  Clin Cancer Res  2024 Apr 15;30(8):1619-1629. doi:10.1158/1078-0432.CCR-23-2367
  47. Zhang QS, Hayes JP, Gondi V, Pollack SM  Immunotherapy and Radiotherapy Combinations for Sarcoma.  Semin Radiat Oncol  2024 Apr;34(2):229-242. doi:10.1016/j.semradonc.2023.12.005
  48. Budhiraja S, McManus G, Baisiwala S, Perrault EN, Cho S, Saathoff M, Chen L, Park CH, Kazi HA, Dmello C  et al.  ARF4-mediated retrograde trafficking as a driver of chemoresistance in GBM.  Neuro Oncol  2024 Mar 20;. pii:noae059
  49. Benedetti DJ, Varela CR, Renfro LA, Tornwall B, Dix DB, Ehrlich PF, Glick RD, Kalapurakal J, Perlman E, Gratias E  et al.  Treatment of children with favorable histology Wilms tumor with extrapulmonary metastases: A report from the COG studies AREN0533 and AREN03B2 and NWTSG study NWTS-5.  Cancer  2024 Mar 15;130(6):947-961. doi:10.1002/cncr.35099
  50. Khan F, Lin Y, Ali H, Pang L, Dunterman M, Hsu WH, Frenis K, Grant Rowe R, Wainwright DA, McCortney K  et al.  Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression.  Nat Commun  2024 Mar 05;15(1):1987. pii:1987
These are the publications from our team members that have been most recently indexed by PubMed. Visit PubMed to see more of our publications.

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