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Recent Publications

Browse recent studies from the Lou and Jean Malnati Brain Tumor Institute to learn more about our cutting-edge research.

  1. He Z, Li W, Liu T, Li X, Han J, Zhang T, Yuan Y  GAGM: Geometry-aware graph matching framework for weakly supervised gyral hinge correspondence.  Med Image Anal  2026 Jan;107(Pt A):103820. doi:10.1016/j.media.2025.103820
  2. Sadagopan NS, Gomez M, Tripathi S, Billingham LK, DeLay SL, Cady MA, Congivaram HTS, Chia TY, Wan H, Wang S  et al.  NOTCH3 drives fatty acid oxidation and ferroptosis resistance in aggressive meningiomas.  J Neurooncol  2025 Dec;175(3):979-991. doi:10.1007/s11060-025-05208-5
  3. Myneni S, Tang L, Akbari H, Mayne R, Kazemi F, Xiong R, Redmond KJ, Bilsky MH, Charest-Morin R, Tobert DG  et al.  The Spinal Chordoma Patient Reported Outcome Survey (spCPROS): a patient-centered, disease-specific tool for assessing quality of life in spinal chordoma patients.  J Neurooncol  2025 Nov;175(2):813-824. doi:10.1007/s11060-025-05181-z
  4. Corn BW, Paulus R, Gondi V, Mehta MP, Fogh S, Wefel JS, Videtic GM, Sun A, Yoon H, Heinzerling JH  et al.  "Hope" Drives Quality of Life in Patients With Brain Metastases, But, the "Hope Center" Remains Elusive: An Analysis of NRG-CC003.  Int J Radiat Oncol Biol Phys  2025 Nov 01;123(3):642-652. doi:10.1016/j.ijrobp.2025.06.3884
  5. Cherng HR, Sun K, Bentzen SM, Brown PD, Armstrong TS, Palmer JD, Gondi V, Mehta MP, Mishra MV  Redefining Neurocognitive Outcomes After Radiation for Brain Metastases: A Patient-Level Meta-Analysis of Recovery Following Initial Decline.  J Natl Cancer Inst  2025 Oct 22;. pii:djaf264
  6. Barnes A, Gaikwad HK, Siegel D, Angarita D, Nebbia M, Anchordoquy T, Bourne D, Stewart M, Yildirim A, Fierro Cota MM  et al.  Role of Serum Stability and Lipoprotein Interactions in Lipid Structure-Tumor Accumulation Relationship.  ACS Nano  2025 Oct 21;19(41):36435-36450. doi:10.1021/acsnano.5c10594
  7. Hou D, Wang S, Castro BA, Katz JL, Dapash M, Arrieta VA, Vazquez-Cervantes GI, Wan H, Billingham LK, Du R  et al.  Dual aVß8 Integrin and PD-1 Blockade Overcomes TGFβ-Mediated B-Cell Suppression to Enhance Anti-Tumor Immunity.  Neuro Oncol  2025 Oct 14;27(9):2355-2369. doi:10.1093/neuonc/noaf106
  8. Sears TK, McCord M, Wang W, Steffens A, McCortney K, Chaliparambil R, Sarkaria JN, Horbinski CM  Methylation-induced suppression of YAP/TAZ confers sensitivity to HDAC inhibitors in high grade IDH mutant gliomas.  JCI Insight  2025 Oct 09;. pii:e195385
  9. Li J, Ross JL, Hambardzumyan D, Brat DJ  Immunopathology of Glioblastoma.  Annu Rev Pathol  2025 Oct 08;. doi:10.1146/annurev-pathmechdis-042524-025950
  10. Liang K, Zhou W, Li X, Wu J, Li D, Xie Y, Wei X  Quantitative analysis and trends in the study of the effects of electromagnetic radiation on the nervous system from a bibliometric perspective.  Electromagn Biol Med  2025 Oct 03;:1-14. doi:10.1080/15368378.2025.2568667
  11. Lo SS, Halasz LM, Choi S, Kumthekar P, Wang TJC, Shu HK, Sloan AE, Olson JJ  Congress of Neurological Surgeons systematic review and evidence-based guidelines for the role of radiotherapy in the management of patients with diffuse low grade glioma in adults: update.  J Neurooncol  2025 Oct;175(1):21-33. doi:10.1007/s11060-025-05074-1
  12. Xia Y, Papali P, Al-Mistarehi AH, Ahmed AK, Hansen LJ, Meyer C, Gross J, Khan M, Winkle M, Bettegowda C  et al.  Long-term functional outcomes and their relationship to nerve root sacrifice after definitive surgery for sacrococcygeal chordoma.  J Neurosurg Spine  2025 Oct 01;43(4):481-488. doi:10.3171/2025.3.SPINE241408
  13. Ali H, Zhou N, Chen L, van Hijfte L, Tulaiha R, Karri V, Zhou Y, Habashy K, Arrieta VA, Kim KS  et al.  YBX1&YBX3 as novel targets to potentiate immune checkpoint blockade response in gliomas.  Neuro Oncol  2025 Sep 30;. pii:noaf227
  14. Mehta MP, Gondi V, Ahluwalia MS, Roberge D, Sio TTW, Trifiletti DM, Muanza T, Krpan AM, Zhu Z, Ramakrishna NR  et al.  Tumor Treating Fields (TTFields) therapy after stereotactic radiosurgery for brain metastases from non-small cell lung cancer: final results of the phase 3 METIS study.  Int J Radiat Oncol Biol Phys  2025 Sep 29;. pii:S0360-3016(25)06217-0
  15. Wainwright D, Lukas R, Zhai L, Lauing K, Kim M, Koch T, Penco-Campillo M, Bommi P, Dixit K, Kumthekar P  et al.  Newly diagnosed glioblastoma IDHwt patients treated with radiation, nivolumab, and BMS-986205.  Res Sq  2025 Sep 25;. pii:rs.3.rs-7567487
  16. Pour-Rashidi A, Zandpazandi S, Perronne L, Hill VB, Krumpelman C, Subedi K, Kelahan L, Borhani AA, Savas H, Avery R  et al.  Intracranial Metastases from Uterine Leiomyosarcoma: A Systematic Review and Case Illustration.  J Clin Med  2025 Sep 20;14(18). pii:6631
  17. Lassman AB, Polley MC, Iwamoto FM, Sloan AE, Wang TJC, Aldape KD, Wefel JS, Gondi V, Gutierrez AN, Manasawala MH  et al.  Dual Immune Check Point Blockade in MGMT-Unmethylated Newly Diagnosed Glioblastoma: NRG Oncology BN007, a Randomized Phase II/III Clinical Trial.  J Clin Oncol  2025 Sep 20;43(27):3032-3040. doi:10.1200/JCO-25-00618
  18. Khan F, Petrosyan E, Liu Y, Bahrami A, Taefi E, Geula C, Lesniak MS, Chen P  Microglial TBK1 Signaling Promotes Breast Cancer Brain Metastasis.  Cancer Res  2025 Sep 18;. doi:10.1158/0008-5472.CAN-25-1791
  19. Khalili BF, Dixit K, Kamson DO, Horbinski C, Przybyla DJ, Tate MC, Heimberger AB, Lukas RV, Templer JW  The excitatory milieu in glioma: Mechanisms and therapeutic avenues.  Neuro Oncol  2025 Sep 17;27(8):1932-1945. doi:10.1093/neuonc/noaf063
  20. Yu X, Song X, Tiek D, Wu R, Walker M, Horbinski C, Hu B, Cheng SY  Targeting PDGFRA-SHP2 signaling enhances radiotherapy in IDH1-mutant glioma.  Neuro Oncol  2025 Sep 17;27(8):2023-2034. doi:10.1093/neuonc/noaf086
  21. Weber-Levine C, Xia Y, Al-Mistarehi AH, Jiang K, Mendelson BZ, Antar A, Ksabi NL, Zaitoun KJ, Papali P, Neerumalla S  et al.  The Impact of Expansile Duraplasty After Resection of Intramedullary Astrocytomas.  Oper Neurosurg  2025 Sep 16;. doi:10.1227/ons.0000000000001762
  22. Núñez FJ, Banerjee K, Mujeeb AA, Mauser A, Tronrud CE, Zhu Z, Raghuram S, Sheth MR, Agudelo JAP, Zelaya J  et al.  Autophagy Upregulation in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma Uncovers a Novel Therapeutic Target.  Res Sq  2025 Sep 11;. pii:rs.3.rs-7483444
  23. Kotecha R, Akdemir EY, Kutuk T, Ilgın C, Ahluwalia MS, Bi WL, Blakeley J, Dixit KS, Dunn IF, Galanis E  et al.  Benchmarking the efficacy of salvage systemic therapies for recurrent meningioma: A RANO group systematic review and meta-analysis to guide clinical trial design.  Neuro Oncol  2025 Sep 08;27(7):1670-1685. doi:10.1093/neuonc/noaf009
  24. Gui C, Wang JZ, Patil V, Landry AP, Singh O, Castelo-Branco P, Tabori U, Aldape K, Behling F, Barnholtz-Sloan JS  et al.  Analysis of TERT association with clinical outcome in meningiomas: a multi-institutional cohort study.  Lancet Oncol  2025 Sep;26(9):1191-1203. doi:10.1016/S1470-2045(25)00267-0
  25. Groff KJ, Patel RV, Feng Y, Ghosh HS, Millares Chavez MA, O'Brien J, Chen WC, Nitturi V, Save AV, Youngblood MW  et al.  The effect of TERT promoter mutation on predicting meningioma outcomes: a multi-institutional cohort analysis.  Lancet Oncol  2025 Sep;26(9):1178-1190. doi:10.1016/S1470-2045(25)00422-X
  26. Nassiri F, Patil V, Yefet LS, Singh O, Liu J, Dang RMA, Yamaguchi TN, Daras M, Cloughesy TF, Colman H  et al.  Author Correction: Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial.  Nat Med  2025 Sep;31(9):3204. doi:10.1038/s41591-025-03895-1
  27. Beck JA, Mazcko C, Belluco S, Bitar M, Brat D, Bush JW, Chkheidze R, Corps KN, Frank C, Giannini C  et al.  Comparative pathology boards facilitate the translation of knowledge between canine and human cancer patients.  Brain Pathol  2025 Sep;35(5):e70013. pii:e70013
  28. Benato A, Texakalidis P, Wolinsky JP  Reconstruction of posterior elements of the spine with femoral shaft allograft after spondylectomy for En bloc resection of tumor.  Eur Spine J  2025 Aug 14;. doi:10.1007/s00586-025-09141-z
  29. Feng Y, Haupt B, Huynh TT, Meshaw R, Martin-Regalado A, Thakur A, Duffy JT, Alzeer A, Siegel DA, Barnes A  et al.  Longitudinal Imaging Reveals Tumor Uptake and Prolonged Retention of Bispecific T Cell-Engaging Antibody in GBM via Passive and Active Mechanisms.  Clin Cancer Res  2025 Aug 14;31(16):3537-3549. doi:10.1158/1078-0432.CCR-24-4194
  30. Habashy KJ, Synold TW, Feng Y, Gomez C, Amidei C, Ward R, VanderMolen S, Zarrieneh A, Kim KS, Gomez M  et al.  Pharmacokinetic Analysis of Carboplatin and Fluorescein Brain Retention following Ultrasound-Based Blood-Brain Barrier Opening.  Clin Cancer Res  2025 Aug 14;31(16):3562-3570. doi:10.1158/1078-0432.CCR-25-0080
  31. Wen PY, Weller M, Lee EQ, Touat M, Khasraw M, Rahman R, Platten M, Lim M, Winkler F, Horbinski C  et al.  Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions.  Neuro Oncol  2025 Aug 13;. pii:noaf177
  32. Gondi V, Pugh SL, Mehta MP, Wefel JS, Tomé WA, Sun AY, Grecula J, Redmond KJ, Fogh S, Gaspar L  et al.  Hippocampal Avoidance During Prophylactic Cranial Irradiation for Patients With Small Cell Lung Cancer: Randomized Phase II/III Trial NRG-CC003.  J Clin Oncol  2025 Aug 11;:JCO2500221. doi:10.1200/JCO-25-00221
  33. Rock V, Ahluwalia MS, Anthony M, Arons D, Arzbaecher J, Dunbar E, Fraher C, Freund M, Gondi V, Khanuja S  et al.  Guiding principles for adult CNS tumor treatment programs.  Neurooncol Adv  2025;7(1):vdaf169. pii:vdaf169
  34. Liang J, Sun W, Zhou Y, Zhang P, Chen Y, Li X, He H, Liu X, Zhou S, Shen J  et al.  Study on the Central Neural Pathways Connecting the Brain and Peripheral Acupoints Using Neural Tracers.  CNS Neurosci Ther  2025 Aug;31(8):e70554. pii:e70554
  35. Hu W, Zhao C, Zheng W, Lin Y, Luo N, Liu H, Wang X, Qi X, Wang X, Li XN  et al.  Use of integrated spatial transcriptomics and histopathological analysis in adamantinomatous craniopharyngiomas to identify stromal cells as a new cellular source of leukemia inhibitory factor.  J Neurosurg  2025 Aug 01;:1-14. doi:10.3171/2025.4.JNS243146
  36. Tan PH, Ellis IO, Allison KH, Badve SS, Brogi E, Callagy G, Charafe-Jauffret E, Chen CJ, Chen YY, Collins LC  et al.  Malignant phyllodes tumours of the breast: the case for revising WHO's 'full house' diagnostic criteria.  Histopathology  2025 Aug;87(2):169-182. doi:10.1111/his.15455
  37. Smith HL, Duckett DJ, Mejia-Bautista M, Alshawa A, Jamshidi P, Castellani RJ, Lukas RV, Chandler JP, Jennings LJ, Santana-Santos L  et al.  IDH-wildtype astrocytoma with FH mutation, epigenetic similarity to IDH-mutant astrocytoma, and hypermethylation of CDKN2A arising in the brainstem.  J Neuropathol Exp Neurol  2025 Jul 22;. pii:nlaf086
  38. Izhar M, Al Gharyani M, Kattaa AH, Cardona JJ, Jain RP, Shaghaghian E, Hori YS, Lam FC, Abu Reesh D, Emrich SC  et al.  Overview of Preclinical and Clinical Trials of Nanoparticles for the Treatment of Brain Metastases.  Pharmaceutics  2025 Jul 11;17(7). pii:899
  39. Liu Y, Pang L, Khan F, Wu J, Zhou F, Horbinski C, Bao S, Yu JS, Lathia JD, Chen P  Glycoprotein NMB mediates bidirectional GSC-TAM interactions to promote tumor progression.  JCI Insight  2025 Jul 08;10(13). pii:e187684
  40. Vormittag-Nocito E, Duckett D, Castellani RJ, Ahrendsen JT, Lu X, Jennings LJ, Lukas RV, Magill ST, Santana-Santos L, Brat DJ  et al.  Meningiomas With Chromosomal Polysomies Reveal Nonrandom Gain of Chromosomes, Distinct Methylation Signature, and Lower Risk of Recurrence.  Mod Pathol  2025 Jul;38(7):100775. doi:10.1016/j.modpat.2025.100775
  41. Cheok SK, Ruzevick J, Briggs RG, Cote DJ, Shah I, Gomez D, Bove I, Feng JJ, Pangal DJ, Strickland BA  et al.  A contemporary, multiinstitutional analysis of transcription factor lineage in pituitary adenomas: comparative study of neuroimaging, histopathology, and clinical outcomes.  J Neurosurg  2025 Jul 01;143(1):146-154. doi:10.3171/2024.10.JNS24853
  42. Fernandopulle MS, Cotty-Fattal Z, Smith H, Mejia Bautista M, Ahrendsen JT, Jennings LJ, Santana-Santos L, Sukhanova M, Conway K, Primdahl D  et al.  Dual TERT promoter mutations in an oligodendroglioma, IDH-mutant, 1p/19q co-deleted.  J Neuropathol Exp Neurol  2025 Jul 01;84(7):658-660. doi:10.1093/jnen/nlae138
  43. Cheng SY, Yu X, Song X, Schäfer R, Meng Q, Tiek D, Wu R, He Q, Walker M, Yang R  et al.  An EGFR Co-Amplified and De Novo Long Noncoding RNA HELDR Promotes Glioblastoma Malignancy through KAT7-Driven Gene Programs.  Res Sq  2025 Jun 24;. pii:rs.3.rs-6456987
  44. Al-Mistarehi AH, Zaitoun KJ, Javed S, Xia Y, Hersh A, Ghaith AK, Weber-Levine C, Jiang K, Khan M, Mendelson B  et al.  Survival and Functional Outcomes Following Surgical Resection of Intramedullary Spinal Cord Tumors: A Series of 253 Patients over 22 Years.  Cancers (Basel)  2025 Jun 24;17(13). pii:2112
  45. Forrest N, Guggilla V, Bell A, Zelisko S, Federico EM, Power EA, Birch S, Nandoliya KR, Houskamp EJ, Tran S  et al.  Natural language processing algorithms identify wild-type isocitrate dehydrogenase gliomas in electronic health records.  Neurooncol Adv  2025;7(1):vdaf111. pii:vdaf111
  46. Sadagopan NS, Gomez M, Tripathi S, Billingham LK, DeLay SL, Cady MA, Congivaram HTS, Chia TY, Wan H, Wang S  et al.  NOTCH3 Drives Fatty Acid Oxidation and Ferroptosis Resistance in Aggressive Meningiomas.  Res Sq  2025 Jun 04;. pii:rs.3.rs-6779386
  47. Sperduto PW, Marqueen KE, Chang E, Li J, Davies MA, Ebner DK, Breen WG, Lamba N, Shih HA, Edwards D  et al.  Improved Survival and Prognostication in Melanoma Patients With Brain Metastases: An Update of the Melanoma Graded Prognostic Assessment.  J Clin Oncol  2025 Jun;43(16):1910-1919. doi:10.1200/JCO-24-01351
  48. Gruchala T, Lewis CW, Abplanalp K, Jayabalan P, Walunas TL, Johnson JL, Wainwright DA, Lukas RV, Spill G, Roy I  Predicting medical prognosis in patients with glioblastoma during inpatient rehabilitation using bed mobility function.  PM R  2025 May 19;. doi:10.1002/pmrj.13402
  49. Turunen JR, Kumthekar P, Ahmed AU  Beyond the brain: exploring the impact of animal models of leptomeningeal disease from solid tumors.  Acta Neuropathol Commun  2025 May 19;13(1):103. pii:103
  50. Izhar M, Lesniak MS  Role of Extracellular Vesicles in the Pathogenesis of Brain Metastasis.  J Extracell Biol  2025 May;4(5):e70051. pii:e70051
These are the publications from our team members that have been most recently indexed by PubMed. Visit PubMed to see more of our publications.

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