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Recent Publications

Browse recent studies from the Lou and Jean Malnati Brain Tumor Institute to learn more about our cutting-edge research.

  1. Evageliou N, Renfro LA, Geller J, Perlman E, Kalapurakal J, Paulino A, Dix D, Eklund MJ, Murphy AJ, Romao RLP  et al.  Prognostic impact of lymph node involvement and loss of heterozygosity of 1p or 16q in stage III favorable histology Wilms tumor: A report from Children's Oncology Group Studies AREN03B2 and AREN0532.  Cancer  2024 Mar 01;130(5):792-802. doi:10.1002/cncr.35084
  2. Peters KB, Templer J, Gerstner ER, Wychowski T, Storstein AM, Dixit K, Walbert T, Melnick K, Hrachova M, Partap S  et al.  Discontinuation of Antiseizure Medications in Patients With Brain Tumors.  Neurology  2024 Feb 27;102(4):e209163. doi:10.1212/WNL.0000000000209163
  3. Kudruk S, Forsyth CM, Dion MZ, Hedlund Orbeck JK, Luo J, Klein RS, Kim AH, Heimberger AB, Mirkin CA, Stegh AH  et al.  Multimodal neuro-nanotechnology: Challenging the existing paradigm in glioblastoma therapy.  Proc Natl Acad Sci U S A  2024 Feb 20;121(8):e2306973121. doi:10.1073/pnas.2306973121
  4. Tripathi S, Najem H, Dussold C, Pacheco S, Miska J, McCortney K, Steffens A, Walshon J, Winkowski D, Cloney M  et al.  Cancer-associated fibroblast-secreted collagen is associated with immune inhibitor receptor LAIR1 in gliomas.  J Clin Invest  2024 Feb 15;134(4). pii:e176613
  5. Arrillaga-Romany I, Gardner SL, Odia Y, Aguilera D, Allen JE, Batchelor T, Butowski N, Chen C, Cloughesy T, Cluster A  et al.  ONC201 (Dordaviprone) in Recurrent H3 K27M-Mutant Diffuse Midline Glioma.  J Clin Oncol  2024 Feb 09;:JCO2301134. doi:10.1200/JCO.23.01134
  6. Kim DR, Orr MJ, Yu X, Munshi HH, Wang A, Trudeau C, Kwong AJ, Cheng SY, Scheidt KA  Synthesis and Structural Optimization of ATG4B Inhibitors for the Attenuation of Autophagy in Glioblastoma.  ACS Med Chem Lett  2024 Feb 08;15(2):258-264. doi:10.1021/acsmedchemlett.3c00505
  7. Li J, Shih LK, Brat DJ  Integrated Proteogenomics Uncover Mechanisms of Glioblastoma Evolution, Pointing to Novel Therapeutic Targets.  Cancer Res  2024 Feb 08;. doi:10.1158/0008-5472.CAN-24-0452
  8. Moscona-Nissan A, Habashy KJ, Arrieta VA, Sonabend AM, Dmello C  Combining causal and correlative approaches to discover biomarkers of response to paclitaxel.  Oncotarget  2024 Feb 08;15:117-122. doi:10.18632/oncotarget.28549
  9. Collado J, Boland L, Ahrendsen JT, Miska J, Lee-Chang C  Understanding the glioblastoma tumor microenvironment: leveraging the extracellular matrix to increase immunotherapy efficacy.  Front Immunol  2024;15:1336476. pii:1336476
  10. Zhang S, Zhang T, Cao G, Zhou J, He Z, Li X, Ren Y, Liu T, Jiang X, Guo L  et al.  Species -Shared and -Unique Gyral Peaks on Human and Macaque Brains.  bioRxiv  2024 Feb 05;. pii:2023.07.26.550760
  11. Schwartz C, Rautalin I, Grauvogel J, Bissolo M, Masalha W, Steiert C, Schnell O, Beck J, Ebel F, Bervini D  et al.  Surgical Outcome of Patients With Supratentorial Meningiomas Aged 80 Years or Older-Retrospective International Multicenter Study.  Neurosurgery  2024 Feb 01;94(2):399-412. doi:10.1227/neu.0000000000002673
  12. Habashy KJ, Dmello C, Chen L, Arrieta VA, Kim KS, Gould A, Youngblood MW, Bouchoux G, Bell Burdett KB, Zhang H  et al.  Paclitaxel and Carboplatin in Combination with Low-Intensity Pulsed Ultrasound for Glioblastoma.  Clin Cancer Res  2024 Jan 31;. doi:10.1158/1078-0432.CCR-23-2367
  13. Cherng HR, Qu M, Zafari Z, Bentzen S, Armstrong TS, Gondi V, Brown PD, Mehta M, Mishra MV  Evaluating the sensitivity of EQ-5D-5L in patients with brain metastases: a secondary analysis of NRG CC001.  J Natl Cancer Inst  2024 Jan 27;. pii:djae020
  14. Zheng S, Rammohan N, Sita T, Teo PT, Wu Y, Lesniak M, Sachdev S, Thomas TO  GlioPredictor: a deep learning model for identification of high-risk adult IDH-mutant glioma towards adjuvant treatment planning.  Sci Rep  2024 Jan 25;14(1):2126. pii:2126
  15. Pandey S, Cholak ME, Yadali R, Sosman JA, Tetreault MP, Fang D, Pollack SM, Gnjatic S, Obeng RC, Lyerly HK  et al.  Immune Assessment Today: Optimizing and Standardizing Efforts to Monitor Immune Responses in Cancer and Beyond.  Cancers (Basel)  2024 Jan 23;16(3). pii:475
  16. Randall J, Sachdev S  A valuable glioblastoma prognostic maker driven by radiosensitivity.  Neuro Oncol  2024 Jan 23;. pii:noad266
  17. Khazanchi R, Nandoliya KR, Shahin MN, Rae AI, Chaliparambil RK, Bowden SG, Alwakeal A, Lopez Ramos CG, Stedelin B, Youngblood MW  et al.  Obesity and meningioma: a US population-based study paired with analysis of a multi-institutional cohort.  J Neurosurg  2024 Jan 19;:1-10. doi:10.3171/2023.11.JNS23732
  18. Paudel B, Jeong SY, Martinez CP, Rickman A, Haluck-Kangas A, Bartom ET, Fredriksen K, Affaneh A, Kessler JA, Mazzulli JR  et al.  Death Induced by Survival gene Elimination (DISE) correlates with neurotoxicity in Alzheimer's disease and aging.  Nat Commun  2024 Jan 18;15(1):264. pii:264
  19. Chia TY, Billingham LK, Boland L, Katz JL, Arrieta VA, Shireman J, Rosas AL, DeLay SL, Zillinger K, Geng Y  et al.  The CXCL16-CXCR6 axis in glioblastoma modulates T-cell activity in a spatiotemporal context.  Front Immunol  2023;14:1331287. pii:1331287
  20. Wang YZ, Castillon CCM, Gebis KK, Bartom ET, d'Azzo A, Contractor A, Savas JN  Notch receptor-ligand binding facilitates extracellular vesicle-mediated neuron-to-neuron communication.  Cell Rep  2024 Jan 17;43(2):113680. doi:10.1016/j.celrep.2024.113680
  21. Arrieta VA, Duerinck J, Burdett KB, Habashy KJ, Geens W, Gould A, Schwarze JK, Dmello C, Kim KS, Saganty R  et al.  ERK1/2 Phosphorylation Predicts Survival in Recurrent Glioblastoma Following Intracerebral and Adjuvant PD-1/CTLA-4 Immunotherapy: A REMARK-guided Analysis.  Clin Cancer Res  2024 Jan 17;30(2):379-388. doi:10.1158/1078-0432.CCR-23-1889
  22. Romay MC, Knutsen RH, Ma F, Mompeón A, Hernandez GE, Salvador J, Mirkov S, Batra A, Sullivan DP, Procissi D  et al.  Age-related loss of Notch3 underlies brain vascular contractility deficiencies, glymphatic dysfunction, and neurodegeneration in mice.  J Clin Invest  2024 Jan 16;134(2). pii:e166134
  23. Hou D, Wan H, Katz JL, Wang S, Castro BA, Vazquez-Cervantes GI, Arrieta VA, Dhiantravan S, Najem H, Rashidi A  et al.  Antigen-presenting B cells promote TCF-1+ PD1- stem-like CD8+ T-cell proliferation in glioblastoma.  Front Immunol  2023;14:1295218. pii:1295218
  24. Tripathi S, Nathan CL, Tate MC, Horbinski CM, Templer JW, Rosenow JM, Sita TL, James CD, Deneen B, Miller SD  et al.  The immune system and metabolic products in epilepsy and glioma-associated epilepsy: emerging therapeutic directions.  JCI Insight  2024 Jan 09;9(1). pii:e174753
  25. Bhutada I, Khambati F, Cheng SY, Tiek DM, Duckett D, Lawrence H, Vogelbaum MA, Mo Q, Chellappan SP, Padmanabhan J  CDK7 and CDK9 inhibition interferes with transcription, translation, and stemness, and induces cytotoxicity in GBM irrespective of temozolomide sensitivity.  Neuro Oncol  2024 Jan 05;26(1):70-84. doi:10.1093/neuonc/noad143
  26. Rashidi A, Billingham LK, Zolp A, Chia TY, Silvers C, Katz JL, Park CH, Delay S, Boland L, Geng Y  et al.  Myeloid cell-derived creatine in the hypoxic niche promotes glioblastoma growth.  Cell Metab  2024 Jan 02;36(1):62-77.e8. doi:10.1016/j.cmet.2023.11.013
  27. Pawlowski KD, Duffy JT, Gottschalk S, Balyasnikova IV  Cytokine Modification of Adoptive Chimeric Antigen Receptor Immunotherapy for Glioblastoma.  Cancers (Basel)  2023 Dec 15;15(24). pii:5852
  28. Fares J, Petrosyan E, Kanojia D, Dmello C, Cordero A, Duffy JT, Yeeravalli R, Sahani MH, Zhang P, Rashidi A  et al.  Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer and brain metastases.  J Clin Invest  2023 Dec 15;133(24). pii:e161142
  29. Cherng HR, Sun K, Bentzen S, Armstrong TS, Gondi V, Brown PD, Mehta M, Mishra MV  Evaluating the Heterogeneity of Hippocampal Avoidant Whole Brain Radiotherapy Treatment Effect: A Secondary Analysis of NRG CC001.  Neuro Oncol  2023 Dec 09;. pii:noad226
  30. Sadagopan NS, Nandoliya KR, Youngblood MW, Horbinski CM, Ahrendsen JT, Magill ST  A novel BRAF::PTPRN2 fusion in meningioma: a case report.  Acta Neuropathol Commun  2023 Dec 08;11(1):194. pii:194
  31. Chen WC, Choudhury A, Youngblood MW, Polley MC, Lucas CG, Mirchia K, Maas SLN, Suwala AK, Won M, Bayley JC  et al.  Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses.  Nat Med  2023 Dec;29(12):3067-3076. doi:10.1038/s41591-023-02586-z
  32. Primdahl D, Cohen-Nowak A, Kumthekar P  Novel approaches to treatment of leptomeningeal metastases.  Curr Opin Neurol  2023 Dec 01;36(6):592-602. doi:10.1097/WCO.0000000000001218
  33. Lukas RV, Horbinski C  Glioma Response to IDH Inhibition: Real-World Experience.  Clin Cancer Res  2023 Dec 01;29(23):4709-4710. doi:10.1158/1078-0432.CCR-23-2164
  34. Johnson M, Bell A, Lauing KL, Ladomersky E, Zhai L, Penco-Campillo M, Shah Y, Mauer E, Xiu J, Nicolaides T  et al.  Advanced Age in Humans and Mouse Models of Glioblastoma Show Decreased Survival from Extratumoral Influence.  Clin Cancer Res  2023 Dec 01;29(23):4973-4989. doi:10.1158/1078-0432.CCR-23-0834
  35. Wen PY, van den Bent M, Youssef G, Cloughesy TF, Ellingson BM, Weller M, Galanis E, Barboriak DP, de Groot J, Gilbert MR  et al.  RANO 2.0: Update to the Response Assessment in Neuro-Oncology Criteria for High- and Low-Grade Gliomas in Adults.  J Clin Oncol  2023 Nov 20;41(33):5187-5199. doi:10.1200/JCO.23.01059
  36. Lin NU, Kumthekar P, Sahebjam S, Ibrahim N, Fung A, Cheng A, Nicholas A, Sussell J, Pegram M  Pertuzumab plus high-dose trastuzumab for HER2-positive breast cancer with brain metastases: PATRICIA final efficacy data.  NPJ Breast Cancer  2023 Nov 17;9(1):94. pii:94
  37. Bartolomé RA, Martín-Regalado Á, Pintado-Berninches L, Robles J, Ramírez-González MÁ, Boukich I, Sanchez-Gómez P, Balyasnikova IV, Casal JI  Schnurri-3 drives tumor growth and invasion in cancer cells expressing interleukin-13 receptor alpha 2.  Cell Death Dis  2023 Nov 14;14(11):742. pii:742
  38. Benedetti DJ, Varela CR, Renfro LA, Tornwall B, Dix DB, Ehrlich PF, Glick RD, Kalapurakal J, Perlman E, Gratias E  et al.  Treatment of children with favorable histology Wilms tumor with extrapulmonary metastases: A report from the COG studies AREN0533 and AREN03B2 and NWTSG study NWTS-5.  Cancer  2023 Nov 07;. doi:10.1002/cncr.35099
  39. de Las Fuentes L, Schwander KL, Brown MR, Bentley AR, Winkler TW, Sung YJ, Munroe PB, Miller CL, Aschard H, Aslibekyan S  et al.  Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci.  Front Genet  2023;14:1235337. pii:1235337
  40. McCord M, Jamshidi P, Thirunavu V, Santana-Santos L, Vormittag-Nocito E, Dittman D, Parker S, Baczkowski J, Jennings L, Walshon J  et al.  Variant allelic frequencies of driver mutations can identify gliomas with potentially false-negative MGMT promoter methylation results.  Acta Neuropathol Commun  2023 Nov 02;11(1):175. pii:175
  41. Meredith DM, Cooley LD, Dubuc A, Morrissette J, Sussman RT, Nasrallah MP, Rathbun P, Yap KL, Wadhwani N, Bao L  et al.  ROS1 Alterations as a Potential Driver of Gliomas in Infant, Pediatric, and Adult Patients.  Mod Pathol  2023 Nov;36(11):100294. doi:10.1016/j.modpat.2023.100294
  42. Gondi V, Deshmukh S, Brown PD, Wefel JS, Armstrong TS, Tome WA, Gilbert MR, Konski A, Robinson CG, Bovi JA  et al.  Sustained Preservation of Cognition and Prevention of Patient-Reported Symptoms With Hippocampal Avoidance During Whole-Brain Radiation Therapy for Brain Metastases: Final Results of NRG Oncology CC001.  Int J Radiat Oncol Biol Phys  2023 Nov 01;117(3):571-580. doi:10.1016/j.ijrobp.2023.04.030
  43. Murnan KM, Horbinski C, Stegh AH  Redox Homeostasis and Beyond: The Role of Wild-Type Isocitrate Dehydrogenases for the Pathogenesis of Glioblastoma.  Antioxid Redox Signal  2023 Nov;39(13-15):923-941. doi:10.1089/ars.2023.0262
  44. Nandoliya KR, Winterhalter EJ, Karras CL, Khazanchi R, Youngblood MW, Texakalidis P, Chandler JP, Magill ST  Repeat Surgery for Vestibular Schwannomas: An Institutional Case Series.  J Neurol Surg Rep  2023 Oct;84(4):e140-e143. doi:10.1055/s-0043-1776124
  45. Youngblood MW, Erson-Omay Z, Li C, Najem H, Coșkun S, Tyrtova E, Montejo JD, Miyagishima DF, Barak T, Nishimura S  et al.  Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas.  Nat Commun  2023 Oct 07;14(1):6279. pii:6279
  46. Khan F, Lin Y, Ali H, Pang L, Dunterman M, Hsu WH, Frenis K, Rowe RG, Wainwright D, McCortney K  et al.  LDHA-regulated tumor-macrophage symbiosis promotes glioblastoma progression.  Res Sq  2023 Oct 05;.
  47. Pang L, Dunterman M, Guo S, Khan F, Liu Y, Taefi E, Bahrami A, Geula C, Hsu WH, Horbinski C  et al.  Kunitz-type protease inhibitor TFPI2 remodels stemness and immunosuppressive tumor microenvironment in glioblastoma.  Nat Immunol  2023 Oct;24(10):1654-1670. doi:10.1038/s41590-023-01605-y
  48. Perez Giraldo GS, Singer L, Cao T, Jamshidi P, Dixit K, Kontzialis M, Castellani R, Pytel P, Anadani N, Bevan CJ  et al.  Differential Diagnosis of Tumor-like Brain Lesions.  Neurol Clin Pract  2023 Oct;13(5):e200182. pii:e200182
  49. Singh K, Hotchkiss KM, Parney IF, De Groot J, Sahebjam S, Sanai N, Platten M, Galanis E, Lim M, Wen PY  et al.  Correcting the drug development paradigm for glioblastoma requires serial tissue sampling.  Nat Med  2023 Oct;29(10):2402-2405. doi:10.1038/s41591-023-02464-8
  50. Riviere-Cazaux C, Neth BJ, Hoplin MD, Wessel B, Miska J, Kizilbash SH, Burns TC  Glioma Metabolic Feedback In Situ: A First-In-Human Pharmacodynamic Trial of Difluoromethylornithine + AMXT-1501 Through High-Molecular Weight Microdialysis.  Neurosurgery  2023 Oct 01;93(4):932-938. doi:10.1227/neu.0000000000002511
These are the publications from our team members that have been most recently indexed by PubMed. Visit PubMed to see more of our publications.

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