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Recent Publications

Browse recent studies from the Lou and Jean Malnati Brain Tumor Institute to learn more about our cutting-edge research.

  1. Myneni S, Tang L, Akbari H, Mayne R, Kazemi F, Xiong R, Redmond KJ, Bilsky MH, Charest-Morin R, Tobert DG  et al.  The Spinal Chordoma Patient Reported Outcome Survey (spCPROS): a patient-centered, disease-specific tool for assessing quality of life in spinal chordoma patients.  J Neurooncol  2025 Nov;175(2):813-824. doi:10.1007/s11060-025-05181-z
  2. Lo SS, Halasz LM, Choi S, Kumthekar P, Wang TJC, Shu HK, Sloan AE, Olson JJ  Congress of Neurological Surgeons systematic review and evidence-based guidelines for the role of radiotherapy in the management of patients with diffuse low grade glioma in adults: update.  J Neurooncol  2025 Oct;175(1):21-33. doi:10.1007/s11060-025-05074-1
  3. Sadagopan NS, Gomez M, Tripathi S, Billingham LK, DeLay SL, Cady MA, Congivaram HTS, Chia TY, Wan H, Wang S  et al.  NOTCH3 drives fatty acid oxidation and ferroptosis resistance in aggressive meningiomas.  J Neurooncol  2025 Sep 09;. doi:10.1007/s11060-025-05208-5
  4. Kotecha R, Akdemir EY, Kutuk T, Ilgın C, Ahluwalia MS, Bi WL, Blakeley J, Dixit KS, Dunn IF, Galanis E  et al.  Benchmarking the efficacy of salvage systemic therapies for recurrent meningioma: A RANO group systematic review and meta-analysis to guide clinical trial design.  Neuro Oncol  2025 Sep 08;27(7):1670-1685. doi:10.1093/neuonc/noaf009
  5. Gui C, Wang JZ, Patil V, Landry AP, Singh O, Castelo-Branco P, Tabori U, Aldape K, Behling F, Barnholtz-Sloan JS  et al.  Analysis of TERT association with clinical outcome in meningiomas: a multi-institutional cohort study.  Lancet Oncol  2025 Sep;26(9):1191-1203. doi:10.1016/S1470-2045(25)00267-0
  6. Groff KJ, Patel RV, Feng Y, Ghosh HS, Millares Chavez MA, O'Brien J, Chen WC, Nitturi V, Save AV, Youngblood MW  et al.  The effect of TERT promoter mutation on predicting meningioma outcomes: a multi-institutional cohort analysis.  Lancet Oncol  2025 Sep;26(9):1178-1190. doi:10.1016/S1470-2045(25)00422-X
  7. Beck JA, Mazcko C, Belluco S, Bitar M, Brat D, Bush JW, Chkheidze R, Corps KN, Frank C, Giannini C  et al.  Comparative pathology boards facilitate the translation of knowledge between canine and human cancer patients.  Brain Pathol  2025 Sep;35(5):e70013. pii:e70013
  8. Benato A, Texakalidis P, Wolinsky JP  Reconstruction of posterior elements of the spine with femoral shaft allograft after spondylectomy for En bloc resection of tumor.  Eur Spine J  2025 Aug 14;. doi:10.1007/s00586-025-09141-z
  9. Feng Y, Haupt B, Huynh TT, Meshaw R, Martin-Regalado A, Thakur A, Duffy JT, Alzeer A, Siegel DA, Barnes A  et al.  Longitudinal Imaging Reveals Tumor Uptake and Prolonged Retention of Bispecific T Cell-Engaging Antibody in GBM via Passive and Active Mechanisms.  Clin Cancer Res  2025 Aug 14;31(16):3537-3549. doi:10.1158/1078-0432.CCR-24-4194
  10. Habashy KJ, Synold TW, Feng Y, Gomez C, Amidei C, Ward R, VanderMolen S, Zarrieneh A, Kim KS, Gomez M  et al.  Pharmacokinetic Analysis of Carboplatin and Fluorescein Brain Retention following Ultrasound-Based Blood-Brain Barrier Opening.  Clin Cancer Res  2025 Aug 14;31(16):3562-3570. doi:10.1158/1078-0432.CCR-25-0080
  11. Wen PY, Weller M, Lee EQ, Touat M, Khasraw M, Rahman R, Platten M, Lim M, Winkler F, Horbinski C  et al.  Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions.  Neuro Oncol  2025 Aug 13;. pii:noaf177
  12. Gondi V, Pugh SL, Mehta MP, Wefel JS, Tomé WA, Sun AY, Grecula J, Redmond KJ, Fogh S, Gaspar L  et al.  Hippocampal Avoidance During Prophylactic Cranial Irradiation for Patients With Small Cell Lung Cancer: Randomized Phase II/III Trial NRG-CC003.  J Clin Oncol  2025 Aug 11;:JCO2500221. doi:10.1200/JCO-25-00221
  13. Lassman AB, Polley MC, Iwamoto FM, Sloan AE, Wang TJC, Aldape KD, Wefel JS, Gondi V, Gutierrez AN, Manasawala MH  et al.  Dual Immune Check Point Blockade in MGMT-Unmethylated Newly Diagnosed Glioblastoma: NRG Oncology BN007, a Randomized Phase II/III Clinical Trial.  J Clin Oncol  2025 Aug 08;:JCO2500618. doi:10.1200/JCO-25-00618
  14. Liang J, Sun W, Zhou Y, Zhang P, Chen Y, Li X, He H, Liu X, Zhou S, Shen J  et al.  Study on the Central Neural Pathways Connecting the Brain and Peripheral Acupoints Using Neural Tracers.  CNS Neurosci Ther  2025 Aug;31(8):e70554. pii:e70554
  15. Hu W, Zhao C, Zheng W, Lin Y, Luo N, Liu H, Wang X, Qi X, Wang X, Li XN  et al.  Use of integrated spatial transcriptomics and histopathological analysis in adamantinomatous craniopharyngiomas to identify stromal cells as a new cellular source of leukemia inhibitory factor.  J Neurosurg  2025 Aug 01;:1-14. doi:10.3171/2025.4.JNS243146
  16. Tan PH, Ellis IO, Allison KH, Badve SS, Brogi E, Callagy G, Charafe-Jauffret E, Chen CJ, Chen YY, Collins LC  et al.  Malignant phyllodes tumours of the breast: the case for revising WHO's 'full house' diagnostic criteria.  Histopathology  2025 Aug;87(2):169-182. doi:10.1111/his.15455
  17. Smith HL, Duckett DJ, Mejia-Bautista M, Alshawa A, Jamshidi P, Castellani RJ, Lukas RV, Chandler JP, Jennings LJ, Santana-Santos L  et al.  IDH-wildtype astrocytoma with FH mutation, epigenetic similarity to IDH-mutant astrocytoma, and hypermethylation of CDKN2A arising in the brainstem.  J Neuropathol Exp Neurol  2025 Jul 22;. pii:nlaf086
  18. Nassiri F, Patil V, Yefet LS, Singh O, Liu J, Dang RMA, Yamaguchi TN, Daras M, Cloughesy TF, Colman H  et al.  Author Correction: Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial.  Nat Med  2025 Jul 21;. doi:10.1038/s41591-025-03895-1
  19. Izhar M, Al Gharyani M, Kattaa AH, Cardona JJ, Jain RP, Shaghaghian E, Hori YS, Lam FC, Abu Reesh D, Emrich SC  et al.  Overview of Preclinical and Clinical Trials of Nanoparticles for the Treatment of Brain Metastases.  Pharmaceutics  2025 Jul 11;17(7). pii:899
  20. Xia Y, Papali P, Al-Mistarehi AH, Ahmed AK, Hansen LJ, Meyer C, Gross J, Khan M, Winkle M, Bettegowda C  et al.  Long-term functional outcomes and their relationship to nerve root sacrifice after definitive surgery for sacrococcygeal chordoma.  J Neurosurg Spine  2025 Jul 11;:1-12. doi:10.3171/2025.3.SPINE241408
  21. Liu Y, Pang L, Khan F, Wu J, Zhou F, Horbinski C, Bao S, Yu JS, Lathia JD, Chen P  Glycoprotein NMB mediates bidirectional GSC-TAM interactions to promote tumor progression.  JCI Insight  2025 Jul 08;10(13). pii:e187684
  22. Corn BW, Paulus R, Gondi V, Mehta MP, Fogh S, Wefel JS, Videtic GM, Sun A, Yoon H, Heinzerling JH  et al.  "Hope" Drives Quality of Life in Patients With Brain Metastases, But, the "Hope Center" Remains Elusive: An Analysis of NRG-CC003.  Int J Radiat Oncol Biol Phys  2025 Jul 02;. pii:S0360-3016(25)04519-5
  23. Vormittag-Nocito E, Duckett D, Castellani RJ, Ahrendsen JT, Lu X, Jennings LJ, Lukas RV, Magill ST, Santana-Santos L, Brat DJ  et al.  Meningiomas With Chromosomal Polysomies Reveal Nonrandom Gain of Chromosomes, Distinct Methylation Signature, and Lower Risk of Recurrence.  Mod Pathol  2025 Jul;38(7):100775. doi:10.1016/j.modpat.2025.100775
  24. Cheok SK, Ruzevick J, Briggs RG, Cote DJ, Shah I, Gomez D, Bove I, Feng JJ, Pangal DJ, Strickland BA  et al.  A contemporary, multiinstitutional analysis of transcription factor lineage in pituitary adenomas: comparative study of neuroimaging, histopathology, and clinical outcomes.  J Neurosurg  2025 Jul 01;143(1):146-154. doi:10.3171/2024.10.JNS24853
  25. Fernandopulle MS, Cotty-Fattal Z, Smith H, Mejia Bautista M, Ahrendsen JT, Jennings LJ, Santana-Santos L, Sukhanova M, Conway K, Primdahl D  et al.  Dual TERT promoter mutations in an oligodendroglioma, IDH-mutant, 1p/19q co-deleted.  J Neuropathol Exp Neurol  2025 Jul 01;84(7):658-660. doi:10.1093/jnen/nlae138
  26. Cheng SY, Yu X, Song X, Schäfer R, Meng Q, Tiek D, Wu R, He Q, Walker M, Yang R  et al.  An EGFR Co-Amplified and De Novo Long Noncoding RNA HELDR Promotes Glioblastoma Malignancy through KAT7-Driven Gene Programs.  Res Sq  2025 Jun 24;. pii:rs.3.rs-6456987
  27. Al-Mistarehi AH, Zaitoun KJ, Javed S, Xia Y, Hersh A, Ghaith AK, Weber-Levine C, Jiang K, Khan M, Mendelson B  et al.  Survival and Functional Outcomes Following Surgical Resection of Intramedullary Spinal Cord Tumors: A Series of 253 Patients over 22 Years.  Cancers (Basel)  2025 Jun 24;17(13). pii:2112
  28. Forrest N, Guggilla V, Bell A, Zelisko S, Federico EM, Power EA, Birch S, Nandoliya KR, Houskamp EJ, Tran S  et al.  Natural language processing algorithms identify wild-type isocitrate dehydrogenase gliomas in electronic health records.  Neurooncol Adv  2025;7(1):vdaf111. pii:vdaf111
  29. Sadagopan NS, Gomez M, Tripathi S, Billingham LK, DeLay SL, Cady MA, Congivaram HTS, Chia TY, Wan H, Wang S  et al.  NOTCH3 Drives Fatty Acid Oxidation and Ferroptosis Resistance in Aggressive Meningiomas.  Res Sq  2025 Jun 04;. pii:rs.3.rs-6779386
  30. Sperduto PW, Marqueen KE, Chang E, Li J, Davies MA, Ebner DK, Breen WG, Lamba N, Shih HA, Edwards D  et al.  Improved Survival and Prognostication in Melanoma Patients With Brain Metastases: An Update of the Melanoma Graded Prognostic Assessment.  J Clin Oncol  2025 Jun;43(16):1910-1919. doi:10.1200/JCO-24-01351
  31. Gruchala T, Lewis CW, Abplanalp K, Jayabalan P, Walunas TL, Johnson JL, Wainwright DA, Lukas RV, Spill G, Roy I  Predicting medical prognosis in patients with glioblastoma during inpatient rehabilitation using bed mobility function.  PM R  2025 May 19;. doi:10.1002/pmrj.13402
  32. Turunen JR, Kumthekar P, Ahmed AU  Beyond the brain: exploring the impact of animal models of leptomeningeal disease from solid tumors.  Acta Neuropathol Commun  2025 May 19;13(1):103. pii:103
  33. Izhar M, Lesniak MS  Role of Extracellular Vesicles in the Pathogenesis of Brain Metastasis.  J Extracell Biol  2025 May;4(5):e70051. pii:e70051
  34. Pieters TA, Hersh AM, Elsamadicy AA, Pennington Z, Santangelo G, Najjar S, Hung B, Ber R, Atallah C, Efron J  et al.  Outcomes after en bloc resection with sacrectomy of advanced colorectal carcinomas that invade the sacrum: a multiinstitutional descriptive series.  J Neurosurg Spine  2025 May 01;42(5):598-604. doi:10.3171/2024.10.SPINE24391
  35. Tan S, Zhang Q, Zhan R, Luo S, Han Y, Yu B, Muss C, Pingault V, Marlin S, Delahaye A  et al.  Monoallelic loss-of-function variants in GSK3B lead to autism and developmental delay.  Mol Psychiatry  2025 May;30(5):1952-1965. doi:10.1038/s41380-024-02806-z
  36. Hou D, Wang S, Castro BA, Katz JL, Dapash M, Arrieta VA, Vazquez-Cervantes GI, Wan H, Billingham LK, Du R  et al.  Dual αVβ8 Integrin and PD-1 Blockade Overcomes TGFβ-Mediated B-Cell Suppression to Enhance Anti-Glioma Immunity.  Neuro Oncol  2025 Apr 22;. pii:noaf106
  37. Khalili BF, Dixit K, Kamson DO, Horbinski C, Przybyla DJ, Tate MC, Heimberger AB, Lukas RV, Templer JW  The excitatory milieu in glioma: mechanisms and therapeutic avenues.  Neuro Oncol  2025 Apr 18;. pii:noaf063
  38. Lee GY, Glicksman MA, Patel R, Malhotra S, Moelis N, Vanjani NN, Kumthekar P  Retrospective Review of Intra-Cerebrospinal Fluid (CSF) Drug Delivery in CNS Malignancies: Safety, Clinical Efficacy and Pharmacokinetic Profiles of Intracerebroventricular (ICV), Lumbar Intrathecal (LIT), and Intra-Cisterna Magna (ICM) Injections.  Cancers (Basel)  2025 Apr 09;17(8). pii:1263
  39. Seblani M, Zannikou M, Duffy JT, Joshi T, Levine RN, Thakur A, Puigdelloses-Vallcorba M, Horbinski CM, Miska J, Hambardzumyan D  et al.  IL13RA2-integrated genetically engineered mouse model allows for CAR T cells targeting pediatric high-grade gliomas.  Acta Neuropathol Commun  2025 Apr 02;13(1):69. pii:69
  40. Chia TY, Sadagopan NS, Miska J  Lipid peroxidation and immune activation: TRAF3's double-edged strategy against glioblastoma.  J Clin Invest  2025 Apr 01;135(7). pii:e190471
  41. Geurts M, Berchtold L, Koenig F, Nabors B, Reardon DA, Tonn JC, Stupp R, Gorlia T, Weller M, Preusser M  et al.  Temozolomide chemotherapy for patients with newly diagnosed glioblastoma in the CENTRIC EORTC 26071-22072 and CORE trials: Does time of administration matter?  Neurooncol Pract  2025 Apr;12(2):291-300. doi:10.1093/nop/npaf006
  42. Song X, Tiek D, Lu M, Yu X, Wu R, Walker M, He Q, Sisbarro D, Hu B, Cheng SY  A Single-Cell Atlas of RNA Alternative Splicing in the Glioma-Immune Ecosystem.  bioRxiv  2025 Mar 30;. pii:2025.03.26.645511
  43. Yu X, Song X, Tiek D, Wu R, Walker M, Horbinski C, Hu B, Cheng SY  Targeting PDGFRA-SHP2 Signaling Enhances Radiotherapy in IDH1-Mutant Glioma.  Neuro Oncol  2025 Mar 25;. pii:noaf086
  44. Seetharam D, Chandar J, Ramsoomair CK, Desgraves JF, Alvarado Medina A, Hudson AJ, Amidei A, Castro JR, Govindarajan V, Wang S  et al.  Activating antiviral immune responses potentiates immune checkpoint inhibition in glioblastoma models.  J Clin Invest  2025 Mar 17;135(6). pii:e183745
  45. McCord M, Sears T, Wang W, Chaliparambil R, An S, Sarkaria J, James CD, Ruggeri B, Gueble S, Bindra R  et al.  The novel DNA cross-linking agent KL-50 is active against patient-derived models of new and recurrent post-temozolomide mismatch repair-deficient glioblastoma.  Neuro Oncol  2025 Mar 07;27(3):644-651. doi:10.1093/neuonc/noae257
  46. Feng H, Hu B, Vuori K, Sarkaria JN, Furnari FB, Cavenee WK, Cheng S-  Correction: EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180.  Oncogene  2025 Mar;44(10):710-711. doi:10.1038/s41388-025-03290-7
  47. Wu Y, Gao X, Liu Z, Wang P, Wu Z, Li Y, Zhang T, Liu T, Liu T, Li X  Decoding cortical folding patterns in marmosets using machine learning and large language model.  Neuroimage  2025 Mar;308:121031. doi:10.1016/j.neuroimage.2025.121031
  48. Pedder JH, Sonabend AM, Cearns MD, Michael BD, Zakaria R, Heimberger AB, Jenkinson MD, Dickens D  Crossing the blood-brain barrier: emerging therapeutic strategies for neurological disease.  Lancet Neurol  2025 Mar;24(3):246-260. doi:10.1016/S1474-4422(24)00476-9
  49. Geller JI, Renfro LA, Grundy PE, Perlman EJ, Kalapurakal JA, Ehrlich PF, Biegel J, Huff V, Warwick AB, Paulino A  et al.  Rhabdoid Tumor of the Kidney and Soft Tissues: Results from National Wilms Tumor Study-5 and Children's Oncology Group Study AREN0321.  Pediatr Blood Cancer  2025 Mar;72(3):e31490. doi:10.1002/pbc.31490
  50. Morshed RA, Nguyen MP, Youngblood MW, Perlow HK, Lucas CG, Patel AJ, Palmer JD, Chandler JP, Theodosopoulos PV, Magill ST  et al.  Gene Expression Changes Associated With Recurrence After Gross Total Resection of Newly Diagnosed World Health Organization Grade 1 Meningioma.  Neurosurgery  2025 Mar 01;96(3):521-528. doi:10.1227/neu.0000000000003133
These are the publications from our team members that have been most recently indexed by PubMed. Visit PubMed to see more of our publications.

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