Research & Education

Recent Publications

Browse recent studies from the Lou and Jean Malnati Brain Tumor Institute to learn more about our cutting-edge research.

Gondi V, Deshmukh S, Brown PD, Wefel JS, Armstrong TS, Tome WA, Gilbert MR, Konski A, Robinson CG, Bovi JA et al. Sustained Preservation of Cognition and Prevention of Patient-Reported Symptoms With Hippocampal Avoidance During Whole-Brain Radiation Therapy for Brain Metastases: Final Results of NRG Oncology CC001. Int J Radiat Oncol Biol Phys 2023 Nov 01;117(3):571-580. doi:10.1016/j.ijrobp.2023.04.030
Pang L, Dunterman M, Guo S, Khan F, Liu Y, Taefi E, Bahrami A, Geula C, Hsu WH, Horbinski C et al. Kunitz-type protease inhibitor TFPI2 remodels stemness and immunosuppressive tumor microenvironment in glioblastoma. Nat Immunol 2023 Oct;24(10):1654-1670. doi:10.1038/s41590-023-01605-y
Perez Giraldo GS, Singer L, Cao T, Jamshidi P, Dixit K, Kontzialis M, Castellani R, Pytel P, Anadani N, Bevan CJ et al. Differential Diagnosis of Tumor-like Brain Lesions. Neurol Clin Pract 2023 Oct;13(5):e200182. pii:e200182
Riviere-Cazaux C, Neth BJ, Hoplin MD, Wessel B, Miska J, Kizilbash SH, Burns TC Glioma Metabolic Feedback In Situ: A First-In-Human Pharmacodynamic Trial of Difluoromethylornithine + AMXT-1501 Through High-Molecular Weight Microdialysis. Neurosurgery 2023 Oct 01;93(4):932-938. doi:10.1227/neu.0000000000002511
Wen PY, van den Bent M, Youssef G, Cloughesy TF, Ellingson BM, Weller M, Galanis E, Barboriak DP, de Groot J, Gilbert MR et al. RANO 2.0: Update to the Response Assessment in Neuro-Oncology Criteria for High- and Low-Grade Gliomas in Adults. J Clin Oncol 2023 Sep 29;:JCO2301059. doi:10.1200/JCO.23.01059
Lukas RV, Horbinski C Glioma Response to IDH Inhibition: Real-World Experience. Clin Cancer Res 2023 Sep 22;. doi:10.1158/1078-0432.CCR-23-2164
Johnson M, Bell A, Lauing KL, Ladomersky E, Zhai L, Penco-Campillo M, Shah Y, Mauer E, Xiu J, Nicolaides T et al. Advanced age in humans and mouse models of glioblastoma show decreased survival from extratumoral influence. Clin Cancer Res 2023 Sep 19;. doi:10.1158/1078-0432.CCR-23-0834
Sun MA, Yang R, Liu H, Wang W, Song X, Hu B, Reynolds N, Roso K, Chen LH, Greer PK et al. Repurposing Clemastine to Target Glioblastoma Cell Stemness. Cancers (Basel) 2023 Sep 18;15(18). pii:4619
Galat Y, Du Y, Perepitchka M, Li XN, Balyasnikova IV, Tse WT, Dambaeva S, Schneiderman S, Iannaccone PM, Becher O et al. In vitro vascular differentiation system efficiently produces natural killer cells for cancer immunotherapies. Oncoimmunology 2023;12(1):2240670. pii:2240670
Goenka A, Song X, Tiek D, Iglesia RP, Lu M, Zeng C, Horbinski C, Zhang W, Hu B, Cheng SY Oncogenic long noncoding RNA LINC02283 enhances PDGF receptor A-mediated signaling and drives glioblastoma tumorigenesis. Neuro Oncol 2023 Sep 05;25(9):1592-1604. doi:10.1093/neuonc/noad065
Wu SA, Jia DT, Schwartz M, Mulcahy M, Guo K, Tate MC, Sachdev S, Kostelecky N, Escobar DJ, Brat DJ et al. HER2+ esophageal carcinoma leptomeningeal metastases treated with intrathecal trastuzumab regimen. CNS Oncol 2023 Sep 01;12(3):CNS99. pii:CNS99
Karras CL, Texakalidis P, Thirunavu VM, Nandoliya KR, Khazanchi R, Byrne K, Chandler JP, Magill ST Outcomes following surgical resection of trigeminal schwannomas: a systematic review and meta-analysis. Neurosurg Rev 2023 Aug 30;46(1):215. doi:10.1007/s10143-023-02121-1
Zeng C, Song X, Zhang Z, Cai Q, Cai J, Horbinski C, Hu B, Cheng SY, Zhang W Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis. Acta Neuropathol Commun 2023 Aug 14;11(1):133. pii:133
Bhutada I, Khambati F, Cheng SY, Tiek DM, Duckett D, Lawrence H, Vogelbaum MA, Mo Q, Chellappan SP, Padmanabhan J CDK7 and CDK9 inhibition interferes with transcription, translation and stemness, and induces cytotoxicity in GBM irrespective of temozolomide sensitivity. Neuro Oncol 2023 Aug 08;. pii:noad143
Jo J, Diaz M, Horbinski C, Mackman N, Bagley S, Broekman M, Rak J, Perry J, Pabinger I, Key NS et al. Epidemiology, biology, and management of venous thromboembolism in gliomas: An interdisciplinary review. Neuro Oncol 2023 Aug 03;25(8):1381-1394. doi:10.1093/neuonc/noad059
Kros JM, Rushing E, Uwimana AL, Hernández-Laín A, Michotte A, Al-Hussaini M, Bielle F, Mawrin C, Marucci G, Tesileanu CMS et al. Mitotic count is prognostic in IDH mutant astrocytoma without homozygous deletion of CDKN2A/B. Results of consensus panel review of EORTC trial 26053 (CATNON) and EORTC trial 22033-26033. Neuro Oncol 2023 Aug 03;25(8):1443-1449. doi:10.1093/neuonc/noac282
Baskaran AB, Bhatia A, Kumthekar P, Boire A, Lukas RV Cerebrospinal fluid-administered therapies for leptomeningeal metastases from solid tumors. Future Oncol 2023 Aug;19(26):1801-1807. doi:10.2217/fon-2022-0926
Kim MM, Mehta MP, Smart DK, Steeg PS, Hong JA, Espey MG, Prasanna PG, Crandon L, Hodgdon C, Kozak N et al. National Cancer Institute Collaborative Workshop on Shaping the Landscape of Brain Metastases Research: challenges and recommended priorities. Lancet Oncol 2023 Aug;24(8):e344-e354. doi:10.1016/S1470-2045(23)00297-8
Chojak R, Fares J, Petrosyan E, Lesniak MS Cellular senescence in glioma. J Neurooncol 2023 Aug;164(1):11-29. doi:10.1007/s11060-023-04387-3
Nandoliya KR, Khazanchi R, Winterhalter EJ, Youngblood MW, Karras CL, Sonabend AM, Micco AG, Chandler JP, Magill ST Validating the VS-5 Score for Predicting Outcomes After Vestibular Schwannoma Resection in an Institutional Cohort. World Neurosurg 2023 Aug;176:e77-e82. doi:10.1016/j.wneu.2023.04.123
Meredith DM, Cooley LD, Dubuc A, Morrissette J, Sussman RT, Nasrallah MP, Rathbun P, Yap KL, Wadhwani N, Bao L et al. ROS1 Alterations as a Potential Driver of Gliomas in Infant, Pediatric, and Adult Patients. Mod Pathol 2023 Jul 31;36(11):100294. doi:10.1016/j.modpat.2023.100294
Singh K, Hotchkiss KM, Parney IF, De Groot J, Sahebjam S, Sanai N, Platten M, Galanis E, Lim M, Wen PY et al. Correcting the drug development paradigm for glioblastoma requires serial tissue sampling. Nat Med 2023 Jul 24;. doi:10.1038/s41591-023-02464-8
Sooreshjani M, Tripathi S, Dussold C, Najem H, de Groot J, Lukas RV, Heimberger AB The Use of Targeted Cytokines as Cancer Therapeutics in Glioblastoma. Cancers (Basel) 2023 Jul 23;15(14). pii:3739
Wahl CB, Chen J, Zhang H, Liu W, Zhang S, Wu J, Mirkin CA, Dravid VP, Apley DW, Chen W Automated Crystal System Identification from Four-dimensional Scanning Transmission Electron Microscopy Data Using Brain-inspired Artificial Intelligence. Microsc Microanal 2023 Jul 22;29(Supplement_1):1883-1884. doi:10.1093/micmic/ozad067.972
Budhiraja S, Najem H, Tripathi S, Wadhawani NR, Horbinski C, McCord M, Lenzen AC, Heimberger AB, DeCuypere M Immunobiology and Cytokine Modulation of the Pediatric Brain Tumor Microenvironment: A Scoping Review. Cancers (Basel) 2023 Jul 18;15(14). pii:3655
Wang K, Sun C, Dumčius P, Zhang H, Liao H, Wu Z, Tian L, Peng W, Fu Y, Wei J et al. Open source board based acoustofluidic transwells for reversible disruption of the blood-brain barrier for therapeutic delivery. Biomater Res 2023 Jul 15;27(1):69. pii:69
Poppe MM, Tai A, Li XA, Miften M, Olch A, Marks LB, Qureshi BM, Spunt SL, Shnorhavorian M, Nelson G et al. Kidney Disease in Childhood Cancer Survivors Treated With Radiation Therapy: A Comprehensive PENTEC Genitourinary Review. Int J Radiat Oncol Biol Phys 2023 Jul 14;. pii:S0360-3016(23)00197-9
Brastianos PK, Twohy E, Geyer S, Gerstner ER, Kaufmann TJ, Tabrizi S, Kabat B, Thierauf J, Ruff MW, Bota DA et al. BRAF-MEK Inhibition in Newly Diagnosed Papillary Craniopharyngiomas. N Engl J Med 2023 Jul 13;389(2):118-126. doi:10.1056/NEJMoa2213329
Alban TJ, Grabowski MM, Otvos B, Bayik D, Wang W, Zalavadia A, Makarov V, Troike K, McGraw M, Rabljenovic A et al. The MIF promoter SNP rs755622 is associated with immune activation in glioblastoma. JCI Insight 2023 Jul 10;8(13). pii:e160024
Zhang H, Du Y, Qi L, Xiao S, Braun FK, Kogiso M, Huang Y, Huang F, Abdallah A, Suarez M et al. Targeting GBM with an Oncolytic Picornavirus SVV-001 alone and in combination with fractionated Radiation in a Novel Panel of Orthotopic PDX models. J Transl Med 2023 Jul 06;21(1):444. pii:444
Alafandi A, van Garderen KA, Klein S, van der Voort SR, Rizopoulos D, Nabors L, Stupp R, Weller M, Gorlia T, Tonn JC et al. Association of pre-radiotherapy tumour burden and overall survival in newly diagnosed glioblastoma adjusted for MGMT promoter methylation status. Eur J Cancer 2023 Jul;188:122-130. doi:10.1016/j.ejca.2023.04.021
Perez Giraldo GS, Ali ST, Kang AK, Patel TR, Budhiraja S, Gaelen JI, Lank GK, Clark JR, Mukherjee S, Singer T et al. Neurologic Manifestations of Long COVID Differ Based on Acute COVID-19 Severity. Ann Neurol 2023 Jul;94(1):146-159. doi:10.1002/ana.26649
Wadhwani N, Nayak S, Wang Y, Hashizume R, Jie C, Mania-Farnell B, James CD, Xi G, Tomita T WDR82-Mediated H3K4me3 Is Associated with Tumor Proliferation and Therapeutic Efficacy in Pediatric High-Grade Gliomas. Cancers (Basel) 2023 Jun 30;15(13). pii:3429
Nandoliya KR, Sadagopan NS, Thirunavu V, Houskamp EJ, Karras CL, Chaliparambil RK, Sriram N, Jamshidi P, Raleigh DR, Lukas RV et al. Post-Surgical Prognosis of Patients with Pineoblastoma: A Systematic Review and Individual Patient Data Analysis with Trends over Time. Cancers (Basel) 2023 Jun 27;15(13). pii:3374
Galbraith K, Vasudevaraja V, Serrano J, Shen G, Tran I, Abdallat N, Wen M, Patel S, Movahed-Ezazi M, Faustin A et al. Clinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors-A prospective study and guidelines for clinical testing. Neurooncol Adv 2023;5(1):vdad076. pii:vdad076
Pawlowski KD, Duffy JT, Tiwari A, Zannikou M, Balyasnikova IV Bi-Specific Killer Cell Engager Enhances NK Cell Activity against Interleukin-13 Receptor Alpha-2 Positive Gliomas. Cells 2023 Jun 25;12(13). pii:1716
Bredel M, Espinosa L, Kim H, Scholtens DM, McElroy JP, Rajbhandari R, Meng W, Kollmeyer TM, Malta TM, Quezada MA et al. Haploinsufficiency of NFKBIA reshapes the epigenome antipodal to the IDH mutation and imparts disease fate in diffuse gliomas. Cell Rep Med 2023 Jun 20;4(6):101082. pii:101082
Murnan KM, Horbinski C, Stegh AH Redox Homeostasis and Beyond: The Role of Wild-Type Isocitrate Dehydrogenases for the Pathogenesis of Glioblastoma. Antioxid Redox Signal 2023 Jun 20;. doi:10.1089/ars.2023.0262
Wang Z, He M, Lv Y, Ge E, Zhang S, Qiang N, Liu T, Zhang F, Li X, Ge B Accurate corresponding fiber tract segmentation via FiberGeoMap learner with application to autism. Cereb Cortex 2023 Jun 20;33(13):8405-8420. doi:10.1093/cercor/bhad125
Knowles T, Huang T, Qi J, An S, Burket N, Cooper S, Nazarian J, Saratsis AM LIN28B and Let-7 in Diffuse Midline Glioma: A Review. Cancers (Basel) 2023 Jun 19;15(12). pii:3241
Drumm MR, Wang W, Sears TK, Bell-Burdett K, Javier R, Cotton KY, Webb B, Byrne K, Unruh D, Thirunavu V et al. Postoperative risk of IDH-mutant glioma-associated seizures and their potential management with IDH-mutant inhibitors. J Clin Invest 2023 Jun 15;133(12). pii:e168035
Baskaran AB, Buerki RA, Khan OH, Gondi V, Stupp R, Lukas RV, Villaflor VM Building Team Medicine in the Management of CNS Metastases. J Clin Med 2023 Jun 07;12(12). pii:3901
Nassiri F, Patil V, Yefet LS, Singh O, Liu J, Dang RMA, Yamaguchi TN, Daras M, Cloughesy TF, Colman H et al. Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial. Nat Med 2023 Jun;29(6):1370-1378. doi:10.1038/s41591-023-02347-y
Logun M, Colonna MB, Mueller KP, Ventarapragada D, Rodier R, Tondepu C, Piscopo NJ, Das A, Chvatal S, Hayes HB et al. Label-free in vitro assays predict the potency of anti-disialoganglioside chimeric antigen receptor T-cell products. Cytotherapy 2023 Jun;25(6):670-682. doi:10.1016/j.jcyt.2023.01.008
Chhabra AM, Rice SR, Holtzman A, Choi JI, Hasan S, Press RH, Chang J, Halasz L, Tsai HK, Wang CJ et al. Clinical outcomes and toxicities of 100 patients treated with proton therapy for chordoma on the proton collaborative group prospective registry. Radiother Oncol 2023 Jun;183:109551. doi:10.1016/j.radonc.2023.109551
Warrior S, Cohen-Nowak A, Kumthekar P Modern Management and Diagnostics in HER2+ Breast Cancer with CNS Metastasis. Cancers (Basel) 2023 May 25;15(11). pii:2908
Zhang S, Zhang T, He Z, Li X, Zhang L, Zhu D, Jiang X, Liu T, Han J, Guo L Gyral peaks and patterns in human brains. Cereb Cortex 2023 May 24;33(11):6708-6722. doi:10.1093/cercor/bhac537
Perrault EN, Shireman JM, Ali ES, Lin P, Preddy I, Park C, Budhiraja S, Baisiwala S, Dixit K, James CD et al. Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production. Sci Adv 2023 May 19;9(20):eade7236. pii:eade7236
Zhang Y, Nguyen CC, Zhang NT, Fink NS, John JD, Venkatesh OG, Roe JD, Hoffman SC, Lesniak MS, Wolinsky JP et al. Neurological applications of belzutifan in von Hippel-Lindau disease. Neuro Oncol 2023 May 04;25(5):827-838. doi:10.1093/neuonc/noac234
Sonabend AM, Gould A, Amidei C, Ward R, Schmidt KA, Zhang DY, Gomez C, Bebawy JF, Liu BP, Bouchoux G et al. Repeated blood-brain barrier opening with an implantable ultrasound device for delivery of albumin-bound paclitaxel in patients with recurrent glioblastoma: a phase 1 trial. Lancet Oncol 2023 May;24(5):509-522. doi:10.1016/S1470-2045(23)00112-2

These are the publications from our team members that have been most recently indexed by PubMed. Visit PubMed to see more of our publications.