The Keck Biophysics Facility offers access to a collection of advanced instruments for integrated studies of the structure, dynamics and interactions of biological and synthetic macro-molecules. The Keck Facility provides research groups at Northwestern with state of the art equipment, outstanding services, specialized training and technical expertise.
- Circular Dichroism Spectrometer (J-815)
- Fluorescence Polarization Instrument (BEACON 2000)
- Photon -Counting Fluorescence Spectrometer (ISS PC1)
- Differential Scanning Calorimeter (VP-DSC)
- Isothermal Titration Calorimeter (ITC200)
- Surface Plasmon Resonance(Reichert 4SPR)
- HPLC (Agilent 1100)
- Size Exclusion Chromatography with Light Scattering Detectors (SEC-MALS-QELS)
- Dynamic Light Scattering Instrument (BI-9000/BI-200)
- Gel Imaging System
- Phosphoimager/Fluoroimager Scanner (Typhoon 9400)
- UV/Vis/NIR Spectrophotometer with Integrating Sphere (PE Lambda 1050)
- Fluorescence Plate Reader (Gemini EM)
- NanoSight Instrument for Nanoparticle Tracking Analysis (NanoSight LM10HS)
- NanoDrop Fluorimeter
- For Registered Users:
- Assistance with experimental design, sample preparation and data analysis
- Technical expertise, written manuals, guidelines and application notes
- Staff -service options available on most instruments
- Advanced services including:
- Protein quality control (solubility, oligomeric state, secondary, tertiary structure assessment)
- Secondary Biophysical Screening for protein-ligand interactions (hit confirmation, target validation, along with detailed kinetic and thermodynamic characterization of the protein-ligand interactions)
- For Prospective Users:
- Consultation and assistance
- Support letters for grant applications and research proposals
- Tours and presentations of the facility for faculty or postdoctoral candidates
All manuscripts and grants presenting work supported by this core should include the following acknowledgement:
"This work was supported by the Northwestern University Keck Biophysics Facility and a Cancer Center Support Grant (NCI CA060553)."
The Keck Biophysics Facility is located on the Evanston Campus, in Cook Hall, Rooms 4106 and 4118S.
The office is located in Hogan Hall, 2-100.
All instruments are accessible to trained users on a 24/7 basis.