Northwestern University Feinberg School of Medicine
Research

Center for Translational Imaging

Mission

The mission of the Center for Translational Imaging (CTI) is three-fold:

  1. To provide access to world-class translational imaging capabilities that promote the pre-clinical and clinical research efforts of both NU investigators and our regional academic and industrial partners.
  2. To catalyze the development of innovative new imaging technologies for broad-scale interrogation of disease processes, guidance of therapeutic interventions, and the study human physiology and function.
  3. To provide unique educational opportunities thus fostering efficient, effective utilization of these valuable resources while training the next generation clinicians, biomedical scientists and engineers.

Equipment and Services

Cardiovascular Imaging

  1. Two state-of-the-art MR-systems dedicated to cardiovascular MRI research (Siemens 64-channel 1.5T Area System and Siemens 48-channel 3T Skyra)
  2. State-of-the-art whole-body Siemens 1.5-Tesla Area MRI scanner (Siemens Medical Solutions, Erlangen, Germany), 70 cm open bore design with 64 channels; XQ gradients (45 mT/m @ 200 T/m/s) which offers advanced features such as multi-channel technology and DOT engines not yet released to other systems. The 1.5T scanner has physiological monitoring equipment and a power injector.
  3. State-of-the-art whole-body Siemens 3.0 Tesla Skyra MRI scanner (Siemens Medical Solutions, Erlangen, Germany), 70 cm open bore design with 48 channels; XQ gradients (45 mT/m @ 200 T/m/s). The Magnetom 3T Skyra is the world's first 70cm Tim+Dot 3 Tesla MR system and sets a new standard for efficiency, ease of use, and the ability to enhance productivity.
  4. The Siemens Powermobile C-ARM Angiographic System is fully equipped for any x-ray angiographic study. It is capable of fluoroscopic and digital subtraction angiographic studies.

Neuro Imaging

  1. The Siemens 3T TIM Trio whole body magnet is fully equipped for any cardiac or neuro-imaging study. The TIM technology allows the use of 102 different coils on 32 independent receiver channels. We have three dedicated head coils (8, 12 and 32 channels), a neck coil, full spine coil in eight segments, a body array coil, 8 channel knee coil, and a breast coil. Support equipment includes full physiologic monitoring equipment (BP, HR, SAO2, ETCO2), IR eye tracker, equipment to deliver audio/visual stimuli for functional neuro-imaging experiments, an MRI compatible 64 channel EEG system, access to the magnet room via a patch panel for experimental devices, power injectors, full array of cushions and pads for positioning, and a filtered access panel for additional equipment.
  2. A sister 3T TIM Trio MRI system was installed in 2010. In 2015 this magnet was upgraded to the Siemens 3T Prisma platform, which is the latest technology from Siemens. This newest scanner has twice the gradient strength of the Trio system (80 mT/m) with modern day electronics. It is equipped with a 20 channel head coil and 64 channel head/neck coil. This new platform permits multiband simultaneous slice excitation to accelerate image acquisition rates. Support equipment for the Prisma scanner includes full physiologic monitoring equipment (BP, HR, SAO2, ETCO2), IR eye tracker, and equipment to necessary to deliver audio/visual stimuli for functional neuro-imaging experiments.
  3. The MRI simulator or “mock scanner” suite is available to investigators to acclimate research subjects, prepare experimental paradigms, and train research staff for actual MRI studies. The mock scanner simulates the real MRI scanner; offering physical, audio and visual duplication of our actual Siemens 3T Tim Trio scanner.  
  4. The Nexstim Navigated Brain Stimulation System for transcranial magnetic stimulation, allows for neuro-navigated stimulation of the cortex. This system integrates MRI images so visualization of the brain allows for pin point accuracy while stimulating. The system has an integrated EMG and is the non-invasive leap forward from surgical neuronavigation.

Small Animal Imaging

The Small Animal Imaging Division of the Center for Translational imaging (CTI) is equipped with state of the art equipment for translational/preclinical imaging of different disease models and different laboratory animal species (mice, rat and rabbit).

The following instruments are available to Northwestern investigators in the downtown campus (LC Olson Pavilion) via direct tunnel access to the Lurie Vivarium:

  1. Bruker Siemens Clinscan 7T MRI
    http://www.bruker.com/products/mr/preclinical-mri/clinscan/overview.html
  2. Mediso NanoScan PET/CT
    http://www.mediso.com/products.php?fid=2,11&pid=86

Design and development of custom imaging experiments can be integrated into any research project with the technical and scientific support of the facilities staff.

Single or Multimodality Imaging experiments in cardiology, oncology and neurology can be implemented to explore anatomy, function and metabolism.

Advanced animal handling and physiological monitoring of scanned subjects guarantees survival of test subjects and allows control over several parameters.

Advanced image processing software and services are also available upon request using commercial and non-commercial software.

Acknowledgements

All manuscripts and grants presenting work supported by this core should include the following acknowledgement:

"This work was supported by the Center for Translational Imaging at Northwestern University."

CTI

CTI Home Page

Contacts

Andrew Larson, PhD  
Director
(312) 926-3499


Cardiovascular Imaging

Michael Markl, PhD  
Director of Cardiovascular Imaging

Neuro Imaging

Todd Parrish, PhD  
Director of Neuro Imaging

Jennie Chen, PhD  
Research Manager

Small Animal Imaging

Daniel Procissi, PhD  
Director of Small Animal Imaging

Sol Misener 
Research Technologist


Location

Olson Pavilion
710 N. Fairbanks
- Lower Concourse
Chicago, IL 60611