The eukaryotic nucleus represents an amazing feat of cellular engineering with more than two meters of DNA packaged into each nucleus, large numbers of regulatory factors, a variety of structural proteins, and nuclear pores to regulate the entry and exit of proteins and gene products. Faculty are working to understand how this complex organelle is assembled and organized and how its activities are regulated.
Our research focuses on understanding:
- How structural proteins are assembled and how they regulate gene function
- How chromosome territories are organized and re-organized in response to developmental signals
- How specialized compartments of the nucleus function to process RNA
Labs in this Research Area
Studying the intermediate filament (IF) system in fibroblasts, epithelial cells and nerve cells through biochemical, morphological, immunological, cell physiological and molecular techniques.
Seeking to understand the nature and function of a unique nuclear structure, the perinucleolar compartment (PNC), and its relationship with the malignant phenotype
Looking to describe and probe the role of nuclear organization in stem cell maintenance and differentiation