Cells are exposed to a wide range of physical forces, including pressure, gravity, shear stress and tension. The field of mechanotransduction aims to understand how do cells sense these forces and translate them into biochemical and biological responses.
Our research focuses on understanding:
- How does the cytoskeleton contribute to mechanosensing and mechanotransduction?
- What are the biochemical sensors for shear stress forces?
- How do physical forces change gene expression and biological responses?
Robert Goldman Lab
Our lab investigates the structure and function of intermediate filaments (IF), a major cytoskeletal component that plays a critical role in providing structural and mechanical support to the cell.
Luisa Iruela-Arispe Lab
We focus on elucidating the molecular mechanisms that regulate vascular morphogenesis during development and in disease.