Meeting Schedule Overview

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• Day 1 | Monday, May 11
• Day 2 | Tuesday, May 12
• Day 3 | Wednesday, May 13

Day 1: Monday, May 11 | 1:00 p.m. - 6:30 p.m.

1:00 p.m. - 2:00 p.m. | Check-In - Simpson Querrey Auditorium

2:00 p.m. - 2:15 p.m. | Welcoming Remarks and Introduction by Rich D'Aquila

2:15 p.m. - 3:15 p.m. | Session 1: Viral Microenvironments, Molecular Mimicry, and the Reservoir of Persistence

Chairs: Rich D’Aquila, Michael McRaven

• 2:15 p.m. – 2:45 p.m. | Thomas Hope: A Unified Field Theory for HIV/SIV: SIV infection-induced cellular stress drives the formation of a unique viral microenvironment that functions as a sanctuary, facilitating persistence
• 2:45 p.m. – 3:15 p.m. | Kathleen Boris-Lawrie: Thriving under stress: HIV-1 adaption of specialized translation from hosts

3:15 p.m. - 4:45 p.m. | Session 2: Mucosal Immunity and HIV Target Cells in the Anogenital Tract

Chairs: Florian Hladik, S. Abigal Smith

• 3:15 p.m. – 3:45 p.m. | Rupert Kaul: Impact of sex on genital immunology and microbiota
• 3:45 p.m. – 4:15 p.m. | Andrew Harman: Defining the role of human anogenital APCs in HIV transmission
• 4:15 p.m. – 4:45 p.m. | Discussion

4:45 – 5:15 p.m. | Break

5:15 p.m. - 6:30 p.m. | Session 3: Antibody Function and Engineering in Mucosal HIV Immunity

Chairs: Jeff Schneider, Amit Sharma

• 5:15 p.m. – 5:45 p.m. | Francois Villinger: Mucosally targeted immune defenses to HIV infection
• 5:45 – 6:00 p.m. | Katelyn Freebern: Glycoengineering anti-HIV antibodies enhances accumulation in gastrointestinal mucosal tissues antibodies
• 6:00 p.m. – 6:15 p.m. | Claudia Stroupe: Fc-engineering alters in vivo trafficking and pharmacokinetics of VRC07-523LS
• 6:15 – 6:30 p.m. | Discussion

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Day 2: Tuesday, May 12 | 9:00 a.m. - 5:00 p.m.

8:00 a.m. - 9:00 a.m. | Breakfast/Check-In - Simpson Querrey Auditorium

9:00 a.m. - 11:30 a.m. | Session 4: Early Determinants of HIV Infection and Control

Chairs: Yanique Thomas, Francois Villinger

• 9:00 a.m. – 9:30 a.m. | Sunnie Yoh: Pathway-selective control of cGAS-STING signaling during HIV-1 infection
• 9:30 a.m. - 10:00 a.m. | Donald Sodora: Acute transient ART lowers SIV set point viral load in blood and tissues and preserves lymph node architecture

10:00 a.m. - 10:15 a.m. | Break

• 10:15 a.m. - 10:30 a.m. | Serena del Banco: A self-amplifying RNA vaccine induces HIV-specific systemic and mucosal immune responses in mice and nonhuman primates
• 10:30 a.m. – 10:45 a.m. | Shivali Vashisht: Interrogation of mucosal HIV vaccine responses using rectal proteomic and metagenomic profiling
• 10:45 – 11:00 a.m. | Ryan Moriarty: Generation of a vervet-derived SHIV to model mucosal HIV transmission in natural hosts
• 11:00 a.m. - 11:30 a.m. | Discussion

11:30 a.m. - 1:30 p.m. | Lunch and Networking - Lurie Ryan Family Atrium

1:30 p.m. - 1:45 p.m. Gather for a group photo

1:45 p.m. - 3:00 p.m. | Session 5: Hormonal and Device-Based Modulation of Mucosal Immunity

Chairs: Ann Marie Carias, Gilda Tachedjian

• 1:45 p.m. – 2:15 p.m. | S. Abigail Smith: Estradiol supplementation results in sex-specific patterns of inflammation after HIV challenge in the rectal explant model
• 2:15 p.m. – 2:30 p.m. | Kim Woodrow: Intrauterine mucosal systems compromising anti-infectives for steady-state accumulation to distal extrauterine targets
• 2:30 p.m. – 3:00 p.m. | Discussion

3:00 p.m. - 3:30 p.m. | Break 

3:30 p.m. - 4:30 p.m. | Session 6: Systems Immunology and Immune Reprogramming (Public Session)

Chair: Elena Martinelli

• 3:30 p.m. – 4:00 p.m. | Ujjwal Neogi: Reprogramming Immunometabolic Memory to Target Viral Persistence
• 4:00 p.m. – 4:15 p.m. | Iva Filipovic: Defining the Natural Killer Cell Landscape in Viral Infections Using Systems Immunology
• 4:15 p.m. – 4:30 p.m. | Discussion

4:30 p.m. – 5:00 p.m. | Poster Setup

5:00 p.m. - 7:00 p.m. | Poster Session/Reception - Lurie Ryan Family Atrium

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Day 3: Wednesday, May 13  

8:00 a.m. - 9:00 a.m. | Breakfast/Check-In - Simpson Querrey Auditorium

9:00 a.m. - 11:15 a.m. | Session 7: Persistence, Aging, and Microbiome Disruption

Chairs: Andrew Harmon, Supriya Mehta

• 9:00 a.m. - 9:30 a.m. | Mohamed Abdel-Mohsen: Senescence-mediated depletion of host-intrinsic prebiotic glycans promotes dysbiosis
• 9:30 a.m. – 10 a.m. | Florian Hladik: The contribution of ART to inflammagin

10:00 a.m. - 10:15 a.m. | Break

• 10:15 a.m. – 10:30 a.m. | Isabelle Clerc: Development of a viral immuno-capture assay to assess the cellular origin and genetic diversity of HIV-1 viruses
• 10:30 a.m.  – 10:45 a.m. | Kameron Walker: HIV-induced senescence of mast cells
• 10:45 a.m. – 11:15 a.m. | Discussion

11:30 a.m. - 1:45 p.m. | Lunch and Young Investigators Workshop 

Noon - 1:00 p.m. | HMSM attendees are welcome to attend CDB Experts in the Field – Marc Kirschner, PhD, Professor of Systems Biology, Harvard Medical School: "The size and shape of cells"

1:30 p.m. - 4:45 p.m. | Session 8: Microbiome and Mucosal Protection

Chairs: Alexandra Ortiz O’Sick, Thatiane Russo

• 1:30 p.m. - 1:45 P.M. | Babafemi Taiwo: ViiV Healthcare
• 1:45 p.m. – 2:15 p.m. | Gilda Tachedjian: Lactic acid selectively kills Lactobacillus iners and BV-associated bacteria to enable optimal L. crispatus colonisation to prevent HIV
• 2:15 p.m. – 2:45 p.m. | Supriya Mehta: Menstrual cups to prevent transition from optimal to not optimal vaginal microbiome community state types

2:45 p.m. - 3:15 p.m. | Break

• 3:15 p.m.– 3:45 p.m. | Adam Burgener: Studies of vaginal microbiome diversity and mucosal immunity underlying health disparities in HPV infection from Cleveland, Ohio
• 3:45 p.m. – 4:00 p.m. | Adit Chaudhary: Characterizing the bacterial surface profiling of menstrual cups and their association with user characteristics and vaginal microbiomes in an adolescent cohort from western Kenya
• 4:00 p.m. – 4:15 p.m. | Daniel Buffa: Utilizing unique human tissue samples to classify HIV target APCs within stratified squamous epithelium
• 4:15 p.m. – 4:45 p.m. | Discussion

4:45 p.m. - 5:30 p.m. | Session 9: Synthesis and Future Directions

Panel Participants: Thomas Hope*, Adam Burgener, Gilda Tachedjian, Florian Hladik, Francois Villinger

Chair*: Thomas Hope

• 4:45 p.m. – 5:30 p.m. | Panel discussion and audience Q&A: Key unanswered questions and future directions in HIV mucosal biology