Peptide Synthesis Core

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Mission

The mission of the Peptide Synthesis Core is to provide custom peptide synthesis, purification and mass spectrometry-based characterization services and technical support for members of the Center for Regenerative Nanomedicine (CRN), other Northwestern University researchers, and members of the Chicago and regional research community.

Services Offered

• Custom Peptide synthesis – automated synthesis of peptides at 0.05mmol-2mmol scales. Dye labeling and other modifications can also be carried out.
• Preparative HPLC – large scale purification of synthesized peptides based on chromatographic separation.
• Analytical HPLC – small scale purity determination of peptides and conjugates.
  • Mass spectrometry:Molecular weight determination of small molecules, peptides & oligonucleotides
  • LC/MS analysis for purity determination
• Lyophilization setup assistance

Equipment

• CEM Liberty Blue Microwave-Assisted Peptide Synthesizer
• CEM Liberty Prime 2.0 Microwave-Assisted peptide Synthesizer
• CEM MultiPep 2 Parallel Peptide Synthesizer
• Teledyne CombiFlash NextGen 300+ Flash Chromatography System
• Agilent 6230 Time-of-Flight (TOF) LC/MS
• Agilent 6510 Quadrupole Time-of-Flight (Q-ToF) LC/MS
• Shimadzu Prominence Preparative HPLC
• Waters Prep 150 Preparative HPLC
• Biotage V-10 Touch Solvent Evaporator