Research

The Center for Circadian and Sleep Medicine (CCSM) continues to initiate novel research studies, including basic and translational research, clinical trials, and technology development, that we believe will ultimately lead to improved health outcomes for our patients with circadian rhythm and sleep disorders. Our interdisciplinary teams are now capitalizing on seminal insights into how disturbed or inadequate sleep—independently or coupled with disturbed circadian timing—has been linked to an increased prevalence of disease and disorders including cardiovascular disease, diabetes, obesity, cancer, and mental illness.

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Recent Publications

Two Patients With Juvenile-Onset, Rapidly Progressive Amyotrophic Lateral Sclerosis Associated With an SOD1 Variant (p.Asp125Gly) With Incomplete Penetrance.

Ozlu C, Schwaede A, McGowan B, Zhang L, Finch M, Wolfe LF, Ajroud-Driss S, Franz CK, Kuntz N

Muscle Nerve 2026 Aug;74(2):457-462. doi:10.1002/mus.70314

Unexplained hypoventilation in adults: autoimmune encephalitis and beyond.

Lastra AC, Wolfe LF, Mokhlesi B

Eur Respir J 2026 Jun;67(6). pii:2600454

Initiation of first-generation antihistamines during pregnancy and gestational restless legs syndrome: a secondary analysis of the nuMoM2b cohort.

Kim M, Reid KJ, Friedlander R, Grobman WA, Wolf MS, Facco F, Silver RM, Greenland P, Yee LM, Zee PC

Am J Obstet Gynecol MFM 2026 Jun;8(6):101940. doi:10.1016/j.ajogmf.2026.101940

Depression severity and discordance between fatigue patient-reported outcomes in people with multiple sclerosis.

Queisi MM, Tomatsu S, Jacobs Z, Dada M, Wuppalapati SN, Posada F, Weller J, Wilken J, Hancock L, Penner I et al.

Mult Scler Relat Disord 2026 Jun;110:107192. doi:10.1016/j.msard.2026.107192

Circadian Rest-Activity Rhythms, Cognition, and Alzheimer Disease Dementia in Adults With Down Syndrome.

Chung PA, Fleming VL, Reid KJ, Plante DT, Hom CL, Ances BM, Handen BL, Christian BT, Head E, Mapstone M et al.

Neurology 2026 May 26;106(10):e214938. doi:10.1212/WNL.0000000000214938

Association of clinical, psychological, and lifestyle factors with disparities in sleep: the CARDIA sleep study.

Knutson KL, Reid KJ, Cai X, Alexandria SJ, Abbott SM, Chapagai S, Chirinos D, Thomas SJ, Lewis CE, Schreiner PJ et al.

Sleep 2026 Apr 16;49(4). pii:zsaf367

Association of Rest-Activity Rhythm and Sleep Regularity With Cardiometabolic Disease in the CARDIA Study.

Chapagai S, Schreiner PJ, Thomas SJ, Lewis CE, Alexandria SJ, Carnethon MR, Reid KJ, Knutson KL

J Am Heart Assoc 2026 Apr 07;15(7):e046839. pii:e046839

Understanding delayed sleep-wake phase disorder (DSWPD): Mechanisms, comorbidities, and evolving approaches to diagnosis and treatment.

Micic G, Reynolds AC, Phillips AJK, Zee P, Richardson C, Burgess HJ, Lack L, Catcheside P, Goldstein CA, Scott H et al...

Sleep Med Rev 2026 Apr;86:102240. doi:10.1016/j.smrv.2026.102240

Sleep-Aligned Extended Overnight Fasting Improves Nighttime and Daytime Cardiometabolic Function.

Grimaldi D, Reid KJ, Abbott SM, Knutson KL, Zee PC

Arterioscler Thromb Vasc Biol 2026 Apr;46(4):e323355. doi:10.1161/ATVBAHA.125.323355

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