Northwestern University Feinberg School of Medicine
Center for Healthcare Studies

Center for SQORE

Center for SQORE

Stroke is the number 1 cause of major adult disability in the United States. Though it is largely preventable, the incidence of stroke keeps climbing due to an aging population and rising rates of obesity, diabetes, and other risk factors. In addition, delivery of proven treatments to reverse the effects of stroke has been met with inefficient health systems and delays that limit their current use to only a minority (<10%) of patients. It is estimated that a properly functioning stroke system of care could reduce disability and death from stroke by 50% by ensuring acute therapies are provided promptly, that rehabilitation services are optimized, and preventive strategies are integrated into transitions of care from hospital to community.

The Northwestern Stroke Quality and Outcomes Research Enterprise (SQORE) harnesses the ingenuity of health service researchers at the Center of Healthcare Studies (CHS) including data scientists, engineers, and quality and implementation scientists along with the Northwestern Medicine Stroke Program leadership across the health system. We have 3 broad patient-oriented, clinically meaningful scientific aims to:

1. Develop and pilot novel decision aids, tools, and workflow interventions to improve delivery of time-sensitive treatments for stroke including tPA and mechanical embolectomy by increasing rate of treatment and reducing delays to treatment;

2. Utilize advanced data analytics, machine learning, and electronic infrastructure to reduce preventable complications after stroke, avoid medical errors in the emergency room and intensive care unit, and ensure optimal discharge planning for stroke patients to reduce readmissions after stroke; and

3. Apply real-time quantitative brain imaging analysis and prognostic modeling for patient-specific ("personalized") outcome prediction of recovery after stroke and targeted interventions, partnering with the Shirley Ryan Ability Lab (formerly Rehabilitation Institute of Chicago), to enhance maximum recovery, reduce disability, and increase return to productivity and employment after stroke.


SQORE accepts Northwestern Feinberg School of Medicine medical student applications as part of the Area of Scholarly Concentration (AOSC) program, whose mission is to train students to perform a highly mentored project which culminates with the writing of a thesis.  Areas of investigation include big data research, population and community health, global health, patient-reported outcomes, and quality improvement in stroke care. Medical students from the Feinberg School of Medicine are invited to apply. For more information on AOSC, please visit their website.

We also work with the Chicago Field Studies program to offer an intensive one-quarter academic internship program to Northwestern University undergraduates. Chicago Field Studies connects students with meaningful internships in parallel with a course to complement their field-based learning.  To learn more about Chicago Field Studies, please visit their website. SQORE also offers an annual Stroke Outcomes Research fellowship through the NIH/NINDS Stroke Trials Network. This program is aimed at developing skills that will enable candidates to complete for future grants and develop early academic careers in the field of stroke. For more information on the Stroke Outcomes Research Fellowship, please visit the Department of Neurology Fellowship website.

If you are interested in interning with our program, please contact Jillian Lux at

Our Projects

Learn more about our initiatives via the Department of Neurology site.


Shyam Prabhakaran, MD, MS

Core Faculty

Andrew Naidech, MD, MS

Marc Rosenman, MD

Scott Mendelson, PhD, MD

Eric Liotta, MD

Christopher T Richards, MD, MS

Ilana Ruff, MD

Jane Holl, MD

Data Analysts

Elissa Oh, MS

Ravi Garg, MS

Research Coordinators

Jillian Lux, MS, Research Project Manager

Erin Wymore, MS, CCRP, Research Project Coordinator

Kathryn Muldoon, MPH, Research Study Coordinator

Leena Thomas, MA, Research Study Coordinator