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Northwestern University Feinberg School of Medicine
Department of Biochemistry and Molecular Genetics

Recent Publications

  1. Gritsina G, Rath SK, Shi H, Chu Q, Xie W, Nguyen QTW, Senthil S, Myers TJ, Bilen MA, Fenton SE  et al.  AURKA inhibitor VIC-1911 induces mitotic defects and functional BRCAness, sensitizing prostate cancer to PARP inhibition.  JCI Insight  2026 May 08;11(9). pii:e196665
  2. Zhao Z, Shilatifard A  Enhancer and metabolic rewiring by KMT2C-COMPASS or KMT2D-COMPASS family loss in cancer creates druggable vulnerabilities.  Nat Rev Cancer  2026 Apr 24;. doi:10.1038/s41568-026-00919-x
  3. Fisher NP, Kanchustambham VL, Tsui EL, Lock C, Xu T, McDowell HB, Pla I, Saunders DC, Kafader JO, Laronda MM  et al.  Probing Proteoform Heterogeneity From Single Human Oocytes.  Mol Cell Proteomics  2026 Apr 09;25(5):101566. doi:10.1016/j.mcpro.2026.101566
  4. Chang HR, Boull C, Cotton CH, Eichenfield DZ, García-Romero MT, Hawryluk EB, Lara-Corrales I, Oza VS, Wan J, Weiss M  et al.  Building consensus in pediatric dermatology research.  J Invest Dermatol  2026 Apr 03;. pii:S0022-202X(26)00752-9
  5. Du Z, Alasady MJ, Mendillo ML, Li L  Transcriptomic analysis of Rnq1 loss and prionization reveals alterations in translation pathways and energy metabolism.  Sci Rep  2026 Apr 02;. doi:10.1038/s41598-026-46386-0
  6. Su P, Hollas MAR, Pla I, Rubakhin S, Butun FA, Greer JB, Early BP, Fellers RT, Caldwell MA, Sweedler JV  et al.  Proteoform profiling of endogenous single cells from rat hippocampus at scale.  Nat Biotechnol  2026 Apr;44(4):563-567. doi:10.1038/s41587-025-02669-x
  7. Brea L, Shi H, Keo V, Huang J, Peng L, Chu Q, Xie W, Xie Y, Senthil S, Breneman MT  et al.  FOXA1 loss drives basal/squamous de-differentiation of prostate cancer and induces an immunosuppressive tumor microenvironment.  Nat Commun  2026 Mar 28;. doi:10.1038/s41467-026-71121-8
  8. Vidal-Cruchez O, Ben-Sahra I  The oncogenic control of nucleotide synthesis.  Oncogenesis  2026 Mar 26;15(1). pii:17
  9. Fischietti M, Zannikou M, Beauchamp EM, Saleiro D, Baran AH, Hryhorysak BN, Magaña JNG, Fajardo EL, Blyth GT, Castro BA  et al.  Schlafen 5 is an intracellular immune checkpoint and controls IFN responses in pancreatic ductal adenocarcinoma.  JCI Insight  2026 Mar 09;11(5). pii:e190031
  10. Smith RS, Mendillo ML  Heat shock transcription factors in development and disease.  Dis Model Mech  2026 Mar 01;19(3). pii:dmm052700
  11. Bodner J, Vadlamani P, Lee AS, Helmin KA, Liu Q, Pratasenia AE, Horst MMA, Ravisankar S, Khurana S, Mendillo ML  et al.  Human CRAMP1 specifically promotes the expression of histone H1 genes.  EMBO Rep  2026 Mar;27(5):1122-1145. doi:10.1038/s44319-026-00704-9
  12. Lee AS, Fisher NP, Marunde MR, Su P, Khan LF, Ezell RJ, Gillespie ZB, Graham B, Taylor HF, Onuoha UC  et al.  Direct Readout of Multivalent Chromatin Reader-Nucleosome Interactions by Nucleosome Mass Spectrometry.  ACS Cent Sci  2026 Feb 25;12(2):208-221. doi:10.1021/acscentsci.5c00736
  13. Chen YH, Collette JR, Sampat K, Yonchev ID, Hawkins CE, Ponne C, Rosencrance CD, Eagen KP  NSD3 stabilizes nuclear compartmentalization and promotes megabase-scale chromatin interactions.  bioRxiv  2026 Feb 10;. pii:2026.02.07.704091
  14. Vidal-Cruchez O, Ben-Sahra I  DHODH turns cytosolic, yet cells keep growing.  Nat Metab  2026 Feb;8(2):290-292. doi:10.1038/s42255-026-01466-3
  15. Xie W, Chu Q, Brea L, Zeng G, Wang Y, Lu X, Zheng M, Ley CR, Lei Z, Shi H  et al.  EZH2 PROTACs outperform catalytic inhibitors in prostate cancer by targeting a methylation-independent function of PRC2.  Oncogene  2026 Feb;45(5):636-649. doi:10.1038/s41388-025-03662-z
  16. Zheng B, Qiu R, Gold S, Iwanaszko M, Aoi Y, Howard BC, Das M, Shilatifard A  BRD2 bridges TFIID and MOF-H4K16ac-containing nucleosomes to promote transcriptional initiation.  Mol Cell  2026 Jan 22;86(2):273-288.e6. doi:10.1016/j.molcel.2025.12.010
  17. Sanchez A, Pla I, Huang CF, Kanchustambham VL, Hollas MAR, Greer JB, Ladner DP, Peterson KN, Fisher TD, Su T  et al.  SPAP: Soluble Human Plasma Proteoform Analysis via Acetonitrile Precipitation and Top-Down Mass Spectrometry.  J Am Soc Mass Spectrom  2026 Jan 07;37(1):188-199. doi:10.1021/jasms.5c00289
  18. Fisher TD, Compton PD, Robey MT, Fellers RT, Durbin KR, Kelleher NL  Automated Enzymatic Deglycosylation of Monoclonal Antibody with the SampleStream Platform.  J Am Soc Mass Spectrom  2026 Jan 07;37(1):336-340. doi:10.1021/jasms.5c00242
  19. Beauchamp EM, Jain A, Clutter M, Nahotko D, Lopez Fajardo E, Vagadia PP, Dunne SF, Mina A, Fischietti M, Oku CV  et al.  Development of a SIN1 targeting inhibitor as a novel therapeutic approach for the treatment of malignancies.  Mol Cancer Ther  2025 Dec 22;. doi:10.1158/1535-7163.MCT-25-0298
  20. Huang CF, Su T, Flozak AS, Gottardi CJ, Kelleher NL  Intact Mass Profiling Reveals Phospho-Proteoforms of the Catenins (85-110 kDa) Regulated by Actomyosin Contractility.  Angew Chem Int Ed Engl  2025 Dec 22;64(52):e18593. pii:e18593
  21. Parast S, Wang S, Iwanaszko M, He Y, Olgun DG, Gold S, Zeidner JM, Aoi Y, Howard BC, Thakur WR  et al.  Defective RNA processing and ELOA-mediated transcriptional elongation in reversible cellular senescence suggest aging by transcription.  Mol Cell  2025 Dec 18;85(24):4545-4561.e8. doi:10.1016/j.molcel.2025.11.021
  22. Srivastava S, Samaniego-Castruita D, Srivastava S, Khurana S, Rehman J, Shukla V, Ben-Sahra I, Foltz DR  Rate-limiting enzymes in nucleotide metabolism synchronize nucleotide biosynthesis and chromatin formation.  Mol Cell  2025 Dec 18;85(24):4510-4525.e8. doi:10.1016/j.molcel.2025.11.009
  23. Yu J, Ramirez MA, Wang YZ, Edassery S, Shramuk M, Cheatham MA, Rutherford MA, Welty LJ, Savas JN  Heat-shock pathway activation by TRC051384 protects spiral ganglion neurons from noise-induced hearing loss.  bioRxiv  2025 Dec 11;. pii:2025.12.08.693048
  24. Lu X, Peng L, Chu Q, Ye S, Liu M, Hussain M, Bilen MA, Harik LR, Melamed J, Zhao JC  et al.  Targeting p300 and CBP abolishes HOXB13-loss-induced lipogenesis and tumor metastasis.  JCI Insight  2025 Nov 24;10(22). pii:e195743
  25. Nengroo MA, Klein AT, Carr HS, Vidal-Cruchez O, Sahu U, McGrail DJ, Sahni N, Thompson NB, Faull PA, Gao P  et al.  Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle.  Mol Cell  2025 Nov 20;85(22):4215-4228.e9. doi:10.1016/j.molcel.2025.10.002
  26. Monroe TO, Puckelwartz MJ, Pesce LL, Kearns SD, Page P, Ibrahim N, Weber ZT, Ugwor EI, Nóbrega MA, Kannankeril P  et al.  A combined genomic arrhythmia propensity score delineates cumulative risk.  Cell Rep Med  2025 Nov 18;6(11):102455. pii:102455
  27. Guillen Magaña JN, Zannikou M, Baran A, Small S, Schieber M, Schipma MJ, Bartom ET, Kocherginsky M, Saleiro D, Beauchamp EM  et al.  Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia.  Cancer Res Commun  2025 Nov 01;5(11):2012-2024. doi:10.1158/2767-9764.CRC-25-0283
  28. Skinner KA, Fisher TD, Lee A, Su T, Forte E, Sanchez A, Caldwell MA, Kelleher NL  Next-generation protein sequencing and individual ion mass spectrometry enable complementary analysis of interleukin-6.  Anal Bioanal Chem  2025 Nov;417(28):6291-6299. doi:10.1007/s00216-025-06120-7
  29. Choi J, Gordon A, Eresen A, Zhang Z, Borhani A, Bagci U, Lewandowski R, Kim DH  Current applications of radiomics in the assessment of tumor microenvironment of hepatocellular carcinoma.  Abdom Radiol (NY)  2025 Oct;50(10):4661-4675. doi:10.1007/s00261-025-04916-w
  30. Lu X, Keo V, Cheng I, Xie W, Gritsina G, Wang J, Lu L, Shiau CK, He Y, Jin Q  et al.  NKX2-1 drives neuroendocrine transdifferentiation of prostate cancer via epigenetic and 3D chromatin remodeling.  Nat Genet  2025 Aug;57(8):1966-1980. doi:10.1038/s41588-025-02265-4
  31. Wang X, Li Y, Lin Z, Pla I, Gajjela R, Mattamana BB, Joshi M, Liu Y, Wang H, Zun AB  et al.  Microtopography-induced changes in cell nucleus morphology enhance bone regeneration by modulating the cellular secretome.  Nat Commun  2025 Jul 11;16(1):6444. pii:6444
  32. Xu T, Su T, Soye BJD, Kandi S, Huang CF, Wilkins JT, Castellani RJ, Kafader JO, Patrie SM, Vassar R  et al.  The Proteoform Landscape of Tau from the Human Brain.  J Proteome Res  2025 Jun 06;24(6):2916-2925. doi:10.1021/acs.jproteome.5c00139
  33. Wang X, Grobe N, Franchin B, Levitsky J, Cravedi P, Kotanko P  Metabolomic and proteomic analyses of renal function after liver transplantation.  Front Transplant  2025;4:1572852. pii:1572852
  34. Ives AN, Jooß K, Melani RD, Fellers RT, Janetzko J, Kelleher NL  Capillary Zone Electrophoresis-Mass Spectrometry of Intact G Protein-Coupled Receptors Enables Proteoform Profiling.  Anal Chem  2025 Apr 08;97(13):7307-7316. doi:10.1021/acs.analchem.4c06994
  35. Li L, Zhou T, Lu Y, Chen J, Lei Y, Wu Q, Arnold J, Becich MJ, Bisyuk Y, Blecker S  et al.  Kidney Function Following COVID-19 in Children and Adolescents.  JAMA Netw Open  2025 Apr 01;8(4):e254129. pii:e254129
  36. Telenson AM, Hsieh RR, Cowen GJ, Sode EP, Kwon JM, Vo AH, Hadhazy M, Page PG, Rao NR, Pesce L  et al.  A novel, rapidly progressive ataxia due to a spontaneous Myo5a mutation in mice impairs transport proteins and alters mitochondria.  FASEB J  2025 Mar 15;39(5):e70423. doi:10.1096/fj.202402274R
  37. Zheng B, Iwanaszko M, Soliman SHA, Ishi Y, Gold S, Qiu R, Howard BC, Das M, Zhao Z, Hashizume R  et al.  Ectopic expression of testis-specific transcription elongation factor in driving cancer.  Sci Adv  2025 Mar 14;11(11):eads4200. pii:eads4200
  38. McNally EM, Spencer MJ  Genetic Medicine for Danon Disease.  N Engl J Med  2025 Mar 06;392(10):1028-1032. doi:10.1056/NEJMe2415793
  39. Nengroo MA, Klein AT, Carr HS, Vidal-Cruchez O, Sahu U, McGrail DJ, Sahni N, Gao P, Asara JM, Shah H  et al.  Succinate dehydrogenase activity supports de novo purine synthesis.  bioRxiv  2025 Mar 01;. pii:2025.02.26.640389
  40. Skinner KA, Fisher TD, Lee A, Su T, Forte E, Sanchez A, Caldwell MA, Kelleher NL  Next-Generation Protein Sequencing and individual ion mass spectrometry enable complementary analysis of interleukin-6.  bioRxiv  2025 Feb 08;. pii:2025.02.07.637157
  41. Wang X, Cheng L, Lu X, Jin H, Cui L, Guo Y, Guo J, Xu EY  Cross-species comparative single-cell transcriptomics highlights the molecular evolution and genetic basis of male infertility.  Cell Rep  2025 Jan 28;44(1):115118. doi:10.1016/j.celrep.2024.115118
  42. Aoi Y, Iravani L, Mroczek IC, Gold S, Howard BC, Shilatifard A  SPT5 regulates RNA polymerase II stability via Cullin 3-ARMC5 recognition.  Sci Adv  2025 Jan 24;11(4):eadt5885. pii:eadt5885
  43. Wang X, Li Y, Lin Z, Pla I, Gajjela R, Mattamana BB, Joshi M, Liu Y, Wang H, Zun AB  et al.  Micropillar-induced changes in cell nucleus morphology enhance bone regeneration by modulating the secretome.  Res Sq  2025 Jan 07;. pii:rs.3.rs-5530535
  44. Saleiro D, Wen JQ, Zannikou M, Lee B, Kosciuczuk EM, Nehlsen SD, Munshi A, Chen X, Oku CV, Hryhorysak B  et al.  Loss of Function Mouse Models Reveal a Novel Regulatory Function for ULK1 in Myeloproliferative Neoplasms.  Mol Cell Biol  2025;45(9):395-418. doi:10.1080/10985549.2025.2529837
  45. Goncharoff D, Du Z, Venkatesan S, Cho B, Zhao J, Alasady MJ, Huey D, Ma H, Rosenthal J, Turenitsa A  et al.  Investigating the Aggregation and Prionogenic Properties of Human Cancer-Related Proteins.  Mol Cell Biol  2025;45(4):154-168. doi:10.1080/10985549.2025.2481054
  46. McNally EM  A Multiple Hit Model for Genetic Susceptibility to Cardiomyopathy.  JACC Heart Fail  2025 Jan;13(1):149-153. doi:10.1016/j.jchf.2024.10.013
  47. Cenik BK, Aoi Y, Iwanaszko M, Howard BC, Morgan MA, Andersen GD, Bartom ET, Shilatifard A  TurboCas: A method for locus-specific labeling of genomic regions and isolating their associated protein interactome.  Mol Cell  2024 Dec 19;84(24):4929-4944.e8. doi:10.1016/j.molcel.2024.11.007
  48. McNally EM, Puckelwartz MJ, Nóbrega MA  The Past, the Present, and the Future of Genomic Therapies in Cardiovascular Disease.  J Am Heart Assoc  2024 Dec 03;13(23):e035987. pii:e035987
  49. Small SH, Perez RE, Beauchamp EM, Baran AH, Willis SD, Fischietti M, Schieber M, Kocherginsky M, Saleiro D, Platanias LC  Targeting SLFN11-regulated pathways restores chemotherapy sensitivity in AML.  Blood Neoplasia  2024 Dec;1(4):100037. pii:100037
  50. Zhang M, Stone S, Bajaj G, Patel M, Rydberg L  Integrating Disability Education into the Preclinical Neurology Curriculum.  Med Sci Educ  2024 Dec;34(6):1275-1277. doi:10.1007/s40670-024-02170-1

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