Recent Publications

Human CRAMP1 specifically promotes the expression of histone H1 genes.
Bodner J, et al. Among authors: foltz dr, mendillo ml.
EMBO Rep. 2026 Feb 9. doi: 10.1038/s44319-026-00704-9. Online ahead of print.
EZH2 PROTACs outperform catalytic inhibitors in prostate cancer by targeting a methylation-independent function of PRC2.
Xie W, et al. Among authors: yu j.
Oncogene. 2026 Feb;45(5):636-649. doi: 10.1038/s41388-025-03662-z. Epub 2026 Jan 7.
Schlafen 5 is an intracellular immune checkpoint and controls interferon responses in pancreatic ductal adenocarcinoma.
Fischietti M, et al. Among authors: platanias lc, bartom et.
JCI Insight. 2026 Jan 27:e190031. doi: 10.1172/jci.insight.190031. Online ahead of print.
BRD2 bridges TFIID and MOF-H4K16ac-containing nucleosomes to promote transcriptional initiation.
Zheng B, Qiu R, Gold S, Iwanaszko M, Aoi Y, Howard BC, Das M, Shilatifard A.
Mol Cell. 2026 Jan 22;86(2):273-288.e6. doi: 10.1016/j.molcel.2025.12.010. Epub 2025 Dec 31.
SPAP: Soluble Human Plasma Proteoform Analysis via Acetonitrile Precipitation and Top-Down Mass Spectrometry.
Sanchez A, et al. Among authors: kelleher nl.
J Am Soc Mass Spectrom. 2026 Jan 7;37(1):188-199. doi: 10.1021/jasms.5c00289. Epub 2025 Dec 18.
Automated Enzymatic Deglycosylation of Monoclonal Antibody with the SampleStream Platform.
Fisher TD, Compton PD, Robey MT, Fellers RT, Durbin KR, Kelleher NL.
J Am Soc Mass Spectrom. 2026 Jan 7;37(1):336-340. doi: 10.1021/jasms.5c00242. Epub 2025 Dec 8.
Development of a SIN1 targeting inhibitor as a novel therapeutic approach for the treatment of malignancies.
Beauchamp EM, et al. Among authors: goo ya, platanias lc.
Mol Cancer Ther. 2025 Dec 22:10.1158/1535-7163.MCT-25-0298. doi: 10.1158/1535-7163.MCT-25-0298. Online ahead of print.
Intact Mass Profiling Reveals Phospho-Proteoforms of the Catenins (85-110 kDa) Regulated by Actomyosin Contractility.
Huang CF, Su T, Flozak AS, Gottardi CJ, Kelleher NL.
Angew Chem Int Ed Engl. 2025 Dec 22;64(52):e18593. doi: 10.1002/anie.202518593. Epub 2025 Oct 29.
Defective RNA processing and ELOA-mediated transcriptional elongation in reversible cellular senescence suggest aging by transcription.
Parast S, Wang S, Iwanaszko M, He Y, Olgun DG, Gold S, Zeidner JM, Aoi Y, Howard BC, Thakur WR, Ramani V, Shilatifard A.
Mol Cell. 2025 Dec 18;85(24):4545-4561.e8. doi: 10.1016/j.molcel.2025.11.021.
Rate-limiting enzymes in nucleotide metabolism synchronize nucleotide biosynthesis and chromatin formation.
Srivastava S, Samaniego-Castruita D, Srivastava S, Khurana S, Rehman J, Shukla V, Ben-Sahra I, Foltz DR.
Mol Cell. 2025 Dec 18;85(24):4510-4525.e8. doi: 10.1016/j.molcel.2025.11.009. Epub 2025 Dec 3.