Recent Publications

BRD2 bridges TFIID and MOF-H4K16ac-containing nucleosomes to promote transcriptional initiation.
Zheng B, Qiu R, Gold S, Iwanaszko M, Aoi Y, Howard BC, Das M, Shilatifard A.
Mol Cell. 2025 Dec 31:S1097-2765(25)00984-0. doi: 10.1016/j.molcel.2025.12.010. Online ahead of print.
Development of a SIN1 targeting inhibitor as a novel therapeutic approach for the treatment of malignancies.
Beauchamp EM, et al. Among authors: goo ya, platanias lc.
Mol Cancer Ther. 2025 Dec 22. doi: 10.1158/1535-7163.MCT-25-0298. Online ahead of print.
Intact Mass Profiling Reveals Phospho-Proteoforms of the Catenins (85-110 kDa) Regulated by Actomyosin Contractility.
Huang CF, Su T, Flozak AS, Gottardi CJ, Kelleher NL.
Angew Chem Int Ed Engl. 2025 Dec 22;64(52):e18593. doi: 10.1002/anie.202518593. Epub 2025 Oct 29.
Defective RNA processing and ELOA-mediated transcriptional elongation in reversible cellular senescence suggest aging by transcription.
Parast S, Wang S, Iwanaszko M, He Y, Olgun DG, Gold S, Zeidner JM, Aoi Y, Howard BC, Thakur WR, Ramani V, Shilatifard A.
Mol Cell. 2025 Dec 18;85(24):4545-4561.e8. doi: 10.1016/j.molcel.2025.11.021.
SPAP: Soluble Human Plasma Proteoform Analysis via Acetonitrile Precipitation and Top-Down Mass Spectrometry.
Sanchez A, et al. Among authors: kelleher nl.
J Am Soc Mass Spectrom. 2025 Dec 18. doi: 10.1021/jasms.5c00289. Online ahead of print.
Rate-limiting enzymes in nucleotide metabolism synchronize nucleotide biosynthesis and chromatin formation.
Srivastava S, Samaniego-Castruita D, Srivastava S, Khurana S, Rehman J, Shukla V, Ben-Sahra I, Foltz DR.
Mol Cell. 2025 Dec 18;85(24):4510-4525.e8. doi: 10.1016/j.molcel.2025.11.009. Epub 2025 Dec 3.
Heat-shock pathway activation by TRC051384 protects spiral ganglion neurons from noise-induced hearing loss.
Yu J, Ramirez MA, Wang YZ, Edassery S, Shramuk M, Cheatham MA, Rutherford MA, Welty LJ, Savas JN.
bioRxiv [Preprint]. 2025 Dec 11:2025.12.08.693048. doi: 10.64898/2025.12.08.693048.
Automated Enzymatic Deglycosylation of Monoclonal Antibody with the SampleStream Platform.
Fisher TD, Compton PD, Robey MT, Fellers RT, Durbin KR, Kelleher NL.
J Am Soc Mass Spectrom. 2025 Dec 8. doi: 10.1021/jasms.5c00242. Online ahead of print.
Targeting p300 and CBP abolishes HOXB13-loss-induced lipogenesis and tumor metastasis.
Lu X, Peng L, Chu Q, Ye S, Liu M, Hussain M, Bilen MA, Harik LR, Melamed J, Zhao JC, Yu J.
JCI Insight. 2025 Nov 24;10(22):e195743. doi: 10.1172/jci.insight.195743. eCollection 2025 Nov 24.
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle.
Nengroo MA, et al. Among authors: ben sahra i, mendillo ml.
Mol Cell. 2025 Nov 20;85(22):4215-4228.e9. doi: 10.1016/j.molcel.2025.10.002. Epub 2025 Oct 28.