News and Announcements
Read the latest news from Northwestern University Feinberg School of Medicine’s Department of Biochemistry and Molecular Genetics. The links below take you to articles where you can learn more about our faculty’s latest achievements, awards and honors.
Northwestern scientists recently identified a new protein complex that is upregulated in acute myeloid leukemia, potentially explaining why current therapies are often ineffective.
A new study has uncovered a key mechanism underlying the control of a co-factor that is essential for all cells to grow and divide, and which may also play a key role in cancer cell growth.
A Northwestern Medicine study provides new insights into a signaling pathway in metastatic prostate cancer and suggests that a novel drug combination may improve treatment response and slow cancer growth.
Northwestern Medicine scientists have demonstrated that a specific mitochondrial protein complex is essential to the immunosuppressive activity of regulatory T-cells.
Northwestern Medicine scientists have discovered two successful therapies that slowed the progression of pediatric leukemia in mice, the first step towards a pediatric leukemia “super drug.”
Northwestern Medicine scientists have discovered that an enzyme called EZH2 can activate expression of the androgen receptor gene, which drives prostate cancer growth.
Inhibiting CHAF1B, a protein that normally helps replenish blood cells, may be a promising treatment for leukemia, according to a recent study.
A Northwestern Medicine study has revealed new insights into a pathway in prostate cancer and identified a potential new therapeutic target for aggressive disease.
A recent study found that stability of chromatin structures across DNA replication requires cooperation between a histone chaperone and DNA replication machinery; a mechanism of epigenetic inheritance.
Leon Platanias steers the Lurie Cancer Center toward better patient outcomes. Read the story in Northwestern Medicine magazine.
Armed with a prestigious new grant, investigators prepare to rapidly translate scientific breakthroughs into better brain tumor therapies. Read the story in Northwestern Medicine magazine.
The Simpson Querrey Center for Epigenetics is connecting the Northwestern academic and medical community to integrate the study of epigenetics into science and clinical care.
Inflammation has unexpected effects on body clock function and can lead to sleep and shiftwork-type disorders, according to a new study.
A kill code is embedded in every cell in the body whose function may be to cause the self-destruction of cells that become cancerous, reports a new Northwestern Medicine study.
Targeting cancer cells with a transcription elongation inhibitor delayed tumor progression in animal models, according to a recent Northwestern Medicine study.
Arthur Prindle, PhD, assistant professor of Biochemistry and Molecular Genetics, will study bacterial communication and its potential applications to human health with a five-year grant from The David and Lucile Packard Foundation.
Scientists have developed soft materials that assemble and disassemble on demand, opening the door for applications including robotics, drug delivery and tissue regeneration.
The three-dimensional atomic structure of the epigenetic driver COMPASS was solved for the first time in a study published in the journal Cell.
Ali Shilatifard, PhD, has been appointed editor of Science Advances, an open-access journal published by the American Association for the Advancement of Science, which also publishes the journal Science.
Northwestern Medicine scientists have discovered an epigenetic imbalance that can lead to cancer, and used these findings to inhibit tumors in models.
Scientists are one step closer to a stem cell treatment for muscular dystrophy after Northwestern Medicine investigators demonstrated improvements in muscle tissue differentiation in stem cells.
Northwestern Medicine scientists have uncovered new findings about a protein called SET1B, which could offer a novel approach to treating triple-negative breast cancer.
Northwestern Medicine scientists have discovered that a protein called BRWD2/PHIP binds to H3K4 methylation, a key molecular event that influences gene expression.
A newly discovered gene mutation may increase a patient’s risk of genetic heart disease, presenting a target for therapy or genetic screening down the road.
Two Northwestern Medicine scientists have received NIH Director’s Awards, which fund innovative research with high-impact potential.
Northwestern Medicine scientists have discovered surprising findings about an enzyme central to gene expression and mutated in many cancers.
A Northwestern Medicine study found a novel chemical transformation in the formation of colibactin, a toxic agent produced by gut bacteria, including certain strains of E. Coli.
A new Northwestern Medicine study reveals surprising findings about an enzyme called Set1A and its function in embryonic stem cell self-renewal and differentiation.
The major features of Parkinson’s disease have been linked to a toxic cascade beginning with oxidized dopamine, providing a possible therapeutic pathway.
Northwestern scientists have found that nutritional, microbial and psychosocial exposures early in infant development predict DNA methylation later in life.