News and Announcements
Read the latest news from Northwestern University Feinberg School of Medicine’s Department of Biochemistry and Molecular Genetics. The links below take you to articles where you can learn more about our faculty’s latest achievements, awards and honors.
Inhibiting CHAF1B, a protein that normally helps replenish blood cells, may be a promising treatment for leukemia, according to a recent study.
A Northwestern Medicine study has revealed new insights into a pathway in prostate cancer and identified a potential new therapeutic target for aggressive disease.
A recent study found that stability of chromatin structures across DNA replication requires cooperation between a histone chaperone and DNA replication machinery; a mechanism of epigenetic inheritance.
Leon Platanias steers the Lurie Cancer Center toward better patient outcomes. Read the story in Northwestern Medicine magazine.
Armed with a prestigious new grant, investigators prepare to rapidly translate scientific breakthroughs into better brain tumor therapies. Read the story in Northwestern Medicine magazine.
The Simpson Querrey Center for Epigenetics is connecting the Northwestern academic and medical community to integrate the study of epigenetics into science and clinical care.
Inflammation has unexpected effects on body clock function and can lead to sleep and shiftwork-type disorders, according to a new study.
A kill code is embedded in every cell in the body whose function may be to cause the self-destruction of cells that become cancerous, reports a new Northwestern Medicine study.
Targeting cancer cells with a transcription elongation inhibitor delayed tumor progression in animal models, according to a recent Northwestern Medicine study.
Arthur Prindle, PhD, assistant professor of Biochemistry and Molecular Genetics, will study bacterial communication and its potential applications to human health with a five-year grant from The David and Lucile Packard Foundation.
Scientists have developed soft materials that assemble and disassemble on demand, opening the door for applications including robotics, drug delivery and tissue regeneration.
The three-dimensional atomic structure of the epigenetic driver COMPASS was solved for the first time in a study published in the journal Cell.
Ali Shilatifard, PhD, has been appointed editor of Science Advances, an open-access journal published by the American Association for the Advancement of Science, which also publishes the journal Science.
Northwestern Medicine scientists have discovered an epigenetic imbalance that can lead to cancer, and used these findings to inhibit tumors in models.
Scientists are one step closer to a stem cell treatment for muscular dystrophy after Northwestern Medicine investigators demonstrated improvements in muscle tissue differentiation in stem cells.
Northwestern Medicine scientists have uncovered new findings about a protein called SET1B, which could offer a novel approach to treating triple-negative breast cancer.
Northwestern Medicine scientists have discovered that a protein called BRWD2/PHIP binds to H3K4 methylation, a key molecular event that influences gene expression.
A newly discovered gene mutation may increase a patient’s risk of genetic heart disease, presenting a target for therapy or genetic screening down the road.
Two Northwestern Medicine scientists have received NIH Director’s Awards, which fund innovative research with high-impact potential.
Northwestern Medicine scientists have discovered surprising findings about an enzyme central to gene expression and mutated in many cancers.
A Northwestern Medicine study found a novel chemical transformation in the formation of colibactin, a toxic agent produced by gut bacteria, including certain strains of E. Coli.
A new Northwestern Medicine study reveals surprising findings about an enzyme called Set1A and its function in embryonic stem cell self-renewal and differentiation.
The major features of Parkinson’s disease have been linked to a toxic cascade beginning with oxidized dopamine, providing a possible therapeutic pathway.
Northwestern scientists have found that nutritional, microbial and psychosocial exposures early in infant development predict DNA methylation later in life.
A synthetic material developed at Northwestern Medicine could direct a patient’s existing cells to transform into stem cells, creating a new treatment path for stem cell therapy.
The first drug using spherical nucleic acids to be systemically given to humans has been developed by Northwestern University scientists and approved by the Food and Drug Administration as an investigational new drug for an early-stage clinical trial in the deadly brain cancer glioblastoma multiforme.
A new Northwestern Medicine study, published in Genes and Development, has identified two DNA elements crucial to the activation of a set of genes that drive the early development of embryos.
Northwestern Medicine scientists have demonstrated an important role for the methylation of the amino terminus of a specific protein in maintaining centromere function and chromosome segregation, both important in cell division.
Northwestern Medicine scientists and collaborators have shown that a protein thought to form calcium ion channels instead regulates the activity of another member of the family to modulate immune responses.
A paper published in Molecular Cell provides new insight into a protein complex called COMPASS and its function during histone methylation, a key modification that regulates gene expression.